Medical toxicology Books

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Book SynopsisIntroduction to the communication toxicology concept.- Large definition of communication endocrine paracrine, synapse, intracellular.- What have we learned from endocrine disruption.- Communication disruption in the nervous system.- Communication disruption in the immune system.- The exposome and its influence on toxicology.- Interaction between dietary imbalance and chemical toxicity.- Interaction between social stress and chemical toxicity.- Communication disruption in the balance between adaptation and toxicity.- Conclusion.

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Book SynopsisNanotoxicology probing established paradigms using innovative approaches.- Use of sensors to provide real time assessment of cellular responses to nanomaterials in in vitro systems.- Recreating physi logical events using advanced in vitro models.- Emerging strategies for nanosafety assessment the power of multiplexing.- Genotoxicity and Epigenetics How nanomaterials interact with DNA and gene expression.- Section Two Bridging in vitro in vivo models Assessing nanomaterial hazard with lower tier organisms, reducing reliance on rodent models and ensuring sustainability in nanosafety approaches.- Caenorhabditis elegans as a model organism to probe nanosafety from morphological to molecular approach.- Drosophila melanogaster a dynamic in vivo model to study nano bio interactions.- Zebrafish embryos as a tool for nanomaterials hazard assessment.- Daphnia as a model organism in econanotoxicity assessment from individual to population effects.- Organ on a chip and nanosafety The latest in vitro platforms to predict hazard and streamline nanosafety assessment.- Skin on a chip.- Lung on a chip.- Gut on a chip.- Systems on a chip.- Computational approaches to nanosafety From traditional QSAR to Artificial Intelligence and Life Cycle Assessment.- Leveraging Opportunities for Computer Aided Nanosafety Integrating Nano QSTR with AI Generalized Read Across Models.- Advanced Structure Based Docking Protocols for Complex Nano Mixtures Risk Assessment.- Building Multiple Machine Learning Classifiers to Address Nanomaterial Risks Assessment.- Life Cycle Assessment a broader view of nanomaterials beyond biological effects.

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Book SynopsisTable of ContentsPART 1. Legacy and emerging contaminants in marine mammal populations 1. Organochlorine contaminants and reproductive implication in cetaceans: A case study of the common dolphin 2. Feeding ecology tools to assess contaminant exposure in coastal mammals 3. The toxicological effects of oil exposure on cetaceans 4. Legacy contamination in estuarine dolphin species from the South American coast 5. Poly- and Perfluoroalkyl Substances in Marine Mammals 6. Marine debris interaction with marine mammals 7. Persistent organic pollutants in cetaceans living in a hotspot area: the Mediterranean sea 8. Pollutants in tropical marine mammals of the Galapagos Islands, Ecuador: An Ecotoxicological Quest to the Last Eden PART 2. Effects of toxicological and cumulative stress on marine mammal health 9. Field sampling techniques and ecotoxicological Biomarkers in cetaceans 10. Ecotoxicological biomarkers and accumulation of contaminants in pinnipeds 11. New technologies for monitoring marine mammal health 12. Immunotoxic effects of environmental pollutants in marine mammals 13. Ecotoxicological stress in Arctic marine mammals - with particular focus on polar bears 14. Toxicological Risks and Considerations Associated with Lipophilic Contaminant Burdens of Mysticetes in Antarctic Ecosystems 15. Emerging pathogens and stress syndromes of cetaceans in European waters: cumulative effects 16. Ecotoxicology of the Sirenia in the Twenty-First Century PART 3. Implication for monitoring and conservation of marine mammals 17. Marine mammals and multiple stressors, implications for conservation and policy

