Reproductive medicine Books

Book SynopsisUsing deconstruction, this book approaches contemporary problems raised by technologies of life and death from cloning to capital punishment; and thereby, provides new insights into current debates from a perspective outside of mainstream philosophy with its assumptions of individual and political sovereignty.Trade Review"In Technologies of Life and Death Kelly Oliver addresses some of the most intractable ethical issues of our day. The relevance of continental philosophy in general and of Derridean deconstruction in particular has rarely been demonstrated with such lucidity." -- -Robert Bernasconi Penn State University "In this creative, fascinating, witty, and remarkably fearless book, Oliver takes on the most important questions of human existence (including the meaning of birth and death and the limits of the human) and reframes them for us in thought-provoking ways." -- -Elissa Marder Emory University

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Book SynopsisCatherine Waldby trace how the history of the valuing of human oocytes—the reproductive cells specific to women—intersects with the biological and social life of women.Trade Review"What Waldby presents so compellingly is that there is an oocyte economy. Eggs have value and meaning, indeed they have different values and meanings in different contexts." -- Jane Maienschein * Journal of the History of Medicine and Allied Sciences *"Waldby has a long and impressive history of publications dealing with the social, political, ethical, and biomedical aspects of changing global markets for stem cells, umbilical cord blood, human eggs, fertilized blastocysts, embryos, and other (by-)products of artificially assisted reproduction." -- A. H. Koblitz * Choice *"The Oocyte Economy is not only a rigorous study but a riveting read." -- Claire Horn * Women's Review of Books *"This book offers a fascinating foray into the changing meaning of human oocytes for Western women and reproductive scientists. As such, it is a must-read for scholars of reproduction, and for related courses in anthropology, sociology, gender studies, and the history of science and medicine." -- Marcia C. Inhorn * Bulletin of the History of Medicine *"A thought-provoking and original examination of the emergence of an economy premised on deep cultural beliefs about the meaning of oocytes.… Likely to become required reading in medicine, gender, and in the interdisciplinary field of reproduction." -- Rosanna Hertz * Society *"The Oocyte Economy ultimately provides unparalleled insights into fertility practices to better conceptualize ethical arguments pertaining to assisted reproductive technologies. This book will appeal to social sciences and humanities scholars of medicine, especially those seeking refined theorizing on tissue donation made possible by the unique features of human eggs." -- Nathalie Egalite * International Journal of Feminist Approaches to Bioethics *"A fascinating account of the complex social meanings attached to egg cells and the possibilities and mysteries that technoscience is still unlocking about them. . . . The Oocyte Economy is replete with historical accounts and quotes from a range of different participants, making this book of particular interest to anybody interested in the expanding reproductive markets with a focus on tissue economies, IVF patients, and reproductive labor." -- Anna Molas * Medical Anthropology Quarterly *Table of ContentsAcknowledgments vii Introduction 1 1. Temporal Oocytes: Fertility and Deep Time 23 2. Twentieth-Century Oocytes: Experiment and Experience 41 3. Precious Oocytes: IVF and the Deficit Spiral 64 4. Global Oocytes: Medical Tourism and the Transaction of Fertility 88 5. Cold-Chain Oocytes: Vitrification and the Formation of Corporate Egg Banks 119 6. Private Oocytes: Personal Egg Banking and Generational Time 114 7. Innovation Oocytes: Therapeutic Cloning and Mitochondrial Donation 161 Conclusion 191 Appendix 199 Notes 205 References 211 Index 231

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Book SynopsisCatherine Waldby trace how the history of the valuing of human oocytes—the reproductive cells specific to women—intersects with the biological and social life of women.Trade Review"What Waldby presents so compellingly is that there is an oocyte economy. Eggs have value and meaning, indeed they have different values and meanings in different contexts." -- Jane Maienschein * Journal of the History of Medicine and Allied Sciences *"Waldby has a long and impressive history of publications dealing with the social, political, ethical, and biomedical aspects of changing global markets for stem cells, umbilical cord blood, human eggs, fertilized blastocysts, embryos, and other (by-)products of artificially assisted reproduction." -- A. H. Koblitz * Choice *"The Oocyte Economy is not only a rigorous study but a riveting read." -- Claire Horn * Women's Review of Books *"This book offers a fascinating foray into the changing meaning of human oocytes for Western women and reproductive scientists. As such, it is a must-read for scholars of reproduction, and for related courses in anthropology, sociology, gender studies, and the history of science and medicine." -- Marcia C. Inhorn * Bulletin of the History of Medicine *"A thought-provoking and original examination of the emergence of an economy premised on deep cultural beliefs about the meaning of oocytes.… Likely to become required reading in medicine, gender, and in the interdisciplinary field of reproduction." -- Rosanna Hertz * Society *"The Oocyte Economy ultimately provides unparalleled insights into fertility practices to better conceptualize ethical arguments pertaining to assisted reproductive technologies. This book will appeal to social sciences and humanities scholars of medicine, especially those seeking refined theorizing on tissue donation made possible by the unique features of human eggs." -- Nathalie Egalite * International Journal of Feminist Approaches to Bioethics *"A fascinating account of the complex social meanings attached to egg cells and the possibilities and mysteries that technoscience is still unlocking about them. . . . The Oocyte Economy is replete with historical accounts and quotes from a range of different participants, making this book of particular interest to anybody interested in the expanding reproductive markets with a focus on tissue economies, IVF patients, and reproductive labor." -- Anna Molas * Medical Anthropology Quarterly *Table of ContentsAcknowledgments vii Introduction 1 1. Temporal Oocytes: Fertility and Deep Time 23 2. Twentieth-Century Oocytes: Experiment and Experience 41 3. Precious Oocytes: IVF and the Deficit Spiral 64 4. Global Oocytes: Medical Tourism and the Transaction of Fertility 88 5. Cold-Chain Oocytes: Vitrification and the Formation of Corporate Egg Banks 119 6. Private Oocytes: Personal Egg Banking and Generational Time 114 7. Innovation Oocytes: Therapeutic Cloning and Mitochondrial Donation 161 Conclusion 191 Appendix 199 Notes 205 References 211 Index 231

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Book SynopsisFrançoise Vergès examines the scandal of white doctors forcefully terminating the pregnancies of thousands of poor women of color on the French island of Réunion during the 1960s, showing how they resulted from the legacies of the racialized violence of slavery and colonialism.Trade Review“In her wonderful book, Françoise Vergès creates a methodology for teasing out the various strands within which French Republican thought has sustained gender, class, and racial inequality. In doing so, she conceptualizes a new lexicon for postcolonial critique. From the scandal in Reunion to the forms of sovereignty that work within this logic, feminism needs to reconfigure itself if it is to be a force adequate to the future in the face of its previous ignorance. Vergès’s book takes us there.” -- Ranjana Khanna, author of * Algeria Cuts: Women and Representation, 1830 to the Present *"Verges' book… sets itself as an example of what kind of work is necessary to reveal the coloniality of power which persisted after the formal end of colonization. In other words, this book teaches us the kind of work needed to practice a decolonial feminism, a 'killjoy politics', a counterhegemonic strategy which appears fundamental to understand the genesis of femonationalism. There is a particularly valuable contribution made by the book which promises to become one of the most relevant new acquisitions in decolonial and feminist studies." -- Erika Bernacchi * Ethnic and Racial Studies *“It is precisely the stories that do not get told in the grand narrative of French republicanism—and, more pointedly, the why of their non-telling—that animates Françoise Vergès’s decolonial, antiracist feminist work, The Wombs of Women (seamlessly translated from the French by Kaiama Glover in supremely engrossing prose).” -- Chelsea Stieber * Public Books *"Vergès's ability to make us focus specifically on colonial and post-colonial France is a feat worthy unto itself and makes this an important contribution to French feminist theory and post-colonial historiography.… An important book for any nation unpacking the not quite extinguished remnants of colonial paternalism.… It should be read alongside more so-called traditional histories of France, to act as a corrective to ongoing narratives of French self-identity." -- Robin Mitchell * H-France *"One of the ambitious aims of this book is to spark the development of a decolonial feminism which Vergès asserts requires delving into the past and rescuing ‘entire periods of history’ (p 115) from oblivion. This book achieves this so well, depicting the urgent need to rethink feminism through a decolonial lens and offers a significant contribution to postcolonial studies." -- Natasha Lila Rooney * Postcolonial Studies *"Vergès makes a powerful case for the geography closest in—here, the womb and its capacity for reproductive futures—as the grounds of any decolonial feminist history worthy of the name." -- Antoinette Burton * French Politics, Culture & Society *Table of ContentsPreface ix Translator's Introduction xiii Introduction 1 1. The Island of Doctor Moreau 1 2. The Rhetoric of "Impossible Development": Dependency, Repression, and Anticolonial Struggle 29 3. The Wombs of Black Women, Capitalism, and the International Division of Labor 49 4. "The Future Is Elsewhere" 63 5. French Feminist Blindness: Race, Coloniality, Capitalism 89 Conclusion: Repoliticizing Feminism 115 Notes 125 Index 157

