Therapy and therapeutics Books

Book SynopsisSelected as a Doody’s Core Title for 2023! The Washington Manual® of Medical Therapeutics, 37th Edition, provides essential information you need for successful patient care, with concise, high-yield content that reflects today’s fast-changing advances in medical technology and therapeutics. Written by faculty, residents, and fellows and edited by chief residents of the distinguished Washington University School of Medicine in St. Louis, the Washington Manual presents brief, logical approaches to diagnosis and management of commonly encountered medical conditions, including new therapies that improve patient outcomes. Discover why housestaff and faculty around the world depend on this best-selling resource for day-to-day clinical practice in internal medicine. Provides comprehensive coverage of many areas of medicine and the core subspecialties—all at your fingertips for quick review and reference Features a new, colorful presentation with easy-to-follow guidelines, tables, diagrams, and dosing and treatment information Includes easy-to-use algorithms for fast visual guidance Addresses challenges that residents, interns, medical students, and other practitioners confront every day Features content carefully edited by Internal Medicine Chief Residents from the Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

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Book SynopsisThis textbook provides a structured, informed approach to the understanding and appreciation of drug action and effect providing a detailed description and discussion of pharmacokinetics and pharmacodynamics for nurses.The text focuses and emphasizes safe prescribing and administration of medication highlighting the possible harm to patient in terms of adverse reactions.This book also includes the seldom addressed facet of pharmacotherapeutics; drug formulation as applied to practice, and adverse reactions. It informs on the medication used to manage diabetes mellitus, respiratory disease, gastrointestinal tract, the central nervous system and many other affections.Uniting these essential pharmacological processes and applying them to physiological system based medications, this work highlights issues relevant to drug interaction and important nursing responsibilities associated with administration/prescribing. The overall aim of the text is to equip the nurse with an understanding of issues related to pharmacotherapeutics that is aligned to current nursing roles and statutory requirements. Table of ContentsPrefaceSection 1: Legal and ethical issues 01 Legal and ethical issues associated with medication - Sherri Ogston-Tuck Sherri Ogston-Tuck Section 2: Principles of pharmacology 02 Pharmacokinetics and pharmacodynamics - Ehsan Khan 03 Drug Formulations - Ali A. Dahab 04 Adverse Drug Reactions and Drug Interactions - Nicola Husain Section 3: Systemic pharmacology 05 Pharmacology of pain - Sheila Turner 06 Antimicrobials - Edward Purssell 07 Medications used for the Cardiovascular system - Joan Adams ; Dr Ehsan Khan 08 Medications used for the Renal system - Roseline Elsie Agyekum 09 Medications used for Diabetes Melitus - Haya Abu Ghazaleh; Dr. Ehsan Khan 10 Medications used for the Respiratory system - Shelley Peacock 11 Medications used for the Gastro-intestinal system – Dr. Ehsan Khan 12 Medications used for the Central nervous system – Dr. Ehsan Khan 13 Medications used for Mental health illness – Dr. Ehsan Khan 14 Medications used for Cancer - Mary Anne L. Tanay

