Organic chemistry Books
Oxford University Press Stereoelectronic Effects
Book SynopsisEvery serious student of chemistry should try to develop a `feel'' for the way molecules behave - for the way they are put together and especially for the rules of engagement which operate when molecules meet and react. This primer describes how stereoelectronic effects control this behaviour. It is the only concise text on this topic at an undergraduate level. This is an important subject area and the comprehensive yet concise coverage in this book shows students how to build up a powerful but simple way of thinking about chemistry.Trade ReviewThe subject is presented authoritatively, systematically and concisely without resort to mathematical treatment. As this subject is often given little coverage in textbooks or organic chemistry this text is to be welcomed. * Aslib Book Guide, vol.61, no.11, November 1996 *This book is a useful introduction to stereo-electronic effects in organic chemistry. The style is engaging ... this book is an excellent supplementary text for undergraduates. Sponsorship for the series by Zeneca also ensures that it is extremely good value for money. * Chemistry in Britain, September 1997 *engaging critique of biography .... enjoyable and thought provoking * New Scientist *Table of ContentsIntroduction ; 1. The electronic basis of stereoelectronic effects ; 2. Effects on conformation ; 3. Effects on reactivity ; 4. Substitutions at saturated centres ; 5. Additions and eliminations ; 6. Rearrangements and fragmentations ; 7. Radical reactions
£29.99
Oxford University Press Why Chemical Reactions Happen
Book SynopsisBy tackling the most central ideas in chemistry, Why Chemical Reactions Happen provides the reader with all the tools and concepts needed to think like a chemist. The text takes a unified approach to the subject, aiming to help the reader develop a real overview of chemical processes, by avoiding the traditional divisions of physical, inorganic and organic chemistry. To understand how chemical reactions happen we need to know about the bonding in molecules, how molecules interact, what determines whether an interaction is favourable or not, and what the outcome will be. Answering these questions requires an understanding of topics from quantum mechanics, through thermodynamics, to curly arrows. In this book all of these topics are presented in a coherent and coordinated fashion, showing how each leads to a deeper understanding of chemical reactions.Trade ReviewI feel that Peter and James have done a tremendous job of explaining chemical reactions using perspectives that are not used in traditional text books. They explain reactions in terms of bonding theories and orbitals rather than solely using kinetics and equilibrium. The author's use of visual representations throughout the book increases the comprehension of the material covered in the text. I look forward to using this textbook in my organic chemistry courses. Physical Sciences Educational Reviews 2004.'Why Chemical Reactions Happen is one of nature's secrets....This insightful book reveals in clear and impressive style what motivates molecules to metamorphose into something new. It supplies all the essentials for understanding entrophy and how to choreograph molecular transformations to its music' Times Higher Education Supplement, February 2004.Table of Contents1. What this book is about and who should read it ; 2. What makes a reaction go? ; 3. Ionic interactions ; 4. Electrons in atoms ; 5. Electrons in simple molecules ; 6. Electrons in larger molecules ; 7. Reactions ; 8. Equilibrium ; 9. Rates of reaction ; 10. Bonding in extended systems - conjugation ; 11. Substitution and elimination reactions ; 12. The effects of the solvent ; 13. Leaving groups ; 14. Competing reactions
£36.99
Oxford University Press Pericyclic Reactions
Book SynopsisThe renowned Oxford Chemistry Primer series, which provides focused introductions to a range of important topics in chemistry, has been refreshed and updated to suit the needs of today''s students, lecturers, and postgraduate researchers. The rigorous, yet accessible, treatment of each subject area is ideal for those wanting a primer in a given topic to prepare them for more advanced study or research. Moreover, cutting-edge examples and applications throughout the texts show the relevance of the chemistry being described to current research and industry. Learning features provided in the primers, including questions at the end of every chapter and interactive online MCQs, encourage active learning and promote understanding. Furthermore, frequent diagrams, margin notes, further reading, and glossary definitions all help to enhance a student''s understanding of these essential areas of chemistry.Pericyclic reactions constitute a major strand of organic chemistry, including such commerciTable of Contents1. The nature of pericyclic reactions ; 2. Cycloaddition reactions ; 3. The Woodward-Hoffmann rules and molecular orbitals ; 4. Electrocyclic reactions ; 5. Sigmatropic rearrangements ; 6. Group transfer reactions
£31.99
Springer Nature Polymer Blends and Composites
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£74.25
Springer-Verlag New York Inc. Advanced Organic Chemistry
Book Synopsis1: Chemical Bonding and Molecular Structure.- 2: Stereochemistry, Conformation, and Stereoselectivity.- 3: Structural Effects on Stability and Reactivity.- 4: Nucleophilic Substitution.- 5: Polar Addition and Elimination Reactions.- 6: Carbanions and Other Carbon Nucleophiles.- 7: Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- 8: Aromaticity.- Aromatic Substitution.- 9: Concerted Pericyclic Reactions.- 10: Free Radical Reactions.- 11: Photochemistry.Trade ReviewFrom the reviews of the fifth edition:“Carey and Sundberg had written the most detailed and briliant account in the subject of organic chemistry. … The book provides an abundance of reaction examples organized in schemes. It makes studying very effective and helpful. … Advanced undergraduates and graduate students will welcome this new edition and the depth of materials covered.” (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, May, 2014)Table of ContentsChemical Bonding and Molecular Structure.- Stereochemistry, Conformation, and Stereoselectivity.- Structural Effects on Stability and Reactivity.- Nucleophilic Substitution.- Polar Addition and Elimination Reactions.- Carbanions and Other Carbon Nucleophiles.- Addition, Condensation and Substitution Reactions of Carbonyl Compounds.- Aromaticity.- Aromatic Substitution.- Concerted Pericyclic Reactions.- Free Radical Reactions.- Photochemistry.
£71.99
Springer Biotechnology and Pharmacy
Book SynopsisSection I Basic Elements of Biotechnology.- 1. Background to Recombinant DNA Technology.- 2. Background to Monoclonal Antibodies.- 3. Lymphokines and Monokines.- 4. Analytical Methods in Biotechnology.- 5. The Impact of Biotechnology on Analytical Methodology.- 6. Drug Delivery Aspects of Biotechnology Products.- Section II Applications of Biotechnology in the Pharmaceutical Sciences.- 7. Applications of Recombinant DNA Technology to the Diagnosis of Genetic Disease: Molecular Methods for Detecting the Genetic Basis of Diseases.- 8. Human Genome Mapping and Sequencing: Applications in Pharmaceutical Science.- 9. Clinical Use of Monoclonal Antibodies.- 10. Anti-AIDS Drug Development.- 11. Oral Adenoviruses as the Carriers for Human Immunodeficiency Virus or Hepatitis B Virus Surface Antigen Genes.- 12. The Use of Nonclassical Techniques in the Production of Secondary Metabolites by Plant Tissue Cultures.- 13. Applications of Biotechnology in Drug Discovery and Evaluation.- 14. Peptide Turn Mimetics.- Section III Biotechnology and the Practice of Pharmacy.- 15. Biotechnology Products: An Overview.- 16. The Pharmacist Practitioner's Role in Biotechnology: Clinical Application of Biotechnology Products.- 17. Human Trials of Biotechnology Products: A Perspective.Trade Review`Preparations, analytical methods, and current and possible applications for the products are presented well, along with accompanying references for further study. The book is remarkably free of the jargon that one finds in the specialists' literature.' Chemical Monographs ReviewTable of ContentsContributors. Preface. Part I: Basic elements of biotechnology: Background to recombinant DNA technology; L.G. Davis. Background to monoclonal antibodies; M.E. Klegerman. Lymphokines and monokines; M.E. Klegerman, N.P. Plotnikoff. Analytical methods in biotechnology; R.J. Prankerd, S.G. Schulman. The impact of biotechnology on analytical methodology; J.F. Fitzloff. Drug delivery aspects of biotechnology products; D.J. Burgess. Part II: Applications of biotechnology in the pharmaceutical sciences: Applications of recombinant DNA technology to the diagnosis of genetic disease: molecular methods for detecting the genetic basis of diseases; D.R. Maglott, W.C. Nierman. Human genome mapping and sequencing: implications and applications in the pharmaceutical science; C.E. Hildebrand, R.L. Stallings, D.C. Torney, J.W. Fickett, N.A. Doggett, D.A. Nelson, A.A. Ford, R.K. Moyzis. Clinical use of monoclonal antibodies; J.M. Brown. Anti-AIDS drug development; P. Mohan. Oral adenoviruses as the carriers for human immunodeficiency virus of hepatitis B virus surface antigen genes; M.D. Lubeck, S. Mizutani, A.R. Davis, P.P. Hung. The use of nonclassical techniques in the production of secondary metabolites by plant tissue cultures; B. O'Keefe, C.Wm.W. Beecher. Applications of biotechnology in drug discovery and evaluation; C.K. Angerhofer, J.M. Pezzuto. Peptide turn mimetics; M.E. Johnson, M. Kahn. Part III: Biotechnology and the practice of pharmacy: Biotechnology products: an overview; D. Brixner. The pharmacist practitioner's role in biotechnology: clinical application of biotechnology products; J.P. Engle, D.M. Kraus, L.S. Parent, M. Dean-Holland. Human trials of biotechnology products: a perspective; W. Leigh Thompson. Index.
