Neurology and clinical neurophysiology Books
Johns Hopkins University Press Central Neural States Relating Sex and Pain
Book SynopsisHormones strongly influence and even drive certain primitive behaviors. In Central Neural States Relating Sex and Pain, Richard J. Bodnar, Kathryn Commons, and Donald W. Pfaff examine hormonal, neural, and genetic mechanisms of reproductive, pain-sensing, and pain-inhibitory systems. The authors show that there are remarkable neuroanatomical, biochemical, and functional overlaps among these systems. They consider sensory inputs triggering both classes of behaviors and focus on the role of sex hormones in modulating both forms of behavior. Sex hormones acting in different regions of the brain not only energize reproductive behaviors but also modulate opioid-dependent pain-inhibitory pathways. The authors also summarize some intriguing gender differences in hormone actions and responsivity to pain.The clinical implications of this field of research are numerous. Central Neural States Relating Sex and Pain will appeal to anyone interested in new ways of looking at behavioral dispositions as they are influenced by specific genetic, neural, and hormonal states.Table of ContentsContents: Series Foreword Preface List of Abbreviations I Requirement for Motivational State Concepts A Physics, Brain, and Behavior B Motivation in Its Generalized and Specific Aspects C Motivation for Females to Seek Males D Hypothalamic and Preoptic Mechanisms Involved in Two Types of Motivational Change E Summary II Ascending Arousal Systems Activated A Ascending Reticular Activating Systems B Structure of Arousal States C Application to Sexual Behavior D Clinical Observations on Human Awareness and Arousal E Mood F Summary III Descending Systems: The Importance of Opioid Peptides and Analgesia A Opioid Peptides in Pain and Analgesia B Analgesia Induced by Stress and Environmental Variables C Hormonal Control of the Enkephalin Gene: One Paradox and Three Solutions D Intimate Relations among Inhibitory Systems E Hypothalamic Projections F Gender Differences in Analgesia G Pain and Sex: Similarity of Reproductive Behavior and Analgesia - Ascending and Descending Pathways H Summary IV Inferences and Arguments A Gene/Behavior Relationships: Application to Opioid Peptides B Biological Importance of the Relations among Sex, Arousal, and Analgesia References Index
£56.95
University of Nebraska Press Modern Art at the Border of Mind and Brain
Book SynopsisHuman beings have made images continuously for more than thirty thousand years. The oldest known cave paintings are between six and ten times older than the first forms of written language. Images help us organize our thoughts and represent them in our memory. We make images, Jonathan Fineberg argues, because we need them to aid not only in structuring our social and psychological self-conceptions but also in developing the circuitry of our brains.Modern Art at the Border of Mind and Brain is a broad investigation by one of the foremost scholars of modern art of the relationship between modern art and the structure of the mind and brain. Based on Fineberg's Presidential Lectures at the University of Nebraska, his book examines the relationship between artistic production, neuroscience, and the way we make meaning in form. Drawing on the art of Robert Motherwell, Joan Miró, Alexander Calder, Christo, Jean Dubuffet, and others, Fineberg helps us understandTrade Review"Based on Fineberg's reputation, it could be expected that Modern Art at the Border of Mind and Brain would be a valuable addition for collections centered on art theory. But it's what makes this book special–its text and visuals–that extends its appropriateness into general art collections."—Carl Schmitz, Art Libraries Society of North America“This is your brain. This is your brain on art. Jonathan Fineberg shows us just how art’s very ambiguity and subjectivity enables the brain to adapt and grow in ways that help us navigate our brave new multiverse. His book is an endlessly fascinating account of the mechanics of our perceptions when confronted with the ruptures of the new. It’s a wild ride!”—Fred Tomaselli, artist, New York “‘Art, like falling in love, simultaneously disorganizes and nurtures the self toward a creative reordering,’ writes Fineberg. It’s hard not to love his book, informed by fifty years of writing about art and intelligently engaging neuroscience and psychoanalysis to make a case for the fundamental importance of art. With elegant and concise prose the author crafts a particularly eloquent argument for the power of abstract art as an articulation of thought in form. Looking at art allows us to confront the new and bewildering. Seeing literally alters our brains.”—Dorothy Kosinski, director of the Phillips Collection, Washington DC“Don’t be deceived by the brevity of this book. In it Jonathan Fineberg gives a thrilling and inspiring account of the fundamental problem in abstract art: the representation of visual forms. It should be must-reading for all who are interested in neuroesthetics and the elusive problem of form representation.”—Semir Zeki, professor of neuroesthetics at University College London, Fellow of the Royal Society, and author of Splendors and Miseries of the Brain Table of ContentsForewordIntroduction1. Motherwell’s Mother: An Iconography in Abstraction2. The Ineffable, the Unspeakable, and the Inspirational: A Grammar3. The Nature Theater: Art and Politics4. Desire Lines in the MindEpilogueAcknowledgmentsNotesIndex
£27.90
University of Nebraska Press Get Me Through Tomorrow
Book SynopsisTrade Review"A heartfelt memoir of devotion and determination."—Kirkus“A profoundly moving story about the unbreakable bond between siblings, and a beautifully written testament to the tremendous healing power of love.”—Mira Bartók, author of The Memory Palace “With candor and a sister’s love, Mojie Crigler has written a lyrical account of her brother’s brain injury and their family’s heroic efforts to find a path to recovery. Get Me Through Tomorrow should be read by all who aspire to make the care of these patients more humane and effective.” —Joseph J. Fins, MD, MACP, Weill Cornell Medical College, and author of Rights Come to Mind: Brain Injury, Ethics, and the Struggle for Consciousness Table of ContentsNo TOC
£15.19
Stanford University Press MapSeeking Circuits in Visual Cognition
Book SynopsisThis work presents a bold new theory of the cognitive circuitry of the brain, with emphasis on the functioning of human vision. The author has developed a computational theory that provides a unitary explanation for a wide range of visual capabilities and behaviors, most of which have no accepted theoretical explanation.Trade Review“What Arathorn has done is brilliant. The question of how the brain forms representations of objects which are invariant to changes in position, size, viewing angle, etc. is a deep and mysterious one, and he has come up with a clever solution based on remapping input patterns using a neural network. It provides the beginnings of a framework for thinking about visual cognition in neural terms, something that is sorely needed in the field.”—Bruno Olshausen, University of California, Davis
£52.20
Rutgers University Press Neuropharmacotherapy in Critical Illness
Book SynopsisIn the treatment of neurocritical disease states, pharmacotherapeutic strategies are increasingly relevant. This is the first book to provide this information in a high-yield format for the busy healthcare provider. This book provides practitioners with clinical pearls on neuropharmacology, dosing strategies, monitoring, adverse events, drug interactions, and evidence-based pharmacotherapy.Table of ContentsTABLE OF CONTENTS 1. Hyperosmolar Therapy in Traumatic Brain InjuryH. Gibbs, J. Garcia, and R. Neyens 2. Sedation and Neuromuscular Blockade for Neurocritical Care PatientsK. Chester and K. Greene 3. Antithrombotic Therapy for Ischemic StrokeE.P. Tesoro and E. Durr 4. Coagulopathy Reversal Agents for Intracranial HemorrhageK. Berger, N.G. Panos, and J.J. Lewin III 5. Pharmacotherapy for Cerebral Vasospasm Prophylaxis and Treatment in Subarachnoid HemorrhageD.H. Rhoney, K. Morbitzer, and J. Hatton-Kolpek 6. Pharmacotherapy of Acute Spinal Cord InjuryK. Bledsoe and C. Morrison 7. Hemodynamic ManagementT.A. Allison and A. Castle 8. Antiepileptic Agents for the Prevention and Treatment of SeizuresA.M. Cook, N. Liang, and V. Nguyen 9. Neuropharmacologic Therapies for Recovery Following Traumatic Brain Injury and Ischemic StrokeA. Shaun Rowe and L. Kurczewski 10. Intracerebroventricular and Intrathecal Drug TherapiesT. Human, J. Bushwitz, and O. Falana Index
£99.20
MP-VIR Uni of Virginia Nervous Fictions Literary Form and the Enlightenment Origins of Neuroscience
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£37.00
New York University Press Essential Papers on Masochism
Book SynopsisThe contested psychoanalytic concept of masochism has served to open up pathways into less-explored regions of the human mind and behavior. Part of the "Essential Papers in Psychoanalysis" series, this title presents an anthology of writings in the psychoanalytic study of masochism.
£59.50
University of Pittsburgh Press Medicine and Modernism A Biography of Henry Head Sci Culture in the Nineteenth Century
Book SynopsisAn in-depth study of the English neurologist and polymath Sir Henry Head (1861-1940). Head bridged the gap between science and the arts. He was a published poet who had close links with such figures as Thomas Hardy and Siegfried Sassoon. His research into the nervous system and the relationship between language and the brain broke new ground.Trade Review"Will captivate doctors, medical historians and anyone interested in the shift from Victorian to twentieth century." —Medical History|"Jacyna's seminal portrait of physiologist-turned-clinical-neurologist Henry Head reinvents medical biography and positions it at the cutting edge of several rejuvenated historiographies." —British Journal for the History of Science|"This is a thoughtful, critical—and oftentimes compassionate—view of an overlooked figure of the modernist period." —The British Society for Literature and Science|"Medicine and Modernism is as impressively polymathic as its subject . . . Jacyna is a consummate historian, faithful to the detail of Head's life that emerges from a rich archive of material, both published and unpublished." —Modernism-Modernity|"Jacyna has given us an accomplished, scholarly, and insightful account of an era." —Brain|"Jacyna is a highly regarded historian of medicine who . . . has written an eloquent and subtle biography of an individual and his milieu. It will be of interest to anyone seeking a window on to the world of medicine and the arts at the outset of the twentieth century." —Aphasiology
£42.75
Fordham University Press Stroke Book The Diary of a Blindspot
Book Synopsis
£40.50
John Wiley & Sons Inc Understanding the Nervous System
Book SynopsisProviding a fascinating alternative to the unwieldy life science sources, this book describes how the nervous system (including the brain) communicates with, sends signals to, and receives input from the sensory organs. Starting with the basic principles and components of the nervous system with sensory receptors, neurons and dendrites, and the skeletal muscle circuits the authors unfold the mystery of this communication with simple, elegant mathematical formulas to enhance your understanding of how the nervous system functions in complicated auditory and visual systems, and the brain. Includes extensive references at the end of each chapter! Sponsored by: IEEE Engineering in Medicine and Biology SocietyTable of ContentsPreface. Excitable Tissue. Sensory Receptors. Generation of the Action Potential. Propagation of the Action Potential. Dendritic Summation. Lateral Inhibition. Simple Neuronal Systems. Skeletal Muscle Circuits. The Auditory System. The Eye as a Transducer. Visual Pattern Recognition, Neural Networks, and "Household Chores". About the Brain. Index.
£85.46
John Wiley and Sons Ltd Birth Asphyxia and the Brain
Book SynopsisThis text presents a state-of-the-art review of asphyxial brain injury to the foetus and new born, a leading source of both neonatal mortality and long-term neurologic disability. Beginning with an historical overview of birth-related injury, followed by an epidemiologic review of the relationship of birth injury to later neuromotor disability, it provides a detailed analysis and exhaustive review of each aspect. The contributors are among the most knowledgeable international authorities in the field; they have synthesized a uniformity of medical and scientific quality, clarity of style, and thoroughness of scope. Continual emphasis is placed on the material''s relevance and usefulness to clinicians; equally important is the emphasis on communication between clinicians and basic neuroscientists. The task of paediatricians and neonatologists in coming years will be to better understand the mechanism of brain damage, the prediction of disability, and the introduction of efficacious neTable of ContentsForeword. Harvey B. Sarnat. Part I. History and Epidemiology. Chapter 1. Cerebral Palsy and Its Causes: Historical Perspectives. Tonse N.K. Raju. Chapter 2. The Relationship of Birth Asphyxia to Later Motor Disability. Michael P. Collins, Nigel S. Paneth. . Part II. Basic Science. . Chapter 3. The Biochemical Neurotoxic Cascade in Hypoxic-Ischemic Injury. Michael V. Johnston, Akira Ishida, Wako Nakajima, William Trescher. Chapter 4. Inflammation and Neonatal Brain Injury. John D.E. Barks, Faye S. Silverstein. Chapter 5. Glucose, Acidosis, and the Developing Brain. Robert C. Vannucci, Susan J. Vannucci. Chapter 6. Energy Consequences of Cerebral Hypoxia-Ischemia. John S. Wyatt. Chapter 7. Apoptosis and Necrosis in Perinatal Brain Injury. Huseyin Mehmet, A. David Edwards. Chapter 8. Effects of Nitric Oxide on Neuronal and Cerebrovascular Function. Donna M. Ferriero, Stephen Ashwal. Chapter 9. Free Radical-Mediated Processes. Ola Didrik Saugstad. . Part III. Clinical Implications. Chapter 10. Antepartum Hypoxemia and the Developing Fetus. Donald M. Peebles, Mark A. Hanson. Chapter 11. Intrapartum Hypoxic-Ischemic Brain Injury. Jenny A. Westgate, Laura Bennet, Alistair J. Gunn. Chapter 12. Clinical Management of the Asphyxiated Newborn. Malcolm Levene, Sunil K. Sinha. Chapter 13. Neuroimaging of Hypoxic-Ischemic Encephalopathy. Mary Rutherford. Chapter 14. Thermal Influence on the Asphyxiated Newborn. Marianne Thoresen. . Part IV Medico-Legal Aspects. Chapter 15. Medico-Legal Implications of Hypoxic-Ischemic Brain Injury. Steven M. Donn, Malcolm L. Chiswick, Paula Whittell, Susan Anderson.
