Medicinal chemistry Books

Book SynopsisThe research on carbon dots is evolving and expanding very rapidly. A high-tech overview for academia and industry is needed to modernize carbon dots in biological applications. This book covers the use of carbon dots in biology, medicine, and pharmacy: synthesis, properties and applications, obstacles in exploiting these materials, and future research prospects. The reader is able to explore the wide scope of carbon dots in the global market.

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Book SynopsisWith the advancement in medicinal chemistry and material science, several highly specific, biocompatible and non-toxic therapeutic agents have been discovered and successfully applied for various clinical applications. Many of the conventional constraints of clinical therapies have been replaced and overcome by the multifaceted applications of material science and nanotechnology. Recently, material science-based therapeutic agents are the major global pharmaceutical market and are believed to mount exponentially shortly. Among the various therapeutic agents, hydrogels are one of the most widely applied materials used in the treatment of various diseases, and one of the most diverse materials that are used for multipurpose applications. Hydrogels were the first biomaterials used for Human being. Hydrogels are polymeric linkages, water-insoluble, however, sometimes established as a colloidal gel in water. Hydrogels are the superabsorbent materials because it can absorb more than 90% water, and hence regarded as natural living tissue. Mechanically strong hydrogels were synthesized by the advent of new synthetic strategies. Owing to the swollen properties, three-dimensional polymer network, and strong mechanical characteristics, these are widely used in catalysis, adsorption, drug delivery systems for proteins, contact lenses, wound dressings, wound healing, bone regeneration, tissue engineering, baby diapers, food rheology, and many others. Due to their diverse applications, hydrogels are considered one of the smartest materials in pharmaceutics, and are eco-friendly materials, cheap, and have good recyclability. They are used as therapeutic agents in different health sectors. As they are very sensitive to target, therefore it is considered favorite and preferred choice in biomedical sectors. Patients are psychologically scared of surgeries regarding huge expenses and failure. So researchers are working on hydrogels as alternative surgical replacement. In most cases, they have successfully achieved research on hydrogels in bones and tissues repairment. It might be hope of life for serious patients in future. The domain of this work will cover state of the art potentials and applications in various technological areas.

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Book Synopsis​Die auftretenden Varianten von SARS-CoV-2 beschleunigen durch ihre höheren Übertragungsraten die globale COVID-19-Pandemie, wodurch dringend neue therapeutische Angriffsziele benötigt werden. Hierbei wurde die antivirale Wirkung von Fluoxetin - einem Antidepressivum - gegen SARS-CoV-2 entdeckt. Mithilfe biochemischer und bildgebenden Methoden wurde der antivirale Wirkmechanismus von Fluoxetin näher analysiert und die saure Ceramidase als SARS-CoV-2 Wirtsfaktor charakterisiert. Veröffentlichte Studien zeigten, dass auch Aspirin eine antivirale Wirkung gegen Erkältungsviren, wie Rhinoviren und Influenzaviren zeigt. Diese antivirale Wirkung wurde in Bezug auf SARS-CoV-2 in Zellkultur und einem patienten-nahen 3D-Infektionsmodell untersucht und bestätigt. Um die Pathologie einer SARS-CoV-2-Infektion zu verstehen, wurde der Eintrittsweg des Virus in das Gehirn untersucht. Im Gegensatz zu anderen Viren überwindet SARS-CoV-2 die Blut-Hirnschranke ohne T-Zellen oder Makrophagen. Ebenso wurde der Einbau eines lipophilen Fluoreszenzfarbstoffs in die Virusmembran etabliert, womit die direkte Markierung verschiedener Viren trotz ihrer unterschiedlicher Membranzusammensetzung möglich ist. Mit superauflösender Mikroskopie (SIM) wurde der virale Eintritt verschiedener umhüllter Viren visualisiert.Table of ContentsEinleitung.- Materialien.- Methoden.- Ergebnisse.- Diskussion.- Eigene Publikationsliste.- Literaturverzeichnis.

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Book SynopsisThe pharmaceutical industry is currently facing a significant innovation deficit, despite the potential offered by advances in genomics, high throughput screening, and combinatorial and asymmetric synthesis for drug discovery. The number of new molecules registered annually has actually decreased, contrary to expectations, and post-marketing failures of blockbuster drugs have become a major concern. On the other hand, there is a growing global trend towards the use of traditional medicine, including complementary and alternative therapies. Ethnopharmacology and traditional medicines have played a significant role in the past in the discovery of natural products, and there are two clear areas where ethnopharmacology can make a significant contribution to future drug research. First, as a discovery engine for new targets, leads, and second, the use of quality-assured and standardized traditional medicines. This book provides a historical perspective, future prospects, and the significance of ethnopharmacology in drug research, as well as important steps in botanical drug discovery and development, including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability, with examples from ethnopharmacology and herbal medicine. The book also includes an excellent overview of Good Laboratory and Good Clinical Practices, as well as very useful summary steps for filing IND or NDA for botanical products. Additionally, the book provides the regulators perspective on validating claims and how ethnopharmacological or traditional medicines may require a different approach.

