Pharmacology Books

Book SynopsisWas ist gemeint, wenn von „Hennaverecker“, „Nachtgunkeln“ oder der „nackten Jungfer“ die Rede ist? Der „Arends“ listet die volkstümlichen Bezeichnungen von Heilkräutern, Drogen, Arzneimitteln und Chemikalien und ihre wissenschaftliche Übersetzung auf, so dass sich schnell herausfinden lässt, was sich hinter dem jeweiligen Namen verbirgt. Das bewährte und umfassende Werk wurde gründlich überarbeitet und mit aktuellen phytotherapeutischen Werken abgeglichen. Auch der neuen Nomenklatur der Drogen wurde Rechnung getragen.Table of ContentsVorwort.- Lexikalischer Teil von A - Z.

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Book SynopsisKompaktes Wissen immer dabei: das Pflege mini Arzneimittel gibt professionell Pflegenden im Berufsalltag übersichtlich alle wichtigen Informationen zu häufig genutzten Arzneimitteln. Wirkung, Nebenwirkungen, Indikationen und Besonderheiten werden für unterschiedliche Arzneimittelgruppen erläutert, z.B. Schmerzmittel, Schlafmittel, Wirkstoffe bei Herzrhythmusstörungen oder Asthma, bei Obstipation oder Diabetes, Diuretika und Antibiotika.Abgestimmt auf das, was Pflegende in der Praxis wissen müssen. Kompakt für die Kitteltasche zum Nachlesen. Für Pflegefachkräfte und andere Gesundheitsberufe, denen Sicherheit im Umgang mit Medikamenten oberstes Gebot ist.Table of ContentsGrundlagen der Arzneimittellehre.- Arzneimittel u.a Schlafmittel, Schmerzmittel, Arzneimittel bei Migräne, Psychopharmaka, Antibiotika, Antiemetika, Antiepileptika, Antiparkinsonmittel.- auf das Herz-und Gefäßsystem wirkende Stoffe.- Arzneimittel bei Bluthochdruck, zur Blutgerinnung.- Arzneimittel bei Husten, Asthma und Lungenerkrankungen.- Diuretika, Arzneimittel gegen Obstipation und Durchfallerkrankungen.- Arzneimittel gegen Bakterien und Pilze.- Medikamente gegen Diabetes.- Arzneimittelgesetz, Betäubungsmittelgesetz.- Medikamentenübersicht und Glossar.

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Book SynopsisAuch in der 3., vollständig aktualisierten und erweiterten Auflage gibt das bewährte Buch eine systematische und praxisnahe Einführung in die Anwendung von Heilpflanzen in der Veterinärpraxis. Nach Indikationsgebieten geordnet werden zu jeder relevanten Pflanze die botanischen Eigenschaften, die Inhaltsstoffe und ihre Wirkungen, die Anwendungsgebiete mit exakten Dosierungen und Rezepturen und mögliche unerwünschte Wirkungen sowie rechtliche Regelungen zur Anwendung beschrieben; zusätzlich werden alle Pflanzen durch eine oder mehrere Abbildungen veranschaulicht. Neu in der 3. Auflage sind die Beschreibungen 8 weiterer Pflanzen, die Angabe der verfügbaren Pflanzenpräparate zu jeder Heilpflanze, Hinweise auf spezifische Regelungen zur Anwendung in der Schweiz sowie eine Liste ausgewählter Bezugsquellen im deutschsprachigen Raum. Eine neu eingeführte übersichtliche Tabelle erleichtert für die wichtigen Anwendungsgebiete die Suche nach den geeigneten Heilpflanzen. Einführende Kapitel zu den pharmakologischen und rechtlichen Grundlagen sowie ein ausführlicher Anhang mit Begriffserklärungen und Listen zum Nachschlagen runden die Darstellung ab.Table of ContentsVorwort zur 3. Auflage.- Vorwort zur 1. Auflage.- Inhaltsverzeichnis .- Autorenverzeichnis.- Teil I Bedeutung der Heilpflanzen in der Veterinärmedizin: Der Umgang mit dem kranken Tier.- Geschichte und heutige Bedeutung der Heilpflanzen in der Veterinärmedizin.- Beachtung von tierartspezifischen Besonderheiten in der Anwendung von Heilpflanzen.- Rechtliche Voraussetzungen für die Anwendung von Heilpflanzen.- Pflanzliche Zubereitungen.- Sekundäre Pflanzeninhaltsstoffe – Phytochemische und phytopharmakologische Grundlagen.- Vergiftungen mit Pflanzen.-Teil II Heilpflanzen und ihre Anwendungsgebiete: Gastrointestinale Erkrankungen I: Appetitlosigkeit, Verdauungsbeschwerden, Blähungen, Entzündungen der Magen-Darm-Schleimhaut.- Gastrointestinale Erkrankungen II: Durchfallerkrankungen (Diarrhoe).- Gastrointestinale Erkrankungen III: Verstopfungen (Obstipation).- Erkrankungen der Galle, Gallenwege und Leber.- Hauterkrankungen I: Verletzungen (Prellungen, Verstauchungen, Quetschungen), schlecht heilende Wunden und Geschwüre.- Hauterkrankungen II: Lokale entzündliche Erkrankungen der Haut und Schleimhaut.- Herzbeschwerden und Herzinsuffizienz.- Erkrankungen des oberen und unteren Respirationstraktes.- Nieren- und Blasenerkrankungen, entzündliche Erkrankungen der ableitenden Harnwege.- Angst- und Unruhezustände, Reizbarkeit, nervös bedingte Magen-Darm-Störungen.- Zerebrale und periphere Durchblutungsstörungen, Rheuma und Muskelschmerzen.- Stress- und Ermüdungszustände, Tumoren und Allergien.- Ektoparasiten.- Anhang: Verzeichnis der deutschen und wissenschaftlichen Pflanzennamen.- Rezepturanweisungen in deutscher und lateinischer Sprache.- Europäische Verordnung: VO (EU) 37/2010.- Abgrenzungsliste CH: Einstufung pflanzlicher Stoffe und Zubereitungen als Futtermittel oder Tierarzneimittel in der Schweiz.- Lila Liste – Remedia ad usum veterinarium.- Bezugsquellen für Arzneipflanzen und pflanzliche Produkte.- Wichtige Internetadressen.- Glossar botanischer BegriffeBildquellenverzeichnis.- Literatur.- Weiterführende Literatur.- Sachverzeichnis.