£143.95
Springer-Verlag New York Inc. Eye Tracking
Book SynopsisThis volume explores the latest eye-tracking methodologies that help researchers understand the background, methods, and applications involved in these studies. The chapters in this book cover topics such as methods and models of eye-tracking in natural environments; natural gaze informatics (i.e., assisted wheelchair mobility); eye-tracking application to understand the visual control of locomotion; eye movement in neurological disorders; and eye movements in sports research and practice. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Eye Tracking: Background, Methods, and Applications is a valuable resource for experienced and novice researchers interested in learning more about this field and its future developments.Table of ContentsSeries Preface...Preface…Table of Contents…Contributing Authors…1. The Eyes as a Window to the Brain and MindLisa Graham, Julia Das, Jason Moore, Alan Godfrey, and Samuel Stuart2. A Brief History of Eye Movement ResearchAbbey Fletcher, Stephen Dunne, and Joe Butler3. Eye-Tracking Hardware: Past to Present, and BeyondPawel Kasprowski4. Methods and Models of Eye-Tracking in Natural EnvironmentsAlex J. Harston and Aldo A. Faisal5. Definition, Modeling, and Detection of Saccades in the Face of Post-Saccadic OscillationsRichard Schweitzer and Martin Rolfs6. Natural Gaze Informatics: Towards Intelligence Assisted Wheelchair MobilityMahendran Subramanian and Aldo A. Faisal7. Eye-Tracker Outcomes from Static, Mobile, Virtual Reality Eye-Tracking DevicesNicholas P. Murray, Brittany M. Trotter, Gustavo Sandri Heidner, Callie Herman, and Melissa Hunfalvay8. Translational Attentional Control Theory to Applied Psychological Eye Tracking ResearchWilliam R. Young and Toby J. Ellmers9. Eye-Tracking Application to Understand the Visual Control of LocomotionEllen Lirani-Silva and Rodrigo Vitorio10. Eye Movement in User Experience and Human-Computer Interaction ResearchLinden J. Ball and Beth H. Richardson11. Eye Movement in Neurological DisordersJulia Das, Lisa Graham, Rosie Morris, Gill Barry, Alan Godfrey, Richard Walker, and Samuel Stuart12. Eye Movements in Sports Research and Practice: Immersive Technologies as Optimal Environments for the Study of Gaze BehaviorDavid J. Harris, Mark R. Wilson, Tim Holmes, Toby de Burgh, and Samuel J. VineSubject Index List…
£161.99
John Wiley & Sons Inc Neuropsychopharmacology and Therapeutics
Book SynopsisNeuropsychopharmacology is a relatively new subject area in the neurosciences.Table of ContentsPreface xiii About the Companion Website xv 1 Introduction to Neuropsychopharmacology 1 1.1 Overview 1 1.2 A Brief Overview of the Anatomy and Function of the Brain 2 1.2.1 The Brainstem 2 1.2.2 The Metencephalon 3 1.2.3 Diencephalon 4 1.2.4 The Telencephalon 5 1.2.5 The Cerebral Ventricles and Cerebrospinal Fluid 7 1.3 Important Neurotransmitters 7 1.3.1 GABA and GABA Receptors 7 1.3.2 Glutamate and Glutamate Receptors 10 1.4 Central Nervous System Stimulant and Depressant Drugs 11 1.5 Central Nervous System (CNS) Stimulant Drugs 13 1.5.1 Psychomotor Stimulants 13 1.5.2 Analeptic Drugs 19 1.6 Depressant Drugs 21 1.6.1 Benzodiazepines 21 1.6.2 Other Depressant Drugs 23 1.7 Genetics 23 1.8 Electroencephalography and Imaging Techniques 24 1.8.1 Electroencephalography 24 1.8.2 X-Rays 24 1.8.3 Computed Tomography 24 1.8.4 Positron Emission Tomography 25 1.8.5 Magnetic Resonance Imaging 25 1.8.6 Functional MRI 25 1.9 Diagnostic Criteria for Mental Disorders 25 1.10 Animals Models for CNS Disorders 26 1.11 Summary 27 2 Parkinson’s Disease 28 2.1 Overview 28 2.2 Historical Background 28 2.3 Epidemiology 29 2.4 Primary Clinical Features 29 2.5 Secondary Clinical Features 30 2.6 Parkinson’s Disease and the Extrapyramidal System 31 2.7 Neurotransmission in the Extrapyramidal System and Parkinson’s Disease 33 2.7.1 Modulation of the Direct and Indirect Pathways 35 2.8 Causes of Parkinson’s Disease 36 2.8.1 Genes and Parkinson’s Disease 37 2.8.2 Environmental Neurotoxins 39 2.8.3 Oxidative Stress 41 2.9 Summary 42 2.10 Pharmacotherapy for Parkinson’s Disease 42 2.10.1 L-DOPA (L-Dihydroxyphenylalanine) 43 2.10.2 L-DOPA Treatment 44 2.10.3 Adverse Effects of L-DOPA 44 2.10.4 Adverse Effects after Long-Term Treatment 46 2.10.5 Alternative Formulations of L-DOPA and Other Pharmacological Agents 48 2.11 Nonmotor Symptoms of Parkinson’ Disease and the Development of a New Hypothesis 53 2.12 Pharmacological and Nonpharmacological Strategies for Treatment of Other Motor and Nonmotor Symptoms of Parkinson’s Disease 55 2.13 Other Nonpharmacological Methods of Treating Parkinson’s Disease 56 2.13.1 Lesions of the Globus Pallidus or Subthalamic Nucleus 56 2.13.2 Neurostimulation 57 2.13.3 Brain Grafts 57 2.14 Possible Future Strategies to Treat Parkinson’s Disease 58 2.14.1 Stem Cell Therapy 58 2.14.2 Gene Therapy 58 2.15 Early Diagnosis for Treatment of Parkinson’s Disease 59 2.16 Summary and Conclusions 59 3 Memory, Dementia and Alzheimer’s Disease 61 3.1 Overview 61 3.2 Learning and Memory 61 3.2.1 Temporal Stages of Learning, Memory and Recall 62 3.2.2 Where are STM and LTM Stored in the Brain? 67 3.3 Overview of Dementia 69 3.4 Alzheimer’s Disease (AD) 71 3.4.1 Clinical Symptoms of Alzheimer’s Disease 72 3.4.2 Neuropathological Changes 74 3.4.3 Molecular Pathology 74 3.4.4 Staging of Alzheimer’s Disease 80 3.4.5 Onset of Alzheimer’s Disease 80 3.4.6 Neurochemical Changes in Alzheimer’s Disease 82 3.4.7 Pharmacotherapy of Alzheimer’s Disease 85 3.4.8 Future Pharmacological Strategies in the Treatment of Alzheimer’s Disease 88 3.4.9 Cardiovascular Disease 91 3.4.10 Conclusions 91 3.5 Summary 92 4 Epilepsy 93 4.1 Overview 93 4.2 Background 94 4.3 Classification and Types of Epilepsy 94 4.3.1 Focal Seizures 94 4.3.2 Generalized Seizures 95 4.3.3 Epilepsy Syndromes 97 4.3.4 Epidemiology 98 4.4 Underlying Causes of Epilepsy 98 4.5 Epileptic Mechanisms 99 4.5.1 Electrophysiological Mechanisms 99 4.5.2 Mechanisms Underpinning Drug Treatment of Epilepsy 100 4.6 Pharmacotherapy 101 4.6.1 Valproate (Valproic Acid and Sodium Valproate) 101 4.6.2 Phenytoin 105 4.6.3 Carbamazepine 106 4.6.4 Ethosuximide 107 4.6.5 Gabapentin 107 4.6.6 Pregabalin 108 4.6.7 Lamotrigine 109 4.6.8 Tiagabine 109 4.6.9 Topiramate 110 4.6.10 Levetiracetam 110 4.6.11 Retigabine 111 4.6.12 Zonisamide 111 4.6.13 Benzodiazepines 112 4.6.14 Barbiturates 112 4.7 Vagal Nerve Stimulation 113 4.8 Summary 113 5 Attention Deficit Hyperactivity Disorder 115 5.1 Overview 115 5.2 Background to ADHD 116 5.3 Diagnostic Criteria for ADHD 118 5.4 ADHD and Comorbidity 119 5.5 Epidemiology 120 5.6 Aetiology of ADHD 120 5.6.1 Genetic Factors 120 5.6.2 Environmental Factors 121 5.7 The Pathophysiology of ADHD 122 5.7.1 The Prefrontal Cortex, Executive Function and ADHD 122 5.7.2 Frontocortical-Striatal Networks and ADHD 126 5.8 The Biochemical Hypothesis of ADHD 130 5.9 Executive Functional Skills, Neurodevelopment and ADHD 132 5.10 Summary of the Pathophysiology of ADHD 135 5.11 Management of ADHD 135 5.11.1 Pharmacotherapy 136 5.11.2 Nonpharmacological Management of ADHD 142 5.12 Summary and Conclusions 144 6 Affective Disorders 1: Depression 147 6.1 Outline 147 6.2 Emotion, Mood and Affective Disorders 148 6.3 Background to Depression 149 6.4 Clinical Features of Major Depressive Disorder 150 6.4.1 Subtypes of Depressive Disorders 150 6.5 Epidemiology 152 6.6 Causes of Depression 153 6.6.1 Genetic Influences 153 6.6.2 Biochemical Hypotheses of Depression 154 6.7 Stress, Learned Helplessness and Depression 163 6.7.1 Stress and MDD 164 6.7.2 What is Stress? 164 6.7.3 Stress and Depression 166 6.7.4 Brain Derived Neurotropic Factor, Neurotropic Effects and Depression 167 6.7.5 Genetics, Stress and Depression 168 6.7.6 Early-Life Stress, Depression and Epigenetics 169 6.7.7 Depression and Inflammation 171 6.7.8 Depression and Glutamate 171 6.7.9 Depression and Physical Diseases 171 6.8 Drug Treatment of Depression 172 6.8.1 Overview 172 6.8.2 Types of Antidepressant Drug 174 6.8.3 Possible Future Drugs for MDD 186 6.9 Nonpharmacological Treatments for Depression 187 6.9.1 Electroconvulsive Therapy 187 6.9.2 Transcranial Magnetic Stimulation 188 6.9.3 Vagus Nerve Stimulation 189 6.9.4 Phototherapy (Light Therapy) 189 6.9.5 Deep Brain Stimulation 190 6.9.6 Cognitive Behavioural Therapy 190 6.9.7 Interpersonal Therapy 191 6.9.8 Behavioural Therapy 192 6.9.9 Mindfulness-Based Cognitive Therapy 192 6.10 Summary 192 7 Affective Disorders 2: Bipolar Disorder 194 7.1 Outline 195 7.2 Background to Bipolar Disorder 195 7.3 Clinical Features of Bipolar Disorder and Diagnostic Criteria 196 7.3.1 Symptoms of Mania 196 7.3.2 Symptoms of Hypomania 197 7.3.3 Symptoms of Depression 197 7.3.4 Categories of Bipolar Disorder 197 7.3.5 Rapid Cycling 197 7.3.6 Mixed Features 197 7.3.7 Cyclothymia 198 7.3.8 Suicide 198 7.3.9 Course of Illness 198 7.4 Epidemiology 198 7.5 Cause of Bipolar Disorder 199 7.5.1 Genetic Factors 199 7.5.2 Environmental Factors 199 7.5.3 Neurobiology of Bipolar Disorder 199 7.6 Management of Bipolar Disorder 201 7.6.1 Pharmacotherapy 201 7.6.2 Drugs Used in the Treatment of Bipolar Disorder 204 7.7 Pregnancy and Bipolar Disorder 208 7.8 Psychological Treatments 208 7.8.1 Psychoeducation 208 7.8.2 Family-Focused Treatment 209 7.8.3 Cognitive Behavioural Therapy 209 7.8.4 Interpersonal and Social Rhythm Therapy 209 7.8.5 Lifestyle Changes 210 7.9 Summary and Conclusions 210 8 Anxiety Disorders 211 8.1 Overview 211 8.2 Background 212 8.3 Anxiety Disorders and Diagnostic Criteria 212 8.3.1 Generalized Anxiety Disorder 212 8.3.2 Social Anxiety Disorder 213 8.3.3 Panic Attack and Panic Disorder 214 8.3.4 Agoraphobia 215 8.3.5 Others Types of Anxiety Disorders 216 8.4 Neurobiology of Anxiety Disorders 216 8.4.1 Fear and the Amygdala 216 8.4.2 Anatomy and Circuitry of the Amygdala 217 8.4.3 Physiological Responses to Fear-Eliciting Stimuli 217 8.4.4 Conditioned Fear Response 220 8.4.5 Conditioned Fear Extinction 223 8.5 Worry 224 8.6 Are there Other Anxiety Circuits? 225 8.7 Neurotransmitters and Anxiety Disorders 225 8.8 Management of Anxiety Disorders 226 8.8.1 Pharmacotherapy 226 8.8.2 Psychosocial Therapies 232 8.9 Summary and Outcomes 234 9 Sleep and Sleep Disorders 236 9.1 Overview 236 9.2 Introduction 237 9.3 Physiology of Sleep 238 9.3.1 Stages of Sleep 238 9.3.2 The Ascending Reticular Activating System 240 9.3.3 Slow Wave Sleep Mechanisms 242 9.3.4 Rapid Eye Movement Sleep Mechanisms 245 9.4 Sleep Disorders 246 9.4.1 Insomnia 246 9.4.2 Hypersomnia or Hypersomnolence 254 9.5 Summary and Conclusions 257 10 Schizophrenia 259 10.1 Overview 259 10.2 Background 260 10.3 Clinical Features of Schizophrenia 264 10.3.1 Phases of Schizophrenia 264 10.3.2 Diagnostic Criteria for Schizophrenia 265 10.3.3 Violence, Self-Harm and Suicide 265 10.3.4 General Physical Health and Mortality 266 10.4 Epidemiology 266 10.5 Pathology 266 10.6 Aetiology 267 10.6.1 Genetics of Schizophrenia 267 10.6.2 Environmental Risk Factors 268 10.7 Developmental Hypothesis of Schizophrenia 270 10.8 Biochemical Hypotheses 270 10.8.1 Dopamine and the Dopamine Hypothesis of Schizophrenia 270 10.8.2 The Mesolimbic System and Schizophrenia 273 10.8.3 The Mesocortical System and Schizophrenia 273 10.8.4 Glutamate, GABA and Dopamine: A Revised Hypothesis of Schizophrenia 274 10.9 Management of Schizophrenia 277 10.9.1 Pharmacotherapy 277 10.9.2 Nonpharmacological Management of Schizophrenia 288 10.10 Summary and Conclusions 288 11 Drug Abuse and Addiction 290 11.1 Outline 290 11.2 Background 291 11.3 Neurobiology of Substance Abuse and Addiction 293 11.3.1 The Mesolimbic Reward Systems and Addictive Drugs 293 11.3.2 Extensions of the Hypothesis 298 11.3.3 Transition from Hedonic Actions to Habits to Compulsions 300 11.3.4 Summary 301 11.4 Risk Factors 301 11.4.1 Environmental Factors 301 11.4.2 Genetic Factors 302 11.5 Management of Addiction 302 11.5.1 Alcohol 306 11.5.2 Heroin 307 11.6 Summary 308 References 310 Index 327
£47.45
John Wiley & Sons Inc An Introduction to Pain and Its Relation to
Book SynopsisIntroduction to Pain and its relation to Nervous System Disorders provides an accessible overview of the latest developments in the science underpinning pain research, including, but not limited to, the physiological, pathological and psychological aspects.Table of ContentsList of contributors ix Foreword xiii Acknowledgements xv Notes on authors xvii Introduction 1Anna A. Battaglia Section I: Neurobiology of pain: Recent advances 11 1 Anatomy of pain pathways 13Andrew J. Todd 2 Spinal plasticity of the nociceptive system: The role of central sensitisation in chronic pain states 35Alban Latrémolière 3 Symptoms and pathology in neuropathic pain 89Matthew Thakur and Stephen B. McMahon 4 Recent advances in neuroimmune interactions in neuropathic pain: The role of microglia 123Elizabeth A. Old, Louise S. C. Nicol and Marzia Malcangio 5 Genetics and epigenetics of pain 149Franziska Denk and Stephen B. McMahon 6 The cannabinoid system and its role in nociception 169Massimiliano Beltramo 7 EphB receptors and persistent pain 201Isabella Gavazzi Section II: Pain in the brain 225 8 Brain imaging in experimental pain 227Massieh Moayedi and Tim V. Salomons 9 Placebo effects in pain 249Luana Colloca, Adam P. Horin and Damien Finniss 10 Psychology and pain 267Lance M. McCracken Section III: Pain in the lifecycle and in nervous system disorders 281 11 Pain in neonates and infants 283Fiona Moultrie, Segzi Goksan, Ravi Poorun and Rebeccah Slater 12 How do people with autism spectrum disorders (ASD) experience pain? 295Cecile Rattaz, Amandine Dubois and Amaria Baghdadli 13 Pain and depression: The janus factor of human suffering 317Angela Iannitelli and Paola Tirassa 14 Pain in multiple sclerosis: From classification to treatment 345Claudio Solaro and Michele Messmer Uccelli 15 Pain perception in dementia 361Miriam Kunz and Stefan Lautenbacher 16 The role of cognitive impairment in the placebo and nocebo effects 373Martina Amanzio 17 An overview of pain in Parkinson’s disease 387Panagiotis Zis, Elisaveta Sokolov and Kallol Ray Chaudhuri Appendix: Interviews with chronic pain patients 409 Index 413