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Book SynopsisThis book critically reviews 75 important published papers that influence the practice of geriatric psychiatry. This book will assist anyone who is interested in the care of older adults with psychiatric disorders. It was written by thought leaders who shape the way geriatric psychiatry is currently practiced in the United States. All the major psychiatric disorders in later life are covered including anxiety disorders, bipolar disorders, depressive disorders, neurocognitive disorders, psychotic disorders, sleep disorders, and substance use disorders. It also reviews important studies on suicides in late life and interventional procedures in geriatric psychiatry like the ECT, and also evaluates the adverse effects of psychotropic medications on older adults with psychiatric disorders. The editors of the book along with input from members of the teaching and training committee of the American Association for Geriatric Psychiatry (AAGP) have chosen 75 published papers from the field of geriatric psychiatry that they believe provides the highest knowledge-yield/impact for practicing clinicians and educators in the field of geriatric mental health. The AAGP is a national association that represents and serves its members and the field of geriatric psychiatry. These 75 papers are critically appraised by the members of AAGP using a standardized format and a summary of these papers and their practical application is provided by these experts. This information can be used by anyone who wants to learn about the field of geriatric psychiatry.Table of ContentsSection 1: Adverse effects of medications.- Do atypical antipsychotics cause stroke?.- Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials.- Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons.- The efficacy and safety of atypical antipsychotics for the treatment of dementia: a meta-analysis of randomized placebo-controlled trials.- Do antipsychotics lead to cognitive impairment in dementia? A meta-analysis of randomised placebo-controlled trials.- A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias.- Section 2: Anxiety Disorders.- Treatment of panic disorder in older adults: a pilot study comparison of alprazolam, imipramine, and placebo.- Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial.- Efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder: a pooled analysis of four randomized, double-blind, placebo-controlled studies.- Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial.- Meta-analysis Comparing Different Behavioral Treatments for Late-Life Anxiety.- Cognitive Behavior Therapy for Generalized Anxiety Disorder Among Older Adults in Primary Care: A Randomized Clinical Trial.- Stepped-care prevention of anxiety and depression in late life: a randomized controlled trial.- A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder.- Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults.- A meta-analysis of cognitive functioning in older adults with PTSD.- Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis.- Section 3: Bipolar Disorder.- A Pilot Study of Standardized Treatment in Geriatric Bipolar Disorder.- Differences in clinical features and mental health service use in bipolar disorder across the lifespan.- Effect of antidepressant use on admissions to hospital among elderly bipolar patients.- GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.- History of Bipolar disorder and the risk of dementia: A systematic review and meta-analysis.- Section 4. Delirium.- A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients.- Delirium in elderly patients and the risk of post discharge mortality, institutionalization, and dementia: a meta-analysis.- Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis.- Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis.- Interventions for preventing delirium in older people in institutional long‐term care.- Section 5: Depressive Disorders.- Nortriptyline and Interpersonal Psychotherapy as Maintenance Therapies for Recurrent Major Depression. A Randomized Controlled Trial in Patients Older Than 59 Years.- Continuation treatment of delusional depression in older adults.- Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial.- Remission in Depressed Geriatric Primary Care Patients: A Report from the PROSPECT Study.- Executive dysfunction and the course of geriatric depression.- Maintenance Treatment of Major Depression in Old Age.- Placebo-Controlled Study of Relapse Prevention With Risperidone Augmentation in Older Patients with Resistant Depression.- Efficacy of Second-Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence.- A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD).- Speed of remission in elderly patients with depression: electroconvulsive therapy v. medication.- A systematic review and meta-analysis of psychotherapy for late-life depression.- A novel strategy for continuation ECT in geriatric depression: phase 2 of the PRIDE Study.- Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.- Improvement in Depression is Associated with Improvement in Cognition in Late-Life Psychotic Depression.- Section 6: Electroconvulsive Therapy.- Continuation/Maintenance Treatment with Nortriptyline Versus Combined Nortriptyline and ECT in Late-Life Psychotic Depression: A Two-Year Randomized Study.- Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia.- Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study.- Electroconvulsive Therapy and Risk of Dementia-A Nationwide Cohort Study in Taiwan.- Section 7: Grief.- Treatment of complicated grief in elderly persons: a randomized clinical trial.- Section 8: Pain Disorders.- Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-Analysis.- Section 9: Psychotic Disorders.- A Randomized, Controlled Trial of Cognitive Behavioral Social Skills Training for Middle-Aged and Older Outpatients with Chronic Schizophrenia.- Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: a double-blind, placebo-controlled study with six-month open-label extension.- Antipsychotic treatment for elderly people with late-onset schizophrenia.- Schizophrenia and risk of dementia: A meta-analysis study.- Antipsychotic treatment of very late-onset schizophrenia-like psychosis (ATLAS): a randomised, controlled, double-blind trial.- Section 10: Neurocognitive Disorders.- Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis.- Depression and risk for Alzheimer disease: Systematic review, Meta-analysis, and Metaregression analysis.- Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease.- Predictors of progression from mild cognitive impairment to Alzheimer disease.- Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis.- Personality and risk of Alzheimer’s disease: New data and meta-analysis.- Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis.- Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis.- Meta-analysis of modifiable risk factors for Alzheimer’s disease.- Memantine for Alzheimer's Disease: An Updated Systematic Review and Meta-analysis.- Update on the Risk of Motor Vehicle Collision or Driving Impairment with Dementia: A Collaborative International Systematic Review and Meta-Analysis.- Pharmacological interventions for apathy in Alzheimer's disease.- Section 11: Sleep Disorders.- Behavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial.- Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.- Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.- Cognitive behavior therapy for older adults with insomnia and depression: a randomized controlled trial in community mental health services.- Section 12: Suicides.- Medical Illness and the Risk of Suicide in the Elderly.- The Risk of Suicide with Selective Serotonin Reuptake Inhibitors in the Elderly.- Section 13: Substance Use Disorders.- Naltrexone as an Adjunctive Treatment for Older Patients with Alcohol Dependence.- Older adult patients with both Psychiatric and Substance abuse disorders: Prevalence and Health service use.- Five-year alcohol and drug treatment outcomes of older adults versus middle-aged and younger adults in a managed care program.- Treatment of Late-Life Depression Complicated by Alcohol Dependence.- Screening and Brief Intervention for Substance Misuse Among Older Adults: The Florida BRITE Project.