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Book SynopsisIn the 1960s thousands of poor women of color on the (post)colonial French island of Reunion had their pregnancies forcefully terminated by white doctors; the doctors operated under the pretext of performing benign surgeries, for which they sought government compensation. When the scandal broke in 1970, the doctors claimed to have been encouraged to perform these abortions by French politicians who sought to curtail reproduction on the island, even though abortion was illegal in France. In The Wombs of Women—first published in French and appearing here in English for the first time—Françoise Vergès traces the long history of colonial state intervention in black women’s wombs during the slave trade and postslavery imperialism as well as in current birth control politics. She examines the women’s liberation movement in France in the 1960s and 1970s, showing that by choosing to ignore the history of the racialization of women’s wombs, FreTrade Review“In her wonderful book, Françoise Vergès creates a methodology for teasing out the various strands within which French Republican thought has sustained gender, class, and racial inequality. In doing so, she conceptualizes a new lexicon for postcolonial critique. From the scandal in Reunion to the forms of sovereignty that work within this logic, feminism needs to reconfigure itself if it is to be a force adequate to the future in the face of its previous ignorance. Vergès’s book takes us there.” -- Ranjana Khanna, author of * Algeria Cuts: Women and Representation, 1830 to the Present *"Verges' book… sets itself as an example of what kind of work is necessary to reveal the coloniality of power which persisted after the formal end of colonization. In other words, this book teaches us the kind of work needed to practice a decolonial feminism, a 'killjoy politics', a counterhegemonic strategy which appears fundamental to understand the genesis of femonationalism. There is a particularly valuable contribution made by the book which promises to become one of the most relevant new acquisitions in decolonial and feminist studies." -- Erika Bernacchi * Ethnic and Racial Studies *“It is precisely the stories that do not get told in the grand narrative of French republicanism—and, more pointedly, the why of their non-telling—that animates Françoise Vergès’s decolonial, antiracist feminist work, The Wombs of Women (seamlessly translated from the French by Kaiama Glover in supremely engrossing prose).” -- Chelsea Stieber * Public Books *"Vergès's ability to make us focus specifically on colonial and post-colonial France is a feat worthy unto itself and makes this an important contribution to French feminist theory and post-colonial historiography.… An important book for any nation unpacking the not quite extinguished remnants of colonial paternalism.… It should be read alongside more so-called traditional histories of France, to act as a corrective to ongoing narratives of French self-identity." -- Robin Mitchell * H-France *"One of the ambitious aims of this book is to spark the development of a decolonial feminism which Vergès asserts requires delving into the past and rescuing ‘entire periods of history’ (p 115) from oblivion. This book achieves this so well, depicting the urgent need to rethink feminism through a decolonial lens and offers a significant contribution to postcolonial studies." -- Natasha Lila Rooney * Postcolonial Studies *"Vergès makes a powerful case for the geography closest in—here, the womb and its capacity for reproductive futures—as the grounds of any decolonial feminist history worthy of the name." -- Antoinette Burton * French Politics, Culture & Society *Table of ContentsPreface ix Translator's Introduction xiii Introduction 1 1. The Island of Doctor Moreau 1 2. The Rhetoric of "Impossible Development": Dependency, Repression, and Anticolonial Struggle 29 3. The Wombs of Black Women, Capitalism, and the International Division of Labor 49 4. "The Future Is Elsewhere" 63 5. French Feminist Blindness: Race, Coloniality, Capitalism 89 Conclusion: Repoliticizing Feminism 115 Notes 125 Index 157

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Book SynopsisBrown Bodies, White Babies focuses on the practice of cross-racial gestational surrogacy, in which a woman - through in-vitro fertilization using the sperm and egg of intended parents or donors - carries a pregnancy for intended parents of a different race. Focusing on the racial differences between parents and surrogates, this book is interested in how reproductive technologies intersect with race, particularly when brown bodies produce white babies. While the potential of reproductive technologies is far from pre-determined, the ways in which these technologies are currently deployed often serve the interests of dominant groups, through the creation of white, middle-class, heteronormative families. Laura Harrison, providing an important understanding of the work of women of color as surrogates, connects this labor to the history of racialized reproduction in the United States. Cross-racial surrogacy is one end of a continuum in which dominant groups rely on the reproductive potentialTrade Review[A] refreshingly new take...add[ing] complexity to the well-trod feminist discussion... * Signs *Brown Bodies, White Babies reveals fresh insights on the politics of reproduction in the United States and globally by investigating the racialized and gendered meanings of kinship in the context of cross-racial gestational surrogacy when a surrogate is not the same race as the intended parents. Despite surrogacys seemingly radical potential, Harrison brilliantly shows how these arrangements reinforce genetic determinism, white privilege, and the biological concept of race. An important and provocative contribution to critical analyses of assisted reproduction. -- Dorothy Roberts,author of Killing the Black Body: Race, Reproduction, and The Meaning of LibertyAn indispensable contribution, this book historicizes the ideologies of race and racial transmission that cut through the heart of reproductive labor right from wet nursing in the emergent American colonies to present-day cross-racial surrogacy. A must-read for any student of reproductive justice. -- Sharmila Rudrappa,author of Discounted Life: The Price of Global Surrogacy in IndiaIn a refreshingly clear, engaging, jargon-free voice, Harrison introduces readers to the role of race in the discourse surrounding surrogacy in the United States. Her interdisciplinary, qualitative analysis of cross-racial surrogacy in popular media, legal cases and on websites provides an important addition to the sociology and anthropology of reproduction. -- Elly Teman,author of Birthing a Mother: The Surrogate Body and the Pregnant SelfLaura Harrisons bookBrown Bodies, White Babies: The Politics of Cross-Racial Surrogacyprovides readers with a comprehensive and insightful analysis of surrogacy using both intersectional theory and discourse analysis, before concluding with a call for activism and engagement. * Hypatia Reviews *