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Book SynopsisIm seit 1985 jährlich als Buch erscheinenden Arzneiverordnungs-Report werden die Rezepte für die Patienten der gesetzlichen Krankenversicherung (GKV) mit Methoden der evidenzbasierten Medizin analysiert.Seit dieser Zeit bietet der Report eine unabhängige Informationsmöglichkeit über die verschiedenen Komponenten der Arzneimittelverordnung und trägt damit zur Transparenz des Arzneimittelmarkts, zur Bewertung von Arzneimitteln und zu einer sowohl zweckmäßigen und sicheren evidenzbasierten als auch wirtschaftlichen Arzneitherapie bei.Table of ContentsArzneiverordnungen 2016 im Überblick.- Zulassungsverfahren für neue Arzneimittel in Europa.- Neue Arzneimittel 2016.- GKV-Arzneimittelmarkt 2016: Trends und Marktsegmente.- Ergebnisse des AMNOG-Erstattungsbetragsverfahrens.- Rabattverträge.- Europäischer Preisvergleich für patentgeschützte Arzneimittel.- Indikationsgruppen.- Arzneiverordnungen nach Arztgruppen.- Arzneiverordnungen nach Alter und Geschlecht.- Arzneiverordnungen nach Regionen.- Ergänzende statistische Übersicht.- Stichwortverzeichnis.

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Book Synopsis Dieses Buch fasst den aktuellen Forschungsstand zum Thema Cannabis zusammen. Hierfür wurden alle bedeutsamen, in den letzten 10 Jahren in deutscher und englischer Sprache publizierten Forschungsarbeiten systematisch recherchiert und ausgewertet. Dargestellt werden: - psychische, organische und soziale Risiken des Konsums pflanzlicher und synthetischer Cannabisprodukte zu Rauschzwecken, - Wirksamkeit, Verträglichkeit und Sicherheit von Cannabisarznei bei organischen und psychischen Erkrankungen, - Motive und Erwartungen eines nichtärztlich verordneten Gebrauchs von Cannabis im Sinne einer Selbstmedikation. Die Expertise liefert einen umfassenden Überblick über die aktuelle Literatur. Sie bewertet das therapeutische Potenzial und die Risiken von Cannabis entsprechend internationaler methodischer Vorgaben der evidenzbasierten Medizin. Die Expertise dient somit als solides Nachschlagewerk. Ihr Auftraggeber war das Bundesministerium für Gesundheit. Trade Review“... Dieses deutschsprachige Buch ist ein Muss für alle, die Argumente für die Cannabis-Diskussion benötigen, sowie für jene, denen es um wissenschaftliche Evidenz geht.” (grow!-Magazin, Heft 5, 2019)“... ist diese wissenschaftliche Bestandaufnahme eine Fundgrube rund um biochemische Aspekte, zu Freizeitgebrauch und Arznei. ... Mehr als 30 Autoren haben ein fundiertes Nachschlagewerk für alle medizinischen Berufsgruppen geschaffen.” (Health & Care Management, Heft 10, 2019)Table of Contents1 Cannabis, Cannabinoide und das Endocannabinoidsystem.- 2 Methode des systematischen Reviews.- 3 Cannabiskonsum zum Freizeitgebrauch.- 4 Befunde im Zusammenhang mit medizinisch verwendeten Cannabinoiden.- Stichwortverzeichnis.- Online Material

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Book SynopsisDer Arzneimittel-Kompass, der sowohl als Open-Access-Publikation als auch als gedrucktes Buch erscheint, widmet sich in seiner ersten Ausgabe dem Schwerpunktthema „Hochpreisige Arzneimittel – Herausforderung und Perspektiven“. Angesichts der hohen Preise für Arzneimittel analysieren namhafte Autorinnen und Autoren, wie eine faire Preisgestaltung gelingen kann. Einerseits gilt es, die Forschung und Entwicklung eines Arzneimittels adäquat zu honorieren, andererseits aber auch die Verfügbarkeit von bezahlbaren Medikamenten sicherzustellen.Der Arzneimittel-Kompass 2021 geht unter anderem den folgenden Fragen nach: Wie kann die gesellschaftliche Zahlungsbereitschaft für neue und hochpreisige Arzneimittel objektiver beurteilt werden? Welchen Zusammenhang gibt es zwischen dem Nutzen von Arzneimitteln für die Behandelten und den aufgerufenen Preisen, insbesondere bei den Krebstherapien? Wie können die renditemaximierende Wachstumsstrategie börsennotierter Pharmaunternehmen und eine bezahlbare Arzneimittelversorgung in Einklang gebracht werden? Welche Verfahren der Preisfindung kommen international zur Anwendung und welche möglichen neuen Modelle werden diskutiert? Wie werden die Herausforderungen und der Weiterentwicklungsbedarf der Preisfindung von den Marktakteuren wie gesetzlichen Krankenkassen, Ärztinnen und Ärzten oder pharmazeutischer Industrie bewertet? Zentrale Entwicklungen im Arzneimittelmarkt werden beschrieben und analysiertDie Ausgaben für Arzneimittel und Impfstoffe, die im Jahr 2020 mit 47,8 Mrd. € einen neuen Höchststand erreicht haben, werden differenziert in den Blick genommen. Die Auswertungen basieren auf 820 Millionen Verordnungen von mehr als 210.000 Ärztinnen und Ärzten für 73,4 Mio. GKV-Versicherte. Besondere Beachtung gilt den Trends in den Marktsegmenten Generika, Biosimilars, Patentarzneimittel und Orphan Drugs. Die Wirksamkeit der gesetzlichen Regulierungsinstrumente wird gleichfalls betrachtet.Trade Review“... Das Buch beschreibt, welche Herausforderungen mit Hochpreisarzneimitteln verbunden sind und zeigt Optionen für den zukünftigen Umgang mit diesen auf ...” (gelbe-liste.de, 9. November 2021)Table of ContentsVorwort/Editorial der Herausgebenden.- I. Zum Einstieg: Gesellschaftliche/Volkswirtschaftliche Sicht auf Arzneimittelpreise.- Gesellschaftliche/Volkswirtschaftliche Sicht auf (zukünftige) Finanzierbarkeit von Arzneimitteln.- Ansätze der Heterodoxen Ökonomik.- Ethische Sichtweise auf hochpreisige Arzneimittel.-II. Vertiefende Diskussion ausgewählter Fragestellungen: Entwicklung der Arzneimittelkosten in der ambulanten Versorgung.- Hochpreisigkeit bei Onkologika.- Die Bedeutung der Pharmaindustrie in Deutschland.- Beschleunigte Zulassung von Arzneimitteln: Herausforderungen für PatientInnen, Datenqualität und faire Preise.- Preisregulierungen im internationalen Vergleich.- Ansätze zur Begegnung der Hochpreisigkeit.- Ein transparentes Modell für faire Preise für innovative Arzneimittel in Europa.-III. Sicht der Marktbeteiligten: Sicht der gesetzlichen Krankenversicherung.- Hochpreisige Arzneimittel – Herausforderungen und Perspektiven aus Sicht der Vertragsärzteschaft.- Hochpreisige Arzneimittel: Mehr Perspektive als Herausforderung.- Internationale Sicht. Gut sind nur Medikamente, die auch verfügbar sind.-IV. Der GKV-Arzneimittelmarkt im Jahr 2020: Der Arzneimittelmarkt im Überblick.- AMNOG: Ziel, Funktionsweise und Ergebnisse.