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Book SynopsisThis book critically reviews 75 important published papers that influence the practice of geriatric psychiatry. This book will assist anyone who is interested in the care of older adults with psychiatric disorders. It was written by thought leaders who shape the way geriatric psychiatry is currently practiced in the United States. All the major psychiatric disorders in later life are covered including anxiety disorders, bipolar disorders, depressive disorders, neurocognitive disorders, psychotic disorders, sleep disorders, and substance use disorders. It also reviews important studies on suicides in late life and interventional procedures in geriatric psychiatry like the ECT, and also evaluates the adverse effects of psychotropic medications on older adults with psychiatric disorders. The editors of the book along with input from members of the teaching and training committee of the American Association for Geriatric Psychiatry (AAGP) have chosen 75 published papers from the field of geriatric psychiatry that they believe provides the highest knowledge-yield/impact for practicing clinicians and educators in the field of geriatric mental health. The AAGP is a national association that represents and serves its members and the field of geriatric psychiatry. These 75 papers are critically appraised by the members of AAGP using a standardized format and a summary of these papers and their practical application is provided by these experts. This information can be used by anyone who wants to learn about the field of geriatric psychiatry.Table of ContentsSection 1: Adverse effects of medications.- Do atypical antipsychotics cause stroke?.- Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials.- Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons.- The efficacy and safety of atypical antipsychotics for the treatment of dementia: a meta-analysis of randomized placebo-controlled trials.- Do antipsychotics lead to cognitive impairment in dementia? A meta-analysis of randomised placebo-controlled trials.- A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias.- Section 2: Anxiety Disorders.- Treatment of panic disorder in older adults: a pilot study comparison of alprazolam, imipramine, and placebo.- Efficacy and tolerability of citalopram in the treatment of late-life anxiety disorders: results from an 8-week randomized, placebo-controlled trial.- Efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder: a pooled analysis of four randomized, double-blind, placebo-controlled studies.- Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial.- Meta-analysis Comparing Different Behavioral Treatments for Late-Life Anxiety.- Cognitive Behavior Therapy for Generalized Anxiety Disorder Among Older Adults in Primary Care: A Randomized Clinical Trial.- Stepped-care prevention of anxiety and depression in late life: a randomized controlled trial.- A randomized controlled study of paroxetine and cognitive-behavioural therapy for late-life panic disorder.- Antidepressant medication augmented with cognitive-behavioral therapy for generalized anxiety disorder in older adults.- A meta-analysis of cognitive functioning in older adults with PTSD.- Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis.- Section 3: Bipolar Disorder.- A Pilot Study of Standardized Treatment in Geriatric Bipolar Disorder.- Differences in clinical features and mental health service use in bipolar disorder across the lifespan.- Effect of antidepressant use on admissions to hospital among elderly bipolar patients.- GERI-BD: A Randomized Double-Blind Controlled Trial of Lithium and Divalproex in the Treatment of Mania in Older Patients With Bipolar Disorder.- History of Bipolar disorder and the risk of dementia: A systematic review and meta-analysis.- Section 4. Delirium.- A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients.- Delirium in elderly patients and the risk of post discharge mortality, institutionalization, and dementia: a meta-analysis.- Effectiveness of multicomponent nonpharmacological delirium interventions: a meta-analysis.- Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis.- Interventions for preventing delirium in older people in institutional long‐term care.- Section 5: Depressive Disorders.