Oncology Books

Book SynopsisPar-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.Table of ContentsIntroductionChapter 1. Discovery and Overview of Par-4Chapter 2. Significance of Par-4 Interaction with aPKCChapter 3. Structural Analysis of the C-terminal domain of Par-4Chapter 4. Crystallization and crystallographic analysis of the C-terminal domain of Par-4 (PAWR)Chapter 5. Role of ubiquitinase FBX045 in Par-4 regulationChapter 6. Regulation of Par-4 by type II phosphatidylinositol 4-kinase βChapter 7. Role of Par-4 in regulation of cell death by circumin and ceramideChapter 8. Par-4 in dissociation induced cell death in human pluripotent stem cellsChapter 9. Role of Par-4 in EMTChapter 10. Bacillus thuringiensis Induced Par-4 and Apoptosis in Human CellsChapter 11. Role of Par-4 in ZebrafishChapter 12. Role of Par-4 in GRP78 translocationChapter 13. Interaction of THAP1 with Par-4 in PML bodiesChapter 14. Regulation of DAPK and AMIDA by Par-4Chapter 15. Regulation of Par-4 by CK2 kinase

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Book SynopsisChondrosarcoma, a rare cancer that develops from cartilage cells, occurs mainly in the bones but can also appear in the soft tissue of the pelvis, hip and shoulder. Unfortunately, these cancers are highly resistant to both chemotherapy and radiation, and no successful adjuvant therapies currently exist. As such, surgical treatment and resection remain the mainstays of management for patients with these tumors. This concise text is a comprehensive presentation of the current knowledge regarding the development, diagnosis and management of chondrosarcomas. Part I discusses pathology, molecular biology and imaging features of chondrosarcomas. The different types of skeletal and extraskeletal tumors are presented in detail in part II, including conventional and secondary tumors. Management approaches are outlined and described in part III - limb salvage surgery is the most common, and although less effective, radiation and chemotherapy are indicated in certain cases. Part IV examines the future of chondrosarcoma management and development of novel adjuvant therapies, as well as the relationship of this disease to similar types (e.g., chordoma). Bringing together the most up-to-date information on this rare cancer, Chondrosarcoma will be a valuable resource for orthopedic oncologists, researchers and all medical professionals treating these challenging tumors. Table of ContentsPart I Biology of Chondrosarcoma 1 Pathology of Chondrosarcoma 2 Advances in the Molecular Biology of Chondrosarcoma 3 Imaging Features of Chondrosarcoma Part II 4 Chondrosarcomas: Conventional and Secondary 5 Primary Soft Tissue Chondrosarcoma Part III Management of Chondrosarcoma 6 Chondrosarcoma of the Axial Skeleton 7 Chondrosarcoma of the Appendicular Skeleton 8 Chondrosarcoma of the Hand 9 Chondrosarcoma of the Clavicle 10 Radiation Therapy for Chondrosarcoma 11 Systemic Therapy for Chondrosarcoma 12 Vascular Issues in Complex Surgical Resection of Chondrosarcoma Part IV The Future of Chondrosarcoma Research and Treatment 13 The Future of Chondrosarcoma Research and Treatment

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Book SynopsisThis book provides a comprehensive review of the epidemiology, pathogenesis, diagnosis, and management of chordomas of the mobile spine and sacrum. Historically, knowledge about how to deliver such state-of-the-art care has not been widespread, resulting in inconsistent treatment, and, all too often, suboptimal outcomes for chordoma patients. This text is an important step towards broadening that knowledge, and, in turn, improving the care provided to chordoma patients. The book is divided into 4 parts comprising 16 chapters. The first part focuses on the pathophysiology and molecular drivers of chordoma. The second focuses on the epidemiology and clinical history, as well as the histological, oncologic, and radiographic work-up of chordoma. The third part focuses primarily on the technical aspects of surgery for chordoma. It is broken down by anatomic region, with the final two chapters focusing on the soft tissue and bony reconstruction following chordoma resection. The last part focuses on the exciting field of adjuvant therapies for chordoma. This includes both radiation therapies and novel chemotherapeutic options for recurrent, metastatic, and dedifferentiated chordoma. Written by world experts from leading chordoma centers, Chordoma of the Spine serves as a valuable reference for spinal oncologists and general spine surgeons who may encounter chordoma patients in their practice. It provides the most up-to-date evidence regarding all aspects of treating patients with this disease. By focusing on this specific pathology of the spine, this resource condenses expert-level research into understandable treatment algorithms.Table of ContentsSection I Pathophysiology and Molecular Mechanisms of Chordoma1 Notochordal Morphogenesis and the Origin of Chordoma Matthew L. Goodwin, MD PhD, David C. Clever, MD PhD2 Molecular and Genetic Mechanisms of Spinal ChordomaConnor Liu, BS; Ann Liu, MD; Chetan Bettegowda, MD/PhDSection II Epidemiology, Clinical History, and Work-Up for Chordoma3 Historical Overview, Demographics, and Clinical Presentation of Spinal Chordoma Zach Pennington BS, Andrew Schilling AB, Joseph H. Schwab MS MS, Daniel M. Sciubba MD4 Clinical Work up, Diagnostic Imaging and Biopsy Daniel Ryan, MD; John Gross, MD; Zach Pennington BS, Majid Khan, MD5 Histopathologic Classification of Spinal Chordoma John M Gross MD, Edward F McCarthy MD6 Multi-disciplinary Planning for Treatment Nicholas A Shepard MD, Matthew W Colman MDSection III Surgical Management of Chordoma7 Surgical Management of Chordoma of the Occipitocervical Junction Zach Pennington BS, Jeff Ehresman BS, Andrew Schilling BA, Daniel M. Sciubba MD8 Surgical Management of Chordoma of the Cervical Spine Oliver G.S. Ayling MD, MSc, Nicolas Dea MD, MSc9 Surgical Management of Chordoma of the Thoracic Spine Daniel G. Tobert MD, John H. Shin MD, Joseph H. Schwab MD10 Surgical Management of Chordoma of the Lumbar Spine Sutipat Pairojboriboon MD, Amanda Sacino MDPhD, Sheng-fu Larry Lo MD11 Surgical Management of Chordoma of the Sacrum Peter S. Rose, MD, Matthew T. Houdek, MD, Cory G. Couch, MD12 Soft Tissue Reconstruction Following Surgery for Sacral Chordoma Rachel Skladman MD, Zach Pennington BS, Justin M. Sacks MD MBA FACS13 Vascular Reconstruction After EnBloc Resection. Daniel G. Tobert MD, Joseph H. Schwab MDSection IV Radiation and Chemotherapeutic Adjuvants for Chordoma14 Photon Therapy for Chordoma of the Spine Chunzi Jenny Jin MD MSc, Yoshiya Josh Yamada MD FRCPC15 Heavy Particle Therapy for Chordoma David J. Konieczkowski MD PhD, Reiko Imai MD, Thomas F. DeLaney MD16 Systemic Therapy, Trials and Future Directions for Chordoma of the Spine Daniel J. Zabransky, MD, PhD, Zach Pennington BS, Christian Meyer, MD, MS, PhDIndex

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Book SynopsisThis book provides a comprehensive examination of uveal melanoma, a rare neoplasm that carries a very high mortality and whose natural history makes it fairly unique among adult tumors. Split into three sections, this book explores the basic science behind the disease and inherited genetic syndromes that predispose some patients, as well as the pathology and use of gene expression profiling to determine risk of recurrence. It also focuses on the management of the primary tumor in the eye, including surgical intervention and lesion imaging. Elucidating treatment options for metastatic disease, the book reviews chemotherapy agents and immunotherapy approaches, as well as liver-directed therapies, cellular therapies, and various treatments after primary treatment but before the development of metastases.Uveal Melanoma: Biology and Management is the most up-to-date and comprehensive text devoted solely to this disease and will be useful to medical oncologists, ophthalmologists, radiation therapists, interventional radiologists, pathologists, molecular biologists and immunology researchers, as well as trainees in those fields.Table of ContentsMolecular Basis of Uveal Melanoma and Emerging Therapeutic Targets.- Clinical/Commercial.- Genetic Testing in UM.- BAP1 Tumor Predisposition Syndrome.- Pathology of Uveal Melanoma.- Epidemiology of Uveal Melanoma and Potential Clusters.- Gene Expression Profiling in the Management of Uveal Melanoma.- Surgical Considerations of Radiation Plaques and Enucleation.- Uveal Melanoma: Imaging.- Radiation Therapy in Ocular Melanoma.- Late Complications of Radiation Therapy in Uveal Melanoma.- Nanoparticles for the Treatment of Uveal Melanoma.- Screening Schedules for Metastatic Disease.- Adjuvant Therapy of Uveal Melanoma Liver-Directed Therapies for Hepatic Metastases.- Systemic Therapy for Metastatic Uveal Melanoma.- Cell Therapy for Uveal Melanoma.

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Book SynopsisPar-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.Table of ContentsIntroductionPart 1Chapter 1. Role of Par-4 in lung cancerChapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinomaChapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancersChapter 4. Regulation of Par-4 and role in GI tumorsChapter 5. Role of Par-4 in prostate cancerChapter 6. Activation of apoptosis by Par-4 in pancreatic cancerChapter 7. Role of Par-4 and GRP78 in GlioblastomaChapter 8. Role of Par-4 in breast cancer recurrenceChapter 9. Involvement of Par-4 in breast cancerChapter 10. Role of endogenous Par-4 in CLLChapter 11. Role of Par-4 in inhibition of TCL1 induced growthChapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cellsChapter 13. Par-4 expression in cholangiocarcinomaChapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cellsChapter 15. PAWR as direct SRC-1/HOXC11 suppression targetChapter 16. Par-4 cleavage is required for TNF induced apoptosisChapter 17. Par-4 secretagoguesChapter 18. Recombinant production and characterization of SACChapter 19. Anti-tumor effects of plant derived Par-4Chapter 20. Par-4 in Mycobacterium tuberculosis Infected MacrophagesPart 2 - Role in other DiseasesChapter 21. Role of Par-4 in ceramide inducible effects in neuronsChapter 22. Role of Par-4 in Alzheimers diseaseChapter 23. Dopamine signaling in association with induction of Par-4 protein expressionChapter 24. Par-4 (PAWR) in major depressive disorderChapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetesChapter 26. Par-4 in cardiac fibroblast senescenceChapter 27. Par-4 in ocular development and diseaseChapter 28. Par-4 in apoptosis during human salivary gland developmentChapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosisChapter 30. Lessons from knockout micePart 3 - From Bench to BedsideChapter 31. Par-4 secretagogues in clinical trialsChapter 32. Potential of Par-4 as a therapeutic target for cancer

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Book SynopsisThis book provides how-to recommendations and detailed guides for using transradial access in interventional radiology. A relatively new and growing technique, transradial access is most commonly found within interventional cardiology. This book approaches those cardiac uses of transradial access while extending its use to other body sites and disease states. The book details the interventional radiologist’s transition to using transradial access across a broad spectrum of clinical applications, allowing them to better introduce it into their practice and to their patients. The text is divided into three sections: overview, clinical applications, and novel applications and techniques. The first section covers the history of transradial access, the initial patient assessment, and how to prepare for a procedure. The second section is divided into different diseases and interventional situations where transradial access could be considered, including subclavian artery stenosis and endovascular neurosurgery. The third section includes coverage of how to perform the latest techniques and projections for future procedures. This guide provides a manual of operations to assist in the setup of the practice, from office visit to procedure room to recovery across a variety of service lines and patient populations. Key take home points and equipment summaries accompany each chapter, allowing the user to easily navigate the book to accelerate his or her practice. This is an ideal guide for interventional radiologists. Table of ContentsTransradial Access in Interventional Radiology: Background, Applications and Techniques 1. The Advent of Transradial Interventions: An Overview 2. Anatomy and Physical Exam 3. Nursing Assessment 4. Procedure Suite Set-Up 5. Recovery Room and Post Procedure Care 6. Access Complications and Management 7. Transradial Access for Renal and Mesenteric Artery Disease 8. Transradial Access for Interventional Oncology: Chemoembolization and Radioembolization Applications 9. Transradial Access for Peripheral Arterial Disease: Aortoiliac Applications 10. Transradial Access for Peripheral Arterial Disease: Infrainguinal Applications 11. Aortic Endoleak following Endovascular Aortic Repair 12. Transradial Access for Peripheral Arterial Disease: Subclavian and Upper Arm Interventions 13. Transradial Access in Uterine Artery Embolization 14. Prostate Artery Embolization 15. Hemodialysis Access Interventions 16. Carotid and Vertebral Intervention 17. Endovascular Neurosurgery and Stroke Intervention 18. Acute Hemorrhage and Trauma 19. Transulnar Arterial Access 20. Distal Transradial Arterial Access 21. Transradial Access for Bariatric Embolization

