Pathology Books

Book SynopsisPart of the highly regarded Biopsy Interpretation Series, this fully revised volume provides practical, highly illustrated information on the diagnosis and prognosis of the full range of biopsies of the various tissues of the head and neck region, including the ear. Biopsy Interpretation of the Head and Neck, 3rd Edition, addresses both common and unusual issues that arise in day-to-day practice, with an emphasis on the complex area of the upper aerodigestive tract and ear. Discusses both neoplastic and non-neoplastic entities to help you arrive at an accurate diagnosis and guide patient management. Provides new information about emerging diagnostic entities and ancillary testing. Covers squamous cell carcinomas, HPV-related tumors, bony lesions, odontogenic lesions, and more. Incorporates selected and targeted use of ancillary techniques. Features 200 additional images online, as well as a 50-question test bank for self-assessment and review. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Read more less

Book Synopsis Selected as a Doody's Core Title for 2022!Extensively revised to bring you up to date with new pathologic entities, new treatment methods, and much more, Biopsy Interpretation of the Thyroid, Second Edition is a highly practical guide to neck biopsies that involve thyroid tissue. Presented in a reader-friendly format, it uses a pattern-based approach to the accurate interpretation of thyroid lesions – from normal anatomy and histology to a wide range of both common and unusual findings. Clinical implications of each diagnosis are highlighted throughout the text to guide therapeutic decision making.Key Features: Covers common thyroid biopsies, both cytology and surgical specimens, and uncommon lesions that may be mistaken for thyroid. Includes state-of-the-art information on immunohistochemistry, molecular diagnostics, and flow cytometry. Reviews the advantages and disadvantages of cytologic and histologic biops

Read more less

Book SynopsisTrade Review".I would highly recommend this book to all pathologists, especially those working towards the Part 2 exam. I believe it could be of educational value, whether you choose to read the text cover to cover, or use it to flick through and look at some of the beautifully presented images." -Dr Hannah Hawrot (Bulletin of the Royal College of Pathologists, January 2021)Table of Contents1 Cervical and Vaginal Cytology 2 Respiratory Tract and Mediastinum 3 Urine and Bladder Washings 4 Pleural, Pericardial, and Peritoneal Fluids 5 Peritoneal Washings 6 Cerebrospinal Fluid 7 Gastrointestinal Tract 8 Fine Needle Aspiration Biopsy Technique and Specimen Handling 9 Breast 10 Thyroid, 288 11 Salivary Gland 12 Lymph Nodes 13 Liver 14 Pancreas and Biliary Tree 15 Kidney and Adrenal Gland 16 Ovary, 520 17 Soft Tissue 18 Bone 19 Laboratory Management

Read more less

Book SynopsisTrade ReviewDoody's Core Titles® 2022 "I have reviewed previous editions of this book and I am as enthusiastic about this edition as I was about the previous ones. This is an ideal book for those starting to learn renal pathology as residents or even medical students. On the other hand, it also could serve well diagnostic pathologists who do not see too many renal biopsies in their daily practice or those who would like to learn about new developments in nephropathology. In its updated and expanded form, this book should be part pathology departmental libraries as well as central medical libraries." ©Doody's Review Service, 2022, Ivan Damjanov, MD,PhD (University of Kansas Medical Center)Table of Contents1. Approach to Diagnosis of the Kidney Biopsy 2. Normal Growth and Maturation 3. Glomerular Diseases 4. Vascular Diseases 5. Tubulointerstitial Diseases 6. Endemic Nephropathies 7. Chronic Kidney Disease 8. Renal Transplantation 9. Cystic Diseases of the Kidney 10. Renal Neoplasia

Read more less

Book SynopsisTrade ReviewDoody's Core Titles® 2022 "This book has grown since the fifth edition to maintain its standing as a comprehensive text. Yet, it remains an exceptionally well-organized, highly relevant, and immensely useful resource for practicing pathologists, oncologists, pathology trainees, and scientists alike." ©Doody's Review Service, 2022, Anna B Owczarczyk, MD, PHD (University of Michigan Medical School) Doody's Score: 4 Stars!Table of Contents1. Techniques of Immunohistochemistry: Principles, Pitfalls, and Standardization 2. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis 3. Immunohistology of Infectious Diseases 4. Immunohistology of Neoplasms of Soft Tissue and Bone 5. Immunohistology of Bone Marrow, Spleen and Histiocytic Disorders 6. Immunohistology of Lymph Node and Lymph Node Neoplasms 7. Immunohistology of Melanocytic Neoplasms 8. Immunohistology of Metastatic Carcinoma of Unknown Primary Site 9. Immunohistology of Head and Neck Lesions 10. Immunohistology of Endocrine Tumors 11. Immunohistology of the Mediastinum 12. Immunohistology of Lung and Pleural Neoplasms 13. Immunohistology of Skin Tumors 14. Immunohistology of the Gastrointestinal Tract 15. Immunohistology of Pancreas and Hepatobiliary Tract 16. Immunohistology of the Prostate 17. Immunohistology of the Bladder, Kidney, and Testis 18. Immunohistology of the Female Genital Tract 19. Immunohistology of the Breast 20. Immunohistology of the Nervous System 21. Immunocytology 22. Immunohistology of Pediatric Neoplasms 23. Imaging and Quantitative Immunohistochemistry

Read more less

Book SynopsisTrade Review"This is the third edition of the genitourinary volume in the popular Diagnostic Pathology series. It is a comprehensive reference and atlas for diseases involving the genitourinary tract. The previous edition was published in 2016." ©Doody's Review Service, 2023, Kyle Perry, MD (Henry Ford Health Systems) Doody's Score: 5 Stars!Table of ContentsSECTION 1: KIDNEY Introduction and Overview 4 Introduction to Renal Cell Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 10 Classification of Kidney Tumors and Tumor-Like Lesions Satish K. Tickoo, MD and Victor E. Reuter, MD Familial Cancer Syndromes 12 von Hippel-Lindau Syndrome Satish K. Tickoo, MD and Victor E. Reuter, MD 16 Birt-Hogg-Dubé Syndrome Satish K. Tickoo, MD and Victor E. Reuter, MD 20 Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome Satish K. Tickoo, MD, Victor E. Reuter, MD, and Mahul B. Amin, MD 24 Tuberous Sclerosis Complex Satish K. Tickoo, MD and Victor E. Reuter, MD 28 Succinate Dehydrogenase Complex Deficiency Syndrome Satish K. Tickoo, MD and Victor E. Reuter, MD 32 Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes Satish K. Tickoo, MD and Victor E. Reuter, MD Nonneoplastic Lesions 38 Renal Tuberculosis, Xanthogranulomatous Pyelonephritis, Renal Malakoplakia Satish K. Tickoo, MD and Victor E. Reuter, MD Renal Cell Tumors, Benign 44 Papillary Adenoma Satish K. Tickoo, MD and Victor E. Reuter, MD 48 Renal Oncocytoma Satish K. Tickoo, MD and Victor E. Reuter, MD Renal Cell Carcinoma 54 Clear Cell Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 64 Multilocular Cystic Renal Neoplasm of Low Malignant Potential Satish K. Tickoo, MD and Victor E. Reuter, MD 68 Clear Cell Renal Cancers With Fibromyomatous Stroma, Including ELOC (Formerly TCEB1) Mutated Renal Cell Carcinoma Judy Sarungbam, MD, Satish K. Tickoo, MD, and Victor E. Reuter, MD 74 Clear Cell Papillary Renal Cell Tumor Satish K. Tickoo, MD and Victor E. Reuter, MD 82 Papillary Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 92 Chromophobe Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 100 Collecting Duct Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 106 SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 112 TFE3- and TFEB-Rearranged Renal Cell Carcinomas Satish K. Tickoo, MD and Victor E. Reuter, MD 120 Mucinous Tubular and Spindle Cell Carcinoma Satish K. Tickoo, MD, Yingbei Chen, MD, and Victor E. Reuter, MD 126 Tubulocystic Renal Cell Carcinoma Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD 130 Thyroid-Like Follicular Carcinoma of Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD 134 Acquired Cystic Disease-Associated Renal Cell Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 140 Fumarate Hydratase-Deficient Renal Cell Carcinoma Jatin S. Gandhi, MD and Mahul B. Amin, MD 144 ALK Rearrangement-Associated Renal Cell Carcinoma Jatin S. Gandhi, MD and Mahul B. Amin, MD 148 Eosinophilic Solid and Cystic Renal Cell Carcinoma Jatin S. Gandhi, MD and Mahul B. Amin, MD 150 Other Eosinophilic/Oncocytic Tumors, Including ESC, EVT, and LOT Satish K. Tickoo, MD and Victor E. Reuter, MD 154 Subsequent 2nd Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 158 Renal Cell Carcinoma, Not Otherwise Specified Satish K. Tickoo, MD and Victor E. Reuter, MD Metanephric Tumors 162 Metanephric Adenoma Satish K. Tickoo, MD and Victor E. Reuter, MD 168 Metanephric Tumors Other Than Metanephric Adenoma Satish K. Tickoo, MD and Victor E. Reuter, MD Nephroblastic Tumors 172 Nephrogenic Rests Satish K. Tickoo, MD and Victor E. Reuter, MD 176 Nephroblastoma (Wilms Tumor) Satish K. Tickoo, MD and Victor E. Reuter, MD 186 Cystic Partially Differentiated Nephroblastoma Satish K. Tickoo, MD and Victor E. Reuter, MD Mesenchymal Tumors 188 Angiomyolipoma Satish K. Tickoo, MD and Victor E. Reuter, MD 194 Epithelioid Angiomyolipoma/Epithelioid PEComa Satish K. Tickoo, MD and Victor E. Reuter, MD 200 Congenital Mesoblastic Nephroma Satish K. Tickoo, MD and Victor E. Reuter, MD 204 Clear Cell Sarcoma of Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD 208 Rhabdoid Tumor of Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD Mixed Mesenchymal and Epithelial Tumors 212 Mixed Epithelial and Stromal Tumor (MEST) Family Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 220 Pediatric Cystic Nephroma Satish K. Tickoo, MD and Victor E. Reuter, MD 224 Synovial Sarcoma Satish K. Tickoo, MD and Victor E. Reuter, MD Neuroendocrine Tumors 228 Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma Satish K. Tickoo, MD and Victor E. Reuter, MD 232 Renal Ewing Sarcoma Satish K. Tickoo, MD and Victor E. Reuter, MD Hematopoietic Tumors 236 Hematopoietic Tumors Satish K. Tickoo, MD, Judy Sarungbam, MD, and Victor E. Reuter, MD Metastatic and Other Tumors 242 Juxtaglomerular Cell Tumor (Reninoma) Satish K. Tickoo, MD and Victor E. Reuter, MD 246 Renomedullary Interstitial Cell Tumor Satish K. Tickoo, MD and Victor E. Reuter, MD 250 Other Rare Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD 258 Metastatic Tumors Satish K. Tickoo, MD and Victor E. Reuter, MD Immunohistochemical Profiles for Tumors Involving Kidney 262 Immunohistochemistry, Kidney Satish K. Tickoo, MD and Victor E. Reuter, MD SECTION 2 Introduction and Overview 270 Classification of Bladder Tumors and Tumor-Like Lesions Steven Christopher Smith, MD, PhD Microscopic Anatomy 272 Microscopic Anatomy of Urinary Bladder Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 276 Microscopic Anatomy of Urethra Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 280 Microscopic Anatomy of Ureter Steven Christopher Smith, MD, PhD 282 Microscopic Anatomy of Renal Pelvis Steven Christopher Smith, MD, PhD Nonneoplastic Lesions of Urinary Tract 286 Overview of Cystitis Steven Christopher Smith, MD, PhD 292 Polypoid Cystitis Steven Christopher Smith, MD, PhD 300 Malakoplakia Steven Christopher Smith, MD, PhD 306 Schistosomiasis Steven Christopher Smith, MD, PhD 308 von Brunn Nests Steven Christopher Smith, MD, PhD 314 Nephrogenic Adenoma (Metaplasia) Steven Christopher Smith, MD, PhD 322 Fibroepithelial Polyp Steven Christopher Smith, MD, PhD 326 Prostatic-Type Polyp (Ectopic Prostate) Steven Christopher Smith, MD, PhD 330 Amyloidosis Steven Christopher Smith, MD, PhD 332 Müllerian Lesions Steven Christopher Smith, MD, PhD 336 Pseudocarcinomatous Hyperplasia Steven Christopher Smith, MD, PhD 344 Hamartoma Steven Christopher Smith, MD, PhD Urothelial Neoplasms, General 346 Overview of Urinary Bladder Neoplasms Hikmat Al-Ahmadie, MD Flat Urothelial Lesions 350 Urothelial Carcinoma In Situ Steven Christopher Smith, MD, PhD 358 Flat Urothelial Lesions Other Than Carcinoma In Situ Steven Christopher Smith, MD, PhD UROTHELIAL NEOPLASMS, NONINVASIVE 362 Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia) Jatin S. Gandhi, MD and Mahul B. Amin, MD 364 Urothelial Papilloma Steven Christopher Smith, MD, PhD 370 Papillary Urothelial Neoplasm of Low Malignant Potential Steven Christopher Smith, MD, PhD 374 Low-Grade Papillary Urothelial Carcinoma Hikmat Al-Ahmadie, MD 378 High-Grade Papillary Urothelial Carcinoma Hikmat Al-Ahmadie, MD 384 Inverted Urothelial Neoplasia Steven Christopher Smith, MD, PhD Urothelial Neoplasms, Invasive 394 Invasive Urothelial Carcinoma Hikmat Al-Ahmadie, MD 404 Urothelial Carcinoma, Subtypes and Divergent Differentiation Steven Christopher Smith, MD, PhD Glandular Lesions 426 Cystitis Cystica et Glandularis Hikmat Al-Ahmadie, MD 430 Villous Adenoma Hikmat Al-Ahmadie, MD 432 Invasive Adenocarcinoma Hikmat Al-Ahmadie, MD 438 Clear Cell Adenocarcinoma Hikmat Al-Ahmadie, MD Squamous Lesions 444 Squamous Proliferations Other Than Carcinoma Hikmat Al-Ahmadie, MD 448 Invasive Squamous Cell Carcinoma Hikmat Al-Ahmadie, MD Mesenchymal Lesions 454 Myofibroblastic Proliferations Steven Christopher Smith, MD, PhD 462 Smooth Muscle Tumors Steven Christopher Smith, MD, PhD 470 Rhabdomyosarcoma Steven Christopher Smith, MD, PhD 476 Other Mesenchymal Tumors Steven Christopher Smith, MD, PhD Other Tumors of Urinary Bladder 484 Paraganglioma Steven Christopher Smith, MD, PhD 492 Metastatic/Secondary Involvement of Bladder Steven Christopher Smith, MD, PhD Diverticula of Urinary Tract 500 Diverticula Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 504 Diverticular-Associated Neoplasia Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD URETHRA 508 Inflammatory Lesions of Urethra Steven Christopher Smith, MD, PhD 512 Carcinoma of Urethra Steven Christopher Smith, MD, PhD 516 Other Tumors and Tumor-Like Lesions of Urethra Steven Christopher Smith, MD, PhD URETER 520 Urothelial Carcinoma of Ureter Hikmat Al-Ahmadie, MD 524 Other Tumors and Tumor-Like Lesions of Ureter Hikmat Al-Ahmadie, MD RENAL PELVIS 530 Urothelial Carcinoma of Renal Pelvis Hikmat Al-Ahmadie, MD 540 Other Tumors and Tumor-Like Lesions of Renal elvis Hikmat Al-Ahmadie, MD Urachs 546 Urachal Remnants Steven Christopher Smith, MD, PhD 548 Tumors of Urachus Steven Christopher Smith, MD, PhD Immunohistochemical Profiles for Tumors Involving Urinary Bladder 554 Immunohistochemistry, Urinary Tract Steven Christopher Smith, MD, PhD SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE Introduction and Overview 562 Classification of Prostate Tumors and Tumor-Like Lesions Gladell P. Paner, MD, (BS) MT 564 General Concepts, Prostate Gladell P. Paner, MD, (BS) MT 570 Microanatomy and Zonal Variations Gladell P. Paner, MD, (BS) MT 580 Imaging Considerations for Pathologists Steven Christopher Smith, MD, PhD NONNEOPLASTIC LESIONS 584 Prostatitis Steven Christopher Smith, MD, PhD 588 Prostate Hyperplasia Gladell P. Paner, MD, (BS) MT 596 Adenosis Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 600 Atrophy and Its Patterns Gladell P. Paner, MD, (BS) MT 606 Hyperplasia of Mesonephric Remnants Steven Christopher Smith, MD, PhD 610 Verumontanum Mucosal Gland Hyperplasia Gladell P. Paner, MD, (BS) MT and Deepika Sirohi, MD 612 Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra Gladell P. Paner, MD, (BS) MT PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS 620 Prostatic Intraepithelial Neoplasia Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD Prostate Neoplasms 630 General Concepts, Prostate Carcinoma Steven Christopher Smith, MD, PhD 638 Acinar Adenocarcinoma Gladell P. Paner, MD, (BS) MT 656 Acinar Adenocarcinoma Subtypes and Patterns Gladell P. Paner, MD, (BS) MT 668 Atypical Small Acinar Proliferations Steven Christopher Smith, MD, PhD 674 Intraductal Proliferations and Ductal Carcinoma Hikmat Al-Ahmadie, MD and Mahul B. Amin, MD 682 Ductal Adenocarcinoma Gladell P. Paner, MD, (BS) MT 690 Urothelial Carcinoma Involving Prostate Gland Steven Christopher Smith, MD, PhD 696 Prostate Carcinoma With Neuroendocrine Differentiation Steven Christopher Smith, MD, PhD 704 Adenoid Cystic (Basal Cell) Carcinoma of Prostate Steven Christopher Smith, MD, PhD 710 Sarcomatoid Carcinoma of Prostate Steven Christopher Smith, MD, PhD 716 Carcinomas With Squamous Differentiation Gladell P. Paner, MD, (BS) MT 722 Cystic Epithelial Tumors of Prostate Gladell P. Paner, MD, (BS) MT

