Oncology Books

Book SynopsisAn estimated 166,400 new cases of cancer will occur in Canada in 2008. Bone metastases unfortunately remain a common site of recurrence, with breast and prostate cancer patients representing a substantial proportion of this population. Metastatic bone disease is associated with significant morbidity and mortality. Pain is experienced by up to two thirds of patients. The prognosis for patients with bone metastases is highly influenced by tumour type, performance status, and the presence of extraosseous disease. The median survival has been significantly longer in breast cancer patients with a first relapse in the axial skeleton (24 months) versus patients with initial relapse in the liver (3 months) (2). Survival after diagnosis of bone metastases is influenced by the subsequent development of extraosseous metastatic sites: 1.6 years versus 2.1 years in patients with bone-only disease.

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Book SynopsisThis book focuses on early diagnosis of the morphological changes in gastric mucosa, which are believed to be precursors for gastric cancer development. The use of modern imaging techniques in order to reveal and treat early cases of gastric cancer is also discussed. In addition, this book reviews modern data on gastric cancer prevention by means of screening gastric precancerous conditions and changes, as well as estimating the risk of gastric cancer development in individual patients with subsequent proper management for reducing the possibility of neoplastic progression.

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Book SynopsisMicroRNAs, or miRNAs, are a recently discovered class of small regulatory RNAs that influence the stability and translational efficiency of target messenger RNAs (mRNAs). Alterations in miRNA expression are associated with an increasing number of biological processes, including breast cancer. The study of miRNAs is a rapidly developing field that could considerably change our vision of breast cancer biology. This book offers an insight into our current knowledge of human miRNAs, with a specific interest for breast cancer.

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Book SynopsisBladder cancer refers to any of several types of malignant growths of the urinary bladder. It is a disease in which abnormal cells multiply without control in the bladder. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma. This book reviews research in the study of bladder cancer including recent advances in intravesical therapy for non-muscle invasive bladder cancer; molecular and genetic mechanisms in defining distinct genetic pathways of bladder cancer, and molecular proteins in urothelial carcinoma.

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Book SynopsisIn the past, cancer was considered a fatal disease due to the poor outcome of the patients and scarce possibilities of treatment. Decades later, a multimodal approach of therapy including surgery, conventional chemotherapy and radiotherapy has been applied with irregular success, making it the best known combination for survival at the early diagnostic stage, as well as having created a revolution in the field of oncology. This book describes approaches to be applied for the therapeutic management of patients with cancer.

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Book SynopsisFemale sex hormones are produced in both females and males. They influence almost every aspect of human physiological functions, activities and behaviours. Disturbance in female sex hormones may result in variety of disorders including cancer. Attention is usually focused on female sex hormone-related cancers in reproductive organs in females such as breast, cervix and ovary. However, advances in science have discovered that female sex hormones also have a great impact on cancers in non-reproductive organs and tissues such as colon, oesophagus and thyroid in both men and women. This book describes and summarises the up-to-date information on an emerging topic of female sex hormones and cancer.

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Book SynopsisOne of the major problems in clinical practice is the diagnosis of cancer and determining how to manage cancer patients. More than any other disease, cancer diagnosis and management at this time depends on a broad range of molecular and immunological tests. Diagnosis, determining therapeutic approach, monitoring effects of therapy, and detecting minimal residual disease all depend on both molecular and immunological methods. However, the two classes of methods are rarely discussed and presented in one book. This book is written specifically to show how both immunological and molecular techniques can be used in cancer diagnosis and management in order to bridge the gap between the two technologies.

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Book Synopsis"Horizons in Cancer Research" presents original research results on the leading edge of cancer. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.

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Book SynopsisEndocrine malignancies are rare tumours that are derived from endocrine cells located throughout the body. They encompass a heterogeneous group of malignancies, derived from different endocrine and neuroendocrine cells and have different clinically. The majority of endocrine neoplasms are benign, where the potential for invasion or metastasis is very low. Nevertheless, there is a group of endocrine neoplasms with malignant potential, and thus come under the management of medical oncology, often requiring systemic therapy. These include neuroendocrine tumours, anaplastic and medullary thyroid carcinomas, pheochromocytomas or paragangliomas, and adrenocortical carcinomas. While surgery continues to play a seminal role, the management of advanced endocrine neoplasia is more complex due to their rarity and heterogeneity. This book discusses the use of targeted therapy in the treatment of solid tumours and hematologic malignancies.

