Analytical chemistry Books
NY Research Press Analytical Chemistry: Tools, Techniques and Applications
£104.62
NY Research Press Analytical Chemistry: Quantitative and Qualitative Analysis
£95.71
NY Research Press Bioanalytical Chemistry
£102.60
Murphy & Moore Publishing Recent Advances in Analytical Chemistry
Book Synopsis
£112.23
Bod Third Party Titles Advances in Analytical and Coordination Chemistry Applications and Innovations
£107.10
£101.15
IntechOpen Raman Spectroscopy
£107.10
Green Hill Publishing Compendium Synthetica
£39.94
Springer The Art and Science of Coffee Fermentation
Book SynopsisIntroduction.- Coffee flavor development.- Basics of fermentation.- The main actors.- Coffee processing.- Let’s put it all together.- Sustainability & wastewater.- Some last words.
£26.59
Springer All About Hops The Crop its Cultivation and its Uses in Brewing and Beyond
Book SynopsisA spotlight on the economic and statistical data of the international and Italian hop sector.- Hop Botany and Physiology.- The evolution of hop breeding: Integrating molecular markers and genomic insights.- Hops cultivation and production.- Hop Diseases: Characteristics and Management.- Entomology of Hops (Pests).- Post-harvest Hop Waste Management.- Spent Hops: Utilisation, Impact, and Future Prospects.- Hop chemistry and biochemistry.- Sustainable hop extracts for food and non-food applications.- Humulus lupulus L.: pharmacological properties and medicinal use.
£151.99
Springer International Publishing AG Chemometrics in Food Control Based on Elemental Analysis
Book SynopsisCHAPTER 1. Key Issues Constituting the Book Content.- CHAPTER 2. Meat and its Products.- CHAPTER 3. Fish Flesh.- CHAPTER 4.Seafood (Molluscs and Crustaceans).- CHAPTER 5. Milk and Dairy Products.- CHAPTER 6. Honey and its Products.- CHAPTER 7. Cereal and its Products.- CHAPTER 8. Olive Oils and Oilseeds.- CHAPTER 9. Vegetables, Legume Seeds and Spices.- CHAPTER 10. Mushrooms.- CHAPTER 11. Fruits and their Products.- CHAPTER 12. Tea and its Infusion.- CHAPTER 13. Coffee and its Infusion.- CHAPTER 14. Cocoa, Sugar and their Products.- CHAPTER 15. Mineral and Drinking Water.- CHAPTER 16. Wine and other Alcoholic Beverages.
£142.49
Springer Foundation Models for General Medical AI
Book SynopsisLamps: Learning Anatomy from Multiple Perspectives via Self-supervision.- Segment Anything for Cell Tracking.- BioVFM-21M: Benchmarking and Scaling Self-Supervised Vision Foundation Models for Biomedical Image Analysis.- From Pathology to Radiology: Evaluating the Applicability of Pathology Foundation Models.- Pathology Foundation Models are Scanner Sensitive: Benchmark and Mitigation with Contrastive ScanGen Loss.- Improved Training Sample Efficiency and Inter-Device Generalizability in Optical Coherence Tomography Fluid Segmentation via Foundation Models.- Taming Stable Diffusion for Computed Tomography Blind Super-Resolution.- RadiSimCLIP: A Radiology Vision-Language Model Pretrained on Simulated Radiologist Learning Dataset for Zero-Shot Medical Image Understanding.- Improving Medical Visual Instruction Tuning with Labeled Datasets.- DR.SIMON: Domain-wise Rewrite for Segment-Informed MedicalOversight Network.- The Data Behind the Model: Gaps and Opportunities for Foundation Models in Brain Imaging.- LGE Scar Quantification Using Foundation Models for Cardiac Disease Classification.- Beyond Broad Applications: Can Pathology Foundation Models Adapt to Hematopathology.- EndoTracker: Robustly Tracking Any Point in Endoscopic Surgical Scene.- Temporally-Constrained Video Reasoning Segmentation and Automated Benchmark Construction.- Cross-Modal Knowledge Distillation for Chest Radiographic Diagnosis via Embedding Expansion, Reconstruction, and Classification.- Random Direct Preference Optimization for Radiography Report Generation.- Test Time Adaptation of Medical Vision-Language Models.- MaskedCLIP: Bridging the Masked and CLIP Space for Semi-Supervised Medical Vision-Language Pre-training.
£44.99
De Gruyter Qualitative Schnellanalyse der Kationen und
Book Synopsis
£95.00
De Gruyter Nanostructured Materials: Applications, Synthesis
Book SynopsisFrom a political, societal and scientific point of view, it is imperative to counteract global warming and overcome energy scarcity. From a scientific perspective, nanostructured materials play a crucial role in achieving these goals, e.g. in the development of energy-saving light-emitting diodes, solar cells, rechargeable batteries or gas storage technologies. However, the potential design of the structure-related properties of such nanostructured compounds requires in-depth knowledge and strict control of their crystallization processes, which can be achieved by monitoring the corresponding chemical reactions in situ. This book is aimed at undergraduate and graduate students who wish to gain an overview of the applications, synthesis, or in situ characterization of inorganic nanostructured compounds such as lanthanide-based materials, quantum dots, magnetic nanoparticles, bioceramics, battery electrodes, and metal-organic frameworks.Table of ContentsFrom the Contents: - Nanoparticles - Metal-Organic Frameworks (MOFs) - Luminescent Materials - Light-Emitting Diodes (LEDs) - Lanthanides - In-situ Characterization
£127.78
De Gruyter Thermal Analysis and Calorimetry: Versatile
Book SynopsisThis book summarizes the application of thermal analysis tools in different research areas. Areas covered include characterization of catalytic materials, plastics and polymers, analysis of salts, minerals and oxides. The reader is provided with an overview of experimental strategy, methodology, usage of complementary thermoanalytical methods and the type of information which could be drawn depending on the research field.
£77.90
De Gruyter Instrumental Analysis: Chemical IT
Book SynopsisThis book introduces the techniques of Instrumental Analysis with respect to fundamental basics, technical realization, key applications, major strengths, and limitations. The approach used is to highlight differences and consolidate similarities of the techniques, focusing especially on the viewpoint of the laboratory rather than on the scientific ideal or the limits of what is possible.
£75.05
De Gruyter Flow Chemistry – Fundamentals
Book SynopsisThe fully up-dated edition of the two-volume work covers both the theoretical foundation as well as the practical aspects. Presenting the complete insight into driving a chemical reaction provides a deep understanding for new potential technologies. Updated overview on devices and new key concepts of experimental procedures. Vol. 2: Applications.
£65.55
De Gruyter Flow Chemistry – Applications
Book SynopsisThe fully up-dated edition of the two-volume work covers both the theoretical foundation as well as the practical aspects. A strong insight in driving a chemical reaction is crucial for a deeper understanding of new potential technologies. New procedures for warranty of safety and green principles are discussed. Vol. 1: Fundamentals.
£65.55
De Gruyter Forensic Chemistry: Fundamentals
Book Synopsis FORENSIC CHEMISTRY FUNDAMENTALS strives to help scientists & lawyers,& students, understand how their two disciplines come together for forensic science,in the contexts of analytical chemistry & related science more generally, and thecommon law systems of Canada, USA, UK, the Commonwealth.In this book, forensics is considered more generally than as only for criminallaw; workplace health & safety, and other areas are included. And, two issues ofCanadian legal process are argued as essays in the fi nal two chapters.
£65.55
£44.55
De Gruyter Introduction
Book SynopsisNuclear chemistry represents a vital fi eld of basic and applied research. This Volume 1 Nuclear- and Radiochemistry: Introduction describes the relevant parameters of stable and unstable atomic nuclei, the various modes of radioactive transformations, the corresponding types of radiation, and fi nally the mechanisms of nuclear reactions. The 2nd edition has updated the chapters throughout with additional material. The reader is also referred to the new edition of Volume 2 Nuclear- and Radiochemistry: Modern Applications.
£89.30
De Gruyter Hydrochemistry: Basic Concepts and Exercises
Book SynopsisThis textbook introduces the elementary basics of hydrochemistry with special focus on reaction equilibria in aquatic systems and their mathematical description. Topics discussed in this textbook include: structure and properties of water, concentration measures and activities, colligative properties, basics of chemical equilibria, gas-water partitioning, acid/base reactions, precipitation/dissolution, calco-carbonic equilibrium, redox reactions, complex formation, and sorption. Examples within the text as well as problems to be solved by the reader support the acquisition of knowledge. Complete and detailed solutions to the problems are given in a separate chapter.
£56.52
De Gruyter Analytical Methods in Chemical Analysis: An Introduction
Book SynopsisAnalytical Chemistry is important and applied, experimental field of science that employs different instruments, and methods for the collection, separation, identification, and quantification of various organic, inorganic, and biological molecules. This interdisciplinary branch is based not only on chemistry but also on other disciplines such as biology, physics, pharmaceutical, and many areas of technology. The book is organized into six sections and provides information pertinent to the important techniques, and methods employed in analytical chemistry. It covers the basic concepts of qualitative and quantitative analysis, spectrochemical methods of analysis, along with thermal- and electroanalytical methods. Qualitative analysis identifies analytes, while quantitative analysis determines the concentration or numerical amount of the molecules under study. This book also exposes students to the different laws of spectroscopy, and various electronic transitions that occur in the different regions of the electromagnetic spectra. The main objective of this work is to develop an understanding and make learners familiar with the basic analytical methods employed in the chemical analysis of various compounds.
