Reproductive medicine Books

Book SynopsisA compelling and groundbreaking defence of Hormone Replacement Therapy (HRT) from two expert authors

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Book SynopsisFully revised for this fourth edition, the Oxford Handbook of Obstetrics and Gynaecology fully reflects new developments in the field. Featuring new sections on the outcomes of the MBRRACE report, abnormally adherent and invasive placenta, pregnancies in mothers of advanced age, assisted reproduction, and ovarian cancer screening, it provides a contemporary overview of this complex and important specialty.Written and reviewed by a team of highly experienced clinicians, academics, and trainees, this Handbook is a perfect starting point for preparation for postgraduate exams. Practical advice is presented with key evidence-based guidelines, supported by visual algorithms and top clinical tips.The previous edition was Highly Commended in the Obstetrics and Gynaecology category of the BMA Book Awards. The indispensable, concise, and practical guide to all aspects of obstetric and gynaecological medical care, diagnosis, and management, this fourth edition continues to be the must-have resource for all specialist trainees, junior doctors, and students, as well as a valuable aide memoire for experienced clinicians.Trade ReviewThe book itself is superb value for money, considering its scope of coverage and general excellence and if someone thinks they will be a regular user then I am sure they will like this book. It maintains the excellence of the other members of the Oxford Medical Handbooks series and users who are familiar with other books in the series, will know what to expect. * Dr Harry Brown, Geriatric Medicine *Review from previous edition Very reader-friendly and the style is very easy to absorb for a junior doctor especially if new to O&G... Its strength is that it is user-friendly and good core clinical knowledge and practice is covered for junior doctors. * BMA Book Awards 2014. Highly Commended *This is a solid contribution for UK obstetricians/gynecologists * Doody's Notes *Table of Contents1: Normal pregnancy 2: Pregnancy complications 3: Fetal medicine 4: Infectious diseases in pregnancy 5: Medical disorders in pregnancy 6: Labour and delivery 7: Obstetric anaesthesia 8: Neonatal resuscitation 9: Postnatal care 10: Obstetric emergencies 11: Maternal and perinatal mortality 12: Benign and malignant tumours in pregnancy 13: Substance misuse and psychiatric disorders 14: Gynaecological anatomy and development 15: Normal menstruation and its disorders 16: Early pregnancy problems 17: Genital tract infections and pelvic pain 18: Subfertility and reproductive medicine 19: Sexual assault 20: Contraception 21: Menopause 22: Urogynaecology 23: Benign and malignant gynaecological conditions 24: Miscellaneous gynaecology

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Book SynopsisThe definitive text for medical students and residents in plastic surgery, Grabb and Smith’s Plastic Surgery, Ninth Edition, covers every aspect of this challenging field in up-to-date, easy-to-understand detail. Superb illustrations, convenient key points, and relevant review questions help you develop a deeper understanding of basic principles and prepare effectively for the In-Training Exam (ITE) and other certification exams. Dr. Kevin C. Chung leads a team of expert contributing authors to create a fully revised resource that also serves as a reference for practicing plastic surgeons to refresh knowledge and to enhance competency in various topics. Coverage includes all areas of plastic surgery: basic science, principles and techniques, skin and soft tissue topics, congenital anomalies and pediatric plastic surgery, head and neck surgery, aesthetic surgery, breast surgery, body contouring, hand surgery, and trunk and lower extremity surgery.   Offe

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Book SynopsisThis book is designed to meet the needs of nurse practitioners, other advanced practice nurses, and allied health professionals working in women’s health, primary care, and other specialties. The multiple roles the clinician embraces in menopause management include that of direct caregiver, manager of therapeutics, educator, and interdisciplinary team member or leader. This book provides updated, evidence based information on the menopause transition from the late reproductive stage to post-menopause to optimize the interaction of the clinician and the individual woman in each of those roles. Women’s lived experiences of menopause and women’s concerns regarding both the menopause transition and the choice of care options are included as critical components of shared therapy decisions. The review of natural menopause physiology and the variability of menopause symptoms are inclusive of diverse women and diverse trajectories. The impact of menopause on chronic disease, sleep, weight and nutrition, mood and cognition, urogenital health and sexuality, as well as vasomotor symptoms are each developed as individual topics by experts in those fields. Evidence based management using hormonal and non-hormonal options, and life-style and other complementary interventions are discussed with the most updated advantages and disadvantages of each treatment option. Consistent with advanced practice nursing theory, the approach is whole patient focused. Table of ContentsPreface Author Patricia Geraghty MSN, FNP-BC, WHNP · Philosophy of inclusion · Attention to individuality Introduction Patricia Geraghty MSN, FNP-BC, WHNP Author Patricia Geraghty MSN, FNP-BC, WHNP · Analysis of the cultural view of menopause from that primarily generated through observation, developing into evidence from controlled studies. · Effect of extended lifespan establishing the common and prolonged role of menopause in a woman’s life. · Role of advanced practice nurse and allied health professionals through the ages with a focus of current and future role development. PART 1 PHYSIOLOGY AND WOMEN’S PERSPECTIVE OF THE MENOPAUSE TRANSITION Chapter 1 Physiology of Menopause Transition Author Patricia Geraghty MSN, FNP-C, WHNP · Hypothalamus Pituitary Ovarian Axis and control of the menstrual cycle · Normal physiological changes from aging oocytes, hormonal and cycle fluctuations · Time frame of natural transition · Iatrogenic menopause and primary ovarian insufficiency · Estrogen receptors in tissue other than the reproductive system · Menopause symptom profile including individual and ethnic variations in symptom presentation Chapter 2 Women’s Lived Experience of the Menopause Transition Author Nina Coslov, Activist. WomenLivingBetter.org · Women’s surprise about how soon menopause changes begin. · Impact of menopause on families and partners · Help seeking behavior - Women’s quotes and voices on their experiences of symptoms and in seeking help. · Patient resources and support groups - Overview of Online Resources where women find information and support. o Experts with Products and Programs o Websites/Blogs o Telehealth offerings o Social Media groups/communities § Women are grateful to have a place to feel heard and connect. § Impact of question/answer format in absence of clinical monitoring Chapter 3 Menopause and Chronic Disease Interaction Author Patricia Geraghty MSN, FNP-C, WHNP · Menopause interaction with leading causes of death and chronic disease: cardiovascular, lung, dementia, kidney, diabetes, arthritis, cancer. · Influence of ethnicity on menopause and chronic disease interaction · Contribution of menopause hormone therapy where known. Chapter 4 Effective Communication with Women in the Menopause Transition Author Juliette Blount MSN, NP. Health Equity Activist, Women’s Health NP · Establishing a trusting and supportive relationship · Gathering information: health history includes race, ethnicity, and culture, lived experience of her menstrual cycles, thoughts and beliefs of the menopause transition, symptoms, thoughts and beliefs of menopause management · Providing information: Provide detailed information about the options that are in alignment with the information that you gathered, focus on informed and shared decision making · Open ended leaving room for questions and alterations in management plan PART 2 MENOPAUSE SYMPTOM MANAGEMENT Chapter 5 Vaginal Bleeding Author Patricia Geraghty MSN, FNP-BC, WHNP · Recap physiology and transition from mid-reproductive stage to perimenopause to post menopause. · Incidence, management and consequences of heavy bleeding including ethnic variation. o Co-morbidities of uterine fibroids, coagulation disorders and other etiologies of heavy menstrual bleeding. · Incidence, management and consequences infrequent bleeding. o Unintended pregnancy in perimenopause and co-morbidities of PCOS, endometrial hyperplasia and atypia. · Incidence, management and consequences of post-menopause bleeding. o Co-morbidities of genital carcinomas. Chapter 6 Vasomotor Symptoms Author Patricia Geraghty MSN, FNP-BC, WHNP Recap physiology and extent of problem, including ethnic variations. · Consequences of failure to treat. · Pharmacological management and risk/benefit of hormones and non-hormone products, evidence for complementary therapy and lifestyle changes. Chapter 7 Breast Health Author Michelle Frankland NP (corresponding), Mariya Rayazantseva NP, Trish Brown MS, CGC Recap of the physiological effect of menopause on breast health and the effect of hormonal management on breast health · The role of genetics in breast health · The woman of average risk, the woman of high risk, and ethnic variations · The role of breast health screening and modalities of screening in menopause · Management of menopause for the woman at high risk of breast cancer, including complementary and behavioral therapy. Chapter 8 Mood and Cognition: Author Eleanor Bremer PhD, RN, FNP-BC · History of evidence mood related to the female endocrine events of menstruation, pregnancy, postpartum and menopause. o Perimenopause prolonged PMS symptoms. o Depression and anxiety associated with menopause transition as a small subset. Management. Prognosis · Impact on women, their partners, and families · Association of dementia with menopause and menopause management options. · Management including pharmacological, complementary, and behavioural therapy. Chapter 9 Vaginal and Sexual Health Author Patricia Geraghty MSN, FNP-BC, WHNP · Recap physiology and extent of sexual response and genitourinary changes in menopause. · Impact on women and their partners · Consequences of genital tissue changes related to pain, incontinence, infection. Management including pharmacological, complementary, and behavioural therapy · Sexual health: genital and CNS contribution. Diagnostic criteria. Management. Chapter 10 Skin and Integument Author Denise Hilliard MD, Medical Director, Internal and Aesthetic Medicine · Overview of Skin/Hair changes in menopause: Structure of skin and hair follicle, Hormone receptors in skin and hair follicle o Physiologic changes in skin and hair due to hormone shifts in menopause: hair loss, skin dryness, decrease in skin elasticity, decrease in skin thickness · Concomitant solar-skin changes (sun damage) affecting skin in menopause: Hyperpigmentation, Fine lines and wrinkles, Pre-cancerous and cancerous skin growths · Caring for skin and hair during menopause o UVA/UVB protection o Skin self-exam and skin cancer screening by clinician o Treatment of focused skin and hair concerns § Dry skin § Easy bruising § Unwanted facial hair § Hair loss/ hair thinning § Loss of elasticity/wrinkles/loss of volume § Menopausal acne § Rashes/Skin Irritation/Rosacea § Delayed wound healing · Role of menopause hormone therapy and complementary and behvioral therapy for skin concerns Chapter 11 Musculoskeletal: Bone Health, Arthralgia and Myalgia Author Kathleen Geier DNP, FNP-C, ONC, AJ Benham DNP, FNP-C, ONC · Recap osteoporosis and menopause: the physiology of bone loss o Risk factors and the influence of hormones on osteoporosis prevention o Use of the 10-year fracture risk assessment tool (FRAX) in clinical practice o What is sarcopenia and how is it related to bone health in menopause · Common musculoskeletal pain during menopause: myalgia and arthralgia · Lifestyle and nutritional optimization for bone and joint health related menopause · Evidence-based clinical treatment guidelines for post-menopausal osteoporosis including complementary and behavioral therapy. Chapter 12 Nutrition and Weight Management Author Maya Feller MS, RD, CDN · Ethnic and cultural dietary patterns and their impact on nutrition-related health outcomes in menopause · The impact of social determinants of health in the development of positive energy balance, insulin resistance, type II diabetes, elevated lipids and hypertension · Menopause focused nutrition intervention and management of: o Positive and negative energy balance / weight management o Disorders of glucose metabolism: insulin resistance, impaired glucose tolerance & diabetes o Disorders of lipid metabolism o Hypertension · Reducing the risk of nutrient deficiency focused on nutrients of concern as related to bone health, lean body mass preservation, cardiovascular health Chapter 13 Sleep Disruption and Stress Management Author Rebecca Berke BCH, Olivia Crowell BSN RN · Recap physiology and extent of sleep disruption in menopause. · Consequences inadequate sleep. · Gold standard Cognitive Behavioral Therapy for insomnia: sleep education and mindfulness. · Pharmacotherapy and supplements risks/benefits. Complementary therapy.