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Book SynopsisA tumour suppresser gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. This book presents topical research data in the study of tumour suppressers, including Rab GTPases as potential tumour suppressers; the regulation of neutrophil function by tumour suppresser PTEN; the role of BRIT1/MCPH1 in genome maintenance and tumour suppression; epigenetic silencing of tumour suppressers; and the relationship between MicroRNA and tumour suppressers.

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Book SynopsisThis book compiles biographical sketches of top professionals in the field of cancer research, as well as research summaries from a number of different focuses in this important field.

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Book SynopsisAlthough there have been tremendous progress in cancer research and treatment, the mortality caused by this disease is still very high. Cancer is the leading cause of death worldwide and second leading cause of death in the United States of America. The book covers topics including the role of various signalling pathway in development, regulation of cell fate, tumour angiogenesis, duodenal neoplasias, breast, colorectal and prostate cancer, cancer development and progression, microRNA in cancer and epigenetic regulation of cancer. This book will provide valuable information for cell biologists, geneticists, cancer biologists, clinicians, and students involved in various aspects of cell signalling, regulation of genes and cancer.

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Book SynopsisElectron microscopy made possible the observation of the cellular/subcellular behaviour of tumour cells in metastasis. The marked progress in molecular biology has enabled the identification of the molecules involved in metastasis. Cellular diversity of metastatic tumour cells and host cells is extremely important not only in understanding the irregular metastatic behaviour of malignant tumour cells but also in elucidating why such populations may display different responses to therapy. There have been advances in research showing that clinical cancer metastasis will eventually be conquered, at least in part. This is evident from the fact that pathologists are now able to report the primary site of a metastatic tumour to clinicians. Hopefully, this book will enlighten people in the medical and research field regarding new research in cancer and the interested reader as well.

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Book SynopsisThis book represents original findings and observations that were made recently on the role and function of MHC proteins in different laboratories around the globe. The articles in this book cover topics from the importance of MHC diversity to the health of the wildlife to intimate molecular mechanisms of MHC exchange between cells. This book will be useful to a wide range of scientists and clinicians who are working in the field of immunology, transplantation and cancer research.

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Book SynopsisThis book provides a descriptive analysis of the key issues regarding adverse events in hospitals. The term "adverse event" describes any harm to a patient as a result of medical care. An adverse event indicates that the care resulted in an undesirable clinical outcome and that the clinical outcome was not caused by an underlying disease. Research, policies, and action taken to reduce adverse events often focus on mistakes and systemic problems with care. However, adverse events do not always involve errors, negligence, or poor quality care and may not always be preventable.

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Book SynopsisThe incidence of gastric carcinoma is declining, but this form of cancer is still the fourth most common cause of malignancy world-wide and the second most common cause of cancer-related deaths. This book is structured in eleven chapters, written by acknowledged experts in the field of gastric cancer and includes the most interesting topics including surgical anatomy, clinical staging, analysis of prognostic factors in early and advanced stages, sentinel node biopsy results, surgical standard, laparoscopic and robotic techniques of gastrectomy with D2 lymphadenectomy, perioperative and postoperative complications, neoadjuvant and adjuvant therapies and preoperative, perioperative and postoperative nutrition. This book is proposed to be useful both for surgeons in training and experienced surgeons for its completeness and actuality of the treated topics.