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Book SynopsisOver the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.Table of Contents1. Inflammatory components of the thyroid cancer microenvironment - an avenue for identification of novel biomarkers2. Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity3. Exosomes in the Healthy and Malignant Bone Marrow Microenvironment4. Structural Biology of the Tumor Microenvironment5. Metabolic interactions between tumor and stromal cells in the Tumor Microenvironment6. Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy7. Non-coding RNAs in Papillary Thyroid Cancer: Interaction with cancer associated fibroblasts (CAFs) in the Tumor Microenvironment (TME) and regulators of differentiation and Lymph Node Metastasis

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Book SynopsisWith the start of 2020, the wrath of pandemic challenged the scientific community to develop more advanced drug delivery approaches for biomedical applications, endowing conventional drugs with additional therapeutic benefits and minimum side effects. Although significant advancements have been done in the field of drug delivery, there is a need to focus towards strategizing novel and improved drug delivery systems that should be convenient and cost-effective to the patients, and simultaneously they should also provide financial benefits to pharmaceutical companies. Controlled drug delivery technology offers ample opportunities and scope for improvising the therapeutic efficacy of drugs via optimizing the drug release rate and time. For this endeavour, smart nanomaterials have served as remarkable candidates for biomedical applications, owing to their ground-breaking properties and design. The development of such nanomaterials requires a broad knowledge related to their physio-chemical properties, molecular structure, mechanisms by which the nanomaterials interact with the cells, and methods by which drugs are released at the site of action. This knowledge must also be allied with the knowledge of signaling crosstalk mechanisms that are modulated by the nanomaterial-drugs composite. It can be anticipated that these emerging drug delivery technologies can facilitate the world to successfully encounter such pandemic outbursts in the future in a cost-effective and time-effective manner. The chapters in this book deal with the advanced technologies and approaches that can benefit advanced students, researchers, and industry experts in developing smart and intelligent nanomaterials for future biomedical applications, and development, manufacturing, and commercialization for controlled and targeted drug delivery.Table of ContentsFOREWORDProf. G. VeerabhadramPREFACEChapter 1: Introduction to active smart nanomaterials for biomedical applicationsJin-Chul KimKangwon National University, Chuncheon, South Korea Chapter 2: Cancer cell sensing and therapy using affinity tag-conjugated gold nanoparticlesAlle MadhusudhanKangwon National University, Chuncheon, South Korea Chapter 3: Gold nanoparticles enlighten the future of cancer theranosticsJianfeng GuoSchool of Pharmaceutical Sciences, Jilin University, 1266, Fujin Road, Changchun 130021, ChinaChapter 4: Recent advances in hydrogels smart drug delivery systems Sharif AhmadDepartment of Pharmacology, All India Institute of Medical Sciences, India Chapter 5: Carbon-based nanomaterials for biomedical applicationsKai YangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China Chapter 6: A new era of cancer treatment: carbon nanotubes as drug delivery toolsAlexander M SeifalianCentre for Nanotechnology and Regenerative Medicine, University, College London, London, UK Chapter 7: pH- and ion-sensitive materials for control drug delivery Takayuki YoshidaDrug Delivery, Pharmaceutical Research and Technology Labs, Astellas Pharma, Inc., 180 Ozumi, Yaizu, Shizuoka 425-0072, JapanChapter 8: Thermo-responsive polymers and their application as smart biomaterialsYukiko T. MatsunagaCenter for International Research on Integrative Biomedical Systems (CIBiS), The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, JapanChapter 9: Redox-responsive polymers and their application in drug delivery systemsJohn F. QuinnARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Melbourne, Victoria 3052, AustraliaChapter 10: Recent strategies to explore the biomedical applications of nanocelluloseDinesh KumarKangwon National University, Chuncheon, South Korea Chapter 11: Tissue engineering using cellulose nanofibrils as Scaffold MaterialAndrew E. PellingSymbioticA, School of Human Sciences, University of Western Australia, Perth, WA, AustraliaChapter 12: Use of solid lipid nanoparticles to improve the oral bioavailability of poor soluble drugsDeepti PanditaDepartment of Pharmaceutics, Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa 125055, Haryana, IndiaChapter 13: Applications of dendrimers in drug delivery systemsE. BustosCentro de Investigacion y Desarrollo Tecnol ´ ogico en Electroqu ´ ´ımica S.C., Parque Tecnologico Quer ´ etaro s/n, Sanfandila, 76703 Pedro Escobedo, QRO, MexicoChapter 14: Liposomes for drug delivery: progress and problemsJin-Chul KimKangwon national University, Chuncheon, South KoreaChapter 15: Cubosome nanoparticles for enhanced delivery of anticancer drugJana B. NiederDepartment of Nanophotonics, Ultrafast Bio- and Nanophotonics Group, INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, PortugalChapter 16: Layer‐by‐Layer assemblies for cancer diagnosis and treatment UMR CNRS/INPG 5628 (LMGP), 3 parvis Louis Néel, 38016 Grenoble, FranceChapter 17: Polymeric micelles for drug deliveryAfsanesh Lavasanifar University of Albert, Edmonton, Alberta T6G2N8, CanadaChapter 18: Role of plant-based materials/gums in developing drug delivery systems B. Sashidhar Rao Department of Biochemistry, Osmania University, Hyderabad, IndiaChapter 19: Ethosomes: A novel tool for drug delivery through the skinAmarachinta Padmanabha RaoChapter 20: Niosomes as nanoparticular drug carriers: fundamentals and recent applicationsNoufel SamedChapter 21: Graphene oxide nanosheets used in photothermal therapyHongjie Dai Department of Chemistry, Stanford University, Stanford, California 94305, United States Chapter 22: Metal doped carbon dots used in bio-imaging and cancer therapyJoydeep DasSchool of Chemistry, Shoolini University of Biotechnology and Management Sciences, Bajhol, PO Sultanpur, Solan, HP, 173229, IndiaBIBLIOGRAPHYGLOSSARYINDEX

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Book SynopsisRenal Cancer: Current Status and Innovations provides a useful guide to the fundamental basics and latest diagnostic and treatment techniques for Renal Cancer. It features clearly structured and easy-to-understand chapters enabling the reader to develop a thorough understanding of screening, surveillance, diagnostics, pathology, robotic and open surgical approaches, ablation, medical treatment, psychology, and future innovations. The book provides a valuable resource for the full spectrum of clinicians involved in the multidisciplinary management of Renal Cancer.Table of ContentsIntroduction to the Multidisciplinary approach to Renal Cancer.- Imaging in Renal Cancer.- Application of Simulation Techniques.- Cognitive Simulation & Non technical skills training.- Team training.- Active surveillance and Percutaneous Treatment.- Endoscopic Surgery.- Laparoscopic Renal Surgery.- Robotic Surgery.- Focal Therapies.- Pre and Post-surgery, treatments.- Big Data and Renal Outcomes.- Future perspectives.

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Book SynopsisThis book provides a reference and contextual basis for depression, burnout and suicide among oncology and other medical professionals. Oncology as a medical subspecialty is at a unique apex of this crisis. While the same pressures in medicine certainly apply to oncologists, oncology is particularly stressful as a changing field with diverse patient and societal expectations for outcomes. In addition to experiencing the stress of caring for patients that could succumb to their cancer diagnoses, these professionals are regularly confronted with an onslaught of new medical information and a landscape that is changing at a breakneck pace. These are just a few factors involved in the increasing rates of burnout among oncologists as well as other medcial professionals. By addressing a gap in identifying mental health problems among health care professionals, this book sheds light on mental health problems and suicide among physicians. Importantly, this book is a call to action of the professional and administrative organizations to work on improving mental health of physicians. Anxiety and depression affect not only the individual doctor but also patient care. Given the increasing attention to these issues along with limited yet applicable data regarding how to address these issues, the text aims to bring the latest data face to face with consensus opinion and can be used to ultimately enhance oncologic and psychiatric practices. Written by experts in the field, Depression, Burnout and Suicide in Physicians: Insights from Oncology and Other Medical Professions aims to significantly increase awareness and contribute to understanding the necessity of preventive measures on individual, family, and care givers levels.Table of Contents1 The problem of Burnout, Depression, and Suicide in Physicians. A general overview 2 Medical Professionalism and Physician Dignity: Are we at risk of losing it? 3 Burnout in Medicine 4 Depression and substance use disorders in physicians. 5 Suicide and suicide risk in physicians 6 Screening and Assessment of Burnout With a Focus on Oncology Healthcare Providers 7 The Ethical Implications of Burnout: A Moral Imperative to Prioritize Physician Well-Being, Resilience, and Professional Fulfillment 8 Euthanasia and Medical Assistance in Dying as challenges for physicians’ well-being 9 Moral Distress in Physicians 10 Embitterment in the workplace 11 Prevention of burnout through resilience, wellness programs, and civility in the work environment 12 Cultivating Resilience and Preventing Burn Out: A Mindful Multi-Pronged Intervention Approach

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Book SynopsisThis book addresses the unmet needs of the medical community in dealing with the psychological problems, particularly anxiety and depression, of patients diagnosed with cancer. Providing a scholarly review of the impact of cancer diagnosis on patients’ emotional and psychological status, as well as the evidence that psychological factors impact cancer occurrence and biological behavior, this book explores the therapeutic implications of such converse dynamics. Chapters review financial toxicity, eHealth, palliative care, mindfulness, sleep and cancer, social support and cancer, cultural diversity, pediatric and adolescent oncology, and geriatric oncology. While intended primarily for the professional readership of oncologists, psychologists, psychiatrists, social workers, and palliative care physicians, a final chapter also provides practical information on available resources for patients. This fully updated and expanded new edition of Psychological Aspects of Cancer: A Guide to Emotional and Psychological Consequences of Cancer, Their Causes, and Their Management provides practitioners with cutting edge knowledge as well as practical information that translates into better care for patients with cancer. Table of ContentsInflammation, Chronic Disease, and Cancer: Is Psychological Distress the Common Thread?.- Psychological Factors and Survivorship: A Focus on Post-Treatment Cancer Survivors.- Couple Relationships and Cancer.- The Impact of Cancer and Its Therapies on Body Image and Sexuality.- Use of the Classic Hallucinogen Psilocybin for Treatment of Existential Distress Associated with Cancer.- Meaning, Spirituality, and Perceived Growth Across the Cancer Continuum: A Positive Psychology Perspective.- Stress, Coping, and Hope.- Religiousness and Spirituality in Coping with Cancer.- Psychoneuroimmunology and Cancer: Mechanisms Explaining Incidence, Progression, and Quality of Life Difficulties.- Psychosocial Interventions in Cancer.- Altruism in Relation to Live Donor Liver Transplants for Liver Cancer.- New and Emerging Challenges in Advanced Cancer Care: Opportunities for Enhancing Patient-Centered Communication.- Complementary Mind-Body Therapies in Cancer.- The Intersection between Cancer and Caregiver Survivorship.- Controversies in Psycho-Oncology.- Resources for Cancer Patients.- Adolescent and Young Adult Cancer Survivors.- Cancer Fatalism: Attitudes Toward Screening and Car.- The Intersection between Cancer and Caregiver Survivorship.- Cancer and the Aging Population.- Mindfulness Based Interventions for Patients with Cancer.- Social Genomics and Cancer: Neural Regulation of the Cancer Genome.- Psychological Aspects of Hereditary Cancer Risk Counseling and Genetic Testing: Toward an Expanded and More Equitable View.- Meaning-Centered Psychotherapy.- Quality of Life.- Bringing It All Together.