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Book SynopsisHelping the Stork The sourcebook for all the information parents-to-be need to know about the choices and challenges of donor insemination Each year donor insemination (DI) offers a pathway to parenthood for the hundreds of thousands who turn to family-building alternatives. Although DI is considered as often as adoption, couples facing male infertility, as well as single women and lesbian couples, have had few places to turn for information about this method, which has been shrouded in secrecy. In Helping the Stork, parents-to-be, as well as friends and family, doctors, and counselors, can explore the choices and challenges raised by this alternative to overcoming childlessness. This comprehensive handbook moves through each step of the process: reaching a solid decision about whether donor insemination is the best choice for a family's future; handling the difficult issue of privacy; selecting a donor and getting started; and learning to thrive as a family meeting DI's added challengTable of ContentsA Note on Terminology. Introduction. Chapter One--Family Building: DI as an Option. Chapter Two--Facing Tough Choices. Chapter Three--Understanding Your Donor Options. Chapter Four--Getting Started. Chapter Five--Trying Times: When Donor Insemination Takes Its Time. Chapter Six--Becoming Pregnant: Shock, Relief, Fear, and Joy. Chapter Seven--Growing with DI. Chapter Eight--Changing Families, Different Challenges. Chapter Nine--Guiding Those Who Care: Advice for Confidants. Chapter Ten--Humor in Hindsight. Resources. Endnotes. Bibliography. Index.

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Book SynopsisThis book gives an overview of the potential and the practical details that need to be resolved to make human germline engineering possible. Chapters present the ethical and social concerns and implications of the fast-approaching capability to alter the human germline and take an active role in the future evolution of the species.Trade ReviewThe book should be commended for bringing to the fore the possibilityof germline manipulation within the next decade * New Genetics & Society *...interesting reading. * Heredity *The participants, mostly drawn from Us academic institutions, fall into three categories: eminent practising scientists; panelists, including James Watson, the co-discoverer of the structure of DNA; and commentators- scientists, ethcicists and theologians * Nature *Table of ContentsSection One ; 1. A vision for human germline engineering ; 2. The human genome project - launch pad for human genetic engineering ; 3. Ethics and Safety ; 4. Human germline gene therapy: how and why ; 5. A new front in the battel against disease ; 6. Aging as a target for genetic engineering ; 7. Reprogenetics: how reproductive and genetic technolgies will be combined to provide new opportunities for people to reach their reproductive goals ; Section Two ; Panel: The road ahead ; Section Three"R ; 1. Other voices - Introduction ; 2. Parental choices ; 3. Thoughts on the... ; 4. The psycho-social limits on human germline modification ; 5. Do we know ourselves well enough to be engineering humans? ; 6. Germline manipulation ; 7. Maximize parental choice ; 8. Our societal obligations for keeping human nature untouched ; 9. The question of purpose ; 10. Gene modification technology ; 11. Justice and the germline ; 12. Human germ line intervention: What's the fuss about? ; 13. Germline culture: The genetics of hubris ; 14. Liberty, equality, and solidarity in our genetically engineered future ; 15. Would humanity be better off...Or, what would it be better for? ; 16. Human dignity should not keep us from genetically engineering our children ; 17. Universal bioethics for the human germline ; 18. Multi-jurisdiction regulation of germline intervention 'A policy with neither virtue nor prospect of success ; Section 4. Chapter Contributors and Essay Contributors

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Book SynopsisAll persons, while different from one another, have the same value: this is the author''s relatively uncontroversial starting point. Her end point is no uncontroversial: an ideal of justice as human flourishing, based on each person''s unique set of capabilities. Because the book''s focus is women''s health care, gender justice, a necessary component of justice, is central to examination of the issues. Classical pragmatists and feminist standpoint theorists are enlisted in support of a strategy by which gender justice is promoted.Two features of the book are unique: (1) the topics presented cover the entire life span of women, not just those related to reproduction; (2) a range of views about moral status are applied not only to fetuses but also to individuals already born. Attention to these features is intended to facilitate ethical consistency or moral integrity and respect for those who hold different moral views.While delineating and defending the book''s perspective, the first section provides an overview of bioethics, critiques prevalent approaches to bioethics and models of the physician-patient relationship, and sketches distinguishing aspects of women''s health care that are prevalently neglected. Positions about moral status are also present.The second section identifies topics that are indirectly as well as directly related to women''s health, such as domestic violence and caregiving. Brief cases illustrate variables relevant to each topic. Empirical and theoretical considerations follow each set of cases; these are intended to precipitate more expansive and critical examination of the issues raised.The last section is devoted to an egalitarian ideal that may be pursued through an ethic of virtue or supererogation rather than obligation. By embracing this ideal, according to the author, moral agents support a more demanding level of morality than guidelines or laws require.Trade Reviewone of the nice aspects of this book is the extensive body cases that Mahowald employs. While other works in medical ethics tend to either present an abundance of cases without any analysis or a small number of cases with extensive analysis, this book succeeds in giving us a text that achieves both a wide range of cases and analyses sufficient to stimulte thoughtful discussion. * Leah McClimans, Ethical Theory and Moral Practice *Mahowald succeeds in presenting a diverse series of bioethical issues relating to women's health. Her analysis is often sophisticated and original. * Medical Health Care and Philosophy journal *her [Mahodwald's] ethics stand as a postmodern ideal * Michele Pridmore-Brown, TLS01/06/07 *This is a well-written, thought-provoking book and a welcome addition to any library. * Doody's Notes *Table of ContentsPART ONE: A BIOETHICS FOR WOMEN; PART TWO: TOPICS, ISSUES, AND CASES; PART THREE: AN EGALITARIAN IDEAL

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Book SynopsisA history of prenatal testing that shows it to be more complicated than a simple medical advance, bringing with it a host of questions about ethics and responsibility.

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Book SynopsisA history of prenatal testing that shows it to be more complicated than a simple medical advance, bringing with it a host of questions about ethics and responsibility.

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Book SynopsisThis study examines the social context and current state of reproductive mediating technologies, such as artificial insemination, in vitro fertilization, surrogate motherhood, DNA probes and sterilization. It also explores the impact of this technology on the concepts of family and parenthood.

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Book SynopsisPeriod positivity starts with asking questions.This informative, irreverent, and absorbing book covers all your period-related questions - why they''re taboo (and needn''t be) and how to navigate the whole bleeding thing, from first periods to fertility, euphemisms to uteruses, menstrual products to menopause.Let''s get period positive. It''s about bloody time.Feel your best at any time of the month! This science-backed menstruation book is full of good advice and friendly tips to give you the tools to re-frame your thinking and learn to love your cycle.This frank, funny, and fascinating menstruation guide from Period Positive movement founder and menstrual researcher, Chella Quint''s offers:- A practical, science-backed guide to your period with arresting infographics, and anatomical diagrams- Answers to all your period-related questions, exploring topics like the functions and effects of hormones, when periods normal

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Book SynopsisTrade ReviewJames A. Winans-Herbert A. Wichlens Memorial Award for Distinguished Scholarship in Rhetoric and Public Address, National Communication Association (NCA), 2020 "Despite the devastating picture Homeland Maternity paints, it provides glimpses of hope. . . . Fixmer-Oraiz reminds us that the dominant narratives, especially narratives about women, are not always accurate. There are better stories we could be telling." --Christian Century"I love Homeland Maternity. It's brilliantly conceived, broadly interpretive and intersectional, wisely written, politically astute, and very useful. I wanted to underline nearly every sentence. Fixmer-Oraiz has crafted an extremely smart and scary book."--Rickie Solinger, coauthor, Reproductive Justice: An Introduction"Fixmer-Oraiz powerfully articulates how reproductive justice and homeland maternity provide scholars and activists the vocabularies and interpretive frameworks to interrogate and disrupt dominant mechanisms that are used to police individuals' reproductive lives. Homeland Maternity is intellectually rigorous, forceful, and timely to the current sociopolitical context. It can and should inform future studies in rhetoric, media studies, and gender and women's studies." --Women's Studies in Communication"In this clearly written and cogently argued book that ranges across a broad array of public discourse, Natalie Fixmer-Oraiz brings into focus the disturbing intersections between reproductive politics and national security in the post-9/11 era. Historically and theoretically informed, Homeland Maternity makes clear that the regulation of women's bodies is a key weapon in struggles over nationalism, nativism, and the meaning of security."--Bonnie J. Dow, author of Watching Women's Liberation, 1970: Feminism's Pivotal Year on the Network News"Decidedly grounded in an ethic of reproductive justice and its bringing together of 'feminist studies of maternal and reproductive politics and critical scholarship on homeland security culture,' (3-4) Natalie's homeland maternity provides a necessary and nuanced framework for naming and understanding complex, urgent events around reproductive politics today." --IZG OnZeit"A must-read for scholars interested in contemporary motherhood and/or the rhetoric of security. In Homeland Maternity, Fixmer-Oraiz offers an incisive analysis of an eclectic set of texts to illuminate how the long-standing connections between discursive"This book is devastatingly good. Good because it is elegantly written, tightly argued, and theoretically informed and informative. Devastating because it makes clear that a nasty thicket of laws, institutions, and rhetoric values pregnancy (even a potential pregnancy) more than the integrity, safety, and humanity of women, pregnant people, and mothers. I have long followed public policy debates over reproductive health care. Fixmer-Oraiz's conclusions should not have surprised me and the examples should not have horrified me. But they did." --Argumentation and Advocacy

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Book SynopsisTrade ReviewJames A. Winans-Herbert A. Wichlens Memorial Award for Distinguished Scholarship in Rhetoric and Public Address, National Communication Association (NCA), 2020 "Despite the devastating picture Homeland Maternity paints, it provides glimpses of hope. . . . Fixmer-Oraiz reminds us that the dominant narratives, especially narratives about women, are not always accurate. There are better stories we could be telling." --Christian Century"I love Homeland Maternity. It's brilliantly conceived, broadly interpretive and intersectional, wisely written, politically astute, and very useful. I wanted to underline nearly every sentence. Fixmer-Oraiz has crafted an extremely smart and scary book."--Rickie Solinger, coauthor, Reproductive Justice: An Introduction"Fixmer-Oraiz powerfully articulates how reproductive justice and homeland maternity provide scholars and activists the vocabularies and interpretive frameworks to interrogate and disrupt dominant mechanisms that are used to police individuals' reproductive lives. Homeland Maternity is intellectually rigorous, forceful, and timely to the current sociopolitical context. It can and should inform future studies in rhetoric, media studies, and gender and women's studies." --Women's Studies in Communication"In this clearly written and cogently argued book that ranges across a broad array of public discourse, Natalie Fixmer-Oraiz brings into focus the disturbing intersections between reproductive politics and national security in the post-9/11 era. Historically and theoretically informed, Homeland Maternity makes clear that the regulation of women's bodies is a key weapon in struggles over nationalism, nativism, and the meaning of security."--Bonnie J. Dow, author of Watching Women's Liberation, 1970: Feminism's Pivotal Year on the Network News"Decidedly grounded in an ethic of reproductive justice and its bringing together of 'feminist studies of maternal and reproductive politics and critical scholarship on homeland security culture,' (3-4) Natalie's homeland maternity provides a necessary and nuanced framework for naming and understanding complex, urgent events around reproductive politics today." --IZG OnZeit"A must-read for scholars interested in contemporary motherhood and/or the rhetoric of security. In Homeland Maternity, Fixmer-Oraiz offers an incisive analysis of an eclectic set of texts to illuminate how the long-standing connections between discursive"This book is devastatingly good. Good because it is elegantly written, tightly argued, and theoretically informed and informative. Devastating because it makes clear that a nasty thicket of laws, institutions, and rhetoric values pregnancy (even a potential pregnancy) more than the integrity, safety, and humanity of women, pregnant people, and mothers. I have long followed public policy debates over reproductive health care. Fixmer-Oraiz's conclusions should not have surprised me and the examples should not have horrified me. But they did." --Argumentation and Advocacy

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Book SynopsisTrade Review"Bhatia, a feminist reproductive justice activist and scholar (SUNY Albany), does not shy away from the difficult issues facing those determined to provide a full range of reproductive options to women of all ethnicities and economic levels. Her account is nuanced, engrossing, and accessible to students and professionals alike. . . . Highly recommended." * Choice *

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Book SynopsisThe authors of this text critically review the psychoanalytic literature on human development and provide an original developmental theory, one that examines psychosexual development in the context of other simultaneously evolving systems - emotional, behavioural, cognitive and social.

