Physiology Books

Book SynopsisDr. Arnold Katz's internationally acclaimed classic, Physiology of the Heart , is now in its thoroughly revised Fifth Edition, incorporating the latest molecular biology research and extensively exploring the clinical applications of these findings. In the single authored, expert voice that is this book's unique strength, Dr. Katz provides a comprehensive overview of the physiological and biophysical basis of cardiac function, beginning with structure and proceeding to biochemistry, biophysics, and pathophysiology in arrhythmias, ischemia, and heart failure. Emphasis is on the interrelationships of basic processes among the cell, cardiac muscle function, and the biophysics of contractile and electrical behavior. This edition includes new material on cell signaling and molecular biology.Table of ContentsPart One: STRUCTURE, BIOCHEMISTRY, AND BIOPHYSICS1: Structure of the Heart and Cardiac Muscle2: Energetics and Energy Production3: Energy Utilization (Work and Heat)4: The Contractile Proteins5: The Cytoskeleton6: Active State, Length-Tension Relationship, and Cardiac Mechanics7: Excitation-Contraction Coupling: Extracellular and Intracellular Calcium CyclesPart Two: SIGNAL TRANSDUCTION AND REGULATION8: Signal Transduction: Functional Signaling9: Signal Transduction: Proliferative Signaling10: Regulation of Cardiac Muscle Performance: Functional and Proliferative MechanismsPart Three: NORMAL PHYSIOLOGY11: The Heart as a Muscular Pump12: The Working Heart13: Cardiac Ion Channels14: The Cardiac Action PotentialPart Four: CLINICAL PHYSIOLOGY15: The Electrocardiogram16: Arrhythmias17: The Ischemic Heart18: Heart Failure

Read more less

Book SynopsisA classic title designed to be used as an instruction guide and a study guide, for laboratory courses in comparative vertebrate anatomy. Organisms include protochor-dates, lampry, dogfish shark, mud puppy, and cat.

Read more less

Book SynopsisThis workbook is packed with unique learning activities including Puzzle It Out - complete the crossword puzzles; Conceptualize in Color - color figures from the book; Lists for Learning - fill-in-the-blanks to compile lists; Make a Connection - unscramble words and then draw lines to connect each word to the appropriate statement.Table of ContentsPart I Foundation of the BodyChapter 1 Orientation to the Human BodyChapter 2 Chemistry of LifeChapter 3 CellsChapter 4 Human MicrobiomePart II Covering, Support, and Movement of the BodyChapter 5 TissuesChapter 6 Integumentary SystemChapter 7 Bones & Bone TissueChapter 8 Skeletal SystemChapter 9 JointsChapter 10 Muscular SystemPart III Regulation and Integration of the BodyChapter 11 Nervous SystemChapter 12 Sense OrgansChapter 13 Endocrine SystemPart IV Maintenance of the BodyChapter 14 BloodChapter 15 HeartChapter 16 Vascular SystemChapter 17 Lymphatic & Immune SystemsChapter 18 Respiratory SystemChapter 19 Urinary SystemChapter 20 Fluid, Electrolyte, & Acid-Base BalanceChapter 21 Digestive SystemChapter 22 Nutrition & MetabolismPart V ContinuityChapter 23 Reproductive SystemsChapter 24 Pregnancy & Human DevelopmentChapter 25 Heredity

Read more less

Book SynopsisA book about how people and machines work together, and how we design machines to replicate and amplify what we can do ourselves.Trade Review"Vogel writes with his typical, easy-as-pi style that epitomizes his intense curiosity for all things round. Gear up to read topics revolving around tools, toys, machines, and even animals. Ever the spokesman for experiments, Vogel goes full circle by ending with an appendix filled with DIY physical models. Whether you're a tinkerer in the garage, an inquisitive self-educator, or a budding biomechanist, this page-turner will round out your knowledge of circular motion." --Anna Ahn, Harvey Mudd College "A revolution about revolutions, Why the Wheel Is Round is Vogel's microhistory of humans doing what doesn't come naturally: creating and powering rotational tools and machines. To make muscle-powered rotary machinery -- querns, bow drills, whims, lathes, and horse ferries -- requires the invention of axels, cranks, and ropes. How this clever technology works, and why it works the way it does, is revealed clearly through the lens of biomechanics. Vogel is fascinated by spins, turns, and twists, and his enthusiasm for the artifacts around us is more than infectious. He incites an urge to invent and build, and, fortunately, includes instructions for doing so. Happiness runs in a circular motion." --John Long, author of Darwin's Devices: What Evolving Robots Can Teach Us about the History of Life and the Future of Technology "Reading this book, I found myself being pulled along by the curiosity of Vogel as he connects the power provided by the muscles of humans and animals with the immense variety of rotating objects invented over the course of human history. Despite the book's title, wheels are only one part of the story. Firmly grounded in Vogel's deep understanding of physical principles, the book is as informative as it is entertaining." --Richard Marsh, Brown University