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Book SynopsisOver the last several decades breast cancer management has made great strides in the improvement of oncologic treatment outcomes, particularly so in patients with early stage disease. While wide-spread access to screening resulting in early detection is undoubtedly to be credited for this trend, at the same time, the management of breast cancer has evolved to be an intricate multidisciplinary collaboration between breast imagers, surgeons, medical oncologists and radiation oncologist. As a result, with better mutual understanding of multidisplinary goals and challenges, the treatment strategies have become more individualized, with a great emphasis being placed on the intrinsic disease biology. Furthermore, the indications for neoadjuvant systemic therapy have significantly broadened, with a substantial number of patients with early stage breast cancer being able to take advantage of this strategy to decrease the extent of breast surgery they would undergo at its completion. As such, the management of the axilla in these patients has presented with new challenges as well as with new opportunities to scale down on the extent of local therapy and, consequently, its toxicity.This text will provide a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians (surgeons, medical oncologists, radiation oncologists) and researchers with an interest in breast cancer. The book will review novel and evoling strategies in neoadjuvant systemic therapy forn early stage breast cancer, provide new perspectives about appropriate axillary imaging in anticipation of neoadjuvant systemic therapy, and describe new data on innovative surgical techniques and Radiation Oncology concepts designed to deescalate the extent and toxicity of local therapy while insuring oncologic safety. Several landmark clinical trials have been published in the last few years and will be placed in context with respect to current management. Integration of novel diagnostic and interventional breast imaging, local therapy (surgery and radiation) with contemporary systemic therapy will also be discussed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging field. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.Table of ContentsEvolution of the indications for neoadjuvant systemic therapy.- Defining response.- Imaging of the breast.- Imaging of the axilla and approach to node-negative vs. node-positive disease at presentation.- Guidelines for imaging during neoadjuvant systemic therapy.- Neoadjuvant systemic therapy based on the underlying tumor biology.- Adjuvant vs. neoadjuvant systemic therapy.- Molecular testing and personalized neoadjuvant treatment.- Pre-and post-neoadjuvant systemic therapy imaging assessment.- Surgical management of the axilla in node-negative and node-positive disease at diagnosis.- Surgical considerations and expectations in patients receiving neoadjuvant hormonal therapy and neoadjuvant chemotherapy.- Postmastectomy radiation considerations in patients receiving neoadjuvant chemotherapy.- Pathologic evaluation in neoadjuvant systemic therapy setting.- Guidelines for Neoadjuvant systemic therapy.- Ongoing Clinical studies and future direction.

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Book SynopsisThis textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. Table of Contents

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Book SynopsisThis book comprehensively covers the techniques available for robot- assisted prostatectomy. Chapters feature detailed descriptions of how to successfully perform a variety of relevant techniques including the reconstruction of continence mechanisms and the use of the transperitoneal RALP anterior approach. Potential complications, preoperative and postoperative management strategies are also discussed, enabling the reader to develop a thorough understanding of how to apply a range of relevant methodologies into their day-to-day clinical practice and avoid commonly encountered pitfalls.Robot-Assisted Radical Prostatectomy: Advanced Surgical Techniques provides a practically applicable resource for all practicing and trainee urologists seeking a detailed overview of the latest advances in robot-assisted surgical procedures and current management strategies applicable to prostatectomy. Table of ContentsAn historical perspective of RALP.- Overviewing Robotic Surgical Technique.- How to start a RALP program.- Surgical anatomy of the prostate.- Preoperative imaging.- MRI imaging.- PET/CT imaging.- Transperitoneal RALP anterior approach.- Posterior approach to seminal vesicles .- Anatomical bladder neck dissection.- Retrograde Release of NVB with preservation of DVC.- Introperative assessment of surgical margins.- NEUROsafe.- Ex vivo fluorescence confocal microscopy.- Extra-fascial (non-nerve sparing).- Apical dissection.- Reconstruction of continence mechanisms.- Urethro-vesical.- Urethral suspension.- Bladder neck intussusception.- Posterior reconstruction.- CORPUS .- ARVUS .- Chinese technique.- Total anatomical reconstruction.- Transperitoneal RALP Retzius-sparing approach.- Bocciardi Technique.- Yonsei Technique.- Vattikuti technique.- Extra-peritoneal RALP.- Rochester technique.- Chinese Technique.- CUF Technique.- Pelvic lymph node dissection.- Predictive models.- Extended lymphadenectomy technique.- Fluorescence guided node dissection.- PSMA MRI fusion guided dissection.- Radio guided Surgery in Recurrent Prostate Cancer.- Techniques to prevent lymphocele formation in RALP.- Four-point Peritoneal Flap Fixation.- PLEAT.- Hernia repair during RALP.- Perineal RALP.- Tugcu Bakirkoy Technique.- Changhai technique.- Single-site RALP.- Cleveland Clinic technique.- UIC technique.- Changhai technique.- RALP in difficult situations.- Large median lobe.- Large volume gland with small pelvis.- Patients with previous BPH surgery.- Salvage RALP.- RALP for oligo-metastatic disease.- Augmented reality RALP.- Robot assisted partial prostatectomy for anterior cancer.- Complications in RALP: prevention and management.- Functional recovery after RALP.- Erectile function.- Continence.- Robotic training for RALP.

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Book SynopsisThis practical guide to the use of radiotherapy for the treatment of sarcomas and skin cancers covers a wide range of disease scenarios, identifying which treatment techniques are applicable in particular clinical circumstances. Among the conditions considered are extremity soft tissue sarcomas, retroperitoneal soft tissue sarcomas, bone sarcomas, uterine sarcomas, chordomas, pediatric sarcomas, squamous cell carcinomas, basal cell carcinomas, melanomas, Merkel cell carcinomas, and cutaneous lymphomas. Detailed attention is devoted to the issues and considerations of relevance in everyday practice when treating these diseases. The use of multiple radiotherapy techniques and procedures, including IMRT, brachytherapy, radiosurgery, and particle therapy, is fully explained, and the role of radiotherapy in combination with chemotherapy and emerging therapeutics such as immunotherapy and biologic anticancer agents is also addressed. The book will be of high value for practicing radiation oncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, trainees, and other medical professionals.Table of ContentsPART I: Sarcomas1. Extremity soft tissue sarcoma 2. Retroperitoneal soft tissue sarcoma 3. Gynecologic sarcomas 4. Bone sarcomas 5. Chordomas 6. Oligometastatic sarcomas 7. Pediatric sarcomas 8. Particle therapy for sarcomas 9. Chemotherapy / radiosensitizers PART II: Other soft tissue tumors: 10. Desmoid fibromatosis 11. Hemangiopericytomas / solitary fibrous tumors 12. Angiosarcomas 13. Dermatofibrosarcoma protuberans PART III: Skin cancers: 14. Squamous cell carcinomas 15. Basal cell carcinomas 16. Melanomas 17. Merkel cell carcinomas 18. Cutaneous lymphomas

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Book SynopsisThis open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos. This conference comes at an especially important time when Latinos – the largest and youngest minority group in the U.S. – are expected to face a 142% rise in cancer cases in the coming years. Disparities continue to impact this population in critical areas: access to preventive and clinical care, changeable risk behaviors, quality of life, and mortality. Each chapter summarizes the presentation and includes current knowledge in the specific topic areas, identified gaps, and opportunities for future research. Topics explored include: Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Optimizing Engagement of the Latino Community in Cancer Research Latino Population Growth and the Changing Demography of Cancer Implementation Science to Enhance the Value of Cancer Research in Latinos A Strength-Based Approach to Cancer Prevention in Latinxs Overcoming Clinical Research Disparities by Advancing Inclusive Research Advancing the Science of Cancer in Latinos: Building Collaboration for Action will appeal to a wide readership due to its comprehensive coverage of topics ranging from basic science and community prevention research to clinical practice to policy. The book is an essential resource for physicians and other medical professionals, researchers, scientists, academicians, patient advocates, and students. It also will appeal to policy-makers, NCI-designated cancer centers, academic centers, state health departments, and community organizations.Table of ContentsPart I Introduction 1..... Advancing the Science of Cancer in Latinos Amelie G. Ramirez, Edward J. Trapido Part II Health Threats in the Latino Community 2..... Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Paul D. Juarez, Darryl Hood, Min-ae Song, Aramandla Ramesh 3..... Population Health Challenges for Latinos in the US Alexander N. Ortega Part III Vulnerable Populations and Cancer Health Disparities 4..... Acute and Long-Term Neurological Complications of Acute Lymphoblastic Leukemia (ALL) Therapy in Latino Children Austin L. Brown, Kimberly P. Raghubar, Michael E. Scheurer, Philip J. Lupo Part IV Cancer Outcomes and Survivorship in Latinos 5..... Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Dinorah Martinez-Tyson, Erik L. Ruiz 6..... Cancer Care Delivery Among Breast Cancer Patients: Is It the Same for All? Catalina Malinowski, Mariana Chavez-MacGregor Part V Cancer in the Era of Precision Medicine 7..... Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women Lizeth I. Tamayo, Elam Day-Friedland, Valentina A. Zavala, Katie M. Marker, Laura Fejerman 8..... Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy Kenneth S. Ramos, Stefano Guerra, Randa El-zein Part VI Engaging Latinos in Cancer Research 9..... Optimizing Engagement of the Latino Community in Cancer Research Lourdes Baezconde-Garbanati, Bibiana Martinez, Carol Ochoa, Sheila Murphy, Rosa Barahona, Carolina Aristizabal, Yaneth L. Rodriguez Part VII Emerging Policies Impacting Latino Care 10.... Latino Population Growth and the Changing Demography of Cancer Rogelio Sáenz 11.... Financial Hardship, Food Insecurity, and Forgone Medical Care Jean A. McDougall, Shoshana Adler Jaffe, Dolores D. Guest, V. Shane Pankratz, Charles L. Wiggins, Angela L. W. Meisner, Andrew L. Sussman Part VIII Implementation Science, Innovative Technologies and the Future of Cancer Care 12.... Implementation Science to Enhance the Value of Cancer Research in Latinos: A Perspective from the National Cancer Institute Gila Neta 13.... Advancing E-health Interventions in Cancer Control and Survivorship for Hispanic/Latina Breast Cancer Patients Sharon H. Baik, Joanna Buscemi, Laura B. Oswald, Diana Buitrago, Judith Guitelman, Francisco Iacobelli, Melissa A. Simon, Frank J. Penedo, Betina Yanez Part IX Latino Lifestyles: Acculturation, Nutrition, and Health 14.... Impact of Obesity and Related Factors in Breast Cancer Survivorship Among Hispanic Women Elisa V. Bandera, Chi-Chen Hong, Bo Qin 15.... A Strength-Based Approach to Cancer Prevention in Latinxs Marisa S. Torrez-Ruiz, Sandra Soto, Nanette V. Lopez, Elva M. Arredondo Part X Advances in Cancer Therapy and Clinical Trials 16.... Overcoming Clinical Research Disparities by Advancing Inclusive Research Melissa Gonzales Part XI HPV Vaccination for Cancer Prevention 17.... The Road to Cervical Cancer Elimination Anna R. Giuliano Part XII Latino Cancer Health Disparities: Moving Forward 18.... Looking Forward: Continuing the Collaboration for Action Amelie G. Ramirez, Edward J. Trapido Appendix A: Advances in Biology and Treatment of Cancer Appendix B: Cancer Epidemiology and Prevention Appendix C: Engaging Latinos in Research Across the Cancer Continuum Appendix D: Living with and Beyond Cancer: Taking Action to Improve Outcomes