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Book SynopsisTable of ContentsCHAPTER 1 INTRODUCTION TO THE ENDOCRINE SYSTEM Objectives Chemical Nature of Hormones Transport of Hormones in the Circulation Cellular Responses to Hormones Summary Self-study Problems Keywords and Concepts CHAPTER 2 ENDOCRINE FUNCTION OF THE GASTROINTESTINAL TRACT 27 Objectives Enteroendocrine Hormone Families and Their Receptors Gastrin and the Regulation of Gastric Function Enteroendocrine Regulation of the Exocrine Pancreas and Gallbladder Insulinotropic Actions of Gastrointestinal Peptides (Incretin Action) Enterotropic Actions of Gastrointestinal Hormones Summary Self-study Problems Keywords and Concepts CHAPTER 3 ENERGY METABOLISM Key Pathways Involved in Energy Metabolism Objectives Overview of Energy Metabolism General Pathways Involved in Energy Metabolism Key Hormones Involved in Metabolic Homeostasis Metabolic Homeostasis: The Integrated Outcome of Hormonal and Substrate/Product Regulation of Metabolic Pathways Liver Skeletal Muscle Adipose Tissue-Derived Hormones and Adipokines Appetite Control and Obesity Diabetes Mellitus Summary Self-study Problems Keywords and Concepts CHAPTER 4 CALCIUM AND PHOSPHATE HOMEOSTASIS Objectives Calcium and Phosphorus are Important Dietary Elements that Play Many Crucial Roles in Cellular Physiology Physiologic Regulation of Calcium and Phosphate: Parathyroid Hormone and 1,25-Dihydroxyvitamin D Small Intestine, Bone, and Kidney Determine Ca2þ and Pi Levels Pathologic Disorders of Calcium and Phosphate Balance Summary Self-study Problems Keywords and Concepts CHAPTER 5 HYPOTHALAMUS-PITUITARY COMPLEX. Objectives Embryology and Anatomy Neurohypophysis Adenohypophysis Summary Self-study Problems Keywords and Concepts CHAPTER 6 THE THYROID GLAND Objectives Anatomy and Histology of the Thyroid Gland Production of Thyroid Hormones Transport and Metabolism of Thyroid Hormones Summary Self-study Problems Keywords and Concepts CHAPTER 7 THE ADRENAL GLAND Objectives Anatomy Adrenal Medulla Adrenal Cortex Zona Glomerulosa Pathologic Conditions Involving the Adrenal Cortex Summary Self-study Problems Keywords and Concepts 176.e1 CHAPTER 8 LIFE CYCLE OF THE MALE AND FEMALE REPRODUCTIVE SYSTEMS Objectives General Components of a Reproductive System Overview of Meiosis Basic Anatomy of the Reproductive Systems Sexual Development in Utero Puberty Menopause and Andropause Summary Self-study Problems Keywords and Concepts 193.e1 CHAPTER 9 THE MALE REPRODUCTIVE SYSTEM Objectives Histophysiology of the Testis Transport, Actions, and Metabolism of Androgens Hypothalamus-Pituitary-Testis Axis Male Reproductive Tract Disorders Involving the Male Reproductive System Summary Self-study Problems Keywords and Concepts 213.e1 CHAPTER 10 THE FEMALE REPRODUCTIVE SYSTEM Objectives Anatomy and Histology of the Ovary Growth, Development, and Function of the Ovarian Follicle The Human Menstrual Cycle Female Reproductive Tract Biology of Estradiol and Progesterone Ovarian Pathophysiology Summary Self-study Problems Keywords and Concepts 238.e1 CHAPTER 11 FERTILIZATION, PREGNANCY, AND LACTATION Objectives Fertilization, Early Embryogenesis, Implantation, and Placentation Placental Transport The Fetal Endocrine System Maternal Endocrine Changes During Pregnancy Maternal Physiologic Changes During Pregnancy Parturition Mammogenesis and Lactation Contraception In Vitro Fertilization Summary Self-study Problems Keywords and Concepts APPENDIX A: ANSWERS TO SELF-STUDY PROBLEMS . APPENDIX B: COMPREHENSIVE MULTIPLE-CHOICE EXAMINATION APPENDIX C: HORMONE RANGES APPENDIX D: ABBREVIATIONS AND SYMBOLS INDEX

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Book SynopsisTable of ContentsSection I. General Section II. Toxicity Testing Models, Safety Evaluation, and Regulatory Aspect Section III. Nanoparticles and Radiation Section IV. Gases and Solvents Section V. Drugs of Abuse and Addiction, Smoking, and Alcohol Section VIII. Pesticides, Industrial, and Other Environmental Contaminants Section IX. Phytotoxicants and Mycotoxins Section X. Special Topics Section XI. Endocrine Disruption Section XII. Infertility and Teratogenicity Section XIII. Toxicologic Pathology Section XIV. Placental Toxicity Section XV. Domestic and Wildlife Species

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Book SynopsisThis new edition of an acclaimed text reviews the evidence for best practice in Maternal-Fetal Medicine, to present the reader with the right information, with appropriate use of proven interventions and avoidance of ineffectual or harmful ones. The information is presented in the right format by summarizing evidence succinctly and clearly in tables and algorithms. The aim is to inform the clinician, to reduce errors and to make it easy to do it right.The volume can be purchased separately or together with the companion volume on Obstetric Evidence Based Guidelines (set ISBN 9780367567033).The Series in Maternal-Fetal Medicine is published in conjunction with the Journal of Maternal-Fetal and Neonatal Medicine.From reviews of previous editions:An excellent resource with quick and easy protocols this book has a permanent spot on my shelf. Doody's Review ServiceTrade Review"An excellent resource with quick and easy protocols… this book has a permanent spot on my shelf."- Doody’s Review Service"...a welcome resource for practicing physicians who need quick access to reliable evidence-based guidelines".- Doody’s Review ServiceTable of ContentsIntroduction. How to “Read” this book. List of Abbreviations. List of Contributors. 1.Hypertensive disorders. 2.Cardiac disease. 3.Obesity. 4.Pregestational diabetes. 5.Gestational diabetes. 6.Hypothyroidism. 7.Hyperthyroidism. 8.Prolactinoma. 9.Nausea/vomiting of pregnancy and hyperemesis gravidarum. 10.Intrahepatic cholestasis of pregnancy. 11.Inflammatory bowel disease. 12.Alimentary tract diseases. 13.Pregnancy after liver and other transplantation. 14.Maternal anemia. 15.Sickle cell disease. 16.von Willebrand Disease. 17.Urinary tract disease. 18.Headache. 19.Seizures. 20.Other neurologic diseases in pregnancy. 21.Mood disorders. 22.Smoking. 23.Substance use disorders. 24.Intimate partner violence and trauma informed care in pregnancy. 25.Racism and racial disparity in obstetrics. 26.Respiratory diseases: asthma, pneumonia, influenza, tuberculosis, and COVID-19. 27.Systemic lupus erythematosus. 28.Antiphospholipid syndrome. 29.Inherited thrombophilia. 30.Venous thromboembolism and anticoagulation. 31.Hepatitis A. 32.Hepatitis B. 33.Hepatitis C. 34.HIV. 35.Gonorrhea. 36.Chlamydia. 37.Syphilis. 38.Trichomonas. 39.Group B Streptococcus. 40.Vaccination. 41.Trauma. 42.Critical care. 43.Amniotic fluid embolism. 44.Cancer. 45.Dermatoses of pregnancy. 46.Multiple gestations. 47.Fetal Growth Restriction. 48.Fetal macrosomia. 49.Cytomegalovirus. 50.Toxoplasmosis. 51.Parvovirus. 52.Herpes. 53.Varicella. 54.Fetal and neonatal alloimmune thrombocytopenia. 55.Hemolytic Disease of the Fetus and Newborn (HDFN). 56.Nonimmune hydrops fetalis. 57.Fetal death. 58.Antepartum testing. 59.Sonographic assessment of amniotic fluid: oligohydramnios and polyhydramnios. Index.

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Book SynopsisThe first edition of The Endometrium was a landmark publishing event in reproductive biology and medicine. Many important developments have occurred in the field, and this new edition has been substantially updated and expanded to include new topics with an improved format. With the addition of several new authors and topics, the Second Edition of The Endometrium has developed new coverage of transcriptomics, stem cells, genetics and in-utero programming. Other new areas strengthen to include: placentology in human and animal models, taking account of the tremendous current interest in the maternal-fetal interface and its role in pregnancy pathology, neonatal and adult health. The layout has also been improved in order to aid browsing and cross-referencing.This is an invaluable up-to-date innovative text that will appeal to a worldwide spectrum of academic and professional readers including postgraduate and postdoctoral researchers in reproductive biologyTrade Review"an impressive international list of authoritative authors who are leaders in their respective fields ... a unique reference tool for students and investigators"- Journal of Fertility & Sterility, about the previous editionTable of ContentsList of Contributors. Preface to the First Edition. Preface to the Second Edition. Color Plates. Section I: Development. 1. Embryology of the Uterus. 2. Puberty, Menarche and the Endometrium. Section II: Mature Female Reproductive Tract. 3. Menstrual and Estrous Cycles. 4. The Fine Structure of the Mature Human Endometrium. 5. The Cytoskeleton of Uterine Epithelial and Stromal Cells. 6. Endometrial Angiogenesis, Arteriogenesis, and Lymphangiogenesis. 7. Endometrial Imaging. 8. Estrogen and Progesterone Regulation of Cell Proliferation in the Endometrium of Muridae and Humans. 9. Progesterone Antagonists and the Non-Human Primate Endometrium. Section III: Regulatory Biology. 10. Endometrial Stem Cells. 11. Transgenic Models of Uterine Biology. 12. Estrogen-Regulated Genes in the Endometrium. 13. Progesterone-Regulated Genes in the Endometrium. 14. Transcriptomics. 15. Paracrine Mediators of Endometrial Growth and Differentiation. 16. A Comparative View of Prostaglandin Action in the Uterus. Section IV: Establishment of Pregnancy. 17. Maternal Recognition of Pregnancy. 18. Chorionic Gonadotropin Signaling at the Maternal–Fetal Interface. 19. Embryo–Endometrial Signaling. 20. Endometrial Receptivity. 21. Connexins: Indicators for Hormonal and Blastocyst-Mediated Endometrial Differentiation. 22. Blastocyst Implantation: The Adhesion Cascade. 23. The Prolactin Family: Regulators of Uterine Biology. Section V: The Endometrial Stroma. 24. Endometrial Extracellular Matrix. 25. Signaling and Transcription Factor Networks in the Human Endometrial Stroma. 26. Human Endometrial Hemostasis During the Menstrual Cycle and Gestation. 27. Uterine Stromal Cell Differentiation in Non-Decidualizing Species. Section VI: Placentation. 28a. Implantation of the Blastocyst: I. Comparative Studies. 28b. Implantation of the Blastocyst: II. Implantation in Primates. 29. Human Placental Development. 30. Differentiation of the Invasive Cytotrophoblast Lineage in Normal Pregnancy and in Preeclampsia. 31. Mechanisms of Trophoblast Differentiation and Maternal–Fetal Interactions in the Mouse. 32. Epitheliochorial and Endotheliochorial Placentas. Section VII: Immunobiology. 33. Innate and Adaptive Immunity in the Human Female Reproductive Tract: Influence of the Menstrual Cycle and Menopause on the Mucosal Immune System in the Uterus. 34. Molecular Immunology of the Maternal–Fetal Interface. 35. Cytokine and Chemokine Regulation of Endometrial Immunobiology. 36. Endometrial Complement: Physiology and Pathophysiology. Section VIII: Pharmacological Models and Gene Therapy. 37. Endometrial Paradigms. 38. Endometrial Effects of Hormonal Contraception. 39. Endometrial Effects of Selective Progesterone Receptor Modulators. 40. In-Utero Gene Transfer: Promises and Problems. Section IX: Assisted Reproductive Technology. 41. Gamete Quality and Assisted Reproductive Technologies. 42. Unanswered Questions and Proposed Solutions in Assisted Reproductive Technologies. 43. Clinical Relevance of Endometrial Assessment. 44. Reproductive Freedom and Access to Assisted Reproductive Technologies. Section X: Pathology and Therapy. 45. The Endometrium of Polycystic Ovary Syndrome. 46. Endometriosis. 47. The Pathophysiology of Dysfunctional Uterine Bleeding. 48. Colonization and Infection of the Endometrium. 49. Ectopic Pregnancy. 50. Preeclampsia and Intrauterine Growth Restriction. 51. Aging of the Endometrium. 52. The Effects of Hormone Therapy and Botanicals and Dietary Supplements on the Endometrium. 53. Uterine Disease in Midlife and Beyond: The Menopausal Transition and Postmenopause. 54. Benign Uterine Disease: Leiomyomata and Benign Polyps. 55. Models of Endometrial Carcinogenesis. 56. Malignancy.