Read more less

Book Synopsis

Read more less

Book SynopsisAlmost all bodily functions are dependent on activity of the autonomic nervous system from the cardiovascular system, the gastrointestinal tract, the evacuative and sexual organs, to the regulation of temperature, metabolism and tissue defence. Balanced functioning of each aspect of this system is an important basis of our life and well-being. In this long-awaited second edition, the author, a leading figure in this field, provides an up-to-date and detailed description of the cellular and integrative organization of the autonomic nervous system, covering both peripheral and central aspects. The book exposes modern neurobiological concepts that allow us to understand why this system normally runs so smoothly and why its deterioration has such disastrous consequences. This broad overview will appeal to researchers and advanced undergraduate students of the various biological and medical sciences studying how the autonomic nervous system works and to clinicians and physical therapists whose practice involves systems dependent on autonomic functions.Trade Review'This is the ultimate resource for anyone interested in autonomic neurosciences. Professor Jänig has tastefully updated a classic book which manages to distill a vast body of knowledge that will continue to be cherished by students as well as established scientists.' Kalyanam Shivkumar, Professor of Medicine, The University of California, Los Angeles (UCLA), and President, International Society for Autonomic Neuroscience (ISAN 2022)'Wilfrid Jänig has produced an outstanding synthesis of the state of knowledge of the autonomic nervous system (ANS). The book is far more than a summary of knowledge; Jänig has drawn out important principles from experimental work and his deep understanding of physiology. He shows how the ANS, in partnership with endocrine hormones, purposefully maintains cells, tissues, and organs in their optimal functional states. The book is beautifully illustrated, especially with diagrams of autonomic circuits. Also very helpful are the conclusions paragraphs at the ends of chapters. The book is essential reading for the seriously engaged physiologist and physician.' John B. Furness, Professor of Anatomy and Physiology, The University of Melbourne and The Florey Institute of Neuroscience and Mental Health'This is the 'Workshop Manual' of how the autonomic nervous system works. The integrative aspect of this book is quite superb. Jänig has avoided the traditional, and unhelpful, silo approach where bodily systems are separated in distinct chapters. This is inconsistent with how the body works. This new edition leaves no 'autonomic' stone unturned, covering endplates to emotion, credits the historical facts that have stood the test of time but kicks those into touch that have not. So pleasing was to see that the book challenges old/outdated dogma and sets the facts straight by reviewing the most current evidence. I know that my copy of this book will spend its life being read and not on a shelf; it will be poured over by professors and students alike. The illustrations require a mention: they are exceptional - clear, concise, and comprehensive. I believe this book will put the autonomic nervous system front and center in the field of neuroscience.' Julian F.R. Paton, Professor of Translational Physiology, University of Auckland, New ZealandTable of ContentsForeword to the Second Edition Elspeth McLachlan; Foreword to the First Edition Elspeth McLachlan; Preface; List of abbreviations; Introduction: The autonomic nervous system and the regulation of body functions; Part I. The Autonomic Nervous System: Functional Anatomy and Interoceptive Afferents: 1. Functional anatomy of the peripheral sympathetic and parasympathetic nervous system; 2. Interoceptive afferent neurons and autonomic regulation with special emphasis on the viscera; Part II. Functional Organization of the Peripheral Autonomic Nervous System: 3. The final autonomic pathway and its analysis; 4. The peripheral sympathetic and parasympathetic pathways; 5. The enteric nervous system; Part III. Transmission of Signals in the Peripheral Autonomic Nervous System: 6. Impulse transmission through autonomic ganglia; 7. Mechanisms of neuroeffector transmission; Part IV. Representation of the Autonomic Nervous System in Spinal Cord, and Lower Brain Stem: 8. Anatomy of central autonomic systems; 9. Spinal autonomic systems; 10. Regulation of organ systems by the lower brain stem; Part V. The Centers of Homeostasis in the Mesencephalon and Hypothalamus and their Telencephalic Control: 11. Integration of autonomic regulation in upper brain stem and limbic-hypothalamic centers: a summary; Epilogue The autonomic system in future research: some personal views; Index.

Read more less

Book SynopsisTried and true - build A&P confidence every step of the way! Here's the approach that makes A&P easier to master. A student-friendly writing style, superb art program, and learning opportunities in every chapter build a firm foundation in this must-know subject to ensure success.Table of Contents Chapter 1 Organization and General Plan of the Body Chapter 2 Some Basic Chemistry Chapter 3 Cells Chapter 4 Tissues and Membranes Chapter 5 The Integumentary System Chapter 6 The Skeletal System Chapter 7 The Muscular System Chapter 8 The Nervous System Chapter 9 The Senses Chapter 10 The Endocrine System Chapter 11 Blood Chapter 12 The Heart Chapter 13 The Vascular System Chapter 14 The Lymphatic System and Immunity Chapter 15 The Respiratory System Chapter 16 The Digestive System Chapter 17 Body Temperature and Metabolism Chapter 18 The Urinary System Chapter 19 Fluid-Electrolyte and Acid-Base Balance Chapter 20 The Reproductive Systems Chapter 21 Human Development and Genetics Chapter 22 An Introduction to Microbiology and Human Disease Appendices Glossary Index