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Book SynopsisDer Arzneimittel-Kompass 2022, der sowohl als Open-Access-Publikation als auch als gedrucktes Buch erscheint, widmet sich dem Schwerpunktthema „Qualität der Arzneimittelversorgung“. Dabei stehen die Qualitätssicherung und das Qualitätsmanagement in der zweiten Ausgabe des Arzneimittel-Kompass im Fokus. Namhafte Autorinnen und Autoren analysieren Stärken und Schwächen in der Arzneimittelversorgung und beschreiben die Umsetzungsherausforderungen, die der komplexe Prozess einer optimalen Versorgung der Bevölkerung mit Arzneimitteln mit sich bringt. Der Arzneimittel-Kompass 2022 geht unter anderem den folgenden Fragen nach: Was wird unter Qualität in der Arzneimittelversorgung verstanden? Wie ist die Qualität in der Arzneimittelversorgung spezifischer Gruppen von Patientinnen und Patienten wie beispielsweise von Kindern, älteren Menschen oder MS-Erkrankten zu bewerten? Sind Defizite bei der Verordnung von Kontrazeptiva, bei der Hormonersatztherapie, an der Schnittstelle von ambulanter und stationärer Versorgung oder von Patientinnen und Patienten mit Covid-19 erkennbar? Welche Hürden und Hindernisse gilt es zu bewältigen, um diese Defizite auszugleichen? Wie kann das Wissen über eine qualitativ hochwertige Arzneimittelversorgung auch in der Praxis umgesetzt werden? Zentrale Entwicklungen im Arzneimittelmarkt werden analysiert und beschriebenDie Ausgaben für Arzneimittel und Impfstoffe, die im Jahr 2021 mit 52,0 Mrd. € einen neuen Höchststand erreicht haben, werden differenziert in den Blick genommen. Die Auswertungen basieren auf 810 Millionen Verordnungen von mehr als 210.000 Ärztinnen und Ärzten für 73,3 Mio. GKV-Versicherte. Besondere Beachtung gilt den Trends in den Marktsegmenten Generika, Biosimilars, Patentarzneimittel und Orphan Drugs. Die Wirksamkeit der gesetzlichen Regulierungsinstrumente wird gleichfalls betrachtet. Ein Blick auf die Arzneimittelversorgung in Deutschland im Vergleich zu anderen europäischen Ländern rundet diesen Teil ab.Die Herausgeberinnen und HerausgeberDer Arzneimittel-Kompass 2022 wird von Helmut Schröder, Dr. Carsten Telschow und Dr. Melanie Schröder vom Wissenschaftlichen Institut der AOK (WIdO), Prof. Dr. med. Petra Thürmann von der Universität Witten-Herdecke und Prof. Dr. med. Reinhard Busse von der Technischen Universität Berlin herausgegeben.Table of ContentsI Zum Einstieg ins Thema: Einleitung und Zusammenfassung.- Qualität der Arzneimittelversorgung – Theoretischer und konzeptueller Rahmen.- II Vertiefende Diskussion ausgewählter Fragestellungen: Multimedikation.- Potenziell inadäquate Medikation für ältere Menschen – PRISCUS 2.0.- Arzneimittelversorgung in Pflegeheimen.- Arzneimittelversorgung von Kindern.- Menopausale Hormontherapie: Evidenz und Eingang in die Praxis .- Orale Kontrazeptiva: Wie neugewonnene Evidenz zu einer Veränderung der Arzneimitteltherapie führt.- Arzneimittelversorgung bei Multipler Sklerose.- Arzneimittelversorgung zwischen ambulanter und stationärer Behandlung.- Arzneimittelnutzung unter Pandemiebedingungen.- III Sicht der Akteurinnen und Akteure: Sicht der Vertretung der Patientinnen und Patienten – wichtige Faktoren der Qualität der Arzneimittelversorgung.- Sicht der Ärztinnen und Ärzte: Ungenügend sichere Prozesse durch Risiko-induzierende Rahmenbedingungen.- Sicht der Apothekerschaft: Gedanken zur Qualität der Arzneimittelversorgung in Deutschland.- Die Perspektive der Krankenhauspharmazie: Closed Loop Medication Management – Goldstandard im Krankenhaus.- Sicht der gesetzlichen Krankenversicherung - Entscheidende Aspekte der Arzneimittelversorgungsqualität: Passgenau, verlässlich, bezahlbar.- Sicht der pharmazeutischen Industrie - Arzneimittelversorgung in Deutschland: die richtigen Weichenstellungen für Innovationen.- IV Der Arzneimittelmarkt 2021: Der Arzneimittelmarkt 2021 im Überblick.- Ergebnisse des AMNOG-Erstattungsbetragsverfahrens.- Arzneimittelmarkt und -versorgung in Deutschland im europäischen Vergleich.- Die Autorinnen und Autoren.

