Molecular biology Books
Oxford University Press The Way of the Cell Molecules Organisms and the Order of Life
Book SynopsisWhat is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world''s most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms - in particular, the supremely well-researched bacterium E. coli - because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist''s personal attempt to wring understanding from the tide of knowledge.Trade Review"The work is like a breath of fresh air in a scientific world otherwise obsessed with excessive reductionism."--BioEssays"Witty and erudite, this scientific book hails as a literary achievement. Comprehensive and up to date, Franklin Harold traces the roots--historical, thermodynamic, and biochemical--of today's biological revolution."--Lynn Margulis, co-author (with Dorion Sagan) of both What is Life? and What is Sex?"This book helps us understand why the search for answers to the riddle 'What is life?' is a noble quest."--Howard C. Berg, author of Random Walks in Biology
£18.49
Oxford University Press Principles And Problems In Physical Chemistry For Biochemists
Book SynopsisAimed at the biochemistry undergraduates, this physical chemistry textbook covers a range of matters in a student-friendly manner, with a mix of information followed by worked examples that facilitate the absorption of the topics. It contains problems along with answers at the back of the book.Trade Review"Remarkably efficient [at] putting across conceptually difficult material ... Principles and Problems will continue to be essential reading for biochemistry undergraduates." The Biochemist, June 2002Table of ContentsINTRODUCTION ; THE ENERGETICS OF CHEMICAL REACTIONS ; THE RATES OF CHEMICAL REACTIONS ; ATOMIC AND MOLECULAR STRUCTURE ; APPENDICES
£35.99
Oxford University Press, USA Building Bioinformatics Solutions 2nd edition
Book SynopsisThis book introduces the reader to all the key concepts and technologies needed to begin developing their own bioinformatics tools. The new edition includes more bioinformatics-specific content and a new chapter on good software engineering practices to help people working in teams.Table of Contents1. Introduction ; 2. Building Biological Databases with SQL ; 3. Beginning Programming in Perl ; 4. Numerical data analysis using R ; 5. Developing Web Resources ; 6. Software Engineering for Bioinformatics ; Appendix A: Using Command Line Interfaces ; Appendix B: Getting started with Apache HTTP Server ; Appendix C: Setting up a Linux Virtual Machine in Windows
£57.00
Oxford University Press The Neuron Cell and Molecular Biology
Book SynopsisThe Fourth Edition of The Neuron features newly updated chapters and scores of full-color figures, making it an ideal first course in the cell and molecular biology of nerve cells.Trade ReviewThe text is impressively modern, with up-to date information on the trendiest areas of neurobiology . . .the book is highly visual, with figures on virtually every page. The figures deserve special comment because they are a teacher's dream: simple and uncluttered, but conceptually powerful. Frankly, although the recommendation is often absurd, The Neuron is one of those books that really does belong on every shelf. * Nature *The format of each chapter is ideally suited for easy, enjoyable, and almost effortless learning . . . This is a superbly written and well-illustrated text covering all of the major aspects of neuroscientific knowledge . . . every neuroscientist should keep a copy handy. * Journal of Psychiatry and Neuroscience *This is a first-rate textbook for a course in cellular neurobiology for upper-level university students. My colleagues and I took it out on a shakedown cruise with a class of 250 undergraduates. The wind really caught their sails, and we sped quickly through it in the ten weeks of the academic quarter. The students appreciated the consistent clarity and the uniformity of style. The illustrations are highly conceptual and were easily understood . . . The up-to-date presentation of many exciting recent findings is a great strength. General principles are illustrated with a useful blend of data from vertebrate and invertebrate systems. * William S Messer, Jr., in The Quarterly Review of Biology *An outstanding, easily readable, and quite up-to-date overview of fundamental neurobiology. * Canadian Journal of Neurological Sciences *Table of ContentsPreface to the Fourth Edition ; I. Introduction ; 1. Signaling in the Brain ; 2. Form and Function in Cells of the Brain ; II. Electrical Properties of Neurons ; 3. Electrical Signaling in Neurons ; 4. Membrane Ion Channels and Ion Currents ; 5. Ion Channels Are Membrane Proteins ; 6. Ion Channels, Membrane Ion Currents, and the Action Potential ; 7. Diversity in the Structure and Function of Ion Channels ; III. Intercellular Communication ; 8. Intercellular Communication: How Neurons Communicate: Gap Junctions and Neurosecretion ; 9. Synaptic Release of Neurotransmitters ; 10. Neurotransmitters and Neurohormones ; 11. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels ; 12. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems ; 13. Sensory Receptors ; IV. Behavior and Plasticity ; 14. The Birth and Death of a Neuron ; 15. Neuronal Growth and Trophic Factors ; 16. Adhesion Molecules and Axon Pathfinding ; 17. Formation, Maintenance, and Plasticity of Chemical Synapses ; 18. Intrinsic Neuronal Properties, Neural Networks and Behavior ; 19. Learning and Memory