£63.65
Wiley-VCH Verlag GmbH The Troubleshooting and Maintenance Guide for Gas Chromatographers
Book SynopsisThis fourth edition of the classic guide for every user of gas chromatographic instrumentation is now updated to include such new topics as fast GC using narrow, short columns, electronic pressure control, and basic aspects of quantitative gas chromatography. The author shares his many years of experience in technical support for gas chromatography users, addressing the most common problems, questions and misconceptions in capillary gas chromatography. He structures and presents the material in a concise and practical manner, suitable even for the most inexperienced user without any detailed knowledge of chemistry or chromatography. For lab technicians in chemistry, analytical, food, medicinal and environmental chemists, pharmaceutists.Trade Review"This book is valuable basic GC guideline especially for lab technicians in food, medicinal and environmental chemistry, but also for pharmaceutics." (Advanced in Food Sciences, January 2008) Reviews of the Previous Edition: Dean Rood has compiled all the relevant information needed to help in the troubleshooting and maintenance of any GC, you find yourself with all the necessary support no matter where you are, this book will guide you through the process of fault finding and fixing and you will be able to go back on business without the fuss of following instructions over the phone or waiting for the service to come over, I think it is fantastic! (amazon.com customer review)"Das Buch ist gut lesbar und leicht verständlich geschrieben. Es gibt dem Praktiker wichtige Hinweise?." Gefahrstoffe Reinhaltung der Luft April 2008Table of ContentsIntroduction to Capillary Gas Chromatography Basic but Essential Definitions and Equations Capillary GC Columns: Tubing Capillary GC Columns: Stationary Phases Capillary GC Columns: Dimensions Carrier Gas Operation and Maintenance of Injectors Operation and Maintenance of Detectors Column Installation Column Test Mixtures Causes and Prevention of Column Damage Troubleshooting Capillary GC Systems
£128.66
Wiley-VCH Verlag GmbH Validierung in der Analytik
Book SynopsisDer Praxisleitfaden zur manchmal ungeliebten aber notwendigen Validierung analytischer Methoden bietet auf weniger als 300 Seiten alles, was man wissen muss: Teil A beschreibt die theoretischen und konzeptionellen Grundlagen. Teil B erklärt die ISO-konforme Durchführung einer Validierung samt einer Diskussion der häufigsten Fehlerquellen. Ein umfangreicher Anhang enthält Zusatzinformationen, Übersichten und ein Glossar der wichtigsten Fachbegriffe. Nützliche Hilfen wie Rechenbeispiele, Praxistipps, Beschreibung häufiger Fehler sowie Checklisten sind durchgehend zu finden und erleichtern das Arbeiten mit dem Buch. Unverzichtbares Grundwissen für jeden Analytiker, der ein Analysenverfahren validieren muss. Aus Rezensionen der Vorauflage: "Besonders lehrreich für den Anfänger ist die Vielzahl von praktischen Beispielen" (Die Nahrung) "Bravo, endlich ist er da, der lang ersehnte Brückenschlag von einer überwiegend statistisch-mathematischen und damit nicht immer ganz praxisnahen Betrachtung des Themas hin zu zweckdienlichen und damit auch in der täglichen Routine eines analytischen Laboratoriums gut beschreitbaren Ansätzen!" (Deutsche Lebensmittel-Rundschau)Table of Contentsvorwort Zur Zweiten Auflage v Vorwort Zur Ersten Auflage vi 1 Grundsätze der Validierung in der Analytik und im Prüfwesen 1 Stavros Kromidas und Janusz S. Morkowski 1.1 Einführung 1 1.2 Definition, Erläuterung und Kommentierung von Begriffen der Qualitätssicherung 3 1.2.1 Validierung 4 1.2.2 Verifizierung 11 1.2.3 Qualifizierung bzw. Qualifikation 11 1.2.4 Charakterisierung 13 1.2.5 Messen, Prüfen, Justieren, Kalibrieren, Eichen 14 1.3 Grundvoraussetzungen für die Validierung einer analytischen Methode 15 1.4 Die Unsicherheit der Ergebnisse von Messungen, Prüfungen und Analysen 16 1.5 Methoden zur Charakterisierung von analytischen Methoden 18 1.5.1 Die Charakterisierungsmethoden 19 1.5.1.1 Erste Charakterisierungsmethode: systematische Beurteilung der Faktoren, die das analytische Ergebnis beeinflussen können 20 1.5.1.2 Zweite Charakterisierungsmethode: Kalibrierung mit Referenznormalen/Referenzmaterialien und gleichzeitige Untersuchung der Einflussgrößen 20 1.5.1.3 Dritte Charakterisierungsmethode: Vergleich der Ergebnisse, die mit einem weiteren Verfahren ermittelt wurden 21 1.5.1.4 Vierte Charakterisierungsmethode: Vergleichsmessungen zwischen Laboratorien (Laborvergleichsversuche, Ringversuche) 23 1.5.1.5 Fünfte Charakterisierungsmethode: Geordnete Schätzung der Ergebnisunsicherheit auf der Grundlage von Wissen und Erfahrung (Ein Schätzverfahren vom Typ B) 24 1.5.1.6 Kombination der fünf Charakterisierungsmethoden 28 1.5.1.7 Weitere Methoden vom Typ B 28 1.6 Charakterisierung (Qualifizierung) von Methoden als letzter Schritt einer Validierungsprozedur 29 1.7 Freigabe von Methoden, Dokumentation 30 1.8 Schlussbemerkungen 30 2 Vor Beginn der Validierungsarbeiten: Voraussetzungen, Dokumentation, Gerätequalifizierung 33 Stavros Kromidas 2.1 Voraussetzungen 33 2.2 Dokumentation 34 2.3 Gerätequalifizierung 36 2.3.1 Das „V“-Modell 39 2.3.2 Empfehlungen für die Praxis 41 3 Die Validierungsparameter einer analytischen Methode 43 Stavros Kromidas 4 Präzision 47 Stavros Kromidas 4.1 Definitionen und Erläuterungen 47 4.2 Präzisionsarten 50 4.2.1 Wiederholpräzision, Wiederholbarkeit (früher: Wiederholgenauigkeit) 50 4.2.2 Vergleichspräzision, Vergleichbarkeit (häufig auch: Reproduzierbarkeit, selten Übertragbarkeit) 50 4.2.3 Laborpräzision oder laborinterne Vergleichspräzision 50 4.2.4 Weitere Präzisionen 50 4.3 Mess- und Methodenpräzision 52 4.4 Rechenbeispiele 52 4.4.1 Vergleich von Mittelwerten und Variationskoeffizienten 52 4.4.2 Vergleich von Messwertreihen 54 4.4.3 Vergleich von Methoden, die aus stochastisch unabhängigen Schritten bestehen 56 4.5 Angaben zur Präzision und deren Deutungsmöglichkeiten 58 4.6 Umgang mit Zahlen und Möglichkeiten zu deren Beurteilung 60 4.6.1 Ausreißertests oder Verlässlichkeitstests 61 4.6.1.1 Dixon-Test 61 4.6.1.2 Grubbs-Test 63 4.6.1.3 Henning-Test 64 4.6.1.4 Mittelwertabweichung 64 4.6.2 Trendtest nach Neumann 64 4.6.3 Ermittlung der Wiederholgrenze 65 4.6.4 F- und Cochran-Test 66 4.6.4.1 F-Test, Test auf Varianzenhomogenität 66 4.6.4.2 Cochran-Test 67 4.6.5 Zusammenfassung der Tests und abschließendes Beispiel 68 4.7 Abschließende Fragen zur Präzision 71 4.7.1 Welche Präzision kann noch akzeptiert werden? 71 4.7.1.1 Messpräzision 72 4.7.1.2 Methodenpräzision 72 4.7.2 Wie kann ich die Präzision erhöhen? 74 4.7.2.1 Was sind die Vor- und Nachteile bei großer Präzision? 75 5 Richtigkeit 77 Stavros Kromidas 5.1 Definitionen und Erläuterungen 77 5.2 Prüfung auf Richtigkeit 78 5.2.1 Vergleich mit einem (oder mehreren) Referenz- oder Arbeitsstandard(s) 78 5.2.1.1 Vergleich einer Probe unbekannten Gehaltes mit einem Standard bekannten Gehaltes auf Richtigkeit 78 5.2.1.2 Vergleich mehrerer Proben (oft 6) unterschiedlichen Gehaltes, die idealerweise den erwarteten Arbeitsbereich abdecken, mit Referenzstandardproben bekannten Gehaltes 82 5.2.2 Vergleich mit einer unabhängigen, möglichst validierten Methode bekannter Richtigkeit 84 5.2.3 Wiederfindungsexperimente nach Zusatz bekannter Menge an Analyt (Referenzsubstanz!) 86 5.2.4 Elementbilanzierung 87 5.2.5 Indirekte Überprüfung über Massenbilanzen 87 5.2.6 Plausibilitätsbetrachtung 88 5.3 Messunsicherheit, Ergebnisunsicherheit und Vertrauensbereich 88 5.4 Zusammenfassung von Tests zum Vergleich und zur Beurteilung von Zahlen und Zahlenreihen 98 5.5 Wie soll ich nun die Richtigkeit überprüfen? 