Read more less

Book SynopsisThis is an authoritative overview for anyone encountering Postural Orthostatic Tachycardia Syndrome (POTS) - a dysfunction of the autonomic nervous system resulting in diverse symptoms experienced in an upright position that are relieved by lying down - and other types of acquired dysautonomia. It provides essential information on the symptoms, diagnosis and treatment in children and young people. Post-viral syndromes can be extremely difficult to manage and the average individual spends two to three years accessing appropriate diagnosis. This book provides necessary information for parents and healthcare professionals on identifying POTS and other post-viral dysautonomia, the most common triggers, appropriate intervention and successful multi-disciplinary management in both short and long term situations. It also includes helpful tips and coping strategies for managing the syndrome at home and in educational and clinical settings.Trade ReviewKelly McCracken Barnhill has created an easy-to-understand handbook that is suitable as a reference resource for medical professionals, parents, and patients. She has been successful in demystifying this complex syndrome through the use of well-researched explanations of up-to-date testing and discussions of treatment options presented in the crucible of first hand patient accounts. The reader will find this an invaluable guide through the maze of dysautonomia. -- Ainsley R Glenn, Founding Director, Dysautonomia Advocacy FoundationTable of ContentsForeword by Fletcher Barnhill. Preface. 1. Background and Emerging Diagnosis. 2. Putting the Pieces Together: Making Sense of the Nonsensical. 3. Accessing Appropriate Diagnosis (And what does that truly look like?). 4. Appropriate Medical Treatment and Intervention. 5. Appropriate Supportive Therapeutic Intervention One: Diet. 6. Appropriate Supportive Therapeutic Intervention Two: Nutrition. 7. Appropriate Supportive Therapeutic Intervention Three: Physical Therapy, Reconditioning and Rehabilitation. 8. Appropriate Supportive Therapeutic Intervention Four: Counseling and Therapy. 9. Fostering Coping Strategies and Stress Management, for the Entire Family. 10. Navigating the Necessities of Life: Accommodations for Education and Activities. 11. Case Reports, Stories and Studies. 12. Case Study - How to Be a Zebra. Next Steps. Appendices. Resources for family, individual, and community support. References.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisGain insight on diseases and treatment options for better patient care!Explore human diseases and disorders…from a patient’s perspective!Join the generations of students who have relied on this popular text to introduce them to common human diseases and disorders. Its concise, well-organized approach makes learning about the conditions nearly painless! You’ll better understand your patient’s condition and more easily form a plan of care. And it emphasizes the condition from the perspective of the patient, so you can empathize with the patient as you’re providing care. You’ll want to keep this book long after you’ve finished your program!Access more online.Redeem thecode inside new, printed texts to gain access to a wealth of resources online, including videos, animations, and chapter review podcasts.Trade ReviewSee what students are saying about the previous edition…Save it for your medical library. “Great textbook. Made a class I thought was going to be dreadfully boring into one of my favorite classes. You'll learn a lot more about your health and the health of your family. Definitely hanging on to this one.”- K., Online Reviewer;Great Content. “This was required for my class, but I’m really enjoying the content. Great information on sign/symptoms, causes, etiology, treatment and prevention of so many diseases.”- Emily, Online Reviewer;Five Stars. “Great book for class. Clear concise wording. Straight to the point, easy to follow and read.”- Joyce, Online Reviewer.Table of Contents 1. The Disease Process 2. Integrative Medicine and Complementary Therapies 3. Pain and Its Management 4. Infectious and Communicable Diseases 5. Cancer 6. Congenital Diseases and Disorders 7. Mental Health Diseases and Disorders 8. Skin Diseases and Disorders 9. Musculoskeletal Diseases and Disorders 10. Nervous System Diseases and Disorders 11. Endocrine System Diseases and Disorders 12. Cardiovascular and Lymphatic System Diseases and Disorders 13. Respiratory System Diseases and Disorders 14. Digestive System Diseases and Disorders 15. Urinary System Diseases and Disorders 16. Reproductive System Diseases and Disorders 17. Eye and Ear Diseases and Disorders Appendix 1. Diagnostic Procedures Appendix 2. Abbreviations Glossary