£44.99
Elsevier Science Chalcones and their Derivatives
£160.00
Elsevier Science Phosphonate Chemistry
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£146.69
Elsevier Science Advances in Physical Organic Chemistry
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£168.15
Elsevier Science Progress in Medicinal Chemistry
Book SynopsisWhat defines a quality lead, where these quality leads come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry. This volume addresses these questions and discusses diabetes, obesity and tuberculosis. It presents research in the field of drug discovery.Table of ContentsPreface List of Contributors Hit and Lead Identification: Efficient practices for drug discovery DPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes Recent Progress Towards Nonpeptide Ligands for the Melanocortin-4 Receptor Tuberculosis chemotherapy: recent developments and future perspectives Subject Index Author Index (Volumes 1-45) Subject Index (Volumes 1-45)
£151.05
Wiley Dynamics of Polymeric Liquids 2 Volume Set
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£413.06
Royal Society of Chemistry KnowledgeBased Expert Systems in Chemistry
Book SynopsisThis is currently the only book available on the development of knowledge-based, and related, expert systems in chemistry and toxicology. Written by a pioneer in the field, it shows how computers can work with qualitative information where precise numerical methods are not satisfactory. An underlying theme is the current concern in society about the conflicts between basing decisions on reasoned judgements and wanting precise decisions and measurable effectiveness. As well as explaining how the computer programs work, the book provides insights into how personal and political factors influence scientific progress. The introduction of regulations such as REACH in Europe and modifications to UN and OECD Guidelines on assessment of chemical hazard mean that the use of toxicity prediction is at a turning point. They put a heavy burden on the chemical industry but, for the first time, allow for the use of computer prediction to support or replace in vivo and in vitro experiments. There is iTable of ContentsIntroduction Knowledge-Based Approach to Synthesis Planning EROS and CAMEO Spin-off from the Harvard project Structure, sub-structure and super-structure searching - technical Structure representations Explicit and implicit hydrogen atoms Aromaticity, tautomerism, stereochemistry Predicting toxicity - DEREK PHARM-MATCH and TOX-MATCH, Oncologic, and HazardExpert TopKat and Multicase The 2D/2.5D/3D debate Using reasoning - Derek for Windows Predicting metabolism - Meteor Relative reasoning Biodegradation Other potential applications Consensus modelling Evaluation and Validation Conclusions/Where now?
£115.89
CRC Press Essential Oils
Book Synopsis
£55.09
CRC Press Chemical and Clinical Applications of Tempol
Book SynopsisA comprehensive and authoritative exploration of Tempol (4-Hydroxy-TEMPO), an exceptional chemical compound with diverse applications in both scientific research and medical practice. This book delves into Tempol's unique properties, mechanisms of action, and its potential role in combating oxidative stress-related disorders. Includes a chapter devoted to the safe handling, storage, and disposal of Tempol in compliance with pharmaceutical regulations. The authors pay particular attention to pharmaceutical regulations in the industry. This book offers an in-depth exploration of Tempol (4-Hydroxy-TEMPO), covering its chemical, pharmaceutical, and medical applications, making it a valuable resource for researchers, academicians, and industry professionals. The chapters bridge chemistry, pharmacology, and medical sciences, detailing Tempolâs role in various fields such as terpenoid synthesis, cancer therapy, diabetic nephropathy, and ocular neuroprotection.
£47.49
John Wiley & Sons Inc Catalytic Asymmetric Synthesis
Book SynopsisCatalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis CH bond functionalization reactions Carboncarbon bond formation reactions, carbonhalogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric syntTable of ContentsPreface ix Preface to the First Edition xi List of Contributors xiii Part I Asymmetric Organocatalysis 1 1 Asymmetric Enamine and Iminium Ion Catalysis 3Yujiro Hayashi 2 Asymmetric Acid Organocatalysis 29Takahiko Akiyama 3 Asymmetric Base Organocatalysis 81Azusa Kondoh and Masahiro Terada 4 Asymmetric Phase-Transfer and Ion-Pair Organocatalyses 117Edward Miller, Patrick J. Moon, and F. Dean Toste 5 Asymmetric Peptide Catalysis 157Kazuaki Kudo 6 Asymmetric Carbene Catalysis: A Brief Highlight of Developments in the Past Decade 199Jia-Lei Yan, Hongling Wang, and Yonggui Robin Chi 7 Asymmetric Hypervalent Iodine Catalysis 243Muhammet Uyanik and Kazuaki Ishihara Part II Asymmetric Photochemical Reactions and Photoredox Catalysis 277 8 Asymmetric Visible-Light Photoredox Catalysis 279Jiyuan Lyu, Aurélie Claraz, and Géraldine Masson 9 Asymmetric Photoredox Reactions without Photocatalysts 329Dengke Ma, Thomas Hin-Fung Wong, and Paolo Melchiorre 10 Enantioselective Photochemical [2+2] Cycloaddition Reactions 355Freya M. Harvey and Thorsten Bach Part III Asymmetric Synthesis Through C–H Bond Activation 385 11 Asymmetric C–H Functionalization of C(sp2)–H Bond 387Uttam Dhawa, Tomasz Wdowik, and Lutz Ackermann 12 Asymmetric C–H Functionalization of C(sp3)–H Bond 429Xiao Zhang, Yangyang Shen, Eva Bednáŕová, and Tomislav Rovis Part IV Asymmetric Synthesis Through Carbon–Halogen Bond Formation and Enzyme Catalysis 491 13 Asymmetric Carbon–Halogen Bond Forming Reactions (Excluding C–H Activation Processes) 493Santos Fustero, Attila M. Remete, Loránd Kiss, Mercedes Medio-Simón, Jorge Escorihuela, and Daniel M. Sedgwick 14 Enzyme-Catalyzed Asymmetric Synthesis 531Gonzalo de Gonzalo and Andrés R. Alcántara Part V Asymmetric Hydrogenation 559 15 Asymmetric Hydrogenation 561Anton Vidal-Ferran, Arnald Grabulosa, Xavier Verdaguer, and Antoni Riera Part VI Asymmetric Carbon–Carbon Bond Forming Reactions Chapter 61716 Asymmetric Nucleophilic Addition to Ketones and Ketimines and Conjugate Addition Reactions 619Luo Ge and Syuzanna R. Harutyunyan 17 Asymmetric Allylic Alkylation, Allylation, and Related Reactions 661Tyler J. Fulton, Yun E. Du, and Brian M. Stoltz 18 Asymmetric Carbometallations Including Carbocyclizations 705Ken Tanaka Part VII Asymmetric Synthesis of Non-Centro- Chiral Compounds 727 19 Asymmetric Synthesis of Axially Chiral Compounds 729Shaohua Xiang, Jun Kee Cheng, and Bin Tan 20 Asymmetric Synthesis of Planar Chiral and Helically Chiral Compounds 769Takanori Shibata Part VIII Asymmetric Polymerization 803 21 Asymmetric Polymerization 805Jie Li and Xiao-Bing Lu Part IX Asymmetric Catalysis in Continuous-Flow System 831 22 Continuous-Flow Chemistry in Catalytic Asymmetric Synthesis 833Haruro Ishitani, Yuki Saito, and Shuˉ Kobayashi Index 869
£187.20
Royal Society of Chemistry Semiconducting Polymers: Controlled Synthesis and
Book SynopsisSemiconducting polymers are of great interest for applications in electroluminescent devices, solar cells, batteries and diodes. In recent years vast advances have been made in the area of controlled synthesis of semiconducting polymers, specifically polythiophenes. The book is separated into two main sections, the first will introduce the advances made in polymer synthesis, and the second will focus on the microstructure and property analysis that has been enabled because of the recent advances in synthetic strategies. Edited by one of the leaders in the area of polythiophene synthesis, this new book will bring the field up to date with more recent models for understanding semiconducting polymers. The book will be applicable to materials and polymers chemists in industry and academia from postgraduate level upwards.Table of ContentsControlled Synthesis of Conjugated Polymers in Catalyst-Transfer Condensation Polymerization: Monomers and Catalysts; Controlled Chain-Growth Synthesis of Conjugated Polymers: Moving Beyond Thiophene; Application of Catalyst Transfer Polymerizations: From Conjugated Copolymers to Polymer Brushes; Controlled Synthesis of Chain End Functional, Block and Branched Polymers Containing Polythiophene Segments; Characterization of Polymer Semiconductors by Neutron Scattering Techniques; Structural Control in Polymeric Semiconductors: Application to the Manipulation of Light-Emitting Properties; Structure and Order in Organic Semiconductors
