Respiratory medicine Books

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Table of ContentsPostacute Sequelae of COVID-19 Critical Illness COVID-19 and Acute Kidney Injury Role of Acute Thrombosis in Coronavirus Disease 2019 COVID-19 Acute Respiratory Distress Syndrome: One Pathogen, Multiple Phenotypes COVID-19 in the Critically Ill Pregnant Patient Extracorporeal Membrane Oxygenation in COVID-19 Acute Neurologic Complications of COVID-19 and Postacute Sequelae of COVID-19 Severe COVID-19 and Multisystem Inflammatory Syndrome in Children in Children and Adolescents Review of Anti-inflammatory and Antiviral Therapeutics for Hospitalized Patients Infected with Severe Acute Respiratory Syndrome Coronavirus 2 High-Flow Nasal Oxygen and Noninvasive Ventilation for COVID-19 Critical Care Response During the COVID-19 Pandemic

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Book SynopsisWith 39 chapters from international experts in the field, this book covers the current practice in donor and recipient management as well as current treatment strategies and outcomes. It discusses significant advances achieved in the past decade in areas such as donor allocation, organ preservation and management, recipient selection, managementTrade Review"This thorough review of lung transplantation covers in detail all aspects, providing an excellent resource for all health professionals involved in this field. The accompanying ebook can be accessed using different platforms (PC, iPad, Kindle, etc.) and provides tools to easily find chapters, figures, and references… This is one of the most complete resources on lung transplantation and it provides a wealth of information that is easy to access via the online version." - Reinaldo Rampolla, MD(Ochsner Medical Center), Doody's Book Review ServiceTable of ContentsGENERAL TOPICS. History of Lung Transplantation. Immunology of Lung Transplantation. Ethical Considerations in Transplantation: A Focus on Lung Transplantation. Indications for Lung Transplantation and Patient Selection. Recipient Management before Transplantation. DONOR MANAGEMENT. Allocation of Donor Lungs. Donor Selection and Management. Non-Heart-Beating Donors. Donor Lung Preservation. Donor Procurement. Ex Vivo Lung Perfusion. RECIPIENT MANAGEMENT AND OUTCOME. The Humoral Response to Lung Transplantation. Anesthesia for Lung Transplantation. Mechanical Ventilation and Extracorporeal Membrane Oxygenation (ECMO) Bridges to Lung Transplantation. Single-Lung Transplantation: Technical Aspects. Bilateral Sequential Lung Transplantation: Technical Aspects. Heart-Lung Transplantation: Technical Aspects. Lobar Lung Transplantation from Living Donors: Technical Aspects. Technical Aspects of Redo Lung Transplantation and Lung Transplantation after Previous Thoracotomy. Lung Transplantation for Idiopathic Pulmonary Fibrosis. Lung Transplantation for Emphysema and α1-antitrypsin Deficiency. Lung Transplantation for Cystic Fibrosis and Bronchiectasis. Lung Transplantation for Pulmonary Hypertension. Lung Transplantation for Connective Tissue Disorders. Posttransplantation Critical Care Management. Primary Graft Dysfunction. Management of Surgical Complications. Immunosuppression Strategies in Lung Transplantation. Viral Infections in Lung Transplantation. Fungal Infections in Lung Transplantation. Bacterial Infections after Lung Transplantation. Diagnosis of Lung Rejection and Infection: A Pathologist’s Perspective. Obliterative Bronchiolitis/Bronchiolitis Obliterans Syndrome: Etiology, Diagnosis, and Management. Chronic Lung Allograft Dysfunction Other Than Bronchiolitis Obliterans Syndrome. Medical Complications of Lung Transplantation. Malignancy Following Lung Transplantation. Quality of Life Following Lung Transplantation. FUTURE OF LUNG TRANSPLANTATION. Future Therapies in Lung Transplantation. New Horizons in Lung Transplantation.

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Ultrasound is the most reliable, easily available, fast, non-invasive technique to study diaphragm function, and is an irreplaceable tool to diagnose, monitor, and follow -up critical respiratory patients. This essential guide analyses every aspect of ultrasound of the diaphragm and respiratory muscles, a reliable assessment whose function is vital to delivering the most suitable treatment. Ultrasound of the Diaphragm and the Respiratory Muscles also provides insight to diagnosing diaphragmatic dysfunction or paralysis following surgery or neuromuscular diseases, to follow the muscular activity and the time-course of atrophy during mechanical ventilation, and to monitor the weaning phase. It is ideal for professionals and trainees practicing ultrasound in a clinical setting.Key Features Sets the standard for training and competency of this emerging, yet scientifically approved non-invasive technique of ultrasound with all the essential in

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Book SynopsisAn authoritative, accessible guide to how our lungs work and how to protect themTrade Review"Breathing is essential to life, yet historically, the lungs haven’t received as much attention as other organs of the body. Especially as our world faces the intersecting health threats of COVID-19, chronic lung diseases, and air pollution Breathing Lessons is an imperative and engaging read for all those who breathe." -- Harold Wimmer, President and CEO, American Lung Association

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Book SynopsisTrade Review"This book provides an overview of extracorporeal membrane oxygenation (ECMO), released by the Institute for Extracorporeal Life Support." ©Doody's Review Service, 2023, David James Dries, MSE, MD (Regions Hospital) Doody's Score: 4 Stars!Table of ContentsPART I PHYSIOLOGY 1 Oxygen Delivery and Consumption 2 Shock 3 Recognition of Shock 4 Hypoxia 5 The Failure of DO2 - Did What I Do to the Patient Just Work? PART II ECMO FUNDAMENTALS 6 Introduction to ECMO Fundamentals 7 Indications and Selection of Patients for ECMO 8 ECMO Configurations 9 Components, Sensors, and Circuit Access PART III ECMO PHYSIOLOGY 10 Blood Flow Dynamics 11 Membrane Characteristics 12 Veno-Venous ECMO Physiology 13 Veno-Arterial ECMO Physiology 14 Physiology of Retrograde Flow 15 Central Veno-Arterial ECMO Physiology PART IV ECMO MANAGEMENT 16 Introduction to ECMO Management Principles 17 Blood Flow Titration 18 Sweep Gas Flow Titration 19 Ventilator Management on ECMO 20 Anticoagulation and Bleeding Management 21 Pharmacokinetics Index

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Book SynopsisDocuments both environmental and work-related causes of lung disease Unlike other books on the subject, this new volume approaches occupational and environmental lung disease from the starting point of the patient who comes to the physician with respiratory symptoms. The authors recognize that potentially harmful exposures occur not only in the work environment, but also as a result of hobbies or other leisure activities, or from outdoor air pollution, and it is up the physician to identify whether a particular job or hobby is the cause of the patient's respiratory symptoms. To help you arrive at a differential diagnosis, chapters in the book are arranged by job or exposure, and are divided into 5 sections: Personal environment Home environment Other indoor environments Work environment General environment Each is written by an expert in the sTrade Review"Occupational health physicians will find it an invaluable resource for clinical practice." (Occupational Medicine, 11 December 2011) "The editors make good on their promise to provide a very useful clinical reference. This is a helpful companion to have when evaluating these patients.I commend these editors on a very illuminating approach to an important problem." (Doody's, 30 September 2011) "Unlike other books on the subject, this new volume approaches occupational and environmental lung disease from the starting point of the patient who comes to the physician with respiratory symptoms.." (Asiaing.com, 11 November 2010)Table of ContentsContributors. Preface. Introduction (Paul Cullinan and Susan M. Tarlo). Section 1: The personal environment. 1. Cosmetics and Personal Care Products in Lung Diseases (Howard M. Kipen). Section 2: The home environment. 2. Passive Smoking (Maritta S. Jaakkola). 3. Emissions related to cooking and heating (Debbie Jarvis). 4. Cleaning and other household products (Jan-Paul Zock). 5. Building materials and furnishing (Jouni J.K. Jaakkola). 6. Mites, pets, fungi and rare allergens (Frederic de Blay, Magdalena Posa, Gabrielle Pauli, Ashok Purohit). 7. Hobby pursuits (Paul D. Blanc). Section 3: Other indoor environments. 8. Greta Smedje. 9. Secondhand smoke exposure and the health of hospitality workers (Mark D. Eisner). 10. Health Effects of Environmental Exposures while in Automobiles (Madeline A. Dillon and David B. Peden). 11. Indoor Sports (Harman S. Paintal and Ware G. Kuschner). Section 4: Work environment. 12. Agricultural environments and the Food Industry (Jakob Hjort Bønløkke, Yvon Cormier and Torben Sigsgaard). 13. Mining (R. L. Cowie). 14. Metal Industry and related jobs (including welding) (William S. Beckett). 15. Automobile Maintenance, Repair and Refinishing (Meredith Stowe and Carrie A. Redlich). 16. Automotive Industry (Kenneth Rosenman). 17. Wood and textile industries (Kjell Torén, Carrie A. Redlich). 18. The electronics industry (Sherwood Burge). 20. The services industry (George L. Delclos, Lea Ann Tullis and Arch I. Carson). 21. Construction (Gary M. Liss, Edward L. Petsonk and Kenneth D. Linch). 22. Police, firefighters and the military (Aaron Thompson and Stefanos N. Kales). 23. Office Workers and Teachers (Jean M. Cox-Ganser, Ju-Hyeong Park and Kathleen Kreiss). 24. Research workers (Paul Cullinan). 25. Special environments (low altitude). 26. Special environments (high altitude). Section 5: General environment. 27. Natural resources – wildland fires and volcanoes (Sverre Vedal). 28. Traditional urban pollution (Sam Parsia, Amee Patrawalla and William N. Rom). 29. Traffic related urban air pollution (Steven M. Lee and Mark W. Frampton). 30. Outdoor sports (Kai-Håkon Carlsen). Index.