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Book SynopsisDer Arzneiverordnungs-Report ist seit 1985 eine gemeinsame Publikation von Autoren aus Pharmakologie, Klinik, Praxis, Gesundheitsökonomie und Krankenversicherung. Basis sind die Verordnungsdaten von Arzneimitteln für ambulante Patienten der gesetzlichen Krankenversicherung (GKV). Table of ContentsI. Allgemeine Verordnungs- und Marktentwicklung.-1. Arzneiverordnungen 2021 im Überblick.-2. Neue Arzneimittel 2021.-3. Kosten-Nutzen-Analysen von Arzneimitteln.-4. Überblick über Maßnahmen zur Förderung des Einsatzes von Biosimilars in europäischen Ländern.-II. Maligne Erkrankungen.-5. Hämatologische Neoplasien und solide Tumore.-III. Herz-Kreislauf-Erkrankungen.-6. Arterielle Hypertonie.-7. Herzerkrankungen.-IV. Blut und Gerinnung.-8. Anämien.-9. Gerinnungsstörungen.-V. Erkrankungen des Stoffwechsels und des Gastrointestinaltraktes.-10. Diabetes.-11. Lipidstoffwechselstörungen.-12. Magen/Darm- und Lebererkrankungen.-13. Gicht.-14. Osteoporose und Calcium- und Phosphatregulation.-15. Vitamine und Mineralstoffpräparate.-IV. Infektionserkrankungen.-16. Bakterielle und virale Infektionserkrankungen und Mykosen.-VII. Schmerz, Entzündung und Immunsystem.-17. Symptomatische Behandlung von Schmerz, Fieber und Entzündung.-18. Migräne.-19. Krankheitsmodifizierende Arzneistoffe für Autoimmunerkrankungen.-20. Glukokortikoide.-21. Immunglobuline und Immunsuppressiva.-VIII. Erkrankungen des Nervensystems und der Augen.-22. Depression, Angststörungen, bipolare Störung, Schizophrenie, Aufmerksamkeitsdefizithyperaktivitätssyndrom.-23. Multiple Sklerose.-24. Epilepsien.-25. Morbus Parkinson.-26. Schlafstörungen.-27. Schwindel und Erbrechen.-28. Neurodegenerative Erkrankungen.-29. Augenerkrankungen.-IX. Erkrankungen der Lungen und der Luftwege.-30. Husten und Auswurf.-31. Chronisch-obstruktive Lungenerkrankung und Asthma.-32. Hals-, Nasen- und Ohrenerkrankungen.-X. Urologische Erkrankungen.-33. Nieren-, Harnwegs- und Prostataerkrankungen.-34. Diuretika.-XI. Hauterkrankungen und Allergien.-35. Hauterkrankungen.-36. Allergien.-XIII. Hormonsystem.-37. Schilddrüsenerkrankungen.- 38. Sexualhormone.-39. Hypophysen- und Hypothalamushormone.-XIII. Erkrankungen des Mundes und der Zähne.-40. Oral- und Dentalerkrankungen .

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Book SynopsisI. Allgemeine Grundlagen.- II. Mediatoren/Transmitter.- III. Pharmaka mit Wirkung auf das Immunsystem und zur Behandlung entzündlicher Erkrankungen.- IV. Pharmaka mit Wirkung auf das Nervensystem.- V. Pharmaka mit Wirkung auf das Herz-Kreislauf-System.- VI. Pharmaka mit Wirkung auf das respiratorische System.- VII. Pharmaka mit Wirkung auf Magen-Darm-Trakt.- VIII. Pharmaka mit Wirkung auf hormonelle und metabolische Systeme.- IX. Dermatika.- X. Antiinfektiva.- XI. Antineoplastika.- XII. Toxikologie.

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Book SynopsisThe present work has been assembled with the aim of providing a comprehensive and inclusive resource on medicinally and commercially significant plants, focusing on biosystematics, reproductive biology, genetic improvement, cultivation, conservation, chemistry, pharmacology, trade, value addition, and future prospects. This book is intended for a broad readership. The ten plants that are featured in this book are: Aegle marmelos, Aloe vera, Saussurea costus, Aconitum heterophyllum, Asparagus racemosus, Berberis aristata, Bergenia ciliata, Crocus sativus, Picrorhiza kurroa, and Piper longum.

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Book SynopsisIn the current climate of quality assurance, it is essential for every organization to ensure that it meets its quality objectives. The book under consideration has been prepared with this goal in mind, focusing on the fundamental techniques, methods, plans, and certification procedures for quality assurance, while taking into account the syllabus for quality assurance techniques outlined by various Indian universities. The aim of this publication is to provide both basic and updated information on a range of quality assurance data to students pursuing a professional program in pharmacy. The book specifically covers statistical methods utilized in method development, with a focus on modern techniques like SUPAC and PAT, as well as providing a comprehensive explanation of ISO, GMP, and ICH guidelines.

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Book SynopsisThe book titled Plant Secondary Metabolites is structured into 11 chapters, each with broader headings that encompass an introduction, history, biosynthesis, essential oils/terpenes/terpenoids, alkaloids, glycosides, gums & mucilages oleoresins, plant amines, techniques, and biotechnological approaches. To make the information more accessible and useful for undergraduate and postgraduate students in agriculture, ayurveda, pharmacy, naturopathy, and home sciences, the book includes 45 tables, 60 figures, chemical equations, and color photographs. The aim of the book is to provide a comprehensive and concise source of information for students, researchers, and faculty members in related fields. The book is intended to serve as a valuable resource for individuals seeking to enrich their knowledge of plant secondary metabolites.