£151.05
Royal Society of Chemistry The Chemistry of Plants and Insects: Plants,
Book SynopsisHave you ever wondered how plants attract certain insects, or how insects communicate with each other? This book explains the natural chemical compounds that determine the fascinating interactions between plants and insects providing a gentle and absorbing introduction to organic chemistry that is highly relevant to everyday life and to the natural world. Specific organic compounds and intriguing chemistry determine whether insects are keen on feeding on plants or avoid certain plants altogether. Some insects have learned to use plant compounds as their own defences, and some plants use digestive processes to use insects as nutritional supplements. Plant-insect interactions are vital for our food supply, for pollination of orchards or detrimentally in insect infestations of crops, as well as in applications like silk production. By the author of the popular book, The Chemistry of Plants: Perfumes, Pigments, and Poisons, this book benefits from Margareta Séquin’s vast experience leading field trips and seminars to botanical gardens and nature reserves, and teaching chemistry to beginners. Organic chemistry is often seen as a challenging, sometimes abstract field. This book makes chemistry exciting and accessible for readers interested in a deeper understanding of the natural world. The book is organized according to the increasing complexity of compounds introduced, and so it also serves as a useful teaching aid for undergraduate chemistry or biology courses, and as a supplementary text for students in plant sciences, ecology, and entomology, and in horticultural programs.Trade ReviewThis fluently written book is illustrated by well-chosen colour photos and numerous chemical formulae as well as some tabulation of data such as one showing the composition of the synthetic medium used to feed pea aphids. This involves having a detailed knowledge of insects’ dietary needs, which are surprisingly complex. I found it interesting to read that the reason that pheromones have odd numbers of carbon atoms in each molecule is because of the mechanism by which insects synthesise them. After reading this book one comes away with the feeling that there is a lot more to be learned from this topic, particularly by those who would like to move away from using environmentally unfriendly sprays in favour of more targeted approaches. -- John Edmondson, Royal Botanic Gardens, Kew, Richmond, UK * Chromatographia, https://doi.org/10.1007/s10337-019-03787-w *Table of ContentsThe Chemistry of Plants and Insects; Plants Attracting Insects; Plants That Eat Insects; Plants' Defence Against Insects; Insects and Their Chemistry; Insects Feeding on Plants; Plant Galls: Protection and Food for the Young; Insects That Use Plant Defenses for Their Own Protection; Insects That Provide Protection for Plants; Human Uses; Plant-Insect Interactions and the Human Role
£26.59
Royal Society of Chemistry Conference on Drug Design and Discovery
Book SynopsisThis publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.Table of ContentsPart 1: Structure Based Drug Design Approach; MOLECULAR DYNAMICS SIMULATIONS ON BACILLUS SUBTILIS EngA – FOR EXPLORING NUCLEOTIDE DEPENDENT CONFORMATIONS; ERRORS MADE IN AB INITIO+ HOMOLOGY-BASED PROTEIN STRUCTURE PREDICTION TOOLS ARISE DUE TO LACK OF CONSIDERATION OF IMPACT FORCES; PARADIGM SHIFT IN RESEARCH FOCUS: COMPUTATIONAL SOFTWARES IN CANCER BIOLOGY; VIRTUAL SCREENING OF BIO-ACTIVE COMPOUNDS AS AN INHIBITOR OF C-FLIP PROTEIN FOR CANCER TREATMENT; FRAGMENT-BASED DESIGN OF NOVEL INHIBITORS OF HPV 16 E6 ONCOPROTEIN: MOLECULAR DOCKING, MOLECULAR DYNAMICS SIMULATION AND IN SILICO ADME ANALYSIS; DESIGN AND SYNTHESIS OF NOVEL POLY ADP-RIBOSE POLYMERASE 1 (PARP1) INHIBITORS FOR THE TREATMENT OF SOLID TUMORS; IN SILICO EVALUATION OF THE ROLE OF PHYTOCHEMICALS IN ALZHEIMER’S DISEASE THROUGH WNT SIGNALING MODULATION; IDENTIFICATION OF POTENTIAL VEGFR2 INHIBITORS EMPLOYING E-PHARMACOPHORE MODEL, VIRTUAL SCREENING, MOLECULAR DYNAMIC SIMULATION AND ADME ANALYSIS; DEVELOPMENT OF NEW NEPRILYSIN INHIBITOR AS A MODULATOR OF CHRONIC KIDNEY AND HEART DISEASE USING IN SILICO DRUG REPURPOSING APPROACH; ANTICANCER POTENTIAL OF PHYTOCONSTITUENTS MODULATING NA/ K ATPASE PUMP; A NOVEL REPURPOSING STRATEGY; IN SILICO HIT IDENTIFICATION, DRUG REPURPOSING, PHARMACOKINETIC AND TOXICITY PREDICTION OF c-MET KINASE INHIBITORS FOR CANCER THERAPY; DESIGN OF POTENT TELOMERASE INHIBITORS USING STRUCTURE BASED APPROACHES; MOLECULAR DOCKING BASED SCREENING OF “NITROGEN CONTAINING BISPHOSPHONATE CONJUGATE WITH HYDROXYAPETITE” ACTIVE CONSTITUENTS TOWARDS MELVONATE PATHWAY IN FINDING POTENT INHIBITORS FOR ANTI-OSTEOPOROTIC ACTIVITY; ZANAPEZIL, A POTENTIAL REPURPOSABLE DRUG AGAINST HUNTINGTON DISEASE: AN IN SILICO FORECAST; DRUG REPURPOSING FOR HEPATOCELLULAR CARCINOMA VIA VIRTUAL SCREENING INTEGRATED WITH BIOINFORMATICS ANALYSIS; AN IN SILICO TARGET SPECIFIC DRUG REPURPOSING APPROACH FOR MULTIPLE SCLEROSIS; Part 2: Structure Based Drug Design and Biological Evaluation; DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-PHENYLISOXAZOLO[5,4-D]PYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS.; QSAR AND DOCKING STUDIES ON TRIAZOLE BENZENE SULFONAMIDES WITH HUMAN CARBONIC ANHYDRASE IX INHIBITORY ACTIVITY; DESIGN AND SYNTHESIS OF SOME NOVEL ERLOTINIB DERIVATIVES AS POTENTIAL EGFR KINASE INHIBITORS; DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL SERIES OF 1,3-THIAZOLE CONTAINING HETEROCYCLES AS INHIBITORS OF DHFR FOR USE AS ANTICANCER AGENTS; IN SILICO AND IN VITRO STUDIES OF BENZOHYDRAZIDE ANALOGUES AS POTENT ANDROGEN RECEPTOR ANTAGONIST; DESIGN, MOLECULAR DOCKING, SYNTHESIS AND ANTI-FUNGAL ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES; SYNTHESIS, ANTIOXIDANT ACTIVITY AND COMPUTATIONAL STUDIES OF 2-SUBSTITUTED-L-THIAPROLINES; DESIGN, SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL ACTIVITY OF NOVEL PYRIMIDONE DERIVATIVES; Part 4: Chemical Synthesis and Biological Evaluation; MICROWAVE-ASSISTED SYNTHESIS OF 4-BENZYLIDENE-2-(2-FLUOROPHENYL) OXAZOL-5(4H)-ONE DERIVATIVES CATALYSED BY EGG SHELL POWDER AND EVALUATION OF THEIR ANTI-MICROBIAL ACTIVITY; SYNTHESIS OF OXAZOLOQUINOLONE DERIVATIVES AND EVALUATION OF THEIR POTENCY TO REACTIVATE RAT BRAIN ACETYLCHOLINESTERASE INHIBITED BY CHLORPYRIFOS; Part 5:
£118.75
Royal Society of Chemistry The Chemistry of Plants: Perfumes, Pigments and
Book SynopsisWhy are some plants so important to humans? The chemistry of the plants has a lot to do with it! The plant world offers a fascinating way to explore basic chemistry concepts. The spectacular variety of colors, fragrances and other characteristics of plants are driven by the seemingly subtle differences in the structure and properties of organic compounds. Well-known flowers, like daffodils and narcissus, are examples of plants that provide ample perfumes, pigments and poisons as part of their intricate and fascinating chemistry. This second edition retains it accessibility, expanding on the first edition and combining scientific concepts with colorful pictures and stories in simple, clear language. Readers will find introductory information on some chemistry and plant biology. This prepares them for the more complex chemical structures that compose plant substances, many of them of vital importance to humans. The final chapter has been expanded, in particular the sections on medicinal plants and on genetic modification. The end-of chapter references have been thoroughly updated with articles, books, and relevant websites that illustrate the topics discussed. Dr Margareta Sequin, an organic chemist and plant enthusiast, has taught popular undergraduate college level courses on plant chemistry to non-chemistry majors and has led numerous field seminars for the general public. The comments and questions from these audiences and the topics that especially captured people's interest have greatly shaped this book. The Chemistry of Plants addresses an audience with little previous chemistry knowledge, but will appeal to the expert reader looking for an understanding of more complex plant compounds. It can be used both as a text to introduce organic chemistry as it relates to plants and as a text of reference for more advanced readers.Table of ContentsBasic Plant Chemistry Concepts; The Molecular Building Blocks; Perfumes, Volatile Plant Scents; Colorful Plant Pigments; Poisons and Other Plant Defenses; Plants and People