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Book SynopsisTamoxifen was first approved in 1977 and up to now remains a noteworthy therapeutic weapon to treat mainly breast cancer. However, further considerations exist regarding the tamoxifen profile. This book discusses recent research and future perspectives in the tamoxifen field. The topics discussed include tamoxifen pharmacokinetics, pharmacodynamics, adverse effects, clinical indications, therapeutic drug monitoring, autophagy mechanisms, tamoxifen topical formulation and breast cancer risk prevention, the use of tamoxifen in an oestrogen-independent manner for various neoplasms (Hepatocellular carcinoma, renal cell carcinoma, high grade glioma), mechanisms of resistance, potential role of CYP2D6, tamoxifen and antidepressants interaction in a psychiatric view, obesity influence in tamoxifen treatment, electrical pulse-mediated tamoxifen delivery, and tamoxifen in melanoma treatment.

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Book SynopsisIn the past, cancer was considered a fatal disease due to the poor outcome of the patients and scarce possibilities of treatment. Decades later, a multimodal approach of therapy including surgery, conventional chemotherapy and radiotherapy has been applied with irregular success, making it the best known combination for survival at the early diagnostic stage, as well as having created a revolution in the field of oncology. This book describes approaches to be applied for the therapeutic management of patients with cancer. (Imprint: Nova Biomedical)"

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Book SynopsisNanotechnology has emerged as a key technology which has opened new vistas to find effective therapies for cancer. Nanomaterials are particularly promising candidates for early diagnosis of cancer cells. Several classes of nanomaterials, including dendritic and supramolecular polymers, carbon nanotubes, graphene and metal nanoparticles, have shown tremendous ability to recognise and destroy cancer cells in vivo. In this book, some of these novel systems and their potential applications in cancer therapy are reviewed.

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Book SynopsisThis book presents current research in the study of oesophageal cancer. Topics discussed include epidemiology and risk factors; helicobacter pylori infection and oesophageal cancer; celiac disease and the risk of oesophageal cancer; radiation therapy of oesophageal tumours; endoscopic ultrasound in oesophageal carcinoma; minimally invasive esophagectomy versus open techniques; esophagectomy for advanced stage esophageal cancer and surgical treatment of cervical oesophageal cancer.

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Book SynopsisGlioblastoma is the most common and lethal primary brain tumor which exhibits clinical, radiological and pathological heterogenity. Despite advances in standard therapy, including surgical resection, radiotherapy and chemotherapy, the prognosis for patients remains poor. In this book, the authors present topical research on the risk factors, diagnosis and treatment options for glioblastoma. Topics discussed include the therapeutic potential of scorpion toxins against glioblastoma; co-amplified oncogenes in glioblastoma; mesenchymal stem cells as a novel therapeutic delivery vehicle for glioblastoma; targeting fibroblast growth factor (FGF) signals and how to stop glial neoplastic brain development.

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Book SynopsisThis book presents original research results on the leading edge of cancer. Topics discussed include the aetiology and treatment of gallbladder cancer; HPV vaccine and cervical cancer; docetaxel therapy and applications; metastatic cancer pain management for the bone, spine and liver; the effects of cytoskeletal structure change induced by docetaxel on gene expression; nutrition and breast cancer; and docetaxel''s effect on ovarian function and in the management of patients with head and neck squamous cell carcinoma.

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Book SynopsisThis book consists of 16 chapters. The topics include the study of an application of Traditional Medicine (TM) to cancer care, a new anti-cancer TM drug without any strong side-effect, TM for chronic fatigue syndrome and viral hepatitis, mechanisms of licorice-induced pseudoaldosteronism, anti-tumour effects of gomisin A, interactions between TM drugs and Western drugs, pharmacoeconomic evaluations, primo vascular system, a sustainable approach to TM, and medical ethics. This book will open a new window to future research on TM.

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Book SynopsisThis book includes eight chapters of original research articles and six chapters of review articles, encompassing the latest advancements in detection, growth and treatment of prostate cancer. Detection of prostate cancer in human patients has been well established using prostate-specific antigen as a marker and a variety of imaging tools. However, for laboratory studies particularly in preclinical animal studies, such tools are still being developed. This book introduces novel imaging methods, such as bioluminescent imaging, chemiluminescence, and magnetic resonance imaging. Prostate cancer stem cells are emerging as a new focus of research. How to detect cancer stem cells and how to culture them are described in details herein. This book highlights several studies in exploring some unknown aspects of prostate cancer.