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Book SynopsisThe book entitled "Plant Secondary Metabolites" is divided in 11 chapters with broader headings which include introduction, History, Biosynthesis, Essential Oils/Terpenes/Terpenoids, Alkaloids, Glycosides, Gums & Mucilages Oleoresins, Plant amines, Techniques and Biotechnological approaches. 45 tables, 60 figures, chemical equations and colour photographs have been used to make the information useful for under-graduate and post-graduate students of agriculture, ayurveda, pharmacy, naturopathy and home sciences to enrich their knowledge is not only scare but is also scattered and hence an attempt has been made here to provide the best available information to students, researchers and faculties in resembling disciplines under one roof.Table of Contents1. Introduction. 2. History of Secondary Metabolites. 3. General Biosynthetic Pathways. 4. Essential Oils/Terpenes/Terpenoids. 5. Alkaloids. 6. Glycosides and Plant Pigments. 7. Gums and Mucilages. 8. Oleoresins. 9. Plant Amines and Poisonous Plants. 10. Assay of Secondary Metabolites. 11. Biotechnological Approaches and Applications of Plant Secondary Metabolites

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Book SynopsisIt gives me immense pleasure to present a book entitled "Quality assurance techniques in pharmaceuticals". Need to write this book is ever increasing the data on the subject matter of quality assurance. In the era of quality assurance, every firm need to be quality assured so that it can achieve its quality goal. Book is prepared to emphasis on the basic techniques, methods, plans, certification procedures for quality assurance, keeping in mind the syllabus of quality assurance techniques laid by various Indian universities. Goal of this book is to provide primary and update knowledge of various quality assurance data to master of pharmacy students in the professional programme of their study. The on statistical methods used for method development is prepared by keeping in mind the need of method development for various drug combinations. Special emphasis is given on modern techniques like SUPAC and PAT. Beside these ISO,GMP,ICH Guidelines are very well explained.Table of Contents01. Basic Terminology Used In Quality Assurance 02. Total Quality Management 03. ISO 9001 : 2000 04. Environmental Management Systems and ISO 14000 05. GMP and GMP Compliance 06. Master Formula Record 07. Good Documentation Practices 08. Validation 09. Statistical Methods Used For Method Development 10. Analytical Method Development for Pharmaceutical Formulations 11. Guidelines on Audit Quality 12. ICH Harmonised Tripartite Guideline for Pharmaceutical Quality System

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Book SynopsisGallery of Medicinal Plants (Dravyaguna Vigyan) is an excellent book in its field Ayurvedic Materia Medica which covers all medicinal plants and drugs of animal-origin included in Paper-II of Dravyaguna Vigyan, as per the Central Council of Indian Medicine (CCIM) syllabus. Not only is this book a monograph, but it also serves as a color atlas of medicinal plants. It will be an immensely valuable resource for the students, faculty, academicians, and researchers in Ayurveda, homeopathy, Unani, Siddha, botany, pharmacy, medicinal plants, and other related branches of study at both undergraduate and postgraduate levels. Key Features: Emphasis is laid on the identification of different plants, as the book contains 1000+ colored images of parts of an individual plant The chapters discuss histological, mythological, and spiritual data along with the controversial aspects of medicinal plants Key characters for identification, rasapanchak (Ayurvedic properties), points to ponder, etc. are placed in colored boxes for easy remembrance Folklore and ethnopharmacological uses, own experience, and recent research data are given in addition to classical information Frequently asked questions are also appended at the end of the book Table of ContentsPart I: Detailed Plants Part II: Nondetailed Plants Part III: Jangama Dravya (Drugs of Animal Origin) Part IV: Ahara Dravya

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book SynopsisThis book presents the scientific evidence for the role of vitamin C in health and disease and offers new guidance on vitamin C intake in humans. The importance of vitamin C in preventing cancer and cardiovascular disease, its relevance to aging and stress, and its impacts on each of the human body systems are thoroughly assessed on the basis of the author’s extensive research and his deep understanding, as an anatomy professor, of the body as a whole. Findings published in the international scientific literature are fully taken into account, and due consideration is also given to empirical evidence, bearing in mind that mechanisms of action cannot always be precisely defined in the absence of human experiments. Beyond providing an up-to-date scientific perspective on the effects of vitamin C, the author hopes to promote human health worldwide by encouraging proper use of the vitamin. To this end, recommendations are made on the amount of vitamin C that should be taken daily and on the best way to take it. The book will be of interest to researchers, clinicians, and all others who wish to learn more about this vitamin and its significance. Table of ContentsPreface.- Chapter I. Introduction.- 1.History of Discovery of Vitamin C.- 2.What is vitamin C?.- 3.Chemical Properties of Vitamin C as Anti-oxidant.- 4.Biological Activities as Co-factors.- 5.Scientific Background of Optimal Dose.- 6.How to take?.- 7.Adverse Effects.- Chapter II. Cardiovascular System.- Chapter III. Cancer.- Chapter IV. Immune system.- Chapter V. Respiratory System, Common Cold and Influenza.- Chapter VI. Central Nervous System.- Chapter VII. Aging.- Chapter VIII. Stress.- Chapter IX. Gastrointestinal (GI) System.- Chapter X. Liver.- Chapter XI. Skin.- Chapter XII. Eye.- Chapter XIII. Summary and Conclusion.

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Book SynopsisBarbados has a strong base in the practice of folklore botanical medicines. Consistent with the rest of the Caribbean region, the practice is criticized due to the lack of efficacy and safety testing of the plants. This book identifies common medicinal plants used historically and currently in Barbados for the treatment of common communicable and non-communicable diseases. It starts by describing the historical to current context of communicable and non-communicable diseases in Barbados. It also outlines the historical and current context of the use of medicinal plants including factors influencing their use by Barbadians.The medicinal plants in the book were reviewed previously and grouped on their practice to treat communicable and non-communicable diseases and also botanical classification. The identified phytochemicals from the plants were compared to established drug compounds approved for the conventional treatment of illnesses and also established phytochemicals. The book outlines that sixty six percent (66%) of medicinal plants entries identified for the treatment of communicable and non-communicable diseases contain pharmacologically active phytochemicals; while fifty one percent (51%) of the entries contain phytochemicals with activities consistent with their reported use. These findings conclude that folklore botanical medicine is well grounded scientifically.The primary readers of this book are Barbadians and other Caribbean nationals who practice the use of herbal remedies and are keen on validating their uses. The secondary audiences are academics who wish to investigate these herbal remedies as sources of new drug compounds and clinicians who wish to be guided about possible drug – herb interactions. The book presents insightful information to both groups about the possible uses of herbal remedies. This book is by no means advocating the irrational use of any medication.