£28.49
Royal Society of Chemistry Agri-food Waste Valorisation
Book SynopsisThe agri-food industry creates a vast amount of waste each year. This is not just a problem for waste management, in terms of finding space to store waste and preventing escape of harmful waste into the environment; it also represents a loss of resources: the chemicals and energy which have gone into the production of this waste. If current waste streams can be converted into useful resources this will have multiple benefits by reducing the amount of waste sent to landfill or similar, reducing the need for other feedstocks and removing the pressure from feedstocks that could be used as food. Research into the different types of waste produced by the agri-food industry and approaches to converting them into useful chemicals or chemical feedstocks has advanced rapidly over the last few years. Covering the latest developments in the valorisation of food and agricultural waste, such as valorisation of citrus peel and industrial wastes, this book is a great resource for researchers interested in waste management, sustainability and the circular economy.Table of ContentsValorisation of Agro-industrial Waste: Recent Advances in Recovery of Bioactive Compounds and Environmental Perspectives;Agri-food Waste: An Adjuvant for the Management of Oxidative Stress-related Disorders?;Sustainable Environmental Remediation by Valorization of Agro-food Industrial Waste and By-products;Valorisation of Coproducts and By-products Obtained from Nuts;Chemical and Biological Valorization of Tomato Waste;Agro-wastes for Cost-effective Production of Industrially Important Microbial Enzymes;Converting Agricultural Waste Biomass into Value-added Fuels via Thermochemical Processes;Agri-food Waste to Biofuels: Current Trends and Challenges;Valorization of Agricultural Residues Generated from Corn/Maize: Acquiring Valuables from Waste;Advanced Food Waste Valorization Techniques for Bioenergy Production: A Path in the Direction of Environmental Sustainability;Techno-economic Analysis for Low Cost In-vessel Food Waste Composting at Universiti Malaysia Sabah;Techno-economic Analysis and Life Cycle Assessment of Value-added Products from Agri-food Waste
£151.05
Royal Society of Chemistry An Introduction to Ionic Liquids
Book SynopsisIn the late 1990s, there was an explosion of research on ionic liquids and they are now a major topic of academic and industrial interest with numerous existing and potential applications. Since then, the number of scientific papers focusing on ionic liquids has risen exponentially, including a few edited multi-author books covering the latest advances in ionic liquids chemistry and several volumes of symposium proceedings. Much of the content in these books and volumes is written using technical jargon that only scientists at the cutting edge of ionic liquids research will understand and ionic liquids are hardly covered in most modern chemistry textbooks. This is the first single-author book on ionic liquids and the first introductory book on the topic. It is written in a clear, concise and consistent way. The book provides a useful introduction to ionic liquids for those readers who are not familiar with the topic. It is also wide ranging, embracing every aspect of the chemistry and applications of ionic liquids. The book draws extensively on the primary scientific literature to provide numerous examples of research on ionic liquids. These examples will enable the reader to become familiar with the key developments in ionic liquids chemistry over recent years. The book provides an introduction to: ionic liquids; their nomenclature; history; physical, chemical and biological properties; and their wide ranging uses and potential applications in catalysis, electrochemistry, inorganic chemistry, organic chemistry, analysis, biotechnology, green chemistry and clean technology. Notable and important chapters include "The Green Credentials of Ionic Liquids" and "Biotechnology." The chapter on "Applications" includes sections with brief descriptions of recent research on the development of ionic liquids: - for the construction of a liquid mirror for a moon telescope - for use as rocket propellants - for use as antimicrobial agents that combat MRSA - as active pharmaceutical ingredients and antiviral drugs - for embalming and tissue preservation Science students, researchers, teachers in academic institutions and chemists and other scientists in industry and government laboratories will find the book an invaluable introduction to one of the most rapidly advancing and exciting fields of science and technology today.Trade Review"If there ever was a case of a reporter becoming part of the story, it would have to be Michael FreemantleÆs pivotal role in the growth of the field now known as ionic liquids." Robin D.Rogers * Chemical and Engineering News, November 29th 2010, Robin D Rogers *"This well-crafted book by Freemantle is distinct from other recent volumes on the subject. à FreemantleÆs book begins with a review of IL synthesis and properties and then concisely describes the diverse applications and merits of ILs in many à of the areas in which they are currently used. This book is both scholarly and a great read. Summing Up: Highly recommended. Lower-division undergraduates through professionals."P. G. Heiden * Choice, Vol. 47 (11), August, 2010 *Table of ContentsChapter 1: Introduction; Chapter 2: History; Chapter 3: Synthesis of Ionic Liquids; Chapter 4: Properties of Ionic Liquids; Chapter 5: Ionic Liquids as Designer Solvents; Chapter 6: The Green Credentials of Ionic Liquids; Chapter 7: Electrochemistry; Chapter 8: Catalysis; Chapter 9: Inorganic Chemistry; Chapter 10: General Organic Reactions; Chapter 11: Named Organic Reactions; Chapter 12: Biotechnology; Chapter 13: Analysis; Chapter 14: Applications; Subject Index
£37.95
Royal Society of Chemistry New Synthetic Technologies in Medicinal Chemistry
Book SynopsisThe modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas. The chapters focus on topics including: parallel medicinal chemistry; solid supported reagents; microwave assisted chemistry; flow synthesis, and high throughput reaction screening.Trade Review" Elizabeth Farrant, a very experienced medicinal chemist, has collected six chapters written by experts in the field to create the book "New Synthetic Technologies in Medicinal Chemistry" ""...is well suited as an introductory course in to current trends of developing and employing enabling technologies in synthetic medicinal chemistry." * ChemMedChem 2012, 7, 1295 - 1298, Prof. Andreas Kirchning, *Table of ContentsIntroduction; Parallel Medicinal Chemistry; Solid Supported Reagents; Microwave Assisted Chemistry; Flow Synthesis; High Throughput Reaction Screening; Emerging Technologies
£94.99
Springer Nature Switzerland AG Betalains: Biomolecular Aspects
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£80.99
Springer Nature Switzerland AG Introduction to Ultrasound, Sonochemistry and Sonoelectrochemistry
Book SynopsisThis book provides an introduction to the fundamental and applied aspects of sonochemistry, discussing a number of basic concepts in sonochemistry, such as how ultrasonic waves interact with gas bubbles in liquids to generate cavitation, and how the high temperatures generated within cavitation bubbles could be estimated. It explains how redox radicals are produced and how to make use of both the physical and chemical forces generated during cavitation for various applications. Intended for academic researchers, industry professionals as well as undergraduate and graduate students, especially those starting on a new research topic or those new to the field, it provides a clear understanding of the concepts and methodologies involved in ultrasonic and sonochemistry.Table of ContentsIntroduction.- Interaction between Sound Waves and Bubbles.- Cavitation.- Physical and Chemical Forces Generated by Cavitation.- Brief Accounts on Sonochemistry, Sonoluminescence and Sonoelectrochemistry.