- Nortriptyline and Interpersonal Psychotherapy as Maintenance Therapies for Recurrent Major Depression. A Randomized Controlled Trial in Patients Older Than 59 Years.- Continuation treatment of delusional depression in older adults.- Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial.- Remission in Depressed Geriatric Primary Care Patients: A Report from the PROSPECT Study.- Executive dysfunction and the course of geriatric depression.- Maintenance Treatment of Major Depression in Old Age.- Placebo-Controlled Study of Relapse Prevention With Risperidone Augmentation in Older Patients with Resistant Depression.- Efficacy of Second-Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence.- A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD).- Speed of remission in elderly patients with depression: electroconvulsive therapy v. medication.- A systematic review and meta-analysis of psychotherapy for late-life depression.- A novel strategy for continuation ECT in geriatric depression: phase 2 of the PRIDE Study.- Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.- Improvement in Depression is Associated with Improvement in Cognition in Late-Life Psychotic Depression.- Section 6: Electroconvulsive Therapy.- Continuation/Maintenance Treatment with Nortriptyline Versus Combined Nortriptyline and ECT in Late-Life Psychotic Depression: A Two-Year Randomized Study.- Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia.- Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study.- Electroconvulsive Therapy and Risk of Dementia-A Nationwide Cohort Study in Taiwan.- Section 7: Grief.- Treatment of complicated grief in elderly persons: a randomized clinical trial.- Section 8: Pain Disorders.- Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-Analysis.- Section 9: Psychotic Disorders.- A Randomized, Controlled Trial of Cognitive Behavioral Social Skills Training for Middle-Aged and Older Outpatients with Chronic Schizophrenia.- Safety and tolerability of oral paliperidone extended-release tablets in elderly patients with schizophrenia: a double-blind, placebo-controlled study with six-month open-label extension.- Antipsychotic treatment for elderly people with late-onset schizophrenia.- Schizophrenia and risk of dementia: A meta-analysis study.- Antipsychotic treatment of very late-onset schizophrenia-like psychosis (ATLAS): a randomised, controlled, double-blind trial.- Section 10: Neurocognitive Disorders.- Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis.- Depression and risk for Alzheimer disease: Systematic review, Meta-analysis, and Metaregression analysis.- Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease.- Predictors of progression from mild cognitive impairment to Alzheimer disease.- Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis.- Personality and risk of Alzheimer’s disease: New data and meta-analysis.- Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis.- Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis.- Meta-analysis of modifiable risk factors for Alzheimer’s disease.- Memantine for Alzheimer's Disease: An Updated Systematic Review and Meta-analysis.- Update on the Risk of Motor Vehicle Collision or Driving Impairment with Dementia: A Collaborative International Systematic Review and Meta-Analysis.- Pharmacological interventions for apathy in Alzheimer's disease.- Section 11: Sleep Disorders.- Behavioral and Pharmacological Therapies for Late-Life Insomnia: A Randomized Controlled Trial.- Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial.- Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials.- Cognitive behavior therapy for older adults with insomnia and depression: a randomized controlled trial in community mental health services.- Section 12: Suicides.- Medical Illness and the Risk of Suicide in the Elderly.- The Risk of Suicide with Selective Serotonin Reuptake Inhibitors in the Elderly.- Section 13: Substance Use Disorders.- Naltrexone as an Adjunctive Treatment for Older Patients with Alcohol Dependence.- Older adult patients with both Psychiatric and Substance abuse disorders: Prevalence and Health service use.- Five-year alcohol and drug treatment outcomes of older adults versus middle-aged and younger adults in a managed care program.- Treatment of Late-Life Depression Complicated by Alcohol Dependence.- Screening and Brief Intervention for Substance Misuse Among Older Adults: The Florida BRITE Project.