Read more less

Book SynopsisTable of ContentsPART ONE: Central Concepts of Pathophysiology: Cells and Tissues UNIT I: The Cell 1 Cellular Biology 2 Altered Cellular and Tissue Biology: Environmental Agents 3 The Cellular Environment: Fluids and Electrolytes, Acids and Bases UNIT II Genes, Gene-Environment Interaction, and Epigenetics 4 Genes and Genetic Diseases 5 Genes, Environment-Lifestyle, and Common Diseases 6 Epigenetics and Disease UNIT III Mechanisms of Self-Defense 7 Innate Immunity: Inflammation and Wound Healing 8 Adaptive Immunity 9 Alterations in Immunity 10 Infection 11 Stress and Disease UNIT IV Cellular Proliferation: Cancer 12 Cancer Biology 13 Cancer Epidemiology 14 Cancer in Children and Adolescents PART TWO: Pathophysiologic Alterations: Organs and Systems UNIT V The Neurologic System 15 Structure and Function of the Neurologic System 16 Pain, Temperature Regulation, Sleep, and Sensory Function 17 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function 18 Alterations of the Brain, Spinal Cord, and Peripheral Nerves 19 Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, Posttraumatic Stress Disorder, and Obsessive-Compulsive Disorder 20 Alterations of Neurologic Function in Children UNIT VI The Endocrine System 21 Mechanisms of Hormonal Regulation 22 Alterations of Hormonal Regulation 23 Obesity, Starvation, and Anorexia of Aging UNIT VII The Reproductive Systems 24 Structure and Function of the Reproductive Systems 25 Alterations of the Female Reproductive System 26 Alterations of the Male Reproductive System 27 Sexually Transmitted Infections UNIT VIII The Hematologic System 28 Structure and Function of the Hematologic System 29 Alterations of Hematologic Function 30 Alterations of Hematologic Function in Children UNIT IX The Cardiovascular and Lymphatic Systems 31 Structure and Function of the Cardiovascular and Lymphatic Systems 32 Alterations of Cardiovascular Function 33 Alterations of Cardiovascular Function in Children UNIT X The Pulmonary System 34 Structure and Function of the Pulmonary System 35 Alterations of Pulmonary Function 36 Alterations of Pulmonary Function in Children UNIT XI The Renal and Urologic Systems 37 Structure and Function of the Renal and Urologic Systems 38 Alterations of Renal and Urinary Tract Function 39 Alterations of Renal and Urinary Tract Function in Children UNIT XII The Digestive System 40 Structure and Function of the Digestive System 41 Alterations of Digestive Function 42 Alterations of Digestive Function in Children UNIT XIII The Musculoskeletal System 43 Structure and Function of the Musculoskeletal System 44 Alterations of Musculoskeletal Function 45 Alterations of Musculoskeletal Function in Children UNIT XIV The Integumentary System 46 Structure, Function, and Disorders of the Integument 47 Alterations of the Integument in Children UNIT XV Multiple Interacting Systems 48 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults 49 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children Glossary

Read more less

Book SynopsisTable of ContentsA Triumvirate: Correlating Thyroid Cytopathology, Molecular Testing, and Histopathology To Freeze or Not to Freeze? Recommendations for Intraoperative Examination and Gross Prosection of Thyroid Glands Challenges in Encapsulated Follicular-Patterned Tumors: How Much Is Enough? Evaluation of Nuclear Atypia, Architecture, and Invasion No Longer Well-Differentiated: Diagnostic Criteria and Clinical Importance of Poorly Differentiated/High-Grade Thyroid Carcinoma This is Your Thyroid on Drugs: Targetable Mutations and Fusions in Thyroid Carcinoma It Does Exist! Diagnosis and Management of Thyroid Carcinomas Originating in Struma Ovarii Preoperative, Intraoperative, and Postoperative Parathyroid Pathology: Clinical Pathologic Collaboration for Optimal Patient Management Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors and Familial Tumor Syndromes On the Chopping Block: Overview of DICER1 Mutations in Endocrine and Neuroendocrine Neoplasms Back to Biochemistry: Evaluation for and Prognostic Significance of SDH Mutations in Paragangliomas and Pheochromocytomas All Together Now: Standardization of Nomenclature for Neuroendocrine Neoplasms across Multiple Organs Light It Up! The Use of DOTATATE in Diagnosis and Treatment of Neuroendocrine Neoplasms Scarless Surgery: Clinical Indications for Transoral Endocrine Surgery and Implications for Pathologists Applications of Deep Learning in Endocrine Neoplasms

Read more less

Book SynopsisBiopsy Pathology in Colorectal Disease shows how the practising pathologist can extract the maximum of diagnostic value from biopsies of the colon, rectum and anus. With the advances in colonoscopic mucosal biopsy techniques these are amongst the most frequently encountered specimens in hospital histopathology departments. This new edition provides practising pathologists and those in allied disciplines with a thorough guide to the diagnosis of colorectal conditions, both common and rare, and offers expert guidance in the handling of biopsy specimens. The most valuable information for diagnostic interpretation of the various types of inflammatory disease is presented clearly and succinctly, minimizing the use of non-diagnostic terms such as non-specific colitis. Optimal ways of handling and examining polyps, the assessment of biopsies in motility disorders and the interpretation of biopsies of anal lesions are described. A rational classification and practical approach to dysplasia is presented. The early chapters describe how to recognize the many different features, both normal and abnormal, which can be regarded as signposts to diagnosis. The significance of these diagnostic signposts is briefly described and cross referenced to later chapters, in which the histological features of the specific diseases are covered in greater depth.Trade Review"This book fulfils the needs of all clinicians and pathologists having to deal with various colorectal conditions, both common and rare, that are looking for an expert guidance for the diagnosis." Dr P Kitsanta, ACP News"This book is a must-keep and a worthy successor to the first edition ... One would hope that all surgical pathologists, whether practitioner or academic, residents or fellows, would read this superb publication." Gregory Y. Lauwers, Archives of Pathology and Laboratory MedicineTable of Contents1. Introduction2. Normal features3. Assessment of abnormalities: diagnostic signposts4. Infective colitis5. Ulcerative colitis6. Crohn's disease7. Ileoanal pouch pathology8. Pseudomembranous colitis9. Microscopic - colitis collagenous colitis, lymphocytic colitis and their variants10. Ischaemic colitis11. Iatrogenic disease12. The differential diagnosis of inflammatory bowel disease13. Disorders of motility14. Neoplasia in the colon and rectum and its classification15. Polyps16. The diagnosis of malignancy17. Dysplasia in inflammatory bowel disease18. Malignant tumours19. Anal biopsy20. Miscellaneous conditions

Read more less

Book SynopsisDeath Investigation: A Field Guide, Second Edition is updated and expanded to include a chronological analysis of the death scene investigative process from the first notification to the autopsy and final report. This book is written for the standpoints of a forensic pathologist and a forensic toxicologist emphasizing essential elements of the death investigation and how the results impact the final cause and manner of death. Topics discussed include how to assess the body at the scene and how to properly investigate natural and unnatural deaths.The book discusses various means and causes of deaths, demonstrating how death manifests in various parts of the body. A section on traumatic injuries examines and illustrates with color photographs blunt force, sharp force, gunshot wounds, and a host of other injuries that the investigator is likely to confront. Natural death conditions and disease are discussed in a separate chapter devoted to the most common mannerTable of Contents1. Philosophy and Approach to Death Scene Investigation 2. The Body and the Scene 3. Assessment of the Body at the Scene 4. Detailed Physical Assessment of the Body at the Scene 5. Medical Records, History, and Other Investigative Records 6. Natural Diseases and Death Investigation 7. Traumatic Injuries and Definitions 8. Identification Methods 9. Signs of Cardiopulmonary Resuscitation and Treatment 10. Signs of Previous Surgeries and Procedures 11.The Medical-Legal Autopsy 12. Toxicology in Death Investigations 13. Forensic Experts Appendix A: Medical Terminology Appendix B: Prescription Medicines