£40.49
Springer Nature Switzerland AG Brewing Science: A Multidisciplinary Approach
Book SynopsisThis updated text collects all the introductory aspects of beer brewing science into one place for undergraduate brewing science courses. This expansive and detailed work is written in conversational style, walking students through all the brewing basics from the origin and history of beer to the brewing process to post-brew packaging and quality control and assurance. As an introductory text, this book assumes the reader has no prior knowledge of brewing science and only limited experience with chemistry, biology and physics. The text provides students with all the necessary details of brewing science using a multidisciplinary approach, with a thorough and well-defined program of in-chapter and end-of-chapter problems. As students solve these problems, they will learn how scientists think about beer and brewing and develop a critical thinking approach to addressing concerns in brewing science. As a truly comprehensive introduction to brewing science, Brewing Science: A Multidisciplinary Approach, Second Edition walks students through the entire spectrum of the brewing process. The different styles of beer, the molecular makeup and physical parameters, and how those are modified to provide different flavors are listed. All aspects of the brewery process, from the different setup styles to sterility to the presentation of the final product, are outlined in full. All the important brewing steps and techniques are covered in meticulous detail, including malting, mashing, boiling, fermenting and conditioning. Bringing the brewing process full circle, this text covers packaging aspects for the final product as well, focusing on everything from packaging technology to quality control. Students are also pointed to the future, with coverage of emerging flavor profiles, styles and brewing methods. Each chapter in this textbook includes a sample of related laboratory exercises designed to develop a student’s capability to critically think about brewing science. These exercises assume that the student has limited or no previous experience in the laboratory. The tasks outlined explore key topics in each chapter based on typical analyses that may be performed in the brewery. Such exposure to the laboratory portion of a course of study will significantly aid those students interested in a career in brewing science.Table of ContentsChapter 1 – Introduction to Brewing Science 1.1 Science and the Brewer 1.1.1 The Scientific Method 1.2 What is Beer? 1.3 Some Common Conventions 1.3.1 Volume 1.3.2 Temperature 1.3.3 Weight 1.4 Yes Virginia, Beer contains Alcohol 1.5 A Short History of Beer in the World 1.5.1 The Very Early Years (pre-historic to Romans) 1.5.2 Beer in Europe before 1500 1.5.3 Colonization and the New World 1.5.4 Beer in Post-1700 Europe 1.5.5 Beer in the Far East 1.6 Beer in the United States 1.6.1 Beer unites the nation 1.6.2 Expansion across the west 1.6.3 Temperance and Prohibition 1.6.4 Prohibition in the US 1.6.5 Post-prohibition 1.6.6 Returning to the home 1.7 The Current Market for Beer Laboratory Exercises Familiarization with laboratory measurements Exploring the Internet Chapter 2 – Beer Styles 2.1 Judging Beer 2.1.1 Beer Styles 2.1.2 Conforming to a Style 2.2 Parameters that Classify a Beer Style 2.2.1 Physical Parameters 2.3 Common Beer Styles 2.3.1 Lagers 2.3.1.1 European Lagers 2.3.1.2 English Lagers 2.3.1.3 American Lagers 2.3.1.4 Other Lagers 2.3.2 Ales 2.3.2.1 European Ales 2.3.2.2 English, Scottish and Irish Ales 2.3.2.3 American Ales 2.3.3 Hybrids (talk about Calif. Common, etc…) 2.4 Historical Beer Styles 2.5 How to Sample and Taste Beer 2.5.1 Beer Glasses 2.5.2 Serving Temperature 2.5.3 Sampling and Tasting Laboratory Exercises Density measurements SRM Determination Chapter 3 – Molecules and Other Matters 3.1 The Atom 3.1.1 Compounds 3.2 Laws that Govern Atoms, Molecules, and Ionic Compounds 3.3 The World of Carbon-Containing Molecules 3.3.1 Basic Functional Groups in Brewing 3.3.2 Amino acid polymers 3.3.3 Drawing Organic Molecules 3.3.4 Naming Organic Molecules 3.4 Reactions of Organic Molecules 3.4.1 Oxidation and Reduction 3.4.2 Condensation Reactions 3.4.3 Isomerization Reactions 3.4.4 Radical Reactions 3.4.5 Maillard Reactions Laboratory Exercises Building models in 3-D Chapter 4 – Overview of the Brewing Process 4.1 Overview of the Process 4.1.1 Agriculture 4.1.2 Malting 4.1.3 Milling 4.1.4 Mashing 4.1.5 Lautering and Sparging 4.1.6 Boiling 4.1.7 Fermentation 4.1.8 Maturation 4.1.9 Filtration 4.1.10 Packaging 4.2 Cleaning and Sterilizing 4.3 Inputs and Outputs 4.3.1 Water 4.3.2 Grains and Malts 4.3.3 Hops 4.3.4 Yeast 4.3.5 Finished product Laboratory Exercises Sketch the overview Research on Barley Chapter 5 – Malting and Water 5.1 Biology of Barley 5.1.1 The Barley Corn 5.1.2 Barley and the Farmer 5.1.3 Barley Diseases and Pests 5.1.4 Sorting and Grading 5.2 Malting Barley 5.2.1 Germination of Barley 5.2.2 Equipment used in Malting 5.2.3 Problems Arising from Malting 5.3 Maillard Reactions 5.4 Water – the most important ingredient 5.4.1 Types of water 5.4.1.1 Aquifers 5.4.1.2 Brewery Water 5.4.2 What’s in the water? 5.4.2.1 Cations in water 5.4.2.2 Anions in water 5.4.2.3 Reactions in water 5.4.3 pH 5.4.3.1 Residual Alkalinity Laboratory Exercises Germination of barley Chapter 6 – Milling and Mashing 6.1 Milling 6.1.1 Purpose of milling 6.1.2 Equipment used in milling 6.2 Purpose of mashing 6.3 Equipment used in Mashing 6.3.1 Cereal Cookers 6.3.2 Mash Mixer and Mash Kettles 6.3.3 Mash Tun 6.3.4 Processes in Mashing 6.4 Enzymes and what they are 6.5 Chemistry while Resting 6.5.1 Starch 6.5.1 Phytase 6.5.2 Glucanase 6.5.3 Proteases and peptidases 6.5.4 Alpha-amylase 6.5.5 Beta-amylase 6.5.6 Mashout 6.6 Efficiency of Extraction 6.6.1 Efficiency Calculations 6.6.2 Mash pH 6.6.3 Mash Thickness Laboratory Exercises The Effect of Temperature and pH on Mashing Efficiency Chapter 7 – Lautering and Sparging 7.1 Introduction 7.2 Fluid physics: Static case 7.2.1 Pressure 7.2.2 Pascal’s Law 7.3 Fluid Physics: Dynamic case 7.3.1 Conservation of mass: the continuity equation 7.3.2: Bernoulli’s principle and laminar flow 7.3.3 Pressure and Hydraulic Head 7.3.4 Head and Pump Dynamics. 