£102.00
Springer Molecular Biology and Biotechnology of Extremophiles
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£156.75
MIT Press Ltd Algorithms in Structural Molecular Biology
£67.73
£54.02
Yale University Press F233lix DHerelle the Origins of Molecular Biology
Book SynopsisFelix d'Herelle demonstrated the use and application of bacteria for biological control of insect pests. Drawing on family papers, archival sources, interviews, and d'Herelle's published and unpublished writings, William C. Summers tells the story of the scientist's life and work.Trade ReviewAwarded an honorable mention for the 1999 Professional/Scholarly Publishing Annual Award in the Biological Science category given by the Association of American Publisher. -- Scholarly Publishing Annual Award * Association of American Publishers, Professional/Scholarly Publishing Division *
£59.37
Springer Modern Methods in Analytical Morphology
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£112.12
Springer ADPRibosylation in Animal Tissues Structure Function and Biology of Mono ADPribosyl Transferases and Related Enzymes 419 Advances in Experimental Medicine and Biology
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£120.75
Springer Biodiversity Biomolecular Aspects of Biodiversity and Innovative Utilization
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£86.62
Springer Stable Isotope Ecology
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£85.49
Springer Molecular and Cell Biology of Neuropsychiatric Diseases
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£116.80
John Wiley & Sons Inc Culture of Immortalized Cells
Book SynopsisThis book provides both general methods and safety considerations for the immortalization of cells and specific procedures for the immortalization of mammary, kidney, and thyroid epithelia, hepatocytes, fibroblasts, chondrocytes, lymphocytes, astrocytes, and human umbilical vein endothelium.Table of ContentsPartial table of contents: Human Keratinocyte Immortalization: Genetic Basis and Role inSquamous Cell Carcinoma Development (E. Parkinson). Safety Procedures (J. Caputo). Mapping Human Senescence Genes Using Interspecific MonochromosomeTransfer (R. Newbold & A. Cuthbert). Development of Immortal Human Fibroblast Cell Lines (L. Mayne, etal.). Immortalization of Human Bronchial Epithelial Cells (R. De Silva,et al.). Thyroid Epithelium (D. Wynford-Thomas). B-Lymphocytes (B. Bolton & N. Spurr). Megakaryocyte Cell Lines from Transgenic Mice (K. Ravid). List of Suppliers. Index.
£152.06
Chiliagon Science Biological Physics Student Edition Energy Information Life
£26.59
Springer Genetics and Breeding of Ornamental Species
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£166.88
Springer Plant Genomes Methods for Genetic and Physical Mapping
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£120.75
Springer Molecular and Cell Biology of the Plant Cell Cycle
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£112.50
Springer Cell Culture Engineering IV
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£143.62
Springer In Vitro Haploid Production in Higher Plants Volume 5 Oil Ornamental and Miscellaneous Plants Current Plant Science and Biotechnology in Agriculture
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£123.49
Springer Selected Topics in Mass Spectrometry in the Biomolecular Sciences
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£195.75
Springer The Hepatocyte Review
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£170.99
Northern Bee Books Honey Bee Pests Predators and Diseases
£33.00
Big Mac Publishers Programming of Life
£11.50
Wholon Thinking Like a Phage
£24.51
Cambridge University Press Methods in Molecular Biophysics Structure
Book SynopsisCurrent techniques for studying biological macromolecules and their interactions are based on the application of physical methods, ranging from classical thermodynamics to more recently developed techniques for the detection and manipulation of single molecules. Reflecting the advances made in biophysics research over the past decade, and now including a new section on medical imaging, this new edition describes the physical methods used in modern biology. All key techniques are covered, including mass spectrometry, hydrodynamics, microscopy and imaging, diffraction and spectroscopy, electron microscopy, molecular dynamics simulations and nuclear magnetic resonance. Each method is explained in detail using examples of real-world applications. Short asides are provided throughout to ensure that explanations are accessible to life scientists, physicists and those with