Read more less

Book SynopsisThis first-of-its-kind text integrates the 3 Ps - pathophysiology, pharmacology, and physical assessment - into an integrative whole that reflects the real-world of how students learn and nurses practice. This groundbreaking approach promotes a deeper understanding of these three essential and often challenging content areas.Table of Contents Introduction: Foundations of Integrative Practice I. Adult 1. Hypertension 2. Diabetes Mellitus 3. Obesity 4. IBS and IBD 5. Myocardial Infarction Case Study 1 (Adult): Glaucoma II. Maternity 6. Hypertensive Disorders of Pregnancy 7. Gestational Diabetes 8. High-Risk Pregnancy 9. Hyperemesis Gravidarum Case Study 2 (Maternity): Vaginal Bleeding III. Newborn 10. Hyperbilirubinemia in the Newborn 11. Congenital Heart Disease 12. : Respiratory Conditions 13. Prematurity and Newborn Conditions Case Study 3 (Newborn): Nutrition IV. Pediatrics 14. Asthma 15. Allergic and Hypersensitivity Disorders 16. Gastroesophageal Reflux Disease 17. Traumatic Brain Injury 18. Otitis Media Case Study 4 (Pediatrics): Acute Lymphoblastic Leukemia V. Geriatric 19. Healthy Aging 20. Heart Failure 21. Pneumonia 22. Osteoarthritis and Rheumatoid Arthritis 23. Chronic Kidney Disease Case Study 5 (Geriatric): Osteoporosis VI. Mental Health Disorders across the Lifespan 24. Altered Cognitive Function 25. Anxiety and Depression 26. Psychotic Disorders 27. Substance Abuse Disorders Case Study 6 (Mental Health): ADHD Appendix: Answers to Review Questions

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThe first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.Table of ContentsPreface; Part I. General Principles of Genetics and Genomics: 1. Methods in complex trait analysis: mapping the genetic basis of sleep using model organisms Amelie Baud and Jonathan Flint; 2. Linkage and associations Elizabeth J. Rossin and Benjamin M. Neale; 3. Genome-wide association study approaches to sleep phenotypes Patrick Sleiman, Michael March and Hakon Hakonanson; Part II. Genetics of Sleep and Circadian Rhythms: 4. Genetic epidemiology of sleep and sleep disorders Christer Hublin and Jaakko Kaprio; 5. Drosophlia model systems for genetic sleep research Stephane Dissel and Paul J. Shaw; 6. Caenorhabditis elegans and zebrafish in sleep research David A. Prober and David M. Raizen; 7. Optogenetic control of arousal neurons Antoine Adamantidis, Matthew E. Carter and Luis De Lecea; 8. Prostaglandin D2 in the regulation of sleep Yoshihiro Urade and Michael Lazarus; 9. Astroglial regulation of sleep Marcos G. Frank; 10. The role of metabolic genes in sleep regulation Matthew S. Thimgan and Karen D. Schilli; 11. A systems biology approach for uncovering the genetic landscape for multiple sleep-wake traits Peng Jiang, Andrew Kasarskis, Christopher J. Winrow, John J. Renger and Fred W. Turek; 12. Genetic control of the circadian pacemaker Ethan Buhr and Joseph S. Takahashi; 13. Epigenetic basis of circadian rhythms and sleep disorders Irfan A. Qureshi and Mark F. Mehler; Part III. Sleep Physiology and Homeostasis: 14. Genetics of sleep and EEG Thomas Curie and Mehdi Tafti; 15. Genetic interaction between circadian and homeostatic regulation of sleep Valérie Mongrain and Paul Franken; 16. Genetic approaches to understanding circadian entrainment Till Roenneberg and Karla V. Allebrandt; 17. Animal models for cognitive deficits induced by sleep deprivation Laurent Seugnet and Paul Salin; 18. Individual differences in sleep duration and responses to sleep loss Devon A. Grant and Hans P. A. Van Dongen; 19. Clock polymorphisms associated with human diurnal preference Simon N. Archer and Derk-Jan Dijk; 20. Sleep and long-term memory storage Jennifer H. K. Choi and Ted Abel; 21. Sleep and synaptic homeostasis Chiara Cirelli and Giulio Tononi; Part IV. Insomnias: 22. Heritability and genetic factors in chronic insomnia Yves Dauvilliers and Charles M. Morin; Part V. Narcolepsy and Hypersomnias: 23. HLA and narcolepsy Katsushi Tokunaga and Makoto Honda; 24. Orexin (hypocretin) and narcolepsy Takeshi Sakurai and Seiji Nishino; 25. Gene-wide association studies in narcolepsy Hyun Hor; 26. Genetic disorders producing symptomaric narcolepsy Seiji Nishino and Takashi Kanbayashi; 27. Genetics of recurrent hypersomnia Michael Billiard, Rosa Periata-Adrados and Mehdi Tafti; Part VI. Sleep-related Breathing Disorders: 28. Linkage and candidate gene studies of obstructive sleep apnea Annette C. Fedson, Thorarinn Gislason and Allan I. Pack; 29. Genomic mutations and genotype-phenotype in pediatric sleep-related breathing disorders Leila Kheirandish-Gozal and David Gozal; Part VII. Circadian Rhythm Sleep Disorders: 30. Genetic of familial advanced sleep phase Suet Ying Chong, Louis J. Ptacek and Ying-Hui Fu; 31. Delayed sleep phase disorder, circadian genes, sleep homeostasis and light sensitivity Simon N. Archer and Derk-Jan Dijk; Part VIII. Parasomnias and Sleep-related Movement Disorders: 32. Family and genome-wide association studies of restless legs syndrome Eva C. Schulte and Juliane Winkelmann; Part IX. Psychiatric and Medical Disorders: 33. Circadian clock genes and psychiatric disorders Marc Cuesta, Nicholas Cermakian and Diane B. Boivin; 34. Genetics of autosomnal dominant nocturnal frontal lobe epilepsy Keivan Kaveh Moghadam and Giuseppe Plazzi; Part X. Medication Effects: 35. Gene therapy for sleep disorders Dheeraj Pelluru, RodaRani Konadhode, Carlos Blanco-Centurion, Meng Liu and Priyattam J. Shiromani; Index.

