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Obelisco Manos Curativas
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Obelisco Cancer: Mas Alla de la Enfermedad
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Springer Oncothermia: Principles and Practices
Book SynopsisOncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co. Table of ContentsOBJECTIVE OF THE BOOK 1. ONCOLOGY – TREATMENTS AND THEIR LIMITS 1.1. CANCER – SHORT HISTORY AND EFFORTS TO CURE 1.1.1. Historical notes 1.1.2. The “war” against cancer 1.2. PARADIGM AND CHALLENGES OF ONCOTHERAPIES 1.3. LIMITATIONS OF ONCOTHERAPIES – QUEST FOR STEPS FORWARD 1.3.1. Medical challenge of oncotherapies 1.3.2. Ethical challenge of oncotherapies 1.3.3. Evaluation challenge of the results 2. HYPERTHERMIA RESULTS AND CHALLENGES 2.1. HYPERTHERMIA APPROACH 2.1.1. Definition of hyperthermia in oncology 2.1.2. Basic concepts of oncological hyperthermia 2.1.3. Technical variations of hyperthermia in oncology 2.2. EFFECTS OF HYPERTHERMIA 2.2.1. Higher baseline temperature 2.2.2. Vascular changes 2.2.3. Cellular membrane changes 2.2.4. Lactic acid formation 2.2.5. ATP depletion 2.2.6. Altered DNA replication 2.2.7. Enhanced immune reaction 2.2.8. Pain reduction 2.2.9. Selective gain of the heat-resistance 2.3. CLINICAL ONCOLOGICAL HYPERTHERMIA 2.3.1. Local and whole-body heating 2.3.2. Hyperthemia as a complementary method 2.4. HYPERTHERMIA SUCCESSES 2.4.1. Brain tumor treatments by hyperthermia 2.4.2. Pancreas tumor treatment by hyperthermia 2.4.3. Lung and bronchus 2.4.4. Hepatocellular carcinoma and metastatic tumors of liver 2.4.5. Colo-rectal tumors 2.4.6. Esophagus 2.4.7. Head and neck localizations 2.4.8. Gastric tumors 2.4.9. Breast tumors 2.4.10. Other localizations treated by hyperthermia 2.5. HYPERTHERMIA CHALLENGES IN ONCOLOGY 2.5.1. Challenge of selection and focus 2.5.2. Challenge of temperature 2.5.3. Medical challenges of hyperthermia in oncology 2.5.4. Challenge on quality control and dosimetry of hyperthermia 2.5.5. What we expect? 2.5.6. Possible solution: oncothermia 3. THERMO-BIO-PHYSICS 3.1. FACTORS OF PHYSIOLOGY HEATING 3.2. BIOTHERMODYNAMICS 3.2.1. Energy, heat and temperature 3.2.2. Energy of the chemical bonds and reactions 3.2.3. Energy sources and driving forces 3.2.4. Energy and structure 3.2.5. Energetics of malignant cells 3.2.6. “Non-thermal” effects – thermodynamial approach 3.3. BIOELECTRODYNAMICS 3.3.1. Basic interactions 3.3.2. The bioimpedance 3.3.3. “Nonthermal effects” – electrodynamical appraoch 3.3.4. “Non-thermal effects” – approach of electric currents 3.3.5. Membrane effects 3.3.6. Stochastic processes 3.3.7. Noises and signals 3.3.8. Resonances 3.3.9. Modulation-demodulation 3.3.10. Special field-effects of bio-systems 4. ONCOTHERMIA – NEW KIND OF ONCOLOGIC HYPERTHERMIA 4.1. ONCOTHERMIA CHARACTERISTICS 4.1.1. Electro Cancer Therapy (ECT) 4.1.2. Concept of oncothermia 4.1.3. Pennes equation revised 4.1.4. Thermal limit problem 4.1.5. Energy-transfer through the body surface 4.1.6. Penetration depth 4.1.7. Arrangement of electrodes 4.1.8. Far from equilibrium 4.1.9. Energy intake and temperature 4.1.10. Macroscopic focusing on the tumor 4.1.11. Heating the extracellular