medical backgrounds. The book remains an unparalleled and comprehensive resource for graduate students of biophysics and Trade ReviewReview of first edition: '… a valuable contribution to the field. … There is nothing quite like it at the moment.' Sir Tom Blundell FRS, University of CambridgeReview of first edition: … one of the most comprehensive and highly relevant texts on biophysics that I have encountered in the last 10 years, clearly written and up-to-date … a must-have for biophysicists working in all lines of research …' Nikolaus Grigorieff, Brandeis University, MassachusettsReview of first edition: '… a wonderful up-to-date treatise on the many and diverse methods used … in the fields of molecular biophysics, physical biochemistry, molecular biology, biological physics and the new and emerging field of quantum nanobiology.' Karl J. Jalkanen, Quantum Protein Centre, Technological University of DenmarkReview of first edition: '… a valuable resource for novice and seasoned biophysicists alike.' Dan Minor, California Institute for Quantitative Biomedical Research, University of CaliforniaReview of first edition: '… the book I consult first when faced with an unfamiliar experimental technique. Both classic analytical techniques and the latest single-molecule methods appear in this single comprehensive reference.' Philip Nelson, University of Pennsylvania and author of Biological PhysicsReview of first edition: '… valuable both for students and research scientists.' Michael G. Rossmann, Hanley Professor of Biological Sciences, Purdue UniversityReview of first edition: 'A great achievement … awaits the student who reads this book … an excellent reference for the seasoned practitioner of biophysical chemistry.' Milton H. Werner, The Rockefeller UniversityReview of first edition: 'This well written, thorough, and elegantly illustrated book provides the connections between molecular biophysics and biology that every aspiring young biologist needs.' Stephen H. White, University of California at IrvineReview of first edition: '… I enthusiastically recommend Methods in Molecular Biophysics to anyone who wishes to know more about the techniques by which the properties of biological macromolecules are determined.' David Worcester, University of MissouriReview of first edition: 'A book that teaches the methods well, creates the intellectual framework of our understanding, and can guide the field. Earlier efforts by Cohn and Edsall, Tanford, Edsall and Wyman, and Cantor and Schimmel have served this important purpose in the past, but the advance of time and technology has diluted the force of these classic works in contemporary Biophysics, both in the teaching and the practices of the field. How welcome, then, a clearly written, thoughtful and modern text that will serve well, both in formal courses and as a reference. The authors have built each method from its fundamental premises and principles, have successfully covered an impressive span of topics, and will be rewarded by attention from an audience that hungers for the next defining text in Molecular Biophysics.' D. M. Engelman, Yale University, New HavenTable of ContentsPreface to the first edition; Preface to the second edition; Introduction; Part I. Biological Macromolecules and Physical Tools: 1. Macromolecules in their environment; 2. Macromolecules as physical particles; 3. Understanding macromolecular structures; Part II. Mass Spectrometry: 4. Mass and charge; 5. Structure function studies; Part III. Thermodynamics: 6. Thermodynamic stability and interactions; 7. Differential scanning calorimetry; 8. Isothermal titration calorimetry; 9. Surface plasmon resonance and interferometry-based biosensors; Part IV. Hydrodynamics: 10. Biological macromolecules as hydrodynamic particles; 11. Analytical ultracentrifugation; 12. Fluorescence depolarization; 13. Dynamic light scattering and fluorescence correlation spectroscopy; Part V. Optical Spectroscopy: 14. Visible and IR absorption spectroscopy; 15. Two-dimensional IR spectroscopy; 16. Raman scattering spectroscopy; 17. Optical activity and circular dichroïsm; Part VI. Optical Microscopy: 18. Light microscopy; 19. Single molecule manipulation and atomic force microscopy; 20. Fluorescence microscopy; 21. Single-molecule detection; 22. Single-molecule manipulation; Part VII. X-Ray and Neutron Diffraction: 23. The macromolecule as a radiation scattering particle; 24. Small-angle scattering and reflectometry; 25. X-ray and neutron macromolecular crystallography; Part VIII. Electron Diffraction: 26. Electron microscopy; 27. Three-dimensional reconstruction from two-dimensional images; Part IX. Molecular Dynamics: 28. Energy and time calculations; 29. Neutron spectroscopy; Part X. Nuclear Magnetic Resonance: 30. Distances and angles from frequencies; 31. Experimental techniques; 32. Structure and dynamics studies; Part XI. Medical Imaging: 33. Radiology and positron emission tomography; 34. Ultrasound imaging; 35. Magnetic resonance imaging; References; Index of eminent scientists; Subject index.