Read more less

Book SynopsisInformation is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schrödinger''s What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our current biological understanding.Trade Review'The essence of the book is in its title. The DNA structures and topology are described so clearly that the reader perceives these intricacies as pure evolutionary elegance, and understands WHY it is only in its balance of stability and agility that life could have started its journey. This book explains how DNA has become the fascinating prism, made of a fabric of complexity and information, into which the living reflects itself. My opinion is passionate because I have been thinking about the same problems for decades, and here I find many of the answers. Especially: what makes DNA so unique? It is a text that I keep reading over again.' Ernesto Di Mauro, IBPM, National Research Council, Rome'In What Is Life? Schrödinger conjectured that, in animate matter, order is derived from order, foreshadowing the discovery of DNA structure. Why DNA? is about this molecule and its dual information content - in linear genetic code and in thermodynamics of three-dimensional DNA structures. It addresses how DNA's intrinsic order led to complex, highly ordered living organisms, in a world that strives towards disorder. Why would DNA supplant RNA in carrying hereditary information during biological evolution? Why did multicellular organisms emerge, since natural selection favours the fittest, such as simple bacteria? What is complexity, and what has it to do with Bayesian logic? How do complexity, information and energy interrelate? This is a succinct discourse on Schrödinger's question, expanding from molecular interactions and genome cooperation to ecological systems and societal evolution. A must-read for biology scholars, and anyone interested in life's origins, biological evolution and the interface of biology and physics.' Georgi Muskhelishvili, Agricultural University of Georgia, TbilisiTable of ContentsAcknowledgements; Preface; 1. The perennial question; 2. The nature of information – information, complexity and entropy; 3. DNA – the molecule; 4. The evolution of biological complexity; 5. Cooperating genomes; 6. DNA, information and complexity; 7. Origins; 8. The complexity of societies; 9. Why DNA – and not RNA?; General reading and bibliography.

Read more less

Book SynopsisThis completely revised edition provides a synthesis of the forces that shaped the evolution of the human growth pattern, the biocultural factors that direct its expression, the intrinsic and extrinsic factors that regulate individual development, and the biomathematical approaches needed to analyze and interpret human growth. After covering the history, philosophy and biological principles of human development, the book turns to the evolution of the human life cycle. Later chapters explore the physiological, environmental and cultural reasons for population variation in growth, and the genetic and endocrine factors that regulate individual development. Using numerous historical and cultural examples, social-economic-political-economic forces are also discussed. A new chapter introduces controversial concepts of community effects and strategic growth adjustments, and the author then integrates all this information into a truly interactive biocultural model of human development. This reTable of ContentsIntroduction; 1. Background to the study of human growth; 2. Basic principles of human growth; 3. The evolution of human growth; 4. Evolution of the human life cycle; 5. Growth variation in living human populations; 6. Genetic and neuroendocrine regulation of human growth; 7. What makes people grow? Love, hope, community effects, and strategic growth in the context of environmental factors influencing human development; 8. A biocultural view of human growth; Glossary; References; Index.