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Book SynopsisThis volume describes methods and protocols for the fragment-based screening of proteins using Surface Plasmon Resonance (SPR). The initial chapter of the book discusses the principle of SPR for the identification of biomolecular interactions, while the subsequent chapters introduce methods for labelling proteins with different tags including, histidine and biotin tags. It also discusses techniques and factors that affect the amine and biotin-streptavidin coupling and methods to optimize the interactions. Next, it describes fragment preparation for screening in SPR and presents methods to calculate equilibrium dissociation constant (KD) and ligand efficiency (LE). It reviews techniques of next-generation injections that improve the efficiency of the characterization process over traditional SPR by determining the kinetics and affinity in a single step. Finally, the book elucidates a comprehensive yet representative description of challenges associated with the molecular interaction of proteins using SPR.Table of ContentsChapter 1_Introduction to SPR.- Chapter 2_ Principle of SPR (OneStep).- Chapter 3_Identification of Fragment library.- Chapter 4_Preparation of protein with Histidine Tag.- Chapter 5_Preparation of protein with Biotin Tag.- Chapter 6_Protein stability using Thermal Shift Assay (TSA) - pH.- Chapter 7_Protein stability using Thermal Shift Assay (TSA) – DMSO.- Chapter 8_Preparation of Sensor.- Chapter 9_ Optimization and validation of Amine coupling.- Chapter 10_ Optimization and validation of Biotin-strepavidin coupling.- Chapter 11_ Preparation of Fragment for Screening in SPR.- Chapter 12_ Screening of Fragment in SPR.- Chapter 13_ Analysis of Data.- Chapter 14_ Identification and arraying of HITS.- Chapter 15_ Confirmation of Hits – Kinetics (kon, koff, KD, LE).

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Book SynopsisThis book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.Table of Contents1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa.- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds.- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects.- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant.- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana.- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions.- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities.- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production.- 9 Saffron: A prized herb with therapeutic potential against diabetes.- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors.- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future.- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants.- 13 Production of anti-diabetic lignans in flax cell cultures.- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect.- 15 Cryopreservation of Anti-diabetic plants.

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Book SynopsisThis book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.Table of Contents1. Preface2. Introduction2.1. Nanotechnology and its influence2.2. Novel drug delivery systems2.3. Significance of nanomaterials in respiratory diseases3. Nanoparticles in chronic respiratory diseases3.1. Inflammatory respiratory diseases (Asthma, Chronic obstructive pulmonary disease, Tuberculosis, Lung cancer, Cystic fibrosis)3.2. Formulation and role of microparticles, microspheres, microemulsions in respiratory diseases3.3. Formulation and role of polymeric and inorganic nanoparticles3.4. Liposomes, niosomes, and dendrimers targeting in respiratory diseases3.5. Micelle targeting in respiratory diseases4. Targeting immune-system/ cellular level (macrophages & neutrophils) in respiratory diseases using advanced drug delivery systems5. Mucoadhesive drug delivery system in respiratory diseases6. Advancement in translational respiratory research using nanotechnology7. Nanotechnology in pulmonary disease diagnosis8. Clinical trials using in vitro and in vivo models9. Targeting biofilms in respiratory diseases using novel drug delivery systems10. Future prospects and challenges11. Bibliography12. Glossary

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Book SynopsisThis book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life.Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of ContentsChapter 1: GENCODE Annotation for the Human and Mouse Genome: A User Perspective.- Chapter 2: Genecard a database for gene annotation.- Chapter 3: IHEC: International human epigenome portal.- Chapter 4: Atlas of miRNAs and their Promoters in Human and Mouse.- Chapter 5: RefEX- Reference Expression Dataset.- Chapter 6: The mouse Gene Expression Database.- Chapter 7: ChIP-Atlas.- Chapter 8: Protein structural changes based on structural comparison.- Chapter 9: Single Cell Databases: an Emerging and Essential Tool.- Chapter 10: scIVA: Single Cell Interactive Visualisation and Analysis Data Mining Platform.- Chapter 11: Access and visualise high quality gene expression data with Stemformatics.- Chapter 12: Introduction to Practical Guide to Life Science Databases.

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Book SynopsisThis book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.Table of ContentsSection 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis. Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment). Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains. Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes. Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level. Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes. Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites. Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes. Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes. Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes. Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes. Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research. Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites. Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters. Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production Chapter 18: Synthetic biology in Actinomycetes for natural product discovery Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.

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Book SynopsisThis volume focuses on the potential use of probiotics in treating metabolic disorders such as diabetes mellitus, metabolic acidosis, and gut dysbiosis. Chapters draw an association between gut microbiota and its diversity with metabolic diseases like diabetes, obesity, related liver and gut disorders; gut-brain axis; increased inflammation, and a compromised immune system resulting from these manifestations and scope of intervention with probiotics. Special attention is laid on describing the mechanisms of action of such beneficial effects of probiotic administration. The ability of probiotics to decrease metabolic endotoxemia by restoring the disrupted intestinal mucosal barrier is also included.The volume is a comprehensive compilation describing the scope and application of probiotic and prebiotic therapy in treating metabolic disorders. Readers will discover how probiotics are not just confined to the microbiology industry but are showing promising results in the medical and pharmaceutical sectors.Table of Contents

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Book Synopsis​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.Table of ContentsChapter 1_Repurposing of drugs: Introduction to technologies and application. - Chapter 2_The value added medicine: Pharmacovigilance re-evaluated. - Chapter 3_Polypharmacology and drug repurposing. -Chapter 4_Comparative transcriptome analysis for infectious diseases towards the identification of cellular pathways for drug repositioning. -Chapter 5_Repurposing of drugs for the treatment of microbial diseases. -Chapter 6_RNA-dependent RNA polymerase (RdRp) - a potential therapeutic approach for Coronavirus drug repositioning. -Chapter 7_Drug repurposing for emerging and re-emerging infectious diseases. -Chapter 8_Drug repurposing for the control of COVID-19.-Chapter 9_Repurposing of anti-inflammatory agents in the potential treatment of SARS 2CoV -2 infection. -Chapter 10_Repurposing of immune-modulators for the treatment of cancer with a QSAR approach. -Chapter 11_ Repurposing Cancer drugs towards antiviral targets in developing countries. -Chapter 12_Repurposed drugs for hematological malignancies. -Chapter 13_Reverse translational approach in repurposing of drugs for anticancer therapy. -Chapter 14_Repurposing of Minocycline: a tetracycline antibiotic for neurodegenerative disorders. -Chapter 15_Drug repurposing for Neglected diseases: Approaches, challenges and promising candidates. ​