electrolyte 4.1.12. Temperature gradient and heat-flow on the membrane 4.1.13. Changes of the membrane potential 4.1.14. Membrane damage by constrained ion-currents 4.1.15. Effect on cell-cell connections 4.1.16. Oncotherm comparison 4.2. ONCOTHERMIA TREATMENT GUIDELINES 4.2.1. Treatment planning 4.2.2. Treatment consensus 4.3. COMPLEMENTARY APPLICATIONS 4.3.1. Complementary to radiotherapy 4.3.2. Complementary to chemotherapy 4.3.3. Clinical toxicity, safety 4.4. ONCOTHERMIA CASE REPORTS 4.4.1. Near eye treatments 4.4.2. Brain cases 4.4.3. Gynecology cases 4.4.4. Gastrointestinal cases 4.4.5. Pulmonary cases 4.4.6. Other cases 4.5. EVALUATION OF ONCOTHERMIA STUDIES 4.5.1. Evaluation conditions 4.5.2. Evaluation methods 4.6. GENERAL OVERVIEW ON A LARGE PATIENT’S POOL 4.7. BRAIN STUDIES 4.7.1. Brain safety study (Phase I) 4.7.2. Brain efficacy study (Phase II) 4.7.3. Hungarian brain glioma study 4.7.4. Small prospective, double arm brain glioma study 4.7.5. Study of brain gliomas with local clinical responses 4.7.6. Brain glioma study with relapses 4.7.7. Bicentral brain glioma study 4.7.8. Oncothermia for heavy pre-treated & relapsed brain gliomas 4.7.9. Study of metastatic brain tumors 4.7.10. Comparison of oncothermia brain studies 4.8. PANCREAS STUDIES 4.8.1. Pancreas efficacy study I. 4.8.2. Pancreas efficacy study II. (HTT) 4.8.3. Additional historical control to HTT pancreas study 4.8.4. Comparison of pancreas efficacy studies I. & II. 4.8.5. Pancreas efficacy study III. 4.8.6. Pancreas efficacy study IV. 4.8.7. Other oncothermia pancreas studies and their comparison 4.9. LUNG STUDIES 4.9.1. Oncothermia lung study I. 4.9.2. Oncothermia lung study II. 4.9.3. Meta-analysis of oncothermia lung studies 4.9.4. Compare to historical control 4.10. LIVER STUDIES 4.10.1. Study of liver metastases colorectal origine 4.10.2. Study of advanced liver metastases colorectal origine II. 4.10.3. Comparison study of treatment lines of colorectal liver metastases 4.10.4. Study of platinum derivatives with oncothermia for liver metastases from colorectal origine 4.10.5. Study of liver metastases rectal origine 4.10.6. Study of liver metastases various origine 4.10.7. Study of far advanced liver metastases various origines. Comparison of complementary therapies 4.11. COMPARISON OF STUDIES OF LIVER METASTASES 4.12. GYNECOLOGICAL (PELVIC) CANCER STUDY 4.12.1. Ovary study 4.12.2. Uterine corpus cancer 4.12.3. Uterine cervix 4.12.4. Comparison of oncothermia in pelvic gynecology 4.13. BREAST STUDY 4.14. ESOPHAGUS STUDY 4.14.1. Esophagus study I. 4.14.2. Esophagus study II. 4.15. STOMACH STUDY 4.16. COLO-RECTAL STUDIES 4.16.1. Preoperative oncothermia for rectum carcinoma 4.16.2. Colorectal carcinoma study 4.17. BONE STUDIES 4.17.1. Refractory bone metastases complementary to radiotherapy 4.17.2. Advanced bone metastases monotherapy 4.17.3. Osteosarcoma study 4.18. KIDNEY STUDY 4.19. HEAD AND NECK STUDY 4.20. URINARY BLADDER MALIGNANCIES 4.21. SOFT-TISSUE MALIGNANCIES 4.22. PROSTATE STUDY 4.23. ONCOTHERMIA PERSPECTIVES APPENDIX 1 ENTROPY AND TEMPERATURE APPENDIX 2 THERMODYNAMICS – ONSAGER’S RELATION APPENDIX 3 SELF-SIMILARITY AND BIOSCALING APPENDIX 4 ENERGY SUPPLY BY DEMANDS