Read more less

Book SynopsisThis well-established and acclaimed textbook introducing the rapidly growing field of nerve and muscle function has been completely revised and updated. Written with undergraduate students in mind, it begins with the fundamental principles demonstrated by the pioneering electrophysiological experiments on cell excitability. This leads to more challenging material recounting recent discoveries from applying modern biochemical, genetic, physiological and biophysical, experimental and mathematical analysis. The resulting interdisciplinary approach conveys a unified contemporary understanding of nerve and skeletal, cardiac and smooth muscle function at the molecular, cellular and systems levels. Emphasis on important strategic experiments throughout clarifies the basis for our current scientific views, highlights the excitement and challenge of biomedical discovery, and suggests directions for future advances. These fundamental ideas are then translated into discussions of related disease conditions and their clinical management. Now including colour illustrations, it is an invaluable text for students of physiology, neuroscience, cell biology and biophysics.Trade Review'Huang has taken on the mammoth task of bringing the book up-to-date and has succeeded in maintaining the enthusiastic and eminently readable approach of Keynes and Aidley, who created one of the greatest physiology books covering the crucial areas of nerve and muscle. The fascinating historical perspectives on the discovery of membrane potentials, the transmission of nerve impulses and their molecular basis are essential reading for students of medicine and physiology with a curiosity about scientific methods, and progress.' Michael A. Ferenczi, Imperial College London'...a beautifully written gem. It is clearly illustrated, and it makes one of the most difficult areas of biology completely accessible. It should find its way onto the bookshelves of electrophysiologists everywhere and any students who aspire to master one of the most exciting areas of modern biology.' Denis Noble, University of Oxford'This classic textbook on the fundamental biophysics and physiology of nerve and muscle remains an unparalleled source of knowledge that has served the scientific field for decades. Prof. Huang elegantly manages to update this edition with recent findings within this broad field continuing the excellence that characterizes this work.' Thomas Holm Pedersen, University of Aarhus, Denmark'Professor Christopher Huang has updated and significantly broadened the scope and the translational endpoints of the classical textbook of Integrative and Cell Physiology Keynes & Aidley's Nerve and Muscle. The result is a comprehensive, well planned, logically presented and extensively referenced monograph. Based on the text and supporting figures, it builds on the strengths of the parent textbook while also providing new in-depth coverage of recent advances in neurophysiology as well as skeletal and cardiac muscle electrophysiology and contractility. The internationally recognized research accomplishments of Professor Huang on key cell physiology mechanisms of the heart and skeletal muscle form the basis of very informative material concerning cardiac rhythm disturbances and some aspects of exercise physiology and aging. This textbook will serve as a valuable resource for undergraduates, graduate students, as well as both basic science and clinical faculty members in Life Sciences.' Wayne Giles, University of Calgary, CanadaTable of ContentsPreface; Acknowledgements; List of abbreviations; 1. Structural organization of the nervous system; 2. Resting and action potentials; 3. Background ionic homeostasis of excitable cells; 4. Membrane permeability changes during excitation; 5. Voltage-gated ion channels; 6. Cable theory and saltatory conduction; 7. Neuromuscular transmission; 8. Synaptic transmission in the nervous system; 9. The mechanism of contraction in skeletal muscle; 10. The activation of skeletal muscle; 11. Excitation-contraction coupling in skeletal muscle; 12. Contractile function in skeletal muscle; 13. Cardiac muscle; 14. Ion channel function and cardiac arrhythmogenesis; 15. Smooth muscle; Further reading; References; Index.

Read more less

Book Synopsis

Read more less

Book SynopsisIn this book, the science of anthropometry, which deals with measurements of human size, shape and proportion, is examined in the context of obesity and overweight, common problems in developed countries and developing countries alike. An estimated 39% of the world''s adult population were overweight and 13% were obese over the past 3 decades, and these problems can cause diseases like type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and several cancers. While body mass index (BMI) is commonly used as a health risk phenotype, it has several limitations because BMI does not accurately depict different components of body composition and is therefore unable to predict the prognostic effect of individual tissues. Other anthropometric measurements, such as waist circumference (WC), waist to hip ratio (WHR), and waist to height ratio (WHtR) each have their advantages and disadvantages. As such, in Chapter 1, different novel anthropometric parameters and cardiovascular risk factors among obesity adults are compared and evaluated. Chapter 2 describes a study of children aged 0-12 years conducted in the Middle Senegal River Valley (MISOES) in 1957-1958. This study was based on representative samples of children in urban and rural areas and included measurements of weight, height, arm circumference, and more. These measurements were compared with American standards and showed an overwhelming anthropometric deficit compared with standards. This study is examined in the context of other studies conducted in the region as well as in connection with economic development in the valley. Chapter 3 describes the various methods of assessing body fat and their application for obese individuals to predict the risk of Coronary Heart Disease (CHD), and Chapter 4 reviews the effect of different modalities of physical exercise on anthropometric measurements and body composition in different populations of older adults.

Read more less

Book SynopsisBiological Action of Low Doses of Radiation - A Novel View on the Problem

Read more less

Book SynopsisSeveral years have passed since the sequencing of the human genome and what might be called "the post-genomic era" has begun. Of course, there are many different genomes and the term "post-genomic" does not necessarily imply the human genome. However, it is the data encoded in the human genome that hold the promise to be of practical importance in a wide range of biomedical applications. The sequencing and preliminary annotations of the human genome provided an incredible amount of the raw, largely unprocessed information. Coupled with the millions of publications on human physiology already available in public databases, it is clear that certain informational strategies should be adopted for the retrieval, analysis and representation of these data. Among biological sciences, bioinformatics is a specific branch that deals with managing complexities in the biological information. However, the bioinformatics is in no way restricted to the compilation of large databases or elaboration of sophisticated software. The methods of bioinformatics can greatly assist the generation of productive hypotheses that allow subsequent experimental testing followed by confirmation or disapproval. The main idea behind the present volume is not worrying about the steadily growing amounts of biomedical information or about the relative quality of it. This volume, as well as the entire book series, is based on the purpose-oriented attitude: how to make a good use of this information in particular research projects.