99 5.5.1 Einfacher Test zum Vergleich zweier Messwertreihen 101 6 Robustheit 103 Stavros Kromidas 6.1 Definition und Erläuterungen 103 6.2 Prüfung auf Robustheit 104 6.2.1 Methodenrobustheit, Robustheit I: frühes Stadium 105 6.2.2 Verfahrensstabilität 105 6.2.2.1 Stabilität von Lösungen 105 6.2.3 Anwendbarkeit, Robustheit II 107 6.3 Zeitlicher Ablauf der Robustheitstests 109 6.4 Kommentare, Hinweise 111 6.5 Robustheit in der HPLC 111 6.5.1 Vorgehen zur Überprüfung der Robustheit in der HPLC 115 7 Selektivität und Spezifität 119 Stavros Kromidas 7.1 Definitionen und Erläuterungen 119 7.2 Grundsätzliches zur Prüfung auf Selektivität 120 7.3 Prüfung auf Selektivität von bekannten Proben in der HPLC 121 7.4 Prüfung auf Selektivität in der HPLC bei Proben unbekannter Zusammensetzung 121 7.4.1 Systematische Variation der Methodenparameter 121 7.5 Überprüfung der Selektivität in der HPLC – Schnellmethoden 129 7.5.1 Peakbreite und Retentionszeit 129 7.5.2 Asymmetriefaktor und Peakhöhe 130 7.5.3 Asymmetriefaktor und Retentionszeit 132 7.5.4 Ableitungschromatographie 133 7.6 Zusammenfassung 134 8 Linearität 137 Stavros Kromidas 8.1 Einleitung und Definitionen 137 8.1.1 Wozu braucht man eigentlich eine Kalibrierung? 137 8.1.2 Über Linearität und „Mathematik“ 137 8.2 Durchführung der Linearitätstests 139 8.2.1 Grundsätzliches 139 8.2.1.1 Konzentrationsbereich für den Linearitätstest 141 8.2.1.2 Arbeitsbereich der Kalibriergeraden 141 8.2.2 Prüfung auf Linearität 142 8.2.3 Beurteilung der Ergebnisse 147 8.2.3.1 Wann ist nun das Prognoseintervall klein? 148 8.2.4 Welche Methodenkenndaten/Informationen können aus einer linearen Kalibrierfunktion gewonnen werden? 151 8.2.4.1 Arbeitsbereich 151 8.2.4.2 Reststandardabweichung 154 8.2.4.3 Verfahrensvariationskoeffizient 156 8.2.5 Fließschema zur Kalibrierung und zur Ermittlung der Linearität 163 8.2.6 Beispiel zur Prüfung auf Linearität [40] 168 8.2.6.1 Prüfung auf Varianzenhomogenität 168 8.2.6.2 Ermittlung der Kalibrierfunktion 170 8.2.6.3 Kalibrierstrategien 175 8.2.6.4 Ermittlung der unbekannten Konzentration 177 8.2.6.5 Ausreißertest nach Huber 177 8.2.6.6 Ergebnis der Bestimmung 177 8.2.7 Eine kritische Betrachtung der Kriterien für Linearität 179 8.2.8 Gewichtete Lineare Regression 183 8.2.8.1 Anwendung 184 8.2.8.2 Varianzquotientenwichtung 184 8.2.8.3 Praxis 185 9 Wiederfindung oder Wiederfindungsrate 189 Stavros Kromidas 9.1 Definitionen und Erläuterungen 189 9.2 Ermittlung der Wiederfindungsrate 189 9.2.1 Analyse von zertifizierten Referenzmaterialien 189 9.2.2 Zudosierungs- oder Aufstockungsexperimente („spiken“ einer Probe) 190 9.2.3 Indirekt über die Richtigkeit 191 9.2.4 Massenbilanzierung 191 9.3 Praktische Hinweise und Bemerkungen 191 10 Nachweis-, Bestimmungs- und Erfassungsgrenze 193 Stavros Kromidas 10.1 Definitionen und Erläuterungen 193 10.2 Ermittlung der Nachweis-, Bestimmungs- und Erfassungsgrenze 195 10.3 Kommentare und Hinweise 197 10.3.1 Leerwert- und Kalibriermethode 197 10.3.2 Peak/Rausch-Verhältnis 197 10.4 Abschlussbemerkungen und Empfehlungen 198 11 Arbeitsbereich 201 Stavros Kromidas 11.1 Prozess- und Methodenfähigkeit 202 11.1.1 Definitionen und Erläuterungen 202 11.2 Beispiele 203 11.3 Akzeptanzkriterien, Bewertung von Prozessen und Methoden 206 11.4 Maßnahmen bei unzureichender Methodenfähigkeit – zu kleine c MK ’s 211 12 Häufige Fragen zur Validierung 213 Stavros Kromidas 12.1 Ermittlung der interessantesten Fragen 213 12.2 Antworten auf die sieben wichtigsten Fragenkomplexe 214 12.2.1 „Was ist der Mindestumfang einer Validierung?“ 214 12.2.2 „Was ist eigentlich Präzision …?“ 217 12.2.3 Die Zeitknappheit 223 12.2.4 Behördliche/rechtliche Anforderungen 223 12.2.5 Hilfen, Infos 225 12.2.6 Validierungsumfang als Funktion von Methode, Ziel 227 12.2.7 Sonstiges 228 12.3 Häufige Fehler bei der Validierung analytischer Methoden 229 12.3.1 Allgemeine Fehler und Interpretationsfehler 229 12.3.2 Fehler im Zusammenhang mit der praktischen Durchführung der Validierung 236 12.3.2.1 Präzision 236 12.3.2.2 Richtigkeit 237 12.3.2.3 Robustheit 238 12.3.2.4 Systemeignungstest 238 12.3.2.5 Linearität 239 12.3.2.6 Nachweis- und Bestimmungsgrenze 240 12.3.2.7 Selektivität 240 13 Trends in der Validierung 245 Michael Haustein und Manfred Neupert 13.1 Einleitung 245 13.2 Bewertung von Validierungsdaten – statistische Tests vs. Akzeptanzgrenzen 245 13.3 Risikomanagement in der Analytik 247 13.4 Messunsicherheit im Qualitätskontrolllabor – Abschätzung aus Validierungsdaten 250 13.4.1 Zufällige Abweichungen 251 13.4.2 Systematische Abweichungen 252 13.4.3 Kombinierte Messunsicherheit 253 13.4.4 Erweiterte Messunsicherheit 254 13.5 Computer Aided Validation (CAV) – Automatisierungstrend in der Validierung 254 A1 Abkürzungen (Auswahl) 257 A2 Standardarbeitsanweisung SOP 1–18: Validierung und Ergebnisunsicherheit von Prüfverfahren 261 Roman Klinkner A2.1 Zweck 261 A.2.2 Geltungsbereich 261 A2.3 Begriffe/Abkürzungen 261 A2.4 Befugnisse und Verantwortlichkeiten 263 A2.5 Beschreibung 263 A2.5.1 Grundprinzip der Validierung 263 A2.5.2 Validierungsplanung 264 A2.5.2.1 Festlegung der Vorgaben 264 A2.5.2.2 Festlegung des Validierungsumfangs 264 A2.5.3 Validierungsdurchführung 266 A2.5.3.1 Ergebnisunsicherheit 266 A2.5.3.2 Wiederholpräzision 267 A2.5.3.3 Vergleichspräzision 267 A2.5.3.4 Qualitätsregelkarte (Kontrollkarte) 268 A2.2.3.5 Ringversuche 268 A2.5.3.6 Arbeitsbereich 268 A2.5.3.7 Linearität 269 A2.5.3.8 Wiederfindung 269 A2.5.3.9 Nachweisgrenze 270 A2.5.3.10 Bestimmungsgrenze 270 A2.5.3.11 Verfahrenskenndaten bei Kalibrierverfahren 270 A2.5.3.12 Robustheit 270 A2.5.3.13 Spezifität 272 A2.5.4 Validierungsbericht 272 A2.6 Dokumentation 273 A2.7 Hinweise und Anmerkungen 273 A2.7.1 Mitgeltende Unterlagen 273 A2.7.2 Anmerkungen 273 A2.8 Anlagen 273 A3 Definitionen und Erläuterungen von Begriffen aus den Bereichen „Validierung“ und „Qualitätssicherung“ 275 A4 Englische Übersetzung einiger wichtiger Begriffe zum Komplex „Validierung“ (Auswahl) 317 A5 Register der Rechenbeispiele 319 A6 Statistische Tabellen 321 A7 Literatur 331 A8 Sachregister 335
£42.75
Wiley-VCH Verlag GmbH Direct Analysis in Real Time Mass Spectrometry: Principles and Practices of DART-MS
Book SynopsisClear, comprehensive, and state of the art, the groundbreaking book on the emerging technology of direct analysis in real time mass spectrometry Written by a noted expert in the field, Direct Analysis in Real Time Mass Spectrometry offers a review of the background and the most recent developments in DART-MS. Invented in 2005, DART-MS offers a wide range of applications for solving numerous analytical problems in various environments, including food science, forensics, and clinical analysis. The text presents an introduction to the history of the technology and includes information on the theoretical background, for exampleon the ionization mechanism. Chapters on sampling and coupling to different types of mass spectrometers are followed by a comprehensive discussion of a broad range of applications. Unlike most other ionization methods, DART does not require laborious sample preparation, as ionization takes place directly on the sample surface. This makes the technique especially attractive for applications in forensics and food science. Comprehensive in scope, this vital text: -Sets the standard on an important and emerging ionization technique -Thoroughly discusses all the relevant aspects from instrumentation to applications -Helps in solving numerous analytical problems in various applications, for example food science, forensics, environmental and clinical analysis -Covers mechanisms, coupling to mass spectrometers, and includes information on challenges and disadvantages of the technique Academics, analytical chemists, pharmaceutical chemists, clinical chemists, forensic scientists, and others will find this illuminating text a must-have resource for understanding the most recent developments in the field.Table of ContentsPreface xv About the Editor xvii 1 Introduction of Mass Spectrometry and Ambient Ionization Techniques 1Yiyang Dong, Jiahui Liu, and Tianyang Guo 1.1 Evolution of Analytical Chemistry and Its Challenges in the Twenty-First Century 1 1.2 Historical Overview of Mass Spectrometry and Its Role in Contemporary Analytical Chemistry 5 1.3 Desorption/Ionization in Mass Spectrometry 12 1.3.1 Electronic Ionization (EI) 13 1.3.2 Chemical Ionization (CI) 14 1.3.3 Fast Atom/Ion Bombardment Ionization (FAB) 15 1.3.4 Electrospray Ionization (ESI) 16 1.3.5 Matrix Assisted Laser Desorption/Ionization (MALDI) 18 1.3.6 Field Desorption (FD) or Field Ionization (FI) 19 1.3.7 Plasma Desorption (PD) (ICP, LTP, DART) 19 1.4 Ambient Ionization and Direct Analysis in Real Time 21 1.4.1 Ambient Ionization 21 1.4.2 Direct Analysis in Real Time 24 1.4.2.1 Mechanisms 24 1.4.2.2 Parameters 27 1.4.2.3 Devices 29 References 30 2 DART Mass Spectrometry: Principle and Ionization Facilities 43David Rondeau 2.1 Introduction 43 2.2 Metastable Gas Stream Formation 43 2.3 Ionization Mechanisms in Positive DART 45 2.3.1 Generation of Primary Ions by Ambient Air Ionization 46 2.3.2 Formation of the Protonated Molecules 50 2.3.3 Formation of the Ammonium Adducts 54 2.3.4 Formation of the Radical Cations and Their Fragments 55 2.3.5 Matrix Effects in DART Due to Sample Solvents 59 2.4 Ionization Mechanisms in Negative DART 65 2.4.1 Generation of Primary Ions by Ambient Air Ionization 65 2.4.2 Formation of Deprotonated Molecules 68 2.4.3 Formation of Radical Anions 69 2.4.4 Formation of Anionic Adducts 70 2.5 Some Parameters Affecting the DART Mass Spectra 71 2.5.1 Substitution of Helium by Nitrogen or Argon 71 2.5.2 The Temperature of the Gas Stream 75 2.5.3 The Internal Energy of Ions in DART-MS 76 2.6 Conclusion 78 References 78 3 Sampling and Analyte Enrichment Strategies for DART-MS 81WenMa, Xianjiang Li, and Huwei Liu 3.1 Dilution Strategy for Sticky Sample Analysis 81 3.2 Purification Strategy for Eliminating the Matrix Interference 82 3.2.1 Liquid Phase Extraction 82 3.2.2 Solid Phase Extraction (SPE) 86 3.2.3 Solid Phase Microextraction (SPME) 87 3.3 Derivatization Strategy to Decrease Polarity and Enhance Volatility 89 3.4 Conclusions 91 References 91 4 Optimization of DART andMass Spectrometric Parameters 97GuohuaWu andWushuang Li 4.1 Introduction 97 4.2 Effect ofWorking Gas Type, Gas Flow Rate, and Its Temperature 98 4.2.1 Gas Type 98 4.2.2 Gas Flow Rate 99 4.2.3 TheWorking Gas Temperature of DART Ionization Source 100 4.3 Effects of Grid Electrode Voltage and Sampling Speed 102 4.3.1 Effect of Grid Electrode Voltage 102 4.3.2 Effect of Sampling Speed 103 4.4 Effect of the SamplingMode 104 4.4.1 SamplingMethods 104 4.4.2 Position and Angle of the DART Ion Source 105 4.5 Effect of Ion Mode 106 4.6 Effect of Solvent Type and Reagents 108 4.7 Summary 109 References 109 5 Interfacing DART to Extend Analytical Capabilities 115Yiding Zhang, Shuting Xu, and Yu Bai 5.1 Introduction 115 5.2 Interfacing DART with Different Separation Techniques 116 5.2.1 Solid Samples 116 5.2.2 Gaseous Samples 118 5.2.3 Liquid Samples 119 5.2.3.1 Liquid Chromatography 119 5.2.3.2 Capillary Electrophoresis 123 5.3 Techniques of Interfacing DART with Other Analytical Techniques 125 5.3.1 Surface Plasmon Resonance 125 5.3.2 Ion Mobility Spectrometry 126 5.4 Conclusion and Perspectives 129 References 129 6 Application of DART-MS in Foods and Agro-Products Analysis 133Canping Pan and Lei Wang 6.1 Introduction 133 6.2 Applications of DART-MS in Agriculture and Food Science 134 6.2.1 DART-MS in Pesticide Residue Analysis 134 6.2.1.1 Fast Screening Purposes 134 6.2.1.2 Screening Highly Hazardous Pesticides in Agrochemical Formulations 140 6.2.1.3 QuantitativeMRM Residue Method 147 6.2.2 Veterinary Drug Residue Detection 148 6.2.3 Fast Detection of Melamine in Milk 149 6.2.4 Detection of Mycotoxins in Cereals 150 6.2.5 Food Component Rapid Analysis 151 6.2.6 Contaminations in Food Contact Materials (FCMs) 156 6.3 Conclusion 156 References 157 7 Application of DART-MS for Industrial Chemical Analysis 163Qiang Ma 7.1 Application on Household Items 163 7.1.1 Polydimethylsiloxane (PDMS) Analysis in Articles for Daily Use 163 7.1.2 Identification of Sulfides in Drywall 165 7.1.3 Phosphoric Acid Esters Screening in Aqueous Samples 168 7.2 Application on Food Packaging Safety and Quality Control 172 7.2.1 Identification of PDMS in Food Packaging Materials 172 7.2.2 Identification of Polymer Additives in Food and Food Packaging 175 7.2.3 Identification of Residue Primary Aromatic Amines (PAAs) in Food Packaging Materials 176 7.3 Application on Pharmaceutical Products 177 7.3.1 Toxic Glycols Identification 177 7.3.2 Identification of Active Ingredients in Chinese Herbal Medicines 179 7.4 Application on Cosmetics Quality Control 182 7.4.1 Screening of Glucocorticoids Illegal Addition 182 7.5 Application on Other Industrial Chemical Fields 184 7.5.1 Ink Discrimination on Questioned Document 184 7.5.2 Ionic Liquids Identification 189 7.6 Conclusions 190 References 190 8 Application of Direct Analysis in Real Time Coupled toMass Spectrometry (DART-MS) for the Analysis of Environmental Contaminants 193Maxime C. Bridoux and Sébastien Schramm 8.1 Introduction 193 8.2 Screening and Quantitative Analysis of Pesticides 194 8.3 Flame Retardants DART-MS Analysis 204 8.3.1 Organophosphorus Flame Retardants (OPFRs) 204 8.3.2 Brominated Flame Retardants (BFRs) 207 8.4 Use of DART-MS for the Analysis of Personal Care Products (PCPs) 210 8.4.1 Screening of Organic UV Filters inWater 210 8.4.2 Screening of Phthalic Acid Diesters 211 8.4.3 HPLC-DART-MS Analysis of Parabens 211 8.5 Use of DART-MS for the Analysis of Aerosols 212 8.5.1 Online DART for Aerosols Analysis 212 8.5.2 Offline DART Methods 213 8.5.3 Advantages and Limitations of DART-MS for Aerosols Characterization 213 8.6 Miscellaneous Environmental Application of DART-MS 214 8.7 Conclusions 215 References 216 9 Application of DART-MS in Clinical and Pharmacological Analysis 223Yue Li 9.1 Introduction 223 9.2 Sample Preparation 224 9.3 Applications of DART-MS 225 9.3.1 Rapid Determination of Small Organic Compounds in Biological Samples 225 9.3.1.1 Analysis of a Bitter Herbal Medicine Gentiana scabra Root Extract 225 9.3.1.2 Simultaneous Determination of 3-Chlorotyrosine and 3-Nitrotyrosine in Human Plasma 226 9.3.1.3 Rapid Screening for Methamphetamine, 3,4-Methylene-dioxymethamphetamine, andTheir Metabolites in Urine 227 9.3.2 Newborn Screening for Phenylketonuria 227 9.3.3 DART-MS Analysis of Skin Metabolome Changes in Ultraviolet B-Induced Mice 228 9.3.4 Application in Detection of Breast Cancer 231 9.3.5 Transmission Mode DART-MS for Fast Untargeted Metabolic Fingerprinting 232 9.3.6 Applications of Confined DART Ion Source for Online In vivo Analysis of Human Breath 233 9.3.6.1 Real-Time Analysis of Exhaled Breath 234 9.3.6.2 Real-Time Monitoring of Oral Anesthetic Drug 235 9.4 Challenges and Limitations 236 9.5 Recent Advancements 237 References 238 10 DART-MS Applications in Pharmaceuticals 241Karina G. Putri, Qianwen Wu, and Young P. Jang 10.1 Pharmaceutical Analysis 241 10.2 Quality Assurance 243 10.3 Illegal Active Pharmaceutical Ingredients and Counterfeit Drugs 244 10.4 Drug Development 247 References 251 11 Application of DART-MS in Natural Phytochemical Research 255Vikas Bajpai, Awantika Singh, Brijesh Kumar, and Kunnath P. Madhusudanan 11.1 Introduction 255 11.2 Direct Analysis in Real Time (DART)Mass Spectrometry 256 11.3 DART-MS Parameter Optimization for Phytochemical Analysis 256 11.4 Applications of DART-MS in Phytochemical Research 257 11.4.1 Qualitative Phytochemical Analysis 257 11.4.2 Cell Culture Analysis 261 11.4.3 Analysis of Volatiles 261 11.4.4 Species Identification 262 11.4.5 Metabolic Profiling and Multivariate Analysis 263 11.4.6 Quantitative Analysis 274 11.5 Hyphenated DART-MS Techniques for Phytochemical Analysis 276 11.5.1 GC and HPLC-DART-MS 276 11.5.2 TLC/HPTLC-DART-MS 276 11.5.3 Capillary Electrophoresis-DART MS 277 11.5.4 DART-IMS-MS 277 11.5.5 Other Coupling Techniques 277 11.6 Improving Sensitivity of DART-MS for Phytochemical Analysis 278 11.6.1 Solvents and Gases 278 11.6.2 Matrix Suppression 279 11.7 DART -MS as Process Analytical Technology 279 11.8 Future Perspective 280 References 280 12 Miscellaneous Applications of DART-MS 291Yoshihito Okada 12.1 Introduction 291 12.2 Usefulness of Negative-IonMode 292 12.3 Application to Archeology and Conservation 293 12.4 Application by Using TLC 293 12.5 Application to Low Volatility, ChemicalWarfare, and Homeland Security 294 12.6 Pheromone Profiles from Live Animals in Parallel with Behavior 295 12.7 Application to Distinction of Plants with Similarity 296 12.8 Application to Space 298 12.9 Application to Bituminous Coals 298 12.10 Application to