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Book SynopsisWelcomed as liberation and dismissed as exploitation, egg freezing (oocyte cryopreservation) has rapidly become one of the most widely-discussed and influential new reproductive technologies of this century. In Freezing Fertility, Lucy van de Wiel takes us inside the world of fertility preservationwith its egg freezing parties, contested age limits, proactive anticipations and equity investmentsand shows how the popularization of egg freezing has profound consequences for the way in which female fertility and reproductive aging are understood, commercialized and politicized.Beyond an individual reproductive choice for people who may want to have children later in life, Freezing Fertility explores how the rise of egg freezing also reveals broader cultural, political and economic negotiations about reproductive politics, gender inequities, age normativities and the financialization of healthcare. Van de Wiel investigates these issues by analyzing a wide range of sourcesvaTrade ReviewA timely and powerful book … a jam-packed guide to the politics of reproductive ageing in a world of rapid social and technological change … will be of interest to a wide audience, from general readership to students, policymakers and social scientists working on reproduction and family politics. * BioNews *Lucy van de Wiel’s Freezing Fertility brilliantly investigates fertile embodiment through a transnational exploration of human fertility preservation practices. Egg freezing, a recent biotechnological innovation, enhances corporeal capacities and transforms the temporality of everyday life. Her germinal analysis offers powerful interpretations of emerging cultural anxieties when we interrupt the imperative of ‘a biological clock’. -- Lisa Jean Moore, author of Catch and Release: The Enduring Yet Vulnerable Horseshoe CrabIn this beautifully-written and thought-provoking book, Lucy van de Wiel follows the egg from ovary to freezer and beyond. Grappling with the social, ethical, and economic complexities of egg freezing, she offers a vital contribution to debates about gender, reproduction, and aging. -- Rene Almeling, author of Sex Cells: The Medical Market for Eggs and SpermThis volume is a brilliant foray into the contested world of egg freezing, taking readers on a journey with the human egg from its in vivo existence in ovaries and wombs to ex vivo sites of cryostorage, finance, and experimentation. Offering the single best analysis of the precarious relationship between fertility, reproductive technology, and women’s aging, Freezing Fertility is a must-read for gender, STS, and cultural studies scholars, as well as anyone interested in the future of assisted reproduction. -- Marcia C. Inhorn, author of Cosmopolitan Conceptions: IVF Sojourns in Global Dubaian important contribution to medical anthropology and feminist technoscience and will be an excellent addition to the academic literature on this recently expanding practice, allowing us to prepare for what might come. The book is beautifully written, the main arguments are carefully elaborated and thought-provoking, and the key message is unsettling. * Medical Anthropology Quarterly *Lucy van de Wiel’s Freezing Fertility is a beautifully written exploration of the cultural discourse of frozen eggs and their related technologies. -- Lauren Jade Martin of Penn State University, Berks * American Journal of Sociology *

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Book SynopsisBrown Bodies, White Babies focuses on the practice of cross-racial gestational surrogacy, in which a woman - through in-vitro fertilization using the sperm and egg of intended parents or donors - carries a pregnancy for intended parents of a different race. Focusing on the racial differences between parents and surrogates, this book is interested in how reproductive technologies intersect with race, particularly when brown bodies produce white babies. While the potential of reproductive technologies is far from pre-determined, the ways in which these technologies are currently deployed often serve the interests of dominant groups, through the creation of white, middle-class, heteronormative families. Laura Harrison, providing an important understanding of the work of women of color as surrogates, connects this labor to the history of racialized reproduction in the United States. Cross-racial surrogacy is one end of a continuum in which dominant groups rely on the reproductive potentialTrade Review[A] refreshingly new take...add[ing] complexity to the well-trod feminist discussion... * Signs *Brown Bodies, White Babies reveals fresh insights on the politics of reproduction in the United States and globally by investigating the racialized and gendered meanings of kinship in the context of cross-racial gestational surrogacy when a surrogate is not the same race as the intended parents. Despite surrogacys seemingly radical potential, Harrison brilliantly shows how these arrangements reinforce genetic determinism, white privilege, and the biological concept of race. An important and provocative contribution to critical analyses of assisted reproduction. -- Dorothy Roberts,author of Killing the Black Body: Race, Reproduction, and The Meaning of LibertyAn indispensable contribution, this book historicizes the ideologies of race and racial transmission that cut through the heart of reproductive labor right from wet nursing in the emergent American colonies to present-day cross-racial surrogacy. A must-read for any student of reproductive justice. -- Sharmila Rudrappa,author of Discounted Life: The Price of Global Surrogacy in IndiaIn a refreshingly clear, engaging, jargon-free voice, Harrison introduces readers to the role of race in the discourse surrounding surrogacy in the United States. Her interdisciplinary, qualitative analysis of cross-racial surrogacy in popular media, legal cases and on websites provides an important addition to the sociology and anthropology of reproduction. -- Elly Teman,author of Birthing a Mother: The Surrogate Body and the Pregnant SelfLaura Harrisons bookBrown Bodies, White Babies: The Politics of Cross-Racial Surrogacyprovides readers with a comprehensive and insightful analysis of surrogacy using both intersectional theory and discourse analysis, before concluding with a call for activism and engagement. * Hypatia Reviews *

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Book SynopsisSubstantial Relations examines global reproductive medicine in India, focusing on in vitro fertilization. Since the 1970s, India has played a central but shifting role in shaping global reproductive medicinefrom a provider of raw material, to a producer of knowledge and technology, to a creator of a thriving medical market that attracts patients from all over the world. Relying on archival material and oral history, Substantial Relations traces the path of this transnational historical trajectory. This book also examines the contemporary making of IVF in Delhi. Drawing on ethnographic research in homes, hospitals, and laboratories, Sandra Bärnreuther provides deep insights into the intricacies of clinical life and everyday experience by depicting IVF users'' quest for offspring and their fears of establishing unwanted ties, as well as the minute engagements of clinicians and laboratory staff with reproductive substances.Thinking through substancesmTrade ReviewBärnreuther (Univ. of Lucerne, Switzerland) skillfully uses anthropological fieldwork (conducted from 2010 to 2017) and archival research to describe and analyze this growing IVF medical system. * Choice *The book is a recommended read for all scholars working in the area of infertility/fertility and kinship studies. * Medical Anthropology Quarterly *Table of ContentsIntroduction 1. From Urine to Ampoule: The Commodity Chain of a Hormone 2. From Dismissal to Recognition: A Contested Claim 3. From Hobby to Industry: How IVF Diversified 4. The Clinic and Beyond: Reproductive Temporalities 5. When Cells Circulate: Unwanted Ties 6. Inside the Laboratory: Embryo Ethics Epilogue

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Book SynopsisPediatric Collections offers what you need to know - original, focused research in a snapshot approach. The teen pregnancy and birth rates have decreased in the US in the past 30 years due to factors such as the availability of more hormonal contraceptive options and delayed initiation of sexual intercourse. However, the US still has one of the highest teen pregnancy rates of industrialized countries. Moreover, disparities in teen pregnancy and birthrates still exist due mostly to social determinants of health. This all points to the increased need of pediatric providers to provide comprehensive reproductive health to all adolescents they care for. Now, more than ever, pediatric providers are counted on to provide evidence-based, comprehensive reproductive and sexual healthcare to the adolescents and young adults they care for. A pediatrician’s goal is to ensure all children grow to be the healthy, successful, and productive adults they were meant to be. Guiding them through the challenge of adolescence and providing comprehensive reproductive health care can help make that goal a reality.Table of ContentsIntroduction by Elizabeth Alderman, MD, FAAP 1 After “The Talk”: Adolescents’ Perspectives Reveal Need for Improvement in Hospital Sexual Health Care Delivery Original Article Original Publication February 1, 20232 Adolescent and Young Adult Menstrual Poverty: A Barrier to Contraceptive Choice Equity, Diversity, Inclusion, and Justice Original Publication January 1, 20233 Geographic Distribution of Clinical Care for Transgender and Gender-Diverse Youth Original Article Original Publication December 1, 20224 Improving HPV Vaccination Rates in a Racially and Ethnically Diverse Pediatric Population Quality Report Original Publication October 1, 20225 Dobbs v. Jackson Decision: It’s Time to Get Uncomfortable Perspectives Original Publication October 1, 20226 Options Counseling for the Pregnant Adolescent Patient Policy Statement Original Publication September 1, 20227 The Adolescent’s Right to Confidential Care When Considering Abortion Policy Statement Original Publication September 1, 20228 Human Papillomavirus Vaccination Trends Among Adolescents: 2015 to 2020 Original Article Original Publication July 1, 20229 Long-Acting Reversible Contraception: Specific Issues for Adolescents Clinical Report Original Publication August 1, 202010 Barrier Protection Use by Adolescents During Sexual Activity Technical Report Original Publication August 1, 202011 Emerging Issues in Male Adolescent Sexual and Reproductive Health Care Clinical Report Original Publication May 1, 202012 Emergency Contraception Policy Statement Original Publication December 1, 2019

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Book SynopsisThis book describes the principles and skills of counselling. It provides practical guidelines which show, by example how to communicate effectively, how to offer counselling and support, and how to face and deal with difficult situations. Detailed attention is given to issues such as preparing women for surgery, breaking bad news, and providing information and support before, during and after childbirth.Table of Contents1. Theories and Practices. 2. Experiences of reproductive problems. 3. Counselling. 4. Initial contact. 5. Providing information and support. 6. New perspectives and problem solving. 7. Conclusions.