Read more less

Book SynopsisTable of ContentsSECTION 1: INTRODUCTION AND OVERVIEW 4 Introduction to Renal Pathology Robert B. Colvin, MD 24 Normal Kidney Structure Neeraja Kambham, MD and Anthony Chang, MD 36 Normal Kidney Development Sanjay Jain, MD, PhD 46 Kidney Biopsy Reports Surya V. Seshan, MD, Anthony Chang, MD, and Lynn D. Cornell, MD 48 Needle Biopsy: Evaluation for Adequacy Lynn D. Cornell, MD 52 Harmonized Nephropathology Terminology and Reporting Mark Haas, MD, PhD 54 Consensus Definitions of Light and Electron Microscopy Lesions Mark Haas, MD, PhD 58 Common Artifacts and Pitfalls Lynn D. Cornell, MD SECTION 2: GLOMERULAR DISEASES PODOCYTOPATHIES 66 Minimal Change Disease (Diffuse Podocytopathy) A. Brad Farris, III, MD, MBA and Astrid Weins, MD, PhD 74 Classification of Focal Segmental Glomerulosclerosis A. Brad Farris, III, MD, MBA and Astrid Weins, MD, PhD 78 Etiologic Classification of Focal Segmental Glomerulosclerosis Robert B. Colvin, MD 80 Focal Segmental Glomerulosclerosis, Primary A. Brad Farris, III, MD, MBA and Astrid Weins, MD, PhD 88 Focal Segmental Glomerulosclerosis, Adaptive (Secondary) A. Brad Farris, III, MD, MBA and Astrid Weins, MD, PhD 94 Collapsing Glomerulopathy A. Brad Farris, III, MD, MBA and Astrid Weins, MD, PhD MEMBRANOUS NEPHROPATHY AND VARIANTS 104 Introduction to Membranous Nephropathy Robert B. Colvin, MD and Anthony Chang, MD 112 Etiologies of Membranous Nephropathy Anthony Chang, MD and Robert B. Colvin, MD 114 Membranous Nephropathy Due to PLA2R1 Autoantibodies Anthony Chang, MD and Sanjeev Sethi, MD 120 Membranous Nephropathy Due to Non-PLA2R1 Autoantibodies Anthony Chang, MD and Sanjeev Sethi, MD 126 Membranous Nephropathy Associated With Systemic Disease Anthony Chang, MD 130 Membranous Nephropathy With Anti-TBM Antibodies Robert B. Colvin, MD 132 Podocyte Infolding Glomerulopathy Shane Meehan, MB, BCh IGA-RELATED GLOMERULONEPHRITIDES 134 Overview of IgA-Related Glomerular Diseases Shane Meehan, MB, BCh 138 IgA Nephropathy Lynn D. Cornell, MD, Robert B. Colvin, MD, and Ian Roberts, MBChB, FRCPath 152 IgA Vasculitis (Henoch-Schönlein Purpura) Anthony Chang, MD and Ian Roberts, MBChB, FRCPath 158 IgA Acute Glomerulonephritis Associated With Staphylococcus aureus Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath 162 Hepatic Disease With IgA Deposition Robert B. Colvin, MD SLE AND RELATED AUTOANTIBODYMEDIATED DISEASES 164 Systemic Lupus Erythematosus Shane Meehan, MB, BCh, Robert B. Colvin, MD, and Ingeborg M. Bajema, MD, PhD 182 Mixed Connective Tissue Disease A. Brad Farris, III, MD, MBA 184 Idiopathic Nonlupus Full-House Nephropathy Ingeborg M. Bajema, MD, PhD and Emilie Rijnink, MD, PhD 186 Mixed Cryoglobulinemic Glomerulonephritis A. Brad Farris, III, MD, MBA and Charles E. Alpers, MD ANTI-GBM DISEASES 192 Anti-GBM Glomerulonephritis Anthony Chang, MD 200 Atypical Anti-GBM Disease Lynn D. Cornell, MD COMPLEMENT-RELATED GLOMERULONEPHRITIDES 204 Classification of MPGN and Complement-Related Diseases Jean Hou, MD, Robert B. Colvin, MD, and Mark Haas, MD, PhD 210 Dense Deposit Disease Jean Hou, MD, Mark Haas, MD, PhD, and A. Brad Farris, III, MD, MBA 218 C3 Glomerulonephritis Jean Hou, MD, Lynn D. Cornell, MD, and Mark Haas, MD, PhD 226 C1q Nephropathy Neeraja Kambham, MD 232 C4 Glomerulopathy Sanjeev Sethi, MD and Lynn D. Cornell, MD 234 Immune Complex Membranoproliferative Glomerulonephritis Jean Hou, MD, A. Brad Farris, III, MD, MBA, and Mark Haas, MD, PhD MONOCLONAL IMMUNOGLOBULIN GLOMERULAR DISEASES 242 Introduction to Diseases With Monoclonal Immunoglobulin Deposits Robert B. Colvin, MD 246 Monoclonal Immunoglobulin Deposition Disease Lynn D. Cornell, MD 254 Proliferative Glomerulonephritis With Monoclonal IgG Deposits Lynn D. Cornell, MD 258 Membranous Nephropathy With Masked IgG-Kappa Deposits Christopher P. Larsen, MD and Tiffany Caza, MD, PhD 262 Type I Cryoglobulinemic Glomerulonephritis Evan Farkash, MD, PhD and Robert B. Colvin, MD 266 Waldenström Macroglobulinemia Anthony Chang, MD 268 Crystalglobulin Glomerulonephritis Mariam Priya Alexander, MD 270 Light Chain Crystalline Podocytopathy Lynn D. Cornell, MD AMYLOIDOSIS 272 Amyloidosis Classification A. Brad Farris, III, MD, MBA and Sanjeev Sethi, MD 278 AL/AH Amyloidosis A. Brad Farris, III, MD, MBA and Sanjeev Sethi, MD 284 AA Amyloidosis A. Brad Farris, III, MD, MBA and Sanjeev Sethi, MD 288 AFib Amyloidosis A. Brad Farris, III, MD, MBA and Sanjeev Sethi, MD 290 AGel Amyloidosis Sanjeev Sethi, MD 292 ALECT2 Amyloidosis Christopher P. Larsen, MD, Sanjeev Sethi, MD, and Tiffany Caza, MD, PhD 294 AApoAI Amyloidosis A. Brad Farris, III, MD, MBA and Sanjeev Sethi, MD 295 AApoAII Amyloidosis Robert B. Colvin, MD and Sanjeev Sethi, MD 296 AApoAIV Amyloidosis Sanjeev Sethi, MD 297 AApoCII Amyloidosis Sanjeev Sethi, MD 298 ATTR Amyloidosis A. Brad Farris, III, MD, MBA and Sanjeev Sethi, MD IDIOPATHIC FIBRILLARY GLOMERULOPATHIES 300 Diseases With Organized Deposits Robert B. Colvin, MD 304 Fibrillary Glomerulopathy Anthony Chang, MD and Mariam Priya Alexander, MD 310 Immunotactoid Glomerulopathy Anthony Chang, MD and Charles E. Alpers, MD 314 Fibronectin Glomerulopathy Neeraja Kambham, MD DIABETIC AND RELATED RENAL DISEASES 318 Diabetic Nephropathy Neeraja Kambham, MD and Ian Roberts, MBChB, FRCPath 328 Metabolic Syndrome/Obesity-Related Glomerular Disease Shane Meehan, MB, BCh 332 Idiopathic Nodular Glomerulopathy A. Brad Farris, III, MD, MBA and Ian Roberts, MBChB, FRCPath INFECTION-RELATED GLOMERULAR DISEASES 336 Overview of Infection-Related Glomerular Disease Shane Meehan, MB, BCh 340 Acute Poststreptococcal Glomerulonephritis A. Brad Farris, III, MD, MBA 348 Postinfectious Glomerulonephritis, Nonstreptococcal A. Brad Farris, III, MD, MBA 354 Glomerulonephritis of Chronic Infection, Including Shunt Nephritis A. Brad Farris, III, MD, MBA 356 Endocarditis A. Brad Farris, III, MD, MBA and Christie L. Boils, MD 360 Syphilis Shane Meehan, MB, BCh 362 Lyme Disease Neeraja Kambham, MD 364 COVID-19 Nephropathies Lynn D. Cornell, MD, Mariam Priya Alexander, MD, and Robert B. Colvin, MD 372 Hepatitis B Virus Anthony Chang, MD 376 Hepatitis C Virus Anthony Chang, MD and Charles E. Alpers, MD 382 HIV-Associated Nephropathy A. Brad Farris, III, MD, MBA 388 Miscellaneous HIV-Associated Renal Diseases A. Brad Farris, III, MD, MBA 394 Schistosomiasis Neeraja Kambham, MD 396 Filariasis Christie L. Boils, MD 397 Leishmaniasis Kerstin Amann, MD and Robert B. Colvin, MD DRUG-INDUCED GLOMERULAR DISEASES 398 Drug-Induced Minimal Change Disease Anthony Chang, MD and Astrid Weins, MD, PhD 400 Bisphosphonate-Induced Collapsing Glomerulopathy A. Brad Farris, III, MD, MBA and Astrid Weins, MD, PhD 401 Chloroquine Toxicity Shane Meehan, MB, BCh 402 Antihepatitis C Virus Drugs Ivy A. Rosales, MD 406 Anti-EGFR Drugs Kammi J. Henriksen, MD GENETIC GLOMERULAR DISEASES 408 Classification of Glomerular Genetic Diseases Sanjay Jain, MD, PhD 410 Genetic Causes of Nephrotic Syndrome Joseph P. Gaut, MD, PhD GENETIC DISEASES OF GBM COLLAGEN 414 Alport Syndrome Joseph P. Gaut, MD, PhD, Helen Liapis, MD, and Robert B. Colvin, MD 426 Thin Basement Membrane Disease Joseph P. Gaut, MD, PhD and Helen Liapis, MD GENETIC PODOCYTE DISEASES 428 Congenital Nephrotic Syndrome of Finnish Type Joseph P. Gaut, MD, PhD and Helen Liapis, MD 432 Pierson Syndrome Nidia Messias, MD, Joseph P. Gaut, MD, PhD, and Helen Liapis, MD 434 Galloway-Mowat Syndrome Carrie L. Phillips, MD and Stephen M. Bonsib, MD 436 Denys-Drash Syndrome Kammi J. Henriksen, MD and Stephen M. Bonsib, MD 440 Frasier Syndrome Carrie L. Phillips, MD and Stephen M. Bonsib, MD 442 Podocin Deficiency Joseph P. Gaut, MD, PhD and Helen Liapis, MD 444 a-Actinin-4 Deficiency Joseph P. Gaut, MD, PhD and Helen Liapis, MD 446 Autosomal Dominant FSGS Due to INF2 Mutations Robert B. Colvin, MD 448 APOL1-Related Glomerular Disease Christopher P. Larsen, MD and Tiffany Caza, MD, PhD 452 Schimke Immunoosseous Dysplasia Shane Meehan, MB, BCh GENETIC STORAGE AND LIPID DISEASES 454 Fabry Disease Robert B. Colvin, MD and Laura Barisoni, MD 462 Alagille Syndrome Anthony Chang, MD 464 Lecithin Cholesterol Acyltransferase Deficiency Carrie L. Phillips, MD and Stephen M. Bonsib, MD 468 APOE Lipoprotein Glomerulopathy Joseph P. Gaut, MD, PhD and Helen Liapis, MD 470 Type III Hyperlipoproteinemia Nidia Messias, MD, Joseph P. Gaut, MD, PhD, and Helen Liapis, MD 472 I-Cell Disease (Mucolipidosis II) Carrie L. Phillips, MD and Stephen M. Bonsib, MD 474 Gaucher Glomerulopathy A. Brad Farris, III, MD, MBA OTHER GENETIC GLOMERULAR DISEASES 476 Type III Collagen Glomerulopathy Nidia Messias, MD, L. Nicholas Cossey, MD, and Helen Liapis, MD 480 Nail-Patella Syndrome Nidia Messias, MD and Helen Liapis, MD 482 Glomerulopathy of Hereditary Multiple Exostoses Robert B. Colvin, MD and Ian Roberts, MBChB, FRCPath MISCELLANEOUS GLOMERULAR DISEASES 484 Cryofibrinogenic Glomerulopathy Lynn D. Cornell, MD and Mariam Priya Alexander, MD 488 IgM Nephropathy Neeraja Kambham, MD 490 Kidney Disease Associated With COVID-19 Immunization Astrid Weins, MD, PhD and Robert B. Colvin, MD 494 Renal Disease in Rheumatoid Arthritis Neeraja Kambham, MD 500 Hemophagocytic Glomerulopathy Lynn D. Cornell, MD 504 Coenzyme-Q Nephropathies Laura Barisoni, MD 506 Hepatic Glomerulosclerosis Robert B. Colvin, MD 507 Intravascular Large B-Cell Lymphoma Anthony Chang, MD SECTION 3: VASCULAR DISEASES 510 Overview and Classification of Systemic Vasculitides Surya V. Seshan, MD and Ingeborg M. Bajema, MD, PhD ANCA DISEASES 520 ANCA-Related Glomerulonephritis Surya V. Seshan, MD and Ingeborg M. Bajema, MD, PhD 526 Microscopic Polyangiitis Surya V. Seshan, MD and Ingeborg M. Bajema, MD, PhD 534 Granulomatosis With Polyangiitis Surya V. Seshan, MD and Ingeborg M. Bajema, MD, PhD 544 Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Surya V. Seshan, MD and Ingeborg M. Bajema, MD, PhD 550 Drug-Induced ANCA Vasculitis Surya V. Seshan, MD and Ingeborg M. Bajema, MD, PhD NON-ANCA VASCULITIDES 554 Polyarteritis Nodosa Surya V. Seshan, MD 560 Kawasaki Disease Surya V. Seshan, MD and Yael K. Heher, MD, MPH, FRCP(C) 562 Giant Cell Arteritis Surya V. Seshan, MD 566 Takayasu Arteritis Surya V. Seshan, MD 570 Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis) Robert B. Colvin, MD THROMBOTIC MICROANGIOPATHIES 572 Introduction to Thrombotic Microangiopathies Neeraja Kambham, MD and Ivy A. Rosales, MD 578 Infection-Related Hemolytic Uremic Syndrome Neeraja Kambham, MD and Ivy A. Rosales, MD 584 Genetic Thrombotic Microangiopathy Neeraja Kambham, MD and Ivy A. Rosales, MD 588 Autoimmune Thrombotic Microangiopathy Neeraja Kambham, MD and Ivy A. Rosales, MD 592 Drug-Induced Thrombotic Microangiopathy Neeraja Kambham, MD and Ivy A. Rosales, MD 596 Postpartum Hemolytic Uremic Syndrome Neeraja Kambham, MD and Ivy A. Rosales, MD 600 Scleroderma Renal Disease Neeraja Kambham, MD and Ivy A. Rosales, MD 606 Multicentric Castleman Disease Lynn D. Cornell, MD OTHER DISEASES AFFECTING ENDOTHELIUM 608 Preeclampsia, Eclampsia, and HELLP Syndrome Anthony Chang, MD 610 Radiation Nephropathy Anthony Chang, MD 612 Sickle Cell Nephropathy Anthony Chang, MD 616 Retinal Vasculopathy and Cerebral Leukodystrophy Robert B. Colvin, MD HYPERTENSIVE RENAL DISEASES 618 Hypertensive Renovascular Diseases A. Brad Farris, III, MD, MBA 626 Renal Artery Stenosis A. Brad Farris, III, MD, MBA 630 Fibromuscular Dysplasia A. Brad Farris, III, MD, MBA 636 Neurofibromatosis Kammi J. Henriksen, MD and Stephen M. Bonsib, MD THROMBOTIC AND EMBOLIC DISEASES 640 Renal Vein Thrombosis Anthony Chang, MD and Yael K. Heher, MD, MPH, FRCP(C) 642 Renal Artery Thrombosis Anthony Chang, MD 644 Atheromatous Emboli Anthony Chang, MD 646 Hydrophilic Polymer Emboli Kammi J. Henriksen, MD SECTION 4: TUBULOINTERSTITIAL DISEASES 650 Overview and Classification of Tubulointerstitial Diseases Robert B. Colvin, MD 652 Differential Diagnosis of Acute Interstitial Nephritis Lynn D. Cornell, MD 658 Granulomatous Interstitial Nephritis Ivy A. Rosales, MD 662 Guide to Crystal Nephropathies L. Nicholas Cossey, MD ISCHEMIC INJURIES 668 Acute Tubular Injury Shane Meehan, MB, BCh 674 Renal Cortical Necrosis Shane Meehan, MB, BCh 676 Sepsis/Shock Joseph P. Gaut, MD, PhD IMMUNOLOGIC TUBULAR DISEASES 678 IgG4-Related Disease Lynn D. Cornell, MD 688 Sjögren Syndrome Josephine M. Ambruzs, MD, MPH 692 Tubulointerstitial Nephritis and Uveitis A. Brad Farris, III, MD, MBA 696 Sarcoidosis Josephine M. Ambruzs, MD, MPH 700 Antibrush Border Autoantibody Tubulointerstitial Nephritis Ivy A. Rosales, MD and Robert B. Colvin, MD 702 Anti-TBM Disease Robert B. Colvin, MD 704 Tubulointerstitial Nephritis With IgM(+) Plasma Cells Lynn D. Cornell, MD MONOCLONAL IMMUNOGLOBULIN TUBULOINTERSTITIAL DISEASES 706 Light Chain Cast Nephropathy Anthony Chang, MD and Kammi J. Henriksen, MD 712 Light Chain Proximal Tubulopathy With Crystals Lynn D. Cornell, MD 716 Light Chain Proximal Tubulopathy Without Crystals Christopher P. Larsen, MD and Tiffany Caza, MD, PhD 720 Crystal-Storing Histiocytosis Mariam Priya Alexander, MD DRUG-INDUCED TUBULOINTERSTITIAL DISEASES 724 Drug-Induced Acute Interstitial Nephritis Lynn D. Cornell, MD and Robert B. Colvin, MD 730 Drugs That Cause Tubulointerstitial Nephritis Robert B. Colvin, MD and Lynn D. Cornell, MD 732 Checkpoint Inhibitor-Induced Kidney Diseases Ivy A. Rosales, MD 736 Papillary Necrosis Neeraja Kambham, MD 740 Cisplatin Nephrotoxicity Shane Meehan, MB, BCh 742 Osmotic Tubulopathy Shane Meehan, MB, BCh and Evan Farkash, MD, PhD 746 Antiviral Drug Nephrotoxicity Shane Meehan, MB, BCh 752 Acute Phosphate Nephropathy Lynn D. Cornell, MD 754 Lithium-Induced Renal Disease Anthony Chang, MD and Yael K. Heher, MD, MPH, FRCP(C) 756 Calcineurin Inhibitor Toxicity Shane Meehan, MB, BCh 762 mTOR Inhibitor Toxicity Lynn D. Cornell, MD 764 Vancomycin-Induced Cast Nephropathy Kammi J. Henriksen, MD 766 Anticoagulant-Related Nephropathy Christopher P. Larsen, MD and Tiffany Caza, MD, PhD 768 Illicit Drugs and Opioids Kammi J. Henriksen, MD TOXIC TUBULOPATHIES 770 Myoglobinuria/Rhabdomyolysis/Hemoglobinuria Neeraja Kambham, MD 772 Bile Cast Nephropathy Anthony Chang, MD 774 Lead and Other Heavy Metal Toxins Shane Meehan, MB, BCh 778 Ethylene Glycol Toxicity Shane Meehan, MB, BCh 780 Aristolochic Acid Nephropathy Shane Meehan, MB, BCh 782 Balkan Endemic Nephropathy Shane Meehan, MB, BCh 784 Argyria Robert B. Colvin, MD AUTOSOMAL DOMINANT TUBULOINTERSTITIAL KIDNEY DISEASES 786 MUC1-Related Autosomal Dominant Tubulointerstitial Kidney Disease Joseph P. Gaut, MD, PhD and Helen Liapis, MD 788 UMOD-Related Autosomal Dominant Tubulointerstitial Kidney Disease Shane Meehan, MB, BCh 790 REN-Related Autosomal Dominant Tubulointerstitial Kidney Disease Lynn D. Cornell, MD 792 HNF1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease Robert B. Colvin, MD and Marie Claire Gubler, MD GENETIC CRYSTAL DEPOSITION DISEASES 794 Uric Acid Nephropathy/Gout Shane Meehan, MB, BCh 798 Primary Hyperoxaluria Shane Meehan, MB, BCh 800 2,8-Dihydroxyadeninuria Lynn D. Cornell, MD 802 Cystinosis Nidia Messias, MD, Joseph P. Gaut, MD, PhD, and Helen Liapis, MD GENETIC TRANSPORT DISEASES 804 Bartter Syndrome Shane Meehan, MB, BCh 806 Dent Disease Lynn D. Cornell, MD 808 Oculocerebrorenal Syndrome of Lowe Josephine M. Ambruzs, MD, MPH OTHER GENETIC TUBULAR DISEASES 810 Mitochondriopathies Surya V. Seshan, MD 814 Systemic Karyomegaly Robert B. Colvin, MD 816 Methylmalonic Acidemia Lynn D. Cornell, MD and Linda Hasadsri, MD, PhD MISCELLANEOUS TUBULOINTERSTITIAL DISEASES 820 Nephrocalcinosis Lynn D. Cornell, MD 822 Lysozyme Nephropathy Tiffany Caza, MD, PhD and Christopher P. Larsen, MD 824 Secondary Oxalosis Lynn D. Cornell, MD 826 Chronic Interstitial Nephritis in Agricultural Communities Lynn D. Cornell, MD 828 Extramedullary Hematopoiesis Lynn D. Cornell, MD SECTION 5: KIDNEY INFECTIONS BACTERIAL INFECTIONS 834 Acute Pyelonephritis Neeraja Kambham, MD 842 Chronic Pyelonephritis Neeraja Kambham, MD 846 Xanthogranulomatous Pyelonephritis Neeraja Kambham, MD and Ivy A. Rosales, MD 850 Malakoplakia Neeraja Kambham, MD 854 Tuberculosis Neeraja Kambham, MD 856 BCG Granulomatous Interstitial Nephritis Neeraja Kambham, MD 858 Leprosy Neeraja Kambham, MD 859 Megalocytic Interstitial Nephritis Neeraja Kambham, MD 860 Nocardiosis Neeraja Kambham, MD 862 Leptospirosis Shane Meehan, MB, BCh 864 Whipple Disease Carrie L. Phillips, MD FUNGAL, RICKETTSIAL, AND PARASITIC INFECTIONS 866 Mucormycosis Anthony Chang, MD 868 Candidiasis Anthony Chang, MD 869 Histoplasmosis Anthony Chang, MD 870 Coccidioidomycosis Anthony Chang, MD 871 Blastomycosis Anthony Chang, MD 872 Paracoccidioidomycosis Anthony Chang, MD 873 Aspergillosis Anthony Chang, MD 874 Cryptococcosis Anthony Chang, MD 875 Microsporidiosis Robert B. Colvin, MD 876 Rickettsial Infections Shane Meehan, MB, BCh 878 Toxoplasmosis Neeraja Kambham, MD 880 Hydatidosis Carrie L. Phillips, MD and Stephen M. Bonsib, MD VIRAL INFECTIONS 882 Polyomavirus Nephritis Anthony Chang, MD and Evan Farkash, MD, PhD 890 Cytomegalovirus Infection Anthony Chang, MD and R. Neal Smith, MD, PhD 892 Adenovirus Infection Anthony Chang, MD and R. Neal Smith, MD, PhD 894 Epstein-Barr Virus Nephritis Anthony Chang, MD and R. Neal Smith, MD, PhD 896 Herpes Simplex Acute Nephritis Anthony Chang, MD and R. Neal Smith, MD, PhD 898 Hantavirus Nephropathy A. Brad Farris, III, MD, MBA SECTION 6: DEVELOPMENTAL DISEASES 902 Overview of Congenital Anomalies of Kidney and Urinary Tract Sanjay Jain, MD, PhD 906 Dysplasia/Hypoplasia/Agenesis Sanjay Jain, MD, PhD 912 Oligomeganephronia Robert B. Colvin, MD and Yael K. Heher, MD, MPH, FRCP(C) 914 Ectopia, Malrotation, Duplication, Fusion, Supernumerary Kidney Sanjay Jain, MD, PhD 918 Ask-Upmark Kidney Lynn D. Cornell, MD 920 Renal Tubular Dysgenesis Carrie L. Phillips, MD and Stephen M. Bonsib, MD SECTION 7: CYSTIC DISEASES 926 Overview of Cystic Diseases Nidia Messias, MD, Joseph P. Gaut, MD, PhD, and Helen Liapis, MD CILIOPATHIES 932 Autosomal Dominant Polycystic Kidney Disease Anthony Chang, MD, Robert B. Colvin, MD, and Yael K. Heher, MD, MPH, FRCP(C) 938 Autosomal Recessive Polycystic Kidney Disease Carrie L. Phillips, MD and Stephen M. Bonsib, MD 944 Nephronophthisis and Related Ciliopathies Kerstin Amann, MD, Helen Liapis, MD, and Robert B. Colvin, MD OTHER GENETIC CYSTIC DISEASES 950 von Hippel-Lindau Disease Carrie L. Phillips, MD and Stephen M. Bonsib, MD 956 Tuberous Sclerosis Complex Christie L. Boils, MD 962 Zellweger Syndrome Carrie L. Phillips, MD and Stephen M. Bonsib, MD MISCELLANEOUS CYSTIC DISEASES 964 Medullary Sponge Kidney Lynn D. Cornell, MD 966 Mixed Epithelial and Stromal Tumor Family Carrie L. Phillips, MD and Stephen M. Bonsib, MD 972 Pediatric Cystic Nephroma Angelica R. Putnam, MD and Carrie L. Phillips, MD 976 Acquired Cystic Disease Carrie L. Phillips, MD and Stephen M. Bonsib, MD 980 Simple and Miscellaneous Cysts Anthony Chang, MD 982 Renal Lymphangioma/Lymphangiectasia Carrie L. Phillips, MD and Stephen M. Bonsib, MD SECTION 8: COLLECTING SYSTEM DISEASES 988 Introduction to Impediments to Urine Flow Sanjay Jain, MD, PhD 992 Reflux Nephropathy Sanjay Jain, MD, PhD 996 Obstructive Uropathy Sanjay Jain, MD, PhD 1000 Nephrolithiasis Shane Meehan, MB, BCh 1006 Loin Pain Hematuria Syndrome Carrie L. Phillips, MD and Stephen M. Bonsib, MD SECTION 9: RENAL ALLOGRAFT DISEASES 1010 Pathologic Classification of Renal Allograft Diseases Robert B. Colvin, MD INTRODUCTION 1012 Evaluation of Allograft Kidneys Lynn D. Cornell, MD and Evan Farkash, MD, PhD 1018 Evaluation of Donor Kidneys Lynn D. Cornell, MD and Evan Farkash, MD, PhD REJECTION 1024 Acute T-Cell-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1034 Chronic T-Cell-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1038 Hyperacute Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1042 Acute Antibody-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1050 Chronic Antibody-Mediated Rejection Lynn D. Cornell, MD and Michael Mengel, MD 1062 Transcript Analysis of Renal Transplant Biopsies Michael Mengel, MD and R. Neal Smith, MD, PhD RECURRENT AND DE NOVO DISEASES 1066 Diseases That Recur in Allografts Anthony Chang, MD, Lynn D. Cornell, MD, and R. Neal Smith, MD, PhD 1072 De Novo Focal Segmental Glomerulosclerosis Anthony Chang, MD and Astrid Weins, MD, PhD 1074 De Novo Membranous Nephropathy Anthony Chang, MD 1078 Anti-GBM Disease in Alport Syndrome Anthony Chang, MD and R. Neal Smith, MD, PhD 1080 Chimerism Transition Syndrome A. Brad Farris, III, MD, MBA 1082 Late Posttransplant Histology Lynn D. Cornell, MD OTHER ALLOGRAFT DISEASES 1084 Acute Allograft Ischemia A. Brad Farris, III, MD, MBA 1088 Size Mismatch Allograft Injury Anthony Chang, MD and Yael K. Heher, MD, MPH, FRCP(C) 1090 Lymphocele A. Brad Farris, III, MD, MBA 1091 Transplant Renal Artery Stenosis A. Brad Farris, III, MD, MBA 1092 Transplant Renal Artery or Vein Thrombosis A. Brad Farris, III, MD, MBA 1094 Posttransplant Lymphoproliferative Diseases A. Brad Farris, III, MD, MBA 1104 BK Polyomavirus Neoplasia Evan Farkash, MD, PhD 1106 Protocol Biopsies Lynn D. Cornell, MD and Evan Farkash, MD, PhD 1110 Tolerance Robert B. Colvin, MD 1114 Kidney Xenografts Ivy A. Rosales, MD KIDNEY PATHOLOGY IN RECIPIENTS OF OTHER TRANSPLANTS 1118 Kidney Diseases in Nonrenal Transplant Recipients Robert B. Colvin, MD 1122 Graft-vs.-Host Glomerulopathies Anthony Chang, MD and Yael K. Heher, MD, MPH, FRCP(C) SECTION 10: KIDNEY EXAMINATION 1126 Examination of End-Stage Kidneys Shane Meehan, MB, BCh 1132 Examination of Tumor Nephrectomy Specimens for Nonneoplastic Diseases Kammi J. Henriksen, MD and Stephen M. Bonsib, MD 1136 Evaluation of Transplant Nephrectomies Shane Meehan, MB, BCh and Evan Farkash, MD, PhD 1140 Evaluation of Autopsy Kidneys Kammi J. Henriksen, MD and Mariam Priya Alexander, MD SECTION 11: TECHNIQUES 1146 Basic Concepts for Computational Image Analysis Laura Barisoni, MD and Andrew Janowczyk, PhD 1150 Artificial Intelligence and Digital Pathology Analysis of Kidneys A. Brad Farris, III, MD, MBA 1154 Evaluation of Fibrosis A. Brad Farris, III, MD, MBA 1158 Immunofluorescence on Paraffin Tissue Sections Nidia Messias, MD 1162 EM Processing From Paraffin Tissue A. Brad Farris, III, MD, MBA 1164 Detection of Autoantigens in Membranous Nephropathy Christopher P. Larsen, MD and A. Bernard Collins, BS 1168 Alport Collagen IV Immunofluorescence A. Bernard Collins, BS, Christopher P. Larsen, MD, and Robert B. Colvin, MD 1170 C4d Immunohistochemistry/Immunofluorescence Robert B. Colvin, MD and A. Bernard Collins, BS 1174 Polyomavirus Detection in Tissue Robert B. Colvin, MD 1176 Mass Spectrometry Sanjeev Sethi, MD and Mariam Priya Alexander, MD 1178 Diagnostic Genetics of Kidney Diseases Sanjay Jain, MD, PhD and Yasar Caliskan, MD