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Book SynopsisThe Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health. Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain. This new Table of ContentsList of contributors, ix Foreword to the second edition, xiv Preface to the second edition, xvi Acknowledgments, xvii PART 1 Influenza: Perspective 1 Human influenza: One health, one world, 3 Daniel B. Jernigan and Nancy J. Cox 2 Influenza pandemics: History and lessons learned, 20 Arnold S. Monto and Robert G. Webster PART 2 Structure and replication 3 Structure, disassembly, assembly, and budding of influenza viruses, 37 Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, Gwendolyn Lee, and Z. Hong Zhou 4 The virus genome and its replication, 57 Robert M. Krug and Ervin Fodor 5 Influenza glycoproteins: Hemagglutinin and neuraminidase, 67 Rupert J. Russell, Steven J. Gamblin, and John J. Skehel 6 Proton channels of influenza A and B viruses, 101 Chunlong Ma, Lawrence H. Pinto, and Robert A. Lamb 7 The NS1 protein: A master regulator of host and viral functions, 114 Robert M. Krug and Adolfo García-Sastre 8 Structure and function of the influenza virus replication machinery and PB1-F2, 133 Andrew Mehle and Jonathan A McCullers 9 The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation, 146 Gabriele Neumann and Yoshihiro Kawaoka 10 Pathogenesis, 157 Hans Dieter Klenk, Wolfgang Garten, and Mikhail Matrosovich PART 3 Evolution and ecology of influenza viruses 11 Ecology and evolution of influenza viruses in wild and domestic birds, 175 Ron A.M. Fouchier and Yi Guan 12 Influenza in swine, 190 Richard Webby and Juergen Richt 13 Equine/Canine/Feline/Seal influenza, 203 Thomas M. Chambers, Edward J. Dubovi, and Ruben O. Donis 14 Emergence and Evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains, 218 Taia T. Wang and Peter Palese PART 4 Epidemiology and surveillance 15 Influenza surveillance and laboratory diagnosis, 231 Maria Zambon 16 Epidemiology of influenza, 250 Marc-Alain Widdowson and Arnold S. Monto PART 5 Immunology of influenza 17 Innate immunity, 269 Akiko Iwasaki and Malik Peiris 18 Antibody-mediated immunity, 283 Nicole Baumgarth,Michael C. Carroll, and Santiago Gonzalez 19 Cell-mediated immunity, 298 Stephen J. Turner, Peter C. Doherty, and Anne Kelso PART 6 Vaccines and vaccine development 20 Immunogenicity, efficacy of inactivated/live virus seasonal and pandemic vaccines, 313 Wendy A. Keitel, Kathleen M. Neuzil, and John Treanor 21 New approaches to vaccination, 327 Chih-Jen Wei, Damian C. Ekiert, Gary J. Nabel, and Ian A. Wilson 22 Control of influenza in animals, 337 Ilaria Capua and Dennis J. Alexander 23 Influenza vaccine production, 352 Klaus Stöhr PART 7 Clinical aspects and antivirals 24 Human influenza: Pathogenesis, clinical features, and management, 373 Frederick G. Hayden and Menno D. de Jong 25 Antivirals: Targets and use, 392 Michael G. Ison and Alan Hay 26 The control of influenza and cost-effectiveness of interventions, 419 Carolyn B. Bridges, Samuel K. Peasah, and Martin I. Meltzer 27 Applications of quantitative modeling to influenza virus transmission dynamics, antigenic and genetic evolution, and molecular structure, 434 Marc Lipsitch and Derek Smith 28 Pandemic preparedness and response, 453 Jonathan S. Nguyen-Van-Tam and Joseph Bresee 29 Influenza: The future, 470 Thomas J. Braciale PART 8 The outbreak of H7N9 30 Appendix, 479 Thomas J. Bracial

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Book SynopsisAn examination of the various tests currently available for the assessment of infant respiratory function, which describes the performance, interpretation and possible refinement of each procedure. The text also reviews essential measurement conditions and equipment requirements.Table of ContentsPartial table of contents: Symbols, Abbreviations, and Units in Infant Pulmonary FunctionTesting (P. Quanjer, et al.). Measurement Conditions (C. Gaultier, et al.). Equipment Requirements for Infant Respiratory Testing (P. Sly &G. Davis). Measurement of Flow and Volume (J. Bates, et al.). Measurements During Tidal Breathing (S. Stick). Respiratory Inductive Plethysmography (J. Adams). Esophageal Manometry (Al. Coates, et al.). Passive Respiratory Mechanics (M. Fletcher, et al.). Measurements of Chest Wall Function (J. Allen & Y.Sivan). Forced Oscillation Technique (K. Desager, et al.). Forced Expiratory Maneuvers (P. Le Souef, et al.). Noninvasive Determination of Blood Gases (C. Poets & R.Martin). Clinical Epidemiology and Future Directions (J. Hanrahan, etal.). Index.

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Book SynopsisWhy does tuberculosis, a disease which is both curable and preventable, continue to produce over 50,000 new cases a year in South Africa, primarily among blacks? In answering this question Randall Packard traces the history of one of the most devastating diseases in twentieth-century Africa, against the background of the changing political and economic forces that have shaped South African society from the end of the nineteenth century to the present. These forces have generated a growing backlog of disease among black workers and their families and at the same time have prevented the development of effective public health measures for controlling it. Packard's rich and nuanced analysis is a significant contribution to the growing body of literature on South Africa's social history as well as to the history of medicine and the political economy of health.

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Book SynopsisThis book has become the standard reference text on respiratory diseases in children. It has been extensively revised and updated to encompass the latest developments, and there are now specific chapters on obstructive sleep apnoea and the lung in HIV infection. The biggest revisions to existing chapters are in those on growth and development, respiratory noises, cough and pulmonary consequences of inhalation. The clinical approach in this book is strongly based on an understanding of epidemiology, pathophysiology and increasingly, molecular biology. This fourth edtition brings a stronger theoretical basis to the clinical practice that has been one of the strengths of previous edtitions.Table of Contents1: Lung Growth and Development;. 2: Neonatal Respiratory Disorders;. 3: Epidemiology of Acute Respiratory Infections;. 4: Clinical Patterns of Acute Respiratory Infection;. 5: Respiratory Noises;. 6: Asthma - Pathogenesis, Pathophysiology and Epidemiology;. 7: Asthma - Clinical Patterns and Management;. 8: Cough;. 9: Suppurative Lung Disease;. 10: Cystic Fibrosis;. 11: Pulmonary Complications of Inhalation;. 12: Tuberculosis in Childhood;. 13: Lung Defences and Infection in the Compromised Host;. 14: The Lung and HIV Infection;. 15: Miscellaneous Lung Diseases;. 16: Obstructive Sleep Apnoea;. 17: Congenital Malformations of the Bronchi, Lungs, Diaphragm and Rib Cage;. 18: Tumours of the Chest Wall, Mediastinum and Lungs;. Appendix;. Index

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Book SynopsisTrade ReviewNow in its fourth edition this text is a must for all physiotherapy students. The chapters are well laid out, and all of the information is explained in an easily understandable way. This new edition provides the most up to date information for clinical practice from paediatrics through to the elderly. Chapter six is particularly useful, it provides the reader with case studies and then works through a logical way of problem solving along with introducing the reader to specific outcome measures. All in all a must have text!!!! - Laura Culpan, Physiotherapy Student, University of Bradford This book is a must have for respiratory learning as it is clear and concise and contains both adults and paediatric care. The clear diagrams make it easier to learn and the chapters cover core subjects for example assessments, techniques, paediatrics, ventilation and many more. Throughout the authors have made small summary physio points which will be useful when revising for a particular topic. The authors have also used flow charts and pictures to put across some of the information which is very useful for visual learners. I would very much recommend this book as it contains all of the information needed for respiratory at university and during your career. - Charlotte Barrett, Physiotherapy Student, Cardiff University, UK. Overall this is a good all-round, evidence based resource to use whilst studying or if newly qualified that covers all the main aspects of respiratory and cardiac physiotherapy. It is a great place to start when writing case studies in this field. This book is structured in the familiar style that we have come to know Elsevier for: a logical and clear design that is well laid out with the text presented in a variety of formats and supported with photographs, drawings and diagrams. The sections covering surgery, again provide good information for the student, particularly things like commonly used drugs and side effects, terminology and common procedures that are likely to be encountered. Finally, there are a number of handy images stored online that can be used in your presentations but perhaps this facility would have been better with a few more resources available, such as quizzes or tests to assess knowledge. - Linda Wilkinson, Physiotherapy Student, University of Southampton, UK. As a 1st year physiotherapy student, I've been able to use this book to understand the pathophysiology of cardiorespiratory problems as well as their clinical management. It's also well structured, beginning with the assessment of a cardiorespiratory patient and covering assessment tests and techniques and their interpretation. I also like that it has separate sections for paediatrics and adults and also has a good overview of types of surgery. I feel that this book is not only useful to me now but will be essential when I go on placement, as a reference to clarify and build on my day-to-day learning. I would recommend this text to anyone looking for a good overall cardiorespiratory text. - Mayuri Butchart, Physiotherapy Student, King's College London, UK. "I found this text book useful, informative and a great aid to my first practice placement." Ms N.L Benson, 2nd Year Physiotherapy Student, University of Central LancashireTable of ContentsForeword About The Editors Preface Acknowledgements Contributors 1 ANATOMY AND PHYSIOLOGY OF THE RESPIRATORY SYSTEM Mandy Jones, Alex Harvey, Eleanor Main 2 CLINICAL ASSESSMENT Adults Amanda Thomas, Lyndal J Maxwell Infant and Child Eleanor Main The Acutely Ill or Deteriorating Patient Sarah Keilty 3 THORACIC IMAGING Adults Conor D Collins, Susan J Copley Paediatrics Joy L Barber, Christopher D George 4 CARDIAC AND CARDIOVASCULAR DISEASES Andrew D Hirschhorn, Sean F Mungovan, David A B Richards 5 RESPIRATORY DISEASES Anne E Holland, Jennifer A Alison With a contribution from Alex Harvey and Mandy Jones 6 OUTCOME MEASUREMENT IN CARDIORESPIRATORY PHYSIOTHERAPY PRACTICE Selina M Parry, Linda Denehy With Contributions from Claire E Baldwin, Bronwen Connolly, Elizabeth H Skinner, Sally J Singh, Sarah Rand, Craig A Williams 7 PHYSIOTHERAPY INTERVENTIONS Eleanor Main With contributions from Sue Berney, Linda Denehy, Michelle Chatwin, Mark R Elkins, Daniel Flunt, Amanda J Piper, Annemarie L Lee, Bredge Mccarren, Harriet Shannon, Rosemary Moore, Sarah Rand, Barbara A Webber, Marie T Williams 8 OPTIMIZING ENGAGEMENT AND ADHERENCE WITH THERAPEUTIC INTERVENTIONS Mandy Bryon 9 ADULT INTENSIVE CARE Jennifer Paratz, George Ntoumenopoulos, Alice Y M Jones, Claire Fitzgerald 10 PAEDIATRIC INTENSIVE CARE Paediatric Mechanical Support Stewart Reid, Mark J Peters Physiotherapy Management of Ventilated Infants and Children Eleanor Main, Alicia J Spittle 11 CARDIOTHORACIC SURGERY FOR ADULTS Doa El-Ansary, Julie C Reeve, Sulakshana, Balachandran, Michelle Mulligan, Linda Denehy 12 PHYSICAL ACTIVITY AND REHABILITATION Physical Activity and Physical Fitness in Health and Disease Chris Burtin, Vasileios Andrianopoulos, Martijn A Spruit Pulmonary Rehabilitation Katy Mitchell, Fabio Pitta, Anne E Holland, Annemarie L Lee, Linda Denehy Cardiac Rehabilitation Julie Redfern, Jennifer Jones 13 CARDIORESPIRATORY MANAGEMENT OF SPECIAL POPULATIONS Linda Denehy, Eleanor Main With contributions from Sarah Smailes, Anita Plaza, Jennifer Paratz, Leanne Williams, Claire Bradley, Jacqueline L Luke, Jacqueline Ross, Brooke Wadsworth, Kate J Hayes, Prue E Munro, Paul Aurora, Helena Van Aswegen, Craig A Williams, Sarah Rand, Catherine L Granger, Sue Berney, Amy Nordon-Craft, Linda Denehy APPENDIX - NORMAL VALUES, CONVERSION TABLE AND ABBREVIATIONS Index