£64.35
Cambridge University Press The Physics of Cancer
Book SynopsisAddressing key aspects of cancer research from an interdisciplinary perspective and presenting analytical, quantitative and computational models, this book is a pedagogical introduction to cancer for physics students and researchers, as well as a reference text for cancer biologists interested in quantitative tools and approaches from physics.Trade Review'The Physics of Cancer explores a growing field and seeks to incorporate discussions pertaining to both the physics and biology of cancer. [The authors] provide readers with a refreshing perspective on cancer research. The volume not only offers a clear description of the fundamental biological concepts of cancer development and treatment, but also introduces readers with a physics background to the developing interdisciplinary field of the physics of cancer. This new field contributes to the understanding of many aspects of cancer studies, which include cancer stem cell phenotypic switching, cell sorting, mechanics of cancer cells, cell migration, cancer metastasis, etc. Due to the advanced nature of the topic, this book will serve as a good introductory level resource for physics researchers and graduate students who are interested in learning about this interdisciplinary field.' H. Zhou, Choice'La Porta and Zapperi's book isn't just light reading for curious physicists - it can also serve to guide interested researchers into a rich interdisciplinary area.' Guido D'Amico, CERN CourierTable of ContentsPreface; 1. Introduction to the cell; 2. The biology of cancer; 3. A modeling toolbox for cancer growth; 4. Vascular hydrodynamics and tumor angiogenesis; 5. Cancer stem cells and the population dynamics of tumors; 6. Biomechanics of cancer; 7. Cancer cell migration; 8. Chromosome and chromatin dynamics in cancer; 9. Control of tumor growth by the immune system; 10. Pharmacological approaches: old and new; 11. Outlook on the physics of cancer: a new interdisciplinary area; References; Index.
£55.99
de Gruyter Biofabrication
£65.25
John Wiley and Sons Ltd Reversal of Aging: Resetting the Pineal Clock
Book SynopsisThe body of research on the process of human aging has grown considerably in recent years, and the reports presented here explore a full range of approaches to this research, from the molecular and genetic to the cellular and organismic levels. The contributing scientists identify the processes of aging and find functional and mechanistic approaches that may delay, prevent, or arrest the progress of aging and those ailments generally linked to senescence, such as metabolic, cardiovascular, and autoimmune diseases. The investigation of various approaches to the prevention of aging will include efforts to mitigate the deleterious consequences of chemical pollution. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.Table of ContentsIntroduction: The Rotational Origin and State of the Whole: Its Relation to Growth, Fertility, Aging, Death, and Diseases: Walter Pierpaoli. Part I: The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals:. 1. Multiple Longevity Phenotypes and the Transition from Health to Senescence: Robert Arking. 2. From Molecular Biology to Anti-aging Cognitive-Behavioral Practices: The Pioneering Research of Walter Pierpaoli on the Pineal and Bone Marrow Foreshadows the Contemporary Revolution in Stem Cell and Regenerative Biology: W C Bushell. 3. Genetic Contribution to Aging: Deleterious and Helpful Genes Define Life Expectancy: J I Lao, C Montoriol, I Morer, and K Beyer. 4. The Nitric Oxide Theory of Aging Revisited: S M. McCann, C Mastronardi, A De Laurentiis, and V Rettori. 5. Immunoregulation of Cellular Life Span: Marguerite Kay. 6. Lunasensor, Infradian Rhythms, Telomeres, and the Chronomere Program of Aging: Alexey Olovnikov. 7. The Pineal Aging and Death Program: Life Prolongation in Pre-aging Pinealectomized Mice: Walter Pierpaoli and Daniele Bulian. 8. Aging as a Mitochondria-Mediated Atavistic Program: Can Aging Be Switched Off?: Vladimir P. Skulachev and Valter D. Longo. 9. The Myth and Reality of Reversal of Aging by Hormesis: Joan Smith Sonneborn. Part II: Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence:. 