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Table of ContentsIntroduction Cell and Tissue Damage Genetic Disease Inflammation, Healing and Repair Haemdynamic Disorders, Thrombosis and Shock Infection and Immunity Neoplasia Cardiovascular Diseases Respiratory System Gastrointestinal Tract Liver, Gall Bladder and Pancreas Haemopoietic and Lympho-reticular Tissues Genitourinary System Female Genital System and Breast Nervous System Musculo-skeletal System Endocrine System

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThis book provides a practical guide for all those working in or with Medical Examiner Services in England and Wales. It is an adjunct to the e-learning and face-to-face training required to fulfil the Medical Examiner and Medical Examiner Officer roles.Medical Examiner Services also work closely with a wide range of stakeholders including bereavement and mortuary teams, Coroners and their Officers, Registrars, Funeral Directors and those working in clinical governance and patient safety. This book provides an essential overview of all aspects of the Medical Examiner system for anyone working in these areas, or in any aspect of the support and management of the deceased and bereaved. A concise guide including the knowledge base required to develop and run a Medical Examiner Service Content is completely aligned with required training Written by those with direct experience of establishing and working with Medical Examiner Services Relevant to a wide range of stakeholders who work with patients and the bereaved Table of ContentsBackground to the Medical Examiner Service in England & Wales. The Medical Examiner Service in England & Wales: Structure. The Role of the Regional Medical Examiner and Regional Medical Examiner Officer. The Role of the Medical Examiner. The Role of the Medical Examiner Officer. Completing a Medical Certificate of Cause of Death. Basics of Law for Medical Examiners & Medical Examiner Officers. Role of the Bereavement Service. The Role of the Registration Officer (Registrar). Role of the Coroner. Medical Examiner Service and its Relationship with Mortality Governance. The Medical Examiner Service in the Community. The Medical Examiner Service and Child Death Reviews. Law & Procedures Related to Burial & Cremation. Faith Implications of the Medical Examiner System. The Role of the Funeral Director. The Role of the Mortuary. The Medical Reviewer System in Scotland.

Read more less

Book SynopsisEstimation of the Time Since Death remains the foremost authoritative book on scientifically calculating the estimated time of death postmortem. Building on the success of previous editions which covered both the early and later postmortem periods this edition includes a new chapter on DNA/RNA degradation and further new content on drug testing in hair, thus widening the scope of the material. Chapters have been improved, updated and expanded, and include new and additional images to enhance the text. A unique work of synthesis combining rigorous science with practical guidance, this update reinforces the book's reputation as an invaluable resource and also the standard for the estimation of the time since death.Table of ContentsPreface to the Third Edition. Preface to the Fourth Edition. Editor Biography. List of Contributors. General Remarks on Estimating the Time Since Death. Historical Review on Early Work on Estimating the Time Since Death. Supravitality in Tissues. Rigor Mortis: Estimation of the Time Since Death by Evaluation of Cadaveric Rigidity. Post-mortem Lividity: Hypostasis and Timing of Death. Post-mortem Body Cooling and Temperature-Based Methods. Basics and Application of the ‘Nomogram Method’ at the Scene. Finite Element Method in Temperature-Based Death Time Determination. The Prism Method. The Use of Temperatures Recorded from the External Auditory Canal. for the Estimation of the Post-mortem Intervalt. Eye Temperature and the Time Since Death. Autolysis, Putrefactive Changes and Post-mortem Chemistry. Autolysis (Self-digestion). Eye Changes After Death. Potassium Levels Combined with Age and Temperature. Estimation of Time Since Death Based on Vitreous Humour Hypoxanthine and Temperature Measurement. Cerebrospinal Fluid Chemistry. Estimation of Duration of Immersion. H3-Magnetic Resonance Spectroscopy. Post-mortem Protein Degradation. DNA/RNA Degradation and Time Since Death. Gastric Contents and Time Since Death. Immunohistochemical Methods as an Aid in Estimating the Time Since Death. Practical Casework. Integration of Different Methods in Casework. Conditional Probability in Death Time Estimation. Forensic Entomology. Radiocarbon Dating: Basic Principles and Applications. Cross-Sectional Imaging and the Post-mortem Interval. Drug Testing in Hair for the Estimation of the Time Since Death. Index.

Read more less

Book SynopsisA 77-year-old man phones â999â after experiencing severe backache. The paramedics arrive to find him in severe pain, and cold and clammy. While at his house, they note that he smokes and also elicit a history of hypertension. He is tachycardic and hypotensive en route to hospital, and intravenous fluids are started. You have been assigned his initial assessment ...100 Cases in Clinical Pathology and Laboratory Medicine presents 100 clinical scenarios commonly seen by medical students and junior doctors in the emergency department, outpatient clinic, operating theatre or in general practice. A succinct summary of the patient's history, examination and initial investigations is followed by questions on each case, with particular emphasis on the interpretation of the results and in which an understanding of the underlying clinical pathology is central to arriving at the correct diagnosis. The answer includes a detailed discussion on each topic, providing an essential revision aid as well as a practical guide for students and junior doctors, especially those preparing for undergraduate and postgraduate examinations. Making speedy and appropriate clinical decisions, and choosing the best course of action to take as a result, is one of the most important and challenging parts of training to become a doctor. Fully revised and updated for this second edition, these true-to-life cases will teach students and junior doctors to recognize important clinical conditions, to request the appropriate pathological investigation and correctly interpret those results, and, as a result, to develop their diagnostic and management skills.Table of ContentsSection 1- LABORATORY MEDICINECase 1 POLYURIA AND POLYDIPSIACase 2 TRACES OF BLOOD FOUND ON URINE DIPSTICKCase 3 CONFUSION, LETHARGY AND SHORTNESS OF BREATHCase 4 A CHILD WITH FACIAL SWELLINGCase 5 JOINT PAINS AND FATIGUECase 6 ANXIETY, IRRITABILITY AND REDUCED MENSTRUAL FREQUENCYCase 7 SCREENING FOR PROSTATE CANCER?Case 8 A YOUNG WOMAN FOUND UNCONSCIOUS IN BEDCase 9 A MIDDLE-AGED WOMAN WITH JAUNDICECase 10 DRUG OVERDOSECase 11 FATIGUE, WEAKNESS AND CONSTIPATIONCase 12 EXCESSIVE HAIR GROWTH AND INFERTILITYCase 13 FATIGUE AND IRREGULAR PERIODSCase 14 STIFF AND PAINFUL HANDSCase 15 ABDOMINAL PAIN, NAUSEA AND VOMITINGCase 16 FREQUENT THROAT AND CHEST INFECTIONSCase 17 A ROUTINE ‘HEALTH CHECK’ FOR A 55-YEAR-OLD MANCase 18 COLLAPSE IN A PATIENT UNDERGOING CHEMOTHERAPYCase 19 A 10-DAY-OLD BABY WITH AMBIGUOUS GENITALIACase 20 FATIGUE, WEAKNESS AND WEIGHT GAINCase 21 HYPERTENSION IN A YOUNG WOMANCase 22 NAUSEA, VOMITING, WEAKNESS AND PARAETHESIACase 23 ERECTILE DYSFUNCTION IN A YOUNG MANCase 24 A YOUNG MAN WITH ‘HIGH CHOLESTEROL’Case 25 RASH AFTER A BONE MARROW TRANSPLANTCase 26 A FALL ON AN OUTSTRETCHED HANDCase 27 A PATIENT IN FOLLOW-UP AFTER A LIVER TRANSPLANTCase 28 A MAN WITH POORLY CONTROLLED BLOOD PRESSURECase 39 DIZZINESS ON STANDING UPRIGHTCase 30 SUDDEN-ONSET CHEST PAIN IN A TALL WOMANCase 31 CONCERNS ABOUT THE RISK OF BREAST CANCERCase 32 SEIZURE IN A NEONATECase 33 FLU -LIKE ILLNESS AFTER FOREIGN TRAVELSection 2- HISTOPATHOLOGY Case 34 A YOUNG WOMAN WITH ANKLE SWELLING AND SHORTNESS OF BREATHCase 35 CHEST PAIN AND SUDDEN DEATHCase 36 AN ELDERLY MAN WITH SEVERE BACK PAINCase 37 INCREASED BREATHLESSNESS AND SUDDEN DEATHCase 38 A WORSENING COUGH AND HAEMOPTYSISCase 39 A YOUNG MAN WITH SHORTNESS OF BREATH AND HAEMOPTYSISCase 40 SUDDEN ONSET WEAKNESS AND DYSPHASIACase 41 NUMBNESS, WEAKNESS AND CLUMSINESSCase 42 FORGETFULNESS AND DISORIENTATIONCase 43 COFFEE-GROUND VOMITINGCase 44 EPISODIC RIGHT UPPER QUADRANT ABDOMINAL PAINCase 45 CHRONIC DIARRHOEA AND FLATULENCECase 46 A YOUNG MAN WITH BLOODY DIARRHOEA Case 47 ABDOMINAL DISCOMFORT AND GENERALISED WEAKNESSCase 48 ABDOMINAL PAIN IN A PUBLICANCase 49 ABDOMINAL DISTENSION, LOSS OF APPETITE AND MALAISECase 50 BACK PAIN AND FEVER IN A DIABETICCase 51 URINARY PROBLEMS IN AN ELDERLY MANCase 52 A YOUNG MAN WITH A TESTICULAR LUMPCase 53 HEAVY AND PAINFUL MENSTRUAL BLEEDINGCase 54 ABNORXMAL VAGINAL BLEEDINGCase 55 A LUMP IN THE BREASTCase 56 LYMPH NODE ENLARGEMENT IN A YOUNG MANCase 57 AN ITCHY, BLEEDING MOLE ON THE BACKCase 58 BLOOD IN THE URINE IN AN ELDERLY MANCase 59 THYROID DISEASE IN A YOUNG WOMANSection 3 – HAEMATOLOGYCase 60 SHORTNESS OF BREATH AND HEARTBURNCase 61 RAISED WHITE CELL COUNT IN AN ASYMPTOMATIC INDIVIDUALCase 62 WORSENING FATIGUE AND BLEEDING GUMSCase 63 BURNING URINE AND AN ABNORMAL CLOTTING SCREENCase 64 HEADACHES, BLURRED VISION AND ITCHINGCase 65 A PAINFUL ARM AND A LARGE SPLEENCase 66 A RASH ON THE THIGHSCase 67 FATIGUE AND WEIGHT LOSSCase 68 PNEUMONIA WITH ABNORMAL LIVER FUNCTIONCase 69 RECURRENT EPISTAXISCase 70 BRUISING AFTER A PNEUMONIACase 71 HEADACHE AND A RASHCase 72 SHORTNESS OF BREATH AND WEIGHT LOSSCase 73 ANAEMIA RESISTANT TO A BLOOD TRANSFUSIONCase 74 ASYMPTOMATIC ANAEMIA IN THE ELDERLYCase 75 BACK PAIN AND FATIGUECase 76 SHORT OF BREATH AND UNDERWEIGHTCase 77 DETERIORATION AFTER A BLOOD TRANSFUSIONCase 78 HEADACHE AND BLURRED VISIONCase 79 LOWER BACK PAINSection 4 – MICROBIOLOGYCase 80 LEG PAIN AND FEVERSCase 81 FEVER AND COLLAPSECase 82 BURNING SENSATION WHEN PASSING URINECase 83 A BIT SHORT OF BREATHCase 84 UNHAPPY CAMPERCase 85 DIARRHOEA IN AN ELDERLY MANCase 86 A PAINFUL KNEECase 87 A PAIN IN THE EARCase 88 A RED EYECase 89 CHILD WITH A RASHCase 90 PELVIC PAINCase 91 A PAINFUL SWOLLEN JAWCase 92 TRAVELLER’S DIARRHOEACase 93 FEVER IN A RETURNING TRAVELLERCase 94 A SPOT OF CONFUSIONCase 95 CONGENITAL INFECTIONCase 96 A CHRONIC COUGHCase 97 A JAUNDICED VIEWCase 98 GRAM NEGATIVE BACTERAEMIACase 99 A GROIN SWELLINGCase 100 URETHRAL DISCHARGE

