Oncology Books

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Book SynopsisPrimary bone tumours are tumours that start in the bone. In contrast, secondary bone cancer is where the cancer started in another part of the body but has then spread to the bones. The most common types of primary bone tumor are osteosarcoma and Ewing''s sarcoma, both of which are most frequently diagnosed in children and young adults. Other less common types of bone cancer include: Chondrosarcoma (a cancer arising in cartilage cells, usually found in adults between ages 50-75, though the less common mesenchymal-chondrosarcoma is more frequent in younger patients), Malignant Fibrous Histiocytoma of bone (MFH), Chondoma (a rare low grade malignancy occurring mostly between ages 30 -70), and other rare tumours. This new book brings together leading research from throughout the world in this important area of research.

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Book SynopsisThyroid cancer is cancer of the thyroid gland. These may be of many types including papillary, follicular, Hurthle cell (aka oxyphilic or oncocytic), or medullary cancers. Surgery plays an important role in treating these cancers. The thyroid concentrates iodine and so is extremely sensitive to the effects of various radioactive isotopes of iodine produced by nuclear fission. These radioactive isotopes increase the chances of developing cancer, though thyroid cancer can develop even without any exposure to radioactivity. Some evidence suggests that insufficient or excessive dietary iodine may also increase the risk for thyroid cancer. This new book presents the latest research in this field.

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Book SynopsisThyroid cancer is cancer of the thyroid gland. These may be of many types including papillary, follicular, Hurthle cell (aka oxyphilic or oncocytic), or medullary cancers. Surgery plays an important role in treating these cancers. The thyroid concentrates iodine and so is extremely sensitive to the effects of various radioactive isotopes of iodine produced by nuclear fission. These radioactive isotopes increase the chances of developing cancer, though thyroid cancer can develop even without any exposure to radioactivity. Some evidence suggests that insufficient or excessive dietary iodine may also increase the risk for thyroid cancer. This book presents the latest research in this field.

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Book SynopsisThere are two types of brain tumours: primary brain tumours that originate in the brain and metastatic (secondary) brain tumours that originate from cancer cells that have migrated from other parts of the body. Primary brain cancer rarely spreads beyond the central nervous system, and death results from uncontrolled tumour growth within the limited space of the skull. Metastatic brain cancer indicates advanced disease and has a poor prognosis. Primary brain tumours can be cancerous or non-cancerous. Both types take up space in the brain and may cause serious symptoms (eg: vision or hearing loss) and complications (eg: stroke). All cancerous brain tumours are life threatening (malignant) because they have an aggressive and invasive nature. A non-cancerous primary brain tumour is life threatening when it compromises vital structures (eg: an artery). In the United States, the annual incidence of brain cancer generally is 15-20 cases per 100,000 people. Brain cancer is the leading cause of cancer-related death in patients younger than 35. This new book brings together the leading research in this dynamic area of research.

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Book SynopsisThree types of skin cancer account for nearly 100% of all diagnosed cases. Each of these three cancers begins in a different type of cell within the skin, and each cancer is named for the type of cell in which it begins. Skin cancers are divided into one of two classes -- non-melanoma skin cancers and melanoma. Melanoma is the deadliest form of skin cancer. The different types of skin cancer are: Basal cell carcinoma (BCC); Squamous cell carcinoma (SCC); Melanoma. All other skin cancers combined account for less than 1% of diagnosed cases. These are classified as non-melanoma skin cancers and include Merkel cell carcinoma, dermatofibromasarcoma protuberans, Paget''s disease and cutaneous T-cell lymphoma. This book examines the latest research in this field.

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Book SynopsisCancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures. This book brings together important research from around the world in this frontal field.

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Book SynopsisNeuroblastoma is a cancer that develops from nerve cells found in several areas of the body. Neuroblastoma most commonly affects children age 5 or younger, though it may rarely occur in older children and adults. Neuroblastoma is the most common cancer in babies. Neuroblastoma develops in tissue that makes up the sympathetic nervous system -- the system of nerves that automatically regulates your heart rate, blood pressure and digestion. Neuroblastoma most commonly arises in and around the adrenal glands, which sit atop the kidneys. However, Neuroblastoma can also develop in other areas of the abdomen and in the chest, neck and pelvis. This book presents important research in this field of research.

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Book SynopsisThis book presents an in-depth overview of the medical, psychosocial and sexuality issues that confront women affected by cancer.