Detection of Nicotine 298 12.11 Other Potential Applications of DART-MS 299 12.11.1 Instantaneous Screening for Counterfeit Drugs with No Sample Preparation [26-1] 299 12.11.2 Direct Analysis of Drugs in Pills and Capsules with No Sample Preparation [26-2] 300 12.11.3 Detection of Lycopene in Tomato Skin [26-3] 300 12.11.4 Distribution of Capsaicin in Chili Peppers [26-4] 302 12.11.5 Detection of Unstable Compound Released by Chopped Chives [26-5] 302 12.11.6 Rapid Detection of Fungicide in Orange Peel [26-6] 304 12.11.7 "Laundry Detective": Identification of a Stain [26-7] 304 12.11.8 Detection of the Peroxide Explosives TATP and HMTD [26-8] 306 12.11.9 Instantaneous Detection of Explosives on Clothing [26-9] 306 12.11.10 Rapid Detection and Exact Mass Measurements of Trace Components in a Herbicide [26-10] 308 12.11.11 Rapid Analysis of p-Phenylenediamine Antioxidants in Rubber [26-11] 308 Acknowledgment 309 References 309 13 Inherent Limitations and Prospects of DART-MS 313Tim T. Häbe, Matthias Nitsch, and Gertrud E. Morlock 13.1 Aspects of Inherent Limitations of DART-MS 313 13.1.1 Gas Settings 314 13.1.1.1 Type of Gas 314 13.1.1.2 Gas Temperature 314 13.1.1.3 Gas Flow Rate 317 13.1.2 Voltage of Electrodes 317 13.1.3 Sample Introduction and Positioning 318 13.1.4 Detection System and Mass Range 318 13.1.5 Matrix Effects and the Need for Chromatography 319 13.1.6 Buffer and Salt Effects 321 13.1.7 Sample Carrier and Solvent 322 13.1.8 Humidity Effects 322 13.1.9 Use of Isotopically Labeled Standards 322 13.1.10 Dopant and Derivatization 323 13.2 DART versus Other Ambient Ion Sources 324 13.3 Prospects of DART-MS 326 13.3.1 Automation and Miniaturized DART-MS 326 13.3.2 Sample Preparation, Preconcentration, and Introduction 327 13.3.3 Ion Focusing and Flexible Ion Transportation 327 13.3.4 Quantitative Surface Scanning and Imaging by DART-MS 328 13.3.5 Hyphenation of Effect-Directed Analysis and DART-MS 331 13.3.6 Thermal Separations by Temperature Gradients 331 13.3.7 Aerosol, in situ and in stillo Chemical Reaction and Kinetic Monitoring 332 13.3.8 High Resolution and Data Analysis 332 13.4 Concluding Remarks 333 References 333 Index 345
£999.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Food Chemistry
Book SynopsisFor more than two decades, this work has remained the leading advanced textbook and easy-to-use reference on food chemistry and technology. Its fourth edition has been extensively re-written and enlarged, now also covering topics such as BSE detection or acrylamide. Food allergies, alcoholic drinks, or phystosterols are now treated more extensively. Proven features of the prior editions are maintained: Contains more than 600 tables, almost 500 figures, and about 1100 structural formulae of food components - Logically organized according to food constituents and commodities - Comprehensive subject index. These features provide students and researchers in food science, food technology, agricultural chemistry and nutrition with in-depth insight into food chemistry and technology. They also make the book a valuable on-the-job reference for chemists, food chemists, food technologists, engineers, biochemists, nutritionists, and analytical chemists in food and agricultural research, food industry, nutrition, food control, and service laboratories. From reviews of the first edition "Few books on food chemistry treat the subject as exhaustively…researchers will find it to be a useful source of information. It is easy to read and the material is systematically presented." JACSTrade ReviewFrom the reviews of the third edition:“Food Chemistry does an excellent job of explaining the chemistry of food constituents as well as finished food products. … The book was written by food chemistry professors and is organized in the same way they teach their course. … All people can relate to food and it provides an excellent medium to present basic chemical principles. The wealth of knowledge in the book makes it a good reference book for anyone working in the field of food science.” (Sara J. Risch, Journal of Chemical Education, Vol. 89, 2012)"Has been extensively re-written and a number of new topics … have been introduced or completely revised. … This well-known and worldwide accepted advanced text and reference book is logically organised according to food constituents and commodities. It provides … up-to-date information. The extensive use of tables for easy reference, the wealth of information given, and the comprehensive subject index support the advanced student into getting in-depth insight into food chemistry and technology … ." (Food Trade Review, Vol. (74), June, 2004)"This world-wide well-known and classical reference book in the field of Food Chemistry has been extensively re-written. … logically organized according to the food constituents and commodities. It provides … up-to-date information in food chemistry. The extensive use of tables and the comprehensive subject index enables the advanced students to get an in-depth insight into both food chemistry and technology. But also for English-speaking professionals in these scientific fields … this up-to-date version is indispendable (sic) and, therefore, warmly recommended" (Advances in Food Sciences, Vol. 26(4), 2004)Table of ContentsWater.- Amino Acids, Peptides, Proteins.- Enzymes.- Lipids.- Carbohydrates.- Aroma Compounds.- Vitamins.- Minerals.- Food Additives.- Food Contamination.- Milk and Dairy Products.- Eggs.- Meat.- Fish, Whales, Crustaceans, Mollusks.- Edible Fats and Oils.- Cereals and Cereal Products.- Legumes.- Vegetables and Vegetable Products.- Fruits and Fruit Products.- Sugars, Sugar Alcohols and Honey.- Alcoholic Beverages.- Coffee, Tea, Cocoa.- Spices, Salt and Vinegar.- Drinking Water, Mineral and Table Water.
£104.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Chromatography of Aroma Compounds and Fragrances
Book SynopsisThe quantity and composition of aroma and avour compounds in foods and food products exert a marked in uence on the consumer acceptance and, consequently, on the commercial value of the products. It has been established many times that one of the main properties employed for the evaluation of the product quality is the avour, that is, an adequate avour composition considerably enhances the m- ketability. Traditional analytical methods are generally unsuitable for the accurate determination of the quantity of this class of compounds. Moreover, they do not contain any useful information on the concentration of the individual substances and they are not suitable for their identi cation. As the stability of the aroma compounds and fragrances against hydrolysis, oxidation and other environmental and tech- logical conditions shows marked differences, the exact determination of the avour composition of a food or food product may help for the prediction of the she- life of products and the assessment of the in uence of technological steps on the aroma compounds resulting in more consumer-friendly processing methods. Furthermore, the qualitative determination and identi cation of these substances may contribute to the establishment of the provenance of the product facilitating the authenticity test. Because of the considerable commercial importance of avour composition, much effort has been devoted to the development of methods suitable for the separation and quantitative determination of avour compounds and f- grancesinfoodsandinotherindustrialproducts.Trade ReviewFrom the reviews:“It explains how aroma compounds and fragrances are analyzed with chromatography. Designed to help scientists decide on the appropriate method, it compares the various choices and offers extensive data tables.” (American Herb Association Quarterly, Vol. 25 (4), 2011)“If you are in the field of smells and taints, both pleasant and unpleasant, and have not the time or inclination to search the literature then this would be a useful book to have as a reference.” (Edward R. Adlard, Chromatographia, Vol. 73, 2011)Table of ContentsChromatography of Aroma Substances and Fragrances.- Food and Food Products.- Essential Oils.- Biological Effect.- Environmental Pollution.