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Book SynopsisA new subspecialty is growing at the interface of reproductive medicine and perinatology: infertility. Textbook of Periconceptional Medicine provides an authoritative and comprehensive reference resource for those providing medical care to women trying to conceive a healthy pregnancy.A revolutionary first edition, this text brings together a number of difficult and usually separate topics and provides the busy clinician with one authoritative and methodical reference.Reflecting the breadth of modern clinical practice in this emerging therapy area, this integrated text incorporates aspects of all the relevant existing expertise, including: Preconceptual counseling Fertility investigation Therapy and management of preconception through the first trimester of pregnancy Table of ContentsPRECONCEPTION 1. Genetics and Conception 2. Lifestyle and Conception 3. Preconceptual Counselling PREPARING THE HIGH-RISK PATIENT 4. The Patient with Renal Disease 5. The Patient with an Organ Transplant 6. The Patient with Hypertension 7. The Patient with Cardiac Disease 8. The Patient with Thyroid Disease 9. The Patient with Diabetes 10. The Patient with Epilepsy 11. The Patient with Thrombosis and Bleeding Disorders 12. The Patient with Polycystic Ovary Syndrome 13. The Patient with HIV 14. The Patient with Cystic Fibrosis 15. The Patient with Inflammatory Bowel Disease 16. The Patient with Prolactinoma 17. Periconceptional Issues in Neuromuscular Disorders. 18. The Patient with or at Risk of Severe Mental Illness ACHIEVING PREGNANCY 19. How to Conceive: Evidence Based Fertility Investigation 20. The Anovulatory Patient 21. The Patient with Endometriosis 22. The Patient with Poor Sperm Quality 23. The Patient with Tubal Disease 24. The Couple with Unexplained Infertility 25. The Patient from the Developing World 26. Older Woman Wishing to Conceive 27. Psychological Aspects of Fertility Therapy 28. The Luteal Phase 29. Implantation Failure MANAGEMENT OF EARLY PREGNANCY 30. Early Placental Development 31. The Immunology of Early Pregnancy 32. Mechanisms and Nomenclature of Early Pregnancy Loss 33. Antiphospholipid Syndrome, Heritable Thrombophilia and Early Pregnancy Loss 34. Ultrasound in Early Pregnancy 35. Evidence Based Investigation and Management of Miscarriage 36. Ectopic Pregnancy after Fertility Treatment 37. Molar Pregnancy 38. Multiple Pregnancy 39. Cervical Cerclage and Pregnancy Loss 40. The IVF Pregnancy: High Risk Management?

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Book SynopsisThis volume focuses on practical strategies for assessing and managing occupational reproductive risk, which are highlighted in numerous case studies. It covers the basics of reproductive and developmental biology, risk assessment and workplace risk reduction.Table of ContentsPartial table of contents: FRAMEWORK FOR REPRODUCTIVE HAZARD MANAGEMENT. Normal Reproductive and Developmental Biology (M. Hage & L. Frazier). Reproductive and Developmental Risk Assessment (D. Mattison). Reproductive Risk Reduction in the Workplace (L. Frazier & G. Stave). CHEMICAL AGENTS. Metals (R. Sokas). Solvents (D. Darcey & R. Langley). Pesticides (K. Filkins). Disinfectants (L. Frazier). Pharmaceuticals (V. Weaver & V. Dailey). Carcinogens and Mutagens (R. Tippens & W. Stopford). PHYSICAL AGENTS. Noise, Ultrasound, and Vibration (G. Greenberg, et al.)). OCCUPATIONAL FACTORS. Infectious Agents and Noninfectious Biologic Products (E. Livingston). Domestic and Foreign Travel (J. Young & M. Hage). Appendices. Index.

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Book SynopsisThis book provides a scientific rationale on managing pregnancies complicated by diabetes and offers recommendations on which clinical practice can be based. It discusses all aspects of basic science and health care.Table of ContentsPartial table of contents: Diabetes in Pregnancy: Past, Present and Future (D. Hadden). PATHOPHYSIOLOGY. The Metabolic Stress of Pregnancy (T. Buchanan & A.Dornhorst). PREGNANCY. Insulin Therapy in Diabetic Pregnancy (R. Firth). Monitoring Fetal Well-Being in Diabetic Pregnancy (J.Girling). CHILDBIRTH. Labour and Delivery (J. Oats). LONG-TERM IMPLICATIONS OF A DIABETIC PREGNANCY. Contraception and Future Pregnancies (H. Morgan). Prevention of Diabetes Following Gestational Diabetes (M. Rossi& A. Dornhorst). The Perspective of a Mother with Diabetes (H. Blanchard). Epilogue: The Way Forward (J. Hoet). Index.

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Book SynopsisAn inclusive women's health guide to menopause and beyond from female GP, women's health specialist, broadcaster and advocate for underserved communities Dr Nighat Arif ITV This Morning's GP Dr Nighat Arif  brings you the essential guide to perimenopause, menopause and beyond. This book tackles important topics including: - Perimenopausal symptoms such as bladder irritation, vaginal atrophy, headaches and hot flashes - How to relieve symptoms, including lifestyle changes and hormone replacement therapy (HRT) - Understanding the risk of breast cancer and how to spot it - Guidance for discussing menopause and championing your symptoms with your doctorThe Knowledge: Menopause and Beyond encompasses all experiences, including the perspectives of women of color, people of all cultures, and the transgender community to ensure that all groups affected by female health concerns are a part of vital conversations. For all women and people assigned female at birth, whether you are dealing with uncomfortable symptoms of menopause or concerned about signs of breast cancer, this book will guide you through it.

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Book SynopsisTrade Review"[Dow's] musings about dong anthropological fieldwork in Spey Bay add a layer of brilliant reflexivity to her scholarly account."--Barbara J. King, Times Literary SupplementTable of ContentsAcknowledgements ix Prologue: The Sperm Whale's Teeth 1 Introduction: Life in a Nature Reserve 7 // Where the River Meets the Sea 50 1 Ethical Labour 55 // Beginnings 81 2 Future Generations 83 // The Water of Life 103 3 Origin Stories 107 // Arrivals 129 4 Ties That Bind 134 // The Sperm Whale's Teeth Revisited 161 5 Money Talks 164 // You've Been Trumped! 184 6 A Stable Environment 187 Notes 201 Bibliography 217 Index 229

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Book SynopsisTrade Review"[Dow's] musings about dong anthropological fieldwork in Spey Bay add a layer of brilliant reflexivity to her scholarly account."--Barbara J. King, Times Literary SupplementTable of ContentsAcknowledgements ix Prologue: The Sperm Whale's Teeth 1 Introduction: Life in a Nature Reserve 7 // Where the River Meets the Sea 50 1 Ethical Labour 55 // Beginnings 81 2 Future Generations 83 // The Water of Life 103 3 Origin Stories 107 // Arrivals 129 4 Ties That Bind 134 // The Sperm Whale's Teeth Revisited 161 5 Money Talks 164 // You've Been Trumped! 184 6 A Stable Environment 187 Notes 201 Bibliography 217 Index 229

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Book SynopsisTrade Review"This book is frankly opinionated, though far from close-minded, and joins analytic arguments with appeals to sensibility... Time and again, Purdy points out double standards, juxtaposing the ways in which we frame and judge women's behavior with the ways in which we frame and judge behavior elsewhere." -- Margaret Olivia Little, Kennedy Institute of Ethics, Women and Health

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Book SynopsisSarah Franklin explores the history and future of in vitro fertilization (IVF) thirty-five years and five million babies after its initial success as a form of technologically-assisted human reproduction.Trade Review"A model of what interdisciplinary intelligence can accomplish. Across several fields Biological Relatives shows how specific platforms or tools in the history of reproduction, kinship, and gender have provided discursive liftoff for further sites of knowledge and exploration. One of the strengths of this gripping account lies in that specificity, beginning with the iconic IVF and its epistemic work: a brilliant and exhilarating reprise of what we thought we knew, but now know differently."—Marilyn Strathern, University of Cambridge"Hurtled with eggs, sperm, embryos, technicians, scientists, photographers, and critters of many species, including humans, we are all redone by the histories and practices of IVF. Sarah Franklin makes vivid how IVF is a kin-making, person-making, and world-making engine, one that refabricates the facts of life into bundles of kin and bundles of kin into facts of life. No wonder I read Biological Relatives as a fabulous work of SF in all its tones—string figures, speculative fabulation, science fact. Because Franklin's multigeneric gifts are generous, my debts are large."—Donna Haraway, University of California, Santa Cruz"[A] well-researched, conceptually rigorous, and thoroughly interdisciplinary discussion of new reproductive technologies. . . . This cutting-edge volume is essential for scholars and practitioners interested in the ethics of reproductive technologies, technology theory case studies, sex/gender reinforcing and challenging practices, and medical humanities in general. . . . Highly recommended. Upper division undergraduates and above." -- S. M. Weiss * Choice *“Being well informed about these areas of contemporary biology requires familiarity with both natural and social sciences. Sarah Franklin’s Biological Relatives provides a much-needed account of one such area…. Her range is wide, but her examples are precise and disciplined. Reading the book illuminates ways to see across divides, and there are some striking images along the way.” -- Charis Thompson * Science Magazine *“Biological Relatives presents a complex examination of a topic that has been too often simplified or fragmented and provides feminist scholars of science with a new framework through which to analyze the relationship between biology and technology in a post-IVF age. . . . The book’s willingness to dwell with the many ambiguities of IVF—what Franklin refers to as its ‘curious’ elements—thus makes an important contribution to our understanding of what it means to live in a post-IVF age.” -- Sara DiCaglio * Configurations *“Biological Relatives goes far beyond earlier studies to provide new and valuable insight into the history of IVF. These include new perspectives on both complex evolutionary processes of biology and the overall historical descriptions about feminist debates over IVF in connection with the notion of kinship and women’s actual voices. Finally, Franklin successfully cultivates a novel and constructive account of the dynamics, complexity and hybridity in the history of IVF in connection with related science fields and social and cultural areas.” -- Kaori Sasak * Medical History *“Franklin’s rigorously researched and exhaustive look at ‘the normalization of I.V.F.’ grounds the procedure firmly in technology and science, not to mention philosophy, anthropology, agriculture, feminism, and history.” -- Sarah Erdreich * Lilith *"Biological Relatives would fit well in advanced undergraduate courses in medical anthropology and sociology, gender and reproduction, feminist theory, and social theories of technology. It will also be invaluable in graduate coursework across a variety of disciplines, including anthropology, sociology, feminist studies, and science and technology studies, as well as for researchers and clinicians who work at the perpetually unstable frontiers of reproduction, bioinnovation, and kinship." -- Crista Craven & Thomas Tierney * American Ethnologist *“Not since Donna J. Haraway’s 1997 book, Modest_Witness@Second_Millennium.FemaleMan©Meets_OncoMouse™ have I read such a major contribution to theorizing technoscience. … The book leaves us with a cultural rendering and an archeology of a technology, from the ambivalent relations with its form as a reproductive technology to the many ways that IVF is also a tool itself in the coevolving biotech industries. IVF is not only biologically reproductive, but also technologically reproductive. This book should be read by anyone interested in theorizing biotechnology and the future of social relations.” -- Laura Mamo * American Journal of Sociology *“Biological Relatives amounts to an impressive and important exploration of the curious world, effects, and various 'lives' of IVF. It is a book that dares to be multidimensional and non-reductionist, and which shows the complexity of relationships, biological and technological as well as familial. … [A] much-needed, important, and sensitive analysis of IVF and the changed relationships it introduces to biology, technology, and kinship.” -- Petra Nordqvist * Technology and Culture *[T]his exciting book delivers a powerful theory of biology and technology that challenges scholars of Science and Technology Studies, the anthropology of kinship, and gender and feminist theory to consider and respond. It will be a must-read for any scholar of IVF,synthetic biology, the anthropology of science and nature, or gender studies.” -- Ian Vincent McGonigle * Journal of the Royal Anthropological Institute *Table of ContentsAcknowledgments ix Introduction. Relatively Biological 1 1. Miracle Babies 31 2. Living Tools 68 3. Embryo Pioneers 102 4. Reproductive Technologies 150 5. Living IVF 185 6. IVF Live 221 7. Frontier Culture 258 8. After IVF 297 Afterword 311 Notes 313 References 333 Index 351