10. Protein Kinase C Signal Transduction Regulation in Physiological and Pathological Aging: Fiorenzo Battaini and Alessia Pascale. 11. Protection of Proteins from Oxidative Stress: A New Illusion or a Novel Strategy?: Alexander A. Boldyrev. 12. The Role of Hsp70 in Age-Related Diseases and the Prevention of Cancer: Ezra V. Pierpaoli. Part III: Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging:. 13. Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens: Vladimir N. Anisimov, Lev M. Berstein, Irina G. Popovich, Mark A. Zabezhinski, Peter A. Egormin, Margarita L. Tyndyk, Ivan V. Anikin, Anna V. Semenchenko, and Anatoli I. Yashin. 14. The Phenomenon of the Switching of Estrogen Effects and Joker Function of Glucose: Similarities and Relation to Age-Associated Pathology and Approaches to Correction: Lev M. Berstein, Evgenia V. Tsyrlina, Dmitry A. Vasilyev, Tatjana E. Poroshina, and Rina G. Kovalenko. 15. Immunomodulation by Immunopeptides and Autoantibodies in Aging, Autoimmunity, and Infection: J J Marchalonis, S F Schluter, R T Sepulveda, R R Watson, and D F Larson. Part IV: Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions:. 16. Age at Onset: An Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease: Katrin Beyer, José I. Lao, Pilar Latorre, and Aurelio Ariza. 17. The Neuronal and Immune Memory Systems as Supervisors of Neural Plasticity and Aging of the Brain: From Phenomenology to Coding of Information: Katica D. Jovanova-Nesic And Branislav D. Jankovic. 18. Hormones Are Key Actors in Gene X Environment Interactions Programming the Vulnerability to Parkinson's Disease: Glia as a Common Final Pathway: Bianca Marchetti, Pier Andrea Serra, Francesca L'episcopo, Cataldo Tirolo, Salvo Caniglia, Nuccio Testa, Serena Cioni, Florinda Gennuso, Gaia Rocchitta, Maria Speranza Desole, Maria Clorinda Mazzarino, Egidio Miele, and Maria Concetta Morale. 19. Neurodegenerative Diseases: A Common Etiology and a Common Therapy: Walter Pierpaoli. Part V: The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives:. 20. Clinical Perspectives for the Use of Melatonin as a Chronobiotic and Cytoprotective Agent: Daniel P. Cardinali, Analía M. Furio, and María P. Reyes. 21. Melatonin Influences on the Neuroendocrine-Reproductive Axis. 22. Beatriz Díaz López, E Díaz Rodríguez, Colmenero Urquijo, and C Fernández Álvarez. 23. Caloric Restriction Mimetics: The Next Phase: George S. Roth, Mark A. Lane, and Donald K. Ingram. 24. Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ: Christof Schomerus and Horst-Werner Korf. 25. Effects of Melatonin in Age-Related Macular Degeneration: Changxian Yi, Xiaoyan Pan, Hong Yan, Mengxiang Guo, And Walter Pierpaoli. 26. Effects of Melatonin in Perimenopausal and Menopausal Women: Our Personal Experience: G Bellipanni, F Di Marzo, F Blasi, and A Di Marzo. 27. Modulatory Factors of Circadian Phagocytic Activity: Monica L. Hriscu. 28. The Role of NF-B in Protein Breakdown in Immobilization, Aging, and Exercise: From Basic Processes to Promotion of Health: Marina Bar-Shai, Eli Carmeli, and Abraham Z. Reznick. Part VI: Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine:. 29. The "Multiple Hormone Deficiency" Theory of Aging: Is Human Senescence Caused Mainly by Multiple Hormone Deficiencies?: T Hertoghe. 30. Stress-Induced Hypocortisolemia Diagnosed as Psychiatric Disorders Responsive to Hydrocortisone Replacement: Suzie E. Schuder. 31. Use of Telomerase to Create Bioengineered Tissues: Jerry W. Shay and Woodring E. Wright. 32. Mind-Body Medicine: Stress and Its Impact on Overall Health and Longevity: L Vitetta, B Anton, F Cortizo, and A Sali. 33. Bio-Identical Steroid Hormone Replacement: Selected Observations from 23 Years of Clinical and Laboratory Practice: Jonathan V. Wright. Part VII: Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population:. 34. Can We Delay Aging? The Biology and Science of Aging: B Anton, L Vitetta, F Cortizo, and A Sali. 35. New Horizons for the Clinical Specialty of Anti-aging Medicine: The Future with Biomedical Technologies: Ronald Klatz. 36. The Need for Anti-aging Medicine: The Challenges Faced to Incorporate Preventative Medicine into the Clinic and into Society: Philip Micans. 37. Science Is a Never-Ending Quest: A Brief Critique and Appreciation of Stromboli IV: Novera "Herb" Spector