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Book SynopsisThe world of experimental leukaemia research is a miniature of cancer research. Cancer research started from experimental leukaemia/sarcoma research of Ellermann and Bang and Peyton Rous in early 1900s. Experimental leukaemia includes most of important elements of cancer research; both viral and chemical carcinogenesis; most of important oncogenes and suppresser genes and the related cell biology. The author has added only a few sections such as skin carcinogenesis done by Yamagiwa and Berenblum and DNA viruses from outside of experimental leukaemia. By doing this, this book covers most of important topics of modern oncology, except researches done on human cancers. In this book, the author has arranged the chapters to contrast the pioneer works by Peyton Rous, Jacob Furth, and Ludwik Gross, etc, done more than half a century ago and the recent works by molecular biologists. Although the former pathologists provided various experimental materials, faced to severe criticism by contemporary researchers and they had tough hearts to cope with them, molecular biologists solved questions on these materials step by step by disclosing the invisible molecular events as a visible charts, molecular diagrams, or 3-D models just as magicians do. Experimental leukaemia has always afforded the key materials for solution of cancer. In experimental leukaemia, mutations and genetic recombination play an important role. They include ras gene mutations, insertional mutagenesis and gene transduction by retroviruses, recombination among retroviruses, and chromosome translocations. Most of them occur in highly specific genomic sites. However, the reason for the specificity in target sites remained obscure. The author was especially interested in the common target genomic sites for chemical carcinogens and retroviruses. Therefore the common pathway for retroviruses and chemicals became one of the main topics of this book.

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Book SynopsisThis book presents new and important research on precancerous conditions. A precancerous condition is a disease, syndrome, or finding that, if left untreated, may lead to cancer. These include: Cervix Dysplasia; Erythroplasia; Leukoplakia; Lymphomatoid Granulomatosis; Lymphomatoid Papulosis; Preleukemia; Xeroderma Pigmentosum. The identification and treatment of precancerous conditions on a wide-scale could lead to significant drops in deaths due to cancer.

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Book SynopsisThe spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors'' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.

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Book SynopsisCancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasises), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book presents leading-edge research from around the world.

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Book SynopsisBreast cancer is a malignant tumour that has developed from cells of the breast. A malignant tumour is a group of cancer cells that may invade surrounding tissues or spread (metastasize) to distant areas of the body. The disease occurs almost entirely in women, but men can get it as well. The main types of breast cancer are ductal carcinoma in situ, invasive ductal carcinoma, lobular carcinoma in situ, invasive lobular carcinoma, medullary carcinoma, and Paget''s disease of the nipple . About 1 of 8 women will get it in her lifetime. This book presents the latest research in this field.

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Book SynopsisThis multiauthored book describes the maglinant tumour, mesothelioma, and the latest advances in the field. Its purpose is to offer a comprehensive and up-to-date overview of epidemiology, molecular biology, pathology, animal model, diagnosis and therapy of human mesothelioma. This disease has become an international problem due to environmental ambient pollution, and lack of effective therapies. Notwithstanding the rise in interest in this disease at the scientific, clinical and medicolegal level, there are very few textbooks addressing mesothelioma, and even less books completely dedicated to this maglinant tumour.

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Book SynopsisTumourigenesis is the formation of tumours in the body, often caused by oncogenes. These tumours are the result of uncontrollable reproduction (cell division) due to alterations in the cell''s genetic code, creating lesions in the tissue where they reside. Tumourigenesis can be divided into tumour initiation, promotion and progression. Oncogenomics often studies tumours caused by such a condition in hope of pinpointing genes -- pieces of genetic information -- that are susceptible to being changed (mutated) by external factors like ultraviolet light, toxic chemicals, and other carcinogens. The range of normal genetic alterations that a person''s DNA undergoes over time is extraordinarily large, so it is hard to detect exactly what cause tumourigenesis. This book presents the latest research advances in the field.

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Book SynopsisGenes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it''s the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person''s cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This book offers important research from around the globe dedicated to this dynamic subject.

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Book SynopsisCancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastases), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book presents new research of importance to the field.