7.3.5 Darcy’s Law and laminar flow in porous media 7.4 Equipment used in Sparging and Lautering 7.4.1 Batch Sparging 7.4.2 Fly Sparging 7.4.3 Mash Filter 7.5 When do we stop sparging? Laboratory Exercises Exploring Darcy’s law Chapter 8 – Boiling 8.1 Why Boil the Wort? 8.2 The Equipment of the Boil 8.2.1 Metals and Heating 8.2.2 Corrosion 8.2.3 Methods for Heating 8.2.4 Direct Fire Vessels 8.2.5 Calandria 8.2.6 Other Heating Systems 8.3 Heat and Temperature 8.3.1 Types of Energy 8.4 Heat Capacity and Heat Transfer 8.4.1 Phase Transition – Boiling 8.4.2 Power 8.5 Hops in the Boil 8.5.1 The hop flower revisited 8.5.2 Hop Oil Constituents 8.5.3 Modified Hop Oils Laboratory Exercises Hop Tea and Identifying Flavors Determination of Percent Hop Acids in Hops. Determination of Wort Viscosity during Boil. Chapter 9 – Cooling and Fermenting 9.0 Setting the Stage 9.1 Wort Chilling 9.1.1 Heat Exchangers 9.1.2 Multiple stage heat exchangers 9.2 Equipment used in Fermentation 9.2.1 Refrigeration 9.2.1.1 Introductory Thermodynamics. State variables and processes. 9.2.1.2 Internal energy and the first law of thermodynamics 9.2.1.3 Thermodynamic Processes 9.2.1.4 Reversible and irreversible processes in thermodynamics 9.2.1.5 The most efficient cycle: The Carnot cycle. 9.2.1.6 Type of refrigerants. 9.2.1.7 Mechanical implementation of refrigeration. Glycol circulation. 9.2.2 Fermenters, CCV, round squares. 9.2.2.1 Aeration and pressure effects 9.3 Yeast 9.3.1 Yeast Morphology 9.3.2 Yeast Metabolism 9.3.2.1 Aerobic Conditions 9.3.2.2 Anaerobic Conditions 9.3.2.3 Effects on metabolism 9.3.3 Products of Yeast Laboratory Exercises The Effect of Sugars on Fermentation Chapter 10 – Maturation and Carbonation 10.1 The purpose of maturation 10.1.1 Secondary fermentation 10.1.2 Warm maturation 10.1.3 Cold maturation 10.1.4 Other adjustments 10.2 Equipment Used in Maturation 10.2.1 Horizontal versus Vertical 10.2.2 Cask Conditioning 10.3 Carbonation 10.3.1 The principles of carbonation 10.3.2 Equipment used to Carbonate 10.3.2.1 Inline methods 10.3.2.2 Online methods 10.3.3 Issues with Carbonation Laboratory Exercises Diacetyl Determination in Beer Adjusting the Color Chapter 11 – Clarification and Filtration 11.1 Introduction 11.2 Colloids and Colloidal Stability 11.2.1 What is a colloid? 11.2.2 Formation in beer 11.2.3 Turbidity Measurements 11.2.4 Shelf-life 11.3 Clarification 11.3.1 During Boiling 11.3.2 During Fermentation 11.3.3 During Maturation 11.4 Filtration 11.4.1 Principles of filtration 11.4.2 Filtration equipment 11.4.2.1 The Sheet Filter 11.4.2.2 The Lenticular Filter 11.4.2.3 Powder Filters (Candle, Leaf, and Plate&Frame Filters) 11.4.2.4 Crossflow Filters 11.4.3 Issues with Filtration 11.4.3.1 Product Safety Hazards 11.4.3.2 Product Quality Hazards 11.4.3.3 Operator Safety Hazards Chapter 12 – Packaging 12.1 Introduction 12.2 Carbonation and Other Gases 12.2.1 Pressure Loss in Transferring Liquids 12.2.2 Temperature Increases during production 12.2.3 Other Gases used in “carbonation” 12.3 Packaging 12.3.1 Small Pack 12.3.1.1 Bottles 12.3.1.2 Cans 12.3.1.3 Plastic 12.3.2 Large Pack 12.4 Pasteurization 12.4.1 Tunnel Pasteurization 12.4.2 Flash Pasteurization 12.4.3 Other methods of Pasteurization Laboratory Exercises Thermal Expansion of Water Chapter 13 – Quality Assurance and Quality Control 13.1 What is Quality? 13.1.1 Quality for the Consumer 13.1.2 Quality for the Brewery 13.1.3 What Quality is not 13.2 Quality Control 13.2.1 Methods in Quality Control 13.3 Quality Assurance 13.3.1 Good Brewery Practice 13.3.2 Addressing production using PDCA 13.4 Addressing Product Safety 13.4.1 FSMA 13.4.2 HACCP 13.5 Sensory Analyses 13.5.1 Types of sensory evaluations 13.6 Safety in the Brewery Laboratory Exercises Turbidity in Beer Appendix A – Math for the Brewer A.0 Introduction A.1 Designing your brew A.1.1 Volume. A.1.2 Designing the Grain Bill A.1.3 Hops A.1.4 Percent alcohol by volume (ABV) A.1.5 Color and SRM A.2 Misc - Strike water temperature Appendix B – R134a Refrigerant Data B.0 Introduction B.1 Saturated, organized by Temperature B.2 Saturated, organized by pressure B.3 Superheated Vapor Appendix C – Sensory Statistical Data C.0 Introduction C.1 Difference Testing Statistics
£85.49
De Gruyter Chemistry of Nucleic Acids
Book SynopsisLife in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.
£59.25
Springer International Publishing AG Brewing Science: A Multidisciplinary Approach
Book SynopsisThis text finally collects all the introductory aspects of beer brewing science into one place for undergraduate brewing science courses. This expansive and detailed work is written in conversational style, walking students through all the brewing basics from the origin and history of beer to the brewing process to post-brew packaging and quality control and assurance. As an introductory text, this book assumes the reader has no prior knowledge of brewing science and only limited experience with chemistry, biology and physics. The text provides students with all the necessary details of brewing science using a multidisciplinary approach, with a thorough and well-defined program of in-chapter and end-of-chapter problems. As students solve these problems, they will learn how scientists think about beer and brewing and develop a critical thinking approach to addressing concerns in brewing science. As a truly comprehensive introduction to brewing science, Brewing Science: A Multidisciplinary Approach walks students through the entire spectrum of the brewing process. The different styles of beer, the molecular makeup and physical parameters, and how those are modified to provide different flavors are listed. All aspects of the brewery process, from the different setup styles to sterility to the presentation of the final product, are outlined in full. All the important brewing steps and techniques are covered in meticulous detail, including malting, mashing, boiling, fermenting and conditioning. Bringing the brewing process full circle, this text covers packaging aspects for the final product as well, focusing on everything from packaging technology to quality control. Students are also pointed to the future, with coverage of emerging flavor profiles, styles and brewing methods. Each chapter in this textbook includes a sample of related laboratory exercises designed to develop a student’s capability to critically think about brewing science. These exercises assume that the student has limited or no previous experience in the laboratory. The tasks outlined explore key topics in each chapter based on typical analyses that may be performed in the brewery. Such exposure to the laboratory portion of a course of study will significantly aid those students interested in a career in brewing science.Table of ContentsIntroduction to Brewing Science.- Beer Styles.- Molecules and Other Matters.- Overview of the Brewing Process.- The Food for the Brew.- Mashing.- Sparging.- Wort Boiling.- Cooling and Fermenting.- Conditioning.- Packaging.- Quality Assurance and Quality Control.- Appendix A.- Appendix B.