£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Career Management for Chemists: A Guide to Success in a Chemistry Career
Book SynopsisJohn Fetzer’s "Career Management for Chemists" provides ample, common-sense guidance on the key topics such as: Resumés and CVs, Staying Driven & Current, Personal Skills & Traits Networking, Teamwork & Leadership, Speaking & Listening Writing Research Papers, Mentoring, Behavior & Rewards The practical coverage reflects not only his long professional experience but also his insight that, especially in today’s changing workplace, expectations and strategies for career management require constant re-evaluation. Provides real, common-sense, and proven means to enrich and make more rewarding a technical career. Pre-publication comments from colleagues - "Not only the student who is taking his first steps in the scientific world would profit abundantly by mining this book for views and ideas on the different sides of his chosen career. Also the seasoned scientist will be stimulated to scrutinize his own habits and pick up new thoughts, thereby becoming a more skilled instructor of his younger colleagues." J. Andersson, University of Münster, Germany "As one of the international collaborators of Dr. John Fetzer, I want to warmly congratulate him. His efforts nicely summarize very important topics for all who work in scientific activities. But, at the same time, Career Management for Chemists also provides some real insights for many people who are not working in science. This is a nice guidebook on how to enrich our lives and help us to become more successful!! K. Jinno, Toyohashi University of Technology Trade ReviewFrom the reviews: This book has an incredibly broad scope and looks at both technical and non-technical areas, from keeping research records to dealing with difficult people. It is steeped in chemical terminology and anecdotes based on situations common to chemists, and so brings something fresh to the area. Fetzer himself stresses in the introduction that everyone works for themselves and that you can’t rely on anyone else to control or shape your career. Having established this essential truth, Fetzer shares his many years of experience in a style that is reassuring and supportive. Although more experienced chemists may find many of his points veer towards the ‘obvious’, younger scientists will find his insights on aspects such as conferences, collaboration and publishing invaluable in helping them understand how to be effective and have impact in the scientific community. For me, the book’s real strength lies in these sections, with it acting as a virtual mentor, sharing experiences and advice. The scope of the book is such that the individual topics can only be covered briefly, but as an experienced columnist, Fetzer captures the key points, which for most readers is all that is required. For example, scientists who are keen to develop their careers towards a management role will find the sections on dealing with others and working in and leading teams offer a practical summary of many management theories. The comprehensive bibliography points those interested to further information. ...The advice offered is universal and relevant to chemistry careers in the UK and internationally. I feel this book will have most value to chemists at the start of their careers as it distils many years on experience into straightforward tips on being an effective scientist. However, anyone seeking guidance or support for their professional life will find much of value in Fetzer’s encouraging and constructive book. Sara Shinton, Chemistry World, Vol. 1, No. 12, December 2004 "Career Management for Chemists provides ample, common-sense guidance on the key topics such as resumes and CVs, staying driven and current, personal skills and traits networking, teamwork and leadership, speaking and listening, writing research papers, behavior and rewards. … reflects not only his long professional experience but also his insight that, especially in today’s changing workplace, expectations and strategies for career management require constant reevaluation." (cpp 2005, Issue no. 2, 2005) "A useful handbook for chemists at all levels and at all career stages. … Not only are the chosen topics thought-provoking … but consideration of such would be advantageous for any scientist to keep in mind while journeying through the years of a career. … None of the career management books offers the combination of topics that Fetzer does, with the emphasis on one’s career as a journey … . would be useful for recent graduates … ." (Mary B. Satterfield, Analytical and Bioanalytical Chemistry, March, 2005) "John Feltzer believes that to be a good scientist one needs more than just good technical knowledge and research skills. … He explains how to achieve in technical area by keeping on learning; being part of a scientific community; writing and reviewing for journals; diversifying etc." (Book News on the Internet, January, 2005) "This is generally an almost exclusive view of the USA experience of science employment. … Finding mentors (or being a mentor), how to deal with negative situations, learning not to fight a battle under your opponent’s rules, how to avoid having one’s ethics compromised by others, moving from "pure" science into management, are topics all covered in various chapters. … A thorough reading, followed by regular re-reads as one’s career develops, will almost certainly significantly enhance almost anyone’s career pattern." (K. Jones, Chromatographia, Vol. 61(1-2), 2005) "This book has an incredibly broad scope and looks at both technical and non-technical areas, from keeping research records to dealing with difficult people. It is steeped in chemical terminology and anecdotes based on situations common to chemists … . will have most value to chemists at the start of their careers … . anyone seeking guidance or support for their professional life will find much of value in Fetzer’s encouraging and constructive book." (Sara Shinton, Chemistry World, Vol. 1(12), December, 2004) "In a truly scientific way, Fetzer begins by exploring the technical requirements for a specialist scientific career. … Fetzer clearly identifies … issues, such as communication … resume and interview preparation, skills assessment, teamwork and leadership. … In clear text he leads the reader through each aspect, providing pertinent examples, many from his own experiences. … The book is most readable and will provide useful guidance for all chemists … ." (Alan French, Chemistry in Australia, November, 2004) "John Fetzer’s … provides ample, common-sense guidance on the key topics such as: Resumes and CVs, Personal Skills & Traits Networking, Teamwork & Leadership, Speaking & Listening, Writing Research Papers, Mentoring, Behavior & Rewards. … reflects not only his long professional experience but also his insight that, especially in today’s changing workplace, expectations and strategies for career management require constant re-evaluation." (PROCESS Chemical and Pharmaceutical Engineering, Vol. 7(3), 2004) Table of ContentsAcknowledgements 1 Introduction – The career as a long trip 2 Technical Areas 2.1 Accepting Failure to Create Innovation in Experimentation 2.2 Keeping current – always learning 2.3 Specialist or Generalist? 2.4 Being a Part of the Scientific Community 2.4.1 General Remarks 2.4.2 Societies – Is it advantageous to belong to professional societies 2.4.3 Being Involved in Societies 2.4.4 Conferences – Is it advantageous to attend and present at conferences? 2.4.5 Journals and other Publications – Is it advantageous to publish papers? 2.4.6 Reviewing for Journals 2.4.7 Advisory Boards and Editorships 2.5 Thinking – Curiosity and Wonder 2.6 Thinking – Scepticism 2.7 Diversifying 2.8 Parochial science – Possessiveness and Boundaries 2.9 The Tools (Part 1) – Tools and mechanics of research: Putting together your toolbox 2.10 The Tools (Part 2) – Handy tools, but not always needed 3 Non-technical Areas 3.1 Communicating 3.1.1 The general common points 3.1.2 Eloquence – Speaking Easily the First time 3.1.3 Writing a paper – The basic mechanics help 3.1.5 Listening 3.2 Networking – Becoming an integral part of your field 3.3 Collaborative Research 3.4 Diversity in Science – Being open minded 2.5 Using a mentor – Help Wanted: Sage and Wise Chemists to help guide 3.6 Being a mentor 3.7 Behaviours 3.7.1 Personalities and Styles in Dealing with Others 3.7.2 Dealing with Those on the Dark Side – difficult and worse people 3.7.3 Ethics – The Right Things to Do 3.8 Teams, Teamwork and Leadership 3.9 Balancing professional and private time 4 Career Changes 4.1 The Rewards or working in industry – Starting and choosing a direction from graduate school to an industrial career 4.2 Industry versus academia – The Merits of an Industrial Career in Contacts to one in Academia 4.3 Resume and curriculum vita – Getting the messageacross 4.4 The grass is greener – A Comparison Between Workplaces 4.5 Changing hats – supervising and managing 4.6 Personal skills and assessments 4.7 Degree of difficulty – non-advanced degree chemists 4.8 Pursuit of Non-traditional Careers in Chemistry 5 Bibliography
£71.24
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Kapillarelektrophorese: Methoden und Möglichkeiten
Table of Contents1 Einleitung.- 2 Grundlagen der Kapillarelektrophorese.- 3 Theoretische Grundlagen und ihr Einfluß auf das analytische Ergebnis.- 3.1 Elektrophoretische Wanderung.- 3.2 Leitfähigkeit.- 3.3 Elektroosmotischer Fluß.- 3.4 Bandenverbreiterung.- 3.4.1 Effizienzverluste durch Diffusion.- 3.4.2 Effizienzverluste durch Temperatureffekte.- 3.4.3 Effizienzverluste durch Elektrodispersion.- 3.4.4 Effizienzverluste durch Wandadsorption.- 3.4.5 Effizienzverluste durch Überladung des Trennsystems.- 3.4.6 Effizienzverluste durch Überlagerung von Strömungsprofilen.- 3.4.7 Zusammenfassung.- 4 Apparatur.- 4.1 Spannungsquelle.- 4.2 Kapillaren.- 4.3 Probenaufgabe.- 4.3.1 Druck-Injektion.- 4.3.2 Hydrostatische Injektion.- 4.3.3 Elektrokinetische Injektion.- 4.3.4 Probensplitsysteme.- 4.3.5 Anreicherungseffekte bei der Probenaufgabe (Sample Stacking).- 4.4 Thermostatisierung.- 4.5 Detektion.- 4.5.1 UV-Detektion.- 4.5.2 Fluoreszenzdetektion.- 4.5.3 Weitere Detektionsmethoden.- 4.6 Spezielle Probleme der quantitativen Analyse in der CE.- 5 Kapillarzonenelektrophorese (CZE).- 5.1 Grundlagen der Optimierung in der CZE.- 5.1.1 Einfluß des pH-Wertes.- 5.1.2 Einfluß der Pufferkonzentration.- 5.1.3 Auswahl des Puffers.- 5.1.4 Anwendungen.- 5.2 Indirekte Detektionsmethoden in der CE.- 5.2.1 Grundlagen indirekter Detektionstechniken.- 5.2.2 Trennung von Kationen mit indirekter UV-Detektion.- 5.2.3 Trennung von Anionen mit indirekter UV-Detektion.- 5.2.4 Analyse von Kationen und Anionen mit indirekter Fluoreszenzdetektion.- 5.3 Kapillarzonenelektrophorese von Proteinen.- 5.3.1 Trennungen in unbeschichteten Kapillaren.- 5.3.1.1 Auswahl des pH-Wertes.- 5.3.1.2 Zugabe von Salzen zum Puffer.- 5.3.1.3 Verwendung von Pufferzusätzen zur Trennung von Proteinen.- 5.3.1.4 Dynamische Belegung von Kapillaren.- 5.3.2 Proteintrennungen mit oberflächenmodifizierten Kapillaren.- 5.3.2.1 Beschichtungen für die Kapillarelektrophorese.- 5.3.3 Überblick über wichtige chemische Beschichtungen für die Proteintrennung.- 5.3.3.1 Konventionelle Beschichtungen.- 5.3.3.2 Polymere Beschichtungen.- 5.3.4 Zusammenfassung.- 6 Micellare Elektrokinetische Chromatographie (MEKC).- 7 Trennung von Enantiomeren in der CE.- 7.1 Enantiomerentrennungen mit Hilfe von Cyclodextrinen als chirale Selektoren.- 7.1.1 Neutrale Cyclodextrine.- 7.1.2 Ionische Cyclodextrine.- 7.2 Andere Trennsysteme.- 8 Kapillar-Gelelektrophorese (CGE).- 8.1 Gele auf Acrylamid-Basis.- 8.1.1 Herstellung und Handhabung gelgefüllter Kapillaren.- 8.1.2 Quervernetzte Polyacrylamidgele.- 8.1.3 Lineare Polyacrylamidgele (LPA).- 8.1.3.1 Trennung von DNA-Fragmenten mit LPA.- 8.1.3.2 SDS PAGE (Polyacrylamid-Gelelektrophorese) von Proteinen.- 8.2 Gele auf Polysaccharidbasis und anderen Polymeren.- 8.3 Migrationsmodelle von Biopolymeren in Polymerlösungen.- 9 Isoelektrische Fokussierung in Kapillaren (CIEF).- 10 Andere Trenntechniken in der CE.- 10.1 Isotachophorese (ITP).- 10.2 Elektrochromatographie (EC).- 11 Anleitung zur Fehlersuche in der CE.- 11.1 Bestimmung der Fehlerursache.- Test 1: Aufnahme einer Durchbruchskurve unter Spüldruck.- Test 2: Aufnahme einer Durchbruchskurve mit Injektionsdruck.- Test 3: Überprüfung der Spannungsquelle.- 11.2 Störfallszenarien: „Was tun, wenn…“.- 12 Literaturverzeichnis.- 12.1 Zitierte Literatur.- 12.2 Weiterführende Literatur.- 12.3 Bezugsquellenverzeichnis.- 13 Danksagung.- Sachwortverzeichnis.