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Book SynopsisDisordered breathing patterns may be a symptom or a cause of frequently undiagnosed health problems. This book is intended to help practitioners understand the causes and effects of disordered breathing and to provide strategies and protocols to help restore normal function.Trade Review"...this far-reaching book covers everything one would wish to learn about breathing pattern disorders - I feel it is an essential source of reference and information to all health professionals working in this area...I would urge everyone interested in the subject to place an order..." Anne Pitman MCSP SRP, Manual Therapy, October 2002 "The whole book is well illustrated and referenced, provides practical case examples and sensible cautions..I cannot think of anything they have left out.” Ashley Conway. Journal of Holistic Healthcare: Volume 4 Issue 4 November 2007 Patients with common psychological dysfunction including anxiety, low mood and depression, sleep disorder, chronic low energy syndromes etc., all can respond well when the breath cycle is identified and adapted by cognitive processes. This text is the most comprehensive of its kind and the clinical application of the content so broadly based it deserves a wide readership. Donald Scott, Osteopath, UK This is an extremely well-detailed book and I love how it explores all areas of breathing i.e. the psychological, emotional and physical elements of the process. Eva Au Zveglic, Specialised Respiratory Physiotherapist, UK This book will appeal to anyone with an interest in breathing from whatever discipline they belong to. Anne Pitman, Physiotherapy, Devonshire Place, London, UK As the current title suggests, I feel the book appropriately covers multidisciplinary management strategies of BPD which is an extremely important aim given that the disorder is so complex with multiple aetiologies and no single assessment or treatment tool. Kate Bazin. Physiotherapist, UK Breathing is an overlooked part of human function. We need more information about breathing as it is such an important prerequisite for the normal functioning of so many other body systems. Ken Crenshaw, Head Athletic Trainer of the Arizona Diamondbacks Baseball Team, USA As clinical practitioners we must always be aware of causation, maintaining and exacerbating factors. Abnormal breathing has the ability to be all three of these. T. Hewetson, Lecturer in Osteopathy, Oxford, UK This is not a perfect all-encompassing textbook.That was not its purpose. As a catalyst for stimulating further exploration and for use as a reference in clinical work of wide-ranging paradigms it succeeds admirably. David Propert, British School of Osteopathy, UK, International Journal of Osteopathic Medicine (August 2014) Table of Contents1. What are Breathing Pattern Disorders? - Leon Chaitow, Dinah Bradley, Chris Gilbert 2.1 Dynamic Neuromuscular Stabilization - Developmental Kinesiology: breathing stereotypes and postural-locomotion function - Pavel Kolar, Alena Kobesova, Petra Valouchova, Petr Bitnar 2.2. The structure and function of breathing - Leon Chaitow, Dinah Bradley, Chris Gilbert 2.3. Nasal influences on breathing - Jim Bartley 3. Patterns of breathing dysfunction in hyperventilation and breathing pattern disorders - Dinah Bradley 4. Biochemical aspects of breathing - Chris Gilbert (notes on food sensitivities and nutrition: Leon Chaitow) 5. Interaction of psychological and emotional variables with breathing dysfunction - Chris Gilbert 6.1. Dynamic Neuromuscular Stabilization: Assessment methods - Pavel Kolar, Alena Kobesova, Petra Valouchova, Petr Bitnar 6.2. Osteopathic assessment of structural changes related to BPD - Leon Chaitow 6.3. Physiotherapy Assessment Approaches - Dinah Bradley 6.4 Psychological assessment of breathing problems - Chris Gilbert 6.5 Questionnaires and Manual Methods for Assessing Breathing Dysfunction - Rosalba Courtney, Jan van Dixhoorn 6.6 Capnography Assessment - Laurie McLaughlin 7.1a Indirect approaches to breathing regulation - Jan van Dixhoorn 7.1b Dynamic Neuromuscular Stabilization: Treatment methods - Pavel Kolar, Alena Kobesova, Petra Valouchova, Petr Bitnar 7.2 Osteopathic treatment of thoracic and respiratory dysfunction - Leon Chaitow 7.3 Physiotherapy in rehabilitation of breathing pattern disorders - Dinah Bradley 7.4 Physiotherapy in rehabilitation of breathing pattern disorders - Chris Gilbert 7.5 Speech and singing - Eva au Zveglic 7.6 Breathing Pattern Disorders and the Athlete - Tania Clifton Smith 7.7 Capnography in treatment of BPD - Laurie McLaughlin 8.1 Breathing patterns in longstanding pain disorders: A somatocognitive approach to evaluation and therapy - G. Haugstad, T. Haugstad 8.2 Buteyko breathing method - Rosalba Courtney 8.3 Feldenkrais® and Breathing - John C. Hannon 8.4 Pilates in the rehabilitation of breathing disorders - Warrick McNeill, Suzanne Scott 8.5 Tai chi Qigong and breathing - Aileen Chan 8.6 A review of the use of yoga in breathing disorders - Shirley Telles, Nilkamal Singh 9 Self-help approaches - Leon Chaitow, Dinah Bradley, Chris Gilbert

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Book SynopsisTable of ContentsPart 1 Introduction 1 The radiographic image Part 2 Radiation physics, equipment and radiation protection 2 The production, properties and interactions of X-rays 3 Dental X-ray generating equipment 4 Image receptors 5 Imaging processing 6 Radiation dose, dosimetry and dose limitation 7 The biological effects associated with X-rays, risk and practical radiation protection Part 3 Radiography 8 Dental radiography - general patient considerations including control of infection 9 Periapical radiography 10 Bitewing radiography 11 Occlusal radiography 12 Oblique lateral radiography 13 Skull and maxillofacial radiography 14 Cephalometric radiography 15 Tomography and panoramic radiography 16 Cone beam computed tomography (CBCT) 17 The quality of radiographic images and quality assurance 18 Alternative and specialized imaging modalities Part 4 Radiology 19 Introduction to radiological interpretation 20 Dental caries and the assessment of restorations 21 The periapical tissues 22 The periodontal tissues and periodontal disease 23 Implant assessment 24 Developmental abnormalities 25 Radiological differential diagnosis - describing a lesion 26 Differential diagnosis of radiolucent lesions of the jaws 27 Differential diagnosis of lesions of variable radiopacity in the jaws 28 Bone diseases of radiological importance 29 Trauma to the teeth and facial skeleton 30 The temporomandibular joint 31 The maxillary antra 32 The salivary glands Bibliography and suggested reading Index

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Book SynopsisTable of ContentsHow to look at a chest X-ray Localizing lesions The CT scan The white lung field The black lung field The abnormal hilum The abnormal heart shadow The widened mediastinum Abnormal ribs Abnormal soft tissues The sick patient The hidden abnormality The chest x-ray quiz

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Book SynopsisFocusing on patients' experiences and the programmes set up to deal with the tuberculosis epidemic experienced by the Inuit in the mid-20th century, this study is based on recollections of patients and interviews with participants in the government programmes.

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Book SynopsisThe Second Edition of Pulmonary Physiology and Pathophysiology presents normal and abnormal pulmonary function in the same case-based format that has made the first edition a favorite among students. Each chapter begins with a clinical case study of diseases typically seen by practitioners. The cases are followed by a discussion and breakdown of the physiology, pathophysiology, anatomy, pharmacology, and pathology for each disease, and a question-and-answer section. This edition has an infectious diseases chapter, updates on asthma pathogenesis and bronchodilators, and user-friendly features such as chapter openers, chapter outlines, key points summary boxes, and board-formatted questions and answers.

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Book SynopsisNow edited by a pulmonologist, this third edition is one of the best written texts for students learning to understand the assessment and treatment of patients with respiratory disease. Each chapter begins with a background of selected disorders, followed by a case study with questions and answers designed to stimulate critical thinking skills.Table of Contents CHAPTER 1 Introduction to Patient Assessment Robert L. Wilkins, PhD, RRT, FAARC Philip M. Gold, MD, MACP, FCCP CHAPTER 2 Introduction to Respiratory Failure Robert L. Wilkins, PhD, RRT, FAARC James R. Dexter, MD, FACP, FCCP CHAPTER 3 Asthma Robert L. Wilkins, PhD, RRT, FAARC Philip M. Gold, MD, MACP, FCCP CHAPTER 4 Chronic Obstructive Pulmonary Disease Robert L. Wilkins, PhD, RRT, FAARC Philip M. Gold, MD, MACP, FCCP CHAPTER 5 Cystic Fibrosis N. Lennard Specht, MD CHAPTER 6 Hemodynamic Monitoring and Shock Robert L. Wilkins, PhD, RRT, FAARC James R. Dexter, MD, FACP, FCCP CHAPTER 7 Pulmonary Thromboembolic Disease James R. Dexter, MD, FACP, FCCP CHAPTER 8 Heart Failure Arthur B. Marshak, MS, RRT, RPFT George H. Hicks, MS, RRT CHAPTER 9 Smoke Inhalation Injury and Burns George H. Hicks, MS, RRT Carl Eckrode, MPH, RRT CHAPTER 10 Near Drowning William F. Galvin, MSEd, RRT, CPFT, FAARC CHAPTER 11 Acute Respiratory Distress Syndrome Robert L. Wilkins, PhD, RRT, FAARC James R. Dexter, MD, FACP, FCCP CHAPTER 12 Chest Trauma George H. Hicks, MS, RRT Carl A. Eckrode, MPH, RRT CHAPTER 13 Postoperative Atelectasis Thomas P. Malinowski, BS, RRT, FAARC CHAPTER 14 Interstitial Lung Disease N. Lennard Specht, MD, FACP CHAPTER 15 Neuromuscular Diseases N. Lennard Specht, MD, FACP Rebekah Bartos, MSN, FNP CHAPTER 16 Bacterial Pneumonia Robert L. Wilkins, PhD, RRT, FAARC James R. Dexter, MD, FACP, FCCP CHAPTER 17 Pneumonia in the Immunocompromised Patient Philip M. Gold, MD, MACP, FCCP N. Lennard Specht, MD, FACP CHAPTER 18 Sleep Disordered Breathing Enrique Gil, MD, FCCP CHAPTER 19 Tuberculosis James R. Dexter, MD, FACP, FCCP Robert L. Wilkins, PhD, RRT, FAARC CHAPTER 20 Lung Cancer Gregory A.B. Cheek, MD, FCCP, MSPH APPENDIX A Normal Laboratory Values APPENDIX B GOLD Standards for Diagnosing and Treating Patients with COPD APPENDIX C Websites Useful for Learning Information About the Diagnosis and Treatment of Lung Disease Index