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Book SynopsisThis personal scientific memoir describes how a chance observation concerning artery disease in children with rare inherited abnormalities of metabolism, often called experiments of Nature, led to the discovery of a new theory of heart disease, cancer and diseases of ageing. As explained in subsequent chapters, this new theory places the amino acid homocysteine at the heart of altered metabolism of diseases of ageing. Not only does this theory illuminate and explain the origin of these diseases, development of this theory logically leads to a novel and revolutionary metabolic and nutritional program for disease prevention and treatment, potentially benefiting individuals and populations.

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Book SynopsisEndometrial cancer is the most common gynecological malignancy after breast cancer in developed countries. Its incidence is steadily rising and, now, the lifetime risk of developing endometrial cancer in the industrialized areas is about 23%. This book deals with the main aspects of disease management, including the perspectives for primary and secondary prevention, and the most recent interpretation of its pathogenesis. The management of endometrial cancer continues to evolve as we better understand tumour biology and more widely apply what evidence-based medicine comes from. This book may be of interest and a useful update for any health provider involved in gynaecological cancer care.

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Book SynopsisThis book aims to become a useful tool in the field of gynaecological oncology providing the most up-to-date research on non-epithelial ovarian tumours, including the recent data on pathogenesis and the current strategies for diagnosis, treatment, and follow-up. The authors present and review important data on rare and various primary ovarian neoplasms such as the many subtypes of germ cell tumours, of the most important subtypes of Sex cord -Stromal tumours and the rare mixed forms of Germ cell and Gonadal Stromal tumours. Non-specific mesenchymal tumours of the ovary are reviewed, as well as Secondary neoplasms, metastatic to the ovary from various sites (extragenital and genital primaries).

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Book SynopsisThis book presents original research results on the leading edge of cancer. Topics discussed include the role of dendritic cells in the priming of cytotoxic T lymphocyte responses; current anti-cancer agents targeting apoptosis and authophagy and clues for future cancer drug discovery; the efficacy of bufadienolides and TCM preparations on in vivo and in vivo cancer models in clinical trials; the role of tetracyclic triterpenes and their glycosides in cancer prevention; adoptive cell therapy at the forefront of cancer immunotherapy; the challenges and promises of targeted chemoprevention; the physical, emotional and social challenges associated with cancer survivorship; bioinformatics tools and resources for cancer diagnosis and drug development; and the history of radical surgery for the treatment of prostate cancer.

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Book SynopsisFrom the early 80s of the past century, clinical and epidemiological studies have increasingly pointed to an elevated breast, endometrial and ovarian cancer risk from high circulating oestrogen levels. Oestrogen deficiency as a cancer risk factor emerged first in 2007 in a study on Hungarian oral cancer cases based on the gender and age-related differences in tumour prevalence. Critical re-evaluation of the contradictory results of hormone replacement therapy yielded a complete conversion that oestrogen deficiency may confer cancer initiation. This book examines the deleterious interactions between oestrogen deficiency and further hormonal disorders which illuminate the apparently controversial associations of obesity, light exposure and alcohol intake with breast cancer risk.

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Book SynopsisIn this book, the biology, current treatment modalities and new emerging therapeutic approaches and targets for glioma, a highly aggressive and invasive brain tumour, are described. The pathologic features of the most frequently WHO classified gliomas encountered in clinical practice, are reviewed. Molecular genetics and specifically the mutations that underlie brain tumours are outlined as is the inherited genetic susceptibility and lifestyle risk factors reflecting on glioma epidemiology. The clinical features of glioma as well as diagnostic methods that include conventional and advanced magnetic resonance imaging (MRI) and brain mapping are also discussed with an outline of emerging treatment options.