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Book SynopsisThis book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.Table of ContentsSee attachments

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Book SynopsisExtracorporeal photopheresis (ECP) is the first FDA approved cellular photoimmunotherapy for cancer, namely cutaneous T-cell lymphoma, and has demonstrated efficacy in various diseases that have a suspected involvement of pathogenic T-cells including prevention and treatment of acute and chronic graft-versus-host disease, organ transplant rejection, selected autoimmune diseases and Sezary syndrome. In ECP, patient’s blood mononuclear cells are collected, exposed to ultraviolet light in the presence of extracorporeally administered liquid 8-methoxypsoralen and reinfused. Besides its considerable efficacy ECP has an exceptional safety profile, does not cause general immunosuppression and thus, does not increase risk of infectious complications and relapse of malignant disease. Exciting preclinical data and clinical observations provide insight into the mechanisms of action of ECP and support its immunomodulatory role. This book will provide an overview on the historical development of ECP, technical aspects for its use in various patient populations including children and adults, novel research findings both in preclinical models and in various patient cohorts and will stimulate further research in organ, tissue and cell transplantation and autoimmune disorders.

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Book SynopsisDevelop your skills and confidence with expert tips for treating back pain For any therapist who has been challenged by a client complaining of pain or stiffness in the neck or back, The Big Back Book: Tips & Tricks for Therapists is packed with ideas and suggestions for the assessment, treatment, and aftercare of the spine. The author shares tips gathered from many years of experience as a physical therapist and massage therapist, providing step-by-step guidance on everything from testing range of motion and documenting findings, to locating specific muscles and vertebrae, to identifying the source of pain and managing posture and muscle tone issues. With a clear and conversational writing style and easy-to-follow organization of chapters, this book allows readers to gain valuable insights and immediately apply techniques into practice. Highlights: Organizes material by sections on cervical spine, thoracic spine, and lumbar spine with each section following a consistent format to aid in quick reference of needed information Presents commonly asked questions, answered by the author, throughout the text Offers helpful hints for encouraging client self-care Includes useful tables, forms, checklists, and questionnaires to optimize treatment outcomes Clarifies methods and concepts with more than 900 simple line drawings The wealth of practical advice and information contained within makes The Big Back Book: Tips & Tricks for Therapists a must-have volume for massage therapists, physical therapists, and osteopaths with clients seeking relief from neck and back pain. Practitioners and students alike will enhance their knowledge and expand their repertoire of assessment and treatment techniques.Table of ContentsSection I: Cervical Spine Chapter 1: Neck Assessment Chapter 2: Neck Treatment Chapter 3: Neck Aftercare Section II: Thoracic Spine Chapter 4: Thoracic Assessment Chapter 5: Thoracic Treatment Chapter 6: Thoracic Aftercare Section III: Lumbar Spine Chapter 7: Lumbar Assessment Chapter 8: Lumbar Treatment Chapter 9: Lumbar Aftercare

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Book SynopsisThe present book covers the basic principles of cardiovascular physiology, pathophysiology and advanced pharmacology with particular emphasis on cellular mechanisms of drug action. It provides an update on the progress made in several aspects of cardiovascular diseases so that it might kindle scientists and clinicians alike in furthering basic and translational research. In addition, the book is expected to fill imperative gaps in understanding and optimally treating cardiovascular disease. Trade Review“The editors, who are experienced pharmacologists … have provided a comprehensive coverage of pharmacotherapy of heart diseases backed by a review of the pathophysiologic basis of the disease and therapy. … would be of immense value for physicians treating heart disease and allied professionals in pharmaceutical and biomedical backgrounds who have an interest in cardiology. … this book will prove a valuable resource as recent advances are covered well by experts in the respective fields.” (Raja J. Selvaraj, Journal of Pharmacology and Pharmacotherapeutic, Vol. 7, 2016)“The book is an extensive ‘link’ between ‘How’ cardiovascular system works at molecular and signaling pathway levels … . Overall, it is a fantastic attempt to demystify cardiovascular diseases at cellular and molecular levels and utilize the knowledge to potentially change the way cardiology is practiced and learned. … it is a book worth a read for those involved in cardiovascular research … .” (Kamal H. Sharma, Indian Journal of Pharmacology, Vol. 47 (6), December, 2015)Table of ContentsHeart Failure.- Cardiac Hypertrophy.- Cardiac Arrhythmias.- Valvular Heart Disease.- Coronary Heart Disease.- Management of Pericarditis.- Hypertension.- Atherosclerosis and hyperlipidemia.- Cardiovascular Conditions of Childhood.- Sudden Cardiac Death.- Peripheral artery disease.