£51.25
John Wiley & Sons Inc Brain2brain
Book SynopsisOvercome resistance and fully engage clients by bringing neuroscience into treatment Brain2Brain: Enacting Client Change Through the Persuasive Power of Neuroscienceapplies the popular topic of neuroscience in mental health to everyday practice, showing therapists how to teach their clients brain-based strategies for making changes and improving their lives. Cutting-edge findings in neuroscience are translated into language that clients will understand, and sidebars provide therapists more detailed information relating to particular disorders. With a holistic approach that incorporates mental, spiritual, and physical skills, knowledge, and exercises, this book provides a clear, complete resource for incorporating neuroscience into therapy. Case examples illustrate how the material can be used with different types of clients and situations, and sample dialogues and client handouts help therapists easily incorporate these techniques into their practice. Many clieTable of ContentsPreface vii Acknowledgments xix About the Author xxi 1 Applying Neuroscience 1 Teaching Practical Neuroscience 2 2 Promoting Brain Health 33 First S of Planting SEEDS 33 First E of SEEDS 36 Education 39 d of SEEdS 40 Second S of Planting SEEDS 50 3 Developing Memory Systems 63 Memory Systems 63 4 Autostress Disorders 91 Top Down and Bottom Up 91 5 When Anxiety Is Generalized 113 Balancing the Autonomic Nervous System 114 6 Focalized Anxiety 129 Facing Fear and Avoidance 129 Phobias 141 Panic Disorder 143 7 Posttraumatic Stress Disorder 149 Phase 1: Stabilization 150 Phase 2: Memory Integration 157 Phase 3: Posttraumatic Growth 177 8 Obsessive-Compulsive Disorder 183 Describing the OCD Circuit 185 Order 192 Health Obsessions 198 9 Depression 201 Gender and Depression 201 Role of Inflammation 202 Anxiety with Depression 205 Shifting to Action 211 Social Lift 216 Default Mode and Rumination 218 Orchestrating a Broad Approach 220 References 225 Author Index 247 Subject Index 255
£24.76
John Wiley and Sons Ltd Neurobionics The Biomedical Engineering of
Book SynopsisTechnological advances have greatly increased the potential for, and practicability of, using medical neurotechnologies to revolutionize how a wide array of neurological and nervous system diseases and dysfunctions are treated.Table of Contents1. The Historical Foundation of Bionics Nick Donaldson and Giles.S. Brindley 1.1 Bionics Past & Future 1.2 History in 1973 1.2.1 Biomaterials 1.2.2 Nerve Stimulation & Recording 1.2.3 Transistors 1.2.4 Conclusion 1.3 Anaesthesia 1.4 Aseptic Surgery 1.5 Clinical Observation & Experiments 1.6 Hermetic Packages 1.6.1 Vacuum Methods 1.6.2 Welding 1.6.3 Glass 1.6.4 Glass Ceramics & Solder Glasses 1.6.5 Ceramics 1.6.6 Microcircuit Technologies 1.6.7 Leak Testing 1.7 Encapsulation (Electrical Insulation) 1.7.1 Insulation 1.7.2 Under-water insulation 1.7.3 Silicones 1.7.4 Primers 1.8 Early Implanted Devices 1.9 Afterword References 2. Development of Stable Long-Term Electrode Tissue Interfaces for Recording and Stimulation Jens Schouenborg 2.1 Introduction 2.2 Tissue responses in the brain to an implanted foreign body 2.2.1 Acute tissue responses 2.2.2 Chronic tissue responses 2.2.3 On the importance of physiological conditions 2.3 Brain Computer Interfaces (BCI) - state of the art 2.4 Biocompatibility of BCI – on the importance of mechanical compliance 2.5 Novel electrode constructs and implantation procedures 2.5.1 Methods to implant ultraflexible electrodes 2.5.2 Surface configurations 2.5.3 Matrix embedded electrodes 2.5.4 Electrode arrays encorporating drugs 2.6 Concluding remarks Acknowledgements References 3. Electrochemical Principles of Safe Charge Injection Stuart F. Cogan, David J. Garrett and Rylie A. Green 3.1 Introduction 3.2 Charge Injection Requirements 3.2.1 Stimulation Levels for Functional Responses 3.2.2 Tissue damage thresholds 3.2.3 Charge Injection Processes 3.2.4 Capacitive Charge Injection 3.2.5 Faradaic Charge Injection 3.2.6 Stimulation Waveforms 3.2.7 Voltage Transient Analysis 3.3 Electrode Materials 3.3.1 Non-noble Metal Electrodes 3.3.2 Noble metals 3.3.3 High Surface Area Capacitor Electrodes 3.3.4 Three-dimensional Noble Metal Oxide Films 3.4 Factors Influencing Electrode Reversibility 3.4.1 In vivo versus saline charge injection limits 3.4.2 Degradation Mechanisms and Irreversible Reactions 3.5 Emerging Electrode Materials 3.5.1 Intrinsically conductive polymers 3.5.2 Carbon Nanotubes and Conductive Diamond 3.6 Conclusion References 4. Principles of Recording from an Electrical Stimulation of Neural Tissue James B. Fallon and Paul M. Carter 4.1 Introduction 4.2 Anatomy and physiology of neural tissue 4.2.1 Active Neurons 4.3 Physiological principles of recording from neural tissue 4.3.1 Theory of recording 4.3.2 Recording electrodes 4.3.3 Amplification 4.3.4 Imaging 4.4 Principles of Stimulation of Neural Tissue 4.4.1 Introduction 4.4.2 Principles of Neural Stimulator Design 4.4.3 Modelling Nerve Stimulation 4.4.4 The Activating Function 4.4.5 Properties of Nerves Under Electrical Stimulation 4.5 Safety of Electrical Stimulation 4.5.1 Safe Stimulation Limits 4.5.2 Metabolic Stress 4.5.3 Electrochemical Stress 4.6 Conclusion References 5. Wireless Neurotechnology for Neural Prostheses Arto Nurmikko, David Borton and Ming Yin 5.1 Introduction 5.2 Rationale and overview of Technical Challenges Associated with Wireless Neuroelectronic Interfaces 5.3 Wireless Brain Interfaces Require Specialized Microelectronics 5.3.1 Lessons learned from Cabled Neural Interfaces 5.3.2 Special Demands for Compact Wireless Neural Interfaces 5.4 Illustrative Microsystems for High Data Rate Wireless Brain Interfaces in Primates 5.5 Power Supply and Management for Wireless Neural Interfaces 5.6 Packaging and Challenges in Hermetic Sealing 5.7 Deployment of High Data Rate Wireless Recording in Freely Moving Large Animals 5.8 Summary and Prospects for High Data Rate Brain Interfaces for Neural Prostheses Acknowledgements References 6. Preclinical Testing of Neural Prostheses Douglas McCreery 6.1 Introduction 6.2 Biocompatibility testing of neural implants 6.3 Testing for mechanical and electrical integrity 6.4 In vitro accelerated testing and accelerated aging of neural implants 6.5 In vivo testing of neural prostheses 6.6 Conclusion References 7. Auditory and Visual Neural Prostheses Robert K. Shepherd, Peter M. Seligman, Mohit N. Shivdasani 7.1 Introduction 7.2 Auditory prostheses 7.2.1 The Auditory system 7.2.2 Hearing loss 7.2.3 Cochlear implants 7.2.4 Central auditory prostheses 7.2.5 Combined electric and acoustic stimulation 7.2.6 Bilateral cochlear implants 7.2.7 Future directions 7.3 Visual prostheses 7.3.1 The Visual system 7.3.2 Vision loss 7.3.3 Retinal prostheses 7.3.4 Central visual prostheses 7.3.5 Perception through a vision prosthesis 7.3.6 Future directions 7.4 Sensory prostheses and brain plasticity 7.5 Conclusions Acknowledgments References 8. Neurobionics: Treatments for Disorders of the Central Nervous System Hugh McDermott 8.1 Introduction 8.2 Psychiatric conditions 8.2.1 Obsessive-compulsive disorder 8.2.2 Major depression 8.3 Movement disorders 8.3.1 Essential Tremor 8.3.2 Parkinson’s disease 8.3.3 Dystonia 8.3.4 Tourette syndrome 8.4 Epilepsy 8.5 Pain 8.6 Future directions Acknowledgements References 9. Brain Computer Interfaces David M. Brandman and Leigh R. Hochberg 9.1 Introduction 9.2 Motor Physiology 9.2.1 Neurons are the fundamental unit of the Brain 9.2.2 Movement occurs through coordinated activity between multiple regions of the nervous system 9.2.3 Motor Cortex: a first source for iBCI signals 9.2.4 The Parietal Cortex is implicated in spatial coordination 9.2.5 The premotor and supplementary motor cortices are engaged in movement goals 9.2.6 Functional brain organization is constantly changing 9.2.7 Section Summary 9.3 The Clinical Population for Brain Machine Interfaces 9.3.1 Paralysis may result from damage to the motor system 9.3.2 Individuals with spinal cord injuries develop motor impairments that may impact hand function 9.3.3 Individuals with LIS develop motor impairment that impacts communication 9.4 BCI Modalities 9.4.1 BCI Modalities 9.4.2 Electrodes placed in the cortex record action potentials from neurons 9.4.3 Raw voltage signals are processed into spikes 9.5 BCI Decoding and applications 9.5.1 BCI decoders convert neural information into control of devices 9.5.2 BCI decoders allow for the control of prosthetic devices 9.6 Future directions 9.6.1 Scientific and engineering directions for developing BMI technology 9.6.2 Clinical directions for development of BCI technology 9.7 Conclusion References 10. Taking a Device to Market: Regulatory and Commercial Issues John L. Parker 10.1 Introduction 10.2 Basic Research 10.3 Preclinical Development 10.4 Clinical trials and approval to sell 10.5 Building a Business not a product 10.6 Conclusions References 11. Ethical Considerations in the Development of Neural Prostheses Frank J. Lane, Kristian P. Nitsch, and Marcia Scherer 11.1 Introduction 11.2 Individuals with Disabilities & Technology Development 11.3 Ethical Principles of Biomedical Research 11.4 Conclusions References Appendix: Companies Developing and/or Marketing Bionic Devices
£112.46
John Wiley and Sons Ltd Diet and Exercise in Cognitive Function and
Book SynopsisDiet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world's population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cogniTable of ContentsContributors xi Foreword Kirk I. Erickson xv Foreword Shin Murakami xvii Preface xixTahira Farooqui and Akhlaq A. Farooqui Acknowledgments xxi 1 Nutrition, Genes, and Neuroscience: Implications for Development, Health, and Disease 1Margaret Joy Dauncey 2 Neurochemical Effects of Western Diet Consumption on Human Brain 15Akhlaq A. Farooqui and Tahira Farooqui 3 Effect of Mediterranean Diet on Human Health in Seniors: Relationship with Telomers 29Virginia Boccardi and Giuseppe Paolisso 4 Effect of a Mediterranean Diet on Mental and Physical Quality of Life 39Marialaura Bonaccio, Giovanni de Gaetano, and Licia Iacoviello 5 Ketogenic Diets for the Treatment of Neurologic Disease 47Christa W. Habela and Eric H. Kossoff 6 Levels of n‐3 Fatty Acids and their Metabolites in the Brain: Their Impact on Brain Function and Neurological Disorders 59Akhlaq A. Farooqui and Tahira Farooqui 7 Homocysteine Levels in Neurological Disorders 73Ahmed A. Moustafa, Doaa H. Hewedi, Abeer M. Eissa, Dorota Frydecka, and Błażej Misiak 8 Table Salt and Dementia 83Surender R. Neravetla and Shantanu R. Neravetla 9 Contribution of Diet and Exercise in the Pathogenesis of Major Depression 93Adrian L. Lopresti 10 Role of Diet and Exercise in Diabetic Retinopathy 105Mohammad Shamsul Ola, Haseeb A. Khan, and Abdullah S. Alhomida 11 The Effect of Western Diet on Cognition in Humans 111Heather M. Francis and Richard J. Stevenson 12 Role of Diet and Exercise in Intervention of Age‐Induced Impairments 123Kanti Bhooshan Pandey and Syed Ibrahim Rizvi 13 Hormesis and Cognitive Function: An Evolutionary/Adaptive Arabesque Leading to Longevity 133Alistair V.W. Nunn, Geoffrey W. Guy, and Jimmy D. Bell 14 Polyphenols and Cognitive Function 143Edwin D. Lephart 15 Prevention of Dementia Through Modifiable Risk Factors 163Patsri Srisuwan 16 Physical Exercise Improves Cognition in Brain Disorders: Alzheimer’s Disease 175Trevor Archer and Danilo Garcia 17 Molecular, Biochemical, and Physiological Basis of Beneficial Actions of Exercise 183Undurti N. Das 18 Beneficial Effects of Exercise and Cognitive Training on Cognitive Functions in Older Adults: Introduction of Smart Aging Studies 205Rui Nouchi and Ryuta Kawashima 19 Exercise and Cognitive Functions 213Bijli Nanda and S. Manjunatha 20 Role of Sleep in Cognition, Immunity, and Disease and Its Interaction with Exercise 225Mark R. Zielinski and Dmitry Gerashchenko 21 Effect of Forced and Voluntary Exercise on Neural Plasticity Mediated by Astrocytes 241Caren Bernardi, Mario Roberto Generosi Brauner, and Carlos Alberto Goncalves 22 Effect of Exercise on the Aging Brain 253Bonita L. Marks 23 The Effects of Exercise on Neuronal Survival 267Michael J. Chen 24 Exercise and Cognitive Function in Older Adults 279Nicola J. Gates and Maria Fiatarone Singh 25 Research Issues and Clinical Implications of Exercise Effects in the Treatment of Depressive and Anxiety Disorders 295A. Garrett Hazelton, Richard Bloch, and Sy Saeed 26 Exercise‐Induced Protection Against Aging and Neurodegenerative Diseases: Role of Redox‐ and Mitochondrial‐Based Alterations 309Ines Marques‐Aleixo, Estela Santos‐Alves, Paula I. Moreira, Paulo J. Oliveira, Jose Magalhaes, and Antonio Ascensao 27 Exercise, Neuroplasticity, and Growth Factors in Adolescence 323Helios Pareja‐Galeano, Sara Mayero, and Fabian Sanchis‐Gomar 28 Summary, Perspective, and Direction for Future Studies 339Tahira Farooqui and Akhlaq A. Farooqui Index 349
£170.00
John Wiley and Sons Ltd Spectrums of Amyotrophic Lateral Sclerosis