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Book SynopsisRely on this best-selling laboratory manual to provide the hands-on practice you need to confidently perform the most common to complex respiratory procedures for class and clinical. Step-by-step instructions with detailed diagrams and illustrations seamlessly guide you through every procedure.Table of Contents Laboratory and Clinical Safety Communication and Cultural Diversity in Health Care Infection Control Sterilization and Disinfection Medical Record Patient Assessment: Basic Skills Vital Signs Patient Assessment: Advanced Skills Bedside Assessment of Pulmonary Mechanics Oxygen Supply Systems Oxygen Analysis Oxygen Therapy Administration Humidity Devices Aerosol Generators Cardiopulmonary Pharmacology Review Aerosol and Medication Therapy Hyperinflation Therapy Techniques Bronchial Hygiene: Chest Physiotherapy Adjunct Techniques for Bronchial Hygiene Manual Resuscitators and Manual Ventilation Pharyngeal Airways Suctioning Endotracheal Intubation Tracheostomy Care Artificial Airway Care and Maintenance Noninvasive Blood Gas Monitoring Arterial Blood Gas Sampling Arterial Blood Gas Analysis and Maintenance Blood Gas Interpretation and Calculations Basic Chest X Ray Interpretation Pulmonary Function Testing Electrocardiography Hemodynamic Monitoring Phlebotomy Intravenous Insertion and Maintenance Chest Tube Drainage Systems Bronchoscopy Assisting Noninvasive Ventilation Pressure Ventilators Continuous Mechanical Ventilation Ventilator Modes Ventilator Initiation Patient Ventilator System Care and Maintenance Discontinuation of Mechanical Ventilation Neonatal/Pediatric Respiratory Care Neonatal/Pediatric Ventilation Respiratory Care in Alternate Settings Appendices Normal and Critical Values, Formulas and Rules of Thumb Glossary

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Book SynopsisGain a solid understanding of neonatal and pediatric diseases as you explore real-world patient experiences with this unique resource. In every chapter, unfolding case studies with full-colour illustrations and photographs enhance your critical-thinking skills, making it easy to connect theory with practice.Table of Contents 1. Making Sense of Caring for Kids: A Different Approach to Respiratory Care I. Fetal Development and Transition to Extrauterine Life 2. Fetal Cardiopulmonary Development 3. Resuscitation of the Newborn During Transition to Extrauterine Life II. Perinatal Lung Diseases and Complication 4. Respiratory Distress Syndrome 5. Apnea of Prematurity and Bronchopulmonary Dysplasia 6. Diseases of Full-term infants III. Common Neonatal Complications 7. Pulmonary Complications 8. Multi-system Complications IV. Congenital Anomalies 9. Abdominal Defects 10. Airway abnormalities 11. Acyanotic Heart Defects 12. Cyanotic Heart Defects V. Pediatric Diseases with Respiratory Implications 13. Asthma 14. Cystic Fibrosis 15. Pediatric Pulmonary Diseases 16. Pediatric Infectious Airway Diseases 17. Neuromuscular Disorders 18. Pediatric Accidents with Pulmonary Involvement 19. Pediatric Neurologic Accidents VI. Ethics and Pediatric Palliative Care 20. Ethics in Perinatal and Pediatric Respiratory Care 21. Palliative and End-of-Life Care Glossary Index

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Book SynopsisThis book examines the structure and impact of the SARS epidemic, and its short- and medium-range implications for an interconnected, globalized world. In so doing, it poses a question of the greatest possible significance: Can we learn from SARS before the next pandemic?Trade Review"SARS in China not only makes a significant contribution to China studies but also provides important clues about the state of preparation for global health challenges such as avian flu."—China Review International"This book has lined up a remarkable team of authors to try to answer the question: what can we learn from SARS before the next pandemic? And its value lies in the significant issues that it has highlighted."—The China ReviewTable of ContentsContents Preface vii Contributors xi Introduction: SARS in Social and Historical Context 1 arthur kleinman and james l. watson Part I. The Epidemiological and Public Health Background 1. The Epidemiology of SARS 17 megan murray 2. The Role of the World Health Organization in Combating SARS, Focusing on the Efforts in China 31 alan schnur 3. SARS and China's Health-Care Response: Better to Be Both Red and Expert! 53 joan kaufman Part II. Economic and Political Consequences 4. Is SARS China's Chernobyl or Much Ado About Nothing? 71 tony saich 5. SARS and China's Economy 105 thomas g. rawski 6. SARS in Beijing: The Unraveling of a Cover-Up 122 erik eckholm Part III: Social, Moral, and Psychological Consequences 7. Psychological Responses to SARS in Hong Kong-- Report from the Front Line 133 dominic t. s. lee, m.d., and yung kwok wing, mrcpsych 8. Making Light of the Dark Side: SARS Jokes and Humor in China 148 hong zhang Part IV: Globalization and Cross-Cultural Issues 9. SARS and the Problem of Social Stigma 173 arthur kleinman and sing lee 10. SARS and the Consequences for Globalization 196 james l. watson Notes 205 Index 235

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Book SynopsisThis book examines the structure and impact of the SARS epidemic, and its short- and medium-range implications for an interconnected, globalized world. In so doing, it poses a question of the greatest possible significance: Can we learn from SARS before the next pandemic?Trade Review"SARS in China not only makes a significant contribution to China studies but also provides important clues about the state of preparation for global health challenges such as avian flu."—China Review International"This book has lined up a remarkable team of authors to try to answer the question: what can we learn from SARS before the next pandemic? And its value lies in the significant issues that it has highlighted."—The China ReviewTable of ContentsContents Preface vii Contributors xi Introduction: SARS in Social and Historical Context 1 arthur kleinman and james l. watson Part I. The Epidemiological and Public Health Background 1. The Epidemiology of SARS 17 megan murray 2. The Role of the World Health Organization in Combating SARS, Focusing on the Efforts in China 31 alan schnur 3. SARS and China's Health-Care Response: Better to Be Both Red and Expert! 53 joan kaufman Part II. Economic and Political Consequences 4. Is SARS China's Chernobyl or Much Ado About Nothing? 71 tony saich 5. SARS and China's Economy 105 thomas g. rawski 6. SARS in Beijing: The Unraveling of a Cover-Up 122 erik eckholm Part III: Social, Moral, and Psychological Consequences 7. Psychological Responses to SARS in Hong Kong-- Report from the Front Line 133 dominic t. s. lee, m.d., and yung kwok wing, mrcpsych 8. Making Light of the Dark Side: SARS Jokes and Humor in China 148 hong zhang Part IV: Globalization and Cross-Cultural Issues 9. SARS and the Problem of Social Stigma 173 arthur kleinman and sing lee 10. SARS and the Consequences for Globalization 196 james l. watson Notes 205 Index 235