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Book SynopsisThis book provides a comprehensive overview of the clinical phenomenon of pica. It focuses specifically on the disorder as it presents in children, adolescents, and adults with autism spectrum disorder (ASD) and intellectual disabilities (ID). Initial chapters introduce current theories and definitions, followed by a more detailed examination of how developmental disabilities complicate diagnosis and intervention. The volume describes evidence-based and clinically sound approaches to the treatment and prevention of pica in school and adult clinical settings, ranging from behavioral treatment to function-based interventions. In addition, it discusses common diagnostic, client, and provider issues that result in pica remaining undetected among individuals with ASD and ID.Featured topics include: Definition of pica in accessible terms, differentiating between various forms of the disorder. Issues and practical methods of prevention and treatment of pica in developmentally disabled persons. Functional and behavioral assessment methods for pica in individuals with ASD and ID. A range of effective behavioral and nonbehavioral treatments for pica. Illustrative cases and service delivery challenges. Areas for future research and practice. Pica in Individuals with Developmental Disabilities is an invaluable resource for researchers, clinicians and other professionals, and graduate students in clinical child and school psychology, behavior analysis/therapy, and social work as well as child and adolescent psychiatry, pediatrics, family studies, and special education.Table of ContentsPart I: Foundational Issues.- Chapter 1. Definition and Diagnosis.- Chapter 2. Epidemiology.- Chapter 3. Theories.- Part II: Treatment.- Chapter 4. Behavioral Assessment and Treatment: An Overview.- Chapter 5. Functional Assessment and Analysis and Function-Based Interventions.- Chapter 6. Behavioral Interventions: Non-Function Based Interventions.- Chapter 7. Behavioral Interventions: Treatment Programs and Outcome Data.- Chapter 8. Prevention Treatment and Clinical Management of Pica.- Chapter 9. Biomedical and Other Interventions.- Part III: Emerging Issues.- Chapter 10. Future Directions for Research and Services.

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Book SynopsisThis book is a practical, up-to-date guide to the correct use of lithium for the short- and long-term treatment of mood disorders. Among the subjects addressed are the pharmacology and mechanisms of action of lithium, its use for maintenance treatment, the role of lithium in the treatment of mania and depression and in suicide prevention, further clinical indications, the administration of lithium during pregnancy and the postpartum period, and adverse effects and their management. Relevant background information is provided on the diagnosis, classification, and natural course of mood disorders, and an overview of other treatments for bipolar disorder and major depression is included. Lithium is the essential medication for patients with mood disorders. The evidence of its efficacy in maintenance treatment is acknowledged in all major international treatment guidelines for bipolar disorders and, when used correctly, lithium unquestionably produces the most dramatic benefits of any medication in psychopharmacology. This essential guide is written by two international experts in the treatment of mood disorders who have more than 25 years of experience in the use of lithium and have authored numerous scientific articles on lithium. Table of ContentsDiagnosis and classification of mood disorders.- Natural course of mood disorders and its treatment.- History of lithium treatment.- Pharmacology and mechanisms of action.- Maintenance treatment with lithium.- Treatment of mania with lithium.- Treatment of depression with lithium.- Suicide prevention with lithium.- Other clinical indications of lithium including neuroprotective effects and its potential indications.- Lithium in pregnancy and postpartum period.- Practical management of lithium.- Adverse effects and its management.- Other treatments for bipolar disorder and major depression.

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Book SynopsisOxygen therapy is a treatment that provides a patient with extra oxygen to breathe in. It is also called supplemental oxygen. It is only available through a prescription from a health care provider. Patients may receive it in hospital, another medical setting, or at home. Some people only need it for a short period of time. Others will need long-term oxygen therapy. There are different types of devices that can provide oxygen. Some use tanks of liquid or gas oxygen. Others use an oxygen concentrator, which pulls oxygen out of the air. The oxygen is administered through a nose tube (cannula), a mask, or a tent. The extra oxygen is breathed in along with normal air. This book is a concise guide to oxygen therapy for clinicians and trainees. Divided into four sections the text begins with an overview of the basic facts of oxygen, describing the different types and their individual uses in clinical therapy. Section two discusses the physiology and monitoring of oxygen therapy, and section three covers different devices and delivery systems, and oxygen toxicity (lung damage from breathing in too much extra oxygen). The final section examines oxygen targets in disease specifics, how the therapy works, and the effects of hypoxia (low oxygen levels in body tissues) and hypoxemia (low oxygen levels in the blood).Table of ContentsSection 1: Basic Facts of Oxygen Industrial Oxygen/Medical Oxygen Medical Piped Gas Structure Design and Safety Systems/Pin Index Safety Medical Compressed Gas Cylinders/Handling and Use Cryogenic Liquid Medical Oxygen Oxygen Concentrators/Augmentors Oxygen Hazards and Safety Audit of Oxygen Usage in Prehospital and Hospital Settings Section 2: Physiology & Monitoring of Oxygen Therapy Physiology of Gas Exchange Goals of Oxygen Therapy Drive to Breathe and Carbon Dioxide Retention Oxygen Transport Oxhemoglobin Dissociation Curve Diffusion of Oxygen and Factors Affecting Gas Exchange Pulse Oximetry - Understanding and Limitations Venous and Arterial Blood Gas Analysis Section 3: Oxygen Delivery Systems for the Individual Patients Oxygen Delivery Devices Humidification High Flow Oxygen Therapy Hyperbaric Oxygen Therapy Oxygen Toxicity Section 4:Oxygen Targets The Effects of Hypoxia & Hypoxemia How Does Oxygen Therapy Work? O2 Therapy and Targets in Disease Specifics