Book SynopsisSPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the fieldIn Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies. In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed. Readers will also benefit from the inclusion of:A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development and clinical trial designExplorations of the genetic basis of ALS, prospective sALS etiologies, and the involvement of microbiome in ALSDiscussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cellsExaminations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategiesPerfect for clinical neurologists, healthcare providers and caretakers, clinicians, and researchers studying motor neuron disease, Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions is also an indispensable resource for the neurodegenerative research community, neurology residents, and graduate-level neuroscience students.Table of ContentsContributors xiii Preface xvii Acknowledgments xix Foreword xxi CHAPTER 1 Clinical Heterogeneity of ALS – Implications for Models and Therapeutic Development 1 Serena Lattante and Mario Sabatelli Introduction 1 Clinical Heterogeneity of ALS 2 Familial and Sporadic ALS 2 Age of Onset 3 Survival 3 Classic ALS, LMN Form, and UMN Form 4 Site of Onset 4 Diagnosis of ALS 5 ALS and Its Relationship with Frontotemporal Dementia and Myopathies 5 Pleiotropy of ALS Genes 6 Genetic Models to Study ALS 8 In Vivo Models 8 In Vitro Models 9 Conclusion 10 Conflict of Interest 11 Copyright and Permission Statement 11 References 11 CHAPTER 2 Genetic Basis of ALS 17 Jay P. Ross, Patrick A. Dion, and Guy A. Rouleau Introduction 17 Genes Causing ALS 18 Superoxide Dismutase 1 (SOD1) 18 TAR DNA‐Binding Protein 43 (TDP‐43) 19 Fused in Sarcoma (FUS) 19 Chromosome 9 Open Reading Frame 72 (C9orf72) 20 Recently Discovered Genes 21 Annexin A11 (ANXA11) 21 Glycosyltransferase 8 Domain Containing 1 (GLT8D1) 23 Stathmin‐2 (STMN2) 23 Aspects of ALS Heritability 24 Sporadic vs. Familial 24 Penetrance and the Oligogenic Hypothesis 24 Multistep Model 25 Noncoding Variation 25 Regulatory and Intronic Variants 25 Epigenetics 26 Conclusions 27 Acknowledgments 27 Conflict of Interest 27 Copyright and Permission Statement 28 References 28 CHAPTER 3 Susceptibility Genes and Epigenetics in Sporadic ALS 35 Jessica R. Morrice, Christopher A. Shaw, and Cheryl Y. Gregory‐Evans Introduction 35 Environmental Associations in sALS 36 Genetic Basis of sALS 38 Identification of sALS Susceptibility Genes 39 Candidate sALS Susceptibility Genes 40 Unc13a 40 Dpp6 40 C21orf2 41 Epigenetic Mechanisms in sALS 41 Methylation in sALS 41 miRNAs in sALS 42 Post‐Translational Histone Modification in sALS 43 Epigenetic Analysis in Monozygotic sALS Twins 44 Modifications to the Epigenome by Environmental Factors 44 In Utero Environmental Exposures 45 Environmental in Utero Epigenomic Alterations 45 Post Utero Exposures 45 Conclusion 46 Conflict of Interest 46 Copyright and Permission Statement 47 References 47 CHAPTER 4 The Lessons of ALS‐PDC – Environmental Factors in ALS Etiology 57 Christopher A. Shaw and Thomas E. Marler Introduction 57 Koch’s Postulates in the Search of Etiological ALS Factors 58 Neurological Disease Clusters 59 The Natural History of ALS‐PDC 60 Investigating Etiological Factors 62 Identified Cycad Toxicants 67 Aluminum and Ionic Etiologies for ALS‐PDC 69 Other Molecules That Might Have Been Involved in ALS‐PDC 70 A Putative Viral Etiology for ALS‐PDC on Guam and ALS in General 70 The Continuing Importance of ALS‐PDC 71 Summary and Conclusions 73 Acknowledgments 74 Conflict of Interest 74 Copyright and Permission Statement 74 References 75 CHAPTER 5 The Microbiome of ALS – Does It Start from the Gut? 81 Audrey Labarre and Alex Parker Introduction 81 Recent Studies 82 Animal and in vitro Studies 82 Clinical Studies 91 How Could the Microbiome Contribute to ALS? 92 Gut Barrier and Membrane Permeability 93 Inflammation and Immune Response 94 Neurotoxins 95 Energy Metabolism 96 Microbiome Modulation as a Potential Therapeutic Avenue 96 Conclusion 97 Conflict of Interest 97 Copyright and Permission Statement 97 References 98 Chapter 6 Protein Aggregation in Amyotrophic Lateral Sclerosis 105 Christen G. Chisholm, Justin J. Yerbury, and Luke McAlary Introduction 105 Pathological Protein Inclusions Associated with ALS 106 Protein Homeostasis and Misfolded Protein Partitioning in ALS 107 Consequences of Protein Aggregation in ALS 108 The Primary Aggregating Proteins in ALS 110 Superoxide Dismutase‐1 (SOD1) 110 Transactivated Response DNA Binding Protein 43 (TDP‐43) 111 Fused in Sarcoma (FUS) 111 Prion‐like Propagation of Protein Aggregation in ALS 112 Conclusion 113 Acknowledgments 114 Conflict of Interest 114 Copyright and Permission Statement 114 References 114 CHAPTER 7 Evidence for a Growing Involvement of Glia in Amyotrophic Lateral Sclerosis 123 Rowan A. W. Radford, Andres Vidal‐Itriago, Natalie M. Scherer, Albert Lee, Manuel Graeber, Roger S. Chung, and Marco Morsch Introduction 123 Non‐neuronal Cells Play Important Roles in Neurodegeneration Including in ALS 123 Glial Cells and Their Established Functions 123 Neurodegeneration and the Role of Glial Cells 124 Glia in ALS 124 Glial Dysfunction Is a Common Hallmark of ALS Patients 125 Glial Activation in ALS Models 126 Major Pathological Forms of ALS 126 Microglia‐Related ALS Pathology 126 Microglia in SOD1‐ALS Pathology 126 Microglia in TDP‐43‐ALS Pathology 127 Microglia in FUS‐ALS Pathology 128 Astrocyte‐Related ALS Pathology 128 Oligodendrocyte‐Related ALS Pathology and Glial Inclusion Formation 129 Glial Inclusion Formation in ALS 130 Oligodendrocytes 130 Astrocytes 131 The Role of Glial Cells in SOD1 Pathology Might Be Different from Other Forms of ALS 131 Conclusion 132 Acknowledgments 134 Conflict of Interest 134 Copyright and Permission Statement 134 References 134 CHAPTER 8 Animal Models of ALS – Current and Future Perspectives 143 Robert A. Déziel, Amber L. Marriott, Denis G. Kay, and Daphne A. Gill Introduction 143 The Clinical Manifestations of ALS 143 Limb Onset 144 Bulbar Onset 144 Respiratory Onset 144 Current and Experimental Pharmacological Interventions 145 Riluzole 145 Edaravone 146 Future Directions for Pharmacological Interventions 146 Causative Factors in the Development of ALS 146 Genetic Factors 146 Environmental and Epigenetic Factors 148 Gut and Microbial Factors 148 Animal Models of ALS 150 One‐hit Models of ALS 150 Multi‐hit Models of ALS 151 Future Model Development 153 Acknowledgments 153 Conflict of Interest 154 Copyright and Permission Statement 154 References 154 CHAPTER 9 Clinical Trials in ALS – Current Challenges and Strategies for Future Directions 161 Kristiana Salmon and Angela Genge 161 Introduction 161 Challenges in ALS Clinical Trials 162 Disease Heterogeneity 162 Lack of Established Biomarkers 163 Limitations of Conventional Outcome Measures 163 ALSFRS‐R 163 FVC/SVC 164 HHD 164 Survival vs. Function 164 Phase II Trial “Paradox” 165 Patient Recruitment and Retention 166 Assumptions for Lead‐In Phases 166 Navigating Regulatory Nuances 167 Future Directions 167 Advances in Disease Understanding and Assessment 168 Disease Heterogeneity 168 Emerging Biomarkers 168 Novel Outcome Measures 169 New Approaches to Trial Design 170 Cautious Phase II Design 170 Adaptive Trial Design 171 Platform Trials 172 Bayesian Statistics 172 Education 173 People Make or Break a Trial 173 Conclusion 174 Acknowledgments 175 Conflict of Interest 175 Copyright and Permission Statement 175 References 175 CHAPTER 10 Future Priorities and Directions in ALS Research and Treatment 181 Jessica R. Morrice, Michael Kuo, and Christopher A. Shaw Introduction 181 Etiological Heterogeneity of ALS 182 ALS Risk Factors 183 Cellular Dysfunction in ALS 185 ALS as a “Treatable” Disease 186 The Importance of Effective Biomarkers 187 Future Therapeutic Avenues for a Heterogeneous Disease 188 Ongoing Clinical Trials Using CuATSM 188 Conclusions and the Road Forward in ALS Research and Treatment 190 Conflict of Interest 191 Copyright and Permission Statement 191 References 191 Index 000
£95.36
John Wiley and Sons Ltd Essential Neurology
Book SynopsisA brand new edition of Essential Neurology brings the text fully up-to-date. This book is a core text for medical students and junior doctors, who want a comprehensive yet concise practical guide to clinical neurology. To make the book more readable and digestible, we have introduced colour into the text. This text provides clear explanations of the most common neurological and neurosurgical disorders. The most up-to-date clinical methods are covered to ensure students are learning the newest techniques. To enhance the readers' understanding of this subject more illustrations, line drawings and scans are incorporated into the text. Another new addition is the inclusion of clinical cases with self-assessment questions at the end of every chapter. These help to clearly illustrate the clinical presentations of key neurological disorders. Essential Neurology is ideal for medical students on neurology attachments and an excellent review text for the MRCP examTrade ReviewReviews of previous editions: "This is an excellent introductory text for medical students who want their neurology without frills." (British Medical Journal) "A well-presented manual of practical clinical neurology recommended as easy and enjoyable fundamental reading." (Brain) "This is an excellent book with a very good all round approach to an understanding of neurology at student level" (Journal of Neurology, Neurosurgery and Psychiatry)Table of ContentsPreface to the fourth edition. Preface to the first edition. Acknowledgements. Abbreviations. 1 Clinical skills, physical signs and anatomy. 2 Stroke. 3 Brain tumour. 4 Head injury. 5 Parkinsonism, involuntary movements and ataxia. 6 Paraplegia. 7 Multiple sclerosis. 8 Cranial nerve disorders. 9 Nerve root, nerve plexus and peripheral nerve lesions. 10 Motor neurone disease, peripheral neuropathy, myasthenia gravis and muscle disease. 11 Unconsciousness. 12 Epilepsy. 13 Headache and facial pain. 14 Dementia. 15 Infections of the nervous system. Answers to case histories. Index.
£42.70
John Wiley and Sons Ltd Memory and the Computational Brain
Book SynopsisMemory and the Computational Brain offers a provocative argument that goes to the heart of neuroscience, proposing that the field can and should benefit from the recent advances of cognitive science and the development of information theory over the course of the last several decades. A provocative argument that impacts across the fields of linguistics, cognitive science, and neuroscience, suggesting new perspectives on learning mechanisms in the brain Proposes that the field of neuroscience can and should benefit from the recent advances of cognitive science and the development of information theory Suggests that the architecture of the brain is structured precisely for learning and for memory, and integrates the concept of an addressable read/write memory mechanism into the foundations of neuroscience Based on lectures in the prestigious Blackwell-Maryland Lectures in Language and Cognition, and now significantly reworked and expaTrade Review"The book covers wide-ranging ground--indeed, it passes for a computer science or philosophy textbook in places--but it does so in a consistently lucid and engaging fashion." (CHOICE, December 2009) "The authors provide a cogent set of ideas regarding a kind of brain functional architecture that could serve as a thought-provoking alternative to that envisioned by current dogma. If one is seriously concerned with understanding and investigating the brain and how it operates, taking the time to absorb the ideas conveyed in this book is likely to be time well spent." (PsycCRITIQUES, November 2009) "Along with a light complement of fascinating psychological case studies of representations of space and time, and a heavy set of polemical sideswipes at neuroscientists and their hapless computational fellow travelers, this book has the simple goal of persuading us of the importance of a particular information processing mechanism that it claims does not currently occupy center stage." (Nature Neuroscience, October 2009) Table of ContentsPreface. 1. Information. Shannon’s Theory of Communication. Measuring Information. Efficient Coding. Information and the Brain. Digital and Analog Signals. Appendix: The Information Content of Rare Versus Common Events and Signals. 2. Bayesian Updating. Bayes’ Theorem and Our Intuitions About Evidence. Using Bayes’ Rule. Summary. 3. Functions. Functions of One Argument. Composition and Decomposition of Functions. Functions of More than One Argument. The Limits to Functional Decomposition. Functions Can Map to Multi-Part Outputs. Mapping to Multiple-Element Outputs Does Not Increase Expressive Power. Defining Particular Functions. Summary: Physical/Neurobiological Implications of Facts about Functions. 4. Representations. Some Simple Examples. Notation. The Algebraic Representation of Geometry. 5. Symbols. Physical Properties of Good Symbols. Symbol Taxonomy. Summary. 6. Procedures. Algorithms. Procedures, Computation, and Symbols. Coding and Procedures. Two Senses of Knowing. A Geometric Example. 7. Computation. Formalizing Procedures. The Turing Machine. Turing Machine for the Successor Function. Turing Machines for ƒ is _even Turing Machines for ƒ+ Minimal Memory Structure. General Purpose Computer. Summary. 8. Architectures. One-Dimensional Look-Up Tables (If-Then Implementation). Adding State Memory: Finite-State Machines. Adding Register Memory. Summary. 9. Data Structures. Finding Information in Memory. An Illustrative Example. Procedures and the Coding of Data Structures. The Structure of the Read-Only Biological Memory. 10. Computing with Neurons. Transducers and Conductors. Synapses and the Logic Gates. The Slowness of It All. The Time-Scale Problem. Synaptic Plasticity. Recurrent Loops in Which Activity Reverberates. 11. The Nature of Learning. Learning As Rewiring. Synaptic Plasticity and the Associative Theory of Learning. Why Associations Are Not Symbols. Distributed Coding. Learning As the Extraction and Preservation of Useful Information. Updating an Estimate of One’s Location. 12. Learning Time and Space. Computational Accessibility. Learning the Time of Day. Learning Durations. Episodic Memory. 13. The Modularity of Learning. Example 1: Path Integration. Example 2: Learning the Solar Ephemeris. Example 3: “Associative” Learning. Summary. 14. Dead Reckoning in a Neural Network. Reverberating Circuits as Read/Write Memory Mechanisms. Implementing Combinatorial Operations by Table-Look-Up. The Full Model. The Ontogeny of the Connections? How Realistic is the Model? Lessons to be Drawn. Summary. 15. Neural Models of Interval Timing. Timing an Interval on First Encounter. Dworkin’s Paradox. Neurally Inspired Models. The Deeper Problems. 16. The Molecular Basis of Memory. The Need to Separate Theory of Memory from Theory of Learning. The Coding Question. A Cautionary Tale. Why Not Synaptic Conductance? A Molecular or Sub-Molecular Mechanism? Bringing the Data to the Computational Machinery. Is It Universal? References. Glossary. Index.