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Book SynopsisThis open access book is a collection of articles based on presentations from the 2020 Advancing the Science of Cancer in Latinos conference that gives an overview of conference outcomes. The vision of the conference has been to unite researchers, scientists, physicians and other healthcare professionals, patient advocates, and students from across the world to discuss research advancements, identify gaps, and develop actionable goals to translate basic research findings into clinical best practices, effective community interventions, and professional training programs to decrease cancer risks and eliminate cancer disparities for Latinos. This conference comes at an especially important time when Latinos – the largest and youngest minority group in the U.S. – are expected to face a 142% rise in cancer cases in the coming years. Disparities continue to impact this population in critical areas: access to preventive and clinical care, changeable risk behaviors, quality of life, and mortality. Each chapter summarizes the presentation and includes current knowledge in the specific topic areas, identified gaps, and opportunities for future research. Topics explored include: Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Optimizing Engagement of the Latino Community in Cancer Research Latino Population Growth and the Changing Demography of Cancer Implementation Science to Enhance the Value of Cancer Research in Latinos A Strength-Based Approach to Cancer Prevention in Latinxs Overcoming Clinical Research Disparities by Advancing Inclusive Research Advancing the Science of Cancer in Latinos: Building Collaboration for Action will appeal to a wide readership due to its comprehensive coverage of topics ranging from basic science and community prevention research to clinical practice to policy. The book is an essential resource for physicians and other medical professionals, researchers, scientists, academicians, patient advocates, and students. It also will appeal to policy-makers, NCI-designated cancer centers, academic centers, state health departments, and community organizations.Table of ContentsPart I Introduction 1..... Advancing the Science of Cancer in Latinos Amelie G. Ramirez, Edward J. Trapido Part II Health Threats in the Latino Community 2..... Applying an Exposome-Wide (ExWAS) Approach to Latino Cancer Disparities Paul D. Juarez, Darryl Hood, Min-ae Song, Aramandla Ramesh 3..... Population Health Challenges for Latinos in the US Alexander N. Ortega Part III Vulnerable Populations and Cancer Health Disparities 4..... Acute and Long-Term Neurological Complications of Acute Lymphoblastic Leukemia (ALL) Therapy in Latino Children Austin L. Brown, Kimberly P. Raghubar, Michael E. Scheurer, Philip J. Lupo Part IV Cancer Outcomes and Survivorship in Latinos 5..... Supportive Care Needs and Coping Strategies Used by Latino Men Cancer Survivors Dinorah Martinez-Tyson, Erik L. Ruiz 6..... Cancer Care Delivery Among Breast Cancer Patients: Is It the Same for All? Catalina Malinowski, Mariana Chavez-MacGregor Part V Cancer in the Era of Precision Medicine 7..... Genetic Ancestry and Breast Cancer Subtypes in Hispanic/Latina Women Lizeth I. Tamayo, Elam Day-Friedland, Valentina A. Zavala, Katie M. Marker, Laura Fejerman 8..... Precision Medicine Approaches for Stratification and Development of Novel Therapies of Latin(x) Patients at Risk of Lung Malignancy Kenneth S. Ramos, Stefano Guerra, Randa El-zein Part VI Engaging Latinos in Cancer Research 9..... Optimizing Engagement of the Latino Community in Cancer Research Lourdes Baezconde-Garbanati, Bibiana Martinez, Carol Ochoa, Sheila Murphy, Rosa Barahona, Carolina Aristizabal, Yaneth L. Rodriguez Part VII Emerging Policies Impacting Latino Care 10.... Latino Population Growth and the Changing Demography of Cancer Rogelio Sáenz 11.... Financial Hardship, Food Insecurity, and Forgone Medical Care Jean A. McDougall, Shoshana Adler Jaffe, Dolores D. Guest, V. Shane Pankratz, Charles L. Wiggins, Angela L. W. Meisner, Andrew L. Sussman Part VIII Implementation Science, Innovative Technologies and the Future of Cancer Care 12.... Implementation Science to Enhance the Value of Cancer Research in Latinos: A Perspective from the National Cancer Institute Gila Neta 13.... Advancing E-health Interventions in Cancer Control and Survivorship for Hispanic/Latina Breast Cancer Patients Sharon H. Baik, Joanna Buscemi, Laura B. Oswald, Diana Buitrago, Judith Guitelman, Francisco Iacobelli, Melissa A. Simon, Frank J. Penedo, Betina Yanez Part IX Latino Lifestyles: Acculturation, Nutrition, and Health 14.... Impact of Obesity and Related Factors in Breast Cancer Survivorship Among Hispanic Women Elisa V. Bandera, Chi-Chen Hong, Bo Qin 15.... A Strength-Based Approach to Cancer Prevention in Latinxs Marisa S. Torrez-Ruiz, Sandra Soto, Nanette V. Lopez, Elva M. Arredondo Part X Advances in Cancer Therapy and Clinical Trials 16.... Overcoming Clinical Research Disparities by Advancing Inclusive Research Melissa Gonzales Part XI HPV Vaccination for Cancer Prevention 17.... The Road to Cervical Cancer Elimination Anna R. Giuliano Part XII Latino Cancer Health Disparities: Moving Forward 18.... Looking Forward: Continuing the Collaboration for Action Amelie G. Ramirez, Edward J. Trapido Appendix A: Advances in Biology and Treatment of Cancer Appendix B: Cancer Epidemiology and Prevention Appendix C: Engaging Latinos in Research Across the Cancer Continuum Appendix D: Living with and Beyond Cancer: Taking Action to Improve Outcomes

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Book SynopsisThis open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.Table of ContentsHistory of Radiation Biology.-Basic Concepts of Radiation Biology.-Molecular Radiation Biology.-Mechanistic, Modelling and Dosimetric Radiation Biology.-Clinical Radiobiology for Radiation Oncology.-Radiobiology of Combining Radiotherapy with other Cancer Treatment Modalities.-Individual Radiation Sensitivity and Biomarkers.-Radiobiology of Accidental, Public and Occupational Exposures.-Environmental Radiobiology.-Space Radiobiology.-Radioprotectors, Radiomitigators and Radiosensitizers.-Ethical, Legal, Social and Epistemological Considerations of Radiation Exposure.

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Book SynopsisThis book will offer a practical guide for the surgical management of oncologic emergencies, that pose great challenges to both surgeons and oncologists. Combining the knowledge of experienced surgeons and oncologists, it describes the experience gained from daily life into a tertiary hospital. Every chapter will be focused on radical treatment of primary tumors, metastatic disease and palliation, and will include an “Highlight” section with 4-5 key messages at the beginning of each chapter, whereas at the end a flow-diagram will be employed to summarize the subject discussed topic. Every chapter will be written by at least two authors, including a surgeon and an oncologist, to guarantee a 360 degrees analysis of each topic. This work will benefit both surgeons and oncologists: surgeons will found in it a step to step practical tool that helps the decision making process, while oncologists will find interesting indications about how and when to involve a general surgeon into the management of an oncologic emergent condition.Table of ContentsHead and neck.- Adrenal glands.- Lung.- Esophagus.- Stomach.- Duodenum.- Small Bowel.- Right colon.- Appendix.- Left colon.- Rectum.- Liver.- Pancreas.- Gallbladder and biliary tract.- Spleen.- Uterus and Ovaries.- Kidney.- Urinary Bladder.- Peritoneal carcinosis.- Miscellaneous rare malignancies - Intra-abdominal lymphomas.- Miscellaneous rare malignancies – GIST.- Miscellaneous rare malignancies – Desmoplastic.- Miscellaneous rare malignancies – Sarcomas.- Miscellaneous rare malignancies - Pseudomixoma peritoneum.- Ethical issues.

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Book SynopsisThis book provides a practical, evidence-based approach to controversies in the management of thyroid nodules and differentiated thyroid cancer (DTC). Thyroid nodules are a commonly encountered clinical entity, identified in 2-6% of the population by palpation, and 20-35% by ultrasound. DTC is the solid organ cancer with the most rapidly increasing incidence (>50,000 new cases in the U.S. annually). Despite extensive research and multiple published comprehensive practice guidelines, numerous controversies remain within this field covering a wide range of issues, including incidence and epidemiology, radiographic evaluation, criteria for needle biopsy, cytopathologic and molecular diagnostics, active surveillance vs. operation for low-risk tumors, extent of surgery, indications for radioactive iodine treatment and external beam radiation, and optimal protocols for follow-up. The book takes a case-based approach: each chapter will begin with a patient presentation highlighting a particular controversial subject in thyroid nodules and DTC. The remainder of the chapter discusses the controversy within the context of current scientific understanding and clinical practice, using the latest evidence-based practice guidelines. Chapters conclude with a final review and discussion of the opening case, with options and recommendations for next steps provided. The recommendations are evidence-based and practical, intended to help guide practitioners in their ongoing care of patients with thyroid nodules and DTC. Each chapter was written by a recognized expert in the area of controversy, including endocrine surgeons, endocrinologists, radiologists, medical oncologists, and nuclear medicine specialists. Controversies in Thyroid Nodules and Differentiated Thyroid Cancer: A Case-Based Approach is an excellent guide for oncologists, endocrinologists, otorhinolaryngologists, surgeons, and practitioners of all types that care for patients with thyroid nodules and DTC.Table of ContentsChapter 01: Incidence and Epidemiology of Differentiated Thyroid Cancer: Is thyroid cancer incidence truly increasing, or is it simply a finder effect?Chapter 02: Criteria for Fine-Needle Aspiration Biopsy in Thyroid NodulesChapter 03: Preoperative Molecular Testing for Indeterminate Thyroid NodulesChapter 04: Active Surveillance of Low-Risk Differentiated Thyroid CancerChapter 05: Preoperative Laryngoscopy in Thyroid Surgery PatientsChapter 06: Radiofrequency Ablation for Thyroid NodulesChapter 07: Management of low-risk papillary thyroid cancer in a patient with familial non-medullary thyroid cancer Chapter 08: Intraoperative Nerve Monitoring in Thyroid OperationsChapter 09: Extent of Surgery for Low-Risk Papillary Thyroid CancerChapter 10: Surgical Management of Locally Advanced Thyroid Cancer with Tracheal InvasionChapter 11: Management of Central Neck Nodes in Papillary Thyroid CancerChapter 12: Impact of Surgeon Volume in Thyroid OperationsChapter 13: Intraoperative/Postoperative Calcium Management in ThyroidectomyChapter 14: Indications for Radioactive Iodine Therapy in Thyroid Cancer PatientsChapter 15: Recurrent Nodal Metastases of Papillary Thyroid CancerChapter 16: Management of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Features (NIFT-P)Chapter 17: Timing of long-term post-operative surveillance for low-risk differentiated thyroid cancerChapter 18: External-Beam Radiation for Patients with Differentiated Thyroid Cancer – Is There a Role?

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Book Synopsis Pancreatic cancer is a challenging and complex disease characterized by a dense fibrotic stroma and an immunosuppressive tumor microenvironment. Until recently, there were no predictive biomarkers to personalize selection of targeted or biologic therapies as a part of standard of care treatment. Moreover, the regulatory immune population of cells creates a “cold”, non-immunogenic tumor that is resistant to immunotherapies including checkpoint inhibitors. However, in the last few years, there has been substantial progress in our understanding of the role mutations in the pathogenesis of disease leading to increased adoption of germline and next generation sequencing to identify mutations and fusions to optimize selection of therapies and select patients for clinical trials of targeted agents.This book provides a comprehensive, global overview on therapy for pancreatic cancer, exploring approved therapies and focusing on the “Next” in drug development including molecularly targeted therapy and efforts at “Drugging the Undruggable”: the KRAS mutation. It also addresses efforts at targeting the inhospitable stroma to improve drug delivery to the tumor cells, incorporating ct DNA (liquid biopsies) in the care of patients and recent advances in immunotherapy. Pancreatic Cancer: Current Therapeutics and Future Directions will illuminate these challenges, review existing therapeutics, and highlight current and future efforts to improve outcomes in this devastating disease. Useful to physicians, fellows, medical students, residents, physician assistants, nurse practitioners, pharmaceutical companies and researchers interested in pancreatic cancer, it will first explain management of localized disease including resectability and adjuvant and neoadjuvant therapies. Targeted therapies including molecular, immunotherapy, stroma and role of ctDNA or “liquid biopsies” will be addressed. Finally, the book will explore the important role of pain management, diet and exercise in improving outcomes in pancreatic cancer.Table of ContentsResectable Pancreatic Cancer: Neoadjuvant and Adjuvant Therapy.- Borderline Resectable and Locally Advanced Pancreatic Cancer.- Radiation Therapy for Pancreatic Cancer: Current and Evolving Paradigms.- Therapies for Metastatic Pancreatic Cancer.- Targeted Therapies for Pancreatic Cancer.- Immunotherapy for Pancreatic Cancer.- Liquid Biopsies for pancreatic cancer: Is it ready for prime time?.- Supportive Care challenges and management in Pancreatic Cancer.- Physical activity and nutrition optimization in pancreatic cancer.