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Book SynopsisThe subject of matter of this book presents an interface between radiation biology and medicine and concerns knowledge and experiences obtained mostly in the last two decades in the field. The data are based on the chemical and biological effects induced by high-energy radiation in aqueous systems of vitamins and cytostatica as well as mixtures of both.The reducing and oxidising free radicals in the human organism are governing the various biological processes. They can also be produced by ionising radiation in each desired kind, a concentration in aqueous systems. Based on this fact, it is possible to perform appropriate studies in order to gain a deeper insight in the very complicated and fast biological processes. The purpose of this is to present, for the first time in a book, a critical scientific overview of the published radiation-induced antitumour-effects of vitamins and related substance as an anti-tumour agent.

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Book SynopsisToday, cancer is the second most prevalent cause of death, after heart disease, in the industrialised world. Till now, and despite promising results in cancer research, the primary cause of death in cancer is still 1: the formation of metastases at distant organs sites, 2: the presence of cancer cells that are resistant to current cancer therapies (chemotherapy/radiation) and which cause cancer relapse. Within the past three years it became evident that also solid tumour tissues contain a kind of stem cells, so called cancer cells. These cancer stem cells have been described as chemo-radiation therapy resistant tumour initiating cells. The purpose of this book is to summarise the latest findings about the role of stem cells in cancer.

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Book SynopsisThis book brings together new and important research on cancer prevention. Much of the promise for cancer prevention comes from observational epidemiologic studies that show associations between modifiable lifestyle factors or environmental exposures and specific cancers. Evidence is now emerging from randomised controlled trials designed to test whether interventions suggested by the epidemiologic studies, as well as leads based on laboratory research, result in reduced cancer incidence and mortality. The most consistent finding, over decades of research is the strong association between tobacco use and cancers of many sites. Hundreds of epidemiologic studies have confirmed this association. Further support comes from the fact that lung cancer death rates in the United States have mirrored smoking patterns with increases in smoking followed by dramatic increases in lung cancer death rates, and more recently decreases in smoking followed by decreases in lung cancer death rates in men. Infections may also be associated with cancer development. Human papillomavirus (HPV) infection is a necessary event for subsequent cervix cancer, and vaccine-conferred immunity results in a marked decrease in precancerous lesions. Likewise, Epstein-Barr virus has been associated with Burkitt lymphoma and Helicobacter pylori with gastric cancer, although specific anti-infective interventions have not yet proven effective in preventing these cancers. Additional examples of modifiable cancer risk factors include alcohol consumption (associated with increased risk of oral, oesophageal, breast, and other cancers), physical inactivity (associated with increased risk of colon, breast, and possibly other cancers), and obesity (associated with colon, breast, endometrial, and possibly other cancers). Observational evidence shows associations between alcohol consumption, physical inactivity, and obesity and increased incidence of certain cancers. More research is needed to determine whether these associations are causal and whether avoiding these behaviours would actually reduce cancer incidence. Other lifestyle and environmental factors known to affect cancer risk (either beneficially or detrimentally) include certain sexual and reproductive practices, the use of exogenous estrogens, exposure to ionising radiation and ultraviolet radiation, certain occupational and chemical exposures, and infectious agents. Food and nutrient intake have been and are being examined in relation to many types of cancer.

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Book SynopsisOral Cancer is a neoplasm with a fairly large male to female ration in most populations. Moreover, it develops in older age in females in comparison with males, and the ration of non-smokers, non-drinkers among elderly female oral cancer cases if suprisingly high. The conspicuously lower incidence of this tumour among women than men is suggestive of certain endocrine involvement in its development. There are no available literary data as yet which would give an explanation to this gender specific incidence of oral cancer. Oral cancer is a multicasual disease and there are thorough interrelationships among the etiologic factors. Till now, exogenous harmful noxae (tobacco, alcohol comsumption and energy rich diet) were overemphasised in its epidemology. However, these exogenous factors have not only local carcinogenic effect in the oral cavity, but also induce systemtic changes by means of metabolic and hormonal pathways. With full knowledge of these correlations, isolated investigations of exogenous risk factors may be misleading. This book containing the author''s results on oral cancer raises a new concept concerning tumour initiation. Not oestrogen, but its deficiency may provoke malignant transformation. This new theory may explain many controversial literary data concerning the associations of female sexual steroids and malignancies.

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Book SynopsisCancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasises), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book presents new research of importance to the field.