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Book SynopsisTrade Review"In this defining ethnography of China's public health system and its complex relation to epidemics, Katherine Mason brilliantly describes health professionals, their struggles to be effective and ethical, the barriers they face, and how they animate the Chinese public health system as a lived reality. Infectious Change is an impressive contribution to both China studies and to medical anthropology!" -- Arthur Kleinman, Director * Harvard Asia Center *"Meticulously crafted, Infectious Change draws readers into the world of Chinese public health after SARS. Mason documents fundamentally different approaches to epidemic control among global, state, and local practitioners, including management of migratory populations, data collection, and ethics, arguing that global directives often stymie local efforts. This book elucidates why epidemic prevention everywhere must draw on local knowledge and practices." -- Margaret Lock * author of The Alzheimer Conundrum *"Infectious Change brings us for the first time before a hitherto unacknowledged consequence of the 2009 H1N1 crisis, and, at that, in one of the most epidemiologically critical regions of the globe today. It is this invaluable insight that should hold the attention not only of medical anthropologists but also of the wider global health community." -- Christos Lynteris * Medical Anthropology Quarterly *"This is an excellent, thought-provoking book, which will appeal to those with interests in contemporary China, medical anthropology, and histories of health and disease. It yields insights that will illuminate broader debates, such as those that pivot on the challenges inherent in promoting the "global" as a category in health." -- Robert Peckham * Bulletin of the History of Medicine *"Katherine Mason's book is an important contribution to the fields of Chinese studies and anthropology, joining a recent spate of excellent studies using the methods of anthropology to look at the intersections of public health, cultural practices and politics in China...Mason's book reminds us that implementing public health policy is never only about what is technically correct. It is about the cultural values and practices that govern relationships. It is also about understanding the power dynamics of the political system and generating the political will to construct an enabling environment and accountability mechanism to achieve it. In China, the tensions between centre and local are rarely resolved in favour of local and when new criteria for professional advancement are introduced, it results in the type of dysfunction so masterfully described by Mason." -- Joan Kaufman * China Quarterly *"In Infectious Change, Katherine A. Mason provides a captivating analysis of public health in China in the wake of SARS...Infectious Change is an insightful work that would be of interest to scholars of China and global health practitioners while also being accessible to a general academic reader. For China scholars, Mason makes a major contribution to the literature on public health." -- Emilio Dirlikov * Anthropological Quarterly *"Infectious Change presents a rich ethnographic account of how the Tianmai CDC works, how it would like to transform itself, and the barriers to doing so. It will make an excellent addition to courses on the anthropology of China or of global health because of the clarity of its ethnographic account and also because of the questions it opens up."––Elanah Uretsky, Asian MedicinTable of ContentsContents and Abstracts1Introduction chapter abstractThis chapter situates the reader in time and space and lays out the main arguments of the book. The author provides an overview of the recent history of public health in China, and describes the pseudonymous city of Tianmai. The author then suggests that due to key differences between professional responsibility as it is defined in the clinical and public health settings - particularly with regards to the aggregate nature of the public health "client" – a bifurcation of service and governance arose in Tianmai between a "common" being served and local populations being governed. The chapter lays out five "commons" that will be examined in the rest of the book: a civilized immigrant common, a professional common, a transnational scientific common, a global health common, and a global common. It also suggests that the Tianmai case can offer novel insights into the study of global health. 2City of Immigrants chapter abstractThis chapter takes a closer look at the immigrant city of Tianmai, and considers how the modern, cosmopolitan urban paradise that Tianmai's elites were trying to build included some and excluded others. In particular, the chapter examines the relationship – or lack thereof – between Tianmai's public health professionals and the city's enormous "floating population" of rural-to-urban migrants. The author shows how her interlocutors – former migrants themselves – refused to engage with migrant individuals, and actively maintained personal, moral, and professional boundaries between themselves and the floating population. This effectively divulged public health professionals of responsibility for the majority of the people who lived in their city and established them as "biological non-citizens" who had to be governed but could not be served. In doing this public health professionals worked to serve a civilized immigrant common of modern urban subjects that did not include the floating population. 3Relationships, Trust, and Truths chapter abstractThis chapter illustrates how the power to implement any given public health initiative in China was located within the webs of guanxi, or personal relationships, that public health professionals spun anew at the beginning of each project. Drawing on rich ethnographic description, the chapter takes the reader into the banqueting and other entertainment rituals that public health professionals engaged in almost daily in order to create and maintain these networks of reciprocal obligation and personalistic trust. The author then examines how a group of young, highly educated post-SARS reformers attempted to rid the public health system of guanxi, which they regarded as anti-scientific and akin to corruption. These reformers hoped to build a more transparent and reliable system of disease reporting and governance by establishing a professional common grounded in professionalized trust. 4Scientific Imaginaries chapter abstractThis chapter critically examines public health research and science in Tianmai. The author explores the efforts of Chinese public health professionals to advance their careers through scientific research, and discusses how in the wake of SARS, Chinese public health institutions dramatically increased their investments in scientific research – rendering publishable research a major focus of local public health work. Newly hired young people labored to produce the "quality" and "true" data that they associated with good science. They hoped that doing so would give them a chance to "develop themselves" as members of transnational scientific common, and to escape a local moral world that they felt was dominated by mimicry, deception, and instability. The chapter suggests that their approach to research provides a mirror through which public health researchers in other contexts could critically examine their own ethical practices, raising new questions about global research ethics. 5Pandemic Betrayals chapter abstractThis chapter provides an ethnographically rich eyewitness account of Tianmai's response to the 2009 H1N1 influenza pandemic, describing how public health professionals in Tianmai drew upon the lessons of SARS to mount what they thought would be an internationally lauded response to H1N1. In attempting to prove their pandemic preparedness capabilities and ensure a place among the global scientific elite, however, Tianmai's public health professionals instead found that their full admittance into a global health common and a global common remained elusive. The chapter discusses the professionals' difficulties in escaping their perceived status as a source, rather than a victim, of dangerous viruses; their use of disease control tactics that were portrayed abroad as excessive and unsophisticated; and their disappointment with the failure of their leaders and guanxi partners to act in the professional fashion that they had been trying to promote since SARS. 6Conclusion chapter abstractThe concluding chapter returns to the broader question of what professional responsibility can or should mean in public health and beyond, and asks how public health professionals in China could work to reconcile the "common" with the "population," and population needs with individual needs. The author uses the case of HIV/AIDS to examine the ways in which some public health professionals in Tianmai were experimenting with alternative interpretations of public health that broadened the boundaries of the common to allow in otherwise maligned groups, including rural migrants, gay men, and sex workers. The book ends by considering the implications of this ethnography for the study of public health – both local and global – more broadly.

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Book SynopsisTrade Review"In this defining ethnography of China's public health system and its complex relation to epidemics, Katherine Mason brilliantly describes health professionals, their struggles to be effective and ethical, the barriers they face, and how they animate the Chinese public health system as a lived reality. Infectious Change is an impressive contribution to both China studies and to medical anthropology!" -- Arthur Kleinman, Director * Harvard Asia Center *"Meticulously crafted, Infectious Change draws readers into the world of Chinese public health after SARS. Mason documents fundamentally different approaches to epidemic control among global, state, and local practitioners, including management of migratory populations, data collection, and ethics, arguing that global directives often stymie local efforts. This book elucidates why epidemic prevention everywhere must draw on local knowledge and practices." -- Margaret Lock * author of The Alzheimer Conundrum *"Infectious Change brings us for the first time before a hitherto unacknowledged consequence of the 2009 H1N1 crisis, and, at that, in one of the most epidemiologically critical regions of the globe today. It is this invaluable insight that should hold the attention not only of medical anthropologists but also of the wider global health community." -- Christos Lynteris * Medical Anthropology Quarterly *"This is an excellent, thought-provoking book, which will appeal to those with interests in contemporary China, medical anthropology, and histories of health and disease. It yields insights that will illuminate broader debates, such as those that pivot on the challenges inherent in promoting the "global" as a category in health." -- Robert Peckham * Bulletin of the History of Medicine *"Katherine Mason's book is an important contribution to the fields of Chinese studies and anthropology, joining a recent spate of excellent studies using the methods of anthropology to look at the intersections of public health, cultural practices and politics in China...Mason's book reminds us that implementing public health policy is never only about what is technically correct. It is about the cultural values and practices that govern relationships. It is also about understanding the power dynamics of the political system and generating the political will to construct an enabling environment and accountability mechanism to achieve it. In China, the tensions between centre and local are rarely resolved in favour of local and when new criteria for professional advancement are introduced, it results in the type of dysfunction so masterfully described by Mason." -- Joan Kaufman * China Quarterly *"In Infectious Change, Katherine A. Mason provides a captivating analysis of public health in China in the wake of SARS...Infectious Change is an insightful work that would be of interest to scholars of China and global health practitioners while also being accessible to a general academic reader. For China scholars, Mason makes a major contribution to the literature on public health." -- Emilio Dirlikov * Anthropological Quarterly *"Infectious Change presents a rich ethnographic account of how the Tianmai CDC works, how it would like to transform itself, and the barriers to doing so. It will make an excellent addition to courses on the anthropology of China or of global health because of the clarity of its ethnographic account and also because of the questions it opens up."––Elanah Uretsky, Asian MedicinTable of ContentsContents and Abstracts1Introduction chapter abstractThis chapter situates the reader in time and space and lays out the main arguments of the book. The author provides an overview of the recent history of public health in China, and describes the pseudonymous city of Tianmai. The author then suggests that due to key differences between professional responsibility as it is defined in the clinical and public health settings - particularly with regards to the aggregate nature of the public health "client" – a bifurcation of service and governance arose in Tianmai between a "common" being served and local populations being governed. The chapter lays out five "commons" that will be examined in the rest of the book: a civilized immigrant common, a professional common, a transnational scientific common, a global health common, and a global common. It also suggests that the Tianmai case can offer novel insights into the study of global health. 2City of Immigrants chapter abstractThis chapter takes a closer look at the immigrant city of Tianmai, and considers how the modern, cosmopolitan urban paradise that Tianmai's elites were trying to build included some and excluded others. In particular, the chapter examines the relationship – or lack thereof – between Tianmai's public health professionals and the city's enormous "floating population" of rural-to-urban migrants. The author shows how her interlocutors – former migrants themselves – refused to engage with migrant individuals, and actively maintained personal, moral, and professional boundaries between themselves and the floating population. This effectively divulged public health professionals of responsibility for the majority of the people who lived in their city and established them as "biological non-citizens" who had to be governed but could not be served. In doing this public health professionals worked to serve a civilized immigrant common of modern urban subjects that did not include the floating population. 3Relationships, Trust, and Truths chapter abstractThis chapter illustrates how the power to implement any given public health initiative in China was located within the webs of guanxi, or personal relationships, that public health professionals spun anew at the beginning of each project. Drawing on rich ethnographic description, the chapter takes the reader into the banqueting and other entertainment rituals that public health professionals engaged in almost daily in order to create and maintain these networks of reciprocal obligation and personalistic trust. The author then examines how a group of young, highly educated post-SARS reformers attempted to rid the public health system of guanxi, which they regarded as anti-scientific and akin to corruption. These reformers hoped to build a more transparent and reliable system of disease reporting and governance by establishing a professional common grounded in professionalized trust. 4Scientific Imaginaries chapter abstractThis chapter critically examines public health research and science in Tianmai. The author explores the efforts of Chinese public health professionals to advance their careers through scientific research, and discusses how in the wake of SARS, Chinese public health institutions dramatically increased their investments in scientific research – rendering publishable research a major focus of local public health work. Newly hired young people labored to produce the "quality" and "true" data that they associated with good science. They hoped that doing so would give them a chance to "develop themselves" as members of transnational scientific common, and to escape a local moral world that they felt was dominated by mimicry, deception, and instability. The chapter suggests that their approach to research provides a mirror through which public health researchers in other contexts could critically examine their own ethical practices, raising new questions about global research ethics. 5Pandemic Betrayals chapter abstractThis chapter provides an ethnographically rich eyewitness account of Tianmai's response to the 2009 H1N1 influenza pandemic, describing how public health professionals in Tianmai drew upon the lessons of SARS to mount what they thought would be an internationally lauded response to H1N1. In attempting to prove their pandemic preparedness capabilities and ensure a place among the global scientific elite, however, Tianmai's public health professionals instead found that their full admittance into a global health common and a global common remained elusive. The chapter discusses the professionals' difficulties in escaping their perceived status as a source, rather than a victim, of dangerous viruses; their use of disease control tactics that were portrayed abroad as excessive and unsophisticated; and their disappointment with the failure of their leaders and guanxi partners to act in the professional fashion that they had been trying to promote since SARS. 6Conclusion chapter abstractThe concluding chapter returns to the broader question of what professional responsibility can or should mean in public health and beyond, and asks how public health professionals in China could work to reconcile the "common" with the "population," and population needs with individual needs. The author uses the case of HIV/AIDS to examine the ways in which some public health professionals in Tianmai were experimenting with alternative interpretations of public health that broadened the boundaries of the common to allow in otherwise maligned groups, including rural migrants, gay men, and sex workers. The book ends by considering the implications of this ethnography for the study of public health – both local and global – more broadly.

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Book SynopsisA text for gerontology and geriatrics that focuses entirely on respiratory care. It provides a unique insight into the medical and psychosocial problems of the geriatric population. The text covers the various theories of aging and the issues of aging from the sociological perspective.Trade ReviewGerontology:The Study of Aging.Psychosocial Issues.Anatomic and Physiologic Changes in Later Life.Chronic Diseases of the Elderly.Pharmacology.Acute Disease of the Elderly.Long Term Care.The End of Life.Table of ContentsGerontology:The Study of Aging.Psychosocial Issues.Anatomic and Physiologic Changes in Later Life.Chronic Diseases of the Elderly.Pharmacology.Acute Disease of the Elderly.Long Term Care.The End of Life.