£52.24
Springer International Publishing AG Guanidines as Reagents and Catalysts I
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£161.99
Wiley-VCH Verlag GmbH Classics in Total Synthesis: Targets, Strategies,
Book SynopsisK.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.Table of ContentsConstructing the Molecules of Nature Strychnine (Woodward) Strychnine (Overman) Penicillin V (Sheehan) Reserpine (Woodward) Vitamin B12 (Woodward) Progesterone (Johnson) Prostaglandins F2-alpha and E2 (Corey) Prostaglandins A2 and F2-alpha (Stork) Carpanone (Chapman) Monensin (Kishi) Monensin (Still) Biotin (Baggiolini) Periplanone B (Still) Periplanone B (Schreiber) Isocomene (Pirrung) Estrone (Vollhardt) Erythronolide B (Corey) Endiandric Acids A-G (Nicolaou) Thienamycin (Merck) Asteltoxin (Schreiber) Amphotericin B (Nicolaou) L-Hexoses (Masamune & Sharpless) Cytovaricin (Evans) Indolizamycin (Danishefsky) Ginkgolide B (Corey) Paoniflorigenin and Paoniflorin (Corey) Methyl homosecodaphniphyllate (Heathcock) Gilvocarcin M and V (Suzuki) Calicheamicin gamma-1I (Nicolaou) Taxol (Nicolaou) Rapamycin (Nicolaou) Menthol (Noyori) Palytoxin (Kishi) Brevetoxin B (Nicolaou)
£81.70
Wiley-VCH Verlag GmbH Biomedical Applications of Extracellular Vesicles
Book SynopsisBiomedical Applications of Extracellular Vesicles Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more. The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented. Sample topics covered in Biomedical Applications of Extracellular Vesicles include: Biogenesis of various EVs Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.Table of ContentsPreface xi 1 Extracellular Vesicles and Their Biomedical Applications: An Overview 1 Xing-Jie liang, Ke Cheng, and Zhenhua li 1.1 Introduction 1 1.2 Biogenesis and Composition of Extracellular Vesicles 1 1.3 Biological Functions of Extracellular Vesicles 2 1.4 Extracellular Vesicles Isolation and Limitations 3 2 Biogenesis and Identification of Extracellular Vesicles 5 Dandan Ding, Xing Zhang, Yu Zhao, Xiaoya Li, Qingqing Leng, and Zhenhua li 2.1 Biogenesis of Extracellular Vesicles 5 2.1.1 Biogenesis of Exosome 6 2.1.2 Biogenesis of Microvesicle 8 2.1.3 Biogenesis of Apoptotic Bodies 8 2.1.4 Biogenesis of Large Oncosomes 9 2.2 Identification of Extracellular Vesicles 9 2.2.1 Electron Microscopic Identification 9 2.2.1.1 Scanning Electron Microscopy 9 2.2.1.2 Transmission Electron Microscopy 10 2.2.1.3 Atomic Force Microscopy 11 2.2.1.4 Cryo-Electron Microscopy 12 2.2.2 Particle Size Detection 13 2.2.2.1 Nanoparticle Tracking Analysis 13 2.2.2.2 Dynamic Light Scattering 14 2.2.3 Surface Protein Assay 16 2.2.3.1 Protein Immunoblotting Method 17 2.2.3.2 Nano-Flow Cytometry 19 2.2.3.3 Enzyme-Linked Immunosorbent Assay 19 2.2.4 Other Methods 21 2.2.4.1 Tunable Resistive Pulse Sensing 21 2.2.4.2 Single EV Analysis Technique 22 2.2.4.3 Micronuclear Magnetic Resonance 23 References 24 3 Therapeutic Potential of Extracellular Vesicles from Different Cell Sources 35 Xueyi Wang and Zhenhua li 3.1 Extracellular Vesicles Derived from Stem Cells (SCs) 35 3.1.1 Extracellular Vesicles Derived from Mesenchymal Stem Cells (MSCs) 37 3.1.1.1 Kidney Injury 38 3.1.1.2 Myocardial Ischemia/Reperfusion Injury (MI/RI) 38 3.1.1.3 Spinal Cord Injury (SCI) 39 3.1.1.4 Cancer 40 3.1.2 Extracellular Vesicles Derived from Neural Stem Cells (NSCs) 40 3.1.3 Extracellular Vesicles Derived from Endothelial Progenitor Cells (EPCs) 41 3.1.4 Extracellular Vesicles Derived from Cardiac Progenitor Cells (CPCs) and Other Stem Cells 41 3.2 Extracellular Vesicles Derived from Immune Cells 42 3.2.1 Extracellular Vesicles Derived from Macrophages 42 3.2.2 Extracellular Vesicles Derived from Dendritic Cells (DCs) 44 3.2.3 Extracellular Vesicles Derived from T Cells 45 3.2.4 Extracellular Vesicles Derived from Natural Killer (NK) Cells 46 3.3 Extracellular Vesicles Derived from Cancer Cells 47 3.4 Extracellular Vesicles Derived from Plants 49 3.4.1 Anti-inflammatory 49 3.4.2 Anticancer 50 3.4.3 Antibacterial 51 3.4.4 Antioxidation 51 References 51 4 Biomedical Applications of Extracellular Vesicles in Treatment of Disease 59 Fei Wang, Jiacong Ai, Ziyang Zhang, Yuanhang li, and Zhenhua li 4.1 Tissue Engineering and Regenerative Medicine 60 4.2 Metabolic Diseases 67 4.3 Cardiovascular Diseases 74 4.4 Respiratory Diseases 85 4.5 Cancers 88 4.6 Conclusion and Perspectives 93 References 94 5 Applications of Engineered Extracellular Vesicles 101 Lanya li, Yingxian Xiao, Shushan Mo, and Zhenhua li 5.1 Engineering EVs for Cargo Loading 101 5.1.1 Endogenous Loading 101 5.1.2 Exogenous Loading 104 5.2 Engineering EVs for Surface Modification 106 5.2.1 Genetic Engineering 106 5.2.2 Chemical Modification 108 5.2.3 Hydrophobic Membrane Engineering 109 References 111 6 Current Technology for Production, Isolation, and Quality Control of Extracellular Vesicles 117 Dandan Han, Yichuan Ma, Yujing Hu, and Zhenhua li 6.1 Production of EVs 117 6.1.1 Three-Dimensional Culture 117 6.1.2 Physical Stimulation 119 6.1.3 Chemical Stimulation 120 6.1.4 Physiological Modification 120 6.1.5 Genetic Manipulation 121 6.2 Extraction of EVs 122 6.2.1 Separation Strategies of EVs 123 6.2.2 Ultracentrifugation Approach 123 6.2.2.1 Differential Ultracentrifugation 123 6.2.2.2 Isopycnic and Moving-Zone Density Gradient Ultracentrifugation 125 6.2.3 Ultrafiltration Approach 125 6.2.4 Size-Exclusion Chromatography 127 6.2.5 Polymer Precipitation Strategy 128 6.2.6 Immunoaffinity Capture Approach 128 6.2.7 Microfluidic Technology 129 6.2.8 Other Methods 131 6.3 Quality Control of EVs 132 6.3.1 Transmission Electron Microscopy 133 6.3.2 High-Resolution Liquid Chromatography–Mass Spectrometry 134 6.3.3 Enzyme-Linked Immunosorbent Assay 134 6.3.4 Fourier-Transform Infrared Attenuated Total Reflection Spectroscopy 135 6.3.5 Capillary Electrophoresis 135 6.3.6 Nanoparticles Tracking Analysis 136 6.3.7 Flow Cytometer 137 6.3.8 Other Techniques 138 References 140 7 Prospects and Limitations of Clinical Application of Extracellular Vesicles 147 li Luo, Weirun li, and Zhenhua li 7.1 Application of Exosomes as Liquid Biopsy in Clinical Diagnosis 147 7.2 Exosomes—It has Become a Star Molecule in Disease Diagnosis 147 7.2.1 Exosomes Could Be Used as Prognostic and Diagnostic Biomarkers in Cancer 150 7.2.2 Exosomes Biopsy Strategies were Proposed to Target the Different Cancers 152 7.2.2.1 Pancreatic Cancer 152 7.2.2.2 Gastric Cancer 152 7.2.2.3 Lung Cancer 152 7.2.2.4 Breast Cancer 153 7.2.2.5 Liver Cancer 153 7.2.2.6 Ovarian Cancer 153 7.2.2.7 Melanoma 154 7.2.2.8 Colon Cancer 154 7.2.2.9 Glioma 155 7.2.3 Exosomes in Clinical Trial for Cancer Biopsy 155 7.3 The Commercial Application of Exosomes 158 7.3.1 Tumor Therapy 158 7.3.2 Lung Infection and ARDS Treatment 158 7.3.3 Cardiovascular Disease Treatment 160 7.3.4 Liver and Kidney Injury Treatment 160 7.3.5 Ophthalmology Treatment 160 7.3.6 Cartilage Injury Treatment 161 7.3.7 Other Treatments 161 7.3.8 Engineering of Exosome Delivery 161 7.3.9 Skin Repair and Medical Skincare Products 164 7.4 Commercial Development of Exosomes 166 7.4.1 Analysis of Representative Companies of Exosomes 168 7.4.1.1 ExoCoBio 168 7.4.1.2 Direct Biologics 168 7.4.1.3 Tianjin Exocrine Science and Technology 169 7.4.1.4 TheraXyte 170 7.4.1.5 Exosome Diagnostics 170 7.4.1.6 Codiak 171 7.4.1.7 Evox 171 7.4.1.8 EVerZom 171 7.5 Issues and Challenges 172 7.5.1 Quality Control 172 7.5.2 Storage Stability 172 7.5.3 Product Safety 173 7.5.4 Drug-Forming Properties of Engineered Exosomes 173 References 174 8 Conclusion and Future Perspectives 181 Xing-Jie liang, Ke Cheng, and Zhenhua li 8.1 Summary and Conclusions 181 8.2 General Trends and Developments 182 8.2.1 EVs in Drug Delivery 182 8.2.2 Engineered EVs in Biomedical Applications 183 8.2.3 EVs for Clinical Applications When Comparing with Liposomes 184 8.3 Challenges for Future Research 185 8.3.1 Standardization and Quality Control 185 8.3.2 Scalability and Manufacturing 185 8.3.3 Targeting and Biodistribution 186 8.3.4 Safety and Toxicity 186 8.3.5 Regulatory Challenges 186 8.3.6 Heterogeneity of EV Populations 187 8.3.7 Understanding the Role of EVs in Disease Progression and Development 187 Index 189
£106.25
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Stereochemistry - Workbook: 191 Problems and Solutions