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Book SynopsisBreast cancer is the most frequently diagnosed type of cancer and a second leading cause of cancer death in women after lung cancer. Despite their proven efficacy, classical therapies are, however, unable to cure metastatic breast cancer and are often associated with significant toxicity and side-effects, due to a wide spectrum of action. During the last years, our increasing knowledge of the molecular pathways underlying cancer development has led to the introduction of new drugs, of which most are directed towards very specific targets. Rather than to be used as single agents, these "modern" compounds could ultimately be combined with classical molecules. Here are described nearly 150 drugs that are currently used in routine therapy or are in clinical trials in breast cancer patients. From the classical tamoxifen, fluorouracil, cyclophosphamide, doxorubicin, epirubin, docetaxel, paclitaxel..., to the more recently introduced ixabepilone, lapatinib, vorinostat, everolimus, bevacizumab..., they also include capecitabine, gemcitabine, trastuzumab, bevacizumab, fulvestrant, aromatase inhibitors, cancer vaccines, inhibitors of tumour-induced osteolysis, insulin-like growth factor-I receptor inhibitors, poly(ADP-ribose) polymerase (PARP)-1 inhibitors, and many others. This book offers an insight into current developments of breast cancer therapy, when classicism meets modernity.

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Book SynopsisMultiple myeloma (also known as myeloma or plasma cell myeloma) is a progressive hematologic disease. It is a cancer of the plasma cell, an important part of the immune system that produces immunoglobulins (antibodies) to help fight infection and disease. Multiple myeloma is characterised by excessive numbers of abnormal plasma cells in the bone marrow and overproduction of intact monoclonal immunoglobulin or Bence-Jones protein. Hypercalcemia, anaemia, renal damage, increased susceptibility to bacterial infection, and impaired production of normal immunoglobulin are common clinical manifestations of multiple myeloma. It is often also characterised by diffuse osteoporosis, usually in the pelvis, spine, ribs, and skull. This new book gathers the latest research from around the globe on multiple myeloma research and related topics such as immune defects in multiple myeloma, surgical options in the treatment of spinal myeloma, the role of PBSC in multiple myeloma and allogeneic stem cell transplantation.

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Book SynopsisBreast cancer is the most common cause of cancer in women and the second most common cause of cancer death in women in the U.S. While the majority of new breast cancers are diagnosed as a result of an abnormality seen on a mammogram, a lump or change in consistency of the breast tissue can also be a warning sign of the disease. Heightened awareness of breast cancer risk in the past decades has led to an increase in the number of women undergoing mammography for screening, leading to detection of cancers in earlier stages and a resultant improvement in survival rates. Still, breast cancer is the most common cause of death in women between the ages of 45 and 55.This book presents the latest research in the field.

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Book SynopsisHorizons in Cancer Research presents original research results on the leading edge of cancer. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. This book presents the latest research in the field of cancer research, including a global overview on cancer biology; increased risk of cancer with exposure to chemical pollutants; organotin-containing polyethers as anticancer drugs; and stem cell and gene therapy as potential treatment applications.

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Book SynopsisThis book gathers current research from across the globe in the study of brain cancer, cervical cancer and tumour targeting. Some topics discussed in this compilation include emerging targets in cancer therapy and novel nanotechnology-based therapeutic strategies that have been changing the paradigm in cancer treatment; laparascopy and robotics in cervical cancer treatment; the history and current status of glioma therapy and glioma gene therapy; congenital tumours of the central nervous system; a review of tumours of the paranasal sinuses and real-time tumour targeting in external beam radiotherapy.

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Book SynopsisThis book reviews the world literature on elapsed times in the management of early breast cancer, with a particular focus on an amazingly wide variety of Canadian studies assessing elapsed times. This book presents and discusses a new technique called the "multi-interval, multi-resolution analytic framework", which examines the relationship among all care intervals in relation to predictors of longer relapse times along the care path. Most strikingly this technique shows that elapsed times in general have increased over the last five to ten years, probably related to legitimately increased indications for radiation, chemotherapy and biologic therapies

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Book SynopsisThis book presents and discusses research in the study of breast cancer diagnosis and prevention. Topics discussed include strategies for the prevention of breast cancer; health benefits and breast cancer screenings; access to mammography facilities; the reduction in the risk of human breast cancer by selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer perceptions and knowledge among women living in a rural community.