£101.65
Caister Academic Press The Cyanobacteria: Molecular Biology, Genomics and Evolution
£208.05
Northern Bee Books Instrumental/Artificial Insemination of Honey Bee Queens
£11.61
The Blackburn Press The Growing Plant Cell Wall: Chemical and Metabolic Analysis
£35.97
R Buckingham MD, Facp How Dancing Really Stops the Clock
£24.99
Springer Nature Switzerland AG Heart of the Matter: Key concepts in
Book SynopsisThis textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed. All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College’s BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine.Table of Contents- Cardiac Development and Congenital Heart Disease:Cardiac Development Biology – Early Mechanisms Cardiac Development Biology – Late Mechanisms Cardiomyocyte Structure and Function Cardiac Morphology – Anatomy of Congenital Heart Disease Common Congenital Abnormalities - The Science of Arrhythmia: Introduction to the Action Potential Ion transporters and their Properties Excitation Contraction Coupling Tachyarrhythmias Bradyarrhythmias - The Science of Heart Failure: Cardiac Contractility – Normal and Pathological Heart Failure – A Scientific Perspective Cardiomyopathy Therapeutics Novel Therapies - The Science of Vascular Disease: The Vasculature – Pharmacological Targets The Coagulation Cascade and its Therapeutic Modulation Cellular and Molecular Mechanisms of Atherosclerosis Cellular and Molecular Mechanisms of Angiogenesis Endothelial Function and Dysfunction
£71.24
Springer Nature Switzerland AG The Language of Living Matter: How Molecules
Book SynopsisThis book, by an eminent scientist and philosopher, provides strong evidence for the claim that language is a general principle of Nature, rooted exclusively in physical and chemical laws. The author’s radical idea inevitably leads us to view the essence, origin and evolution of life in a completely new light. It shifts the coordinates of our scientific world-view in favor of an overarching concept of language that is able to bridge the gap between matter and mind. At the same time, it removes a blind spot in the Darwinian concept of evolution. To justify this far-reaching idea, the book takes a long and deep look at our scientific and philosophical thinking, at language as such, at science’s claim to truth, and at its methods, unity, limits and perspectives. These are the cornerstones structuring the book into six thematically self-contained chapters, rounded off by an epilogue that introduces the new topic of Nature’s semantics. The range of issues covered is a testimony to how progress in the life sciences is transforming the whole edifice of science, from physics to biology and beyond. The book is aimed at a broad academic and general readership; it requires no mathematical expertise.Table of Contents1. Language: Gateway to the World2. Truth: The Regulative Principle of Cognition3. Methods: Ways of Gaining Knowledge4. Unity: The Deep Structure of Science5. Limits: Insights into the Reach of Science6. Perspectives: Designing Living Matter7. Epilogue: Nature’s SemanticsAuthor IndexSubject Index
£21.53
Springer Nature Switzerland AG A Complete Guide to Gene Cloning: From Basic to
Book SynopsisThis comprehensive guide to gene cloning provides beginning and advanced readers with the background, standard techniques, practical applications, and ethical and safety considerations in the field. A one-stop reference for students, researchers in academia and industry, and anyone interested in a thorough but accessible overview.Table of Contents1. The recombinant DNA technology era 1.1 Important timelines 1.2 Scientist and their contribution to recombinant DNA technology 1.3 Recent advances2. Vectors: Guide to gene delivery vehicles 2.1 Plasmid, Cosmid, Phasmid, Bacteriophage 2.2 YAC and BAC 2.3 Shuttle vector 2.4 Expression vector3. Gene isolation methods: Beginners guide 3.1 Isolation of genomic and PCR amplification 3.2 Gene synthesis 3.3 cDNA library 3.4 Genomic library4. Gene cloning strategies: overview 4.1 Restriction and ligation-based cloning 4.2 Ligation-independent cloning 4.3 PCR-based cloning4.4 Recombination-based cloning 4.5 Mating-Assisted Genetically Integrated Cloning5. DNA cutters and connecters in recombinant DNA technology 