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Book SynopsisCervical cancer (CC) is a major global health problem. World-wide, an estimated 530,000 new cases of CC and 275,000 deaths from this disease are encountered every year. CC affects particularly women less than 45 years of age and it is the leading cause of cancer-related deaths among women in the developing and underdeveloped countries, where 6080% of cases are detected in advanced stages. After Human Papillomavirus (HPV) identification as the infectious etiological agent and elucidation of the natural history of CC, this tumour has become the most preventable and curable of all cancers. Well-organised screening programs with Papanicolaou (Pap) smear are known to be successful in decreasing both mortality and morbidity of this disease. This book describes the optional screening programs for CC prevention, whether organised, opportunistic or spontaneous and also their merits and weaknesses. Monitoring of the pathways and procedures of CC screening are mandatory in order to minimise the risks (wrong diagnosis, over-diagnosis, over-treatment) and maximise the benefits. In an optimal setting, the women should be the focus of the screening intervention and receive basic information on the crucial points of CC screening, so as to improve women''s collaboration and compliance. The availability of alternative new screening tools to detect pre-cancer lesions provide new opportunities for CC prevention, as do HPV vaccines implemented in early life before viral exposure. This book, rich in pictures, tables and flowcharts is a comprehensive treatise on CC screening: its 14 chapters illustrate the fundamental principles and the necessary interventions for CC prevention and control and a guide for all medical and paramedical professionals involved in the interplay of CC screening.

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Book SynopsisAn oncogene is a modified gene, or a series of nucleotides that encode a protein, and direct the cell to the development of a neoplastic phenotype. Usually, oncogenes are involved in tumour development and increase the possibility that the development of a cell directs towards cancer. In this book, the authors present current research in the study of the classification, mechanisms of activation and role in cancer development of oncogenes. Topics include the role of oncogenes in gynaecological pathology; oncomirs as the next frontier of oncogenes affecting cancer aetiology and tumour progression; the role of the epidermal growth factor receptor as a therapeutic target in glioblastoma and other malignancies; and tumour suppressers involved in DNA repair and carcinoprevention.

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Book SynopsisThis book presents original research results on the leading edge of cancer. Topics discussed include coping mechanisms in patients with head and neck cancer; hepatocellular carcinoma; chronic lymphocytic leukaemia; the pathobiology of B-lymphoproliferative disorders from MBL to CLL to SLL; molecular and cellular characterisation of chronic lymphocytic leukemia; pain as a consequence in patients with early stage breast cancer treated with intracavity brachytherapy accelerated partial breast irradiation (IBAPBI); the future of anti-tumour immunotherapy; coping with childhood cancer; and the current clinical utility of Everolimus in the treatment of renal cell carcinoma.

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Book SynopsisGlobally, cervical cancer is the second leading cause of death for women with cancer. This is a tragedy in part because cervical cancer affects women usually a decade sooner than other cancers when those women are in their reproductive years and in the prime years in the labour force. While screening with the Pap test or other more recently evaluated tests have resulted in low cervical cancer rates in high resource countries, the lack of screening options in low resource countries means that many women present with symptoms reflective of advanced disease and so the chance of survival is low even with aggressive treatment. In this book, we have an international spectrum of authors from both high and low resource settings. We review the risk factors that lead to cervical cancer. We discuss novel screening techniques including HPV testing. We present the capacity for HPV vaccines to markedly reduce cervical cancer rates. Planning and implementing an organised cervical screening program and the assessment of quality indicators as a means of evaluation is outlined. In this book, we discuss novel operative options in early stage invasive cervical cancer as a means of preserving fertility. Also, we discuss the role of neoadjuvant chemotherapy as a means of down staging the disease. The role of surgically staging women to define more advanced disease is outlined including options for management of metastatic and/or recurrent disease with chemotherapy and targeted therapies. The special situation of women found to be pregnant during the diagnosis of pre-invasive or invasive cervical cancer; and the diagnosis and management principles are reviewed. Just as poliomyelitis has almost been eliminated in the lifetime of one generation, we look forward to the elimination of oncogenic HPV and its deadly ramifications particularly for women exposed to this virus.