Read more less

Book SynopsisGreenfield's is the worldâs leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two-volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. This is a tried and tested reference for scientists, clinicians, researchers and students who wish to learn more about neurological disease.Volume Two is available as a single purchase as well as within the set, and it covers Infections of the Nervous System, Nutritional and Toxic Disorders, Neurotrauma, Neuro-oncology, Psychiatric and Neurodevelopmental Disorders and Neuromuscular Disorders.The tenth edition features fully updated sections throughout. Global coverage from an international team of editors and contributors. Fully downloadable and easily useable e-version included.

Read more less

Book SynopsisFor around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.Table of ContentsForeword Zev Rosenwaks; 1. In-vitro fertilization and micromanipulation: The history that changed the treatment of male factor infertility Jacques Cohen; 2. Development of ICSI in human assisted reproduction Stephanie Cheung, Alessandra Parrella, Philip Xie, Sherina Lawrence, Mounia Haddad, Derek Keating, Zev Rosenwaks and Gianpiero D. Palermo; 3. Current ICSI applications and clinical outcomes Derek Keating, Stephanie Cheung, Philip Xie, June Wang, Zev Rosenwaks and Gianpiero D. Palermo; 4. Rescue ICSI of IVF failed-fertilized oocytes Carly Barber, Vivian Nguyen, Alexandrea Ramsey and Zsolt Peter Nagy; 5. High-magnification sperm selection before ICSI Pierre Vanderzwalmen, Barbara Wirleitner, Guy Cassuto, Romain Imbert and Maximillian Murtinger; 6. Laser-assisted ICSI Roberta Maggiulli, Simona Alfano, Erminia Alviggi, Gemma Fabozzi, Danilo Cimadomo, Filippo Maria Ubaldi and Laura Rienzi; 7. Piezo: The add-on to standardize ICSI procedure Tetsunori Mukaida, Kenichiro Hiraoka, Hideaki Watanabe, Kiyotaka Kawai and Csaba Pribenszky; 8. Artificial oocyte activation after ICSI Thomas Ebner; 9. Health of children born after Intracytoplasmic Sperm Injections (ICSI) Shahad Sabti and Alastair G. Sutcliffe; 10. Examining the safety of Intracytoplasmic Sperm Injection (ICSI) using animal models Laura Hewitson; 11. Cellular and molecular events after ICSI in clinically relevant animal models Lauren Hamilton, Richard J. Oko and Peter Sutovsky; 12. Micromanipulation, microinjection microscopes and systems for ICSI Steven D. Fleming; 13. Automation techniques and systems for ICSI Changsheng Dai, Zhuoran Zhang, Guanqiao Shan and Yu Sun; 14. Germline nuclear transfer technology to overcome mitochondrial diseases and female infertility Mao-Xing Tang, Annekatrien Boel, Paul Couke and Björn Heindryckx; 15. Nuclear transfer technology and its use in reproductive medicine Pasqualino Loi, Marta Czernik, Luca Palazzese, Pier Augusto Scapolo, Helena Fulka and Josef Fulka Jr; 16. The prospects of infertility treatment using 'artificial' eggs Katsuhiko Hayashi; Index.

Read more less

Book SynopsisNon-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of tTrade ReviewIn its first edition, Pathology for Toxicologists edited by Dr Elizabeth McInnes is a much welcomed addition to the basic literature bridging the 2 complementary sciences of pathology and toxicology, specifically within the context of drug, chemical, or device industries. Aimed at the wide spectrum of study personnel supporting investigational and routine toxicity studies, this book provides a broad yet succinct coverage of the bases underlying the generation and interpretation of pathology data and enables a better use, comprehension, and integration of these data into toxicology reports. In its paperback presentation (provided for this review), the book is illustrated and has a good print quality, is concise, portable, and thoroughly referenced. The 6 contributing authors are all adequately qualified and have hands-on experience on the topics they covered; the editor herself contributed with 4 chapters. The book structure is organized into 8 chapters and include an introduction to pathology techniques, recording pathology data, general pathology and the terminology of basic pathology, common spontaneous and background lesions in laboratory animals, target organ pathology, clinical pathology, adversity from the pathologist’s perspective, and limitations of pathology and animal models.Each chapter begins with a learning objectives section and ends with a comprehensive list of references; a chapter-by-chapter analysis is included below. The book also includes a glossary (always helpful when dealing with pathology terms and acronyms)and an index. In short, this book is a bridging reference between toxicology and pathology, broadly covering the bases of laboratory animal pathology generation, interpretation, and communication, and it should prove useful not only for early career as well as for practicing toxicologists. (International Journal of Toxicology 36:5) ‘The book succinctly covers the general underpinnings of pathology data generation and interpretation, with the honorable goal of facilitating the use, communication, understanding, and integration of pathology data into toxicology reports …Six highly qualified authors contributed with 8 chapters (4 of which were authored by the editor), spanning various themes in pathology data generation and interpretation, including an introduction to pathology techniques, recording pathology data, general pathology and the terminology of basic pathology, common spontaneous and background lesions in laboratory animals, target organ pathology, clinical pathology, adversity from the pathologist’s perspective, and limitations of pathology and animal models … At the beginning of each chapter, a learning objectives box frames the most important concepts to be attained and, at its conclusion, a comprehensive list of references points the reader to additional information. The book is complete with an index and a glossary (a must-have when working with pathology terminology and acronyms). This textbook is a bridging reference covering the general bases of pathology data generation, interpretation, and communication that early career and practicing toxicologists will find useful.’ (Journal of Toxicologic Pathology, November 2017) 'Pathology for Toxicologists is highly recommended not only for toxicologist, but also for pharmaceutical research, discovery, and development scientists; young anatomic and clinical toxicologic pathologists; academic and diagnostic pathologists; and anatomic and clinical pathology graduate students and residents. Its use will successfully facilitate the interface between toxicologist and toxicologic pathologists. Its perusal by pharmaceutical research and discovery scientists will facilitate their understanding of the technical constraints and regulatory requirements that face toxicologic pathologists and toxicologic pathology laboratories. Its perusal by young anatomic and clinical toxicologic pathologists upon entry into toxicologic pathology will quickly bring them up-to-speed on the complexity of the regulations and constraints under which they will be working. Perusal of the book by toxicologists and study personnel will provide them an insight into the toxicologic pathology world, improving their interfaces and collaborations and facilitating decisions about pathology.' (Veterinary Clinical Pathology, November 2017)Table of ContentsList of Contributors xi Preface xiii 1 An Introduction to Pathology Techniques 1Elizabeth McInnes 1.1 Animal Considerations 2 1.2 Necropsy 2 1.3 Lung Inflation with Fixative 5 1.4 Fixation 5 1.5 Making Glass Slides 6 1.5.1 Trimming 6 1.5.2 Tissue Processing 9 1.5.3 Embedding 9 1.5.4 Microtoming 9 1.5.5 Staining 9 1.5.6 Quality Control 11 1.6 Special Histochemical Stains 12 1.7 Decalcification 13 1.8 Immunohistochemistry 13 1.9 Tissue Crossreactivity Studies 15 1.10 Electron Microscopy 15 1.11 In Situ Hybridisation 16 1.12 Laser Capture Microscopy 16 1.13 Confocal Microscopy 16 1.14 Image Analysis 17 1.15 Digital Imaging 17 1.16 Spermatocyte Analysis 17 1.17 Good Laboratory Practice 17 1.18 Inhalation Studies 18 1.19 Continuous]Infusion Studies 18 1.20 Carcinogenicity 19 1.21 Biologicals 19 1.22 The Pathology Report 20 1.23 Conclusion 20 References 20 2 Recording Pathology Data 23Cheryl L. Scudamore 2.1 What is a Pathology Finding? 24 2.2 Standardisation of Pathology Findings 24 2.2.1 Semiquantitative Analysis 24 2.2.2 Nomenclature/Controlled Terminology 26 2.2.3 Ontological Approach 28 2.3 ‘Inconsistencies’ in Pathology Recording 28 2.3.1 Diagnostic Drift 28 2.3.2 Thresholds 28 2.3.3 Lumping versus Splitting 29 2.4 Blind Review 30 2.5 Historical Control Data: Pros and Cons 30 2.6 The Use of Peer Review in Pathology 32 References 32 3 General Pathology and the Terminology of Basic Pathology 35Elizabeth McInnes 3.1 Cellular Responses to Insults 35 3.2 Inflammation 41 3.3 Circulatory Disturbances 46 3.4 Disorders of Tissue Growth 52 3.5 Tissue Repair and Healing 53 3.6 Neoplasia 54 3.7 Immune System 55 References 57 4 Common Spontaneous and Background Lesions in Laboratory Animals 59Elizabeth McInnes 4.1 Rats 62 4.2 Mice 63 4.3 Dogs 66 4.4 Minipigs 66 4.5 Non]Human Primates 67 4.6 Rabbits 67 4.7 Experimental Procedures 67 4.8 Causes of Death in Rats and Mice 67 4.9 Conclusion 68 References 69 5 Target Organ Pathology 72Elizabeth McInnes 5.1 Skin 72 5.2 Eye 76 5.3 Gastrointestinal Tract 78 5.4 Liver 83 5.5 Respiratory System 85 5.6 Urinary System 89 5.7 Lymphoreticular System 94 5.8 Musculoskeletal System 95 5.9 Cardiovascular System 97 5.10 Endocrine System 99 5.11 Reproductive System 102 5.12 Central and Peripheral Nervous System 104 5.13 Ear 106 References 106 6 Clinical Pathology 112Barbara von Beust 6.1 Clinical Pathology in Study Phases and Good Laboratory Practice 112 6.1.1 Preanalytic Phase: Study Plan 113 6.1.2 Analytic Phase: Data Generation 114 6.1.3 Postanalytic Phase: Data Interpretation and Reporting 114 6.1.4 Good Laboratory Practice 114 6.2 What is Measured in Clinical Pathology? 115 6.2.1 Interference by Haemolysis, Lipaemia and Icterus 116 6.3 Haematology 117 6.3.1 Manual and Automated Techniques in Haematology 118 6.3.2 Haematocrit and Red Blood Cell Mass 119 6.3.3 Blood Cells 120 6.3.4 The Standard Haematology Profile 124 6.3.5 Bone Marrow 125 6.4 Coagulation 125 6.4.1 Standard Coagulation Profile 126 6.4.2 Prothrombin Time 127 6.4.3 Activated Partial Thromboplastin Time 127 6.4.4 Fibrinogen 127 6.5 Clinical Chemistry 127 6.5.1 Metabolites 127 6.5.2 Enzymes 129 6.5.3 Electrolytes and Minerals 129 6.5.4 Standard Chemistry Profiles 130 6.6 Urinalysis 131 6.7 Acute]Phase Proteins 131 6.8 The Biomarker Concept 132 6.9 Reference Intervals 133 6.10 Instrumentation, Validation and Quality Control 133 6.11 Data Analysis and Interpretation 134 6.12 Reporting 135 6.13 Food Consumption and Body Weight (Gain) 136 6.14 Organ Weights 136 6.15 Examples of Typical Clinical Pathology Profile Changes in Toxicologic Clinical Pathology 136 6.15.1 Reduced Red Blood Cell Mass due to Chronic Disease 138 6.15.2 Stress Response 139 6.15.3 Reduced Red Blood Cell Mass due to Excessive Blood Sampling 139 6.15.4 Common Artefacts 139 6.16 Microsampling 140 6.17 Conclusion 141 Acknowledgments 141 References 141 7 Adversity: A Pathologist’s Perspective 145Bhanu Singh 7.1 LOAEL, NOEL and NOAEL: Definition 146 7.2 Adversity 147 7.3 Determining Adversity using Pathology Findings: Factors to Consider 149 7.3.1 Severity 149 7.3.2 Functional Effect 1507.3.3 Primary versus Secondary Effects 151 7.3.4 Physiological Adaptability 152 7.3.5 Reversibility of the Lesion 152 7.3.6 Pharmacological Effect 153 7.4 Communicating NOAEL in Toxicity Studies 153 7.5 Conclusion 154 References 154 8 Limitations of Pathology and Animal Models 157Natasha Neef 8.1 Limitations of In Vivo Animal Models 157 8.1.1 Traditional Laboratory Species Used as General Toxicology Models 157 8.1.2 The Test Article May Not have Sufficient Pharmacological Activity in Routine Toxicology Species 158 8.1.3 The Model May Not Identify Hazards Related to Causation or Exacerbation of Pathology that is Unique to Humans or Undetectable in Animals 159 8.1.4 The Model May Not Identify Hazards with Low Incidence/Low Severity 159 8.1.5 Potential for Misinterpretation of Reversibility/Recovery for Low]Incidence Findings 160 8.1.6 Potential for Over] or Underestimation of the Relationship to Test Article of Findings that have High Spontaneous Incidence in Laboratory Species, but are Relatively Rare in Humans 160 8.1.7 Exclusive Use of Young, Healthy Animals Kept in Ideal Conditions Gives Limited Predictivity for Aged/Diseased Human Populations 161 8.2 Efficacy/Disease Models as Toxicology Models 162 8.3 Limitations of Efficacy/Disease Models as Toxicology Models 164 8.3.1 Lack of Validation as Safety/Toxicology Models 164 8.3.2 Disease Models Rarely Have All the Elements of the Equivalent Human Disease 165 8.3.3 Limited Sensitivity Produced by Increased Interanimal Variability amongst Diseased Animals and/or Low Animal Numbers 165 8.3.4 Lack of Historical Data 166 8.3.5 Risk Associated with Nonregulated Laboratory Conditions 166 8.4 Limitations of Pathology within In Vivo Toxicology Models 167 8.4.1 Anatomic Pathology Evaluation Will Not Identify Hazards with No Morphological Correlates 167 8.4.2 Limitations of Pathology when Evaluating Moribund Animals or Animals Found Dead on Study 168 8.4.3 Limitations of Anatomic and/or Clinical Pathology End Points within other Types of In Vivo Preclinical Safety Study 168 8.4.4 Limitations of Histopathology Related to Sampling Error 169 8.4.5 Limitations of Quantitative Anatomic Pathology 170 8.4.6 Limitations of Pathology Related to Subjectivity and Pathologist Error 173 8.4.7 Anatomic Pathology Error/Missed Findings 173 8.4.8 Subjectivity and Pathologist Variability 175 8.5 Managing Risk Associated with Subjectivity and the Potential for Pathologist Error 176 8.5.1 Choice of Study Pathologist 176 8.5.2 Peer Review 176 8.5.3 Review of the Anatomic Pathology Data 177 8.5.4 Review of Anatomic Pathology Data Interpretation 177 References 179 Glossary 184 Index 187