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Book SynopsisWith contributions from: Eric Blyth, Ken Daniels, Julia Feast, Robert Lee, Nina Martin, Alexina McWhinnie, Derek Morgan, Clare Murray, Sharon Pettle, Claire Potter, Jim Richards and Francoise Shenfield The separation of procreation from conception has broadened notions of parenthood and created novel dilemmas. A woman may carry a foetus derived from gametes neither or only one of which came from her or her partner; or she may carry a foetus created using in vitro fertilisation (IVF) with the purpose of handing it to two other parents one, neither or both of whom may be genetically related to the prospective child. Parents may consist of single-sex couples, only one of them genetically related to the child; the prospective mother may be past her menopause; and genetic parenthood after death is now achievable. In a world increasingly reliant on medical science, how can the argument that equates traditional with natural and novel with unnatural/unethical be justified? Should there be legislation, which is notoriously slow to change, in a field driven by dazzling new possibilities at ever faster rate; particularly when restrictions differ from country to country, so that those who can afford it travel elsewhere for their treatment of choice? Whose rights are paramount - the adults hoping to build a family or the prospective child(ren)s future well being? On what basis can apparently competing rights be regulated or adjudicated and how and to what extent can these be enforced in practice?Table of ContentsContributors. Foreword (Professor Susan Golombok). Introduction. Chapter 1: Assisted human reproduction: contemporary policy and practice in the UK (Eric Blyth, Nina Martin and Claire Potter). Chapter 2: Issues of gamete donation and sex selection: a clinician's view (Francoise Shenfield). Chapter 3: Ethical issues - the major faiths: a personal view (Jim Richards). Chapter 4: Human reproduction and human rights (Derek Morgan and Robert G. Lee). Chapter 5: Donor-assisted conception: what can we learn from adoption? (Julia Feast). Chapter 6: Children raised in assisted human reproduction families: the evidence (Clare Murray). Chapter 7: Disclosure and development: 'taking the bady home was just the beginning' (Alexina M. McWhinnie). Chapter 8: Psychological therapy and counselling with individuals and families afrter donor conception (Sharon A. Pettle). Chapter 9: Policy development in third party reproduction: an international perspective (Ken Daniels). Appendix: Resources. Index.

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Book SynopsisOne out of every six patients in the United States is treated in a Catholic hospital that follows the policies of the U.S. Conference of Catholic Bishops. These policies prohibit abortion, sterilization, contraception, some treatments for miscarriage and gender confirmation, and other reproductive care, undermining hard-won patients’ rights to bodily autonomy and informed decision-making. Drawing on rich interviews with patients and providers, this book reveals both how the bishops’ directives operate and how people inside Catholic hospitals navigate the resulting restrictions on medical practice. In doing so, Bishops and Bodies fleshes out a vivid picture of how The Church’s stance on sex, reproduction, and “life” itself manifests in institutions that affect us all.Trade Review"Shortly after the Supreme Court issued its opinion in Dobbs v. Jackson Women’s Health Organization, horrific stories began to emerge from hospitals across the country. To many, these denials of emergency medical care seemed to be an alarming new consequence of the Supreme Court’s decision. Lori Freedman, however, has documented such stories for well over a decade. We would do well to study her work carefully — including her book Bishops and Bodies: Reproductive Care in American Catholic Hospitals — in this critical moment. * Catholics for Choice *“It’s a recipe for disaster—the Catholic Church wants the most births possible, and most American women want to limit their childbearing and protect their health with modern advances in contraception and abortion. Yet in the name of corporate conscience, our anachronistic laws allow Catholic healthcare to require physicians of all faiths to do things that violate medical ethics and often constitute malpractice. Freedman’s compelling research, rich storytelling, and incisive analysis reveal how outrageous Bishop-knows-best medicine really is.” -- Katie Watson * author of Scarlet A: The Ethics, Law and Politics of Ordinary Abortion *"Bishops and Bodies is poised to make a significant impact not just in social science and medical humanities circles, but in broader public conversations about health care, reproductive rights, and the place of religion in society." -- Jessica Martucci * author of Back to the Breast: Natural Motherhood and Breastfeeding in America *Table of ContentsForeword by Debra Stulberg Prologue: Unsafe and Unequal Introduction: Doctrinal Iatrogenesis 1 Growth: How Catholic Health Care Expanded 2 Inferior: How Catholic Directives Contradict Medical Standards 3 Consumer Medicine? Patients and the Illusion of Choice 4 Emergencies: Patient Loss and Suffering 5 Mostly Above-Board Workarounds 6 Under the Radar Workarounds 7 Separation of Church and Hospital 8 Conclusion Acknowledgements Appendix Notes Index

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Book SynopsisThis book presents the latest insights into all the critical aspects of Klinefelter’s Syndrome, in order to promote a more homogeneous a medical approach to this condition, leading to better and more “evidence-based” support, and improving patient satisfaction.It offers physicians and all health professionals involved in treating these patients (andrologists, pediatricians, endocrinologists, psychologists) a comprehensive overview and a useful tool for their daily clinical practice.Table of ContentsPoetry Preface 1. Introduction - From a disabling condition to a variant of normalcy 2. Epidemiology of an underdiagnosed syndrome 3. Causes of the extra chromosome/s 4. Different karyotypes, same disease? 5. Genetic and epigenetic aspects of the supernumerary X chromosome 6. Prenatal Counselling and management in the early neonatal period 7. EARLY DEVELOPMENTAL PATHWAYS AND COMMUNICATION GOOD PRACTICES 8. THE DIAGNOSIS AT PREPUBERTAL AGE 9. WHAT TO DO AND WHEN FROM INFANCY TO PUBERTY 10. Neuropsychiatric aspects 11. Testicular development 12. THE KLINEFELTER PUBERTY 13. GENETIC OF GAMETES 14. Phenotype of the adulthood 15. Hypothalamic-Pituitary Axis Function 16. the altered bone 17. Obesity, the rule or not 18. Lipids and glucose metabolism 19. Cardiovascular characteristics 20. The Thyroid Function 21. ONCOLOGICAL PROBLEMS 22. FERTILITY PRESERVATION 23. Fertility vs Infertility 24. Psychological features 25. Sexual function 26. Testosterone treatment in male patients with Klinefelter’s syndrome

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Book SynopsisThis book aims to address a number of controversies concerning the use of testosterone treatment. It explains topics that clinicians regularly encounter such as whether to use free or total testosterone in the evaluation of the patient with testosterone deficiency; what factors actually impact testosterone levels, polycythemia, gynecomastia, bone density, and hyperprolactinemia in the testosterone deficient patient; critical analysis of the numerous questionnaires that are available to clinicians; and the impact of testosterone therapy on male fertility, cardiovascular disease, and prostate events including prostate cancer. Guiding the reader in both evaluation and management, the book also illuminates novel concepts in the T space such as testosterone use in the transgender population, T therapy as an endothelial modulator, bipolar testosterone therapy in the patient with advanced prostate cancer, and testosterone therapy as a performance enhancer.Controversies in Testosterone Deficiency is intended for any clinician involved in the care of patients with testosterone deficiency, exploring hot topics and correcting existent misinformation in the routine care of patients.Table of ContentsWhat to Measure: Testosterone or Free Testosterone?.- Erythrocytosis in Patients on Testosterone Therapy.- Role of Gonadotropins in Adult-Onset Functional Hypogonadism.- Hyperprolactinemia in the Man with Testosterone Deficiency.- Testosterone and Disordered Sleep.- Testosterone Therapy and Male Fertility.- Testosterone and Prostate Effects.- Testosterone in Females.- Testosterone in Transgender Population.- Testosterone as a Performance Enhancer.