£44.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Chemische Sensoren: Funktion, Bauformen, Anwendungen
Table of ContentsInhaltsübersicht.- 1 Historische Entwicklung chemischer Sensoren.- 2 Definition und Kennzeichnung chemischer Sensoren.- 2.1 Definitionen.- 2.2 Aufnehmer.- 2.3 Chemische Parameter.- 2.4 Kennzeichnung chemischer Sensoren.- 2.4.1 Meßbereiche.- 2.4.2 Selektivität.- 2.4.3 Drift der Sensorsignale.- 2.4.4 Ansprechzeiten.- 2.4.5 Fehlerangaben und Fehlerursachen.- 2.4.6 Betriebsbedingungen.- 2.4.7 Lebensdauerbetrachtungen.- 3 Konzentrationsangaben.- 4 Technologien zur Fertigung chemischer Sensoren.- 5 Elektrochemische Sensoren.- 5.1 Einleitung.- 5.2 Konduktometrie.- 5.2.1 Grundlagen der Konduktometrie.- 5.2.2 Begriffe und Definitionen.- 5.2.3 Konduktometrische Sensoren.- 5.3 Potentiometrie.- 5.3.1 Grundlagen der Potentiometrie.- 5.3.2 Begriffe und Definitionen.- 5.3.3 Potentiometrische Sensoren.- 5.3.4 Sensoren für die Direkt-Potentiometrie.- 5.3.5 Bezugselektroden.- 5.3.6 pH-Meter und Ionen-Meter.- 5.4 CHEMFETs.- 5.4.1 Einleitung.- 5.4.2 Methodische Grundlagen.- 5.4.3 CHEMFET-Fertigung und -Bauformen.- 5.4.4 ISFET-Eigenschaften.- 5.4.5 Ausblick.- 5.5 Amperometrie.- 5.5.1 Begriffe und Definitionen.- 5.5.2 Grundlagen der Amperometrie.- 5.5.3 Amperometrische Sensoren.- 6 Festkörper-Gassensoren.- 6.1 Einleitung.- 6.2 Halbleiter-Gassensoren.- 6.2.1 Der Begriff des Halbleiters.- 6.2.2 Meßtechnische Grundlagen.- 6.2.3 Sensoren mit Oberflächenleitfähigkeit.- 6.2.4 Sensoren mit Volumenleitfähigkeit.- 6.3 Ionenleitende Gassensoren.- 6.3.1 Der Begriff des Festelektrolyten.- 6.3.2 Aufbau und Funktion von Sauerstoffsensoren.- 6.3.3 Weitere ionenleitende Sensoren.- 6.4 Thermokatalytische Sensoren.- 6.4.1 Methodische Grundlagen und Bauformen.- 6.4.2 Sensormerkmale und Einsatzgebiete.- 7 Faseroptische Sensoren.- 7.1 Glasfasern zur Signalübertragung.- 7.2 Glasfaser-Refraktometer.- 7.3 Kolorimetrische faseroptische Sensoren.- 7.4 Fluorometrische faseroptische Sensoren.- 7.5 Bewertung faseroptischer Sensoren.- 8 Ionisations-Sensoren.- 8.1 Einleitung.- 8.2 Flammenionisations-Sensoren (FID).- 8.3 Photoionisations-Sensoren (PID).- 8.4 Bewertung von Ionisations-Sensoren.- 9 Piezoelektrische Gassensoren.- 9.1 Einleitung.- 9.2 Chemische Sensitivierungen.- 9.3 Bewertung von piezoelektrischen Sensoren.- 10 Sonstige chemische Sensoren.- 10.1 Einleitung.- 10.2 Gasanalysen durch Mesung der Wärmeleitfähigkeit.- 10.2.1 Methodische Grundlagen.- 10.2.2 Anwendungen.- 10.3 Paramagnetische Sauerstoffmessung.- 10.3.1 Methodische Grundlagen.- 10.3.2 Anwendungen.- 10.4 Dichtemessung von Lösungen.- 10.4.1 Methodische Grundlagen.- 10.4.2 Anwendungen.- 10.5 Messung der Schallgeschwindigkeit von Lösungen.- 10.5.1 Methodische Grundlagen.- 10.5.2 Anwendungen.- 10.6 Spektralphotometrische Methoden.- 10.6.1 Einleitung.- 10.6.2 Methodische Grundlagen.- 10.6.3 Geräte und Anwendungen.- Sachwortverzeichnis.- 1: Sensortechnik.- 2: Anwendung von Sensoren.
£54.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Anleitung zur Erkennung, Prüfung und Wertbestimmung der gebräuchlichsten Chemikalien für den technischen, analytischen und pharmaceutischen Gebrauch
Table of ContentsA.- B.- C.- D.- E.- F.- G.- H.- I.- J.- K.- L.- M.- N.- O.- P.- R.- S.- T.- U.- V.- X.- Z.
£45.99
Springer Spektrum Unraveling PFASMicroplastic Interactions
Book SynopsisIntroduction.- Experimental.- Results and Discussion.- Conclusion and Outlook.
£71.24
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Grundlagen für den Nachweis von Giftstoffen bei gerichtlich-chemischen Untersuchungen. Für Chemiker, Pharmazeuten und Mediziner
£59.99
Springer Fachmedien Wiesbaden Spektroskopische Daten zur Strukturaufklärung organischer Verbindungen
£37.99
Springer A Guide to Protein Isolation
Book SynopsisIt is a truism of science that the more fundamental the subject, the more universally applicable it is. Nevertheless, it is important to strike a level of “fundamentalness” appropriate to the task in hand. For -depth study of the mechanics of motor cars would tell one example, an in nothing about the dynamics of traffic. Traffic exists on a different “level” - it is dependent upon the existence of motor vehicles but the physics and mathematics of traffic can be adequately addressed by considering motor vehicles as mobile “blobs”,with no consideration of how they become mobile. To start a discourse on traffic with a consideration of the mechanics of motor vehicles would thus be inappropropriate. In writing this volume, I have wrestled with the question of the appropriate level at which to address the physics underlying many of the techniques used in protein isolation. I have tried to strike a level as would be used by a mechanic (with perhaps a slight leaning towards an engineer) - i.e. a practical level, offering appropriate insight but with minimal mathematics. Some people involved in biochemical research have a minimal grounding in chemistry and physics and so I have tried to keep it as simple as possible.Table of ContentsAcknowledgements. Preface. 1. An overview of protein isolation. 2. Assay, extraction and sub-cellular fractionation. 3. Concentration of the extract. 4. Chromatography. 5. Electrophoresis. 6. Immunological methods. Index.