£86.36
John Wiley and Sons Ltd Memory and the Computational Brain
Book SynopsisMemory and the Computational Brain offers a provocative argument that goes to the heart of neuroscience, proposing that the field can and should benefit from the recent advances of cognitive science and the development of information theory over the course of the last several decades. A provocative argument that impacts across the fields of linguistics, cognitive science, and neuroscience, suggesting new perspectives on learning mechanisms in the brain Proposes that the field of neuroscience can and should benefit from the recent advances of cognitive science and the development of information theory Suggests that the architecture of the brain is structured precisely for learning and for memory, and integrates the concept of an addressable read/write memory mechanism into the foundations of neuroscience Based on lectures in the prestigious Blackwell-Maryland Lectures in Language and Cognition, and now significantly reworked and expaTrade Review"The book covers wide-ranging ground--indeed, it passes for a computer science or philosophy textbook in places--but it does so in a consistently lucid and engaging fashion." (CHOICE, December 2009) "The authors provide a cogent set of ideas regarding a kind of brain functional architecture that could serve as a thought-provoking alternative to that envisioned by current dogma. If one is seriously concerned with understanding and investigating the brain and how it operates, taking the time to absorb the ideas conveyed in this book is likely to be time well spent." (PsycCRITIQUES, November 2009) "Along with a light complement of fascinating psychological case studies of representations of space and time, and a heavy set of polemical sideswipes at neuroscientists and their hapless computational fellow travelers, this book has the simple goal of persuading us of the importance of a particular information processing mechanism that it claims does not currently occupy center stage." (Nature Neuroscience, October 2009) Table of ContentsPreface viii 1 Information 1 Shannon’s Theory of Communication 2 Measuring Information 7 Efficient Coding 16 Information and the Brain 20 Digital and Analog Signals 24 Appendix: The Information Content of Rare Versus Common 25 Events and Signals 2 Bayesian Updating 27 Bayes’ Theorem and Our Intuitions about Evidence 30 Using Bayes’ Rule 32 Summary 41 3 Functions 43 Functions of One Argument 43 Composition and Decomposition of Functions 46 Functions of More than One Argument 48 The Limits to Functional Decomposition 49 Functions Can Map to Multi-Part Outputs 49 Mapping to Multiple-Element Outputs Does Not Increase Expressive Power 50 Defining Particular Functions 51 Summary: Physical/Neurobiological Implications of Facts about Functions 53 4 Representations 55 Some Simple Examples 56 Notation 59 The Algebraic Representation of Geometry 64 5 Symbols 72 Physical Properties of Good Symbols 72 Symbol Taxonomy 79 Summary 82 6 Procedures 85 Algorithms 85 Procedures, Computation, and Symbols 87 Coding and Procedures 89 Two Senses of Knowing 100 A Geometric Example 101 7 Computation 104 Formalizing Procedures 105 The Turing Machine 107 Turing Machine for the Successor Function 110 Turing Machines for fis even 111 Turing Machines for f+ 115 Minimal Memory Structure 121 General Purpose Computer 122 Summary 124 8 Architectures 126 One-Dimensional Look-Up Tables (If-Then Implementation) 128 Adding State Memory: Finite-State Machines 131 Adding Register Memory 137 Summary 144 9 Data Structures 149 Finding Information in Memory 151 An Illustrative Example 160 Procedures and the Coding of Data Structures 165 The Structure of the Read-Only Biological Memory 167 10 Computing with Neurons 170 Transducers and Conductors 171 Synapses and the Logic Gates 172 The Slowness of It All 173 The Time-Scale Problem 174 Synaptic Plasticity 175 Recurrent Loops in Which Activity Reverberates 183 11 The Nature of Learning 187 Learning As Rewiring 187 Synaptic Plasticity and the Associative Theory of Learning 189 Why Associations Are Not Symbols 191 Distributed Coding 192 Learning As the Extraction and Preservation of Useful Information 196 Updating an Estimate of One’s Location 198 12 Learning Time and Space 207 Computational Accessibility 207 Learning the Time of Day 208 Learning Durations 211 Episodic Memory 213 13 The Modularity of Learning 218 Example 1: Path Integration 219 Example 2: Learning the Solar Ephemeris 220 Example 3: “Associative” Learning 226 Summary 241 14 Dead Reckoning in a Neural Network 242 Reverberating Circuits as Read/Write Memory Mechanisms 245 Implementing Combinatorial Operations by Table-Look-Up 250 The Full Model 251 The Ontogeny of the Connections? 252 How Realistic Is the Model? 254 Lessons to Be Drawn 258 Summary 265 15 Neural Models of Interval Timing 266 Timing an Interval on First Encounter 266 Dworkin’s Paradox 268 Neurally Inspired Models 269 The Deeper Problems 276 16 The Molecular Basis of Memory 278 The Need to Separate Theory of Memory from Theory of Learning 278 The Coding Question 279 A Cautionary Tale 281 Why Not Synaptic Conductance? 282 A Molecular or Sub-Molecular Mechanism? 283 Bringing the Data to the Computational Machinery 283 Is It Universal? 286 References 288 Glossary 299 Index 312
£39.85
John Wiley and Sons Ltd Drug Induced Movement Disorders
Book SynopsisThe understanding of drug-induced movement disorders is extremely difficult, and many physicians and clinicians find this a difficult and complex area to treat. The unique way in which the plethora of different drugs react and manifest with the patient's exact condition is particularly hard to manage and diagnose.Trade Review"This well written comprehensive book provides the reader with good clinical descriptions of the major movement disorders and with extensively referenced data on studies and trials regarding both drugs incriminated in abnormal movements and those useful in their management." "In conclusion, this comprehensive review of drug-induced movement disorders will be extremely useful to every clinician, particularly those interested in the fields of neurology and psychiatry." Christian Wider, European Neurology, December 5th 2005Table of ContentsSection 1: General Considerations. Chapter 1: Movement Disorders: Approach, Definitions and differential Diagnosis. Martin Cloutier, Anthony E. Lang. Chapter 2: Rating Scales for Movement Disorders. Wonodi I, Hong EH, Avila MT, Gunvant Thaker. Chapter 3: Spontaneous movement disorders in psychiatric patients. Irene Richard, Christopher O’Brien, Roger Kurlan. Section 2: Antipsychotics. Chapter 4: Pharmacology of typical and atypical agents. Gary Remington, Shitij Kapur. Chapter 5: Acute Drug-induced Dystonia. Michael F. Mazurek, Patricia I. Rosebush. Chapter 6: Drug-Induced Parkinsonism. Joseph H. Friedman, Martha E. Trieschmann, Hubert H. Fernandez. Chapter 7: Acute Akathisia. Author: Lenard A. Adler, John Rotrosen, Burt Angrist. Chapter 8: Neuroleptic Malignant Syndrome. Stewart A. Factor. Chapter 9: Classical Tardive Dyskinesia. Thomas M. Hyde, MD, Jose A. Apud, Whitney C. Fisher, Michael F. Egan. Chapter 10: Tardive dyskinesia Variants. Skidmore F, Weiner W, Burke R. Chapter 11: Movement Disorders caused by atypical antipsychotics. Karen E. Anderson. Chapter 12: Commentary: Is Tardive dyskinesia disappearing?James Lohr, MD. . . Section 3: Dopaminomimetic Drugs. Chapter 13: Dyskinesia induced by levodopa and dopamine agonists in Parkinson’s disease. John G. Nutt, Matthew Brodsky. Chapter 14: Stimulant Drugs. Anthony E. Munson, Juan Sanchez-Ramos, William J Weiner. Section 5: Other Drugs. Chapter 15: Antidepressants. Marie L. Moro-de-Casillas, David E. Riley. Chapter 16: Anticonvulsants. John C. Morgan, Madeline Harrison. Chapter 17: Miscellaneous Drugs. Daniel Tarsy
£147.56
John Wiley and Sons Ltd Child Neuropsychology
Book SynopsisBased on the most up-to-date research, Child Neuropsychology is a thorough and accessible guide to the key concepts and basic processes central to neuropsychological assessment and child evaluation.Trade Review"The editors and authors of this important volume have contributed thorough, integrative, and clearly articulated coverage of essential knowledge while placing an important emphasis on the dynamic change and course of development that distinguishes child/pediatric from adult neuropsychology... It is an engaging read that will be appreciated by graduate students as well as more senior practitioners across the neurosciences". (International Neuropsychological Society, October 2010)Table of Contents1 Introduction Jonathan Reed and Jody Warner Rogers Section 1 Key Concepts. 2 The Importance of Tracing Developmental Trajectories for Clinical Child Neuropsychology (Dagmara Annaz, Annette Karmiloff-Smith and Michael C. S. Thomas). 3 Child Brain Development (Hans J. ten Donkelaar). 4 Genetics of Learning Abilities and Disabilities: Implications for Cognitive Neuroscience and Translational Research (Yulia Kovas and Robert Plomin). 5 Brain Plasticity: Evidence from Children with Perinatal Brain Injury (Judy S. Reilly, Susan C. Levine, Ruth Nass and Joan Stiles). 6 Neuroimaging in Child and Adolescent Psychiatric Disorders (Paramala J Santosh and Ruksana Ahmed). 7 The Concept and Development of General Intellectual Ability (Mike Anderson). Section 2 Theory of Neuropsychological Development. 8 The Neuropsychology of Language Development (Frederic Dick, Robert Leech and Fiona Richardson). 9 The Neuropsychology of Visuo-spatial and Visuo-motor Development (Janette Atkinson and Marko Nardini). 10 The Neuropsychology of Children’s Memory (Arthur MacNeill Horton and Henry Soper). 11 The Neuropsychology of Attention Development (Maxine Sinclair and Eric Taylor). 12 Executive Functions and Development (Clare Hughes and Andrew Graham). 13 Self-regulation in the Developing Brain (Rebecca Todd and Marc Lewis). 14 Social Neuroscience (Simon Baron-Cohen and Bhismadev Chakrabarti). 15 Reading (Usha Goswami). 16 Developmental Dyscalculia (Brian Butterworth) Section 3 Practice. 17 Neuropsychological Assessment in a Neurological Setting (Ingram Wright and Peta Sharples) 18 Neuropsychological Assessment in Child Mental Health Contexts (Ian Frampton) 19 Applications of Neuropsychology in Schools (Sue Harrison and Jane Hood). 20 Neuropsychological Assessment in Medical Contexts Psychological Assessment in Medical Contexts (Sarah Helps). 21 A Clinician’s Guide to Child Neuropsychological Assessment and Formulation (Jody Warner Rogers and Jonathan Reed). Index.
£49.35
John Wiley and Sons Ltd Autism
Book SynopsisResearch on autism has flourished in recent years. As a result, specialism has developed and lines of research have become specialized and isolated. This collection of research on autism spectrum disorders investigates and cross-references a wide range of neurocognitive, clinical, and interventionist perspectives on autistic spectrum disorders research from functional Magnetic Resonance Imaging studies to naturalistic intervention. Accessible to students, parents and practitioners, Autism provides an overview of high profile research Features contributions from teams at the forefront of research output in the UK, Europe and the United States Introductory and concluding chapters highlighting major research themes while exploring broader issues on the integration of autism research, Trade Review“The book provides a highly captivating discussion of the varied set of approaches taken toward understanding persons with ASDs. The product is an engaging and highly readable effort that broadens and directs thinking about a complex developmental disorder and its manifestations.” (PsycCRITIQUES, March 2009) “Some essays do an outstanding job of reviewing past work, sharing current research, and suggesting new directions.” (Choice)Table of ContentsPreface. List of Contributors. 1. Introduction: Seeking Coherence in Autism: From fMRI to Intervention: Evelyn McGregor (University of St Andrews) , María Núñez (Glasgow Caledonian University), Katie Cebula (University of Edinburgh), and Juan Carlos Gómez (University of St Andrews). Part I: Neurocognitive Research. 2. New Insights From Neuroimaging Into the Emotional Brain in Autism: Bruno Wicker (Institut de Neurosciences Cognitives de la Méditerranée, Marseille). 3. Directedness, Egocentrism, and Autism: Justin H. G. Williams (University of Aberdeen Medical School). 4. Altered Salience in Autism: Developmental Insights, Consequences, and Questions: Warren Jones (Yale University) and Ami Klin (Yale University). 5. Abnormalities in “Cultural Knowledge” in Autism Spectrum Disorders: A Link Between Behavior and Cognition?: Eva Loth (Cambridge University). 6. Building the Whole Beyond Its Parts: A Critical Examination of Current Theories of Integration Ability in Autism: Beatriz López (University of the West of England). 7. The Influence of Conceptual Knowledge on Perceptual Processing in Autism: Danielle Ropar (University of Nottingham), Peter Mitchell (University of Nottingham), and Elizabeth Sheppard (University of Nottingham). 8. Executive Functioning in Autism Spectrum Disorder: Where It Fits in the Causal Model: Elisabeth L. Hill (Goldsmiths, University of London). Part II Clinical and Intervention Research. 9. How Young Children With Autism Treat Objects and People: Some Insights into Autism in Infancy From Research on Home Movies: Sandra Maestro (University of Pisa) and Filippo Muratori (University of Pisa). 10. Screening for Autism Spectrum Disorders in Primary School Aged Children: Joanna G. Williams (Cambridge University). 11. The Prosody–Language Relationship in Children With High-Functioning Autism: Joanne McCann (Queen Margaret University College, Edinburgh), Sue Peppé (Queen Margaret University College, Edinburgh), Fiona Gibbon (Queen Margaret University College, Edinburgh), Anne O’Hare (Royal Hospital for Sick Children, Edinburgh), and Marion Rutherford (Royal Hospital for Sick Children, Edinburgh). 12. Teaching Adults With Autism Spectrum Conditions to Recognize Emotions: Systematic Training for Empathizing Difficulties: Ofer Golan (Bar-Ilan University, Israel and Cambridge University) and Simon Baron-Cohen (Cambridge University). 13. Developing Social Interaction and Understanding in High-Functioning Individuals With Autism Spectrum Disorder: Aline-Wendy Dunlop (University of Strathclyde), Fiona Knott (University of Reading), and Tommy MacKay (University of Strathclyde). 14. Research Base for Intervention in Autism Spectrum Disorders: Glenys Jones (University of Birmingham) and Rita Jordan (University of Birmingham). 15. Stress in Parents of Children With Autism: Richard P. Hastings (University of Wales, Bangor). 16. Conclusion: Integrating Neurocognitive, Diagnostic, and Intervention Perspectives in Autism: Susan Leekam (University of Durham) and Evelyn McGregor (University of St Andrews). Index
£92.10
John Wiley and Sons Ltd Neuroscience Nursing
Book SynopsisSuperior An important resource for nurses Shanne McNamara, Vice President, British Association of Neuroscience Nurses Neuroscience Nursing is a comprehensive, practical text that reflects both the richness and the diversity of contemporary neuroscience nursing. It aims to inform the practice of neuroscience nursing through the report of current research, best available evidence, policy and education. This important new book is divided into several sections exploring anatomy and physiology of the nervous system; assessment, interpretation and management of specific problems in the neurological patient; neurological investigations and neurosurgical procedures; management of patients with intracranial disorders; and management of patients with long-term conditions. It also explores the underpinning concepts of neuroscience care, including its history and development, and legal and ethical issues. Uniquely, this text also includes patients' perspectives of lTrade Review“This book would be relevant to a wide ranging audience from students, to newly qualified, to those wishing to move into neuroscience and those who work within the field requiring a good resource book for updating their knowledge or as a reference.” (Nursing Times, 8 November 2012) "This high quality book would be an invaluable addition to a hospital unit or in a nurse's personal library." (Doody's, 14 October 2011) "They are well referenced and integrate theory with daily nursing care. . . This book is worth buying for personal use or as a reference in clinical settings." (Nursing Older People, 1 October 2011) "The clear, systematic organisation of this book will provide neuroscience nurses with detailed guidelines and rationales for care, but also will enable nurses caring for these patients to readily find specific information for the care of their patients. This book is highly recommended for nurses and other members of multidisciplinary teams caring for neuroscience patients, and an essential text for specialist neuroscience areas." (British Journal of Neuroscience Nursing, 1 September 2011) "I have really enjoyed this book, it’s given me a greater understanding of neurological conditions and the nursing management of them. It will be most helpful to me in my current and future career." (1st year nursing student, Nottingham University)Table of ContentsContributor List. Preface. Acknowledgements. Section I: Anatomy and Physiology of the Nervous System 1 Cells of the CNS and How They Communicate (Colm Treacy). 2 The Structural and Biochemical Defences of the CNS (Ehsan Khan). 3 The Anatomy and Physiology of the Brain (Chris Eberhardie, Sue Woodward and Ann-Marie Mestecky). 4 The Spinal Cord (Maureen Coggrave). 5 The Autonomic Nervous System (Chris Brunker). 6 Intracranial Physiology (Ann-Marie Mestecky). Section II: Assessment, Interpretation and Management of Specific Problems in the Neurological Patient. 7 Assessment and Management of Raised Intracranial Pressure (Ann-Marie Mestecky). 8 Assessment, Interpretation and Management of Altered Consciousness (Neal Cook and Sue Woodward). 9 Assessment, Interpretation and Management of Impaired Cognition (Thom Aird). 10 Assessment and Management of Challenging Behaviour (Mary Braine). 11 Assessment, Interpretation and Management of Altered Perceptual, Motor and Sensory Function (Iain Bowie and Sue Woodward). 12 Assessment, Interpretation and Management of Altered Speech and Swallowing (Jane Dundas and Kathryn Chappell). 13 Assessment, Interpretation and Management of Cranial Nerve Dysfunction (Iain Bowie and Sue Woodward). 14 Assessment, Interpretation and Management of Altered Cardiovascular Status in the Neurological Patient (Chris Brunker). 15 Assessment, Interpretation and Management of Impaired Respiratory Function in the Neurological Patient (Anne Mcleod). 16 Assessment and Management of Fluid, Electrolytes and Nutrition in the Neurological Patient (Neal Cook and Ann-Marie Mestecky). 17 Assessment and Management of Pain (Sue Woodward). 18 Assessment and Management of Bladder and Bowel Problems (Mandy Wells, Deborah Yarde and Sue Woodward). Section III: Neurological Investigations and Neurosurgical Procedures. 19 Neurological Investigations (Jane Connor and Kirsty Andrews). 20 Common Neurosurgical Procedures (Anne Preece). Section IV: Management of Patients with Intracranial Disorders and Disease 21 Management of Patients with Intracranial Tumours (Emma Townsley). 22 Management of Patients with Stroke and Transient Ischaemic Attack (Jane Dundas, Beverley Bennett and Julia Slark). 23 Management of Patients with Intracranial Aneurysms and Vascular Malformations (Ann-Marie Mestecky). 24 Management of Patients with Central Nervous System Infections (Ava Easton, Stephen Pewter, Huw Williams, Leann Johnson, Ed Wilkins and Ann-Marie Mestecky). 25 Management of Patients with Hydrocephalus (Stuart Hibbins). Section V: Management of Patients with Long-Term Conditions. 26 Management of Patients with Common Movement Disorders (Liz Scott, Pauline McDonald and Rachel Taylor). 27 Management of Patients with Motor Neurone Disease (Mary O’Brien). 28 Management of Patients with Multiple Sclerosis (Vicki Matthews and Nikki Embrey). 29 Management of Patients with Dementias (Katy Judd, Karen Harrison and Ian Weatherhead). 30 Management of Patients with Epilepsy (Anthony Linklater). 31 Management of Patients with Myasthenia Gravis (Saiju Jacob). Section VI: Management of Patients Following Head and Spinal Trauma. 32 Management of Patients with Traumatic Brain Injury (Siobhan McLernon). 33 Management of Patients with Spinal Injury (Paul Harrison and David Ash). Section VII: Management of Patients with Neuropathies and Spinal Disorders and Disease. 34 Management of Patients with Disorders of the Vertebral Column and Spinal Cord (Cath Waterhouse and Glynis Pellatt). 35 Management of Patients with Guillain-Barré Syndrome and Other Peripheral Neuropathies (Sue Woodward). Section VIII: Fundamental Concepts of Neuroscience Nursing. 36 Ethical and Legal Issues (Stephen Leyshon and Alison Hobden). 37 The History and Development of Neuroscience Nursing (Thom Aird). Index.