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Book SynopsisMuch research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of Springer Nature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the 20th volume of a continuing series.Table of Contents1.- Krishna Kumar Haridhasapavalan , Atreyee Borthakur , Rajkumar P Thummer - Direct Cardiac Reprogramming: Current Status and Future Prospects2.- Ayça Aslan, Selcen Arı Yuka - Stem Cell-Based Therapeutic Approaches in Genetic Diseases3.- Akshaya Upadhyay , Uyen M N Cao , Arvind Hariharan , Akram Almansoori , Simon D Tran - Gene Therapeutic Delivery to the Salivary Glands4.- Meryem Osum , Rasime Kalkan -Cancer Stem Cells and Their Therapeutic Usage5.- Ozlem Aybuke Isik , Onur Cizmecioglu -Rafting on the Plasma Membrane: Lipid Rafts in Signaling and Disease6.- Giulia Silvani , Valentin Romanov, Boris Martinac -Sounding a New Era in Biomechanics with Acoustic Force Spectroscopy7.- Akram Abdo Almansoori , Arvind Hariharan , Uyen M N Cao , Akshaya Upadhyay , Simon D Tran - Drug Therapeutics Delivery to the Salivary Glands: Intraglandular and Intraductal Injections8.- Toshifumi Yamashiro , Toshihiro Kushibiki , Yoshine Mayumi , Masato Tsuchiya , Miya Ishihara , Ryuichi Azuma - Negative-Pressure Wound Therapy: What We Know and What We Need to Know9.- Aziz Rodan Sarohan , Sait Edipsoy , Zeynep Gürsel Özkurt, Can Özlü , Ayça Nur Demir , Osman Cen - Vitamin A Deficiency, COVID-19, and Rhino-Orbital Mycormycosis (Black Fungus): An Analytical Perspective10.- Thudzelani Takalani Austin Malise , Ekene Emmanuel Nweke , Mutsa M Takundwa , Pascaline Fonteh Fru , Deepak B Thimiri Govinda Raj - Treatment Strategies for Multiple Myeloma Treatment and the Role of High-Throughput Screening for Precision Cancer Therapy

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Book SynopsisOncology is a field characterized as “medicine of high complexity” and cancer is generally regarded as a complex system. Therefore, it cannot be classified and treated according only to its biology. Even though research on the biology of cancer has increased and more studies have been published, the related sociological, political and economic dimensions, as well as mathematical models that predict whether this condition will take one course or another, have often been neglected. The Invisible Hand of Cancer—The Complex Force of Socioeconomic Factors in Oncology Today unfolds the variables behind the biological disease, exploring the social aspects and presenting cancer as a model inside of the Complexity Theory. Cancer is a generic word for more than 200 diseases. In a wider view of cancer treatment, the various factors of cancer interact in multiple ways and it is a difficult task to identify and understand all the possible combinations in this system. All these variables and how they interact can be defined as the invisible hand of cancer. This book does not intend to be an exhaustive analysis of these aspects. It is a door being opened to the cancer research journey, along the years and beyond its biology. It will also discuss how social behavior can interfere in the evolution of cancer treatment, as a result of society’s way of thinking and choices, thus the importance of truly addressing cancer as an intricate system and a public health issue. After the success of my children’s books about cancer (Chubby’s Tale: The true story of a teddy bear who beat cancer, Bald is Beautiful: A letter for a fabulous girl, Cancer Daily Life, and What is Cancer?: A book for kids), I have developed a passion for writing about science in a simple way for non-scientist readers. I have also worked to build a career as a writer, communicating with patients, advocates, and oncology and pediatric oncology professionals, mostly on Twitter. Everyone knows someone who has or had cancer, so more and more popular science books on this topic are becoming bestsellers. This book is directed to a general audience and follows scientific standards, encompassing high-quality data, but in an easy-to-read format. Furthermore, it will raise awareness and show how simple actions such as not judging patients and not spreading false popular beliefs can contribute to achieve a new milestone in the cancer journey.Table of Contents1. The Blame Game This chapter will address how our society often blames cancer patients, associating habits and some types of cancer. It will measure the psychological impacts, question and show data (in a comprehensible way) to conclude what habits and how much they really can cause cell mutation and cancer. The blame game's sociological aspects are analyzed, which is a psychological and cultural behavior (proved by consistent data) of judging people by their type of cancer. Confronting popular habits and theories with science, the first chapter will address the question of how much habits can really interfere with the complex mechanisms of cancer development, and how fair is the way cancer is approached in the media and society. More than that, it opens the discussion about how it interferes in treating cancer as a public policy. 2. The Broken Machine This chapter is about the biology of cancer and how our repair mechanisms work to avoid cancer development. The various mechanisms of repair are listed and it is explained why they can sometimes not function properly. 3. Healthy and Fitness — to be, or not to be, that is the question This chapter confronts common knowledge about what is considered healthy. It includes data, as well as mechanisms of mutation of some substances (in a reader-friendly way), and shows how these substances can easily be avoided in daily life. It also discusses the safety of some preservatives in food and other substances that are approved in many countries. 4. Chaos and Complexity This chapter addresses physical chemistry in an easy-to-read format for non-scientists. It explains the complex organization of cancer, how it can adapt itself to the body, and if its biology tends to chaos. 5. Life and Death Are Made Of Five Letters: A, T, C, G, U This chapter is about genetics: DNA, RNA, and the code of life and death. 6. Panem et Circenses This chapter includes an analysis of news and popular information about cancer and their social effects, detailing how the popular excitement over false promises influences government decisions and other cause-effect analyses. 7. Metastasis — When biology favors that cancer follows its way This chapter highlights the biology of metastasis and the many characteristics that lead a patient to develop metastatic cancer. 8. Treating Cancer This chapter presents drugs, radiotherapy and surgery in cancer treatments. It discusses why each treatment works for some patients and not for others. Stem cell transplantation, CART-cells and other relatively new therapies are also featured, describing how individual biology interferes. Special attention is given to CART-cells and cellular therapies.9. Cancer and Incarceration Incarcerated patients are a specific population and often have their needs neglected, representing a major health issue. Therefore, this chapter will discuss health and cancer in the prison system of the United States. 10. Cancer in Germany, the US, and Brazil This chapter will compare cancer treatment, public policies, health systems, financial toxicity and other social factors related to cancer in Germany, the United States and Brazil. 11. When the Same Way is Longer: Cancer Social Determinants This chapter will analyze the social determinants of cancer and how healthcare is managed in different countries. In many developing countries cancer is not regarded as a national priority since the major health problems are related to malnutrition, deaths of neonates during delivery and neglected infectious diseases, such as malaria. Another issue linked to social conditions is the choice of health insurance, which will also be addressed in this chapter. 12. Financial Toxicity This chapter will address the high-cost of cancer treatments and how it affects patients and their caregivers. 13. When the Same Disease Can Have Different Psychological Impacts in Different Countries This chapter will compare the psychological impacts of cancer in different countries.

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Book SynopsisEpidemiology, Presentation, and Evaluation.- Pathology of Neuroblastoma.- Genetic Predisposition.- Part I: Evolving Concepts in Neuroblastoma Pathogenesis (Seed):Tumor Genomics: Copy Number Alterations.- Tumor Genomics: Epigenetics.- Tumor Genomics: Genomic Regulation .- Tumor Metabolism.- Part II: Evolving Concepts in Neuroblastoma Immunology and Tumor Microenvironment (Soil): Neuroblastoma Tumor Microenvironment - Adaptive and Innate Immunity.- Neuroblastoma Tumor Microenvironment Non-Immune Cells and Exosomes.- Part III: Evolving Concepts in Neuroblastoma Precision Medicine: Targeting the Seed and the Soil: Advances in evaluating tumor burden.- Therapeutically Actionable Genetic Aberrations.- Re-engaging the Immune System:  Future of Immunotherapy.- Future of Clinical Trials and Application of Precision Medicine.- Summary and the Next 10 Years.      <

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Book Synopsis

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Book SynopsisI. The history of IA drug delivery (Chapter 1).-II. The pharmacokinetics of intraarterial drugs.-The conventional approach to modeling IA drug delivery (Chapter 2).-Flow dynamics of regional drug delivery (Chapter 3).-Flow-controlled kinetics of intraarterial drugs (Chapter 4).-Optical methods to investigate ultrafast IA drug kinetics (Chapter 5).-III. Current applications of IA drugs.-Specific cancers.- Retinoblastomas (Chapter 6).-Metastatic liver cancer ((Chapter 7).-Glioblastomas (Chapter 8).-Locally invasive breast cancers (Chapter 9).-Pelvic malignancy (Chapter 10).-Head and neck tumors (Chapter 11).-Neurological diseases.-Treatment of cerebral vasospasm (Chapter 12).-Stroke and local brain cooling (Chapter 13).-Blood-brain barrier disruption (Chapter 14).-Intraarterial thrombolysis for peripheral vascular disease (Chapter 15).-IV. Experimental applications of IA drugs.-Nanoparticle delivery (Chapter 16).-Carrier-mediated delivery (Chapter 17).-Gene delivery (Chapter 18).-Stem cell delivery (Chapter 19).-V. Technologies to deliver IA drugs.-The development of future intraarterial drugs (Chapter 20).-Balloon occluding catheters for drug delivery (Chapter 21).-Infusion pumps design and challenges (Chapter 22).-Robotic endovascular surgery (Chapter 23).-Self-navigation and artificial intelligence (Chapter 24).-VI. Conclusion: The future of intraarterial Drug Delivery (Chapter 25).

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Book Synopsis1. Overview on Cancer Biology and cancer hallmarks.- 2. Introduction to Seven “R”s of Radiobiology.- 3. Radiosensitivity and its contributing biologic factors.- 4. Innovative Strategies to Enhance Radiosensitivity: Hyperthermia, Nanoparticles, and DNA Repair Inhibition.- 5. Role of Tumor-Initiating Stem Cells in Tumor Resistance and Relapse.-  6. Cancer Cell’s Fates upon Radiation.- 7. Overview of Radiotherapy Techniques and Modalities: Conventional and Modern Approaches.-  8. Recent Advances in Radiotherapy of Breast cancer.-  Chapter 9 Advances in Radiotherapy of Gastrointestinal Cancers.-  10. Recent Advances in Radiotherapy of Lung Cancer.-  11. Advances in Radiotherapy of Genitourinary Cancers.-  12. Advances in Radiotherapy of Brain Tumors.-  13.  Advances in Head and Neck Cancer.- 14. Application of radiotherapy in oligometastatic disease.-  15. Emerging Role of FLASH Radiotherapy.- 16. Novel Approaches to Counteract Radiotherapy Toxicities: Focusing on Radioprotectors and Radiation Mitigators.- 17. Advances in Radiotherapy using Artificial Intelligence.- 18. Radiogenomics: A Potential Approach for Personalized radiotherapy. 19. The Emerging role of Microbiome in Radiation Research.- 20. Future Directions in Radiobiology and Clinical Radiation Oncology.

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Book Synopsissee attachment.

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Book SynopsisThe subject matter of volume 1 of the 2-volumes-handbook focusses on leiomyosarcoma, low-grade and high-grade endometrial sarcoma and undifferentiated uterine sarcoma of the whole female genitalia. A separate extensive chapter is devoted to the variants of leiomyoma (angio-, lipo-, cotyledonoid, cellular, mitotically active, epithelioid and myxoid leiomyoma, leiomyoma with bizarre nuclei), atypical smooth muscle tumors (smooth muscle tumors with uncertain malignant potential), and disseminated peritoneal leiomyomatosis, benign metastasizing leiomyoma, and intravenous leiomyomatosis. Furthermore, endometrial stromal tumors – endometrial stromal nodules, endometrial stromal tumor with sex cord-like elements (ESTSCLE), uterine tumor resembling ovarian sex-cord tumor (UTROSCT) - and similar tumors are described in detail. The book provides a description at length of the epidemiology, etiology, pathological anatomy, prognosis, diagnosis, differential diagnosis, imaging and comprehensive therapy of each primary, relapsed, and metastasized tumor including surgery, chemo-, hormone- and radio- and targeted therapy. Another chapter is devoted to the prevention of subjecting sarcomas to inadequate surgical therapeutic measures under the assumed diagnosis of leiomyoma, and includes a diagnostic-therapeutic flowchart with a diagnostic score. The book aims to identify and provide diagnostic and therapeutic guidance. The listed tumor entities also constitute a particular diagnostic challenge for pathologists that contains numerous pitfalls and difficulties. This book, therefore, addresses gynecologists and pathologists in both clinical and private practice, but also surgeons and hemato-oncologists.