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Book SynopsisNow in a completely newly revised and expanded second edition, this comprehensive text presents the current state of the art in our understanding and management of polycystic ovary syndrome (PCOS), the most common hormonal disorder of reproductive aged women. The numerous bothersome symptoms of PCOS include menstrual irregularities, hirsutism, acne, scalp hair thinning, weigh excess and infertility; additionally, as they age, women with PCOS are at a higher risk for metabolic abnormalities such as diabetes and dyslipidemias, as well as for cardiovascular disease and even certain cancers. Despite improvements in our understanding of this condition, the exact cause/s of PCOS remain elusive; genetic, hormonal, metabolic and environmental underpinnings are all suggested as relevant. All chapters have been updated, with eight new chapters added across seven thematic sections. Part one discusses the epidemiology of PCOS in both adults and adolescents. Part two covers the pathophysiology of PCOS, including genetics, the hypothalamo-pituitary-ovarian and the hypothalamo-pituitary-adrenal axes, insulin resistance, inflammation, and obesity. The next three sections present the various management strategies, medical and surgical, for harnessing the symptomatology, including PCOS-related infertility; these chapters include added case material to provide real-world examples of the treatments in action and their efficacy. Part six covers the comorbidities that women with PCOS commonly encounter, such as issues of mental health, sleep disturbances, endometrial hyperplasia, and cancer, as well as examines the economic burden of PCOS. The final section discusses emerging concepts surrounding possible mechanisms and potential therapeutic approaches to PCOS, including angiogenic dysfunction, the role of vitamin D, future potential therapies to targeted AMH signaling. The closing chapter, by familiarizing the readers with the intergenerational implications of PCOS and by raising awareness of potential “ripple effects”, aims at alerting the community on a need for vigilance as regards the health of PCOS progeny. With contributions from leaders in the field, Polycystic Ovary Syndrome, Second Edition remains the gold-standard text on this common medical condition and a valuable resource for the wide range of healthcare professionals engaged in caring for the women with PCOS (including but not limited to reproductive endocrinologists, gynecologists, family physicians, dermatologists, mental health professionals), for the aspiring women's health providers of tomorrow, and for the researchers who are striving to unravel the mysteries of the complex entity that PCOS is.Table of Contents

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Book SynopsisThis book is a point-of-care resource for effective sexual and reproductive healthcare for patients of all ages, sexual orientations, gender identities and medical backgrounds in the primary care setting. This useful guide is divided into three parts, and other than part three, which deals exclusively with transgender and gender diverse patients, all content will relate to patients of all gender identities. Part one presents sexual and reproductive health (SRH) using a lifespan approach, including chapters on pediatrics, adolescents and young adults, adults, and older adult patients. Part two presents an approach to common SRH issues that span multiple age groups, including contraception and family planning, sexually transmitted infections and cancer screenings as well as sexual and reproductive health in the setting of common medical conditions. Part three is dedicated to sexual and reproductive health for transgender and gender non-binary patients, including psychosocial, medical, surgical and legal aspects of health. This book provides primary care clinicians with a framework for providing effective sexual and reproductive healthcare to patients of all ages, sexual orientations and gender identities in a way that is inclusive, focuses on health, and addresses the needs unique to specific populations.Trade Review Table of Contents

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Book SynopsisNow in a completely revised and expanded fourth edition, including two new chapters, this user-friendly textbook offers a succinct overview of both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities. Included here are updated chapters on major reproductive endocrinology and infertility issues, such as polycystic ovary syndrome (PCOS), pubertal disorders, amenorrhea, menopause, management of endometriosis and fibroids (including interventional radiology), laboratory and clinical aspects of assisted reproductive technologies (ART), imaging modalities such as ultrasonography and sonohysterography, hysteroscopic and laparoscopic techniques, an expansion of female infertility and fertility, preimplantation diagnosis and screening, osteoporosis, and contraception and sterilization. Chapters new to this edition discuss third-party reproduction and uterine transplantation. In addition, chapters opens with a list of bulleted key points and end with multiple choice review questions, and most include vibrant clinical case material to illustrate important concepts. Residents, fellows, and new clinicians in obstetrics and gynecology interested in reproductive endocrinology and infertility will find this fourth edition of Clinical Reproductive Medicine and Surgery: A Practical Guide a valuable and focused reference.Table of ContentsHypothalamic-Pituitary-Ovarian Axis and Control of the Menstrual Cycle.- Female and Male Gametogenesis.- Normal Puberty and Pubertal Disorders.- Fertilization and Implantation.- Reproductive Imaging.- Amenorrhea.- Polycystic Ovary Syndrome.- Abnormal Uterine Bleeding.- Menopause.- Osteoporosis for the Female Patient.- Male Infertility.- Female Infertility.- Fertility Preservation.- Ovarian Reserve Testing.- Recurrent Early Pregnancy Loss.- Induction of Ovulation.- Assisted Reproductive Technology: Clinical Aspects.- Assisted Reproductive Technology: Laboratory Aspects.- Preimplantation Genetic Diagnosis and Genetic Screening.- Hysteroscopic Management of Intrauterine Disorders.- Gynecologic Laparoscopy.- Uterine Leiomyomas.- Tubal Disease and Ectopic Pregnancy.- Endometriosis.- Contraception and Sterilization.- Surgical Techniques for Management of Anomalies of the Mullerian Ducts.- Third-party Reproduction.- Uterine Transplantation.

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Book SynopsisThis open access book focuses on of the impact of endocrine disrupting chemicals (EDCs) on human reproduction. It comprehensively discusses the three most important topics in the field: the basic biology of EDCs; the effects of EDCs on human reproduction and human reproductive systems; and potential interventions and practical advice for dealing with the problems caused by EDCs.Presenting a translational approach to endocrine disrupting chemicals research, spanning both basic biology and clinical applications, the book provides a critical link between laboratory investigations and clinical practice. Written by international experts in the field, it is a valuable reference resource for gynaecologists, obstetricians, endocrinologists and experts in reproductive medicine, and a useful tool for anyone interested in the impact of the environment on human reproduction.Table of Contents​Introduction to Environmental Pollutants and Human Exposure.- Cellular Mechanisms of Endocrine Disruption.- Endocrine Disruptors, Epigenetic changes and Transgenerational Transmission.- Introduction to Environmental Pollutants and Human Reproduction.- Endocrine Disruption in the Female (PCOS, Early puberty, Endometriosis).- Endocrine Disrupting Chemicals and Female Cancer.- Endocrine Disruption in the Male.- Endocrine Disrupting Chemicals and Reproductive Outcome.- Endocrine Disrupting Chemicals and the Offspring (Prenatal exposure).- Policy Implication and Community Interventions to reduce EDCs Exposure.- Talking with patients and the public about EDCs (+ Video).

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Book SynopsisIntroduction.- The Disparities in ART (DART) hypothesis of racial and ethnic disparities in access and outcomes of IVF treatment in the US.- Racial and Ethnic Groups in Fertility Research.- Fertility Differences Among Racial/Ethnic groups.- Socioeconomic and Economic Factors in Seeking Fertility Services.- PCOS among Racial and Ethnic Groups.- Racial diversity and uterine Fibroids.- Racial/ethnic disparities in stress as it impacts reproductive outcomes.- Racial Disparities between Black and white access and outcomes to infertility treatment and ART in the US.- Fertility and ART outcome in Hispanic Women.- Reproductive and ART outcome in East Asian Women.- Infertility and ART outcomes in South Asian Couples.- PGT-A Outcomes Across Racial and Ethnic groups.- Racial/Ethnic Disparities in Oocyte Donation (both fresh and frozen).- FET Outcomes Across Racial/Ethnic Groups.- Recurrent Pregnancy Loss across Different Ethnicities.- Racial/Ethnic Disparities in Egg Freezing.- Impact of Insurance on Racial Disparities in ART.- Obesity and Its Impact on Racial/Ethnic Differences in Fertility and ART.- Understanding Racial Disparity in Adverse Pregnancy Outcome.- Artificial Intelligence (AI) and Health Equity.- The Potential Impact of the Dobbs Decision Upon Health Equity in Access and ART Treatment Outcomes in the US.