Read more less

Book SynopsisChild nutrition physiology is the nutritional physiology of children aged 2-12 years. This book presents recent advances in the critically important field.

Read more less

Book SynopsisWhite matter is one of the three main solid components of the central nervous system. White matter tissue of the freshly cut brain appears white to the naked eye because of being composed largely of lipid. The other two components of the brain are grey matter and substantia nigra. This handbook presents the latest research in the field.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThis book presents new research in the study of oxidative stress. Topics discussed include pharmacological treatments in myocardial ischemia-reperfusion injury; oxidative stress in neurodenegerative disorders, hyptertension, and the cardiovascular system; the role of antioxidant supplementation in ischemic stroke; mitochondria at the crossroads of cancer and oxidative stress; and the influence of aerobic exercise training on post-prandial oxidative stress.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThis will undoubtedly be a great reference source for a large number of readers interested in bone medicine. This book explores not only the current state of knowledge, but also the newest research grounds and discoveries related to bone loss. These include novel pathophysiological research including the impact of chronic kidney disease, heart failure, diabetes and cancer disease on bone loss and strategies for possibly improving individuals who suffer from bone loss. This volume seeks to update interested readers on the latest advances in the uncharted territory and relatively new field of bone loss medicine.

Read more less

Book SynopsisFever is a centrally regulated thermoregulatory response leading to a rise of body core temperature. This book presents current research in the study of the types, treatment and health risks of fevers. Topics include the African Swine Fever virus pathogenesis and vaccine development; diagnosis of acute or obscure and prolonged febrile illnesses in adult patients; fevers of unknown origin in internal medicine; experimental fever and the role of acting neuropeptide mediators; fevers of intermediate duration; metabolic features of endothelium in hemorrhagic fever with renal syndrome; rat bite fever; non-local modelling of insect borne diseases; and treatment and drug resistance in cholera.

Read more less

Book SynopsisIn this book, the authors present current research in the study of the types, symptoms and treatments for fistulas and fissures. Topics include pancreatic fistulas; cutaneous advancement flap combined with tailored lateral internal sphincterotomy for chronic anal fissures; management of congenital fistulae; foot fissures in patients with diabetes; dialysis access-associated steal syndrome; anal fissures; advantage of surgical treatment for intracranial dural arteriovenous fistulas; pathogenesis of perianal fistulas in Crohn''s disease; setons in treatment of anal fistulas; biliary fistulas; and arm fistulae and their creation.

Read more less

Book SynopsisThe study of phenomena that occur during sleep has always aroused a great interest in various fields of human knowledge, both in religion and in philosophy, as well as in science. Hippocrates and Aristotle conducted different studies and observations on sleep and dreams, focusing on the changes that affect the state of consciousness between the waking and sleeping states. Freud even started from the observations and interpretation of dreams in the foundation of the psychoanalytic method. After the introduction of the electroencephalogram (EEG) by Hans Berger (1929), the beginning of modern sleep medicine began. Currently, the scientific literature in this field is very vast, gathering different aspects of many medical specialties, mainly including psychiatry, neurology, pneumology, cardiology, internal medicine, and others. Precisely because of this broad extension, it is not completely explorable by clinicians and is not always adequate for their needs.

Read more less

Book SynopsisIn this book, the authors present topical research in the study of the morphology, biomechanics and clinical implications of trabecular and cortical bone. Topics discussed include trabecular bone biomechanics and morphology; cortical bone as an enduring depot of bone-seeking contaminants and the evaluation of cortical bone resportion rate on the basis of a contaminant (90SR) measurement in humans; evaluation of apparent stress and strain at fracture of human trabecular bone under quasi-static compression load using micro-CT finite elements simulation; application of computational modelling to predict the effect of exercise on whole bone strength; advancements in cortical bone imaging; morphology of the pelvis (acetabulum) and femur; the release kinetics of bone morphogenetic proteins from demineralised cortical bone grafts; and preservation of cortical bone in oral and maxillofacial surgery procedures.