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Book SynopsisMoses Maimonides (1135-1204) remains one of the most celebrated rabbis in the history of Judaism, having written extensively on law, philosophy, religion and medicine. This text, the first volume of Maimonides' complete medical writings, is a complete regimen of health for an unnamed patient.

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Book SynopsisOffers Gerrit Bos' critical editions of all three surviving medieval Hebrew translations of Maimonides' work: one allegedly prepared by the fourteenth-century physician Samuel Benveniste; a second by Joshua Shatibi from Jativa between the years 1379 and 1390; and a third by an anonymous translator, possibly in the thirteenth century.

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Book SynopsisMore than 18 million Americans have Obstructive Sleep Apnea (OSA), but more than 90% of cases still remain undiagnosed. This source offers a thorough review of key considerations in the identification and treatment of OSA, and discusses issues often unaddressed in other publications on the topic, such as gender, age, drug interactions, and associated conditions to supply the clinician with best practices, expert recommendations, and clear-cut tables and guidelines for the care of patients with this disorder.Table of ContentsHistory and Physical Examination. Screening and Case Finding. PSG and Cardiorespiratory Monitoring. Upper Airway Imaging. Alertness and Sleepiness Assessment. CPAP. Bilevel Pressure and Adaptive Servo-Ventilation for Obstructive and Complex Sleep Apnea. Auto- Positive Airway Pressure. Critical Factors in Positive Pressure Therapy. Noninvasive Positive Ventilation. Upper Airway Surgery in the Adult. Oral Appliances. Adjunctive and Alternative Therapies. Gender Differences. Obstructive Sleep Apnea in Children. Obstructive Sleep Apnea in the Elderly. Medication Effects. Snoring and Upper Airway Resistance Syndrome (UARS). Central Sleep Apnea. Other Respiratory Conditions and Disorders. Other Sleep Disorders.Neurologic Disorders. Medical Disorders. Legal Implications of Obstructive Sleep Apnea. A Concluding Note and Future Directions

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Book SynopsisThe first reports of the successful use of mechanical ventilation to treat respiratory disorders in the neonate were published in the 1960s.Trade Review"Four Stars" "This is a complete overview of every aspect of respiratory interventions and assessments. I am very impressed with the chapters and information available of the new state-of-the-art ventilators and the wider ranges of modalities that are extensively covered. This information may help clinicans narrow the options when faced with so many choices and options in ventilaor management. The binding is also convenient and allows the pages to lay flat. The list of abbreviations is complete. Not only is there a detailed table of contents, but index as well. "I have had 17 years of neonatal experience and I find a great need for a current, updated manual to have as a reference in a Level III NICU. I appreciate involvement that respiratory care practitioners had with the physicians in the development of this manual. These contributors are widely respected and experts in the field." Doody’s Review Service "The manual with its large font size, simple line diagrams and easy to read text makes it a very readable book. It is strongly recommended for residents, consultants and nurses providing active neonatal respiratory support." Indian Paediatrics "The extent of coverage, easy readability, and superb organization in conjunction with the plethora of practical pearls make it worthwhile having access to this book in a bed-side library. For a price tag of $89.00, it is simply a great bargain." Journal of Perinatology "This is a complete book that covers what you need when taking care of critical infants with respiratory disease. It enhances the collaboration of the health care team in the NICU and promotes the team’s efficiency in managing these ill infants. By thoroughly understanding and applying the information in this volume, the survival rate in the NICU may be increased and the complication rate will decrease. Journal of Pediatric NursingTable of ContentsForeword. Alan H. Jobe. Preface. Abbreviations Used in This Book. Section I. Lung Development and Normal Pulmonary Physiology. Chapter 1. Development of the Respiratory System. (Vinod K. Bhutani). Chapter 2. Spontaneous Breathing. (Emidio M. Sivieri, Vinod K. Bhutani). Chapter 3. Pulmonary Gas Exchange. (Vinod K. Bhutani). Chapter 4. Pulmonary Mechanics. (Emidio M. Sivieri, Vinod K. Bhutani). Section II. Assessment of Cardiopulmonary Function. Chapter 5. Clinical Examination. (N.R.C. Roberton). Chapter 6. Radiography. (Lawrence R. Kuhns). Chapter 7. Interpretation of Blood Gases. (David J. Durand). Chapter 8. Neonatal Graphic Monitoring. (Joanne J. Nicks). Chapter 9. Continuous Monitoring Techniques. (Christian F. Poets, David P. Southall). Chapter 10. Echocardiography. (Jonathan P. Wyllie). Section III. Neonatal Respiratory Failure. Chapter 11. Indications for Mechanical Ventilation. (Anne Greenough, Anthony D. Milner). Chapter 12. Mechanisms of Respiratory Failure. (Anne Greenough, Anthony D. Milner). Chapter 13. Tissue Hypoxia. (Anne Greenough, Anthony D. Milner). Chapter 14. Neonatal Resuscitation. (Janet M. Rennie). Section IV. Mechanical Ventilation. Chapter 15. Basic Principles of Mechanical Ventilation. (Waldemar A. Carlo, Namasivayam Ambalavanan, Robert L. Chatburn). Chapter 16. Classification of Mechanical Ventilation Devices. (Waldemar A. Carlo, Namasivayam Ambalavanan, Robert L. Chatburn). Chapter 17 Ventilator Parameters. (Waldemar A. Carlo, Namasivayam Ambalavanan, Robert L. Chatburn). Section V. Conventional Ventilation. Chapter 18. Continuous Positive Airway Pressure. (Colin J. Morley). Chapter 19. Intermittent Mandatory Ventilation. (Cheryll K. Hagus). Chapter 20. Assist/Control Ventilation. (Steven M. Donn, Sunil K. Sinha). Chapter 21. Synchronized Intermittent Mandatory Ventilation. (Steven M. Donn, Sunil K. Sinha). Chapter 22. Volume-Controlled Ventilation. (Steven M. Donn, Kenneth P. Bandy). Chapter 23. Pressure Support Ventilation. (Sunil K. Sinha, Steven M. Donn). Chapter 24. Pressure Control and Pressure-Regulated Volume-Controlled Ventilation. (Mary K. Dekeon). Section VI. Neonatal Ventilator. Chapter 25. VIP BIRD® Infant/Pediatric Ventilator. (Michael A. Becker, Steven M. Donn). Chapter 26. Dräger Babylog 8000 Plus® Infant Care Ventilator. (Donald M. Null, Jr.). Chapter 27. SLE 2000® (HFO) Ventilator. (J. Harry Baumer). Chapter 28. Sechrist Model IV-200 SAVI® Ventilator. (S. David Ferguson). Chapter 29. Newport Wave® Ventilator. (Robert L. Chatburn). Chapter 30. Bear Cub 750 PSV® Infant Ventilator. (Cheryll K. Hagus). Chapter 31. Siemens Servo 300® Ventilator. (Mary K. Dekeon). Chapter 32. Infant Star® Ventilator. (Graham Bernstein). Section VII. Neonatal Apnea. Chapter 33. Apnea Syndromes. (Charles A. Pohl, Alan R. Spitzer). Chapter 34. Diagnosis of Apnea. (Charles A. Pohl, Alan R. Spitzer). Chapter 35. Treatment of Apnea. (Charles A. Pohl, Alan R. Spitzer). Section VIII. High-Frequency Ventilation. Chapter 36. General Concepts of High-Frequency Ventilation. (Bert Bunnell). Chapter 37. High-Frequency Jet Ventilation and the Bunnell Life Pulse® High-Frequency Jet Ventilator. (Martin Keszler). Chapter 38. High-Frequency Oscillatory Ventilation. (Reese H. Clark, Dale R. Gerstmann). Chapter 39. SensorMedics 3100A® High-Frequency Oscillatory Ventilator. (Jeanette M. Asselin). Section IX. Management of Specific Respiratory Disorders. Chapter 40. Respiratory Distress Syndrome. (Steven M. Donn, Sunil K. Sinha). Chapter 41. Meconium Aspiration Syndrome. (Thomas E. Wiswell). Chapter 42. Neonatal Pneumonia. (Roger G. Faix). Chapter 43. Persistent Pulmonary Hypertension of the Newborn. (Robert E. Schumacher, Steven M. Donn). Chapter 44. Neonatal Pulmonary Hemorrhage. (Tonse N.K. Raju). Chapter 45. Thoracic Air Leaks. (Kim K. Tekkanat, Steven M. Donn). Chapter 46. Congenital Diaphragmatic Hernia. (David Field). Chapter 47. Pulmonary Hypoplasia. (David Field). Chapter 48. Bronchopulmonary Dysplasia. (Jonathan M. Davis). Section X. Complications of Mechanical Ventilation. Chapter 49. Airway and Respiratory Complications of Mechanical Ventilation. (Steven M. Donn, Sunil K. Sinha). Chapter 50. Patent Ductus Arteriosus. (Jonathan P. Wyllie). Chapter 51. Neurologic Complications of Mechanical Ventilation. (Jeffrey M. Perlman). Chapter 52. Retinopathy of Prematurity. (Alistair R. Fielder). Section XI. Sedation and Control of Pain. Chapter 53. Assessment of Pain and Sedation. (Susan Kidd, Neil McIntosh). Chapter 54. Pharmacologic Intervention. (Gopi Menon, Christine A. Walker, Neil McIntosh.). Chapter 55. Effects of Inadequate Analgesia or Sedation. (Jan Reiss, Neil McIntosh). Section XII. Weaning from Mechanical Ventilation. Chapter 56. Essentials of Weaning. (Steven M. Donn, Sunil K. Sinha). Chapter 57. Weaning Strategies. (Steven M. Donn, Sunil K. Sinha). Chapter 58. Adjunctive Treatments for Weaning. (Steven M. Donn, Sunil K. Sinha). Chapter 59. Impediments to Weaning. (Steven M. Donn, Sunil K. Sinha). Chapter 60. Extubation and Postextubation Care. (Steven M. Donn, Sunil K. Sinha). Section XIII. Nursing Care. Chapter 61. Nursing Documentation. (Mary E. Linton). Chapter 62. Chest Physiotherapy/Postural Drainage. (Jill M. Neubert). Chapter 63. Endotracheal Tube Suctioning. (Mary E. Linton). Section XIV Special Procedures. Chapter 64. Laryngoscopy and Endotracheal Intubation. (Sam W. J. Richmond). Chapter 65. Replacing the Endotracheal Tube. (Sunil K. Sinha, Jonathan P. Wyllie, Steven M. Donn). Chapter 66. Transillumination. (Kim K. Tekkanat, Steven M. Donn). Chapter 67. Evacuation of Air Leaks. (Kim K. Tekkanat, Steven M. Donn). Chapter 68. Vascular Access. (Steven M. Donn, Kim K. Tekkanat). Chapter 69. Bronchoscopy. (Neil N. Finer). Chapter 70. Tracheostomy. (Steven M. Donn). Section XV. Pharmacologic Agents Used in Respiratory Care. Chapter 71. Surfactants. (Dharmapuri Vidyasagar). Chapter 72. Adjunctive Pharmacologic Agents. (Sam W.J. Richmond). Section XVI. Transport of Ventilated Babies. Chapter 73. Transport Equipment. (Steven M. Donn, Molly R. Gates). Chapter 74. Stabilization of the Transported Newborn. (Steven M. Donn, Molly R. Gates). Chapter 75. Special Considerations. (Steven M. Donn, Molly R. Gates). Section XVII. Alternative Therapies for Intractable Respiratory Failure. Chapter 76. Extracorporeal Membrane Oxygenation. (Robert E. Schumacher). Chapter 77. Inhaled Nitric Oxide Therapy. (Martha Nelson). Chapter 78. Liquid Ventilation for Neonatal Respiratory Failure. (David S. Foley, Ronald B. Hirschl). Section XVIII. Outcome of Neonatal Intensive Care. Chapter 79. Discharge Planning of the NICU Graduate. (Win Tin, Unni Wariyar). Chapter 80. Follow-Up of the NICU. (Graduate.Win Tin, Unni Wariyar). Section XIX. Ethical Considerations. Chapter 81. Initiation of Life Support at the Border of Viability. (Daniel G. Batton, Jeffrey Maisels). Chapter 82. Withdrawal of Ventilatory Support. (Malcolm L. Chiswick). Section XX. Ventilatory Case Studies. Chapter 83. Ventilatory Case Studies. (Marie C. McGettigan, Jay P. Goldsmith). Appendix. Index.