£44.99
Amazon Digital Services LLC - Kdp Metal Complexes
£32.49
Amazon Digital Services LLC - Kdp Chiral Ionic Liquids
£48.04
Amazon Digital Services LLC - Kdp Organic Spectroscopy Technology and Applications
£39.78
Springer Laboratory Techniques for Fish Disease Diagnosis
Book Synopsis1. An overview of sample collection and standard necropsy procedures for fish.- 2. Biosafety, Sterilization, and Disinfection Protocols.- 3. Common Staining Techniques in Laboratories.- 4. In vitro Susceptibility Assays for Bacterial Response to Antimicrobial Agents.- 5. Quality Assurance in Laboratory Practices and Equipment Maintenance: Ensuring Precision, Reliability, and Compliance.- 6. Methodological Approaches to Assess Innate Immune Responses of Fish.- 7. Fundamentals of innate immune system of shrimp.- 8. Disease in shrimp aquaculture: diagnostic technique for sustainable management.- 9. Fish Disease Diagnosis Methods: Assessment and Possible Applications.- 10. Genomic Approaches to Validate the Pathogenicity of Bacterial Fish Pathogens.- 11. Diagnostic techniques for fish Fungal Diseases.- 12. Disease Diagnosis and Control in Marine Fish Aquaculture.- 13. Molecular Techniques in Diagnosis of Fish Parasitic Infection.- 14. Hematological Techniques for Diagnosis of Fish Diseases.- 15. The Challenges of PCR Amplification in Disease Diagnosis.- 16. Histological Techniques in Fish Disease Diagnosis.- 17. Sensing Techniques for Microbial Pathogens.- 18. Hormonal regulation and disorder during fish disease.- 19. Applications of Monoclonal Antibodies for Detection of Fish Pathogens.- 20. Nanotherapeutics: An Approach for Fish Disease Treatment.- 21. Detection and Quantification of Tilapia Lake Virus (TiLV) and Tilapia Parvovirus (TiPV) by Real-Time PCR.- 22. Role of Artificial Intelligence in Fish Disease Modeling and Prognosis.- 23. Introduction to Microplastics: A Global Perspective of an Alarming Contaminant in the Aquatic Ecosystem.- 24. Emerging Challenges of Extended-Spectrum ß-Lactamase Producing Pathogen: Laboratory Strategies for Detection.- 25. eDNA Approaches for Ecosystem Health Monitoring: Focus on Pathogens, Vectors, and Microbial Assessment.1. An overview of sample collection and standard necropsy procedures for fish.- 2. Biosafety, Sterilization, and Disinfection Protocols.- 3. Common Staining Techniques in Laboratories.- 4. In vitro Susceptibility Assays for Bacterial Response to Antimicrobial Agents.- 5. Quality Assurance in Laboratory Practices and Equipment Maintenance: Ensuring Precision, Reliability, and Compliance.- 6. Methodological Approaches to Assess Innate Immune Responses of Fish.- 7. Fundamentals of innate immune system of shrimp.- 8. Disease in shrimp aquaculture: diagnostic technique for sustainable management.- 9. Fish Disease Diagnosis Methods: Assessment and Possible Applications.- 10. Genomic Approaches to Validate the Pathogenicity of Bacterial Fish Pathogens.- 11. Diagnostic techniques for fish Fungal Diseases.- 12. Disease Diagnosis and Control in Marine Fish Aquaculture.- 13. Molecular Techniques in Diagnosis of Fish Parasitic Infection.- 14. Hematological Techniques for Diagnosis of Fish Diseases.- 15. The Challenges of PCR Amplification in Disease Diagnosis.- 16. Histological Techniques in Fish Disease Diagnosis.- 17. Sensing Techniques for Microbial Pathogens.- 18. Hormonal regulation and disorder during fish disease.- 19. Applications of Monoclonal Antibodies for Detection of Fish Pathogens.- 20. Nanotherapeutics: An Approach for Fish Disease Treatment.- 21. Detection and Quantification of Tilapia Lake Virus (TiLV) and Tilapia Parvovirus (TiPV) by Real-Time PCR.- 22. Role of Artificial Intelligence in Fish Disease Modeling and Prognosis.- 23. Introduction to Microplastics: A Global Perspective of an Alarming Contaminant in the Aquatic Ecosystem.- 24. Emerging Challenges of Extended-Spectrum ß-Lactamase Producing Pathogen: Laboratory Strategies for Detection.- 25. eDNA Approaches for Ecosystem Health Monitoring: Focus on Pathogens, Vectors, and Microbial Assessment.
£66.97
Springer Extracellular Fine Particles
Book SynopsisExtracellular fine fiber-induced carcinogenesis and its prevention.- Toward Digital Bioanalysis of Extracellular Vesicles.- Mechanisms of asymmetrical exosome release from polarized epithelial cells: implications for the molecular basis of exosomal heterogeneity.- Control of the particle trafficking and dynamics of the lymphatic system and of the cellular microenvironment.- Elucidation of the mechanisms that regulate the quantity and quality of exosomes un cancer.- Membrane dynamics of exosomes as revealed by sin-gle-molecule imaging.- Glycan remodeling by small extracellular vesicles.- Analysis of immune responses induced by inhaled fine particulates.- Harnessing DNA and Energy Cargo: Unveiling the Active Biogenesis and Applications of Bacterial Extracellular Vesicles.- Macropinocytosis and the related actin-driven cellular uptake pathways for extracellular fine particles.- Relationship between bio-distribution of environmental particles and induction of biological and immune response in the respiratory system.- Direct observation of biological fine particles in water by scanning electron assisted dielectric microscopy.- Pathways to repair or remove lysosomes damaged by extracellular fine particles.- Neurodegenerative disorder and fine particulate matter.- Extracellular vesicle isolation and analysis using nanowires.- Particulars of Oral Cavity.- High dimensional cytometry for studying heterogeneous small particles.- Magnetic nanoparticles for diagnostics and therapy.- Engineered and artificial exosomes for non-viral drug delivery nanocarriers.
£170.99
Independently Published Formules moles et réactions
£9.41
Independently Published Azul de metileno y DMSO para perros y gatos
£14.78
Independently Published Understanding Empower 3
£63.88
Amazon Digital Services LLC - Kdp HPLC and UHPLC Unveiled
£15.03
Elsevier - Health Sciences Division Molecular and Laser Spectroscopy
Book SynopsisTable of ContentsMolecular Spectroscopy - Linear and Non-Linear 1. Introduction and overview 2. Advanced Spectral Analysis of Complex Molecular System 3. Tip-enhanced Raman spectroscopy for optical nano-imaging 4. Chiroptical spectroscopy techniques for asymmetric reactions 5. Miniaturized Near-Infrared Spectroscopy in Natural Product Analysis. Current and future directions. 6. Near-infrared spectroscopy for medical, food and forage applications 7. Thin Layer Chromatography-Surface Enhanced Raman Scattering (TLC-SERS) Advanced Instrumentation and Applications 8. Raman Integrated Optical Photothermal Infrared Microscopy 9. Fourier transform infrared, optical photothermal infrared and Raman spectroscopy for detection of microplastic particles 10. Plasmonic nano-sensors and their spectroscopic applications - Current trends and future perspectives Biochemical and Medical Applications 11. Applications of SERS in biochemical and medical analysis 12. IR spectroscopy and imaging using polarized light with QCLs 13. Terahertz spectroscopy of biological molecules in solid, liquid, and gaseous states. Time-resolved and Ultrafast Spectroscopy 14. Step-scan FTIR Spectroscopy (absorption and emission) for detecting Reaction Intermediates 15. Spectral and kinetic investigations of gaseous transient species with quantum-cascade laser 16. Ultrafast spectroscopy of the transition state: Real-time tracking of the molecular structural dynamics of photochemical pathways using vibrational spectroscopy techniques 17. Ultrafast Infrared Probes of Electronic Processes in Materials
£157.50
Taylor & Francis Inc OrganoClay Complexes and Interactions
Book SynopsisProvides comprehensive coverage of the structures, properties, and interactions of organo-clay complexes as well as their role in the origin of life. Presents current techniques in nuclear magnetic resonance, differential thermal analysis and thermogravimetry, visible spectroscopy, and infrared and thermal-infrared spectroscopy for the analysis of fine structures in organo-clay complexes.Table of ContentsStructure and surface acidity of clay minerals; introduction to organo-clay complexes and interactions; interactions of vermiculites with organic compounds; organophilicity and hydrophobicity of organo-clays; adsorption of organic cations on clays - experimental results and modelling; nuclear magnetic resonance spectroscopy; thermal analysis of organo-clay complexes; IR-spectroscopy and thermo-IR-spectroscopy in the study of the fine structure of organo-clay complexes; staining of clay minerals and visible-absorption spectroscopy of dye-dye complexes; clay catalysis in reactions of organic matter; organo-materials and organo-clay interactions and the origin of life on Earth.
£285.00
Taylor & Francis Inc Electrokinetic Phenomena Principles and
Book SynopsisElectrokinetic Phenomena emphasizes the impact of methods such as capillary zone electrophoresis, capillary electrochromatography, and capillary gel electrophoresis on the analysis of biomolecules. This reference reveals the electrokinetic phenomena that underlie high-performance electro-based analytical tools and vividly depicts how electrodriven analytical tools revolutionize and expedite chemical, pharmaceutical, and biotechnological analysis. An authoritative overview, the book provides effective pathways for large-scale biomedical applications and describes how microfabricated and automated devices enhance and accelerate the analysis of biologically important molecules.Table of Contents Migration of sample components in capillary analytical techniques - chromatography, electrophoresis, and electrochromatography, Anurag S. Rathore; methods development for capillary electrophoresis with emphasis on small molecules, Robert Weinberger; capillary isoelectric focusing, Ferenc Kilar; capillary gel electrophoresis and related microseparation techniques Andras Guttman; affinity capillary electrophoresis, Vadim M. Okun and Ernst Kenndler; electroosmotic mobility and conductivity in microchannels, Emily Wen, Anurag S. Rathore and Csaba Horvath; factors influencing performance in capillary electrochromatography on silica columns, Keith D. Bartle and Peter Myers; effects of pore flow on separation efficiency in capillary electrochromatography with porous particles, Remco Stol and Wim Th. Kok; ultrashort-column capillary electrochromatography, Takao Tsuda; microstructure and in-silico developments for high-sensitivity proteomics research, Thomas Laurell, Johan Nilsson and Gyorgy Marko-Varga; micro chemical processing on microchips, Yoshikuni Kikutani and Takehiko Kitamori; micropreparative applications and on-line sample treatment, Julia Khandurina; NMR detection in capillary electrophoresis and capillary electrochromatography, Dimuthu A. Jayawickrama, Andrew M. Wolters and Jonathan V. Sweedler; applications of capillary electrochromatography, V.T. Remcho, Gabriela S. Chirica, Stacey L. Clark and Angela Doneau; clinical applications of microfluidic devices, Joan M. Bienvenue, James Karlinsey, James P. Landers and Jerome P. Ferrance.
£237.50