£49.35
John Wiley and Sons Ltd Neurovascular Examination
Book SynopsisThe use of neurovascular ultrasound is of increasing importance in neurological practice, both for radiologists and increasingly by neurologists themselves. Written by the world's most renowned expert, this book explains ultrasound examination of a stroke patient scanning protocols interpretation of the results Case examples (with a standard template presentation correlating presentation to waveform output) reinforce the book''s practical nature. Illustrated with photos of the tests, explanations, and with actual waveforms, images, and result interpretation, and enhanced with ''pearls'' and ''avoiding pitfalls'' features, it is a practical reference for those learning ultrasound as well as those using ultrasound in their practices.Table of ContentsForeword, vii Preface, ix Acknowledgment, xi Abbreviations, xiii 1 Understanding the Mechanisms and Dynamics of Cerebrovascular Events, 1 2 Time Is Brain and Brain Is Flow!, 27 3 The Power of Observation, 39 4 Applied Principles of Ultrasound Physics, 55 5 Applied Principles of Hemodynamics, 71 6 Real-Time Ultrasound Measures, 91 7 Emergent Examination, 113 8 Diagnostic Waveforms and Algorithms, 129 9 Differential Diagnosis, 151 10 Integration of Information and Case-Based Problem Solving, 177 Index, 197
£80.96
John Wiley and Sons Ltd Parkinsonian Disorders in Clinical Practice
Book SynopsisThis book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails - a challenge that clinicians will face for many years to come.Table of ContentsPreface. Introduction. 1 What is Parkinson’s disease? From pathophysiology to symptoms (Andreas Hartmann, Yves Agid, Anthony Schapira). I. Pathophysiology of Parkinson’s disease. 1. Dysfunctions of the main neuronal pathways in Parkinson’s disease. a. An overview of neuronal systems affected in Parkinson’s disease. b. Dopaminergic neurons. c. Non-dopaminergic neurons. 2. Consequences of dopaminergic neuronal lesions on basal ganglia circuits. a. The dopaminergic nigrostriatal system: pre- and postsynaptic compensatory mechanisms. b. Pathologic alterations of nigrostriatal circuits in Parkinson’s disease. 3. Histopathology of Parkinson’s disease. 4. The etiopathogenesis of Parkinson’s disease. a. The genetics of Parkinson’s disease: any clues for the sporadic forms? b. Relevant environmental factors: focus on mitochondria. c. Mechanisms of cell death in Parkinson’s disease: therapeutic implications. 5. Conclusions. a. Parkinson’s disease or Parkinson’s syndromes? b. What Parkinson’s disease is not. II. Clinical features of Parkinson’s disease. 1. Motor symptoms. 2. Non-motor symptoms. a. Depression. b. Apathy. c. Cognitive impairment. d. Sleep. e. Autonomic dysfunction. f. Sensory symptoms. 3. The different forms of Parkinson’s disease: relevance for prognosis. 4. The differential diagnosis of Parkinson’s disease. 5. Treatment-related symptoms. a. Motor complications. b. Non-motor complications. 2 Treatment of Parkinson’s disease (Anthony Schapira, Andreas Hartmann, Yves Agid). I. Antiparkinsonian agents. 1. Levodopa. 2. COMT inhibitors. 3. Dopamine agonists. 4. Monoamine oxidase B inhibitors. 5. Other drugs. II. Medical management. 1. Initiation of treatment. 2. Maintenance of treatment (Fig. 2.7). 3. Motor complications. 4. Management of non-motor complications. III. Non-medical management. 1. Surgery. 2. Destructive lesions. 3. Cell therapy. 4. Growth factors. IV. Neuroprotection. 1. MAO-B inhibitors. 2. Dopamine agonists. 3. Coenzyme Q. 4. Creatine. 5. Antiapoptotic drugs. V. Conclusion. 3 Case studies. Case studies—diagnostic index. Index.
£63.60
John Wiley and Sons Ltd Handbook of Epilepsy Treatment
Book SynopsisMake your way through the epilepsy maze Epilepsy is a complex neurological condition. There are many modern treatment options, and treatment should nowadays be tailored to an individual patient. But identification of the best therapy can be a labyrinthine process. The Handbook of Epilepsy Treatment provides a practical pathfinder for treating epilepsy based on published evidence and the author's 30 years of specialist clinical experience. Direct in style but comprehensive in content, with ample tables and summaries, the Handbook of Epilepsy Treatment covers: Treatment of the different forms and causes of epilepsy Treatment in the different commonly encountered clinical situations Treatment in children, in adults, in the elderly, in women, in epilepsy syndromes and in those with special needs and requirements Epilepsy drugs their pharmacology, kinetics, side effects, effectiveness and practical usage in the clinic<Trade Review"Handbook of Epilepsy Treatment is truly what the title promises: a very practice-oriented and useful handbook about the treatment of epilepsy. The updated edition is helpful for residents, fellows, general practitioners, and epileptologists alike." (Epilepsy & Behavior, 2 March 2011) "However, because antiepileptic drugs are frequently used off-label owing to difficulty in designing drug trials that meet Food and Drug Administration criteria for new indications, clinicians with familiarity in epilepsy treatment are likely to find the text and the insight of a seasoned practitioner a worthwhile addition to their libraries." (The Annals of Pharmacotherapy, 1 April 2011) "Shorvon (neurology, U. College London, UK) presents a comprehensive yet concise text for neurologists on the various treatments of epilepsy, both medical and surgical and in adults and children." (Booknews, 1 February 2011) "Handbook of Epilepsy Treatment is truly what the title promises: a very practice-oriented and useful handbook about the treatment of epilepsy. The updated edition is helpful for residents, fellows, general practitioners, and epileptologists alike." (Elsevier, 2 March 2011) "This is a very clearly written and nicely produced book, which is one of the best medium sized books on epilepsy currently available. I've no doubt that there will be demand for a 4th edition in a few years time." (Encephalitis Society, 1 April 2011) "The Handbook of Epilepsy Treatment provides a practical pathfinder for treating epilepsy based on published evidence and the authors 30 years of specialist clinical experience". (HPC Market Watch, 19 January 2011)Reviews of previous editions "This delightful new handbook...is excellent, well written, and practical...by one of the leading figures in clinical epilepsy today...This stylishly written book serves its purpose admirably. It is a superb handbook that will be of immediate value as a reference or review on the treatment of epilepsy for the general neurologist as well as for the experienced epileptologist" (Annals of Neurology) "...an excellent didactic tool and a very important hands-on text for all people involved in the care of epileptic patient. The factual information is easy to access, given the numerous tables that summarize the various sections, the comprehensive tabulation of data available, and the pharmacopeia appendix" (Child’s Nervous System) Table of ContentsPreface to the Third Edition. Acknowledgements. 1 Definitions and Epidemiology. Definitions. Frequency and population features of epilepsy. 2 Seizure Type and Anatomical Location of Seizures. Seizure type. Classifi cation of partial seizures by anatomical site of seizure onset. 3 Epilepsy Syndromes. ILAE Classifi cation of the Epilepsies and Epilepsy Syndromes. The epilepsy syndromes. 4 The Causes of Epilepsy. Idiopathic epilepsy. Symptomatic epilepsy of genetic or congenital origin. Symptomatic epilepsy due to acquired causes. Provoked seizures. 5 Principles of Treatment. Why treat epilepsy? The aims of treatment. The risks of epilepsy and its treatment. Choice of antiepileptic drug therapy based on seizure type. Treatment of specifi c epilepsy syndromes. Principles of treatment of newly diagnosed patients. Principles of treatment of patients with established active epilepsy. Treatment of patients with epilepsy in remission. Psychiatric disorders in epilepsy. Life-threatening idiosyncratic reactions. Complementary and alternative therapy in epilepsy. Genetic counselling in epilepsy. 6 Treatment of Epilepsy in Specifi c Groups. Treatment of epilepsy in children. Treatment of epilepsy in patients with additional handicaps. Epilepsy in elderly people. Treatment of epilepsy in women. 7 Pharmacokinetic Principles of Antiepileptic Drug Treatment. Drug absorption. Drug distribution. Drug elimination (metabolism and excretion). Blood level measurements. 8 The Antiepileptic Drugs. Carbamazepine. Clobazam. Clonazepam. Eslicarbazepine acetate. Ethosuximide. Gabapentin. Lacosamide. Lamotrigine. Levetiracetam. Oxcarbazepine. Phenobarbital. Phenytoin. Pregabalin. Primidone. Rufi namide. Tiagabine. Topiramate. Valproate. Vigabatrin. Zonisamide. Other drugs used in the treatment of epilepsy. Acetazolamide. Benzodiazepines. Corticosteroids and ACTH. Felbamate. Piracetam. Stiripentol. 9 The Emergency Treatment of Epilepsy. How to deal with a seizure. Status epilepticus. Antiepileptic drugs used in status epilepticus. 10 The Surgical Therapy of Epilepsy. Presurgical assessment – general points. Surgery in epilepsy arising in the mesial temporal lobe. Surgery in epilepsy arising in extratemporal regions and the temporal neocortex. Cortical dysplasia (malformations of cortical development). Surgery where no lesion is apparent on neuroimaging ('MRI-negative cases') Hemispherectomy, hemispherotomy and other large resections. Corpus callosectomy (corpus callosum section, corpus callosotomy). Multiple subpial transection. Vagal nerve stimulation. Other functional surgical procedures. The organization of epilepsy surgery care: the epilepsy surgery centre. Pharmacopoeia. Antiepileptic drugs – indications in epilepsy. Antiepileptic drugs – dose, average adult values. Antiepileptic drugs – dose, interactions. Antiepileptic drugs – dose, in children. Antiepileptic drugs – summary of side effects. Antiepileptic drugs – summary of metabolism. Antiepileptic drugs – summary of pharmacokinetic values (typical adult values). Antiepileptic drugs – modes of action. Further Reading. Index.
£63.60
Johns Hopkins University Press A Tour of the Senses
Book SynopsisThis entertaining introduction to sensory science is a clever mix of research findings and real-world stories that helps us understand the complex processes that turn sensory stimuli into sophisticated brain responses.Trade ReviewA fine guide recommended for health and science general-interest collections. Midwest Book Review When Henshaw told a casual acquaintance that he was writing a book about the senses, the response was 'The five senses?' He was quick to reply that there are more than five, and one goal of this book is to convince the reader that that is the case... One of the pluses of this book is its conversational tone and the use of anecdotes and examples. Choice A blend of research findings and real-world anecdotes about people's sensory experiences enlivens this historical view of the science behind perception. Science News This is an interesting book-an ideal gift for young biologists. -- Alan Cadogan The Biologist A Tour of the Senses is a fun book, which may be of interest to anyone who's ever wondered how the eye or ear works. -- Matthew R. Longo American Journal of Human BiologyTable of ContentsAcknowledgmentsIntroductionPart 1: Stimulus1. Electromagnetic Stimuli2. Chemical Stimuli3. Mechanical Stimuli4. The Science of SensationPart 2: Sensation5. Vision6. The Chemical Senses7. The Mechanical SensesPart 3: Perception8. Remembering the Present9. Perception and Culture10. Perception and EducationBibliographyIndex
£25.20
Johns Hopkins University Press How Literature Plays with the Brain
Book SynopsisExamines the parallels between certain features of literary experience and functions of the brain. For the neuroscientific community, this book suggests that different areas of research - the neurobiology of vision and reading, the brain-body interactions underlying emotions - may be connected to a variety of aesthetic and literary phenomena.Trade ReviewArmstrong's book is a testament to the value of the arts and the humanities since their processes and productions generate ideas that are literally the physical (neurobiological) stuff of which we are made. -- Gregory F. Tague ASEBL Journal How Literature Plays with the Brain: The Neuroscience of Reading and Art is a highly informative and carefully argued book. We recommend a close reading of it. Linguistic and Philosophical Investigations Armstrong's book is a beautiful example of how humanities scholars can accomplish a conversation across the gap between the 'two cultures' without giving up their disciplinary identity, bringing the larger picture to bear on the more particular research of the cognitive sciences. -- Karin Kukkonen Cambridge Quarterly Armstrong finds his inspiration in recent neuroscience... his overview of mirror neuron theory and the controversies that surround it, for example, outdoes in accuracy and judiciousness any other account I have seen among neuroaesthetics and cognitive literary studies. Modern Fiction Studies At present, when so many universities would gleefully discard the study of the arts in the service of a utilitarian turn in higher education, the evidence that Armstrong provides for their vital cognitive function and the coherence with which he presents that evidence is indeed both welcome and timely. Philosophy and Literature sTable of ContentsPreface1. The Brain and Aesthetic Experience2. How the Brain Learns to Read and the Play of Harmony and Dissonance3. The Neuroscience of the Hermeneutic Circle4. The Temporality of Reading and the Decentered Brain5. The Social Brain and the Paradox of the Alter EgoEpilogueNotesIndex
£25.17
Johns Hopkins University Press Dizziness
Book SynopsisEnhanced with patient stories and rounded out by a glossary of terms and an appendix describing home exercises, this is the go-to book for anyone who struggles with dizziness.Trade ReviewThis would be a brilliant read for medical students and primary care physicians. The simplified, common-sense approach, I found, made it compulsive reading, in a subject where that is the exception... It is [an] excellent value indeed. Journal of Laryngology & Otology [A] comprehensive new book. -- Jane Brody New York Times The two doctors simplify explanations of these matters, creating a survey that is packed with insights and information. Donovan's Literary Services This book is practical and useful. Easy to read and understand without being patronising. Nursing TimesTable of ContentsPrefaceIntroductionPart I. Dizzy Spells That Occur with a Change in Position 1. Benign Paroxysmal Positional Vertigo (BPPV)2. Orthostatic HypotensionPart II. Dizzy Spells That Occur in Attacks but without Any Apparent Trigger3. Meniere's Disease 4. Migraine-associated DizzinessPart III. A Single Bout of Dizziness That Lasts for Days and Then Gradually Improves5. Vestibular Neuritis 6. Stroke and Transient Ischemic Attacks (TIAs)Part IV. Constant Dizziness That Lasts 24 Hours a Day for Months and Even Years7. Dizziness and Anxiety (Chronic subjective dizziness)8. Mal de debarquement Syndrome (MdDS)9. Dizziness Due to Loss of Vestibular Function in Both Ears10. Small Vessel Ischemic Disease of the Deep White MatterAppendix: Home Exercises GlossaryReferencesIndex
£29.70
Johns Hopkins University Press Dizziness
Book SynopsisEnhanced with patient stories and rounded out by a glossary of terms and an appendix describing home exercises, this is the go-to book for anyone who struggles with dizziness.Trade ReviewThis would be a brilliant read for medical students and primary care physicians. The simplified, common-sense approach, I found, made it compulsive reading, in a subject where that is the exception... It is [an] excellent value indeed. Journal of Laryngology & Otology [A] comprehensive new book. -- Jane Brody New York Times The two doctors simplify explanations of these matters, creating a survey that is packed with insights and information. Donovan's Literary Services This book is practical and useful. Easy to read and understand without being patronising. Nursing TimesTable of ContentsPrefaceIntroductionPart I. Dizzy Spells That Occur with a Change in Position 1. Benign Paroxysmal Positional Vertigo (BPPV)2. Orthostatic HypotensionPart II. Dizzy Spells That Occur in Attacks but without Any Apparent Trigger3. Meniere's Disease 4. Migraine-associated DizzinessPart III. A Single Bout of Dizziness That Lasts for Days and Then Gradually Improves5. Vestibular Neuritis 6. Stroke and Transient Ischemic Attacks (TIAs)Part IV. Constant Dizziness That Lasts 24 Hours a Day for Months and Even Years7. Dizziness and Anxiety (Chronic subjective dizziness)8. Mal de debarquement Syndrome (MdDS)9. Dizziness Due to Loss of Vestibular Function in Both Ears10. Small Vessel Ischemic Disease of the Deep White MatterAppendix: Home Exercises GlossaryReferencesIndex