Read more less

Book SynopsisBiomarkers in Heart Disease is the first title in the AHA Clinical Series and is aimed at meeting the needs of clinicians, providing cardiologists, internists, emergency physicians, laboratorians, and other healthcare providers with a clear understanding of the role of biomarkers in contemporary cardiovascular medicine.Trade Review“A vital contribution to a high-interest and emerging field, this comprehensive but concise discussion of the role of biomarkers in contemporary cardiovascular medicine focuses both on indications for biomarkers in current use as well as on new biomarkers. It is an essential read for anyone interested in the use of biomarkers in clinical practice. The quality and content of the book is excellent. It is a valuable resource for cardiovascular physicians, midlevel providers, or students in a rapidly changing field of cardiovascular medicine.” Doodys ReviewsTable of ContentsPart I Biomarkers for the Evaluation of Patients with Ischemic Heart Disease. 1 Protocols for Diagnosing Myocardial Infarction. 2 Troponin and Other Markers of Necrosis for Risk Stratification in Patients with Acute Coronary Syndromes. 3 Challenges Interpreting Cardiac Troponin Values. 4 Natriuretic Peptides and Inflammatory Markers for Risk Stratification in Patients with Ischemic Heart Disease. 5 Novel Markers in Patients with Suspected ACS. Part II Biomarkers for Evaluation of Patients with Heart Failure. 6 Use of Natriuretic Peptides in the Diagnosis of Heart Failure. 7 Biomarkers for Risk Stratification in Patients with Heart Failure. 8 Natriuretic Peptides for Disease Monitoring in Patients with Chronic Heart Failure. Part III Biomarkers for Screening in the Ambulatory Populations. 9 CRP. 10 Newer Markers for Population Screening. Part IV A Look to the Future. 11 Moving Toward Personalized Medicine.

Read more less

Book SynopsisIn their preface, the authors highlight the great social and medical importance of hearing loss in the elderly, an ever-increasing prob lem. It is, therefore, most appropriate that a monograph, devoted to research in this field, features as an addition to the Bloomsbury Series in Clinical Science. Written by two leading authorities, the book reviews the past and present literature, details the clinical aspects and considers the electrophysiological and histopatho logical issues basic to the overall problem. It continues the high standard and excellence fostered by previous issues in the Series. London, August 1990 Jack Tinker Preface The number of very old people in the community is steadily increasing so the hearing loss that many of them endure has become a disorder of social and medical importance. Only by a greater scientific knowledge of old age deafness can there be any posTable of Contents1 Review of Literature.- Up to the Early Twentieth Century.- Recent Times.- Localization of the Disturbance.- Central.- Peripheral.- Aetiological Basis for the Disturbance.- Role of Exogenous Factors.- Summary.- Localization.- Aetiological Basis.- 2 Clinical Diagnosis and Audiometric Studies.- Clinical Dignosis.- History.- Examination of the Ear.- Clinical Speech Tests.- Tuning Fork Methods.- Audiogram.- Tympanometry.- X-Rays.- Electrophysiology.- Calorics and Electronystagmography.- Disorders of the External Ear.- Disorders of the Middle Ear.- Disorders of the Inner Ear.- Presbyacusis.- Noise Induced Hearing Loss.- Ototoxicity.- Bone Lesions of the Otic Capsule.- Acoustic Neuroma.- Tinnitus.- Audiometric Studies.- Personal Investigations.- Hearing Levels in a Large Group of Elderly People.- Comparison of Hearing Levels in Different Medical and Environmental Conditions.- 3 Electrophysiology.- (In collaboration with S.M. Mason).- Extratympanic Electrocochleography.- Detailed Investigation of ABR; Preliminary Investigation of ECochG.- Procedure.- Results.- Discussion.- Summary.- Simultaneous Recordings of ABR and ECochG; Detailed Investigation of ECochG Components.- Procedure.- Results.- Discussion.- Conclusions.- Summary.- Stimulus Rate Effects.- Procedure.- Results.- Discussion.- 4 Histopathological Changes.- Perfusion-Fixation and Slicing of Inner Ear.- Staining of Surface Preparations.- Preliminary Survey of Morphological Changes in Elderly Cochleas.- Procedure.- Results.- Discussion.- Quantitative Analysis of Hair Cell Changes.- Procedure.- Results.- Discussion.- Summary of Histopathological Changes.- 5 Summing-up.

Read more less

Book SynopsisWith extensively revised content and an expanded contributor list of experts, Fenoglio-Preiser’s Gastrointestinal Pathology, Fourth Edition keeps you current in this fast-changing field. This highly regarded text remains your go-to reference on gastrointestinal pathology, with coverage of everything from anatomy, physiology, and histology to the full spectrum of congenital disorders, structural alterations, diseases, injuries, and other entities. This comprehensive reference is an ideal resource for pathologists, radiologists, gastroenterologists, and others interested in gastrointestinal diseases. Key Features: Contains extensively revised and updated content throughout, while maintaining the same practical, easy-to-use format as the previous edition. Covers benign and malignant gastrointestinal diseases not often included in other texts, as well as in-depth discussions of pathophysiologic processes and molecular mechanisms wherever possible.Trade Review'a reliable and authoritative reference for practicing pathologists and their trainees'' well written and artfully illustrated''photographs are one of its strong features, and the drawings are just wonderful''its unique emphasis on linking the basic sciences and clinic practice''ideal book for trying to keep up with the modern developments of molecular biology as it is used in clinical medicine''ideal for pathologists and clinicians teaching in multidisciplinary curricula of the 21st century medical schools and designing modern residency training programs''the differential diagnosis tables and the conceptual diagrammatic drawings distill a lot of knowledge and experience'Weighted Numerical Score: 90 - 4 Stars!-Doodys Publishers' Club, May 12, 2017

Read more less

Book Synopsis

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisIn this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and-for the first time-on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. Comprehensive and cutting-edge, Cardiac Markers, Second Edition offers physicians a complete guide to the use of cardiac markers in clinical practice and clinical laboratorians a close-up view of the new markers now becoming standard.Trade Review"addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the book-shelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine "...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal "This comprehensive book not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratories with detailed information on the new markers which are now becoming standard." - Clinical Laboratory International "...highly recommended as a reference resource for cardiologists, internists, emergency medicine physicians, and laboratory medicine physicians who have specific questions regarding the many clinically relevant cardiac markers...will save the physician considerable time and effort in answering a specific question that he or she may have within this rapidly evolving field." - Texas Heart Institute Journal From reviews of the first edition... "...provides a concise and informative summary of a rapidly developing field and will be a useful addition to the bookshelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine "...a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical application...highly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review JournalTable of ContentsPart I. Cardiac Markers in Clinical Practice Early Detection of Myocardial Necrosis in the Emergency Setting and Utility of Serum Biomarkers in Chest Pain Unit Protocols Andra L. Blomkalns and W. Brian Gibler Management of Acute Coronary Syndromes Constantine N. Aroney and James A. de Lemos Evolution of Cardiac Markers in Clinical Trials Alexander S. Ro and Christopher R. deFilippi Assessing Reperfusion and Prognostic Infarct Sizing with Biochemical Markers: Practice and Promise Robert H. Christenson and Hassan M. E. Azzazy The Use of Cardiac Biomarkers to Detect Myocardial Damage Induced by Chemotherapeutic Agents Eugene H. Herman, Steven E. Lipshultz, and Victor J. Ferrans The Use of Biomarkers to Provide Diagnostic and Prognostic Information Following Cardiac Surgery Jesse E. Adams, III Part II. Clinical Use for Cardiac Troponins Cardiac Troponins: Exploiting the Diagnostic Potential of Disease-Induced Protein Modifications Ralf Labugger, D. Kent Arrell, and Jennifer E. Van Eyk Cardiac Troponin Testing in Renal Failure and Skeletal Muscle Disease Patients Fred S. Apple Cardiac-Specific Troponins Beyond Ischemic Heart Disease David Morrow Part III. Analytical Issues for Cardiac Markers Antibody Selection Strategies in Cardiac Troponin Assays Alexei Katrukha Interferences in Immunoassays for Cardiac Troponin Kiang-Teck J. Yeo and Daniel M. Hoefner Cardiac Marker Measurement by Point-of-Care Testing Paul O. Collinson Standardization of Cardiac Markers Mauro Panteghini Analytical Issues and the Evolution of Cutoff Concentrations for Cardiac Markers Alan H. B. Wu Part IV. Early Cardiac Markers of Myocardial Ischemia and Risk Stratification Rationale for the Early Clinical Application of Markers of Ischemia in Patients with Suspected Acute Coronary Syndromes Robert L. Jesse Ischemia-Modified Albumin, Free Fatty Acids, Whole Blood Choline, B-Type Natriuretic Peptide, Glycogen Phosphorylase BB, and Cardiac Troponin Alan H. B. Wu, Peter Crosby, Gary Fagan, Oliver Danne, Ulrich Frei, Martin Möckel, and Joseph Keffer C-Reactive Protein for Primary Risk Assessment Gavin J. Blake and Paul M. Ridker Prognostic Role of Plasma High-Sensitivity C-Reactive Protein Levels in Acute Coronary Syndromes Luigi M. Biasucci, Antonio Abbate, and Giovanna Liuzzo Preanalytic and Analytic Sources of Variations in C-Reactive Protein Measurement Thomas B. Ledue and Nader Rifai Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification Jan F. C. Glatz, Roy F. M. van der Putten, and Wim T. Hermens Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein in Patients with Coronary Artery Disease Paul Holvoet Part V. Cardiac Markers of Congestive Heart Failure Pathophysiology of Heart Failure Johannes Mair B-Type Natriuretic Peptide: Biochemistry and Measurement Jeffrey R. Dahlen B-Type Natriuretic Peptide in the Diagnoses and Management of Congestive Heart Failure Ramin Tabbibizar and Alan Maisel Monitoring Efficacy of Treatment with Brain Natriuretic Peptide Emil D. Missov and Leslie W. Miller N-Terminal Pro-B-Type Natriuretic Peptide Torbjørn Omland and Christian Hall Part VI. Role of Infectious Diseases and Genetics in Heart Disease Infectious Diseases in the Etiology of Atherosclerosis and Acute Coronary Syndromes: Focus on Chlamydia pneumoniae Martin Möckel Polymorphisms Related to Acute Coronary Syndromes and Heart Failure: Potential Targets for Pharmacogenomics Alan H. B.

Read more less

Book Synopsis

Read more less

Book SynopsisThis book is a unique surgical pathology grossing atlas, comprised of a collection of photos of various anatomic specimens frequently encountered in routine and frozen surgical pathology practice, including various organ systems. The photos in this atlas have been collected over many years of practicing surgical pathology in one of the largest medical centers in the world, and include emphasis on important anatomic landmarks and explanations on how to properly orient, section and sample anatomic specimens. The use of actual gross images allows readers to more readily apply the grossing tips to actual specimens that they encounter at the grossing bench. Each chapter is arranged by organ system and includes essential tips for grossing each specimen and sample dictations with all the essential elements that must be addressed for proper assessment of each organ specimen.Written by expert pathologists, Atlas of Surgical Pathology Grossing is an excellent resource for pathologists, medical and pathology assistant students, residents, both in surgery and pathology, and pathology assistants.Table of ContentsSkin.- Breast.- Head and Neck.- Gastrointestinal Tract.- Hepatobiliary and Pancreas.- Genitourinary.- Female Reproductive Tract.- Lung.- Bone and Soft Tissue.