5.1 RM system 5.2 Restriction enzymes 5.3 Sequence specific, G+C content, Methylation 5.4 Elimination of RM in host6 Fundamental techniques of recombinant DNA transfer 6.1 Chemical transformation in Bacteria, Fungi and animal cell 6.2 Physical transformation in Bacteria, Fungi and animal cell 7. Screening of recombinants 7.1 Colony hybridisation 7.2 Antibiotic based screening 7.3 Colony PCR 7.4 Plasmid Miniprep 7.5 Southern blotting 7.6 DNA Sequencing 7.7 Protein expression SDS PAGE, western blotting8. Recent Trends and Advances 8.1 Basics of gene editing 8.2 Zinc finger nucleases 8.3 Transcription activators like effectors 8.4 RNA interference 8.4 CRISPR Cas system 8.5 Cre-lox mechanism9. Application of Recombinant DNA Technology 9.1 Health, Medical and Diagnostics, Pharmaceuticals, Agriculture, , Industry 9.2 Health: Gene therapy, Diagnostics, 9.3 Pharmaceuticals: Vaccines, Insulin, Antibiotics, antibodies 9.4 Environment: Bioremediation, Bio indicators 9.5 Industry: Enzyme 9.6 Agriculture: Yield improvement, tolerant plants, transgenic for secondary metabolites 10. Ethical and safety concerns of recombinant DNA technology 10.1 Questionable knowledge dissemination 10.2 Uncertainties about misuse of technology 10.3 Potential risk of engineered organisms
£94.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Pränatale Diagnostik und Therapie in Ethik,
Book SynopsisDieses Buch gibt einen Überblick über die aktuellen Möglichkeiten der Präimplantationsdiagnostik, der pränatalen Diagnostik und die intrauterinen Behandlungsmöglichkeiten.Neben den invasiven Methoden wurden in den vergangenen Jahren immer mehr pränatale nicht-invasive Untersuchungsmethoden etabliert, die als großer Fortschritt in der Pränatalmedizin angesehen werden: Bluttest auf Trisomie 21 Array-CGH (vergleichende Gen Hybridisierung) Ultraschall Weiterhin nehmen auch die Möglichkeiten intrauteriner Therapien zu: Chirurgische Eingriffe Medikamentöse Behandlungen Herausgeber und Autoren stellen nicht-invasive und invasive Methoden vor. Sie setzen sich neben der Beschreibung der Methoden kritisch mit ethischen und rechtlichen Aspekten auseinander und diskutieren Möglichkeiten und Grenzen.Trade Review“... Das Buch beschreibt sehr gut die Auswirkungen der modernen Pränataldiagnostik auf unser heutiges Leben aus medizinischer, ethischer und rechtlicher Sicht ...“ (Nicole Ferst, in: biomed Austria, Heft 1, 2015, S. 24)“... Es gibt einen breit angelegten Überblick über die aktuellen Möglichkeiten der Pränatalmedizin, sowohl die(nicht-invasive) Diagnostik als auch intrauterine Behandlungsmöglichkeiten betrefend, und richtet sich an Gynäkologen und Geburtshelfer, Pränatalmediziner,Perinatologen, Molekularmediziner, Genetiker, Ethiker und alle interessierten Personen ...” (in: BeB Informationen, Heft 54, Dezember 2014)Table of ContentsEinleitung.- Stand der Medizin: Ultraschalldiagnostik, Pränataldiagnostik in der Praxis.- Intrauterine fetale Chirurgie.- Ethische, soziale und rechtliche Fragen: Fetomaternale Operationen: Ethische Aspekte bei der Einführung innovativer Verfahren.- Ethische Probleme der Pränataldiagnostik: zur Ethik der Inanspruchnahme aus eudaimonistischer Perspektive.- Vorgeburtliches Leben - Rechtliche Überlegungen zur genetischen Pränataldiagnostik.- Pränatale Diagnostik - Zwischen Angebot und Nachfrage: Die Inanspruchnahme vorgeburtlicher Diagnostik: Entwicklungen, Motive und Emotionen.- Ein kritischer Zwischenruf zur Marktdynamik nichtinvasiver Pränataldiagnostik .- Konsequenzen für die Gestaltung des Gesundheitssystems: Interprofessionelle Kooperation im Kontext von Pränataldiagnostik.
£64.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Die molekulare Basis von Gesundheit: Wie