£15.68
Johns Hopkins University Press Johns Hopkins Neurology
Book SynopsisDr. Daniel Drachman, along with various illustrious colleagues, details the development of the Johns Hopkins Neurology Department from its inception in 1969 to the present. This highly illustrated, full-color work documents major innovations over the past 50 years and their impact on the field of neurology with respect to imaging, immunology, stroke, molecular biology and genetics, epilepsy, neurodegenerative diseases, neurovirology, and information technology. The work is organized in 21 chapters, which contain insights into developments in the field along with profiles of leading alumni. A dedicated chapter features reflections from 105 alumni from the department.Table of ContentsForeword1. The Long Road to Independence: 1889-19692. Starting From Scratch: 19693. The Daniel B. Drachman Neuromuscular Division4. The Peripheral Neuropathy Group5. The Neurovirology Group6. The Johns Hopkins Multiple Sclerosis Center7. Movement Disorders8. Oncology9. The Division of Neuro-Visual and Vestibular Disorders10. Spinal Muscular Atrophy11. Cerebrovascular Disease: Advancing the Field12. Neuroimaging: Viewing the Future13. Amyotrophic Lateral Sclerosis (ALS)14. Child Neurology15. Epilepsy16. Cognitive Neurology17. Neurocritical Care Unit (NCCU)18. Neuropathology: The Molecular Neuroscience of Disease Mechanisms19. Expansion to Bayview20. The Alumni of Johns Hopkins Neurology21. 105 Reflections on the Department of Neurology from our AlumniAfterwordIndex
£51.78
Johns Hopkins University Press A Caregivers Guide to Communication Problems from
Book SynopsisAn all-in-one guide for helping caregivers of individuals with brain injury or degenerative disease to address speech, language, voice, memory, and swallowing impairment and to distinguish these problem areas from healthy aging. Advances in science mean that people are more likely to survive a stroke or live for many years after being diagnosed with a degenerative disease such as Parkinson's. But the communication deficits that often accompany a brain injury or chronic neurologic conditionincluding problems with speech, language, voice, memory, and/or swallowingcan severely impact quality of life. If you are a caregiver coping with these challenges, this all-in-one book can help you and your loved one. Written by a team of experts in speech-language pathology, each chapter focuses on a different aspect of caregiving and features relatable patient examples. Providing answers to common questions, definitions of complex medical terms, and lists of helpful resources, this book also: toTable of ContentsList of ContributorsAcknowledgmentsIntroductionBarbara O'Connor Wells and Connie K. PorcaroChapter 1. What's Her Name and Where Are My Glasses? The Ironies of Healthy AgingTeresa Signorelli PisanoChapter 2. Communication Is a Two-Way Street: Understanding and Coping with Unclear SpeechConnie K. PorcaroChapter 3. An Owner's Guide to a Healthy VoiceConnie K. PorcaroChapter 4. A Tough Pill to Swallow: Maintaining Good Nutrition When Swallowing Is DifficultBarbara O'Connor Wells and Marissa A. BarreraChapter 5. Are We Speaking the Same Language? Coping with Aphasia and Communication ChallengesBarbara O'Connor WellsChapter 6. Another Senior Moment, or Is It Something Else? Communicating with Those Who Have DementiaElizabeth RobertsChapter 7. Coping and Caring for Your Loved One and YourselfLea KaplounChapter 8. Using the Arts to Improve Communication and Quality of LifeFrederick DiCarloAbout the EditorsAppendix A. Voice IllustrationAppendix B. Alphabet Board ExampleAppendix C. Swallowing IllustrationAppendix D. Brain IllustrationIndex
£37.35
Johns Hopkins University Press A Caregivers Guide to Communication Problems from
Book SynopsisAn all-in-one guide for helping caregivers of individuals with brain injury or degenerative disease to address speech, language, voice, memory, and swallowing impairment and to distinguish these problem areas from healthy aging. Advances in science mean that people are more likely to survive a stroke or live for many years after being diagnosed with a degenerative disease such as Parkinson's. But the communication deficits that often accompany a brain injury or chronic neurologic conditionincluding problems with speech, language, voice, memory, and/or swallowingcan severely impact quality of life. If you are a caregiver coping with these challenges, this all-in-one book can help you and your loved one. Written by a team of experts in speech-language pathology, each chapter focuses on a different aspect of caregiving and features relatable patient examples. Providing answers to common questions, definitions of complex medical terms, and lists of helpful resources, this book also: toTable of ContentsList of ContributorsAcknowledgmentsIntroductionBarbara O'Connor Wells and Connie K. PorcaroChapter 1. What's Her Name and Where Are My Glasses? The Ironies of Healthy AgingTeresa Signorelli PisanoChapter 2. Communication Is a Two-Way Street: Understanding and Coping with Unclear SpeechConnie K. PorcaroChapter 3. An Owner's Guide to a Healthy VoiceConnie K. PorcaroChapter 4. A Tough Pill to Swallow: Maintaining Good Nutrition When Swallowing Is DifficultBarbara O'Connor Wells and Marissa A. BarreraChapter 5. Are We Speaking the Same Language? Coping with Aphasia and Communication ChallengesBarbara O'Connor WellsChapter 6. Another Senior Moment, or Is It Something Else? Communicating with Those Who Have DementiaElizabeth RobertsChapter 7. Coping and Caring for Your Loved One and YourselfLea KaplounChapter 8. Using the Arts to Improve Communication and Quality of LifeFrederick DiCarloAbout the EditorsAppendix A. Voice IllustrationAppendix B. Alphabet Board ExampleAppendix C. Swallowing IllustrationAppendix D. Brain IllustrationIndex
£18.45
Johns Hopkins University Press Seizures and Epilepsy in Children
Book SynopsisTable of ContentsIntroductionPart I. Why Do Seizures and Epilepsy Occur?Chapter 1. How the Brain Works: Keys to Understanding Seizures and EpilepsyChapter 2. The Kinds of Seizures and Where They Arise in the BrainPart II. Diagnosing Seizures and EpilepsyChapter 3. How Doctors Diagnose a Seizure and Decide What It Means for Your ChildChapter 4. How Doctors Evaluate and Think about a First SeizureChapter 5. Decision Making: Assessing Risks and Benefits after a Nonfebrile SeizureChapter 6. What to Do during a Second Big Convulsive SeizureChapter 7. Understanding Your Child's Tests: EEG, CT, and MRIChapter 8. The Epilepsies of Childhood I: Special PatternsChapter 9. The Epilepsies of Childhood II: Special CausesPart III. TreatmentChapter 10. Using MedicinesChapter 11. Rescue Medicine and Treatment of Status EpilepticusChapter 12. Ketogenic Diet TherapyChapter 13. Alternative and Complementary Therapies for EpilepsyChapter 14. Surgery and DevicesPart IV. Practical Issues of Living with EpilepsyChapter 15. Routine Medical Care and EpilepsyChapter 16. Comorbidities: Other Problems that Can Co-occur with EpilepsyChapter 17. From Infancy to College: Navigating the Educational SystemChapter 18. Playing, Sports Participation, and Other ActivitiesChapter 19. Driving and EpilepsyChapter 20. Devices, Apps, and WebsitesChapter 21. Insurance and Other Financial IssuesChapter 22. The Future: Epilepsy Care, Marriage, Pregnancy, and ChildrenPart V. Emotional and Psychological IssuesChapter 23. Initial Strategies and OverviewChapter 24. Psychological Strategies: Coping, Resilience, and CounselingChapter 25. Coping with Substantial DisabilityConclusionGlossaryIndex
£18.45
Johns Hopkins University Press Healing the Traumatized Brain
Book SynopsisTable of ContentsAcknowledgmentsIntroductionPart I: Brain Structure and Function1. The Inner Workings of the Brain2. The Structure of the Brain3. Types of Brain Injury4. Influences on Recovery after Brain InjuryPart II: Neural Plasticity5. The Idea of Plasticity6. Neuroplasticity and Recovery from Brain Injury7. Behavioral Therapy and Plasticity8. Stress Management and Plasticity9. Cognitive Rehabilitation and Plasticity10. Nutrition and PlasticityPart III: Emotional Problems Caused by the Traumatized Brain11. Depression and the Traumatized Brain12. Mania and the Traumatized Brain13. Anxiety and the Traumatized Brain14. PTSD and the Traumatized BrainPart IV: Behavioral Disorders Caused by the Traumatized Brain15. Psychosis and the Traumatized Brain16. Aggression and the Traumatized Brain17. Impulsivity and the Traumatized Brain18. Substance Use and The Traumatized Brain19. Apathy and the Traumatized Brain20. Sleep and the Traumatized BrainPart V: Cognitive Issues Caused by the Traumatized Brain21. Attention and the Traumatized Brain22. Memory and the Traumatized Brain23. Executive Function and the Traumatized Brain24. Language and the Traumatized BrainPart VI: The Traumatized Brain and the Other Symptoms25. Headaches and the Traumatized Brain26. Seizures and the Traumatized Brain27. Vision and the Traumatized Brain28. Balance and the Traumatized Brain29. Hormonal Abnormalities and the Traumatized BrainPart VII: The Traumatized Brain and the Future30. Repeated Brain Injuries31. Future Treatments: Brain Stimulation and PlasticityEpilogueGlossaryResourcesSuggested ReadingIndex
£40.95
Johns Hopkins University Press Healing the Traumatized Brain
Book SynopsisThe essential guide to recovering from concussion and other brain injuries. Recovering from a brain injury can be a challenging and prolonged process. Learn how to maximize your recovery from the effects of brain injuries with the guidance of Sandeep Vaishnavi, MD, PhD, and Vani Rao, MBBS, MD, two leading medical experts with extensive experience helping patients recover from concussion and other brain injuries. Healing the Traumatized Brain explains how the brain works, how injuries affect the brain, and how to use your brain's own power to recover. This detailed guide contains essential information on: The emotional, behavioral, mental, and physical effects following concussion and other brain injuries Medication options and lifestyle changes Practical strategies for healing, including stress management, behavioral therapy, and cognitive rehabilitation Neuroplasticity and nutrition as they affect recovery Behavioral disorders, balance disorders, and hormonal changes following concuTable of ContentsAcknowledgmentsIntroductionPart I: Brain Structure and Function1. The Inner Workings of the Brain2. The Structure of the Brain3. Types of Brain Injury4. Influences on Recovery after Brain InjuryPart II: Neural Plasticity5. The Idea of Plasticity6. Neuroplasticity and Recovery from Brain Injury7. Behavioral Therapy and Plasticity8. Stress Management and Plasticity9. Cognitive Rehabilitation and Plasticity10. Nutrition and PlasticityPart III: Emotional Problems Caused by the Traumatized Brain11. Depression and the Traumatized Brain12. Mania and the Traumatized Brain13. Anxiety and the Traumatized Brain14. PTSD and the Traumatized BrainPart IV: Behavioral Disorders Caused by the Traumatized Brain15. Psychosis and the Traumatized Brain16. Aggression and the Traumatized Brain17. Impulsivity and the Traumatized Brain18. Substance Use and The Traumatized Brain19. Apathy and the Traumatized Brain20. Sleep and the Traumatized BrainPart V: Cognitive Issues Caused by the Traumatized Brain21. Attention and the Traumatized Brain22. Memory and the Traumatized Brain23. Executive Function and the Traumatized Brain24. Language and the Traumatized BrainPart VI: The Traumatized Brain and the Other Symptoms25. Headaches and the Traumatized Brain26. Seizures and the Traumatized Brain27. Vision and the Traumatized Brain28. Balance and the Traumatized Brain29. Hormonal Abnormalities and the Traumatized BrainPart VII: The Traumatized Brain and the Future30. Repeated Brain Injuries31. Future Treatments: Brain Stimulation and PlasticityEpilogueGlossaryResourcesSuggested ReadingIndex
£18.45
American Psychological Association Clinical Health Psychology in Medical Settings
Book SynopsisPracticing psychologists and professional graduate students will find this classic guide invaluable in developing specialized expertise in clinical health psychology.Table of ContentsPrefaceAcknowledgments Introduction to Clinical Health Psychology Becoming a Clinical Health Psychologist Clinical Health Psychology Assessment Intervention Strategies in Clinical Health Psychology Pitfalls in Practice Ethical Issues in the Practice of Clinical Health Psychology Liability Risks in Clinical Health Psychology: Malpractice Claims and Licensing Board Complaints Future Issues for Clinical Health Psychology Appendices Medical Abbreviations Journals Relevant to Clinical Health Psychology Professional and Disease-Specific Organizations Medical Problems That May Present With Psychological Symptoms ReferencesAuthor IndexSubject IndexAbout the Authors
£29.70
John Wiley and Sons Ltd Neurological Disorders due to Systemic Disease
Book SynopsisA wide range of common neurological presentations can result from systemic diseases A practical guide which guides the physician in the challenge of differentiating between a neurological deficit and a systemic illness Structured by neurological dysfunction Practical approach with algorithms and tips.Trade Review“The book presents a practical approach to the diagnosis and management of neurological syndromes in the contexts of systemic disease, and should be on every neurologist’s desk.” (European Journal of Neurology, 22 April 2013) Table of ContentsList of contributors, vii Preface, ix 1 Introduction, 1Steven L. Lewis 2 Headache due to systemic disease, 3Kevin A. Kahn 3 Encephalopathy (delirium) due to systemic disease, 29Allison Weathers 4 Dementia and systemic disorders, 51Jennifer R. Molano & Brendan J. Kelley 5 Stroke due to systemic diseases, 77Sarkis Morales-Vidal & Jose Biller 6 Seizures due to systemic disease, 107Matthew T. Hoerth & Joseph I. Sirven 7 Neuro-ophthalmology of systemic disease, 127Matthew J. Thurtell & Janet C. Rucker 8 Neuro-otology of systemic disease, 145Terry D. Fife 9 Movement disorders due to systemic disease, 155Brandon R. Barton & Christopher G. Goetz 10 Myelopathies due to systemic disease, 175Sital V. Patel & Steven L. Lewis 11 Peripheral nerve disorders in systemic disease, 192Michelle L. Mauermann & Ted M. Burns 12 Neuromuscular junction disorders due to systemic disease, 214Jaffar Khan 13 Myopathies due to systemic disease, 224Hannah R. Briemberg 14 Autonomic manifestations of systemic disease, 239Brent P. Goodman & Eduardo E. Benarroch 15 Sleep disorders and systemic disease, 261Erik K. St. Louis Index, 283 Color plate section can be found facing page, 86
£87.26
MP-WBK World Bank Group Publ Disease Control Priorities Third Edition Volum
Book Synopsis
£26.96
University of Toronto Press A Triune Concept of the Brain and Behaviour
Book SynopsisThis book reveals emerging theory in the nebulous area between neurophysiology and behavioural science which is of such vital importance in the mental health field. Part I of the book contains the three Hincks Memorial Lectures given by Dr. MacLean: 'Man's Reptilian and Limbic Inheritance,' 'Man's Limbic Brain and the Psychoses,' and 'New Trends in Man's Evolution.' Dr. MacLean emphasizes that the primate forebrain has evolved and expanded along lines of three basic patterns characterized as reptilian, paleo-mammalian, and neo-mammalian. Radically different in structure and chemistry, the three evolutionary formations comprise, so to speak, a triune brain. Dr. MacLean focuses on the intermediary role of the paleo-mammalian brain (limbic system), describing clinical and experimental observations that are relevant to understanding brain mechanisms involved in emotional and sexual behaviour, personal identity, memory, dreaming, and certain psychoses. Part II contains four
£17.99
Springer Sleep Disorders Medicine