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Book SynopsisSarah Franklin explores the history and future of in vitro fertilization (IVF) thirty-five years and five million babies after its initial success as a form of technologically-assisted human reproduction.Trade Review"A model of what interdisciplinary intelligence can accomplish. Across several fields Biological Relatives shows how specific platforms or tools in the history of reproduction, kinship, and gender have provided discursive liftoff for further sites of knowledge and exploration. One of the strengths of this gripping account lies in that specificity, beginning with the iconic IVF and its epistemic work: a brilliant and exhilarating reprise of what we thought we knew, but now know differently."—Marilyn Strathern, University of Cambridge"Hurtled with eggs, sperm, embryos, technicians, scientists, photographers, and critters of many species, including humans, we are all redone by the histories and practices of IVF. Sarah Franklin makes vivid how IVF is a kin-making, person-making, and world-making engine, one that refabricates the facts of life into bundles of kin and bundles of kin into facts of life. No wonder I read Biological Relatives as a fabulous work of SF in all its tones—string figures, speculative fabulation, science fact. Because Franklin's multigeneric gifts are generous, my debts are large."—Donna Haraway, University of California, Santa Cruz"[A] well-researched, conceptually rigorous, and thoroughly interdisciplinary discussion of new reproductive technologies. . . . This cutting-edge volume is essential for scholars and practitioners interested in the ethics of reproductive technologies, technology theory case studies, sex/gender reinforcing and challenging practices, and medical humanities in general. . . . Highly recommended. Upper division undergraduates and above." -- S. M. Weiss * Choice *“Being well informed about these areas of contemporary biology requires familiarity with both natural and social sciences. Sarah Franklin’s Biological Relatives provides a much-needed account of one such area…. Her range is wide, but her examples are precise and disciplined. Reading the book illuminates ways to see across divides, and there are some striking images along the way.” -- Charis Thompson * Science Magazine *“Biological Relatives presents a complex examination of a topic that has been too often simplified or fragmented and provides feminist scholars of science with a new framework through which to analyze the relationship between biology and technology in a post-IVF age. . . . The book’s willingness to dwell with the many ambiguities of IVF—what Franklin refers to as its ‘curious’ elements—thus makes an important contribution to our understanding of what it means to live in a post-IVF age.” -- Sara DiCaglio * Configurations *“Biological Relatives goes far beyond earlier studies to provide new and valuable insight into the history of IVF. These include new perspectives on both complex evolutionary processes of biology and the overall historical descriptions about feminist debates over IVF in connection with the notion of kinship and women’s actual voices. Finally, Franklin successfully cultivates a novel and constructive account of the dynamics, complexity and hybridity in the history of IVF in connection with related science fields and social and cultural areas.” -- Kaori Sasak * Medical History *“Franklin’s rigorously researched and exhaustive look at ‘the normalization of I.V.F.’ grounds the procedure firmly in technology and science, not to mention philosophy, anthropology, agriculture, feminism, and history.” -- Sarah Erdreich * Lilith *"Biological Relatives would fit well in advanced undergraduate courses in medical anthropology and sociology, gender and reproduction, feminist theory, and social theories of technology. It will also be invaluable in graduate coursework across a variety of disciplines, including anthropology, sociology, feminist studies, and science and technology studies, as well as for researchers and clinicians who work at the perpetually unstable frontiers of reproduction, bioinnovation, and kinship." -- Crista Craven & Thomas Tierney * American Ethnologist *“Not since Donna J. Haraway’s 1997 book, Modest_Witness@Second_Millennium.FemaleMan©Meets_OncoMouse™ have I read such a major contribution to theorizing technoscience. … The book leaves us with a cultural rendering and an archeology of a technology, from the ambivalent relations with its form as a reproductive technology to the many ways that IVF is also a tool itself in the coevolving biotech industries. IVF is not only biologically reproductive, but also technologically reproductive. This book should be read by anyone interested in theorizing biotechnology and the future of social relations.” -- Laura Mamo * American Journal of Sociology *“Biological Relatives amounts to an impressive and important exploration of the curious world, effects, and various 'lives' of IVF. It is a book that dares to be multidimensional and non-reductionist, and which shows the complexity of relationships, biological and technological as well as familial. … [A] much-needed, important, and sensitive analysis of IVF and the changed relationships it introduces to biology, technology, and kinship.” -- Petra Nordqvist * Technology and Culture *[T]his exciting book delivers a powerful theory of biology and technology that challenges scholars of Science and Technology Studies, the anthropology of kinship, and gender and feminist theory to consider and respond. It will be a must-read for any scholar of IVF,synthetic biology, the anthropology of science and nature, or gender studies.” -- Ian Vincent McGonigle * Journal of the Royal Anthropological Institute *Table of ContentsAcknowledgments ix Introduction. Relatively Biological 1 1. Miracle Babies 31 2. Living Tools 68 3. Embryo Pioneers 102 4. Reproductive Technologies 150 5. Living IVF 185 6. IVF Live 221 7. Frontier Culture 258 8. After IVF 297 Afterword 311 Notes 313 References 333 Index 351

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Book SynopsisMarcia C. Inhorn's ethnography of international travelers seeking in vitro fertilization treatment in the global IVF hub of Dubai shows that infertile couples, or "reprotravelers," leave their countries because IVF treatment is not safe, affordable, legal or effective. Inhorn opens a window into the painful, frustrating, and expensive world of infertility.Trade Review"Cosmopolitan Conceptions offers a fresh and much needed perspective on global infertility.... This book is a crucial read for those interested in the politics of reproduction, parenthood, kinship, globalization, the use of technologies, modernization, and the Middle East.... Inhorn has created a provocative account of infertile couples’ quests for a child, which not only contributes to scholarly discussions, but also to public debates about infertility and treatment and the global movement of knowledge and technologies." -- Cortney Hughes Rinker * Middle East Journal *"This book truly does take the reader into the 'womb' of a cosmopolitan IVF clinic and the reprotravelers who are its clientele. It is a must read for students of anthropology, medicine, women’s history, whether or not they are involved in research on human reproduction. This is a must read for NGOs, ministries of health, medical practitioners, and others who are deeply committed, particularly in noncosmopolitan states, to working for the improvement of women’s maternal and reproductive health. I highly recommend this enlightening, ethnographically rich and deeply compassionate book." -- Naomi M. McPherson * Anthropology Book Forum *"This outstanding and readable book is equally valuable for interdisciplinary scholars, global reproductive justice advocates, and infertility caregivers." -- Laury Oaks * American Anthropologist *"What strikes me most, as an anthropologist also engaged in the uphill struggle of tracing varied global reproductive travel routes, is Inhorn’s uncanny ability to truly engage with her informants. She embodies the cultural cosmopolitanism of which she writes. Her empathic nature and ability to speak with couples from all over the world reveals her skills of engaging with people—the heart of the anthropological endeavor." -- Amy Speier * Medical Anthropology Quarterly *"This well-written and powerful book can and should be read by a wide audience." -- Susie Kilshaw * Journal of International and Global Studies *"Inhorn has a sure grasp on global infertility issues and uses her rich empirical data to argue for better, and fairer, provision of ARTs across the world.... The great strength of Cosmopolitan Conceptions is Inhorn’s ability to give voice to her informants." -- Katharine Dow * Journal of the Royal Anthropological Institute *Table of ContentsIllustrations ix Prologue. Rahnia's Reproductive Journey xi Introduction. IVF Sojourns 1 1. Hubs: Medical Cosmopolitanism in the Emirates 35 Hubs: Reprotravel Stories 77 2. Absences: Resource Shortages and Waiting Lists 105 Absences: Reprotravel Stories 138 3. Restrictions: Religious Bans and Law Evasion 159 Restricitions: Reprotravel Stories 197 4. Discomforts: Medical Harm and the Search for High-Quality IVF 221 Discomforts: Reprotravel Stories 255 Conclusion. Cosmopolitan Conceptions 287 Acknowledgments 305 Glossory of Medical Terms 311 Notes 321 References 351 Index 371

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Book SynopsisMarcia C. Inhorn's ethnography of international travelers seeking in vitro fertilization treatment in the global IVF hub of Dubai shows that infertile couples, or "reprotravelers," leave their countries because IVF treatment is not safe, affordable, legal or effective. Inhorn opens a window into the painful, frustrating, and expensive world of infertility.Trade Review"Cosmopolitan Conceptions offers a fresh and much needed perspective on global infertility.... This book is a crucial read for those interested in the politics of reproduction, parenthood, kinship, globalization, the use of technologies, modernization, and the Middle East.... Inhorn has created a provocative account of infertile couples’ quests for a child, which not only contributes to scholarly discussions, but also to public debates about infertility and treatment and the global movement of knowledge and technologies." -- Cortney Hughes Rinker * Middle East Journal *"This book truly does take the reader into the 'womb' of a cosmopolitan IVF clinic and the reprotravelers who are its clientele. It is a must read for students of anthropology, medicine, women’s history, whether or not they are involved in research on human reproduction. This is a must read for NGOs, ministries of health, medical practitioners, and others who are deeply committed, particularly in noncosmopolitan states, to working for the improvement of women’s maternal and reproductive health. I highly recommend this enlightening, ethnographically rich and deeply compassionate book." -- Naomi M. McPherson * Anthropology Book Forum *"This outstanding and readable book is equally valuable for interdisciplinary scholars, global reproductive justice advocates, and infertility caregivers." -- Laury Oaks * American Anthropologist *"What strikes me most, as an anthropologist also engaged in the uphill struggle of tracing varied global reproductive travel routes, is Inhorn’s uncanny ability to truly engage with her informants. She embodies the cultural cosmopolitanism of which she writes. Her empathic nature and ability to speak with couples from all over the world reveals her skills of engaging with people—the heart of the anthropological endeavor." -- Amy Speier * Medical Anthropology Quarterly *"This well-written and powerful book can and should be read by a wide audience." -- Susie Kilshaw * Journal of International and Global Studies *"Inhorn has a sure grasp on global infertility issues and uses her rich empirical data to argue for better, and fairer, provision of ARTs across the world.... The great strength of Cosmopolitan Conceptions is Inhorn’s ability to give voice to her informants." -- Katharine Dow * Journal of the Royal Anthropological Institute *Table of ContentsIllustrations ix Prologue. Rahnia's Reproductive Journey xi Introduction. IVF Sojourns 1 1. Hubs: Medical Cosmopolitanism in the Emirates 35 Hubs: Reprotravel Stories 77 2. Absences: Resource Shortages and Waiting Lists 105 Absences: Reprotravel Stories 138 3. Restrictions: Religious Bans and Law Evasion 159 Restricitions: Reprotravel Stories 197 4. Discomforts: Medical Harm and the Search for High-Quality IVF 221 Discomforts: Reprotravel Stories 255 Conclusion. Cosmopolitan Conceptions 287 Acknowledgments 305 Glossory of Medical Terms 311 Notes 321 References 351 Index 371