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Book SynopsisIntroduction to NOA.- Endocrine aberrations of NOA.- Genetic spectrum of NOA.- Differentiation between OA and NOA.- Imaging used in the evaluation of NOA.- Management of primary hypogonadism in men with NOA.- Management of secondary hypogonadism in men with NOA.- Follow-up and Monitoring of Adolescents with Delayed Puberty, Testicular Dysgenesis Syndrome.- Fertility restoration options for prepubertal boys undergoing gonadotoxic treatment.- The Role of Varicocele Repair in Patients with Nonobstructive Azoospermia.- Surgical approaches for sperm retrieval.- Predictors of Sperm Retrieval for Non-Obstructive Azoospermia.- Overview of the technical aspects in the lab.- Management of Non-Obstructive Azoospermia After Prior Failed Treatment.- Emotional and psychological impact of Non-Obstructive Azoospermia (NOA).- Summary of the Most Recent International Guidelines on Non-Obstructive Azoospermia.- Future of non-obstructive azoospermia (NOA).

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Book SynopsisDie Sexualgeschichte ist keine eigenständige Disziplin, sondern Teilaspekt natur-, geistes- und sozialwissenschaftlicher Fächer sowie häufiges Thema gesellschaftspolitischer Diskussionen. Florian G. Mildenberger zeigt historische Entwicklungen, gesellschaftliche Diskurse und Problemfelder von der Antike bis zur Gegenwart auf, beschreibt sie überblicksartig und stellt weitere Literatur für eigene Studien bereit.​Der Autor:Dr. Florian G. Mildenberger ist Professor am Institut für Geschichte der Medizin der Robert Bosch Stiftung in Stuttgart und forscht vorrangig zu Geschichte, Entstehung und Bedeutung heilkundlicher, sozialer und sexueller Subkulturen im 19./20. Jahrhundert.Trade Review“... Eine besondere Stärke ist, dass Florian Mildenberger zeigt, wie sich politische und medizinische Großereignisse, wie die Unabhängigkeit der USA, der Zusammenbruch des Ostblocks, die Einführung von Antibiotika oder der Antibabypille auf die Auslebbarkeit von Sexualitäten auswirkte ...” (Wolfgang Burgdorf, in: H-Soz-Kult, hsozkult.de, 12. Oktober 2020)“... Die Darstellungen des Bändchens sind überaus dicht und komprimiert angelegt, was der Intention, „[e]ine kurze Einführung“ zu gewährleisten ... und „Literaturhinweise zum Weiterlesen und Studieren“ (ebd.) zu bieten, dennoch mehr als gerecht wird ...” (Maximilian Römer, in: Sexuologie, Jg. 26, Heft 3-4, 2019)Table of ContentsSexualitäten im Wandel der Zeit – Antike, europäisches Mittelalter, von der Renaissance bis ins 19. Jahrhundert.- Sexualitäten zwischen Befreiung und Begrenzung (1850 bis 2000).- Sexualitäten in (Nord)Amerika, Afrika, Asien und Ozeanien.- Die neosexuelle Gegenwart.

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Book SynopsisThis book is on ovulation induction and controlled ovarian stimulation which is an integral part of most infertility therapies like intrauterine insemination and in vitro fertilization. It would deal with causes of anovulation and indications for ovarian stimulation. This book deals with basics as well as current and advanced practices. It provides a step by step protocol for ovarian stimulation. It gives a clear understanding of the science of reproductive endocrinology behind these stimulation protocols and roadmaps the latest therapies, defining their current relevance to treatment. Besides the practical guidance it also covers latest research work done in this field. In this day of information overload it is an attempt to integrate relevant information in a manner which can be applied in infertility practice in evidence based manner, making it rational, logical and rewarding for the reader.Table of ContentsPart I: Pre Stimulation Assessment and Interventions.- Chapter 1 Detection of Ovulation and Etiology of Anovulation- Pratima Mittal and Navdeep Kaur Ghuman.- Chapter 2 Evaluation Prior to Controlled Ovarian Stimulation- Narendra Malhotra, Jaideep Malhotra, Diksha Goswami Sharma, Shilpi Gupta, Neharika Malhotra Bora, Shally Gupta, and Garima Sharma.- Chapter 3 Therapeutic Intervention of Endometrial Pathology Before Ovarian Stimulation- Lakhbir K. Dhaliwal and Shalini Gainder.- Chapter 4 Obesity and its Impact on Ovarian Stimulation- Surveen Ghumman and Pinkee Saxena.- Part II: Controlled Ovarian Stimulation—Protocols.- Chapter 5 Oral Ovulogens in IUI and IVF- Sankalp Singh, Swati Singh, and C. Mohamed Ashraf.- Chapter 6 Ovarian Stimulation in IUI- Manju Puri and Richa Aggarwal.- Chapter 7 Protocols for Gonadotropin Use- Fessy Louis Thalakottoor.- Chapter 8 Human Menopausal Gonadotropin, Pure FSH, and Recombinant FSH—A Comparative Analysis- Sudha Prasad and Mona Dahiya.- Chapter 9 GnRH Agonists in Controlled Ovarian Stimulation- Hrishikesh D. Pai, Pritimala Bhalchandra Gangurde, Nandita P. Palshetkar, and Rishma Dhillon Pai.- Chapter 10 GnRH Antagonist in Ovarian Stimulation- Yakoub Khalaf and Sesh Kamal Sunkara.- Chapter 11 GnRH Agonist vs. Antagonist in ART - Madhuri Patil.- Chapter 12 Mild Stimulation Protocol- Nalini Mahajan and Shivani Singh.- Chapter 13 Individualising Ovarian Stimulation Protocols in ART- Pratap Kumar.- Chapter 14 Impact of Mutations and Polymorphisms of Gonadotrophins and Their Receptors on the Outcome of Controlled Ovarian Stimulation- Carlo Alviggi, Alessandro Conforti, and and Sandro C. Esteves.- Chapter 15 The Role of Androgens in Controlled Ovarian Stimulation- Jordana Hadassah Hyman and Ariel Revel.- Chapter 16 The Role of LH in Controlled Ovarian Simulation- Sandro C. Esteves and Carlo Alviggi.- Chapter 17 Ovulation Trigger-HCG vs. GnRH Agonist- Neeta Singh and Malti Madhu.- Chapter 18 The Pharmacoeconomics of Ovarian Stimulation- Jaideep Malhotra and Diksha Goswami Sharma.- Part III: Monitoring During Controlled Ovarian Stimulation.- Chapter 19 Endocrine Monitoring of ART Cycles- Neena Malhotra.- Chapter 20 Ultrasonography in Controlled Ovarian Stimulation- Shiri Shinar, Benny Almog, and Igal Wolman.- Part IV: The Endometrium and Luteal Phase.- Chapter 21 Effect of Ovarian Stimulation on the Endometrium- Manish Banker and Arati Gupte-Shah.- Chapter 22Luteal Support: What to Use When? - Sandeep Talwar.- Chapter 23 Endometrial Support Beyond Hormones- Mala Arora and Shilpa Gulati.- Part V: Pathology in Controlled Ovarian Stimulation.- Chapter 24 Prediction of Poor Responders and Current Concepts in Management- Gautam N. Allahbadia and Rubina Merchant.- Chapter 25 Premature Rise of Progesterone during Ovarian Stimulation- R.K. Sharma and Arti Kapoor.- Chapter 26 Empty Follicle Syndrome- Sandeep Karunakaran.- Chapter 27 Luteinizing Unruptured Follicle- Pikee Saxena.- Part VI: Controlled Ovarian Stimulation in Gynecological Disorders.- Chapter 28 Endometriosis—Surgical Management and Optimal Ovarian Stimulation Protocol for ART- Ramandeep Kaur, Urvashi Prasad Jha, Neema Sharma, Ritambara Agrawal, and Priyata Lal.- Chapter 29 Hyperprolactinemia- Abha Majumdar and Nisha Sharma Mangal.- Chapter 30 Polycystic Ovarian Syndrome and Response to Stimulation- Nandita P. Palshetkar, Hrishikesh D. Pai, Manisha Bhagat, and Rohan Palshetkar.- Chapter 31 Role of Laparoscopic Ovarian Drilling in Polycystic Ovarian Syndrome and its Effect on ART- Pankaj Talwar, Ashok K. Pillai, and Falahunisa Shaikh.- Chapter 32 Ovulation Induction in Hypogonadotrophic Hypogonadism- Umesh Nandani Jindal and Sheetal Jindal.- Chapter 33 Ovarian Stimulation Protocols in Fertility Preservation-Pankaj Talwar, Puneet Rana Arora, and Nalini Mahajan.- Chapter 34 Ovarian Stimulation in Cancer Patient- Sohani Verma.- Part VII: Negative Impact of Controlled Ovarian Stimulation.- Chapter 35 Epigenetics and Ovarian Stimulation- Jayant G. Mehta.- Chapter 36 Effect of Ovarian Stimulation Protocols on Oocyte and Embryo Quality- James Catt.- Chapter 37 Ovarian Hyperstimulation Syndrome—Can We Eliminate It as a Complication of ART?- Mala Arora and Ritika Arora.- Chapter 38 Multifetal Pregnancy Reduction- Shweta Mittal Gupta.