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Book SynopsisThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.Table of Contents1. Basic Pharmacokinetic Principles.- 2. Antibiotic Pharmacodynamics.- 3. Physiological Manifestations of Critical Illness.- 4. Dosing in Obese Critically Ill Patients.- 5. Hypoalbuminemia and Altered Protein Binding.- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill.- 7. Augmented Renal Clearance.- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation.- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity.- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill.- 11. Antifungal PK/PD in the Critically Ill.- 12. Antibiotic Dosing in Pediatric Critically Ill Patients.- 13. Antibiotic Stewardship in the Intensive Care Unit.

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Book SynopsisThe book contains review articles providing a comprehensive overview of cannabis/marijuana’s diverse healing aspects in human healthcare (medicinal, nutraceutical, skincare, etc.). The research articles include the role of cannabis in cancer treatment, drug discovery, cosmeceutical potential, prophylactic and therapeutic use for treating neuropathic pain and migraine, pharmacokinetics, safety profile, and issues related to the consumption of cannabis/marijuana. Another salient feature of the book is a complete mapping and region- and sector-wise critical analysis of cannabis/marijuana patents on healthcare and future directions for the benefit of researchers and businesses/entrepreneurs interested in the rapidly advancing area of cannabis. The text describes cannabis/marijuana’s detailed legal aspects, production prospects, and applications for healthcare and recreational purposes in the USA. It traces the traditional roots of cannabis use in Turkey, Israel, the Middle East, Africa, and India. This unique compendium of articles will be useful as a reference book for students, researchers, academics, business houses, and all individuals interested in medicinal, nutraceutical, cosmeceutical, traditional, legal, and commercial aspects of cannabis usage.Table of ContentsChapter 1. A Complete Patent Analysis of Cannabis/Marijuana in Drug Delivery and Disease Conditions.- Chapter 2. Neuropharmacological Approaches to Modulate Cannabinoid Neurotransmission.- Chapter 3. Cannabinoids in Cancer: Cross-talk Between Cannabinoids and miRNAs.- Chapter 4. Cannabis As A Potent Therapeutic Agent For Pharmaceutical Drugs: Recent Advancement In Drug Discovery And Human Healthcare.- Chapter 5. Cannabinoid-Based Innovative Prophylactic and Therapeutic Interventions for Neuropathic Pain and Migraine.- Chapter 6. The Legality of Use and Consumption of Cannabis (Marijuana) in the United States of America.- Chapter 7. Cannabis in Healthcare: Ethnobotanical and Pharmaceutical Perspectives and Legal Status in Turkey and The Middle East.- Chapter 8. Understanding the Pharmacokinetics, Safety Profile, and Scope of the Concerned Issue to Evade the Consumption of Cannabis/Marijuana.- Chapter 9. Traditional Uses of Cannabis in The Middle East and The Pathway to Cannabis-Based Healthcare in Israel.- Chapter 10. Traditional and Modern Health Uses of Cannabis sativa L. in Africa and its Phytochemical and Pharmacological Profile.- Chapter 11. Traditional Claims on Cannabis: An Indian and Global Scenario.- Chapter 12. Cannabis (Bhanga) in Classical Text of Ayurveda: An Evidence-Based Rationale.- Chapter 13. Cannabis-Based Cosmetic Products and Their Uses.- Chapter 14. Cannabis as A Unique and Valuable Nutraceutical Formulation for the Current and Future Global Wellbeing.- Chapter 15. Traditional, Cultural, and Nutraceutical Aspects of Cannabis in India.