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Book SynopsisWhile biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.Table of ContentsSection I. Discovery: 1. Overview of medical and drug development. 2. TM/CAM and ethnopharmacology. 3. Natural product and drug discovery. 4. Innovation and drug discovery. 5. Bioprospecting and IPR. Section II. Development 6. Safety and regulatory issues. 7. Quality control and standardization. 8. Herbal pharmaceutics: stability and pharmacokinetics. 9. Preclinical and clinical evaluation. 10. Regulatory guidance to industry. 11. Validating of health claims and pharmacoepidemiology.Section III. Technology: 12. Biotechnology in herbal drug research. 13. Microarrays and high throughput screening. 14. Pharmacogenomics and ethnopharmacology. 15. Ethnoinformatics and AyuSoft. 16. Systems approaches and reverse pharmacology. 17. Future perspectives.

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Book SynopsisThis book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.Table of ContentsChapter 1: Historical Perspective of Drug Discovery and DevelopmentChapter2: Natural Products and Drug DiscoveryChapter 3: The Concept Of Receptors And Molecules Interaction In Drug Discovery And DevelopmentChapter 4: Chemical Structure and Stereochemistry Chapter 5:Biased Agonism:Renewing GPCR's targetabilityChapter 6: Computer Aided Drug DiscoveryChapter 7: Pharmacological screening of novel chemical entitiesChapter 8:Drug Target Identification and Validation:Chapter 9: Genetics and Drug DiscoveryChapter 10: Stem Cells and Therapeutics Chapter 11: Pharmacokinetics Chapter 12: Regulatory Toxicological TestingChapter 13: Nanotoxicology and Regulatory Requirements Chapter 14: Clinical Trials in Industrial Drug DevelopmentChapter 15:PharmacovigilanceChapter 16: Regulatory Process for New Drug Approval in IndiaChapter 17: Pharma Industry, Academia, Regulatory Authorities, and End-user Interaction in the Chapter 18: Statistics

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Book SynopsisThis book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.Table of Contents1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa.- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds.- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects.- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant.- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana.- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions.- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities.- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production.- 9 Saffron: A prized herb with therapeutic potential against diabetes.- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors.- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future.- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants.- 13 Production of anti-diabetic lignans in flax cell cultures.- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect.- 15 Cryopreservation of Anti-diabetic plants.

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Book SynopsisHumans have numerous microorganisms residing in the body, especially in the gut, far exceeding the human body's normal mammalian cells. Recent research links the gut microbiome, the population of microorganisms living in the gastrointestinal tract, with brain diseases. This volume explores the concept and possibility of its extension to manage a galaxy of CNS diseases, including Parkinson's, Alzheimer's, Autism spectrum disorders, depression, insomnia, and chronic fatigue syndrome. This volume elaborates about communication channels between gut and brain via the vagus nerve, short-chain fatty acids including omega acids, and other inflammasomes.In contrast to the available books on the topic, this title is more versatile and endeavors to bring together scientific pre-clinical, and clinical claims on the probable psychobiotic implication of probiotic therapy. The book will appeal similar to the general public, students, experienced researchers, and academicians. It is endeavored to address an aspect of probiotic usage beyond gut disorders. We hope that it would be helpful to people studying the human nervous system and related conditions with their treatments.Table of Contents

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Book SynopsisThis volume focuses on the potential use of probiotics in treating metabolic disorders such as diabetes mellitus, metabolic acidosis, and gut dysbiosis. Chapters draw an association between gut microbiota and its diversity with metabolic diseases like diabetes, obesity, related liver and gut disorders; gut-brain axis; increased inflammation, and a compromised immune system resulting from these manifestations and scope of intervention with probiotics. Special attention is laid on describing the mechanisms of action of such beneficial effects of probiotic administration. The ability of probiotics to decrease metabolic endotoxemia by restoring the disrupted intestinal mucosal barrier is also included.The volume is a comprehensive compilation describing the scope and application of probiotic and prebiotic therapy in treating metabolic disorders. Readers will discover how probiotics are not just confined to the microbiology industry but are showing promising results in the medical and pharmaceutical sectors.Table of Contents

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Book SynopsisThis textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.Table of ContentsChapter 1: Fundamentals of Pharmacokinetics.- Chapter 2: Drug absorption.- Chapter 3: The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding.- Chapter 4: Pharmacokinetic models and drug distribution.- Chapter 5: Drug metabolism .- Chapter 6: Drug elimination and nonlinear kinetics.- Chapter 7: Pharmacokinetic drug-drug interactions.- Chapter 8: Pharmacokinetic applications.- Chapter 9: Pharmacokinetic sample collection and processing.- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics.- Chapter 11: Statistics in pharmacokinetics.- Chapter 12: Pharmacokinetic software and tools.- Chapter 13: Pharmacokinetic laboratory-based experiments.- Chapter 14: Pharmacokinetic numerical problems with solutions.- Chapter 15: Questions, and questions & answers for practice.

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Book SynopsisThis book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It can be used as a reference book for students, teachers and researchers of biomedical field.Table of ContentsAntibody-Drug Conjugates Basic Concepts and Structures.- Relationship between target and specific action of antibody-drugs conjugates.- The internalization and therapeutic activity of antibody drug conjugate.- The internalization and intracellular trafficking of ADC.- Distribution and metabolism of antibody-drug conjugates.- Application of Antibody fragments in ADCs.- Novel Targeting Carriers in Antibody-drug Conjugates.- Site-specified Conjugating Technology and Application.- Determination of drug-to-antibody ratio of ADCs.- Pharmacokinetic study of antibody-drug conjugates.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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