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Book SynopsisThis book provides a comprehensive overview of medicinal plants and their interaction with abiotic stress in terms of morphological, physiological, biochemical, and molecular variations, and explains the adaptation and tolerance mechanisms involved. It presents various mechanisms that become operative in medicinal plants to combat stressful situations. The book discusses the secondary metabolites and/or bioactive compounds produced in medicinal plants under abiotic stress conditions, and the use of biostimulants and/or phytoprotectants to alleviate the adverse effects of abiotic stresses on medicinal plants. Additionally, it is likely to address opportunities and challenges in molecular and omics studies of medicinal plants under abiotic stress conditions. Overall, the chapters are developed by eminent subject experts with due care and clarity and cover an up-to-date literature review with relevant illustrations. The book would cater to the need of graduate and post-graduate students, researchers as well as scientists, and may attract the attention of pharmaceutical companies/industrialists and health policymakers.Table of ContentsChapter 1. Medicinal plants and abiotic stress: An overview.- Chapter 2. Medicinal plants proteomics in response to abiotic stresses.- Chapter 3. Medicinal plants metabolomics in response to abiotic stresses.- Chapter 4. Secondary metabolite production in medicinal plants under abiotic stress.- Chapter 5. Effect of temperature (cold and hot) stress on medicinal plants.- Chapter 6. Effect of water stress (drought and waterlogging) on medicinal plants.- Chapter 7. Effects of gaseous pollutants on medicinal plants.- Chapter 8. Impact of salinity stress on medicinal plants.- Chapter 9. Impact of aridity on specialized metabolism: Concentration of natural products in plants.- Chapter 10.The role of PGPRs in medicinal plants under abiotic stress.- Chapter 11. Effect of mineral nutrition and PGRs on biosynthesis and distribution of secondary plant metabolites under abiotic stress.- Chapter 12. Impact of phytoprotectants on growth and yield of medicinal plants under abiotic stress.- Chapter 13. Biostimulants and phytohormones improve productivity and quality of medicinal plants under abiotic stress.- Chapter 14. Light (high light/UV radiation) modulates adaptation mechanisms and secondary metabolite production in medicinal plants.- Chapter 15. Recent Strategies to engineer alkaloid biosynthesis in medicinal plants.- Chapter 16. Genome-editing strategies for enhanced stress tolerance in medicinal plants.- Chapter 16. Phytoremediation potential of medicinal plants.- Chapter 17. Phytoremediation potential of medicinal plants.

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Book SynopsisThis book presents the major therapeutic applications of modified rice bran arabinoxylan compound (RBAC) in cancer as well as other chronic inflammatory diseases. Written by active researchers and clinicians in the field of RBAC, the chapters cover the basic science that defines the unique function of RBAC as well as the clinical evidence derived through human studies. Particular focus is on recent findings from research over the past decades. This book is both practical and evidence based. It will be a core resource for researchers, students, and practitioners of nutrition and natural medicine, as well as be of value to all healthcare professionals with interest in integrative medicine. Table of ContentsAttached

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Book SynopsisThis book presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology. The book offers a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, and the pharmaceutical sciences. The main purpose of the present book is to draw on the rich culture, folklore, and biodiversity of immunity-boosting medicinal plants of the Western Himalayas, with particular emphasis on the Indian Trans-Himalayan and Western Himalayan region. All the plants included in the present book are extensively used by the local tribes and people for their health-promoting properties from ancient times. This book will be a substantial contribution to the knowledge of the region and the country. Also, the book will be very useful to scientists, graduates, and undergraduates, along with researchers in the fields of natural products, herbal medicines, ethnobotany, pharmacology, chemistry, and biology. Further, it is an equally significant resource for a person working in different traditional medicinal systems; doctors (especially those engaged in Ayurveda, Chinese traditional medicinal system, Amchi, and allopathy); the pharmaceutical industry (for drug design and synthesis); biochemistry and biotechnology sciences; and the agricultural sciences. Table of Contents1. Introduction to Western Himalayas.- 2. Achillea millefolium L., Common Yarrow.- 3. Arisaema jacquemontii Blume, Jacquemont's Cobra Lily.- 4. Species of Arnebia genus found in the western Himalayas.- 5. Species of the Berberis genus found in the western Himalayas.- 6. Dactylorhiza hatagirea (D.Don) Soo – Himalayan Marsh Orchid.- 7. Fritillaria roylei Hook.f.: Himalayan Fritillary.- 8. Gentiana kurroo Royle: Himalayan Gentian.- 9. Habenaria intermedia D.Don and Habenaria edgeworthii Hook., f. ex Collett.: The Western Himalayan medicinal Plants.- 10. Humulus lupulus L.: Beer plant.- 11. Inula racemosa Hook. f. – Puskarmool: Its ethnobotanical uses, phytochemicals and pharmacological activities.- 12. Juniperus recurva Buch.-Ham. ex D.Don and Juniperus squamata D. Don: Himalayan Juniper.- 13. Lancea tibetica Hook.f. & Thomson: Ethnobotany, phytochemistry and pharmacology.- 14. Malaxis muscifera (Lindley) O. Kuntze. and Malaxis acuminata D. Don.: Jeevak.- 15. Picrorhiza kurroa Royle ex Benth.: Kutki.- 16. Species of the genus Polygonatum found in the Western Himalayas.- 17. Species of the genus Rhodiola found in the Western Himalayas.- 18. Saussurea lappa C.B. Clarke: Kushta/Kut.- 19. Saussurea lappa C.B. Clarke: Kushta/Kut.- 20. Species of the genus Selinum found in the western Himalayas.- 21. Swertia chirayita (Roxb. ex Flem.): Chirayata/Chiretta.- 22. Taxus wallichiana Zucc.: The Himalayan yew.- 23. Tribulus terrestris L.: Gokshur /Gokharu.- 24. Species the Genus Viola found in Western Himalayas.