Book Synopsis Table of ContentsSECTION I: BASIC SCIENCE OF SLEEPCh1: Introduction to the TopicCh2: Overview of Normal SleepCh3: Sleep Deprivation & Excessive Day Time SleepinessCh4: Effects of Sleep Deprivation and Sleepiness on Society and DrivingCh5: Neurobiology of REM Sleep, NREM Sleep Homeostasis, and Gamma Band OscillationsCh6: Basic Circadian Timing and Sleep-Wake RegulationCh7: Neurotransmitters and Neurochemistry of SleepCh8: Neurobiology of NREM Sleep and Thermoregulation in SleepCh9: Phylogeny of SleepCh10: Sleep and Anesthesia: Similar Pathophysiological ConcernsCh11: Physiological Changes of SleepCh12: Sleep and Immune RegulationCh13: Sleep and Memory ConsolidationCh14: Dreaming and Sleep DisorderCh15: Principles of Statistical ApplicationSECTION II: TECHNICAL CONSIDERATIONSCh16: Instrumentation, Electronics and Signal Analysis Ch17: An Overview of Polysomnographic TechniqueCh18: Electroencephalography, Electromyography, and Electro-Oculography: General Principles and Basic TechnologyCh19: Electrocardiography: Principles and Applications in Sleep MedicineCh20: Evaluation and Monitoring of Respiratory FunctionCh21: Neuroimaging in Normal and Abnormal SleepCh22: Multiple Sleep Latency TestCh23: Maintenance of Wakefulness TestCh24: Scoring of Normal Sleep and ArousalsCh25: Scoring of Sleep-Related Breathing EventsSECTION III: CLINICAL TOPICSCh26: Approach to the Patient with Sleep ComplaintsCh27: International Classification of Sleep DisordersCh28: Epidemiology: Principles and Application in Sleep MedicineCh29: Genetics of Sleep and Sleep DisordersCh30: Nutrition and SleepCh31: Sleep Duration, Morbidity and MortalityCh32: Obstructive Sleep Apnea SyndromeCh33: Central Sleep Apnea, Hypoventilation Syndrome and Sleep in High AltitudeCh34: Positive Airway Pressure in the Treatment of Sleep Apnea-HypopneaCh35: Preoperative, Perioperative and Postoperative Evaluation and Management of Sleep Disordered BreathingCh36: Oral Appliances and Surgical Techniques for Treatment of Obstructive Sleep Apnea SyndromeCh37: Nature, Evaluation and Treatment of InsomniaCh38: Narcolepsy and Idiopathic HypersomniaCh39: Motor Control and Dyscontrol in SleepCh40: Evaluation and Management of RLSCh41: Sleep, Breathing and Neurological DisordersCh42: Fatigue in Clincal PracticeCh43: Sleep, Coma, Vegetative and Minimally Conscious StatesCh44: Sleep and EpilepsyCh45: Dreaming in Neurological DisordersCh46: Sleep in Psychiatric DisordersCh47: Sleep Disturbances in General Medical DisordersCh48: Evaluation and Management of Circadian Rhythm Sleep DisordersCh49: Rapid Eye Movement Sleep Behavior DisorderCh50: ParasomniasCh51: Sleep Disorders in the ElderlyCh52: Evolution of Sleep from Birth to Adolescence and Sleep Disorders in ChildrenCh53: Sleep and Disorders in WomenCh54: Sleep, Violence and Forensic ImplicationsCh55: General Principle of Treatment of Sleep Dysfunction and Pharmacology of Drugs Used in Sleep DisordersCh56: Sleep and Alternative Medicine: ICh57: Sleep and Alternative Medicine: IICh58: Sleep in Extreme Environment
£251.99
University of Minnesota Press Unraveling: Remaking Personhood in a Neurodiverse
Book SynopsisDeveloping a cybernetic model of subjectivity and personhood that honors disability experiences to reconceptualize the category of the human Twentieth-century neuroscience fixed the brain as the basis of consciousness, the self, identity, individuality, even life itself, obscuring the fundamental relationships between bodies and the worlds that they inhabit. In Unraveling, Matthew J. Wolf-Meyer draws on narratives of family and individual experiences with neurological disorders, paired with texts by neuroscientists and psychiatrists, to decenter the brain and expose the ableist biases in the dominant thinking about personhood. Unraveling articulates a novel cybernetic theory of subjectivity in which the nervous system is connected to the world it inhabits rather than being walled off inside the body, moving beyond neuroscientific, symbolic, and materialist approaches to the self to focus instead on such concepts as animation, modularity, and facilitation. It does so through close readings of memoirs by individuals who lost their hearing or developed trauma-induced aphasia, as well as family members of people diagnosed as autistic—texts that rethink modes of subjectivity through experiences with communication, caregiving, and the demands of everyday life. Arguing for a radical antinormative bioethics, Unraveling shifts the discourse on neurological disorders from such value-laden concepts as “quality of life” to develop an inclusive model of personhood that honors disability experiences and reconceptualizes the category of the human in all of its social, technological, and environmental contexts.Trade Review"Unraveling is a work of cultural reimagination. Matthew J. Wolf-Meyer knits together neurological, psychiatric, and neuroscientific theories about ‘the brain’ in this broad-based inquiry into ‘communicative disorders.’ He insists that the many possibilities and blocked channels of communication depend on the interdependency of subject, personhood, family, community, and polity. He joins leading scholars in disability studies and feminist theory, illuminating the thoroughly social nature of all embodied communication and thus its ethical and political reliance on making a world where differences are welcome."—Rayna Rapp, New York University"This is a book for our times—a deep dive into the problematics of personhood in relationship to the neurological. This book, alluringly readable, vigorously challenges our conceptions of what makes a human being human and advocates for an anti-neoliberal vision of complex selfhood that is not dependent on predictable norms. While this subject could lend itself to predictable advocacy, Matthew J. Wolf-Meyer stays ahead of the reader's assumptions and provides a new and thoughtful way of conceiving big questions concerning the very definitions of life, thought, value, and ethics. A must read for anyone interested in neurodivergence and disability in general."—Lennard J. Davis, author of Obsession: A HistoryTable of ContentsContentsPreface: Blind-Man-and-WorldIntroduction: Let’s Build a New Nervous System1. Neurological Subjectivity: How Neuroscience Makes and Unmakes People through Neurological Disorder2. Symbolic Subjectivity: How Psychoanalysis and the Communication of Meaning Disable Individuals3. Materialist Subjectivity: How Technology and Material Environments Make Personhood Possible4. Cybernetic Subjectivity: The Fusion of Body, Symbol, and Environment in the Facilitated Person5. Facilitated Subjectivity, Affective Bioethics, and the Nervous SystemEpilogue: Living and Dying in the Nervous System AcknowledgmentsNotesIndex
£77.60
Brookes Publishing Co Genetics and Mental Retardation Syndromes: A New
Book SynopsisThis comprehensive resource offers an explanation of genetic mental retardation syndromes and how they affect behaviour. Four major syndromes - Down, Williams, Fragile X and Prader-Willi - and several lesser-known syndromes are covered, with in-depth information on genetic causes, physical and medical features, speech and language issues, prevalence, cognitive profiles and adaptive and maladaptive behaviours. Researchers and practitioners - including mental health professionals, educators, speech-language pathologists and caregivers - should get the research-based information they need to improve individuals' educational, personal, occupational and residential situations and to create wider community inclusion.Table of ContentsToward Etiology-Based Work; Applying the New Genetics to Mental Retardation Syndromes; Down Syndrome; Williams Syndrome; Fragile X Syndrome; Prader-Willi Syndrome; Five Other Intriguing Syndromes; Next Steps for Research.
£33.96
American Occupational Therapy Screening Adult Neurologic Populations: A
Book SynopsisIn this era of managed health care and a focus on quality, the appropriate use of quick and cost-ef?cient screening methods has become critical in the assessment process. From brain injury to dementia, occupational therapists working with adults with neurological difficulties must be able to efficiently use various screening methods to pinpoint deficits and determine how they affect a client’s daily functioning.This update of the classic text is a functional, easy-to-understand instruction manual describing the most common screening methods for clients with neurological disorders. 10 primary areas of neurologic screening are presented: 1. Cognition 2. Vision 3. Perception 4. Sensation 5. Peripheral nerve function 6. Motor function (including deep tendon re?ex function) 7. Basal ganglia and cerebellar function (balance, postural control, automated movements) 8. Cranial nerve function 9. Dysphagia 10. Mental status. Each chapter includes functional implications of impairment, screening procedures, red flags (signs and symptoms), available in-depth assessments, and screening forms. Step-by-step instructions and extensive photographs guide clinicians through the screening process. Designed to allow therapists to easily identify possible impairment, document identi?ed dysfunction, and determine if further in-depth evaluation is warranted, this bestselling text is a valuable reference tool for students to take from the classroom to the clinic.
£999.99
John Wiley and Sons Ltd Imaging and the Aging Brain, Volume 1097
Book SynopsisAdvances in imaging are occurring at a brisk pace, and imaging techniques have great potential to act as pre-symptomatic predictors of disease as well as to chart the course of a disease. Neuroimaging has greatly advanced the understanding of brain function and its relationship to the anatomical substrate. This volume brings together internationally renowned imaging scientists, those studying the aging brain, industry experts, and clinicians to jointly examine the most current methods and their application to brain physiology, behavior, and age-related diseases. These reports explore new technologies, data from recent neuroimaging initiatives, and translational research applications. Topics covered include (1) in vivo imaging of molecules, cells, and networks throughout the lifespan, (2) cutting edge imaging technologies and studies of the physiology of aging, (3) translational application of neuroimaging, and (4) emerging technologies in the private sector. This volume is the proceedings of a meeting that celebrated the 25th anniversary of the American Federation for Aging Research and its longstanding history of philanthropy in the area of aging research. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a memberTable of ContentsForeword: Mony J. De Leon. Part I: In Vivo Imaging of Molecules, Cells, and Networks in Aging and Animal Models of Alzheimer's:. 1. Making New Memories: The Role of the Hippocampus in New Associative Learning: Wendy A. Suzuki. 2. Anatomical and Functional Phenotyping of Mice Models of Alzheimer’s Disease by MR Microscopy: Helene Benveniste, Yu Ma, Jasbeer Dhawan, Andrew Gifford, S. David Smith, Igor Feinstein, Congwu Du, Samuel C. Grant, and Patrick R. Hof. 3. Various Dendritic Abnormalities Are Associated with Fibrillar Amyloid Deposits in Alzheimer's Disease: Jaime Grutzendler, Kathryn Helmin, Julia Tsai, and Wen-Biao Gan. 4. Two-Photon Imaging of Astrocytic Ca2+ Signaling and the Microvasculature in Experimental Mice Models of Alzheimer’s Disease: Takahiro Takano, Xiaoning Han, Rashid Deane, Berislav Zlokovic, and Maiken Nedergaard. 5. Synaptic and Mitochondrial Morphometry Provides Structural Correlates of Successful Brain Aging: Carlo Bertoni-Freddari, Patrizia Fattoretti, Belinda Giorgetti, Yessica Grossi, Marta Balietti, Tiziana Casoli, Giuseppina Di Stefano, and Gemma Perretta. 6. Impaired Recognition Memory and Decreased Prefrontal Cortex Spine Density in Aged Female Rats: Maureen Wallace, Maya Frankfurt, Adolfo Arellanos, Tomoko Inagaki, and Victoria Luine. 7. Alzheimer Amyloid β-Peptide A-β25−35 Blocks Adenylate Cyclase-Mediated Forms of Hippocampal Long-Term Potentiation: Blaine E. Bisel, Kristen M. Henkins, and Karen D. Parfitt. 8. Age-Related Changes in Neuronal Susceptibility to Damage: Comparison of the Retinal Ganglion Cells of Young and Old Mice Before and After Optic Nerve Crush: Ai Ling Wang, Ming Yuan, and Arthur H. Neufeld. Part II: In Vivo Imaging of Human Aging and the Transition to Cognitive Impairment:. 9. Top-Down Modulation and Normal Aging: Adam Gazzaley and Mark D'Esposito. 10. Brain Aging and Its Modifiers: Insights from in Vivo Neuromorphometry and Susceptibility Weighted Imaging: Naftali Raz, Karen M. Rodrigue, and E. Mark Haacke. 11. Linking Brain Imaging and Genomics in the Study of Alzheimer's Disease and Aging: Eric M. Reiman. 12. Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer’s Disease: M. J. De Leon, L. Mosconi, K. Blennow, S. Desanti, R. Zinkowski, P. D. Mehta, D. Pratico, W. Tsui, L. A. Saint Louis, L. Sobanska, M. Brys, Y. Li, K. Rich, J. Rinne, and H. Rusinek. 13. Functional MRI Studies of Associative Encoding in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease: Reisa Sperling. 14. Quantitative EEG and Electromagnetic Brain Imaging in Aging and in the Evolution of Dementia: Leslie S. Prichep. 15. [123I]5-IA-85380 SPECT Imaging of β2-Nicotinic Acetylcholine Receptor Availability in the Aging Human Brain: Effie M. Mitsis, Kelly P. Cosgrove, Julie K. Staley, Erin B. Frohlich, Frederic Bois, Gilles D. Tamagnan, Kristina M. Estok, John P. Seibyl, and Christopher H. Van Dyck. 16. Role of Aerobic Fitness and Aging on Cerebral White Matter Integrity: Bonita L. Marks, David J. Madden, Barbara Bucur, James M. Provenzale, Leonard E. White, Roberto Cabeza, and Scott A. Huettel. 17. Age-Related Changes in Nociceptive Processing in the Human Brain: Raimi L. Quiton, Steven R. Roys, Jiachen Zhuo, Michael L. Keaser, Rao P. Gullapalli, and Joel D. Greenspan. 18. Magnetic Resonance Spectroscopy and Environmental Toxicant Exposure: Marc G. Weisskopf. Part III: Diagnostic Applications of Imaging to Alzheimer's Disease:. 19. Tracking Alzheimer's Disease: Paul M. Thompson, Kiralee M. Hayashi, Rebecca A. Dutton, Ming-Chang Chiang, Alex D. Leow, Elizabeth R. Sowell, Greig De Zubicaray, James T. Becker, Oscar L. Lopez, Howard J. Aizenstein, and Arthur W. Toga. 20. Shifting Paradigms in Dementia: Toward Stratification of Diagnosis and Treatment Using MRI: Wiesje M. Van Der Flier, Frederik Barkhof, and Philip Scheltens. 21. Imaging-Guided Microarray: Isolating Molecular Profiles That Dissociate Alzheimer's Disease from Normal Aging: Ana Carolina Pereira, William Wu, and Scott A. Small. 22. Fibrillar and Oligomeric β-Amyloid as Distinct Local Biomarkers for Alzheimer's Disease: Michael C. Montalto, Gill Farrar, and Cristina Tan Hehir. 23. Diffusion Tensor Imaging of Normal Appearing White Matter and Its Correlation with Cognitive Functioning in Mild Cognitive Impairment and Alzheimer's Disease: Juebin Huang and Alexander P. Auchus. 24. Enhanced Ryanodine-Mediated Calcium Release in Mutant PS1-Expressing Alzheimer's Mouse Models: Grace E. Stutzmann, Ian Smith, Antonella Caccamo, Salvatore Oddo, Ian Parker, and Frank Laferla. 25. Prospects for Prediction: Ethics Analysis of Neuroimaging in Alzheimer's Disease: J. Illes, A. Rosen, M. Greicius, and E. Racine. Index of Contributors.
£96.30
John Wiley and Sons Ltd The Brain and Obesity, Volume 1264
Book SynopsisThe prevalence of obesity has dramatically increased over the last 25 years. In the United States, it is estimated that two-thirds of the population is either overweight or obese. This increase will undoubtedly continue to have profound medical, economic, and psychosocial consequences. As obesity and its medical complications become more common, novel inter-disciplinary approaches are emerging to help understanding the complex regulation of eating behavior and body weight. Although the notion that the brain is critical in regulating food intake and body weight is becoming more commonly accepted, innovative ideas examining this complex relationship must be pursued. Stemming from a 2007–2008 lecture series at the National Institute of Diabetes and Digestive Kidney Diseases, this Annals volume presents a series of up-to-date reviews that evaluate the role played by the brain in body weight regulation. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsThe Brain and Obesity Lectures Series - the beginning of a new field? Giovanni Cizza Kristina I. Rother vii Conjectures on some curious connections among social status, calorie restriction, hunger, fatness, and longevity Kathryn A. Kaiser Daniel L: Smith David B. Allison 1 Role of the blood-brain barrier in the evolution of feeding and cognition William A. Banks 13 The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects Renato Pasquali 20 Food reward in the obese and after weight loss induced by calorie restriction and bariatric surgery Hans-Rudolf Berthoud Huiyuan Zheng Andrew C. Shin 36 Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health Sarah M. Rothman Kathleen J. Griffioen Ruiqian Wan Mark P. Mattson 49 Leptin action on nonneuronal cells in the CNS: potential clinical applications Weihong Pan Hung Hsuchou Bhavaani Jayaram Reas S. Khan Eagle Yi-Kung Huang Xiaojun Wu Chu Chen Abba J. Kastin 64 Brain orexin promotes obesity resistance Catherine Kotz Joshua Nixon Tammy Butterick Claudio Perez-Leighton Jennifer Teske Charles Billington 72 Visceral adipose tissue: emerging role of gluco- and mineralocorticoid hormones in the setting of cardiometabolic alterations Marco Boscaro Gilberta Giacchetti Vanessa Ronconi 87 The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control Selma Masri Loredana Zocchi Sayako Katada Eugenio Mora Paolo Sassone-Corsi 103 Interacting epidemics? Sleep curtailment, insulin resistance, and obesity ElianeA. Lucassen Kristina I. Rother Giovanni Cizza 110 Childhood obesity and sleep: relatives, partners, or both?-a critical perspective on the evidence David Gozal Leila Kheirandish-Gozal 135
£99.00