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Book SynopsisFirst published in 1919 as ''Diseases of Women'', Gynaecology by Ten Teachers is well established as a concise, yet comprehensive, guide within its field. The 21st Edition has been thoroughly updated by its latest team of ''teachers'', integrating clinical material with the latest scientific developments that underpin patient care. Each chapter is highly structured, with learning objectives, definitions, aetiology, clinical features, investigations, treatments and key point summaries and additional reading where appropriate. A key theme for this edition is ''professionalism'' and information specific to this is threaded throughout the text. KEY FEATURES Fully revised content is entirely refreshed and up to date for this 21st Edition, including the latest imaging and reproductive technologies and current guidelines for best practices Highly illustrated text supported and enhanced throughout by high-quality colour li

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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978-0521519526

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisA history of prenatal testing that shows it to be more complicated than a simple medical advance, bringing with it a host of questions about ethics and responsibility.

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Book SynopsisOur knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems.Table of ContentsList of Contributors xv 1 Anatomy of the Reproductive System 1Gheorghe M. Constantinescu 1.1 Male Genital Organs in Domestic Mammals 1 1.2 Female Genital Organs in Domestic Mammals 5 1.3 The Genital System in Domestic Mammals Species by Species 9 1.4 Genital Organs in Laboratory Mammals 35 References 56 2 Anatomy of Mammalian (Endocrine) Glands Controlling the Reproduction 59Gheorghe M. Constantinescu 2.1 The Hypothalamus Including the Hypophysis 59 2.2 The Cerebral Epiphysis 61 2.3 The Thyroid Gland 61 2.4 The Adrenal Glands 62 2.5 The Sexual Glands 63 2.6 The Liver 63 References 63 3 Models for Investigating Placental Biology 65Laramie Pence and Bhanu P. Telugu 3.1 Introduction 65 3.2 Classification of Placenta 66 3.3 Development of Human Placenta 69 3.4 Modeling Placental Development and Diseases of Placental Origin 73 3.5 Summary 82 References 82 4 Early Developmental Programming of the Ovarian Reserve, Ovarian Function, and Fertility 91Francesca Mossa, Siobhàn W. Walsh, Alex C.O. Evans, Fermin Jimenez-Krassel, and James J. Ireland 4.1 Introduction 91 4.2 Impact of Prenatal Environmental Challenges on Fetal Oogonia (Germ Cells) 92 4.3 Impact of Prenatal Environmental Challenges on Fetal Follicle/Oocyte Numbers (Healthy versus Atretic) and Oocyte Quality 94 4.4 Impact of Prenatal Environmental Challenges on the Ovarian Reserve (Total Number of Morphologically Healthy Follicles/Oocytes in Ovaries) in Offspring 95 4.5 Impact of Prenatal Environmental Challenges on Ovarian Function (e.g., Pituitary Gonadotropin Secretion, Ovarian Hormone/Growth Factor Production, Response to Gonadotropins, Follicle Development, Irregular Reproductive Cycles, and Ovulation Rate) in Offspring 98 4.6 Impact of Prenatal Environmental Challenges on Fertility (as Measured by Conception Rates, Fecundity, or Age at Puberty or Menopause) in Offspring 100 4.7 Summary and Conclusion 101 References 102 5 Small Non-Coding RNAS in Gametogenesis 109Lukasz Smorag and D. V. Krishna Pantakani 5.1 Small Non-Coding RNAs 109 5.2 Function of sncRNAs in Gametogenesis 109 Acknowledgment 119 References 119 6 The Ovarian Follicle of Cows as a Model for Human 127Marc-André Sirard 6.1 Introduction 127 6.2 A Similar Physiology of Folliculogenesis 128 6.3 Assisted Reproduction 131 6.4 Testing the Competence Hypothesis 136 6.5 Conclusion 136 References 136 7 Production of Energy and Determination of Competence: Past Knowledge, Present Research, and Future Opportunities in Oocyte and Embryo Metabolism 145Jason R. Herrick, Elena Silva, and Rebecca L. Krisher 7.1 Introduction 145 7.2 Measuring Metabolism 145 7.3 The Relationship Between Oocyte Metabolism and Quality 148 7.4 Embryo Metabolism 152 7.5 Metabolic Biomarkers 157 7.6 Toward Personalized Culture Media: Formulating Media for Specific Maternal Conditions 158 7.7 Summary 161 References 162 8 Signal Transduction Pathways in Oocyte Maturation 177François J. Richard, Nicolas Santiquet, Annick Bergeron, and Daulat Raheem Khan 8.1 Introduction 177 8.2 Phosphodiesterase 181 8.3 Gap Junction Communications 192 8.4 Metabolic Switch (AMPK) 193 8.5 Conclusion 198 References 198 9 Pig Models of Reproduction 213B.R. Mordhorst and R.S. Prather 9.1 Introduction 213 9.2 Early Embryonic Development 213 9.3 Oocyte Maturation 215 9.4 Fertilization 216 9.5 Tubouterine Contractility 216 9.6 Development to the Blastocyst Stage 216 9.7 Pregnancy and Developmental Programming 217 9.8 Puberty 222 9.9 Reproductive Disease 223 9.10 Summary 223 Acknowledgments 223 References 223 10 The Mare as an Animal Model for Reproductive Aging in the Woman 235Elaine M. Carnevale 10.1 Introduction 235 10.2 Ovarian Activity and Reproductive Cycles 236 10.3 The Follicle 238 10.4 Fertility 239 10.5 The Oocyte 240 10.6 Conclusions 242 References 242 11 Spotlight on Reproduction in Domestic Dogs as a Model for Human Reproduction 247Shirley J. Wright 11.1 Introduction 247 11.2 Dog Reproduction 255 11.3 Dog-Assisted Reproductive Technology 321 11.4 Dog Contraception 328 11.5 The Dog as a Model for Human Reproduction 328 11.6 Concluding Statements 332 Acknowledgments 333 References 333 12 Animal Models of Inflammation During Pregnancy 359Karen E. Racicot and Keith E. Latham 12.1 Introduction 359 12.2 Local Inflammation of the Pregnant Female Reproductive Tract 360 12.3 Systemic Inflammation During Pregnancy 361 12.4 Genetic Models and Cellular Manipulation to Study Inflammation During Pregnancy 365 12.5 Inflammation During Pregnancy and Offspring Disease 370 12.6 Perspectives and Conclusions 372 Acknowledgments 373 References 373 13 Practical Approaches, Achievements, and Perspectives in the Study on Signal Transduction in Oocyte Maturation and Fertilization: Focusing on the African Clawed Frog Xenopus laevisas an Animal Model 383Ken-ichi Sato 13.1 Introduction to Reproductive Biology of Frog Oocytes and Eggs 383 13.2 Practical Approaches 383 13.3 Achievements and Perspectives 395 Acknowledgments 396 Appendix 396 References 399 14 Prezygotic Chromosomal Examination of Mouse Spermatozoa 401Hiroyuki Watanabe and Hiroyuki Tateno 14.1 Introduction 401 14.2 Procedure of Sperm Chromosome Screening 402 14.3 Practical Use of SCS Before Fertilization 404 14.4 Conclusion 406 Acknowledgments 406 Addendum 406 References 406 15 Molecular and Cellular Aspects of Mammalian Sperm Acrosomal Exocytosis 409Florenza A. La Spina, Cintia Stival, Dario Krapf, and Mariano G. Buffone 15.1 Introduction 409 15.2 Structure of the Acrosome 409 15.3 Intermediate Stages of Exocytosis 412 15.4 Sperm Capacitation Prepare the Sperm to Undergo Acrosomal Exocytosis 412 15.5 Physiological Site for the Occurrence of Acrosomal Exocytosis 414 15.6 SNARES and Other Proteins from the Fusion Machinery 416 15.7 Hyperpolarization 417 15.8 Actin Cytoskeleton 417 15.9 Calcium 418 References 419 16 Sperm Chromatin Dynamics Associated with Male Fertility in Mammals 427Naseer A. Kutchy, Sule Dogan, Abdullah Kaya, Arlindo Moura, and Erdogan Memili 16.1 Introduction 427 16.2 Sperm Chromatin Structure Modulates Sperm Nuclear Shape and Function 429 16.3 The Bull Is a Suitable Model for the Study of Male Fertility in Humans 430 16.4 Conclusions and Prospects 430 Acknowledgments 431 References 431 17 Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development 435Jan Nevoral and Peter Sutovsky 17.1 Introduction 435 17.2 Milestones of Pronuclear Development 436 17.3 Nuclear Envelope, Nuclear Pore Complexes, and Nuclear Lamina Changes During Pronuclear Development 438 17.4 Molecular Mechanism of Paternal and Maternal Pronucleus Biogenesis 440 17.5 Role of UPS in Pronuclear Biogenesis 442 17.6 Posttranslational Modifications of Pronuclear Histones 443 17.7 Sirtuin Family Histone Deacetylases in Gametogenesis and Development 446 17.8 Clinical and Technological Considerations 447 17.9 Conclusions 450 Acknowledgments 450 References 450 18 Alterations of the Epigenome Induced by the Environment in Reproduction 467Zhao-Jia Ge, Shen Yin, and Heide Schatten 18.1 Introduction 467 18.2 Epigenetic Reprogramming 467 18.3 Environment and Epigenetic Alterations 470 18.4 Animal Models Used in Reproduction to Research Epigenetic Alterations Induced by the Environment 472 18.5 Effects of Environment on Epigenetic Modifications in Humans 475 18.6 Epigenetics and Assisted Reproductive Technology (ART) 475 18.7 Priorities for the Future 476 Acknowledgments 476 References 476 19 Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development 485Stoyan Petkov, Kristine Freude, Kaveh Mashayekhi, Poul Hyttel, and Vanessa Hall 19.1 Introduction 485 19.2 Current Status on the Pluripotent State in the Pig Embryo 489 19.3 Current Status of the Establishment of Porcine Embryonic Stem Cells (pESCs) 491 19.4 Current Status in Establishment of Porcine-Induced Pluripotent Stem Cells 494 19.5 Future Perspectives: Use of Global Profiling on Pluripotent Cells from Pig Embryo and Pluripotent Stem Cells 499 19.6 Discussion and Conclusions 501 Acknowledgments 502 References 502 20 Applications of Metabolomics in Reproductive Biology 509Ana Luiza Cazaux Velho, Rodrigo Oliveira, Thu Dinh, Arlindo Moura, Abdullah Kaya, and Erdogan Memili 20.1 Introduction 509 20.2 Metabolomics and Reproductive Biology 510 20.3 Metabolomics Studies in Large Animals as Models for Humans 513 20.4 Conclusions and Future Prospects 513 Acknowledgments 514 Conflict of Interest 514 References 514 21 Cryopreservation of Mammalian Oocytes 519Muhammad Anzar 21.1 Principles of Cryopreservation 519 21.2 Cryopreservation of Mammalian Oocytes 522 Acknowledgments 542 Abbreviations 543 References 543 Index 557