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Book SynopsisChapter 1. Computational simulation of drug delivery at the molecular level.- Chapter 2. Computational modelling for formulation design.- Chapter 3. Computational fluid dynamics-the revolutionary innovative methodology in pharmaceutical industry.- Chapter 4. Population Modelling.- Chapter 5. Design of Experiments: Understanding optimization.- Chapter 6. Computational modelling of pharmaceutical die filling processes.- Chapter 7. Inhalation Aerosol based Targeted Drug Delivery to upper airways: Computational fluid dynamics (CFD) Approach.- Chapter 8. Pharmaceutical inhalation compounds development by using in silico modelling tools.- Chapter 9. Computational tools employed in Cheminformatics.- Chapter 10. Computational simulations as preformulation perspective for the delivery of Drugs.- Chapter 11. Computational Tools for Solubility prediction.- Chapter 12. Advances in the Computational Prediction of Absorption of Pharmaceuticals.- Chapter 13. Protein Binding Prediction by Computational Methods.- Chapter 14. Physiologically based Pharmacokinetic (PBPK) Modelling and Pharmacokinetic Pharmacodynamic (PKPD) Modelling.- Chapter 15. Prediction of Bio-permeability of Pharmaceuticals with advanced dynamic simulation studies.- Chapter 16. Accomplishment of Toxicity Prediction by CADD Tools.- Chapter 17. Metabolism Prediction: Identification of potential sites of metabolism in Lead molecules.- Chapter 18. Computer Assisted Simulation Studies for Identifying the Drug-Polymer Interactions.- Chapter 19. Recent Advances in Drug likeness screening by using the Software and Online tools.- Chapter 20. Mechanistic Understanding of the Anti-Alzheimer’s Agents with Computational Studies.- Chapter 21. Advances in the design of novel antidiabetic agents by using in silico approaches.- Chapter 22. Towards the mechanistic understanding of Atherosclerosis Drug Design.- Chapter 23. Modern computational intelligence based drug repurposing for Cancer Therapeutics.- Chapter 24. Computational analyses of mechanism of action of Antiepileptic Agents.- Chapter 25. Rational Approaches and Designing Strategies for Antihypertensive Agents.- Chapter 26. Drug discovery and computational strategies in the Multi-Drug Resistant Tuberculosis.- Chapter 27. The Network Pharmacology Approach to Uncover the Pharmacological Mechanism of Natural Products.

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Book SynopsisChapter 1_ Introduction to Exosome and its role in Brain disorders.- Chapter 2_ Exosomes: Biogenesis, Composition and Synthesis.- Chapter 3_ Therapeutic Impact of Exosomes in Stroke and Transient Ischemic Attack (TIA).- Chapter 4_ Role of exosomes in Multiple Sclerosis.- Chapter 5_ Therapeutic impact of exosomes Stroke and Transient Ischemic Attack (TIA).- Chapter 6_ Role of exosomes in Parkinson's and Alzheimer's diseases.- Chapter 7_ Role of exosomes in Epilepsy and other Seizure Disorders.- Chapter 8_ Role of exosomes in management of depression.- Chapter 9_ Role of Microbiota-Derived Exosomes in Gut-Brain Communication for the treatment of brain disorders.- Chapter 10_ Advancement of Engineered Exosomes to deliver therapeutic protein cargos in brain disorders.- Chapter 11_ Correlation between exosomes and neuro inflammation in various brain disorders.- Chapter 12_ Recent challenges of exosomes as novel carrier in various brain disorders.- Chapter 13_Advancement of radiolabeled exosomes in brain disorders.- Chapter 14_ Exosomes as future diagnostic tool for brain disorders.- Chapter 15_ Toxicity studies of exosomes and the potential overcome approaches.

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Book SynopsisMexican-American writer Fontes tells a startling tale of the clashes between men and women, rich and poor, Mexican and American in this dark story of life just south of the Texas border.Trade Review"Through the eyes of [the] small heroine, a wicked but touchingly vulnerable little girl . . . First Confession enjoys a robust plot and multidimensional characters. . . . Fontes's greatest talent, though, is her ability to see and define the world through the senses of a child." -- Philadelphia Inquirer"Simmering first novel. . . . Writing with a vivid sense of character, class, culture, and place, Fontes has produced a novel as nasty, compelling and horrendous as childhood itself." -- San Francisco Chronicle"Montserrat Fontes has listened to the rhythms that connect two languages, and divined a voice like nothing I've read before: Carson McCullers with a Spanish accent. First Confession invited me into the rich, dark place where life reveals itself to wide-eyed children, and it kept talking to me for a long time after I'd turned the final page." -- Barbara Kingsolver"A splendid tour de force. I picked the book up and could not put it down. . . . She renders the border-life in all its stark and realistic darkness. . . . The children, Andrea and Victor, are alive and full of light, carrying in their hearts a bit of each of us." -- Jimmy Santiago Boca

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Table of ContentsPreface Laura N. Vandenberg and Judith L. Turgeon 1. Endocrine disruptor global policy Christopher D. Kassotis and Leonardo Trasande 2. Toxicity testing and endocrine disrupting chemicals Laura N. Vandenberg 3. Epigenetics, estrogenic endocrine-disrupting chemicals (EDCs), and the brain Madeline Streifer and Andrea C. Gore 4. Endocrine disrupting chemicals (EDCs) and the neuroendocrine system: Beyond estrogen, androgen, and thyroid Heather B. Patisaul 5. Endocrine disrupting chemicals and reproductive disorders in women, men, and animal models Mary Jo Laws, Alison M. Neff, Emily Brehm, Genoa R. Warner and Jodi A. Flaws 6. Endocrine disrupting chemicals (EDCs) and sex steroid receptors Julianne M. Hall and Kenneth S. Korach 7. Endocrine disrupting chemicals and the mammary gland Laura N. Vandenberg 8. Impact of gestational exposure to endocrine disrupting chemicals on pregnancy and birth outcomes Vasantha Padmanabhan, Jacob Moeller and Muraly Puttabyatappa 9. Endocrine disrupting chemicals (EDCs) and placental function: Impact on fetal brain development William P. Marinello and Heather B. Patisaul 10. Endocrine disrupting chemicals and thyroid hormone action R. Thomas Zoeller 11. Inappropriately sweet: Environmental endocrine-disrupting chemicals and the diabetes pandemic Margaret C. Schulz and Robert M. Sargis 12. The new kids on the block: Emerging obesogens Raquel Chamorro-Garcia and Almudena Veiga-Lopez 13. Endocrine disrupting chemicals and breast cancer cells Philippa D. Darbre 14. EDCs and male urogenital cancers M.S. Bornman and N.H. Aneck-Hahn

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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