Read more less

Book SynopsisThis book covers the complete field of head and neck pathology – from Abscess to Wegener`s Granulomatosis, Sinonasal. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.Trade Review“The purpose is to provide a systematic overview of head and neck pathology in an encyclopedic fashion and to supplement the medical literature with a reference work. … Although written primarily for general pathologists, this will also be useful for pathology residents and fellows in head and neck pathology. … this volume will find its place in the expanding arena of pathology books, as it is a valuable contribution to the field.” (Anamarija M. Perry, Doody’s Book Reviews, August, 2016)Table of ContentsAbscess, Parapharyngeal.- Abscess, Peritonsillar.- Abscess, Retropharyngeal.- Acinic Cell Carcinoma, Salivary Glands of.- Adenocarcinoma NOS, Salivary Glands of.- Adenocarcinoma,Ceruminous.- Adenoid Cystic carcinoma, Salivary Glands of.- Adenoma Pituitary, Ectopic Sinonasal.- Adenoma, Middle Ear of.- Adenosquamous Carcinoma, Larynx.- Adult Rhabdomyoma.- Aggressive Papillary Tumor, Middle Ear of.- Aspergillosis, Sinonasal.- Basal Cell Adenocarcinoma, Salivary Glands of.- Basal Cell Adenoma, Salivary Glands of.- Benign Inclusions, Lymph Nodes.- Branchial Cyst.- Canalicular Adenoma, Salivary Glands of.- Carcinoma Ex Pleomorphic Adenoma.- Carcinoma, Cylindrical Cell.- Carcinoma, Tonsillar.- Carcinosarcoma, Salivary Glands of.- Ceruminoma.- Cholesteatoma.- Cholesterol Granuloma, Middle Ear.- Chondrodermatitis Nodularis Chronica Helicis.- Chondroma, Larynx.- Chondromalacia, Idiopathic Pseudocystic, External Ear of.- Chondrosarcoma, Larynx.- Chordoma.- Choristoma, Middle Ear of.- Clear Cell Carcinoma, Salivary Glands of.- Craniopharyngioma.- Cyst, Thornwald.- Cystadenocarcinoma, Salivary Glands of.- Cystadenoma, Salivary Glands of.- Cystic Hygroma.- Cystic Lymphoid Hyperplasia of AIDS, Salivary Glands of.- Ear and Temporal Bone.- Edema Reinke.- Encephalocoele.- Endolymphatic Sac Tumor.- Epithelial-Myoepithelial Carcinoma, Salivary Glands of.- Extranodal Marginal Zone B Cell Lymphoma, Salivary Glands of.- Germ Cell Tumors,Sinonasal.- Glossectomy.- Haemangioma, Salivary Glands of.-Haemangiopericytoma, Sinonasal-type.- Hamartoma, Respiratory Epithelial Adenomatoid.- Heterotopia, Salivary Glands of.- Infectious Mononucleosis, Tonsills.- Keratosis Obturans, Auditory Canal of.- Küttner Tumor.- Labyrinthitis.- Laryngeal Granuloma.- Laryngectomy.- Laryngitis, Acute.- Laryngitis, Allergic.- Laryngitis, Chronic.- Laryngitis, Reflux.- Laryngocoele and laryngeal cysts.- Laryngomalacia.- Larynx and Hypopharynx.- Lipomatosis Coli.- Low-Grade Cribriform Cystadenocarcinoma, Salivary Glands of.- Lymphoepithelial Cyst, Salivary Glands of.- Mandibular Resection.- Mastoiditis.- Maxillectomy.- Meniere's Disease.- Meningioma, Middle Ear.- Metastatic Neoplasm of Unknown Primary, Neck.- Mucinous Adenocarcinoma, Salivary Glands of.- mucocele, middle ear of.- Mucocele, Paranasal Sinuses of.- Mucoepidermoid Carcinoma, Salivary Glands of.- Mucosal Malignant Melanoma, Sinonasal.- Mucous Retention Cyst, Salivary Glands of.- Myoepithelial Carcinoma, Salivary Glands of.- Myoepithelioma, Salivary Glands of.- Myxoma, Sinonasal.- Nasal Cavity, Paranasal Sinuses and Nasopharynx.- Nasal Glial Heterotopia.- Nasopharyngeal Adenocarcinoma, Papillary.- Nasopharyngeal Adenocarcinoma, Salivary Gland-Type.- Nasopharyngeal Angiofibroma.- Nasopharyngeal Carcinoma.- Neck.- Neck Dissection.- Necrotising Sialometaplasia.- Neuroectodermal Tumor of Infancy.- Neuroma, Acoustic.- NUT Midline Carcinoma.- Olfactory Neuroblastoma.- Oncocytic Carcinoma, Salivary Glands of.- Oncocytoma, Salivary Glands of.- Oral Cavity, Tongue and Oropharynx.- Otitis Externa.- Otitis Externa, Malignant.- Otitis Media, Acute.- Otitis Media, Chronic.- Otitis Media, Secretory Otosclerosis.- Papillary Cystadenoma Lymphomatosum, Parotid Gland of.- Paraganglioma, Malignant.- Pleomorphic Adenoma.- Pleomorphic Adenoma, Metastasizing.- Polymorphous Low Grade Adenocarcinoma, Salivary Glands of.- Polyp, Allergic Sinonasal.- Polyp,Antrochoanal.- Polyp, Ottic.- Polyp, Sinonasal.- Polyp, Sinonasal with Stromal Atypia.- Polyposis, Nasal, in Immotile Cilia Syndrome.- Rathke`s Cleft Cyst.- Relapsing Polychondritis, External Ear.- Rhinitis, Acute.- Rhinitis, Allergic.- Rhinitis, Chronic Atrophic.- Rhinitis, Chronic Hypertrophic.- Rhinitis, Chronic Non-Specific.- Salivary Duct Carcinoma.- Salivary Duct Cyst.- Salivary Gland Anlage Tumor.- Salivary Glands.- Salivary Polycystic Dysgenetic Disease.- Sclerosing Polycystic Adenosis, Salivary Glands of.- Sebaceous Adenoma, Salivary Glands of.- Sebaceous Lymphadenoma, Salivary Glands of.- Secondary Tumors, Salivary Gland.- Sialadenitis, Acute.- Sialadenitis, Chronic.- Sialadenitis, Lymphoepithelial.- Sialoblastoma.- Sialolithiasis.- Sininasal Adenocarcinoma.- Sinonasal Papilloma, Exophytic.- Sinonasal Papilloma, Inverted.- Sinonasal Papilloma, Oncocytic.- Sinonasal Undifferentiated Carcinoma.- Sinus Histiocytosis with Massive Lymphadenopathy, xtranodal.- Sinus, Preauricular.- Sinusitis, Acute.- Sinusitis, Allergic Fungal.- Sinusitis, Chronic.- Sjögren´s syndrome.- Solid and Cribriform Adenocarcinoma, Salivary Glands of.- Spindle Cell Carcinoma, Larynx.- Squamous Cell Carcinoma, Acantholytic.- Squamous Cell Carcinoma, Basaloid.- Squamous Cell Carcinoma, Exophytic.- Squamous Cell Carcinoma, Head and Neck.- Squamous Cell Carcinoma, Papillary.- Squamous Intraepithelial Lesions, Ljubljana Classification.- Squamous Papilloma, Upper Respiratory Tract of.- Stenosis, Subglottic Surgical Ciliated Cyst, of Maxilla.- Syringocystadenoma Papilliferum, Ceruminal Glands of.- Teratoma, Congenital Nasopharyngeal.- Thyroglossal Duct Cyst.- Tonsillitis, Acute Tonsillitis, Chronic.- Tympanosclerosis.- Verruccous Carcinoma, Larynx.- Vocal Cord Nodule.- Vocal Cord Polyp.- Waldeyer's Ring.- Wegener's Granulomatosis, Sinonasal.

Read more less

Book SynopsisThis superbly illustrated book is the most comprehensive available guide to adnexal neoplasms of the skin. More than 70 entities are described in individual chapters that follow a uniform structure: historical review, clinical features, histopathology, histogenesis, immunohistochemistry, molecular anomalies, and treatment. Readers will find state of the art knowledge on all aspects, including the cytogenetic and chromosomal abnormalities associated with each neoplasm. Without exception, the illustrations are high-quality, full-color, original digital pictures. The histopathology images are taken from perfectly cut and stained sections and the immunohistochemistry illustrations are of an unrivalled quality among textbooks of dermatology and dermatopathology. A complete list of references from original description to the present day is also supplied for each neoplasm. Cutaneous adnexal neoplasms are a large and heterogeneous group of benign and malignant lesions. This book will assist the reader in early and correct recognition, which is essential for appropriate choice of treatment and prognostic assessment.Table of ContentsDedication.- Acknowledgements.- Preface.- I Neoplasms With Eccrine And Apocrine Differentiation.- 1 Apocrine And Eccrine Units.- 2 General Principles For The Histopathological Diagnosis Of Neoplasms With Eccrine And Apocrine Differentiation. Classification And Histopathologic Criteria For Eccrine And Apocrine Differentiation.- 3 Hidrocystomas.- 4 Eccrine And Apocrine Nevi.- 5 Porokeratotic Adnexal Ostial Nevus.- 6 Supernumerary Nipple.- 7 Syringocystadenoma Papilliferum.- 8 Nipple Adenoma.- 9 Hidradenoma Papilliferum.- 10 Apocrine Hidradenoma.- 11 Mixed Tumors of the Skin.- 12 Tubular Adenoma.- 13 Cutaneous Fibroadenoma.- 14 Cylindroma and Spiradenoma.- 15 Syringoma.- 16 Poromas.- 17 Tubular Carcinoma.- 18 Papillary Carcinoma.- 19 Syringocystadenocarcinoma Papilliferum.- 20 Apocrine Hidradenocarcinoma.- 21 Hidradenocarcinoma Papilliferum.- 22 Malignant Mixed Tumor Of The Skin.- 23 Cylindrocarcinoma And Spiradenocarcinoma.- 24 Syringoid Carcinoma.- 25 Porocarcinoma.- 26 Microcystic Adnexal Carcinoma.- 27 Adenoid Cystic Carcinoma.- 28 Cribriform Carcinoma.- 29 Mucinous Carcinoma.- 30 Primary Cutaneous Signet-Ring Cell Carcinoma .- 31 Secretory Carcinoma .- 32 Polymorphous Sweat Gland Carcinoma.- 33 Extramammary Paget’s Disease.- 34 Basal Cell Carcinoma With Ductal Differentiation.- 35 Neoplasms Of The Mammary-Like Glands Of The Anogenital Region.- II Neoplasms With Follicular Differentiation.- 36 Embriology, Histology And Physiology Of The Hair Follicle.- 37 Histopathologic Criteria For Follicular Differentiation.- 38 Classification Of The Proliferations With Follicular Differentiation.- 39 Nevus Comedonicus.- 40 Basaloid Follicular Hamartoma.- 41 Trichofolliculoma.- 42 Fibrous Papule.- 43 Trichoadenoma.- 44 Fibrofolliculoma And Trichodiscoma.- 45 Infundibular Cyst.- 46 Tricholemmal Cyst.- 47 Dilated Pore of Winer.- 48 Follicular Induction.- 49 Inverted Follicular Keratosis and Tricholemmoma.- 50 Panfolliculoma.- 51 Trichoblastoma.- 52 Pilomatricoma.- 53 Pilar Sheath Acanthoma.- 54 Tumor Of The Follicular Infundibulum.- 55 Proliferating Tricholemmal Tumor.- 56 Pilomatrixcarcinoma.- 57 Basal Cell Carcinoma With Follicular Differentiation.- III Neoplasms With Sebaceous Differentiation.- 58 Embriology, Anatomy, Histology And Physiology Of The Sebaceous Glands.- 59 Histopathologic Criteria For Sebaceous Differentiation.- 60 Classification Of The Proliferations With Sebaceous Differentiation.- 61 Yuxta-Clavicular Beaded Lines.- 62 Ectopic Sebaceous Glands.- 63 Nevus of Jadassohn.- 64. Steatocystoma.- 65 Folliculo-Sebaceous Cystic Hamartoma.- 66 Sebaceous Hyperplasia And Rhinophyma.- 67 Sebaceous Induction.- 68 Sebaceous Adenoma And Sebaceoma.- 69 Seborrheic Keratosis With Sebaceous Differentiation.- 70 Reticulated Acanthoma With Sebaceous Differentiation.- 71 Basal Cell Carcinoma With Sebaceous Differentiation.- 72 Sebaceous Carcinoma.- IV Neoplasms Combining Several Types Of Differentiation.- 73 Neoplasms Combining Sebaceous, Apocrine And Follicular Differentiation.- V Inherited Syndromes With Adnexal Neoplasms.- 74 Inherited Syndromes With Cutaneous Adnexal Neoplasms.- Subject Index.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThis book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. Trade Review“The purpose is to provide organ system-based summaries of spontaneous pathology and common responses to xenobiotics. … used as a textbook or reference for students, as an informative resource for novices in the field, and as a reference for researchers in the immune toxicology field. It also can be educational for the lay public who are interested in learning immunopathology in xenobiotics or general basic immunology. … a terrific book that I will certainly integrate into my graduate teaching.” (Hongmin Ni, Doody's Book Reviews, November, 2017)Table of ContentsThymus.- Spleen.- Lymph node.- Mucosa-associated lymphoid tissues.- Immunopathology of the nervous system.- Immunopathology of the urinary system.- Immunopathology of the hepatobiliary system.- Immunopathology of the respiratory system.- Immunopathology of the cardiovascular system.- Immunopathology of the male reproductive tract.- Immunopathology of the female reproductive tract and mammary gland.- Immunopathology of the musculoskeletal system.- Immunopathology of the endocrine system.- Ocular Immunopathology.- Immunopathology of Drug and Toxin-related Skin Reactions.

Read more less

Book SynopsisThis book contains a compilation of high-yield, at-a-glance summaries in quick reference format for various topics that are frequently encountered by pathologists in the daily practice or on the boards. The focus is not organ-based histologic criteria, but rather everything else that goes into pathologic diagnoses but is difficult to keep committed to memory. The emphasis is on immunohistochemistry, special stains, grading systems, molecular markers, tumor syndromes, and helpful clinical references. Also included are morphologic summaries that encompass high-yield material cutting across all organ systems, such as an illustrated guide for microorganisms, tumor differentials, and an illustrated glossary of pathologic descriptors.The book has a unique format in that the information is presented primarily in tables and diagrams accompanied by brief and to-the-point explanatory text. The guiding principle was to boil the information down to the essentials but with just enough commentary to be accessible to a newcomer to pathology and to serve as a quick reference to a practicing pathologist. In the 7 years since its initial publication, there have been considerable advances in surgical pathology, particularly immunohistochemical stains, molecular diagnostics, and histologic grading schemes. In the second edition, the content has been thoroughly updated to incorporate these developments, while retaining the overall scope and concise format of the first edition. In addition, the reader will find summaries for many new topics as well as multiple new cartoon illustrations and diagrams. Table of ContentsImmunostains: Introduction.- Immunostains: Solid Tumors.- Immunostains: Hematopoietic System.- Predictive Markers.- Immunostains: Antibody Index/Solid Tumors.- Immunostains: Antibody Index/Hematopoietuc System.- Special Stains.- Grading (and Classification) Quick Reference: Solid Tumors.- Grading (and Classification) Quick Reference: Hematopoietic System.- Tumor Genetics and Cytogenetics: Solid Tumors.- Tumor Genetics and Cytogenetics: Hematopoietic System.- Tumor Syndromes.- Quick Clinical References for Pathologists.- Potpourri of Quick Morphologic References.- Quick Size References.- It looks like WHAT? An Illustrated Glossary of Histopathologic Descriptors.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThis is the most up-to-date book yet published on pathology of the head and neck. Its contents have been divided into ten chapters, devoted to the spectrum of precursor and neoplastic lesions of the squamous epithelium; the nasal cavities and paranasal sinuses; oral cavity, maxillofacial skeleton and teeth; salivary glands, nasopharynx and Waldeyer`s ring; larynx and hypopharynx, ear and temporal bone; neck and neck dissection, as well as eye and ocular adnexa.Table of ContentsBenign and Potentially Malignant Lesions of the Squamous Epithelium and Squamous Cell Carcinoma.- Nasal Cavity and Paranasal Sinuses.- Oral Cavity.- Maxillofacial Skeleton and Teeth.- Major and Minor Salivary Glands.- Nasopharynx and Waldeyer’s Ring.- Larynx and Hypopharynx.- Ear and Temporal Bone.- Cysts and Unknown Primary and Secondary Tumours of the Neck, and Neck Dissection.- Eye and Ocular Adnexa.

Read more less

Table of ContentsMorphology and Pathogenesis of Glomerulopathy in Cadaver Kidney Allografts Treated with Antilymphocyte Globulin (Clinical, Light, Electron and Immunofluorescent Optic Examinations).- Some Aspects of Sarcoidosis.- The Interepithelial Lymphocytes of the Intestinum. Morphological Observations and Immunological Aspects of Intestinal Enteropathy.- Multiple Deep Fungus Infections: Personal Observations and a Critical Review of the World Literature.- Author Index.

Read more less

Table of ContentsSpontaneous Chimerism in Mammals: A Critical Review.- Quantitative Autoradiography: Statistical Study of the Variance, Error and Sensitivity of the Labeling Index (Thymidine-H3 and DNA Synthesis).- Renal Siderosis. Morphology, Etiology, Pathogenesis and Differential Diagnosis. With Special Reference to Traumatic Hemolytic Anemia.- Morphogenesis of Anencephaly and Related Malformations.- The Chediak-Higashi Syndrome: A Comparative Review.- Author Index.