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Book SynopsisUsing deconstruction, this book approaches contemporary problems raised by technologies of life and death from cloning to capital punishment; and thereby, provides new insights into current debates from a perspective outside of mainstream philosophy with its assumptions of individual and political sovereignty.Trade Review"In Technologies of Life and Death Kelly Oliver addresses some of the most intractable ethical issues of our day. The relevance of continental philosophy in general and of Derridean deconstruction in particular has rarely been demonstrated with such lucidity." -- -Robert Bernasconi Penn State University "In this creative, fascinating, witty, and remarkably fearless book, Oliver takes on the most important questions of human existence (including the meaning of birth and death and the limits of the human) and reframes them for us in thought-provoking ways." -- -Elissa Marder Emory University

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Book SynopsisUsing deconstruction, this book approaches contemporary problems raised by technologies of life and death from cloning to capital punishment; and thereby, provides new insights into current debates from a perspective outside of mainstream philosophy with its assumptions of individual and political sovereignty.Trade Review"In Technologies of Life and Death Kelly Oliver addresses some of the most intractable ethical issues of our day. The relevance of continental philosophy in general and of Derridean deconstruction in particular has rarely been demonstrated with such lucidity." -- -Robert Bernasconi Penn State University "In this creative, fascinating, witty, and remarkably fearless book, Oliver takes on the most important questions of human existence (including the meaning of birth and death and the limits of the human) and reframes them for us in thought-provoking ways." -- -Elissa Marder Emory University

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Book SynopsisThis comprehensive approach to the diagnosis, investigation, counselling and management of fetal abnormalities and disorders offers practical clinical guidance to decision making. Highly illustrated throughout in an easy-to-read, algorithm format this book is for all maternal-fetal care specialists and allied healthcare professionals in fetal care.Table of Contents1. Fetal anatomy: first trimester assessment; 2. Screening for common chromosomal abnormalities and other genetic conditions; 3. Fetal Anatomy: second and third trimester assessment; 3.1 Head and neck; 3.2 Fetal heart and common antenatally diagnosed cardiac anomalies; 3.3 Thoracic and pulmonary abnormalities; 3.4 Spine; 3.5 Abdomen; 3.6 Genito-urinary tract; 3.7 Skeletal Anomalies; 4. Small for gestational age and fetal growth restriction; 5. Large for gestation age fetus; 6. Rhesus disease; 7. Fetal alloimune Thrombocytopenia; 8. Hydrops in second and third trimester; 9. Abnormal placenta; 10. Umbilical cord abnormalities; 11. Amniotic fluid abnormalities; 12. Multiple pregnancy; 13. Short cervix in asymptomatic women; 14. Fetal infections; 15. Drugs in pregnancy and teratogenesis; 16. Ultrasound guided invasive diagnostic and therapeutic procedures; 17. Fetoscopy and ultrasound guided thermal therapeutic prodecures; 18. Fetal surgery for spina bifida; 19. Genetic syndromes; 20. Termination of pregnancy for fetal abnormality.

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Book SynopsisA handy guide to every method of contraception, helping readers decide what works best for them. Covering how each method works, how to use it correctly and how effective it is, the authors expertly explain how life stage can affect choice, and how hormonal contraception can help other health conditions--Table of ContentsPreface; Introduction; 1. Conception and the menstrual cycle; 2. Making decisions about contraception; 3. Barrier methods of contraception; 4. Combined hormonal contraception: the pill, patch and vaginal ring; 5. Progestogen-only pill (POP) ; 6. Long-acting reversible contraception: implants, injections and intrauterine devices and systems (coils); 7. Fertility awareness methods of contraception; 8. Emergency contraception; 9. Use of hormonal contraception to treat other conditions.

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Book SynopsisFirst published in 1919 as ''Diseases of Women'', Gynaecology by Ten Teachers is well established as a concise, yet comprehensive, guide within its field. The 21st Edition has been thoroughly updated by its latest team of ''teachers'', integrating clinical material with the latest scientific developments that underpin patient care. Each chapter is highly structured, with learning objectives, definitions, aetiology, clinical features, investigations, treatments and key point summaries and additional reading where appropriate. A key theme for this edition is ''professionalism'' and information specific to this is threaded throughout the text. KEY FEATURES Fully revised content is entirely refreshed and up to date for this 21st Edition, including the latest imaging and reproductive technologies and current guidelines for best practices Highly illustrated text supported and enhanced throughout by high-quality colour li

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Book SynopsisEstablished as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on laboratory topics, including KPIs for the IVF laboratory, Quality control in the cloud, Artificial Intelligence, AI in gamete and embryo selection, Demystifying vitrification, Microfluidics, Gene editing, Disaster management, and Early human embryo development revealed by static imaging. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.Table of ContentsPreface. Contributors. Updated Guidelines for Setting up an Assisted Reproductive Technology Laboratory. Quality Control: Maintaining Stability in the Laboratory. KPIs for the IVF Laboratory. QC in the Clouds—Digitizing Quality Control. The Assisted Reproduction Technology Laboratory: Current Standards. Evaluation of Sperm. Sperm Preparation Techniques and Advanced Sperm Selection for Intracytoplasmic Sperm Injection. Sperm Chromatin Assessment. Oocyte Retrieval and Selection. Preparation and Evaluation of Oocytes for Intracytoplasmic Sperm Injection. Use of IVM in a Clinical Setting: What is its Role in ART?. Intracytoplasmic Sperm Injection: Technical Aspects. Human Embryo Biopsy Procedures. Analysis of Fertilization. Culture Systems for the Human Embryo. Embryo Selection through the Analysis of Morphology and Physiology. Evaluation of Embryo Quality: Time-Lapse Imaging to Assess Embryo Morphokinesis. Artificial Intelligence (AI). Artificial Intelligence (AI) in Gamete and Embryo Selection. Demystifying Vitrification. Vitrification of the Human Oocyte. The Human Embryo: Vitrification. Managing an Oocyte Bank. Severe Male Factor Infertility: Genetic Consequences and Recommendations for Genetic Testing. Pre-Implantation Genetic Testing for Aneuploidy to Improve Clinical Outcomes. Diagnosis of Endometrial Receptivity, Embryo–Endometrial Dialogue, and Endometrial Microbiome. Artificial Gametes: Oocytes. How Microfluidics and Microfabrication will Improve Diagnosis and Treatment in Human Art. Genome Editing in Human Reproduction. Designing Disaster Plans for IVF Laboratories. Early Human Embryo Development Revealed by Static Imaging. Index.

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Book SynopsisIn this book, Patricia Alkolombre explores the desire for a child from a contemporary psychoanalytic perspective, and covers the questions raised in the face of new resources offered by reproductive medicine.This volume reviews traditional psychoanalytic conceptualisations from the perspective of gender theories and analyses theoretical hegemonies related to the desire and passion for a child. Alkolombre discusses how the passion to have a child' is a key aspect of motherhood, characterised by emotional intensity, persistence, and self-sacrificial aspects.The book is divided into three sections: Part One deals with the desire and passion to have a child, while Part Two focuses on the impact of reproductive techniques, as well as the ever-changing role of parenthood in the modern day. Throughout these fascinating chapters, clinical vignettes of both individual and couple analyses span topics such as mourning, the use of reproductive technology, the anonymity of gamete dTrade Review'In The Desire and The Passion for a Child, Patricia Alkolombre offers a deep dive into the implications of emerging reproductive technology for our understanding of a potential parent’s relationship to sexuality, the procreative body, and a child’s origin story. She portrays the necessity of mourning female and male infertility, a lost pregnancy, and altered experiences of self and intimate other. This is an important book for the psychoanalytic clinician who enters the contemporary biopsychosocial terrain where desire turns to passion. While new technology supports new family constellations, it also risks the creation of a child at any cost.'Harriet Wolfe, M.D., President, International Psychoanalytical Association'In this excellent book, Patricia Alkolombre offers us a contemporary psychoanalytic approach to current parenting. Clinical, theoretical, and ethical problems of assisted fertilization circulate throughout the text also grasping on the meanings of sterility in women and men. Key issues such as mourning, abortion, bodies, donation of gametes and surrogate maternity are focused framed in a biotechnological offer in vertiginous development. In this complex journey the author differentiates the desire for a child from the passion for a child, the latter as a search for narcissistic gratification that leads some women to resort without limit to assisted fertilization. This volume will enrich readers, whether psychoanalysts or not, interested in this crucial topic.'Leticia Glocer Fiorini M.D., Chair of Sexual and Gender Diversity Studies Committee, International Psychoanalytic Association IPATable of ContentsIntroduction PART I About the desire and the passion for a child 1 Revisiting desire for a child 2 When desire for a child becomes passion for a child PART II Techniques in the light of psychoanalysis 3 Into psychoanalytic clinical work 4 Psychoanalysis and reproductive techniques PART III Historical (in) fertility 5 First conceptions 6 Fertility myths and rituals

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Book SynopsisThe Reproductive System at a Glance is a comprehensive guide to normal reproductive biology and associated pathophysiology in both sexes. Concise, easy to read, and clearly structured, the double-page spreads progress from basic science to clinical abnormalities, and covers endocrine production and action, within one short volume.Chapters on disorders summarise epidemiology, pathophysiology, diagnosis and treatment. This new edition of The Reproductive System at a Glance: Is fully revised and updated throughout to reflect recent developments in practice Now features histological and pathological slides to complement the at a glance style explanatory illustrations Now features radiologic studies to supplement the text in selected chapters Contains more detailed coverage of maternal adaptations to pregnancy Includes a companion website at www.ataglanceseries.com/reproduction featuring self-assessment multiple choice questions, bonus single answer questions and flashcards The Reproductive System at a Glance is an ideal guide for students studying both endocrine and reproductive subjects, and teaches the foundation concepts for the obstetrics and gynaecology rotation, helping health professionals and students achieve a broad and practical understanding of the topic.Table of ContentsPreface 6 Table and figure acknowledgements 7 About the companion website 9 Part 1 Normal human reproduction 1 The pituitary gland and gonadotropins 10 2 Steroid hormone biosynthesis 12 3 Steroid hormone mechanism of action and metabolism 14 4 Reproductive genetics 16 5 Gonadal development in the embryo 18 6 Phenotypic sex differentiation 20 7 Gross anatomy of the male reproductive tract 22 8 Microscopic anatomy of the male reproductive tract 24 9 Gross anatomy of the female reproductive tract 26 10 Microscopic anatomy of the female reproductive tract 28 11 Puberty in boys 30 12 Puberty in girls 32 13 Male reproductive physiology 34 14 The menstrual cycle 36 15 Human sexual response 38 16 Fertilization and the establishment of pregnancy 40 17 Placental structure and function 42 18 The protein hormones of pregnancy 44 19 The steroid hormones of pregnancy 46 20 Maternal adaptations to pregnancy: I 48 21 Maternal adaptations to pregnancy: II 50 22 Labor 52 23 The breast and lactation 54 24 Menopause 56 25 Contraception 58 Part 2 Human reproductive disorders 26 Abnormalities of male sexual differentiation and development 60 27 Abnormalities of female sexual differentiation and development 62 28 Precocious puberty 64 29 Delayed or absent puberty 66 30 Primary amenorrhea 68 31 Secondary amenorrhea 70 32 Hyperprolactinemia 72 33 Sexual dysfunction 74 34 Infertility 76 35 Multifetal pregnancy 78 36 Spontaneous pregnancy loss 80 37 Labor abnormalities 82 38 Pre-eclampsia 84 39 Benign and malignant diseases of the breast 86 40 Testicular tumors 88 41 Diseases of the prostate 90 42 Ovarian neoplasms 92 43 Endometrial cancer 94 44 Cervical cancer 96 45 Genetic imprinting and reproductive tract tumors 98 46 Sexually transmitted diseases of bacterial origin 100 47 Sexually transmitted diseases of viral origin 102 48 The special cases of syphilis and human immunodeficiency virus 104 Index 107