APPENDIX 5 ONCOGENIC GROWTH APPENDIX 6 BASIC BIOELECTROMAGNETICS APPENDIX 7 BIOIMPEDANCE OF CELLS & TISSUES APPENDIX 8 BOUNDARY CONDITIONS APPENDIX 9 DIRECT CURRENT APPLICATIONS APPENDIX 10 DEVELOPMENT OF EDEMA APPENDIX 11 WARBURG-IMPEDANCE APPENDIX 12 CELL-MEMBRANE PERMEABILITY APPENDIX 13 STOCHASTIC PROCESSES – PINK-NOISE APPENDIX 14 AUTOCORRELATION APPENDIX 15 DISSIPATIVE SYSTEMS APPENDIX 16 STOCHASTIC RESONANCE APPENDIX 17 RESONANCE OF ENZYMATIC REACTIONS APPENDIX 18 DEMODULATION BY STOCHASTIC RESONANCE APPENDIX 19 NON-LINEAR EFFECTS OF ENERGY-FLOW APPENDIX 20 PRINCIPLE OF MINIMAL ENERGY-DISPERSION APPENDIX 21 CHARGE-INHOMOGENETIES APPENDIX 22 PENNES’ EQUATION APPENDIX 23 PENNES’ EQUATION IS REVISED APPENDIX 24 SELF-FOCUSING APPENDIX 25 DYNAMISM OF TEMPERATURE ON THE MEMBRANE APPENDIX 26 CHANGES OF THE MEMBRANE-POTENTIAL APPENDIX 27 MEMBRANE DAMAGE BY INCREASING PRESSURE APPENDIX 28 DYNAMICS OF ADHERENT BONDS APPENDIX 29 MODULATION EFFECT APPENDIX 30 COMPONENTS OF CELL-DESTRUCTION APPENDIX 31 EXPERIMENTAL CONDITIONS IN VITRO APPENDIX 32 EXPERIMENTAL CONDITIONS IN VIVO APPENDIX 33 CONSIDERATIONS FOR EXPERIMENTAL SETUP IN VIVO APPENDIX 34 VALIDATION OF MORPHOLOGIC EVALUATION APPENDIX 35 EVALUATION OF SURVIVAL STUDY WITH SINGLE ARM 5. ACKNOWLEDGEMENT 6. REFERENCES
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Taylor & Francis Ltd Advanced Skin Cancer
Book SynopsisAdvanced skin cancer is one that has already metastasized beyond its primary origin, or one that has invaded underlying tissues such that surgical resection either is technically impossible or would lead to an unacceptable functional or cosmetic outcome. These skin cancers present a complex problem that requires the input of multiple specialties to delineate the best management plan. National guidelines utilize the best available data to guide management decisions. However, there is considerable leeway within the guidelines, enabling the ultimate care decision to be molded to best fit each individual patient. This book aims to provide instructional examples of patient cases where the input of the multidisciplinary team is critical in providing the most suitable care plan for the patient.CONTENTS: Melanoma * Squamous Cell Carcinoma * Basal Cell Carcinoma * Cutaneous Lymphoma * Kaposi's Sarcoma * Dermatofibrosarcoma Protuberans * Merkel Cell Carcinoma * Rare CaTrade Review"...provides an understanding of the depth of decision-making involved by multiple specialists in the field".- Doody's ReviewTable of ContentsMelanoma * Squamous Cell Carcinoma * Basal Cell Carcinoma * Cutaneous Lymphoma * Kaposi’s Sarcoma * Dermatofibrosarcoma Protuberans * Merkel Cell Carcinoma * Rare Cancer Presentations
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Taylor & Francis Ltd Macrophages Cancer Routledge Revivals
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Taylor & Francis Ltd Understanding Radiation Biology From DNA Damage to Cancer and Radiation Risk
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Taylor & Francis Ltd Understanding Radiation Biology From DNA Damage