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Book SynopsisAn informative and enjoyable book introducing the condition Cystic Fibrosis to children and their families, providing comfort, hope, and key information. Featuring easy to understand language, helpful facts and fun color illustrations, this book is part of the innovative series The Strength of My Scars by surgeon, Maria Baimas-George.Table of ContentsCystic Fibrosis – Wacky Juice Machines.

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Book SynopsisAsthma can be caused and aggravated by occupational factors in working adults. Agents that are responsible for occupational asthma are either sensitizers or irritants. Prevention is important to reduce the impact of the disease. This new edition of Asthma in the Workplace focuses on recent developments that are reflected by an impressive addition to the scientific literature. This fifth edition retains key elements that have made the success of previous editions: worldwide contributors, variety of topics covered, presentation of key aspects using workplace scenarios and case histories. This new comprehensive edition is intended to be of interest for health professionals, researchers, students, practitioners and various professionals involved in the assessment and management of workers exposed to occupational factors that may cause or exacerbate asthma. Key Features Comprehensive coverage of all aspects of work-related asthma, includinTable of ContentsTable of Contents Part I : Introduction 1. Definition and classification of asthma in the workplace 2. Historical aspects of occupational asthma 3. Disease occurrence and risk factors 4. Mechanisms, genetics, and pathophysiology Part II : Assessment 5. Assessment of the worker 6. Assessment of the workplace 7. Immunological and inflammatory assessments 8. Functional assessment Part III : Management 9. Management of the worker 10. Prevention 11A. Impairment and disability evaluations: I. Psychosocial, economic, and medicolegal aspects 11B. Impairment and disability evaluation: II. Various legislations Part IV : Specific agents causing immunological occupational asthma 12. Occupational asthma in the baking industry 13. Asthma and allergy to animals, fish and shellfish 14. Polyisocyanates and their prepolymers 15. Western red cedar and other wood dusts 16. Metals 17. Cleaning agents 18. Various high- and low-molecular weight agents Part V : Specific disease entities and variants 19. Irritant-induced asthma and reactive airways dysfunction syndrome 20. Asthma exacerbated at work 21. Eosinophilic bronchitis 22. Occupational rhinitis 23. Airway diseases due to organic dust exposure 24. Occupational hypersensitivity pneumonitis and organic dust toxic syndrome 25. Chronic obstructive airway disease due to occupational exposure 26. Building-related illnesses and mold-related conditions 27. Occupational urticaria and allergic contact dermatitis

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Book SynopsisInhaled therapies form the cornerstone for treatment of patients with asthma and COPD. Evolving technology has resulted in availability of a wide range of devices for delivery of inhaled drugs. The four different delivery systems -- pressurized metered-dose inhalers, slow mist inhalers, dry powder inhalers, and nebulizers -- are unique in design and require distinct inhalational instructions for correct use. This book provides current information about inhalation devices, including their advantages and disadvantages, with guidance for optimal techniques of use. The book emphasizes appropriate selection of inhalation devices based on patient and health care professional factors as well as device attributes that allow selection of the right medication in the right inhalation device at the right time for the right patient.Key Features: Addresses the objective of precision medicine the right medication in the right inhaler device at the right time. Inputs by internationaTable of ContentsForeword. About the Editors. List of Contributors. Introduction. Principles of Inhaled Therapy. Goals of Pharmacotherapy for Asthma and COPD. Pressurized Metered-Dose Inhalers (pMDI). Spacers and Valved Holding Chambers. Slow Mist Inhalers. Dry Powder Inhalers. Digital Inhalers for the Management of Obstructive Lung Diseases. Nebulizers. Inhalation Therapy in Infants and Children. Selection of Inhaler Delivery System for Adult Outpatients. Inhalation Therapy in the Intensive Care Unit. Inhaled Therapy for Other Respiratory Diseases: Cystic Fibrosis and Non-Cystic Fibrosis Bronchiectasis. Inhaled Therapy for Other Respiratory Diseases: Pulmonary Hypertension. Regulatory Considerations Related to Inhaled. Delivery Systems. Index.

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Book SynopsisRespiratory diseases affect a large proportion of the population and can cause complications when associated with pregnancy. Pregnancy induces profound anatomical and functional physiological changes in the mother, and subjects the mother to pregnancy-specific respiratory conditions. Reviewing respiratory conditions both specific and non-specific to pregnancy, the book also addresses related issues such as smoking and mechanical ventilation. Basic concepts for the obstetrician are covered, including patient history, physiology and initial examinations. Topics such as physiological changes during pregnancy and placental gas exchange are discussed for the non-obstetrician. Guidance is practical, covering antenatal and post-partum care, as well as management in the delivery suite. An essential guide to respiratory diseases in pregnancy, this book is indispensable to both obstetricians and non-obstetric physicians managing pregnant patients.Trade Review'Overall, the book is quite timely given the current COVID-19 pandemic … The book is well written and easy to read. It provides excellent foundational knowledge … For the obstetrician, it is a great resource to facilitate more educated exchanges with consultants. For non-obstetricians consulted on obstetric patients, it provides a nice review of how pregnant women are different from non-pregnant adults. There are not many books dedicated to just the respiratory system, which makes it more valuable to healthcare providers looking for this specific type of information.' Vanessa Laibl Rogers, Doody's Book Review ServiceTable of ContentsList of contributors; Section 1. The Basics – for the Obstetrician: 1. Respiratory physiology and terminology Timothy Crozier; 2. Pulmonary assessment in pregnancy Tabassum Firoz; 3. Approach to common respiratory problems in pregnancy Karen Patterson; Section 2. The Basics – for the Non-Obstetrician: 4. Cardiopulmonary physiological alterations in pregnancy Niamh Hayes and Thomas Drew; 5. Gas exchange across the placenta Brahmdeep S. Saini, Janna L. Morrison and Mike Seed; Section 3. Pulmonary Conditions Not Specific to Pregnancy: 6. Pulmonary infections in pregnancy Priya Daniel, Timothy Hills and Wei Shen Lim; 7. Asthma in pregnancy Danish Ahmad and Erika Yoo; 8. Cystic fibrosis in pregnancy Melanie Chin and D. Elizabeth Tullis; 9. Restrictive lung disease in pregnancy Stephen Lapinsky; 10. Pulmonary thromboembolic disease in pregnancy Wee-Shian Chan; 11. Pulmonary hypertension in pregnancy Liesbeth ten Klooster, Vicki J. Wilson, Ruth Newton, Karen Selby, Suarabh V Gandhi and David G Kiely; 12. Sickle chest syndromes in pregnancy Ann Kinga Malinowski and Nadine Shehata; 13. Sleep-disordered breathing in pregnancy Jennifer E. Dominguez and Ghada Bourjeily; 14. Acute respiratory distress syndrome and respiratory failure in pregnancy Justin Seashore and Alexander Duarte; 15. Other pulmonary conditions in pregnancy Muhammed Ehtisham, Humnah Khudayar and Patricia Russo-Magno; Section 4. Pulmonary Conditions Related to Pregnancy: 16. Dyspnea of pregnancy Stephen Lapinsky and Ghada Bourjeily; 17. Amniotic fluid embolism syndrome Marie Baldisseri; 18. Pregnancy-associated pulmonary edema Lisa Moore; Section 5. Other Pulmonary Issues in Pregnancy: 19. Smoking in pregnancy Catherine Chamberlain; 20. Radiological imaging of the chest in pregnancy Shital Gandhi and Siobhan Bacon; 21. Respiratory drug therapy in pregnancy Nika Mehta; 22. Biological and immunosuppressive respiratory therapy in pregnancy Bernadette Jenner and Catherine Nelson-Piercy; 23. Oxygen therapy in pregnancy Daniela Vaquez and Gustavo A. Plotnikow; 24. Airway management in pregnancy Kyle Jespersen and Michaela K. Farber; 25. Mechanical ventilation in pregnancy José Rojas-Suarez and Jezid Miranda; Index.