Read more less

Book SynopsisThis book covers human female biology, how the menstrual cycle is controlled, how steroidogenesis is controlled and how the follicle and the egg are formed. This book covers male biology, and how steroid hormones are made, and how sperm are synthesised and matured. Then this book covers sex biology, such as how the brain deals with libido and sexual images, and how the brain controls erection and ejaculation. This book deals with how sperm are matured upon intercourse, how fertilisation takes place, and how the fertilised embryo is matured and implants in the uterus. The subjects of sexuality and homosexuality, chromosome disorders and hydatidiform moles are carefully discussed and considered. Sexual maturation of the foetus during pregnancy is carefully considered. This book carefully describes puberty, adrenarche and menarche. The subject of menopause is carefully considered. The subject of major bacterial and viral and sexual diseases is carefully considered as is the subject of reproductive cancers. In writing this book, care has been taken to update everything and check out the information available on medline and on the internet. This is a textbook for undergraduates, medical students and graduates describing all the details of human reproduction. It is also the only up-to-date book on the market. Having examined a total 70 books on human reproduction, obstetrics and gynaecology, they all, with no exceptions, include mostly out-of-date science. This is corrected in this book. This book is also a monograph for reproductive biology scientists, covering all the most recent findings in this field. It can also be sold as a general obstetrics and gynaecology information source for use by physicians, the general public and in libraries. This is a unique one-of-a-kind reference on human reproduction.

Read more less

Book SynopsisThe primary function of appetite is to control adequate energy intake in order to meet an organism''s metabolic requirements. The interplay between hunger, appetite stimulation and food intake is tightly regulated by the central nervous system and conditioned by numerous inherently biological as well as acquired social and cultural phenomena. Appetite is closely linked to individual behaviour, thereby affecting energy intake as well as qualitative food structure and represents a basis for possible therapeutic intervention in individuals with impaired appetite regulations. This book presents several perspectives on appetite regulation in humans and animal models. The importance of understanding altered appetite regulation in cancer is highlighted as well as the effects of exercise on appetite. Finally, this book also presents new research into the role of genetic variability in ghrelin in dietary composition.

Read more less

Book SynopsisContractions of vertebrate skeletal and cardiac muscles are controlled by Ca2+ signalling through the troponin complex in the sarcomeres, which are the contractile machinery consisting of interactive myofilaments. Since the abundance of troponin sub-unit proteins in myocytes and their muscle-specific expression, troponin I (TnI) and troponin T (TnT) have been broadly applied as serum biomarkers for the clinical diagnosis of acute myocardial infarction and other heart and muscle injuries. Intensive research from protein structure to genetic diversity to post-translational modification and pathological mutations has comprehensively established the molecular structure of troponin. The advanced knowledge gained from basic research of troponin allows for a better understanding of the current methodology for troponin-based diagnostic applications. To help clinicians, diagnostic laboratory staff and methodology developers, this book provides comprehensive yet concise summaries of the current knowledge cover a broad range of topics including a detailed review of the structural features and adaptive modifications of troponin subunits and impacts on immunological detections; a comprehensive summary of the evolution of troponin assays; an evaluation of current assay platforms, quality specifications for cardiac troponin assays; the use of high-sensitivity cardiac troponin assays; electrochemical strategies for the detection of cardiac troponins; cardiac troponins in the evaluation of myocardial damage during and post percutaneous coronary interventions; troponin as markers of myocardial injury in trauma; and the significance of increased serum troponin in an acute stroke and other non-cardiac diseases. Contributed by experts in the field, this broad collection provides a unique reference for healthcare workers, medical students and research investigators who have an interest in troponin-based laboratory tests. Readers will not only acquire and in depth state-of-the-science understanding of troponin structure and diagnostic applications, but they will also be exposed to visions leading into future developments toward advancing troponin detection and improving clinical applications.

Read more less

Book SynopsisIn this book, the physiotherapist, sleep specialist or general health-care provider finds a detailed review about what can be done to handle Restless Legs Syndrome and Periodic Leg Movements in terms of scientifically proven exercise and physical interventions in physiotherapy daily practice. For those new to the field, there''s a basic overview of sleep and it''s disorders, followed by chapters about the Restless Legs Syndrome and its companion disorder, the Periodic Leg Movements. Special patients force us to reinvent and think again the ways we deal with disorders. In this book, the health-care provider will gain a fresh perspective to deal with Restless Legs Syndrome and Periodic Leg Movements in all patients alike.

Read more less

Book SynopsisBone mineral density (BMD) is a determinant of bone health. Phenotype, age, race, gender, activity level and overall health status all affect BMD. Recent research has shown that early pregnancy loss could be associated with bone mineral density. Reduced bone mass, bone density and consequently the pathological conditions, osteopenia and osteoporosis, represent significant health problems and contribute to disability, mortality, and reduced health related quality of life among older women and men. This book examines disorders that affect bone density, such as rickets and osteomalacia, and discusses screening and treatment options available for these and other bone disorders.

Read more less

Book SynopsisPhysiological functions of the body (muscle contraction, visceral activities, glandular functions, etc.) are regulated autonomously by a constituent of the peripheral nervous system commonly known as the autonomic nervous system (ANS). The ANS is controlled by centers found in the spinal cord, brain stem and hypothalamus. The authors of this book discuss the clinical features, functions and disorders of the ANS.

Read more less