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Book Synopsis​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.Table of ContentsChapter 1_Repurposing of drugs: Introduction to technologies and application. - Chapter 2_The value added medicine: Pharmacovigilance re-evaluated. - Chapter 3_Polypharmacology and drug repurposing. -Chapter 4_Comparative transcriptome analysis for infectious diseases towards the identification of cellular pathways for drug repositioning. -Chapter 5_Repurposing of drugs for the treatment of microbial diseases. -Chapter 6_RNA-dependent RNA polymerase (RdRp) - a potential therapeutic approach for Coronavirus drug repositioning. -Chapter 7_Drug repurposing for emerging and re-emerging infectious diseases. -Chapter 8_Drug repurposing for the control of COVID-19.-Chapter 9_Repurposing of anti-inflammatory agents in the potential treatment of SARS 2CoV -2 infection. -Chapter 10_Repurposing of immune-modulators for the treatment of cancer with a QSAR approach. -Chapter 11_ Repurposing Cancer drugs towards antiviral targets in developing countries. -Chapter 12_Repurposed drugs for hematological malignancies. -Chapter 13_Reverse translational approach in repurposing of drugs for anticancer therapy. -Chapter 14_Repurposing of Minocycline: a tetracycline antibiotic for neurodegenerative disorders. -Chapter 15_Drug repurposing for Neglected diseases: Approaches, challenges and promising candidates. ​

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Book SynopsisThis timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g., diabetes, cancer, inflammation) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. From this concise book, readers will gain an insight into the basics of nanoparticle preparation and find a more detailed account of what is therapeutically feasible by using nanoparticle approaches.Trade Review"This book provides state-of-the-art research material in the area of nanotherapeutics. Its content is clear and didactic and reflects modern knowledge and thinking in pharmaceutics. It is a precious book for all types of readers, including students, research scientists, pharmacists from the industry and practitioners from hospitals who want to expand their knowledge about nanomedicine."—Prof. Jean-Pierre Benoit, University of Angers, FranceTable of ContentsGeneral Aspects in Nanoparticulate Drug Delivery: NanoparticlesTransport Phenomena on Biological BarriersDrug Targeting ApproachesGene TherapyTherapeutic Approaches for Various Diseases: CancerImmunologic ApproachesInflammatory DiseasesDiabetesBrain DiseasesSkin DiseasesAntibioticsParasitologyVaccination

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Book Synopsis.- Chapter 1: Nutritional Analysis on Wild Edible Fruits of Kolli Hills (Eastern Ghats of Tamil Nadu), India.- Chapter 2: Nutraceutical potential of edible plants for balancing dietary requirements in human diet: a case study .- Chapter 3: Exploring the medicinal potential of Muntingia calabura Linn. fruit: A comprehensive overview.- Chapter 4: Wild edible fruits of Western Ghats: A Rich Source of Bioactive Compounds with Health-Promoting Effects - A review.- Chapter 5: Study on Anti-oxidant Activity of Unripe Fruits of Syzygium calophyllifolium using In-vitro Models.- Chapter 6: An Insight to intensify the potential prospects of underutilized wild species of Piper.- Chapter 7: Unveiling the Anti-inflammatory properties of Ficus Fruits: A Promising Frontier for Potential Therapeutic Benefits.- Chapter 8: Potential Prospects of Underexploited Wild Edible Fruits of Tamilnadu.- Chapter 9: Curative potentialities of Garcinia gummi-gutta (L.) Roxb.- a less exploited tropical fruit tree.- Chapter 10:Psidium guajava l. (poor man's fruit) with anti-cancer potential: a comprehensive review.- Chapter 11:An overview on wild edible fruits of Servarayan and Kalrayan hilly ranges.- Chapter 12:A review on Nutritional and Metabolomic analysis of wild edible fruits of Western Ghats of Tamil Nadu, India .- Chapter 13:Improving the microbiological, sensory, and chemical constituents of stored crystallized Jenipapo (Genipa americana L.), a native Brazilian fruit .- Chapter 14_Biomedical applications and Health benefits of wild Noni and its fruits.- Chapter 15_Under-exploited wild edible fruits of Western Ghats A review on antioxidant potential and phytochemistry.- Chapter 16_Edible fruit-yielding wild plants of Tamil Nadu: A preliminary checklist.- Chapter 17_Application of Herbal based edible coating on fruits - A promising technology to counter post-harvest losses.

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