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Book SynopsisOur knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems.Table of ContentsList of Contributors xv 1 Anatomy of the Reproductive System 1Gheorghe M. Constantinescu 1.1 Male Genital Organs in Domestic Mammals 1 1.2 Female Genital Organs in Domestic Mammals 5 1.3 The Genital System in Domestic Mammals Species by Species 9 1.4 Genital Organs in Laboratory Mammals 35 References 56 2 Anatomy of Mammalian (Endocrine) Glands Controlling the Reproduction 59Gheorghe M. Constantinescu 2.1 The Hypothalamus Including the Hypophysis 59 2.2 The Cerebral Epiphysis 61 2.3 The Thyroid Gland 61 2.4 The Adrenal Glands 62 2.5 The Sexual Glands 63 2.6 The Liver 63 References 63 3 Models for Investigating Placental Biology 65Laramie Pence and Bhanu P. Telugu 3.1 Introduction 65 3.2 Classification of Placenta 66 3.3 Development of Human Placenta 69 3.4 Modeling Placental Development and Diseases of Placental Origin 73 3.5 Summary 82 References 82 4 Early Developmental Programming of the Ovarian Reserve, Ovarian Function, and Fertility 91Francesca Mossa, Siobhàn W. Walsh, Alex C.O. Evans, Fermin Jimenez-Krassel, and James J. Ireland 4.1 Introduction 91 4.2 Impact of Prenatal Environmental Challenges on Fetal Oogonia (Germ Cells) 92 4.3 Impact of Prenatal Environmental Challenges on Fetal Follicle/Oocyte Numbers (Healthy versus Atretic) and Oocyte Quality 94 4.4 Impact of Prenatal Environmental Challenges on the Ovarian Reserve (Total Number of Morphologically Healthy Follicles/Oocytes in Ovaries) in Offspring 95 4.5 Impact of Prenatal Environmental Challenges on Ovarian Function (e.g., Pituitary Gonadotropin Secretion, Ovarian Hormone/Growth Factor Production, Response to Gonadotropins, Follicle Development, Irregular Reproductive Cycles, and Ovulation Rate) in Offspring 98 4.6 Impact of Prenatal Environmental Challenges on Fertility (as Measured by Conception Rates, Fecundity, or Age at Puberty or Menopause) in Offspring 100 4.7 Summary and Conclusion 101 References 102 5 Small Non-Coding RNAS in Gametogenesis 109Lukasz Smorag and D. V. Krishna Pantakani 5.1 Small Non-Coding RNAs 109 5.2 Function of sncRNAs in Gametogenesis 109 Acknowledgment 119 References 119 6 The Ovarian Follicle of Cows as a Model for Human 127Marc-André Sirard 6.1 Introduction 127 6.2 A Similar Physiology of Folliculogenesis 128 6.3 Assisted Reproduction 131 6.4 Testing the Competence Hypothesis 136 6.5 Conclusion 136 References 136 7 Production of Energy and Determination of Competence: Past Knowledge, Present Research, and Future Opportunities in Oocyte and Embryo Metabolism 145Jason R. Herrick, Elena Silva, and Rebecca L. Krisher 7.1 Introduction 145 7.2 Measuring Metabolism 145 7.3 The Relationship Between Oocyte Metabolism and Quality 148 7.4 Embryo Metabolism 152 7.5 Metabolic Biomarkers 157 7.6 Toward Personalized Culture Media: Formulating Media for Specific Maternal Conditions 158 7.7 Summary 161 References 162 8 Signal Transduction Pathways in Oocyte Maturation 177François J. Richard, Nicolas Santiquet, Annick Bergeron, and Daulat Raheem Khan 8.1 Introduction 177 8.2 Phosphodiesterase 181 8.3 Gap Junction Communications 192 8.4 Metabolic Switch (AMPK) 193 8.5 Conclusion 198 References 198 9 Pig Models of Reproduction 213B.R. Mordhorst and R.S. Prather 9.1 Introduction 213 9.2 Early Embryonic Development 213 9.3 Oocyte Maturation 215 9.4 Fertilization 216 9.5 Tubouterine Contractility 216 9.6 Development to the Blastocyst Stage 216 9.7 Pregnancy and Developmental Programming 217 9.8 Puberty 222 9.9 Reproductive Disease 223 9.10 Summary 223 Acknowledgments 223 References 223 10 The Mare as an Animal Model for Reproductive Aging in the Woman 235Elaine M. Carnevale 10.1 Introduction 235 10.2 Ovarian Activity and Reproductive Cycles 236 10.3 The Follicle 238 10.4 Fertility 239 10.5 The Oocyte 240 10.6 Conclusions 242 References 242 11 Spotlight on Reproduction in Domestic Dogs as a Model for Human Reproduction 247Shirley J. Wright 11.1 Introduction 247 11.2 Dog Reproduction 255 11.3 Dog-Assisted Reproductive Technology 321 11.4 Dog Contraception 328 11.5 The Dog as a Model for Human Reproduction 328 11.6 Concluding Statements 332 Acknowledgments 333 References 333 12 Animal Models of Inflammation During Pregnancy 359Karen E. Racicot and Keith E. Latham 12.1 Introduction 359 12.2 Local Inflammation of the Pregnant Female Reproductive Tract 360 12.3 Systemic Inflammation During Pregnancy 361 12.4 Genetic Models and Cellular Manipulation to Study Inflammation During Pregnancy 365 12.5 Inflammation During Pregnancy and Offspring Disease 370 12.6 Perspectives and Conclusions 372 Acknowledgments 373 References 373 13 Practical Approaches, Achievements, and Perspectives in the Study on Signal Transduction in Oocyte Maturation and Fertilization: Focusing on the African Clawed Frog Xenopus laevisas an Animal Model 383Ken-ichi Sato 13.1 Introduction to Reproductive Biology of Frog Oocytes and Eggs 383 13.2 Practical Approaches 383 13.3 Achievements and Perspectives 395 Acknowledgments 396 Appendix 396 References 399 14 Prezygotic Chromosomal Examination of Mouse Spermatozoa 401Hiroyuki Watanabe and Hiroyuki Tateno 14.1 Introduction 401 14.2 Procedure of Sperm Chromosome Screening 402 14.3 Practical Use of SCS Before Fertilization 404 14.4 Conclusion 406 Acknowledgments 406 Addendum 406 References 406 15 Molecular and Cellular Aspects of Mammalian Sperm Acrosomal Exocytosis 409Florenza A. La Spina, Cintia Stival, Dario Krapf, and Mariano G. Buffone 15.1 Introduction 409 15.2 Structure of the Acrosome 409 15.3 Intermediate Stages of Exocytosis 412 15.4 Sperm Capacitation Prepare the Sperm to Undergo Acrosomal Exocytosis 412 15.5 Physiological Site for the Occurrence of Acrosomal Exocytosis 414 15.6 SNARES and Other Proteins from the Fusion Machinery 416 15.7 Hyperpolarization 417 15.8 Actin Cytoskeleton 417 15.9 Calcium 418 References 419 16 Sperm Chromatin Dynamics Associated with Male Fertility in Mammals 427Naseer A. Kutchy, Sule Dogan, Abdullah Kaya, Arlindo Moura, and Erdogan Memili 16.1 Introduction 427 16.2 Sperm Chromatin Structure Modulates Sperm Nuclear Shape and Function 429 16.3 The Bull Is a Suitable Model for the Study of Male Fertility in Humans 430 16.4 Conclusions and Prospects 430 Acknowledgments 431 References 431 17 Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development 435Jan Nevoral and Peter Sutovsky 17.1 Introduction 435 17.2 Milestones of Pronuclear Development 436 17.3 Nuclear Envelope, Nuclear Pore Complexes, and Nuclear Lamina Changes During Pronuclear Development 438 17.4 Molecular Mechanism of Paternal and Maternal Pronucleus Biogenesis 440 17.5 Role of UPS in Pronuclear Biogenesis 442 17.6 Posttranslational Modifications of Pronuclear Histones 443 17.7 Sirtuin Family Histone Deacetylases in Gametogenesis and Development 446 17.8 Clinical and Technological Considerations 447 17.9 Conclusions 450 Acknowledgments 450 References 450 18 Alterations of the Epigenome Induced by the Environment in Reproduction 467Zhao-Jia Ge, Shen Yin, and Heide Schatten 18.1 Introduction 467 18.2 Epigenetic Reprogramming 467 18.3 Environment and Epigenetic Alterations 470 18.4 Animal Models Used in Reproduction to Research Epigenetic Alterations Induced by the Environment 472 18.5 Effects of Environment on Epigenetic Modifications in Humans 475 18.6 Epigenetics and Assisted Reproductive Technology (ART) 475 18.7 Priorities for the Future 476 Acknowledgments 476 References 476 19 Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development 485Stoyan Petkov, Kristine Freude, Kaveh Mashayekhi, Poul Hyttel, and Vanessa Hall 19.1 Introduction 485 19.2 Current Status on the Pluripotent State in the Pig Embryo 489 19.3 Current Status of the Establishment of Porcine Embryonic Stem Cells (pESCs) 491 19.4 Current Status in Establishment of Porcine-Induced Pluripotent Stem Cells 494 19.5 Future Perspectives: Use of Global Profiling on Pluripotent Cells from Pig Embryo and Pluripotent Stem Cells 499 19.6 Discussion and Conclusions 501 Acknowledgments 502 References 502 20 Applications of Metabolomics in Reproductive Biology 509Ana Luiza Cazaux Velho, Rodrigo Oliveira, Thu Dinh, Arlindo Moura, Abdullah Kaya, and Erdogan Memili 20.1 Introduction 509 20.2 Metabolomics and Reproductive Biology 510 20.3 Metabolomics Studies in Large Animals as Models for Humans 513 20.4 Conclusions and Future Prospects 513 Acknowledgments 514 Conflict of Interest 514 References 514 21 Cryopreservation of Mammalian Oocytes 519Muhammad Anzar 21.1 Principles of Cryopreservation 519 21.2 Cryopreservation of Mammalian Oocytes 522 Acknowledgments 542 Abbreviations 543 References 543 Index 557

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Book SynopsisTable of ContentsContributors vii Preface viii How to use this book x Acknowledgements xi About the companion website xii Part 1: Introduction 1 1 What is reproduction? 3 2 The infrastructure of reproduction 13 Part 2: Making women and men 35 3 Sex 37 4 Sexual maturation 53 5 Gender 72 6 Sexual selection 88 Part 3: Preparing for pregnancy 107 7 Making sperm 109 8 Men 128 9 Making eggs 139 10 Women 158 Part 4: Making an embryo 181 11 Sperm and eggs 183 12 Fertilization 197 13 Initiating pregnancy 215 Part 5: Maintaining a pregnancy 237 14 Supporting the embryo and fetus 239 15 Growing the fetus 257 16 Fetal challenges 270 Part 6: A new individual 289 17 Preparing for birth 291 18 Giving birth 301 19 Lactation 318 20 Postnatal care 330 Part 7: Manipulating reproduction 345 21 Controlling fertility 347 22 Restoring fertility 363 23 Society and reproduction 383 Index 395