Book SynopsisThis book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the doseeffect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and Trade Review“This is a textbook on the understanding of radiation biology, which covers the basic principles governing the action of radiation on living matter. The book is well organized and easy to read. It is designed as an alternative or even complementary to other established books in the fields of radiation biology, radiotherapy, and radiological protection. Moreover, the plethora of mathematical formulas provided makes it easy to translate the presented theoretical concepts into practical tools in the clinic. The contents of the book correlate well with the required topics in preparation for the American Board of Radiology (ABR) board examinations.The most common aspects of radiation biology have successfully been addressed and presented in a way that satisfies the educational and practical goals of the book. The findings of more recent studies have been included. The book also expands to new fields such as ultraviolet light and genotoxicology. The book covers all the necessary theory, examples, and formulas that are useful to radiation biologists, radiation oncology physicians, and medical physicists (professionals and residents). The reference list at the end of the book is a great resource for individuals who want to further expand their literature investigation. This book is primarily designed to cover the needs of radiation biologists, radiation oncology physicians, and medical physicists. It can also be a useful reference for medical dosimetrists and therapy technologists. For faculty and established practitioners, it can serve as a great supplemental resource for dealing with radiation biology problems in the classroom or clinic.The book presents a coherent, quantitative, and qualitative theory of radiation biology, which has been developed and expanded over the years from the 1970s to present. It follows a practical approach providing the mathematical formulas that would allow for an intuitive implementation of the theoretical concepts in the clinic. It can help biologists and radiation oncology and medical physics residents build their background knowledge and understanding of why and how things happen in the clinical environment. Furthermore, it can serve as a quick and comprehensive review of the basic principles and concepts in the field of radiation biology. I recommend this textbook as a teaching tool for biology and medical physics training programs as well as for radiation oncology and medical physics residency programs.”—Panayiotis Mavroidis, PhD (University of North Carolina at Chapel Hill) in Doody’s Core Titles Review 2022.Table of ContentsPART I: Ionising Radiation Effects. 1. The Molecular Model and DNA Double Strand Breaks. 2. The Molecular Model for Cellular Effects. 3. The Link from Molecular Lesion to Cellular Effects. 4. DNA Double Strand Breaks and Chromosomal Aberrations. 5. The Effect of Dose Rate, Fractionation and Post-Irradiation Repair. 6. Radiation Quality. 7. Radiation-Induced Cancer. 8. Radiation-Induced Lethality. 9 Radiological Protection. PART II: Ultraviolet Light Effects. 10. The Molecular Model for the Cytotoxic Action of UV Light. PART III: Genotoxicology. 11. An Assessment of the Risk of Chemical Mutagens.