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Book Synopsis“My work offers a window into the darkest and lightest corners of people’s lives, into the extremes of human experience,” writes Dr. Chavi Eve Karkowsky in High Risk, her timely and unflinching account of working in maternal-fetal medicine—that branch of medicine that concerns high-risk pregnancies. Whether offering insight into the rise in home births, the alarming rise in America’s maternal mortality rate, or the history of involuntary sterilization, Karkowsky offers a window into all that pregnancy, labor, and birth can entail—birth and joy, but also challenge and loss—illustrating the complexity of reproductive life and the systems that surround it. With historical insight and journalistic verve, Karkowsky unpacks what is involved for women, for a family, and for us as a society; and explores what’s at risk when these aspects of medicine remain clouded in mystery and misinformation.Trade Review"Pregnancies don’t always end up happily ever after, even in the skilled hands of a maternal-fetal medicine physician like Karkowsky. . . . [S]he provides a great deal of helpful information, carefully explaining an alphabet soup of acronyms . . . [S]he spells out why some pre-existing conditions in pregnant moms can lead to problems. . . . It’s reassuring to know that maternal deaths are rare and that doctors try so hard to help at-risk moms and their babies meet the odds." -- Karen Springen, Booklist"In addition to graphic accounts of complications, Karkowsky also examines how pregnancy care is evolving—not always for the better.... Karkowsky urges better communication between doctors and nurses and doctors and patients, especially in conveying tragic news. She also makes frequent references to her own experiences as a wife and mother, subject to some of the risks she describes. A solid primer on pregnancy risks as well as a cogent plea for progress to make childbirth even less perilous." -- Kirkus Reviews"As a physician and mother expecting my second child, I found this book to portray pregnancy as the nuanced and poignant experience that it is. A compelling and engaging read." -- Dr. Leana Wen, physician, professor, and former President/CEO of Planned Parenthood"Dr. Karkowsky unflinchingly probes the expectations, precedents, myths, realities, and curveballs of modern pregnancy and delivery. This book is a significant contribution to the discourse about women’s health and medicine today." -- Danielle Ofri, MD, PhD, author of When We Do Harm"Profound, gripping, unsparing, and compassionate, High Risk offers a nuanced examination of issues that impact so many of us, from a perspective we almost never get to hear. This is an important book that shines a critical light on the medicine and systems surrounding pregnancy and birth." -- Rabbi Danya Ruttenberg, author of Nurture the Wow"What a gift to find a voice like Dr. Karkowsky's in the literary conversation around birth. Her humility, introspection, self-examination, and expertise is precisely what we need from our most highly trained specialists.… A fascinating dispatch from the front lines of high-risk obstetrics." -- Elisa Albert, author of After Birth"Dr. Karkowsky knows her subject from the inside, and shows us, both through her narratives and her wise reflections on them, just why such 'knowledge is powerful and painful and damaging, but it's also powerful and healing and wonderful.'… Every doctor, medical student, and prospective parent should read it." -- Terrence Holt, author of Internal Medicine"An edifying and utterly enthralling meditation on the joys and sorrows of being a doctor at the frontlines of high-risk pregnancies. Dr. Chavi Eve Karkowsky is a clinician who loves what she does, who grapples with tough decisions and who cares deeply about women’s reproductive health…This book should be mandatory reading for any woman who has been pregnant or considering pregnancy and everyone who provides health care to women.”" -- Randi H. Epstein, author of Aroused

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