Book SynopsisThis workbook in stereochemistry is designed for students, lecturers and scientists in chemistry, pharmacy, biology and medicine who deal with chiral chemical compounds and their properties. It serves as a supplement to textbooks and seminars and thus provides selected examples for students to practice the use of the conventions and terminology for the exact three-dimensional description of chemical compounds. It contains 191 problems with extended solutions. Trade ReviewThe late Edgar Heilbronner, one of the great physical and organic chemists of the 20th century, had a particularly effective lecture. He started it as follows: "You know pretty much everything I am going to say. So let us begin with the questions." And up on the screen flashed the first question. The lecture continued in the same vein; Heilbronner’s carefully structured answers to just the right questions led to a fascinating seminar, and a learning experience. I thought of Edgar Heilbronner’s lecture as I read the Hellwich and Siebert "Stereochemistry Workbook." In it are 191 graduated problems, along with succinct and clear solutions. One has to know a little stereochemical lore to begin with, for instance the priority rules of the CIP system. But otherwise everything is taught, in exemplary fashion, just through the progression of questions and answers. Complexities of naming coordination compounds, and dealing with chirality planes and axes are not avoided. The examples grow increasingly challenging. The success of this small volume lies in the fact it has a hidden narrative structure. Complexity is introduced in stages; solutions to the problems are attainable goals. One is drawn in, it is fun to go on. And the book is decorated with fascinating short stories of pharmaceutical design and utility. We have here a rare instance of a well-designed workbook that constructs a learning experience better than that found in most textbooks. What more would I want to see in it? The ordinary (of reasonable Lewis structures, normal bond lengths, moderate temperature [T less than ~100 °C]) which is the province of the beautiful compounds that are discussed in this book, needs to be defined. The ordinary is not diminished by what constrains it, for the fantastic variety the normal world generates suffices. But it is good to be aware of just what the assumptions are. Let me give an example. In one problem, a set of isomers of a bicyclic compound (cyclothiazide) is eliminated from discussion because a bridge can be formed only by cis fusion. In another example, two isomers of a [CoCl2(H2NNH2)(PPh3)2] complex are said to be not possible, those where the H2NNH2 would bridge trans-positions on the octahedral metal. Indeed, both statements make sense, but it would be interesting to mention why they are true (strain, the long N–N bond necessary). And how it is in the nature of chemists to subvert the impossible, and what ingenious molecules might do if there is no option but the energetically costly impossible. "Stereochemistry Workbook," one of the most effective pedagogical texts I’ve encountered, re-emphasizes the fundamental role of geometry in chemistry. Molecules have shapes. The logic of isomerism, in all its manifestations, the life-and-death-determining necessity of describing three-dimensional geometry, our representational struggles to do so – these define the beauty of chemistry. (Roald Hoffmann, Cornell University, Beilstein Journal of Organic Chemistry 2009, 5, No. 38)Table of ContentsQuestions.- Answers.
£29.69
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Colloid Chemistry II
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£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG New Aspects in Phosphorus Chemistry III
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£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Templates in Chemistry I
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£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Metathesis Polymerization
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£179.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Heterocyclic Antitumor Antibiotics
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£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG QSAR and Molecular Modeling Studies in Heterocyclic Drugs II
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£261.32
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocyles I
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Springer-Verlag Berlin and Heidelberg GmbH & Co. KG QSAR and Molecular Modeling Studies in Heterocyclic Drugs I
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Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Stereoselective Heterocyclic Synthesis III
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£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Flavours and Fragrances: Chemistry, Bioprocessing and Sustainability
Book SynopsisThis book is an introduction to the world of aroma chemicals, essential oils, fragrances and flavour compositions for the food, cosmetics and pharmaceutical industry. Present technology, the future use of resources and biotechnological approaches for the production of the respective chemical compounds are described. The book has an integrated and interdisciplinary approach on future industrial production and the issues related to this topic.Table of ContentsGüntert: The Flavour and Fragrance Industry – Past, Present and Future.- Müller: Flavours: The Legal Framework.- German: Olfaction, where Nutrition, Memory and Immunity Intersect.- Baser: Chemistry of Essential Oils.- Juliani: Bioactivity of Essential Oils and their Components.- Rouseff: Citrus Flavour.- Christensen: Fruits and Vegetables of Moderate Climate.- Pastore: Tropical Fruit Flavour.- Verpoorte: Vanilla.- Christoph and Christoph: Flavour of Spirit Drinks – Composed by Raw Materials, Fermentation, Distillation, and Ageing.- Fischer: Wine aroma.- Mottram: The Maillard Reaction: Source of Flavour in Thermally Processed Foods.- van der Schaft: Chemical Conversions of Natural Precursors.- Buckenhueskes: Industrial Quality Control.- Blank and Nitz: Advanced Instrumental Analysis & Electronic Noses.- Grosch: Gas Chromatography–Olfactometry (GCO) of Aroma Compounds.- Mosandl: Enantioselective and Isotope Analysis – Key Steps to Flavour Authentication.- Reineccius: Flavour Isolation Techniques.- Crespo: Aroma Recovery by Organophilic Pervaporation.- van Soest.- Encapsulation of Fragrances and Flavours: A Way to Control Odour and Aroma in Consumer Products.- Krammer: Creation and Production of Liquid and Dry Flavours.- Schreier: Enzymes and Flavour Biotechnology.- Schrader: Microbial Flavour Production.- Larroche: Microbial Processes.- Scragg: The Production of Flavours by Plant Cell Cultures.- Schwab: Genetic Engineering of Plants and Microbial Cells for Flavour Production
£132.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Heterocyclic Supramolecules I
a huge range and FREE tracked UK delivery on ALL orders.
£170.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Bioactive Heterocycles II
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£161.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Anthracycline Chemistry and Biology II: Mode of Action, Clinical Aspects and New Drugs
Book SynopsisThis series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.Table of ContentsG.L. Beretta, F. Zunino: Molecular Mechanisms of Anthracycline Activity.- P. Menna, E. Salvatorelli, L. Gianni, G. Minotti: Anthracycline Cardiotoxicity.- M.L. Capobianco, C.V. Catapano: Daunomycin-TFO Conjugates for Downregulation of Gene Expression.- F. Kratz: Acid-Sensitive Prodrugs of Doxorubicin.- J.-C. Florent, C. Monneret: Doxorubicin Conjugates for Selective Delivery to Tumors.- T.H. Koch, B.L. Barthel, B.T. Kalet, D.L. Rudnicki, G.C. Post, D.J. Burkhart: Anthracycline–Formaldehyde Conjugates and Their Targeted Prodrugs - F.-M. Arcamone: Sabarubicin.- M. Broggini: Nemorubicin
£179.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Synthesis of Heterocycles via Cycloadditions I
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£250.92
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Heterocyclic Supramolecules II
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£250.92
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Essentials of Biochemistry
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£44.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Beauty in Chemistry: Artistry in the Creation of New Molecules
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£170.99