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Taylor & Francis Ltd AutoSegmentation for Radiation Oncology
Book SynopsisThis book provides a comprehensive introduction to current state-of-the-art auto-segmentation approaches used in radiation oncology for auto-delineation of organs-of-risk for thoracic radiation treatment planning. Containing the latest, cutting edge technologies and treatments, it explores deep-learning methods, multi-atlas-based methods, and model-based methods that are currently being developed for clinical radiation oncology applications. Each chapter focuses on a specific aspect of algorithm choices and discusses the impact of the different algorithm modules to the algorithm performance as well as the implementation issues for clinical use (including data curation challenges and auto-contour evaluations). This book is an ideal guide for radiation oncology centers looking to learn more about potential auto-segmentation tools for their clinic in addition to medical physicists commissioning auto-segmentation for clinical use. Features: Up-to-date Trade Review"This textbook provides a comprehensive overview of multi-atlas and deep learning approaches to auto-contouring. Furthermore, key questions on clinical implementation are considered. The first introductory chapter describes the main focus of this book being the Thoracic Auto-segmentation Challenge held as an event of the 2017 Annual Meeting of the American Association of Physicists in Medicine (AAPM). Several challenge participants contributed a chapter to this book, addressing a specific strength of their segmentation algorithms. The lack of broad clinical introduction of auto-segmentation, which according to the editors is partly due to the lack of commissioning guidelines, made them dedicate the third part of the book to clinical implementation concerns. The book is written for everyone working in the field of auto-segmentation in radiotherapy. The experienced editors are from academia, clinical physics, and industry; their broad experience gives excellent perspective to this book…This book was useful toward improving my understanding of deep learning-based methods in medical image segmentation. To the best of my knowledge, this is the only textbook available on auto-segmentation dedicated to radiation oncology. Practical concerns and recommendations for implementation make this textbook a must-have for every radiation oncology department." — Charlotte Brouwer, M.Sc. in Medical Physics (December, 2021) Table of ContentsContents Foreword I..........................................................................................................................................ix Foreword II........................................................................................................................................xi Editors............................................................................................................................................. xiii Contributors......................................................................................................................................xv Chapter 1 Introduction to Auto-Segmentation in Radiation Oncology.........................................1 Jinzhong Yang, Gregory C. Sharp, and Mark J. Gooding Part I Multi-Atlas for Auto-Segmentation Chapter 2 Introduction to Multi-Atlas Auto-Segmentation......................................................... 13 Gregory C. Sharp Chapter 3 Evaluation of Atlas Selection: How Close Are We to Optimal Selection?................. 19 Mark J. Gooding Chapter 4 Deformable Registration Choices for Multi-Atlas Segmentation............................... 39 Keyur Shah, James Shackleford, Nagarajan Kandasamy, and Gregory C. Sharp Chapter 5 Evaluation of a Multi-Atlas Segmentation System......................................................49 Raymond Fang, Laurence Court, and Jinzhong Yang Part II Deep Learning for Auto-Segmentation Chapter 6 Introduction to Deep Learning-Based Auto-Contouring for Radiotherapy................ 71 Mark J. Gooding Chapter 7 Deep Learning Architecture Design for Multi-Organ Segmentation......................... 81 Yang Lei, Yabo Fu, Tonghe Wang, Richard L.J. Qiu, Walter J. Curran, Tian Liu, and Xiaofeng Yang Chapter 8 Comparison of 2D and 3D U-Nets for Organ Segmentation.................................... 113 Dongdong Gu and Zhong Xue Chapter 9 Organ-Specific Segmentation Versus Multi-Class Segmentation Using U-Net....... 125 Xue Feng and Quan Chen Chapter 10 Effect of Loss Functions in Deep Learning-Based Segmentation............................ 133 Evan Porter, David Solis, Payton Bruckmeier, Zaid A. Siddiqui, Leonid Zamdborg, and Thomas Guerrero Chapter 11 Data Augmentation for Training Deep Neural Networks ........................................ 151 Zhao Peng, Jieping Zhou, Xi Fang, Pingkun Yan, Hongming Shan, Ge Wang, X. George Xu, and Xi Pei Chapter 12 Identifying Possible Scenarios Where a Deep Learning Auto-Segmentation Model Could Fail...................................................................................................... 165 Carlos E. Cardenas Part III Clinical Implementation Concerns Chapter 13 Clinical Commissioning Guidelines......................................................................... 189 Harini Veeraraghavan Chapter 14 Data Curation Challenges for Artificial Intelligence................................................ 201 Ken Chang, Mishka Gidwani, Jay B. Patel, Matthew D. Li, and Jayashree Kalpathy-Cramer Chapter 15 On the Evaluation of Auto-Contouring in Radiotherapy.......................................... 217 Mark J. Gooding Index............................................................................................................................................... 253
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Taylor & Francis Ltd Radiomics and Radiogenomics
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Taylor & Francis Ltd Monte Carlo in Heavy Charged Particle Therapy
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Taylor & Francis Ltd An Introduction to PsychoOncology
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