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Book SynopsisMolecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence.Table of ContentsContributors xi Preface xiii 1 The Demography of Aging 1 David E. Bloom and Sinead Shannon 1.1 Introduction 1 1.2 Demographic trends 1 1.2.1 Fertility rates 2 1.2.2 Mortality rates and life expectancy 2 1.2.3 Proportion of older people 3 1.3 Impact of aging 4 1.3.1 Noncommunicable disease trends 4 1.3.2 Risk factors 5 1.3.3 Impact of NCDs on health and disability 6 1.3.4 Increase in multimorbidities 7 1.3.5 Impact on expenditure 7 1.4 Policy responses 8 1.4.1 Preventing and managing NCDs 8 1.4.2 Promoting exercise 9 1.4.3 Monitoring health-risk behaviors (and chronic health conditions) 9 1.5 Conclusion 9 References 10 2 The Omics of Aging: Insights from Genomes upon Stress 13 Ismene Karakasilioti, Anna Ioannidou, and George A. Garinis 2.1 Introduction 13 2.2 Safeguarding the nuclear genome 14 2.3 NER progerias and their connection to lifespan regulatory mechanisms 15 2.4 Triggering a survival response in the absence of a DNA repair defect 16 2.5 The omics connection between progeria and longevity 19 2.6 Triggering of systemic versus cell-autonomous features of the survival response 20 2.7 The omics connection between NER progeria, transcription, and longevity 21 2.8 Future perspectives 22 References 22 3 Protein Quality Control Coming of Age 27 Silke Meiners 3.1 Introduction 27 3.2 The aging molecular chaperone network 29 3.3 Protein degradation pathways in aging 30 3.3.1 Lysosomal autophagy pathway 30 3.3.2 Ubiquitin–proteasome system 32 3.4 Compartment-specific protein quality control 34 3.4.1 The aging ER stress response 34 3.5 Conclusion 35 References 35 4 Telomerase Function in Aging 41 Rodrigo T. Calado 4.1 Telomeres 41 4.2 Telomerase 43 4.3 Telomeres and human disease 45 4.3.1 Telomere dysfunction in the lungs 46 4.4 Telomeres biology, aging, and longevity 47 4.5 Conclusion 48 References 48 5 The Cellular Senescence Program 53 Pooja Shivshankar and Claude Jourdan Le Saux 5.1 Cellular senescence and evidence of senescence in a cell 53 5.1.1 Characteristics of senescent cells and the inflammatory microenvironment 53 5.1.2 Detection of senescent cells in vitro and in vivo 54 5.2 Conditions associated with cellular senescence 55 5.2.1 Oxidative stress 55 5.2.2 DNA damage 55 5.2.3 Cell cycle arrest and senescence 56 5.3 Mechanisms/pathways of senescence induction 56 5.3.1 The p53/p21 pathway 56 5.3.2 The p16/pRB pathway 57 5.3.3 Convergence/coactivation of p53/p21 and p16/pRB pathways 57 5.3.4 Induction of senescence via molecular signaling 57 5.4 Cellular senescence in aging and age-related diseases of the lungs 58 5.4.1 Normal aging 59 5.4.2 Pneumonia 59 5.4.3 Chronic obstructive pulmonary disease 60 5.4.4 Idiopathic pulmonary fibrosis 60 5.5 Conclusion 61 References 61 6 Signaling Networks Controlling Cellular Senescence 67 Leena P. Desai, Yan Y. Sanders, and Victor J. Thannickal 6.1 Introduction 67 6.2 Classification of cellular senescence 69 6.2.1 Intrinsic pathway 69 6.2.2 Extrinsic pathway 69 6.2.3 Reversibility of cellular senescence 70 6.3 Cross talk of signaling pathways 70 6.3.1 Protein kinases 70 6.3.2 Metabolic pathways 71 6.3.3 Mitochondria and reactive oxygen species 71 6.3.4 Integrin and focal adhesion signaling 72 6.3.5 Transforming growth factor-β1 73 6.3.6 Epigenetic mechanisms 73 6.4 Conclusion 76 References 77 7 Immune Senescence 85 Kevin P. High 7.1 Introduction 85 7.2 Barrier defenses and innate immunity in older adults 86 7.2.1 Barrier defenses 86 7.2.2 Innate immunity 86 7.3 Adaptive immune responses 88 7.3.1 B cell number and function 88 7.3.2 T cell number, subtypes, and function 89 7.3.3 T cell activation, differentiation, exhaustion, and senescence 90 7.4 Consequences of immune senescence 91 7.4.1 Impaired vaccine responses, increased risk of infection, and age-related illness 91 7.4.2 Immune senescence: A cause of aging itself 93 7.5 Conclusion 94 References 95 8 Developmental and Physiological Aging of the Lung 99 Kent E. Pinkerton, Lei Wang, Suzette M. Smiley-Jewell, Jingyi Xu, and Francis H.Y. Green 8.1 Introduction 99 8.2 The aging lung 99 8.2.1 Alterations in lung function and anatomy 99 8.2.2 Oxidative stress and lung antioxidant defenses 101 8.2.3 Immune system changes with aging 101 8.2.4 Body mass 102 8.2.5 Airway receptor and endocrine changes with aging 103 8.3 An animal model of the aging lung: The rat 104 8.3.1 The tracheobronchial tree and epithelium of the aging rat 104 8.3.2 Parenchymal lung structure in the aging rat 105 8.3.3 Alveolar tissue compartments 106 8.4 Conclusion 110 Acknowledgments 110 References 111 9 Mouse Models to Explore the Aging Lung 117 Mingyi Wang and Deepak A. Deshpande 9.1 Pulmonary changes during aging 117 9.1.1 Advantages of mouse models for studying physiological lung changes 118 9.2 Key findings from mouse models of aging 119 9.2.1 Longevity and lung function in mice 120 9.2.2 Different strains of mice have different alterations in lung mechanics 120 9.2.3 Transgenic mouse model to study aging in the lungs 121 9.3 Age is a risk factor for obstructive pulmonary diseases 123 9.4 Challenges ahead 124 9.5 Conclusion 125 Acknowledgments 126 References 126 10 Evidence for Premature Lung Aging of the Injured Neonatal Lung as Exemplified by Bronchopulmonary Dysplasia 131 Anne Hilgendorff 10.1 Introducing bronchopulmonary dysplasia 131 10.2 Altered pulmonary function in infants with BPD 132 10.3 Response to injury 133 10.3.1 Oxidative stress response 134 10.3.2 Extracellular matrix remodeling 136 10.3.3 Inflammation 136 10.3.4 Morphogenetic response 137 10.4 Prenatal and genetic predisposition 137 10.5 Conclusion 138 References 138 11 Remodeling of the Extracellular Matrix in the Aging Lung 145 Jesse Roman 11.1 Introduction 145 11.2 The aging lung 145 11.3 Activation of tissue remodeling in the senescent lung 146 11.4 The aging lung fibroblast 148 11.5 Potential role of oxidant stress in triggering remodeling in the aging lung 149 11.6 Implications for remodeling of the lung extracellular matrix in the aged lung 150 11.7 Conclusions 152 Acknowledgments 154 References 154 12 Aging Mesenchymal Stem Cells in Lung Disease 159 Maria G. Kapetanaki, Ana L. Mora, and Mauricio Rojas 12.1 Aging and lung diseases 159 12.2 Mesenchymal stem cells (MSCs) 160 12.2.1 Description of MSCs 160 12.2.2 Characterization of MSCs 160 12.2.3 Functional properties of MSCs 161 12.3 Impact of aging on mesenchymal stem cells 162 12.3.1 In vitro aging of MSCs 162 12.3.2 Age-related changes in B-MSCs 163 12.3.3 Aging of B-MSCs versus aging of the organism 163 12.4 B-MSCs in disease 164 12.5 B-MSCs in therapy 166 12.5.1 Ex vivo expansion 166 12.5.2 Conditions affecting the expansion 167 12.5.3 Autologous versus allogeneic B-MSCs 167 12.5.4 Combination of cell preparations 167 12.5.5 Delivery and targeting 167 12.6 Conclusion 167 Acknowledgments 168 References 168 13 COPD as a Disease of Premature Aging 173 Laurent Boyer, Jorge Boczkowski, and Serge Adnot 13.1 Introduction 173 13.2 Senescent cells contribute to the pathogenesis of COPD 174 13.2.1 Accumulation of senescent cells in COPD lungs 174 13.2.2 Inflammation and lung-cell senescence in COPD 175 13.2.3 Emphysema and lung-cell senescence in COPD 176 13.2.4 Pulmonary hypertension and cell senescence in COPD 177 13.3 Lung dysfunction and the general process of premature aging in COPD 179 13.3.1 Clinical manifestations of premature aging in COPD patients 179 13.3.2 Role for lung alterations in systemic premature aging during COPD 180 13.4 Conclusion 181 References 181 14 Lung Infections and Aging 185 Jacqueline M. Kruser and Keith C. Meyer 14.1 Introduction 185 14.2 Aging and immunosenescence 185 14.2.1 Innate immunity 187 14.2.2 Adaptive immunity 188 14.2.3 Autoimmunity 189 14.2.4 Lung-specific changes in immunity with aging 190 14.3 Inflamm-aging and susceptibility to infection 190 14.4 Respiratory infection and regulation of host responses 192 14.5 Preventing respiratory infection 194 14.6 Summary and conclusions 195 References 195 Index 201

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Book SynopsisA succinct yet comprehensive overview of respiratory medicine, written for students and professionals Essential Respiratory Medicine is an indispensable text offering an understanding of respiratory conditions and their clinical management within evidence-based guidelines. Containing information on taking a medical history, performing examinations and investigations, diagnosis and the management of respiratory conditions, this comprehensive text was put together by a noted expert in the field. Written in an accessible manner, Essential Respiratory Medicine contains the foundational science associated with respiratory medicine, a wide-variety of practical procedures, helpful diagrams, and self-assessments designed to enhance understanding of the material presented. The text covers a variety of conditions as well as providing suggestions for engaging with patients at different stages of care. This important resource: Demonstrates an effective approach to patients presenting with common respiratory symptoms Includes a description of all key practical procedures with diagramsDiscusses acute management of important respiratory emergenciesCovers both acute and chronic diseaseContains a companion website containing a range of learning materials, including downloadable management summaries and algorithms, an image bank, videos of patient examination, example respiratory sounds and multiple-choice questions Essential Respiratory Medicine is an essential resource for anyone on a clinical placement, rotation, or training programme in respiratory medicine.Table of ContentsAbout the author ix Acknowledgements xi About the companion website xiii 1 Introduction to respiratory medicine 1 2 Embryology, anatomy, and physiology of the lung 5 3 Pharmacology of the lung 29 4 Common respiratory investigations 51 5 Common presentations of respiratory disease 83 6 Obstructive airways disease 105 7 Diffuse parenchymal lung disease 137 8 Respiratory infections 173 9 Lung cancer 205 10 Pleural disease 235 11 Pulmonary embolus, pulmonary hypertension, and vasculitides 267 12 Suppurative lung disease 293 13 Respiratory failure 317 14 Sleep‐related disorders 333 15 Occupational, environmental, and recreational lung disease 353 16 Disorders of the mediastinum 369 17 Acute lung injury and acute respiratory distress syndrome 383 Index 395

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