Book SynopsisLernen Sie, wie Sie durch die wissenschaftlichen Erkenntnisse der Selbstheilung und der Wechselwirkung zwischen Ernährung und Genom Ihre Gesundheit positiv beeinflussen können. Tauchen Sie ein in die Welt der Epigenetik, die Ihnen erklärt, wie Sie Ihre Gesundheit fördern und das Beste aus sich selbst herausholen können.Zunächst führt Sie das Werk in die molekularen Grundlagen ein, wie jede einzelne Zelle funktioniert und Information über ihre Umgebung verarbeitet. Letzteres hat sehr viel mit Epigenetik zu tun, die ein zentrales Thema in diesem Buch ist. Die Epigenetik, die für die Identität der mehr als 400 verschiedenen Zelltypen unseres Körpers entscheidend ist, hat auch einen dynamischen Aspekt. Sie lernen, wie intrazellulärer Signalübertragungswege über extrazelluläre Signale aktiviert werden und damit Transkriptionsfaktoren und Chromatin-modifizierenden Enzymen beeinflussen. Viele dieser Signale stammen direkt oder indirekt von unserer Ernährung. Letztere ist das wichtigste externe Signal, dem wir täglich ausgesetzt sind. Das führt zum zweiten zentralen Thema dieses Buches, der Nutrigenomik. Die Nahrung, die wir täglich zu uns nehmen, ist weit mehr als eine Ansammlung von Kohlenhydraten, Proteinen, Lipiden, Vitaminen und Mineralien, die Energie und Bausteine für unseren Körper liefert. Das faszinierende Fachgebiet der Nutrigenomik beschreibt die Wechselwirkung zwischen Nahrungsmolekülen, ihren Metaboliten und unserem (Epi)genom. Viele Nahrungsbestandteile, wie beispielsweise ungesättigte Fettsäuren, aktivieren direkt Transkriptionsfaktoren oder verursachen Veränderungen in den Konzentrationen von Metaboliten. Diese beeinflussen wiederum die Aktivität von Chromatin-modifizierenden Enzymen. Auf diese Weise „sprechen“ Moleküle unseres Frühstücks, Mittagessen oder Abendessen mit unserem Genom bzw. Epigenom.Tauchen Sie ein in die faszinierende Welt der Selbstheilung und Verantwortung für Ihre Gesundheit!Table of Contents1 Das menschliche Genom 1.1 Migration und evolutionäre Herausforderungen des Homo sapiens 1.2 Vielfalt menschlicher Populationen 1.3 Varianten des menschlichen Genoms 2 Epigenetik, Chromatin und Genexpression 2.1 Was ist Epigenetik? 2.2 Die epigenetische Landschaft 2.3 Nukleosomen: zentrale Einheiten des Chromatins 2.4 Chromatinarchitektur: Epigenetik in 3D 2.5 Chromatinorganisation 2.6 Epigenetik und Genexpression 3 Epigenetische Regulation 3.1 DNA-Methylierung 3.2 Genetische Prägung 3.3 Histone und ihre Modifikationen: der Histoncode 3.4 Genregulation über Chromatin-modifizierende Enzyme 3.5 Chromatinremodellierer 3.6 Lange ncRNA-Moleküle als Chromatinorganisatoren 4 Molekulare Sensoren von Makro- und Mikronährstoffen 4.1 Grundlagen des Stoffwechsels 4.2 Kohlenhydrate, Aminosäuren und Lipide 4.3 Kernrezeptoren als Nährstoffsensoren 4.4 Vitamine und ihre Rezeptoren 5 Nutrigenomik und Stoffwechselregulation 5.1 Nutrigenomik und Nutrigenetik 5.2 Epigenetische Signalübertragung von Metaboliten des Intermediärstoffwechsel 5.3 Zirkadiane Kontrolle von Stoffwechselprozessen 6 Ernährung und Volkskrankheiten 6.1 Evolution der menschlichen Ernährung 6.2 Ernährung und Stoffwechselerkrankungen 6.3 Ernährung und Krebs 6.4 Molekulare Auswirkungen von körperlicher Aktivität 6.5 Kalorienrestriktion und der zelluläre Energiestatus 7 Embryogenese und Zelldifferenzierung 7.1 Epigenetische Veränderungen während der Embryogenese 7.2 Stammzellen und zelluläre Pluripotenz 7.3 Epigenetische Dynamik während der Differenzierung 8 Das Immunsystem 8.1 Epigenetik der Hämatopoese 8.2 Akute und chronische Entzündungen 8.3 Die Rolle der Epigenetik bei Immunantworten 9 Fettleibigkeit und Diabetes 9.1 Fettleibigkeit 9.2 Entzündung im Fettgewebe 9.3 Metabolischer Stress im ER 9.4 Energiehomöostase und hormonelle Regulation der Nahrungsaufnahme 9.5 Glukosehomöostase und Insulinresistenz 9.6 β-Zell-Versagen und T2D 10 Herz-Kreislauf-Erkrankungen und das metabolische Syndrom 10.1 Bluthochdruck und Arteriosklerose 10.2 Lipoproteine und Dyslipidämien 10.3 Metabolisches Syndrom 11 Epigenetik von Krebs 11.1 Epimutationen bei Krebs 11.2 Epigenom-weite Störungen als Kennzeichen von Krebs 11.3 Epigenetische Umprogrammierung bei Krebs 11.4 Epigenetische Mechanismen von Krebs 12 Das zentrale Nervensystem 12.1 Die Rolle der Epigenetik bei der neuronalen Entwicklung 12.2 Epigenetische Grundlagen des Gedächtnisses 12.3 Epigenetik neurodegenerativer Erkrankungen 13 Ernährung und Altern 13.1 Evolutionäre Anpassungen des menschlichen Genoms 13.2 Generationsübergreifende epigenetische Vererbung 13.3 Konservierte nährstoffassoziierte Signalwege und das Altern 13.4 Epigenetik des Alterns 14 Der gesunde Lebensstil 14.1 Epigenom-weite Varianten 14.2 Personalisierte Medizin und Ernährung 14.3 Epigenetische Therapie von Krankheiten
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