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Book Synopsis

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Book SynopsisAll the information needed for successful diagnosis and management of breast carcinoma Focused on a modern, interdisciplinary approach to diagnosing and managing diseases of the breast, this concise book builds on the high standard set in the previous edition. It provides a complete foundation in the basic principles, radiologic appearance and underlying pathology of breast disease, without overwhelming non-pathologist members of the team with excessive detail. For effective communication at every level, Practical Breast Pathology, Second Edition provides the clear information, case examples and superb illustrations that make it an ideal clinical problem solver. Special features of the second edition: High-quality examples of modern multimodality radiology (digital mammography, ultrasound and magnetic resonance imaging) correlated with large-format 2D and 3D histologic slides New findings on such clinically important topics as the lobar nature of breast carcinoma, multifocality, diffuse carcinomas and extent of disease, concept of the sick lobe and more Introduction of the molecular classification of invasive breast cancer Discussion of prognostic and predictive factors in breast carcinoma, such as hormone receptors and HER2 status Updates on preoperative diagnosis, including intact biopsy and radiologic assessment of the extent and distribution of lesions Enriched with new information and stunning illustrations in every chapter, Practical Breast Pathology, Second Edition is a key link in the exchange between pathologists, radiologists, oncologists and breast surgeons, as well as residents and trainees. It provides an essential framework for understanding the mammographic-pathologic correlation, leading to increased cooperation among clinical team members and significantly improved outcomes for patients.Table of Contents1. Normal Breast Tissue or Fibrocystic Change? 2. General Morphology of Breast Lesions 3. Hyperplastic Changes with and without Atypia 4. Ductal Carcinoma In Situ 5. The Most Common Types of Invasive Breast Carcinoma 6. The Most Common Benign Lesions and their Borderline and Malignant Counterparts 7. Fine-Needle Aspiration or Core Biopsy: A Preoperative Diagnostic Algorithm 8. The Postoperative Workup 9. Assessment of the Most Important Prognostic Parameters 10. Case Reports

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Book SynopsisDespite significant progress in the treatment of head and neck cancer using new techniques, including organ preservation strategies, recurrence still occurs in up to 50% of patients with locally advanced disease. Head and Neck Cancer Recurrence is the first comprehensive, evidence-based reference on this complex condition, providing state-of-the-art strategies for treating and managing recurrence at each site within the head and neck. With this book at hand, specialists will have guidelines for detecting the presence of a tumor, evaluating the extent and likelihood of successful salvage, determining the most effective treatment modalities, and assessing the potential impact on outcome and function. Special features: Brings together all the current evidence and expertise on the epidemiology, risk factors, clinical and imaging evaluation, and management of recurrent head and neck cancer tumors Includes both curative and palliative approaches, and discusses surgical, radiotherapeutic, and chemotherapeutic strategic options Contains substantial contributions by specialists in speech and language therapy, palliative care, psychology, epidemiology, and clinical cancer nursing to provide a holistic, multidisciplinary approach to the management of recurrence of head and neck cancers Brings the decision-making process to life with illustrative case studies that contain patient histories, clinical findings, treatment planning, and documented results The combination of the most recent clinical advances with the latest thinking in the field makes this book an essential resource for all head and neck surgeons, clinical oncologists, radiation oncologists, nurse practitioners, allied health professionals and senior trainees working to improve patient management and outcomes in this challenging arena.

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Book SynopsisThe first volume of this updated and revised edition deals with the surgical resection of intracranial tumors. Individual chapters focus on specific intracranial regions, and provide neuroanatomic descriptions of all the major neurosurgical approaches in detail.Table of Contents1 Supratentorial Tumors 2 Tumors of the Base of the Skull 3 Infratentorial Tumors

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Book SynopsisThis textbook is designed to help the busy radiation oncologist to accurately and confidently delineate tumor volumes for conformal radiation therapy (including IMRT). The book provides an atlas of clinical target volumes (CTVs) for commonly encountered cancers, with each chapter illustrating CTV delineation on a slice-by-slice basis, on planning CT images. Common anatomic variants for each tumor are represented in individual illustrations, with annotations highlighting differences in coverage. The anatomy of each site and patterns of lymphatic drainage are discussed, and their influence on the design of CTVs is explained in detail. Utilization of other imaging modalities, including MRI, to delineate volumes is highlighted. Key details of simulation and planning are briefly reviewed. Although the emphasis is on target volume delineation for conformal techniques, information is also provided on conventional radiation field setup and design when IMRT is not suitable.Table of ContentsHead and Neck Cancer: Nasopharynx.- Oropharynx Cancer.- Early Larynx.- Advanced larynx.- Hypopharyngeal Cancer.- Oral Cavity Cancer.- Paranasal Sinuses.- Major Salivary gland.- Thyroid Cancer.- Cranial Nerves.- Unknown Primary.- Head and Neck.- Neck.- Breast Cancer: Early Breast Cancer.- Locally Advanced Breast.- Thorax: Locally Advanced NSCLC &SCLD.- SBRT and post-OP NSCLC.- Gastrointestinal Cancer: Esophagus.- Gastric.- Pancreatic.- HCC/Cholangiocarcinoma.- Rectal Cancer.- Anal Cancer.- Gynecological Cancer: Cervical Cancer.- Endometrial Cancer.- Ovarian Cancer.- Vaginal Cancer.- Vulvar Cancer.- Genitourinary Cancer: Prostate Cancer.- Bladder Cancer.-Seminoma .- CNS: Brain Metastasis.- Benign.- Low and High Grade Glioma.- Lymphoma: Hodgkin's Disease.- Non-Hodgkin's Disease.- Musculoskeletal.- Pediatrics: Sarcoma.- Pediatric CNS.

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Book SynopsisThis book looks at specific vascular surgery questions that have arisen and where careful analysis is given according to the level of supporting evidence available. As new technology is introduced to treat the cardiovascular system, alternative therapies begin to challenge and also complement traditional vascular surgery. All chapters contain the PICO table to summarise specific characteristics relative to the questions posed in each chapter.Difficult Decisions in Vascular Surgery- An Evidence-Based Approach is a current and timely reference source for practicing surgeons, surgeons in training, and educators, that describes the recommended ideal approach, rather than customary care, in selected clinical situations.Trade Review“This is a useful resource for vascular trainees or vascular attendings throughout their careers as they face difficult situations that they do not encounter on a routine basis. … This is an accessible and well‐organized resource for dissecting the components of decision-making for clinical scenarios in vascular surgery. It provides a useful overview of the literature for each scenario and management recommendations graded by level of evidence. I found it to be a good resource.” (Katherine Hekman, Doody's Book Reviews, April, 2017)Table of ContentsSection 1: Aortic Disease Ch. 1: In patients with Acute Type B Aortic dissection, do current operative therapies reduce complications compared to medical management? Ch. 2: In patients with a Chronic Type B dissection, does Endovascular treatment reduce long term complications? Ch.3: In patients with a retrograde Type A Aortic dissection, does treatment like a type B Aortic dissection improve outcomes? Ch.4: In patients with small AAA, does medical therapy prevent growth? Ch.5: Challenging AAA Neck Anatomy: Does the Fenestrated or Snorkel/Chimney Technique Improve Mortality and Freedom from Reintervention Relative to Open Repair? Ch.6: In patients who require Hypogastric artery coverage to treat an AAA with EVAR, does preservation improve outcomes when compared to exclusion of the vessel? Ch.7: In patients with aortic graft infections, does EVAR improve long term survival compared to open graft resection? Ch.8: Does EVAR improve outcomes or quality of life in patients unfit for open surgery? Ch.9: In patients with type 2 endoleaks does intervention reduce aneurysm related morbidity and mortality compared to observation? Ch.10: Ruptured Abdominal Aortic Aneurysm Treated with Endovascular Repair; Does Decompressive Laparotomy Result in Improved Clinical Outcomes? Ch.11: In a Patient with Blunt Traumatic Aortic Injury, Does TEVAR Improve Survival Compared to Open Repair or Expectant Management? Section 2: Lower Extremity Arterial Disease Ch.12: In patients with Aortoiliac occlusive disease, does Endovascular repair improve outcomes when compared to open repair? Ch.13: In Patients with Aortoiliac Occlusive Disease, Does Extra-anatomic Bypass Improve Quality of Life and Limb Salvage? Ch.14: In Patients with Critical Limb Ischemia Does Bypass Improve Limb Salvage and Quality of Life When Compared to Endovascular Revascularization? Ch.16: In the patient with Profunda artery disease, is open revascularization superior to endovascular repair for improving rest pain? Ch.17: In patients with limb-threatening vascular injuries, is there a role of prophylactic fasciotomy to reduce ischemic injury? Ch.18: In patients with Popliteal Entrapment Syndrome, does surgery improve quality of life? Section 3: Mesenteric Disease Ch.19: In patients with Acute Mesenteric Ischemia does an endovascular or hybrid approach improve morbidity and mortality compared to open revascularization? Ch.20: Chronic Mesenteric Arterial Disease Does an endovascular/hybrid approach improve morbidity and mortality as compared to open revascularization? Ch.21: In patients with mesenteric ischemia is single vessel reconstruction equivalent to multiple vessel revascularization? Ch.22: In patients with celiac artery compression syndrome, does surgery improve quality of life? Ch.23: In patients with the Superior Mesenteric Artery syndrome is Enteric Bypass superior to Duodenal Mobilization Ch.24: In patients with Renovascular hypertension is there a role for open or endovascular revascularization compared to medical management? Ch.25: Does endovascular repair reduce the risk of rupture compared to open repair in splanchnic artery aneurysms? Section 4: Cerebrovascular Disease Ch.26: In patients with asymptomatic carotid artery stenosis does current best medical management reduce the risk of stroke compared to intervention (endarterectomy or stent)? Ch.27: In patients with symptomatic carotid artery stenosis is endarterectomy safer than carotid stenting? Ch.28: In Patients Undergoing Carotid Endarterectomy, is the Eversion Technique Superior to a Patch Technique to Reduce Restenosis? Ch.29: In patients with a stroke attributable to a carotid artery stenosis, does waiting to operate reduce the risk of complications? Ch.30: In patients with a peri-procedural cerebral thromboembolism, Does Neurovascular rescue improve Clinical Outcome? Ch.31: In patients with extra-cranial carotid artery aneurysms, does an endovascular approach improve clinical outcomes compared to open repair? Ch.32: In Patients with Carotid Artery Dissection, is Stenting Superior to Open Repair to Improve Clinical Outcomes? Ch.33: In patients with cervico-thoracic vascular injuries is endovascular repair superior in long-term durability when compared to open repair? Section 5: Venous and Arteriovenous Disease Ch.34: In Patients with Iliofemoral Deep Vein Thrombosis Does Clot Removal Improve Functional Outcome when Compared to Traditional Anticoagulation? Ch.35: In morbidly obese patients undergoing major abdominal operative procedures, does inferior vena cava filter placement prevent massive PE? Ch.36: In patients with chronic venous stenosis, does placement of a stent improve patency compared to recurrent angioplasty? Ch.37: In Patients with Chronic Venous Ulcer is the Unna Boot Still the Best Approach to Wound Care Ch.38: In Patients with Threatened or Occluded Access Grafts, Is it Better to Salvage the Graft, or Create a New Site? Ch.39: In patients with new arteriovenous fistulas, are there effective strategies to enhance AVF maturation and durability beyond waiting? Section 6: Perio-operative Management Ch.40: In patients with cardiovascular disease, do statins alone, or in combination with other medications improve mortality?Ch.41: In patients who have undergone a lower extremity bypass for PAD, does dual anti-platelet therapy improve outcomes?Ch.42: In patients undergoing vascular surgery, does preoperative coronary revascularization reduce the risk of myocardial infarction and death?