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Book SynopsisThis monograph summarizes the data of the prospective study on the immunological characteristics of cancer patients with sepsis and septic shock developed after surgery. Patients without signs of infectious complications and symptoms of organ failure, as well as a group of healthy donors, were considered as references. The comparative analysis of blood parameters that characterized humoural and cell immunity (concentrations of cytokines and their receptors, immunoglobulins, lipopolysaccharide and other active biomolecules) has been performed. An estimation of diagnostic and prognostic significances of these parameters has been performed as well. In the final chapters, the properties of the new perspective hypercrosslinked polymeric hemosorbents are presented. The monograph could be interesting for a wide array of specialists in the fields of resuscitation, healthcare therapy, oncology and surgery, as well as for researchers aimed toward the development of new types of biocompatible materials.

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Book SynopsisTargeted therapy has revolutionised modern oncology practice and has completely changed the outcome of once universally fatal diseases like chronic myeloid leukaemia (CML). The last decade has witnessed significant advances in the management of CML, which has become more like a chronic disease. Written by experts in the field, this volume nicely describes the current knowledge of the pathophysiology, clinical features, and management of CML. It covers not only clinical topics but also the basic science underlying these practices. It will be of help to clinicians and basic scientists alike. In addition to the state of the art treatment of CML, this book also covers many uncommon but very important special topics like management of CML in pregnancy or with children, management of resistance to new tyrosine kinases and treatment of the advanced phase of the disease. Written to be easily digestible, patients will also be able to access important and universally useful information on CML (eg: diagnosis, symptoms and signs, and treatment). Some themes especially, including drug and food interactions of tyrosine kinase inhibitors (TKIs), CML treatment during pregnancy, advantages/disadvantages of the most commonly used TKIs, and bone marrow transplantation indications, will be of popular concern. This extensively referenced book therefore should be of great help to both novices and experts in the field.

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Book SynopsisDoxorubicin is a classical but useful anti-tumour agent. It is used for the treatment of a variety of malignancies including solid tumours and leukaemia due to its broad spectrum anti-tumour activity. It also has well known toxic side effects that must be minimised for its successful use clinically. This book discusses intraperitoneal doxorubicin; preclinical characterisation of the drug-delivery device DCBeads for transarterial chemoembolisation of doxorubicin and nemorubicin; doxorubicin-induced cardiomyopathy; advanced therapies of doxorubicin by carrier of drug delivery system or combined food components; and prevention and management of cariotoxicity.

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Book SynopsisThis book presents original research results on the leading edge of cancer. Topics discussed include one woman''s experience with the Gerson therapy for cancer; epigenetic upregulation or direct over-expression of miR-137 enhances anti-tumour activity of delphinidin for inducing apoptosis in human glioblastoma T98G cells; potentials and challenges of chip technologies in serum biomarker studies for personalised medicine of colorectal cancer; colon cancer; targeting hallmarks of cancer as current therapeutic strategy; and epigenetic regulation of cancer.

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Book SynopsisIn the Middle East, as in other countries in the developing world, there is now a wide acceptance that palliative care is an important public health issue that should be integrated into the mainstream of cancer care as well as other life-threatening diseases. Nowadays, it is recognised as a human right issue that patients and families have the right to receive this care. The WHO defined palliative care as the active total care of the patient''s body, mind and spirit; whereby health care providers need to evaluate and alleviate the patient''s physical, psychological and social distress. Such care encompasses a broad, multidisciplinary approach that includes both the family and the community and is provided in a range of settings, from the hospital, to the community health centre, to home. This unique and timely book captures the progress and vision of many dedicated groups throughout the Middle East and the USA who have been working to advocate for and develop palliative care services in the region. Each of the book''s chapters describes the efforts and challenges professionals have been experiencing as they address the palliative care needs of patients with life-limiting illnesses. Each country''s specific chapter details the current state of palliative care services and describes the various approaches that led to the development of a range of services in hospital-based sites to community and home-based care services.