Read more less

Book SynopsisBei diesem Buch handelt es sich um eine Zusammenstellung zahlreicher Artikelund Beitr{ge, die 1989 in diversen neurologischen Fachzeitschriften und B}chern zum Thema "Hydrozephalus" erschienen sind.Table of Contents(1) Magnetic Resonance Imaging of Silastic-Induced Canine Hydrocephalus.- (2) Age-dependent Changes of Cerebral Ventricular Size. Part I: Review of intracranial fluid collections.- (3) Porencephaly and Hydranencephaly: A neuropathological study of four autopsy cases.- (4) Immunohistochemical Evaluation of Neuronal Maturation in Untreated Fetal Hydrocephalus.- (5) Quantitative Fatty Acid Composition of Cerebrospinal Fluid in Hydrocephalic Children with Remarkable Ventricular Dilatation.- (6) Effects of Hydrocephalus and Surgical Decompression on Cortical Norepinephrine Levels in Neonatal Cats.- (7) A Technique for Placing Ventriculoperitoneal Shunts in a Neonatal Model of Hydrocephalus.- (8) Prenatal CSF Shunt Procedure for Fetal Hydrocephalus: Animal experimental model—Pressure dynamics of intrauterine hydrocephalus and Fetus Ventriculo-Mater Peritoneal Shunt (FV-MP shunt)—.- (9) Therapeutic Criteria in Hydrocephalic Children.- (1) Hydrocephalus-Induced Changes in the Composition of Cerebrospinal Fluid.- (2) The Importance of “Accessory” Outflow Pathways in Hydrocephalus after Experimental Subarachnoid Hemorrhage.- (3) Measurement of the CSF Velocity Using Cine-mode MRI.- (4) MRI of CSF Flow in Normal Pressure Hydrocephalus.- (5) Regional Cerebral Blood Flow after V-P Shunt in Hydrocephalic Children.- (6) Cerebral Perfusion Pressure and Nett Cerebral Mean Transit Time in Childhood Hydrocephalus.- (7) Cerebral Hemodynamics and Functional Prognosis in Hydrocephalus.- (8) Pulse Amplitude and Volume-pressure Relationships in Experimental Hydrocephalus.- (9) A Case with Chronic Renal Hemodialysis and Intracranial Hypertension: A study on CSF dynamics.- (10) The Role of Cerebrospinal Compensatory Parameters in the Estimation of Implanted Shunt System in Patients with Communicating Hydrocephalus: Preliminary report.- (11) The Use of Intraventricular Resorption Test (IVT) in the Management of Hydrocephalic Children.- (12) Relationship Between Compliance and Resistance to Out-flow of CSF in Adult Hydrocephalus.- (13) Progressive Unilateral Hydrocephalus in Adults.- (1) Identical Twins with Idiopathic External Hydrocephalus.- (2) Association of von Recklinghausen’s Neurofibromatosis and Aqueduct Stenosis.- (3) An Apparently New Autosomal Recessive Syndrome with Facial Dysmorphism, Macrocephaly, Myopia and Dandy-Walker Malformation.- (4) Cerebral Ventricular Enlargement Relates to Neuropsychological Measures in Unselected AIDS Patients.- (5) Bobble-head Doll Syndrome Associated with the Iii Ventricular Cyst: Three cases in children 7 years after CVP or CVA shunting.- (1) MR-Gated Intracranial CSF Dynamics: Evaluation of CSF pulsatile flow.- (2) Variation of Lateral Ventricular Volume During the Cardiac Cycle Observed by MR Imaging.- (3) MRI as the Primary Diagnostic Instrument in Normal Pressure Hydrocephalus?.- (4) Antenatal Detection of Congenital Malformations by Routine Ultrasonography.- (5) Pre-natal Intracranial Haemorrhage.- (6) Morphological Evaluation of Fetus CNS and Its Related Anomalies: The advantages and limitations of prenatal diagnosis by means of MRI·US·CT.- (1) Lumboperitoneal Shunt for the Treatment of Postoperative Persistent Collection of Subcutaneous Cerebrospinal Fluid (Pseudomeningocele).- (2) Percutaneous Insertion of CSF Ventriculoatrial Shunts: A new technique—Technical note.- (3) A New, Curved Catheter for Ventriculoperitoneal Shunting: Technical note.- (4) The Shunt Flow in Programmable Pressure Valve.- (5) Scintigraphic Study of CSF Shunts’ Patency.- (6) Thermosensitive Determination of Patency in Lumboperitoneal Shunts: Technical note.- (7) Isotope Transport Studies and Shunt Pressure Measurements as a Guide to Shunt Function.- (8) Analysis of CSF Flow Through LP Shunt During Change of Posture.- (9) Cerebrospinal Fluid Shunts: Flow measurements with MR Imaging.- (10) MR Visualization of CSF Flow Through a Ventriculo-cisternostomy.- (11) Hydrocephalus in Premature Infants: Characteristics and therapeutic problems.- (12) Reversible Porencephaly Associated with Shunt Malfunction.- (13) Low Pressure Hydrocephalus after Shunt Revision: Postrevisional low pressure hydrocephalus.- (14) The Incidence and Management of the Slit Ventricle Syndrome.- (15) The Complication of Ascites in Hydrocephalus.- (16) Craniofacial Morphology in Untreated and Shunt-treated Hydrocephalic Children.- (17) New Clinical Phase in Intrauterine Diagnosis and Therapeutic Modalities of CNS Anomalies.- (18) Hydrocephalus: Antenatal detection and neonatal neurosurgical management.- (19) Antenatal Detection of Developing Nervous System Abnormalities and Perinatal Surgical Management.- (1) Age-Related Changes of Cerebral Ventricular Size. Part II: Normalization of ventricular size following shunting.- (2) The Changing Panorama of Infantile Hydrocephalus and Cerebral Palsy Over Forty Years: A Swedish survey.- (1) Evaluation of Adverse Criteria for Spina Bifida Cystica from a Prognostic Point of View.- (2) Long-term Follow-up Results of Infants with Myelomeningocele.- (3) Symptomatic Chiari Malformation Associated with Cranium Bifidum.- (4) Coexistence of Dandy-Walker Syndrome and Down’s Syndrome.- (5) A Case of Holoprosencephaly Associated with Dandy-Walker Cyst: A long-term follow-up.- (6) Holoprosencephaly Associated with Dandy-Walker Syndrome: Report of two autopsy cases.- (7) A Case of Holoprosencephaly with a Large Parietal Meningocele-like Cyst.- (8) Holoprosencephaly, Ear Abnormalities, Congenital Heart Defect, and Microphallus in a Patient with 11q-Mosaicism.- (9) Congenital Unilateral Hydrocephalus.- (10) Congenital Toxoplasmosis in Identical Twins.- (11) Hydrocephalus in Achondroplasia: The possible role of intracranial venous hypertension.- (12) Hydrocephalus in Crouzon’s Syndrome.- (13) Cloverleaf Skull Syndrome with Occipital Bone Cristae.- (14) MR Imaging of Aqueductal Stenosis Due to Tectal Region Tumors.- (15) A Case of Primary Malignant Lymphoma of the Brain Associated with Acute Hydrocephalus.- (16) Management of Posthaemorrhagic Hydrocephalus with a Subcutaneous Ventricular Catheter Reservoir in Premature Infants.- (17) Factors Associated with Hydrocephalus after Subarachnoid Hemorrhage: A report of the cooperative aneurysm study.- (18) Cerebrospinal Fluid Pressure in Pyrogenic Meningitis.- (19) Risk Factors for the Syndrome of Ventricular Enlargement with Gait Apraxia (Idiopathic Normal Pressure Hydrocephalus): A case-control study.- (20) Transcranial Doppler Sonographic Identification of a Subgroup of Patients with Normal Pressure Hydrocephalus with Coexistent Vascular Disease and Treatment Failure.- (21) Hemodynamic and Metabolic Studies of Patients with Normal Pressure Hydrocephalus Using Positron Emission Tomography.- (22) Regional Cerebral Blood Flow and Oxygen Metabolism in Normal Pressure Hydrocephalus after Subarachnoid Hemorrhage.- (23) Computed Tomography of the Brain in the Diagnosis of and Prognosis in Normal Pressure Hydrocephalus.- (24) Ultrastructure of the Human Posttraumatic Syrinx.- (25) Hydrodynamic Study of Syringomyelia by Mri and Intraoperative Ultrasonography.- (26) Syringomyelia Extending to the Basal Ganglia: Case report.- (27) Multicystic Syringomyelia Treated with a Single, Non-valved Syringoperitoneal Shunt: Fast and near-complete MRI normalization.- (28) Cordectomy for Syringobulbo-Myelia with Sleep Apnea Secondary to a Spinal Extramedullary Tumor: Case report.- (29) Treatment of Syringomyelia on the Basis of Pathophysiological Changes in the Underlying Diseases.- (1) Legal Aspects of Obstetrical Ultrasound.- (2) Ultrasound and the Prenatal Diagnosis of Congenital Anomalies: A medicolegal perspective.- (1) Sacral Lipoma of the Filum Terminale with Dural Arteriovenous Fistula.- (2) On the Respiratory Distress in Meningomyelocele with Arnold-Chiari Malformation.- (3) Two Surgically Treated Neonatal Infants with Open Myelomeningocele and Associated Congenital Intrathoracic Cyst.- (4) MR Imaging Determination of the Location of the Normal Conus Medullaris Throughout Childhood.- (5) Diseases of the Spinal Canal in Children: Diagnosis with noncontrast CT scans.- (6) Comparison of Intracranial Pressure Between Spina Bifida Patients and Normal Subjects Using a Non-Invasive Pressure Assessment Technique.- (7) Closed Spinal Dysraphism: Analysis of clinical radiological, and surgical findings in 104 consecutive patients.- (8) Postoperative Follow-up Studies Using High Resolution Real-time Ultrasonography in Children with Overt and Occult Spinal Dysraphism.- (9) Thoracic and Lumbo-sacral Spinal Lipoma in an Infant.- (10) Terminal Myelocystocele Associated with Cloacal Exstrophy: Case report.- (11) Spina Bifida Associated with Subcutaneous Mass, Dural Ectasia and Thin Thoracic Spinal Cord.- (12) A Case of Diastematomyelia.- (13) Growth Hormone Treatment Accelerates Growth of Short Children with Neural Tube Defects.- Author Index.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisEarly diagnosis of parasitic diseases, especially of the opportunistic infections, is gaining importance daily and pathologists now have the chance to make rapid diagnoses of these disorders by examining tissues and body fluids. Though parasitic infections and infestations occur mainly in subtropical and tropical areas, they are increasingly imported into other areas, where the pathologist must be able to recognize them. This new full-colour atlas, containing over 500 photographs, many diagrams and tables, with extensive references and index, concentrates on histology, differential diagnosis and on the structure of parasitic elements such as eggs, larvae and adult worms, in and outside tissues. The atlas will be invaluable as a bench manual for the practising pathologists to keep by the microscope, as well as for physicians, surgeons, dermatologists and pathologists in training, and all those who are concerned with parasitic infections. Table of ContentsConsultant Editor's Note. Preface. I: Parasitic Diseases. II: Protozoan Diseases. Haemoflagellate Infections. 1. American Trypanosomiasis. 2. African Trypanosomiasis. Leishmaniases. 3. Cutaneous Leishmaniasis. 4. Muto-Cutaneous Leishmaniasis. 5. Visceral Leishmaniasis. 6. Giardiasis. 7. Trichomoniasis. 8. Amoebiasis. 9. Acanthamoebiasis. 10. Blastocystis Infection. 11. Toxoplasmosis. 12. Babesiosis. 13. Sarcosporidiosis. 14. Isosporosis. 15. Cryptosporidiosis. 16. Malaria. 17. Pneumocystosis. 18. Balantidiasis. 19. Microsporidiosis. III: Helminthic Diseases. A. Nematodiasis. 20. Enterobiasis. 21. Ascariasis. 22. Trichuriasis. 23. Uncinariasis. 24. Strongyloidiasis. 25. Trichinosis. 26. Toxocariasis. 27. Anisakiasis. 28. Gnathostomiasis. 29. Angiostrongylosis. 30. Capillariasis. 31. Dracunculosis. Filaria Infections. 32. Filariasis. 33. Loiasis. 34. Onchocerciasis. 35. Dirofilariasis.36. Rare and Uncommon Nematodiases. 37. Larva migrans. B. Cestodiasis. 38. Taeniasis. 39. Diphyllobothriasis. 40. Dipylidiasis. 41. Hymenolepiasis. 42. Cysticercosis. 43. Echinococcosis. C. Trematodiasis. 44. Blood Flukes. 45. Lung Flukes. 46. Liver Flukes. 47. Intestinal Flukes. D. Worm Eggs. IV: Disorders by Arthropods. 48. Scabies. 49. Demodicidosis. 50. Tungiasis. 51. Myiasis. 52. Pentastomiasis.

Read more less

Book SynopsisDermatopathology is both exciting and exasperating. tum corneum cells. This occurs in disorders of keratiniza­ Skin has an elegant simplicity in its functions yet a tion because the process of desquamation is disturbed (Figure 1. 1). ferocious complexity in its structure. This is one of the paradoxes that underly the pathology of skin disease Parakeratosis. The presence of nucleated horn cells in and may go some way in explaining the multitudinous the stratum corneum. Normally the horn cells (corneocy­ disorders to which the skin is subject. The ready visibility tes) are thin lamellae of less than 1 f. lm thickness. They of the skin may also help explain why straightforward contain no detectable cytoplasmic contents as these are histological examination cannot always provide an lost in the granular cell layer. Parakeratosis occurs when answer to a clinicians's question. Quite dramatic appear­ the process of keratinization is disturbed such as when ances may be due to alterations of the relative rates of the rate of epidermal cell production is increased (as in blood flow, with or without oedema, in the different psoriasis) so that nuclei are not broken down before the vascular plexuses or around different structures in the stratum corneum is reached and when damage occurs horizontal dimension, neither of which may result in to the upper epidermis (Figure 1. 2). 'much to see' histologically. The inherent sampling error Porokeratosis.Table of ContentsI.- 1 Normal skin.- 2 Reactions to trauma and vascular injury.- II.- 3 Infections.- 4 Disorders of keratinization.- 5 Bullous and vesicular skin disorders.- 6 Eczema, psoriasis, lichen planus.- 7 Other inflammatory diseases.- 8 Connective tissue disease, vasculitis and erythemas.- 9 Acne, rosacea, perioral dermatitis and related disorders.- 10 Miscellaneous disorders of connective tissue.- 11 Scalp and hair disorders.- 12 Cutaneous deposits in metabolic disorders.- III.- 13 Melanocytic naevi and malignant melanoma.- 14 Benign epidermal tumours and cysts.- 15 Premalignant and malignant lesions of epidermis.- 16 Tumours of the dermis.- 17 Lymphocytic, mast-cell and atypical histiocytic skin tumours and dermal leukaemia.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThis book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.Table of ContentsPart I Principles of Clinical Molecular DiagnosticsChapter 1 Molecules of Diseases and Their Detection Methods Chapter 2 Assay Performance Evaluation Chapter 3 Establishment of Biological Reference Interval Chapter 4 Ethics: Informed Consent, Patient Privacy Chapter 5 Bioinformatics Chapter 6 Report and Consultation Chapter 7 Factors Associated with Variation Chapter 8 Quality Control and Quality Assurance Chapter 9 Precision Medicine Part 2 Molecular Biomarkers and Signals from Diseased Functional Organ Chapter 10 Molecules in Body Systems Chapter 11 Molecules in Signal Pathways Chapter 12 Endocrine and Metabolism Chapter 13 Immune System Chapter 14 Lipoproteins Chapter 15 Transport and Carrier Proteins Chapter 16 Coagulation and Fibrinolysis Chapter 17 Cardiovascular System Chapter 18 Pregnancy Chapter 19 Urine Chapter 20 Bone Chapter 21 Cancer Chapter 22 Translation Research of Novel Biomarker Part 3 Advanced Molecular Diagnostic Techniques Chapter 23 Next-generation Sequencing (NGS) Chapter 24 Digital PCR Chapter 25 Biosensor Chapter 26 Microfluidic Chip Chapter 27 Liquid Biopsy Chapter 28 Molecular Targeted Imaging Chapter 29 Fluorescence in Situ Hybridization Chapter 30 Circulating DNA Quantification Chapter 31 DNA Methylation Detection Techniques Part 4 Disease Presentation and Clinical Laboratory Procedures Chapter 32 Immunological Disorders Chapter 33 Liver Diseases Chapter 34 Pancreatic Diseases Chapter 35 Digestive Tract Disease Chapter 36 Kidney Diseases Chapter 37 Cardiovascular Disease Chapter 38 Lung Disease Chapter 39 Blood Disorders Chapter 40 Endocrine and Metabolic Diseases Chapter 41 Neurological Disease Chapter 42 Reproductive Organ Cancer Chapter 43 Reproductive Organ Cancer Chapter 44 Transplant Matching Chapter 45 Paternity Test

Read more less

Book SynopsisSudden death is an uncommon condition. But when it occurs, especially in a young person, the acute loss can generate a substantial amount of grief with a great sense of disbelief. This mysterious and dreadful condition instils much fear and anxiety into the living, and more specifically for family members and friends. Understandably, the apprehension is brought about by the unexpectedness of the event and uncertainty of the consequences. The feeling of uneasiness is largely attributed to the lack of information regarding this condition. However in recent years, several causes of sudden death have been clarified. Treatment modalities have improved and reduced the occurrence of dying suddenly.This book is meant for anyone who wants to know more about sudden death. It aims to diminish its terror by explaining the various conditions that predispose individuals to sudden death and ways which may prevent it from occurring.

Read more less