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Book SynopsisThis book presents up to date debates and issues in the world of breast MRI with a very practical focus on how to incorporate current understanding of breast MRI into clinical practice. The book is divided into three key sections, all of which have critical impact for the breast imager: Techniques introduces the reader to the parameters of breast MRI from standard sequences to up-to-date cutting edge techniques. Indications provides a careful review of the accepted indications for breast MRI from High Risk Screening to use of breast MRI, in the context of neoadjuvant chemotherapy with a detailed analysis of the evidence-based support for these indications and a careful look at controversies and debates within the field. MRI Findings, Interpretation, and Management takes on the topics of how to interpret and manage specific MRI findings from benign to malignant disease with a focus on radiologic-pathologic correlation. The section also incorporates a focus on key management dilemmas, including appropriate follow-up intervals for benign findings on MRI and management of probably benign lesions assessed as a Breast Imaging Reporting and Dictating System (BI-RADS)-3 category on MRI.Trade Review“This book is a comprehensive overview of the now well-established technique of breast MRI in the assessment of breast disease. … This book is most likely to be of interest to radiologists in sub-specialty training in breast imaging, but would also be of interest as a reference text to consultant radiologists established in reporting breast MRI with a moderate level of experience. … The book is compact and well laid out.” (Mamatha Reddy, RAD Magazine, June, 2018)Table of ContentsSection 1. Techniques.- 1. Breast MRI Technique.- 2. Breast MRI: Standing Terminologies and Reporting.- Section 2. Indications.- 3. MRI and Screening.- 4. MRI and Preoperative Staging in Women Newly Diagnosed with Breast Cancer.- 5. Magnetic Resonance Imaging and Noeadjuvent Chemotherapy.- 6. Breast MRI and Implants.- 7. Problem Solving Breast MRI for Mammographic, Sonographic, or Clinical Findings.- 8. Post-Operative findings/recurrent disease.- Section 3. MRI Findings, Interpretation and Management.- 9. In Situ Disease on Breast MRI.- 10. MRI appearance of Invasive Breast Cancer.- 11. Targeted Ultrasound after MRI.- 12. Breast Biopsy and Breast MRI Wire Localization.- 13. Breast MRI and the Benign Breast Biopsy.- 14. BI-RADS 3 Lesions on MRI.- 15. Multiparametric Imaging: Cutting-Edge Sequences and Techniques including Diffusion-Weighted Imaging, Magnetic Resonance Spectroscopy, and PET/CT or PET/MRI.- 16. Abbreviated Breast MRI.- 17. Personalized Medicine, Biomarkers of Risk and Breast MRI.

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Book SynopsisOf all the techniques used to treat non melanoma skin cancer, the highest cure rates belong to the Mohs surgical procedure. Critical to this technique is optimal preparation and interpretation of frozen sections. The second edition of this highly successful atlas details both common and uncommon cutaneous neoplasms that can serve as a source of reference for established practitioners and a review for those in training. It includes new frozen section specimens, the most current diagnostic guidelines, and discussion of the advancements in tissue staining. There is also an additional chapter with self-study tools, where readers can test their knowledge using various images with a multiple choice answer format, followed by a discussion of the correct answer. With high resolution figures, the Atlas of Mohs and Frozen Section Cutaneous Pathology, Second Edition is the premier text on the topic, serving as a highly practical guide to microscopic analysis, diagnosis, and discrimination of common and problematic cutaneous neoplasms. Highlights of the Atlas include diagnosis of basic and routine dermatologic entities, diagnosis and distinction of rare and/or deadly neoplasms such as dermatofibrosarcoma protuberans and merkel cell carcinoma, a troubleshooting guide dealing with quality control of the frozen section technique, and discussion of techniques including immunohistochemistry. Comprehensive and presented in full color, the Atlas of Mohs and Frozen Section Cutaneous Pathology, Second Edition is an indispensable reference for anyone involved with the Mohs procedure, including dermatologic surgeons, Mohs cutaneous surgeons, as well as pathologists and dermatopathologists who perform frozen section analysis of cutaneous specimens.Table of ContentsContentsSection I: Introduction1 Mohs and Frozen Section OverviewMichael B. Morgan, Terri Bowland2 Quality Assurance Dennis H. Nguyen, Daniel M. Siegel, Deborah Zell, Richard Spallone, Michael B. MorganSection II: Tumors of the Epidermis/Adnexae3 Histology with Regional and Ethnic Variation Michael B. Morgan, John R. Hamill, Jr.4 Benign Epidermal Tumors Michael B. Morgan5 Pseudotumors Martin Dunn, Michael B. Morgan6 Squamous Cell Carcinoma: Variants and Challenges Michael B. Morgan7 Basal Cell Carcinoma: Variants and Challenges Michael B. Morgan8 Adnexal Neoplasms Michael B. Morgan9 Malignant Adnexal Neoplasms Ryan S. Jawitz, Jack C. Jawitz, Michael B. Morgan10 Merkel Cell Carcinoma Michael B. Morgan11 Sebaceous Tumors Michael B. Morgan12 Paget’s Disease Michael B. Morgan13 Melanocyte Pathology Michael B. MorganSection III: Tumors of the Dermis14 Benign Mesenchymal Tumors Michael B. Morgan15 The Sarcomas Aaron M. Bruce, James M. Spencer16 Lymphoid Pathology John R. Hamill Jr., Michael B. MorganSection IV: Special Topics17 Perineural Pathology Martin Dunn, Michael B. Morgan18 Cytopathology of Cutaneous Tumors Kenneth B. Calder, Rahel Mathew, Michael B. Morgan19 Immunohistochemistry Applications Basil S. Cherpelis, L. Frank Glass, John R. Hamill Jr., Neil Alan Fenske20 Histotechnique and Staining Troubleshooting John R. Hamill Jr., Stephen SpencerSection V: Mohs Clinicopathologic Self-Test Series 21 A Painful Perineural Infiltrate Rebecca S. Thornhill, Tyler Scott22 A Painful Subcutaneous Nodule Rebecca S. Thornhill, Nicole Asher23 Basaloid LesionTyler Scott, Nicole Asher 24 Rapidly Growing Hemorrhagic PapuleRebecca S. Thornhill, Nicole Asher 25 Aggressive Spindle Cell NeoplasmRebecca S. Thornhill, Tyler Scott 26 Eyelid Tumor Nicole Asher, Tyler Scott27 Non-melanoma Skin Cancer with Anemia Rebecca S. Thornhill, Tyler Scott28 Follicular Neoplasm Tyler Scott, Nicole Asher29 Hemorrhagic Papule in a Patient with Lip Carcinoma Rebecca S. Thornhill, Tyler Scott30 Blue Ball in the DermisRebecca S. Thornhill, Nicole Asher

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Book SynopsisFollowing on the favorable reception of the first edition, the authors have thoroughly revised and updated the second edition of this resourceful clinical handbook. The book has been well received internationally by a wide audience of clinicians, including general dentists, oral surgeons, otolaryngologists, primary care physicians, nurse practitioners, dental hygienists, physician assistants, and dermatologists, and sales have been strong among students and post-graduate residents training in medical, dental, and allied health fields, supporting the versatility of this work and serving as testimony to its value in both the academic and private practice arenas. Several key updates and improvements have been made to the second edition. All informational content has been updated to ensure accuracy and relevance, particularly in the rapidly evolving fields of oncology and pharmacology. A new chapter has been added entitled “Oral Sequelae of Cancer and Cancer Therapy” which better organizes and consolidates previous content while expanding on topics such as targeted therapies and hematopoietic stem cell transplantation. Additional clinical images have been included throughout the book so that the full clinical spectrum of any given condition is well-represented. Furthermore, the print quality, as well as the positioning and layout of the clinical images has been improved for optimal utility. Lastly, the summary boxes that follow each condition have been reconfigured with color-coded icons for improved definition, ease of use and cross-referencing. Clinical Oral Medicine and Pathology, Second Edition will continue to serve as an authoritative contemporary resource for clinicians seeking guidance in the diagnosis and management of oral diseases.Trade Review“­The book is well structured with good flow from one chapter to the next. Each chapter is well laid-out with clear headings and illustrated text to help with diagnosis and management of oral medicine-related conditions. Concise descriptions of each condition provide background information and treatment recommendations with useful summary tables for quick reference. … this would be a useful resource for any healthcare professional seeing patients with oral disease.” (Anne M. Hegarty, British Journal of Hospital Medicine, Vol. 78 (1), January, 2017)Table of ContentsTable of Contents Chapter 1 Normal Anatomy Chapter 2 Variants of Normal and Common Benign Conditions Chapter 3 Diagnostic Tests and Studies Chapter 4 White Lesions Chapter 5 Immune-Mediated and Allergic Conditions Chapter 6 Pigmented Lesions Chapter 7 Oral Infections Chapter 8 Salivary Gland Disease Chapter 9 Oral Cancer Chapter 10 Orofacial Pain Conditions Chapter 11 Oral Manifestations of Systemic Disease Chapter 12 Oral Sequelae of Cancer Therapy Chapter 13 Prescribing Guidelines for Commonly Used Medicationsp>

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Book SynopsisThe lifestyles and socio-economic status that are prevalent in regions of the world with limited resources form the background for the unique features of neoplastic diseases in these areas, where the majority of the world population lives. The predominance of the world’s retroviral burden of in these areas further compounds the nature and challenges of the cancer there. Much of the international cancer literature covers the nature and challenges of the disease as seen in high-income regions of the world, thereby giving a skewed view of the global cancer challenges. As the low- and middle-income regions of the world transition from communicable to non communicable disease patterns, there is a need for a corresponding paradigm shift, with increased emphasis on what the world needs to know about non communicable diseases, including cancer, where the disease is hitherto poorly documented. The main goal of the proposed book is to contribute to this outcomes.Table of ContentsPart IV: Future Perspectives Chapter 10 – Strategies for progress Abstract Section 10.1.0: The role of international partnership in the development of global health systems Section 10.1.1: Models of humanitarian global outreach in health care Section 10.1.2: The concept of “convergence” and the future of health care research Section 10.1.3.0: The concept of global health Section 10.1.3.1: Models of global health partnership in cancer control Section 10.1.3.2: The tiered resource stratification framework of the Breast Health Global Initiative (BHGI) Network Section 10.1.3.3: ASCO’s resource-stratified guidelines for the management of invasive cervical cancer Section 10.1.3.4: NCCN framework for resource stratification for invasive cervical cancer Section 10.1.3.5: Resource-stratified approaches in the primary prevention of cervical cancer Section 10.1.3.5.1 ASCO resource-stratified guideline for the primary prevention of cervical cancer Section 10.1.3.6: Resource-stratified approaches in the secondary prevention of cervical cancer Section 10.1.3.4.1: Selected Global Health Activities for promoting cancer control/Health Volunteers Overseas (HVO) Section 10.1.3.4.2 Global Curriculum and Mentoring Program Section 10.1.3.4.3: Global Curriculum and Mentoring Program/International Development and Education Award Section 10.1.3.4.4: Proposal for recognizing global oncology as an academic field Section 10.2: Overcoming barriers to progress in the control of cancer and retroviral diseases, including HIV/AIDS Section 10.2.1: Prioritizing strategies for universal health coverage Section 10.2.1.1: mHealth Strategies for Universal Health Coverage Section 10.2.1.2: Community Health Insurance Coverage as a strategy for Universal Health Care Section 10.2.1.3: Innovation in provider training as a strategy in UHC Section 10.2.2: The role of politics in attainment of Universal Health Coverage Section 10.2.3: The role of science and engineering in human welfare Section 10.2.3.1: The role of science Section 10.2.3.1.1: Science advocacy Section 10.2.3.1.2: Science education in low- and middle-income countries Section 10.2.3.1.3 Examples of the transforming effect of science in LMICs Section 10.2.3.1.3.1 Impact of science on the emergence of South Korea Section 10.2.3.1.3.2: Impact of science on Middle-Eastern cooperation Section 10.2.3.1.3.3: Impact of the US-Cuba scientific diplomacy Section 10.2.3.1.3.4: Boosting science in Singapore Section 10.2.3.1.3.5: India boosts its ambitious space program Section 10.2.3.2: Transforming the practice of engineering to meet global health needs Section 10.2.3.3 Models in innovation with potentials for cancer and HIV/AIDS control in LMICs Section 10.2.3.3.1: Affordable, weather durable x-ray machine Section 10.2.3.3.2: Affordable cancer immunotherapy in Cuba Section 10.2.3.3.3: The smart village for rural electrification Section 10.2.3.3.4: HIV/AIDS control in China Section 10.3: The future of control of cancer and retroviral diseases Page 1055: Section 10.3.1: From the National Cancer Act to the 21st Century Cures Act Page 1059: Section 10.3.2: Advances in lung cancer prevention Page 1062: Section 10.3.3: Ending the HIV/AIDS pandemic Page 1063: Section 10.3.4: Finding a cure for AIDS – a possible convergence of cancer and HIV/AIDS researchIndex