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Book SynopsisParaneoplastic Syndromes (PNS) are a group of disorders that cause endocrinologic, hematologic, neurologic, and dermatologic manifestations of cancer. These conditions are not directly caused by tumour metastasis, but rather the malignancies produce hormones and other proteins which act to disrupt the body''s homeostasis, thereby causing symptoms. The neurological complications of PNS are the result of an immune response to tumour antigens. PNS have been associated with a variety of cancers, such as genitourinary, ovarian, and breast, but are most commonly associated with neuroendocrine tumours. These syndromes can even occur before the primary tumour is identified. Historically, these conditions were considered rare, but given the difficulties with diagnosis, the exact prevalence is unknown. This book focuses on the symptoms, diagnosis, and treatment of PNS. More specifically, it discusses current concepts in common PNS; cutaneous PNS and skin features of internal malignancy; PNS in patients with malignancies of the genitourinary tract; PNS polyneuropathies; the correction of cancer-related anemai with oxyresveratrol; and PNS associated with lung cancer.

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Book SynopsisHepatocellular carcinoma (HCC) is the most common disease in the primary malignant tumour of the liver. It is considered that the therapy for HCC is very troublesome because most of the HCC occur from the injured liver such as chronic hepatitis or cirrhosis. If the patients with HCC receive proper therapy for their stage of HCC and liver function, a long survival is expected. In this book, the up-to-date contents of aetiology, diagnosis techniques, and various kinds of therapies for HCC are described. This book is very helpful for the medical staff that takes care of the patients with HCC. The contents of this book include precise descriptions of the following: i) the aetiology and epidemiology of HCC, ii) the diagnosis technique of CT and MRI, and the indications and results of the treatments, ie: iii) radio-frequency ablation, iv) molecular-targeted therapy, v) surgical resection, vi) transplantation, vii) trans-arterial chemo-embolisation, and radiotherapy. In addition, viii) proton beam therapy is introduced, which is a less invasive therapy for localised HCC.

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Book SynopsisLeiomyosarcomas (LMS) are soft tissue tumours derived from smooth muscles cells, often in the uterus, retroperitoneum, skin, vessels, and bone. They are one of the most common types of sarcoma. Most leiomyosarcomas are sporadic, but may develop in the setting of genetic syndomes such as hereditary retinoblastoma and L-Fraumeni syndrome. Leiomyosarcomas may also be a result of radiation exposure; however, radiation-induced sarcomas are typically undifferentiated, fibrosarcomas or malignant peripheral nerve sheath tumors. Like other sarcomas, prognosis is worse with higher grade tumours. Although chemotherapy and radiation are sometimes used as adjuvant therapy, the mainstay of therapy, and the only chance for cure, is surgery. The management of LMS is especially complex when the tumour involves major blood vessels. This book discusses the diagnosis and treatments most effectively used for Leiomyosarcomas. It also provides insight on the specific areas that LMS is found and how it affects that area.

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Book SynopsisGastric cancer is one of the leading causes of malignancy-related deaths world-wide with differences in incidence and treatment patterns geographically. There is extensive ongoing research for a better understanding of the cancer pathology and finding newer treatments. Advancements in basic science research are being translated for improving gastric cancer patient care. This book discusses an extensive array of different topics on gastric cancer in which strides of improvement have been achieved. The contributors of each specialised chapter of the book are leaders in their field and have been recognised for their work globally. This book aims to bring the readers up to date about all aspects of gastric cancer - from basic science research about animal models of gastric cancer, to pathophysiology, staging systems, different adjuvant therapies and surgical treatment options for gastric cancer. The newer treatment options of endoscopic mucosal resections and bursectomy are described in detail. The current statuses, debates and ongoing controversies in addition to the advancements on different aspects of gastric cancer research are discussed. The book is an invaluable resource of information on all aspects of gastric cancer with the latest advancements.

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Book SynopsisThis book is a guide for individuals who need to support patients with advanced cancer. It discusses treatment options such as palliative care, clinical trials, hospice care, and home care, as well as symptom control. It also addresses emotional concerns including feelings, communicating with friends and family, and living life to its fullest and with meaning. Lists of federal and non-profit organisations are provided that may be helpful in giving information and services to cancer patients. This book also explores many of the questions and crossroads that face caregivers when their loved one has been told that he or she has advanced cancer that is no longer responding to treatment.

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