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Book SynopsisThis book examines the causes, diagnoses and treatment of oral cancer. Topics discussed include the role of MRI and DCE-MRI in the differential diagnosis of squamous cell carcinomas, salivary gland tumours and malignant lymphoma; radiotherapy for oral cancer; chewing tobacco and oral cancer; tumour suppressor gene detection in oral tumours for new therapeutic strategy; innate immunity and oral carcinogenesis and salivary metabolomics for oral cancer detection.

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Book SynopsisThis book presents and discusses current research in the study of cancer prevention. Topics discussed include the etiological models of prostate cancer; in vitro evidence of Kaposi''s sarcoma associated herpesvirus reactivation by corticosteroids; role of immunoregulators in nitric oxide production; a prooxidant mechanism of red wine polyphenols in chemoprevention of cancer; fas-resistance in adult t-cell leukaemia lymphoma and cancer prevention through nutrition education in the workplace.

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Book SynopsisThe significant advances in medical, surgical and social care during the last two decades in the western world have resulted in a considerable prolongation of life expectancy. However, on the other hand, aged populations present a high incidence of neoplasias ideally requiring surgical or multidisciplinary therapeutic strategies. The decision making for providing the appropriate surgical care in these patients is a difficult and multivariant task. This book examines cancer surgery in elderly patients, as well as a need for a more ''personalised'' approach and a thorough discussion of their disease treatment and status of life.

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Book SynopsisOpen surgical biopsy is the "gold standard" or "reference standard" method of evaluating a suspicious breast lesion because it is thought to be very accurate in diagnosing these lesions. While generally considered safe, it is a surgical procedure that, like all surgeries, places the patient at risk of experiencing morbidities and, in rare cases, mortality. However, only 20 to 30 percent of women who undergo breast biopsy procedures are diagnosed with cancer. A less invasive method for evaluation of suspicious breast lesions would be preferable if it were sufficiently accurate. This book examines the effectiveness of core-needle and open-surgical biopsy in breast cancer evaluation.

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Book SynopsisMelanomas are usually highly proliferative, invasive and are most frequently metastatic. Melanoma accounts for nearly 4% of skin cancer cases but, because of its highly metastatic capability, for 74% of all skin cancer mortalities. Therefore, melanoma is one of the deadliest forms of cancer and its treatment continues to be challenging. This book presents topical research in the study of the symptoms, diagnoses and treatment of metastatic melanoma. Topics discussed include new therapeutic alternatives for melanoma; the metastatic cascade and experimental treatments; pediatric melanoma and the relative risk of metastatic melanoma.

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Book Synopsis"Horizons in Cancer Research" presents original research results on the leading edge of cancer. Topics discussed include the treatment of brain metastasis with radiotherapy; distant metastasis, DNA methylation profiling to identify known and novel tumour subtypes; breast cancer imaging; antimetastatic treatment approaches in the clinic; laryngeal carcinoma classification of pancreatic cancer and vaginal carcinoma.

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Book SynopsisLung cancer is one of the leading causes of death world-wide with the majority of patients suffering from advanced unresectable or metastatic non-small cell lung cancer. Despite the advances in palliative chemotherapy, the survival rate for patients with this advanced disease treated with chemotherapy remains poor. In this book, the authors present topical research in the study of lung cancer treatments including epidermal growth factor tyrosine kinase inhibitors, in the management of advanced stage non-small cell lung cancer; lung cancer brachytherapy; volumetric modulated arc therapy and future individualised therapy for lung cancer in post-genomic era.

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Book SynopsisThis book presents current research in the biology, diagnosis and treatment of cancer. Topics discussed include breast cancer knowledge, risk factors and screenings; uterine neoplasms; dendritic cell immunotherapy for the treatment of malignant melanoma; role of effectors on hypoxia due to nitric oxide production in human alveolar epithelial cells; complementary and alternative medicine approaches in the treatment of cancer; intrinsic and extrinsic mechanisms of drug resistance and adjuvant chemotherapy for resected colorectal cancer.

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Book Synopsis"Horizons in Cancer Research" presents original research results on the leading edge of cancer. Topics discussed include prostate cancer biomarkers and proteomic techniques; organ sparing radiation therapy for head and neck cancer; pain assessment in clinical trials of anticancer treatments; invasive epithelial ovarian cancer pathogenesis; the role of type I insulin-like growth factor receptor in prostate cancer; pain in advanced prostate cancer; role of brachytherapy ablation in cancer pain management and cancer screening in neonatology.

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