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Book SynopsisThis text provides a comprehensive review and expertise on various interventional cancer pain procedures. The first part of the text addresses the lack of consistency seen in the literature regarding interventional treatment options for specific cancer pain syndromes. Initially, it discusses primary cancer and treatment-related cancer pain syndromes that physicians may encounter when managing cancer patients. The implementation of paradigms that can be used in treating specific groups of cancer such as breast cancer, follows. The remainder of the text delves into a more common approach to addressing interventional cancer pain medicine. After discussing interventional options that are commonly employed by physicians, the text investigates how surgeons may address some of the more severe pain syndromes, and covers the most important interventional available for our patients, intrathecal drug delivery. Chapters also cover radiologic options in targeted neurolysis and ablative techniques, specifically for bone metastasis, rehabilitation to address patients’ quality of life and function, and integrative and psychological therapies. Essentials of Interventional Cancer Pain Management globally assesses and addresses patients’ needs throughout the cancer journey. Written by experts in the field, and packed with copious tables, figures, and flow charts, this book is a must-have for pain physicians, residents, and fellows.Table of ContentsPart I: Perspectives on Cancer Pain Medicine.- Perspectives on Interventional Cancer Pain Management.- The Practice of Cancer Pain: A Case Series.- Part II: Cancer Pain Syndromes.- Pathophysiology of Cancer Cancer Pain.- Chemotherapy.- Post-Surgical Pain Syndromes.- Radiation-Induced Pain Syndromes.- Part III: Paradigms in Cancer Pain Syndromes.- General Pain Management Concepts.- Head and Neck.- Breast Cancer Pain: A Review of Pathology and Interventional Techniques.- Thoracic Cancer Pain.- Gastrointestinal Cancer Pain.- Genitourinary Cancer Pain Syndromes.- Pediatrics.- Pain in Hematologic Malignancies.- Dermatologic Cancer Pain Syndromes.- Part IV: Percutaneous Pain Techniques and Anatomy.- Ablative Techniques.- Sympathetic Nervous System Blocks for the Treatment of Cancer Pain.- Peripheral Nerve Blocks. Cranial Nerve Targets.- Vertebroplasty, Kyphoplastly, and Sacroplasty.- Treatment Considerations for Cancer Pain Syndromes.- Part V: Surgical Techniques Electrical Modulation.- Intracranial Neuroablation.- Spinal Neuroablation for Cancer Pain.- Radiosurgery.- Deep Brain Stimulation and Motor Cortical Stimulation for Malignant Pain.- Spinal Cord Stimulation and Oncologic Pain Management.- Peripheral Nerve Stimulation for the Treatment of Cancer Pain.- Transcutaneous Electrical Nerve Stimulation for Cancer Pain.- Part VI: Intrathecal Drug Delivery.- Indications for Intrathecal Pump Therapy.- Intrathecal Drug Delivery System Trialing for Cancer Pain Management.- Pump Implantation Technique.- Medications in Intrathecal Pumps.- Compounding Drugs for Intrathecal Use.-Part VII: Interventional Oncology.- Image Guidance and Planning.- Ablative Techniques for Painful Metastasis (PFA, Cryo, Chemical, HIFU).- Introduction to Radiation Therapy.- Palliative Radiation Therapy.- External Beam Radiotherapy in the Treatment of Painful Bone Mestastases.- Non-Opioid Intravenous Infusions for Management of Cancer Associated Pain.- Part VIII: Interventional Physiatry.- Cancer Rehabilitation.- Neuromuscular Medicine-Cancer Pain.- Cancer-Related Pelvic Pain.- Exercise Therapy and Fatigue Management.- Physical Therapy.- Occupational Therapy.- Cancer Pain and Physical Modalities.- Osteopathic Treatment for Cancer-Related Pain.- Rehabilitation Bracing as a Conservative Treatment Option.- Part IX: Complementary and Psycho-Behavioral Therapies.- Psycho-social Assessment and Treatment for Patients with Cancer Pain.- Relaxation Techniques and Biofeedback for Cancer Pain Management.- Mood and Anxiety in Cancer Pain.- Acupuncture and Cancer Pain.- Creative Therapies and Mind-Body Health Systems.- Botanical Treatments in Cancer Pain Management.- Integrative Therapies for Pain Modulation.

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Book SynopsisDie Herausgeber, anerkannte Spezialisten und aktiv in der Interdisziplinären Arbeitsgruppe Weichteilsarkome (IAWS) der Deutschen Krebsgesellschaft, stehen für fundiertes Fachwissen. Das Werk zeichnet sich durch eine praxisorientierte und übersichtliche Darstellung aller bei Weichteilsarkomen klinisch relevanten Themen aus. Ausführlich wird auf Diagnostik, Klassifikation, Stadieneinteilung wie auch molekulare und genetische Aspekte als Grundlage therapeutischer Entscheidungen eingegangen. Ein weiteres zentrales Thema ist die interdisziplinäre Behandlung (Chirurgie, Strahlentherapie, medikamentöse Therapie) und deren Sequenz für die zahlreichen, unterschiedlichen Entitäten von Weichteilsarkomen. Auch spezielle Therapieverfahren, wie Extremitätenperfusion und Hyperthermie werden besprochen. Ärzte in Klinik und Praxis erhalten mit diesem Buch kompetente Unterstützung für die optimale Betreuung von Patienten mit Weichteilsarkomen.Table of ContentsI. Epidemiologie II. Diagnostik III. Chirurgische Therapie IV. Strahlentherapie V. Medikamentöse Therapie VI. Spezifische Therapieverfahren VII. Nachsorge, Rehabilitation und PsychoonkologieAnhang

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Book SynopsisThis book is an ideal manual on the use of modern ultrasound in the diagnosis of breast pathology. It provides a comprehensive overview of current ultrasound techniques and explains the advantages and pitfalls of various ultrasound imaging modalities. Detailed attention is devoted to breast carcinoma, with guidance on differential diagnosis and presentation of pre- and postoperative ultrasound appearances. The most important benign breast diseases are also described and illustrated. Age-related features, including those seen in children and adolescents, are carefully analyzed, and an individual chapter is devoted to breast abnormalities in men. All aspects of lymph node appearances are reviewed in detail, with a special focus on the role of ultrasound in the evaluation of lymph node status. Ultrasound-guided breast interventions and imaging of breast implants are discussed in depth. This up-to-date and richly illustrated book will interest and assist specialists in ultrasound diagnostics, radiologists, oncologists, and surgeons.​Table of ContentsDiagnosis of Breast Cancer.- Technique of Breast Ultrasound.- Ultrasound of the Normal Breast .- Ultrasound Diagnosis of Breast Cancer.- Differential Diagnosis of Breast Diseases.- Breast Ultrasound in Children and Adolescents.- Breast Pathology in Men.- Ultrasound Examination of Regional Lymph Nodes.- Ultrasound Examination after Breast Surgery.- Recurrent Breast Cancer.- Ultrasound Imaging in Patients with Breast Implants.- Ultrasound-Guided Breast Intervention.- Conclusion.

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Book SynopsisUse of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors’ experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea and esophagus and miscellaneous items including the role of robotic surgery.Trade ReviewFrom the book reviews:“This book offers expert instruction on thoracic surgery through a cervical approach, covering current applications thoroughly and discussing future uses. … The book is written for practitioners and trainees in thoracic surgery. … This is a very useful book for practitioners of thoracic surgery interested in performing procedures through a cervical incision. It offers a detailed discussion of a topic often only covered in a textbook chapter. It will be a good addition to any reading on thoracic surgery.” (Michael Bates, Doody's Book Reviews, December, 2014)Table of ContentsDIAGNOSTIC AND STAGING SURGICAL ENDOSCOPIES.- Mediastinoscopy.- Extended Cervical Mediastinoscopy.- Remediastinoscopy.- Mediastino-Thoracoscopy.- Cervical Incision Thoracic Endoscopic Surgery (CITES).- Mediastinal Ultrasonography (MUS) as a Surgical Adjuvant In Lung Cancer Staging.- Video-Assisted Mediastinoscopic Lymphadenectomy (VAMLA).- Transcervical Extended Mediastinal Lymphadenectomy (TEMLA): The Standard Procedure And Its Variations.- THYMUS AND MEDIASTINUM.- Thymectomy Through Cervicotomy.- Transcervical Extended Thymectomy With Bilateral Opening Of The Mediastinal Pleura.- Transcervical Thymectomy With Bilateral Video-Assisted Thoracoscopic Surgery (VATS).- Rethymectomy.- Transcervical Resection Of Mediastinal Metastatic Nodes And Mediastinal Tumors.- Miscellaneous Indications: Mediastinitis, Cysts, Etc.- LUNGS AND BRONCHI.- Lobectomy.- Closure Of Postpneumonectomy Bronchopleural Fistula.- Closure Of The Main Bronchus Prior To The Definitive Pneumonectomy.- TRACHEA AND OESOPHAGUS.- Tracheal Resection.- Oesophageal Procedures.- MISCELLANY.- Thoracic Outlet Syndrome –Supraclavicular Approach.- Robotics. ​

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Book SynopsisManfred Georg Krukemeyer beschreibt zunächst das Magnetic Drug Targeting, unter dem man die zielgerichtete Arzneimittelapplikation – z. B. das Schleusen eines Zytostatikums – versteht und das eine Optimierung des lokaltherapeutischen Effekts erreichen soll. So erreicht der Autor am Ort des Tumors eine hohe Konzentration des Zytostatikums. Die Partikeln müssen groß genug sein, um von einem Magnetfeld angezogen zu werden, und wandern so in den Tumor, um dort ihren Wirkstoff freizusetzen. Ziel der Hypothese einer Studiengruppe des Autors war es, in einem wissenschaftlichen Experiment darzulegen, dass in diesem Fall Zytostatika an Eisenpartikeln gekoppelt [Fe3O4], in einen Tumor geschleust werden können. Das zielgerichtete Schleusen von Medikamenten – Magnetic Drug Targeting – führt zu einem schnelleren Erreichen des Wirkstoffs am Zielort bei einer verminderten Menge an Wirksubstanzen. Von daher ist das Magnetic Drug Targeting auch unter ökonomischen Aspekten interessant.Table of ContentsSarkome und deren Pathologie.- Magnetic Drug Targeting.- Tierversuche und Patientenuntersuchung, Tumortherapie beim Menschen.

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Book SynopsisEine Krebsdiagnose wirft die meisten Menschen aus der Bahn und bedeutet einen tiefen und bedrohlichen Einschnitt in ihr eigenes Leben, aber auch dasjenige ihrer Angehörigen. Die Erkenntnis, dass das Leben endlich und prekär ist, kann existenzielle Ängste, tiefe Trauer und Fragen nach dem Sinn auslösen, geht es ja letztlich um die Fragen nach Sterben und Tod. Wie können involvierte Fachpersonen mit diesen letzten Fragen der „conditio humana“ umgehen, wie können sie, trotz eigener Betroffenheit, angesichts dieser existenziellen Herausforderungen tragend und hilfreich sein? Diesen Fragen geht die vorliegende Publikation mit theoretischen Inputs sowie praktischen Vorschlägen für den Aufbau einer existenziellen Grundhaltung erfolgreich nach.Die Autorin Barbara Leu ist Psychotherapeutin (systemisch und existenzielle Ausrichtung) und Psychoonkologin am Kantonsspital Aarau, Schweiz. Daneben arbeitet sie als Psychotherapeutin in einer psychiatrisch/psychologischen Gemeinschaftspraxis in Zürich, Schweiz. Table of ContentsArten von Angst und Verlust.- Sinn im logotherapeutischen Verständnis und in der personalen Existenzanalyse.- Handhabung für die Praxis im Umgang mit Angst, Trauer und Sinn bei einer schweren Erkrankung.

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