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Book SynopsisWith reproductive medical technologies becoming more accessible, assisted donor conception is raising new and important questions about family life. Using in-depth interviews the authors explore the lived reality of donor conception and offer insights into the complexities of these new family relationships.Trade Review"This book isn't a dry academic tome ... it is accessible and can be read by anyone with an interest in donor conception. I would strongly recommend it to parents of donor-conceived children to whom it could be enormously reassuring." - Sarah Norcross, BioNews "The insights gained in the in-depth interviews with members of lesbian and heterosexual couple families who have used donor conception are beyond anything I have ever come across before, and should be enormously helpful in re-assessing both the policy and practice of the range of support that needs to be in place at every stage of the donor conception family journey." - Olivia's View blog "The book is very interesting and a good illustration of some of some of the changes, dynamics and fluidities of family life." - Network: Magazine of the British Sociological Association "Intelligent and informed reflection on how the interviewees themselves have come to work on the relevant issues, how their own uses of metaphors relating to genes and the contribution of donor gametes have been shaped by their experiences, and how this work reflects on family life and kinship more widely." - Journal of Social Policy 'It is not often that an academic book can be described as truly delightful, but, in the case of Relative Strangers such a description is certainly appropriate.' Sociology of Health & IllnessTable of ContentsIntroduction 1. Proper Families? Cultural Expectations and Donor Conception 2. Uncharted Territories: Donor Conception in Personal Life 3. Ripples Through the Family 4. Keeping it Close: Sensitivities and Secrecy 5. Opening Up: Negotiating Disclosure 6. Donors: Strangers, Boundaries and Tantalising Knowledge 7. (Not) One of Us: Genes and Belonging in Family Life 8. Relative Strangers and the Paradoxes of Genetic Kinship

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Book SynopsisFetal development in the mouse is routinely and increasingly utilized for advancing translational research and medical innovation for human obstetrical care. This is the first and only manual to provide necessary content on how this should be handled for accurate and effective data collection. Detailed descriptions and examples demonstrate how researchers and clinicians can use murine fetal and obstetrical data to improve future human applications in diseases such as infertility, recurrent pregnancy loss, intrauterine fetal growth restriction, placental insufficiency, and intrauterine fetal demise, as well as organ-specific developmental disease.Table of ContentsAcknowledgements. Foreword by Carlos Simon and Cecilia Valdes. Preface. Implantation and Embryonic Imaging: Mouse until D4.5–9.5; Human 5–9 Weeks. Early Organogenesis and First Trimester: Mouse D10.5–12.5; Human 9–12 Weeks. Mid-Gestation and Second Trimester: Mouse D13.5–15.5; Human 13–27 Weeks. Central Nervous System and Facial Development: Mouse D13.5–15.5; Human 13–27 Weeks. Late-Gestation and Third Trimester: Mouse D16.5–18.5; Human 28–40 Weeks. Placenta Throughout Gestation. Index.

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Book SynopsisThis authoritative text for those training in Sexual Medicine now returns in a new edition that builds on what clinicians found most useful in the previous editions - physical and psychological background knowledge and all relevant treatments, combined with psychological therapies, principles, and case examples applied to common problems. Trade ReviewYou come away … with greater understanding of the pathophysiological underpinnings of illnesses and conditions, the psychosexual impact these can have …, and the ways in which psychosexual medicine can help.- BMJ Sexual & Reproductive Health Table of ContentsContributorsPART I: INTRODUCTION1. The Institute of Psychosexual Medicine Approach to Psychosexual Medicine as Practised by Health ProfessionalsMargaret Denman2. Identifying and Managing Problems in Different SettingsMargaret Denman3. When Bodies Speak: Psychosomatic Illness as Hidden CommunicationSandy Goldbeck-Wood4. Talking about SexCatherine HoodPART II: PHYSIOLOGY AND PSYCHOLOGY5. Physical Aspects of the Sex ResponseIan K. Walsh6. Psychological Background to Psychosexual MedicineCaroline Hunter7. Interaction of Mind and Body in Psychosexual MedicineCaroline Hunter8. Physical Treatments for Sexual ProblemsNicola Carter9. Sex and DisabilityNichola ChaterPART III: SKILLS10. Basic Communication Skills: The Here and Now/There and ThenGillian Vanhegan11. Defences in the Consultation: Developing Interpretative SkillsAndrew Stainer-Smith12. The Psychosexual Genital ExaminationJasmin Khan-SinghPART IV: APPLYING THE SKILLS TO THE PROBLEM13. Vaginismus and Non-ConsummationClaudine Domoney14. Female Sexual DesireAnnie Hawkins15. Erectile DysfunctionCatherine Coulson16. Ejaculation DisordersGareth Hughes17. Problems with Female OrgasmFiona Cowan18. Sexual Pain DisordersNikki M.W. Lee and Leila C.G. Frodsham19. TocophobiaLeila C.G. Frodsham20. Psychosexual Aspects of Sexual Preference and Gender Identity IssuesSusan V. Carr21. Internet Pornography: Addiction or Sexual Dysfunction?Catherine White22. Non-Consensual Sex and Psychosexual ProblemsSally Soodeen23. Vaginal DysmorphiaClare Gribbin24. Psychosexual Problems Approaching the End of LifeMarian DavisPART V: EFFECTIVENESS, SERVICES AND TRAINING25. Measuring Efficacy in Psychosexual MedicinePhilipa A. Brough26. ServicesPhilipa A. Brough27. Training in Psychosexual MedicineJasmin Khan-SinghIndex

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Book SynopsisThe most common abnormal growth of the female reproductive system, fibroids, are thought to affect the majority of women at some point during their reproductive years. This text from leading fibroid experts looks at the latest evidence on how the problem impinges on reproduction and the most up-to-date management and treatment options available to help patients with fibroids hoping to conceive.Print versions of this book also include access to the eBook version with links to procedural videos.Table of Contents1. Fibroids and Reproduction: A Bird’s-Eye View. 2. Fibroids and Assisted Reproduction Technology. 3. Fibroids and Endometrial Receptivity/Embryo Implantation. 4. Uterine Fibroids and Recurrent Pregnancy Loss. 5. Fibroids in Pregnancy. 6. Medical Options for Uterine Fibroids in the Context of Reproduction. 7. Fibroid Preoperative Imaging: Ultrasound. 8. Fibroid Preoperative Imaging: Magnetic Resonance Imaging. 9. Interventional Procedures. 10. Hysteroscopic Myomectomy. 11. Laparoscopic and Robotic-Assisted Myomectomy.

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Book SynopsisThis new edition of a groundbreaking book is now in two volumes, on ''Fundamentals, Symptoms, and Conditions on ''Reconstructive and Fertility Preserving Surgery and Procedures. From a distinguished editorial team and internationally recognized contributors the text educates surgeons on the techniques and procedures now needed in gynecology, with a special focus on reconstructive vaginal, hysteroscopic, laparoscopic, and laparotomic surgery, including that designed to preserve or enhance fertility. The reader can now more readily understand pathogenesis, appropriate investigation, and application of both surgical and nonsurgical strategies and techniques. The two volumes contain over 20 new chapters and in the integral ebook, over 140 instructional videos; each chapter has Key Points summarized.Table of ContentsEditors Contributors Introduction VOLUME 1: FUNDAMENTALS AND CONDITIONS1. Anatomy and surgical dissection of the female pelvis: For the gynecologic surgeonAndrew I. Brill, Robert M. Rogers, Jr., and Victor Gomel2. Reproductive physiology for the gynecological surgeonVictor Gomel, Malcolm G. Munro, and Peter F. McComb3. Energy-based surgical devicesAndrew I. Brill and Malcolm G. Munro4. Principles of laparoscopic surgerySukhbir S. Singh, Olga Bougie, and Malcolm G. Munro5. Principles of microprocessor-assisted laparoscopic ("robotic") surgeryErica Dun, Vadim Morozov, and Ceana Nezhat6. Principles of laparotomic and vaginal surgeryVictor Gomel and Malcolm G. Munro7. Principles of hysteroscopic surgeryBarry H. Sanders and Malcolm G. Munro8. Imaging for the gynecologic surgeonCaterina Exacoustos and Margit Dueholm9. Preservation of fertility in gynecologic surgery: Strategies and techniquesVictor Gomel, Mohamed A. Bedaiwy, and Recai Pabuççu10. Complications of surgery of the female reproductive tractNyia Noel, Christina Alicia Salazar, Keith Isaacson, and Malcolm G. Munro11. Congenital anomalies of the female reproductive tractJoseph S. Sanfilippo and Kathryn D. Peticca12. Ectopic pregnancyVictor Gomel and Malcolm G. Munro13. Endometrial polypsMarit Lieng and Jason A. Abbott14. Adenomyosis: Uterus-sparing treatmentGrigoris F. Grimbizis and Themistoklis Mikos15. Endometriosis: General principlesSukhbir S. Singh, Catherine Allaire, and David L. Olive16. Uterine leiomyomasLevent Mutlu, Kimberly W. Keefe, and Hugh S. Taylor17. Pathogenesis of pelvic floor disordersGeoffrey W. Cundiff18. Pelvic infections and their sequelaeJorma Paavonen19. Fallopian tube disordersVictor Gomel20. Postoperative adhesionsVictor Gomel and Philippe R. Koninckx21. Pathogenesis, pathology, and clinical significance of intrauterine adhesionsMiriam M.F. Hanstede, Mark Hans Emanuel, and Jason A. Abbott22. MalignancyDenis Querleu23. Chronic pelvic painFred M. Howard and Malcolm G. Munro24. Abnormal uterine bleedingMalcolm G. Munro25. The adnexal massDenis Querleu26. Diagnosis, investigation, and nonsurgical management of pelvic organ prolapse and urinary incontinenceYaël Levy-Zauberman and Hervé Fernandez27. Infertility: Mechanisms and investigationVictor Gomel28. Recurrent pregnancy loss: A new strategy for evaluation based on genetic testingWilliam H. Kutteh, Carolyn R. Jaslow, Paul R. Brezina, Raymond W. Ke, Amelia P. Bailey, and Mary D. StephensonVOLUME TWO: GYNECOLOGICAL SURGERY29. Surgery for congenital anomalies: Hysteroscopic, laparoscopic, laparotomic, and vaginalJoseph S. Sanfilippo, Kathryn D. Peticca, and Fabiola Balmir30. Surgery for vulvar disordersHoward T. Sharp31. Endometrial sampling and uterine curettageYaël Levy-Zauberman, Perrine Capmas, and Hervé Fernandez32. Management of endometrial polypsJason A. Abbott and Marit Lieng33. Endometrial ablationMalcolm G. Munro34. Surgery for intrauterine adhesionsMark Hans Emanuel and Miriam M.F. Hanstede35. Leiomyomas I: Hysteroscopic and other transvaginal approachesBarry H. Sanders and Malcolm G. Munro36. Leiomyomas II: Abdominal approachesWilliam H. Parker, Tommaso Falcone, and Malcolm G. Munro37. Leiomyomas III: Image-guided surgery and proceduresScott Chudnoff, Sukrant Mehta, and Eleanor Hawkins38. HysterectomyJon Ivar Einarsson and Mobolaji O. Ajao39. Reconstructive surgery of the fallopian tubeVictor Gomel40. Ectopic pregnancy: Surgical managementVictor Gomel41. Ovarian surgeryVictor Gomel and Mohamed A. Bedaiwy42. Endometriosis I: Surgery for endometriosis associated with painNicola Berlanda and Paolo P. Vercellini43. Endometriosis II: Surgical treatment of endometriosis associated with infertilityDavid L. Olive and Mauro Busaca44. Endometriosis III: Deep infiltrating endometriosisSukhbir S. Singh and Sugandha Agarwal45. Procedures specific for chronic pelvic painFred M. Howard46. Surgical treatment of urinary incontinenceYaël Levy-Zauberman, Xavier Deffieux, and Hervé Fernandez47. Management of pelvic organ prolapseGeoffrey W. Cundiff48. Surgery during intrauterine pregnancyMichel Canis, Nicolas Bourdel, Céline Houlle, Benoit Rabischong, Revaz Botchorishvili, and Jean L. Pouly49. Preservation of fertility in malignancyDenis Querleu, Sophie Deutsch-Bringer, and Alejandra Martínez50. Oocyte and embryo cryopreservation for fertility preservationAna Cobo and José RemohiIndex

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