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Book SynopsisTable of ContentsSection I: Historical Perspective and Epidemiology 1. History of Toxicology: From Killers to Healers; 2. Historical Perspective of Chemical Warfare Agents; 3. Global Impact of Chemical Warfare Agents Used Before and After 1945; 4. Sarin Attacks in Japan: Acute and Delayed Health Effects in Survivors; 5. Early and Delayed Effects of Sulfur Mustard in Iranian Veterans After the Iraq–Iran Conflict; 6. Epidemiology of Chemical Warfare Agents; 7. Chemical Weapons of Mass Destruction and Terrorism: A Threat Analysis Section II: Agents That Can Be Used as Weapons of Mass Destruction 8. Organophosphate Nerve Agents; 9. Russian VX; 10. Novichoks; 11. Blister Agents; 12. Riot Control Agents; 13. Phosgene oxime; 14. Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate); 15. Fluoroacetate; 16. Strychnine; 17. Superwarfarins; 18. PCBs, Dioxins and Furans: Human Exposure and Health Effects; 19. Polycyclic Aromatic Hydrocarbons: Implications for Developmental, Molecular, and Behavioral Neurotoxicity; 20. Thallium; 21. Arsenicals: Toxicity, Their Use as Chemical Warfare Agents, and Possible Remedial Measures; 22. Chlorine; 23. Phosgene; 24. Carbon Monoxide: Can’t See, Can’t Smell, Body Looks Red But They Are Dead; 25. Acute Cyanide Toxicity and its Treatment: The Body is Dead and Maybe Red but Does Not Stay Red for Long; 26. Methyl Isocyanate: The Bhopal Gas; 27. Other Toxic Chemicals as Potential Chemical Warfare Agents; 28. Ricin; 29. Botulinum Toxin; 30. Onchidal and Fasciculins; 31. Cyanobacterial (Blue-Green Algae) Toxins Section III: Target Organ Toxicity 32. Chemical Warfare Agents and the Nervous System; 33. Behavioral Toxicity of Nerve Agents; 34. The Respiratory Toxicity of Chemical Warfare Agents; 35. Cardiovascular System as a Target of Chemical Warfare Agents; 36. Ocular Toxicity of Chemical Warfare Agents; 37. Skeletal Muscle; 38. Dermal Toxicity of Sulfur Mustard; 39. Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents; 40. Liver Toxicity of Chemical Warfare Agents; 41. Renal System; 42. Impact of Chemical Warfare Agents on the Immune System Section IV: Special Topics 43. Health Effects of Nuclear Weapons and Releases of Radioactive Materials; 44. Clinical and Cellular Aspects of Traumatic Brain Injury; 45. Neurological Effects and Mechanisms of Blast Overpressure Injury; 46. Genomics and Proteomics in Brain Complexity in Relation to Chemically-Induced PTSD; 47. Excitotoxicity, Oxidative Stress, and Neuronal Injury; 48. Blood–Brain Barrier Damage and Dysfunction by Chemical Toxicity; 49. The Effects of Organophosphates in the Early Stages of Human Skeletal Muscle Regeneration; 50. Experimental modeling for delayed effects of organophosphates; 51. Alternative Animal Toxicity Testing of Chemical Warfare Agents Section V: Toxicokinetics, Toxicodynamics and Physiologically-Based Pharmacokinetics 52. Toxicokinetic Aspects of Nerve Agents and Vesicants; 53. Toxicokinetics and Toxicodynamics of DFP; 54. Physiologically Based Pharmacokinetic Modeling of Chemical Warfare Agents; 55. Biotransformation of Warfare Nerve Agents Section VI: Analytical Methods, Biosensors and Biomarkers 56. Laboratory Analysis of Chemical Warfare Agents, Adducts, and Metabolites in Biomedical Samples; 57. On-Site Detection of Chemical Warfare Agents; 58. Neuropathy Target Esterase as a Biomarker and Biosensor of Delayed Neuropathic Agents; 59. The crosslinking action of organophosphorus poisons; implications for chronic neurotoxicity; 60. Monitoring of Blood Cholinesterase Activity in Workers Exposed to Nerve Agents Section VII: Risks to Animals and Wildlife 61. Potential Agents That Can Cause Contamination of Animal Feed stuff and Terror; 62. Chemical Warfare Agents and Risks to Animal Health; 63. Threats to Wildlife by Chemical and Warfare Agents Section VIII: Emergency Preparedness, Prophylactic, Therapeutic and Countermeasures 64. Pharmacological Prophylaxis Against Nerve Agent Poisoning: Experimental Studies and Practical Implications; 65. Prophylactic and Therapeutic Measures in Nerve Agents Poisoning; 66. Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling of Countermeasures to Nerve Agents; 67. Research on Medical Countermeasures for Chemical Attacks on Civilians; 68. Pyridinium Oximes in the Treatment of Poisoning with Organophosphorus Compounds; 69. Novel Cholinesterase Reactivators; 70. Paraoxonase (PON1), detoxication of nerve agents, and modulation of their toxicity; 71. The role of carboxylesterases in therapeutic interventions of nerve agent poisoning; 72. Catalytic bioscavengers: the new generation of bioscavenger-based medical countermeasures Section IX: Decontamination and Detoxification 73. Rapid Decontamination of Chemical Warfare Agents from the Skin

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Book SynopsisTable of ContentsPart 1. Product Discovery and Development 1. Overview of Drug Development 2. Overview of the Role of Pathology in Product Discovery and Development 3. Discovery Toxicology and Discovery Pathology 4. Pathology in Nonclinical Drug Safety Assessment 5. Carcinogenicity Assessment Part 2. Product-Specific Practices for Safety Assessment 6. Protein Therapeutics 7. Nucleic Acid Pharmaceutical Agents 8. Gene Therapy and Gene Editing 9. Vaccines 10. Stem Cells and Other Cell Therapies Part 3: Data Interpretation and Communication 11. Biomedical Materials and Devices 12. Safety Assessment of Agricultural and Bulk Chemicals 13. Preparation of the Anatomic Pathology Report for Toxicity Studies 14. Interpretation of Clinical Pathology Results in Nonclinical Toxicity Testing 15. Assigning Adversity to Toxicologic Outcomes 16. Risk Assessment 17. Risk Management and Communication: Building Trust and Credibility with the Public

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Book SynopsisThe contamination of both drinking and recreational water supplies by cyanobacteria is increasingly a cause for concern worldwide. While contamination causes livestock deaths with relative frequency, acute poisoning is rare in humans. However, there is growing apprehension over the possible role of cylindrospermopsins and microcystins in gastrointestinal and liver cancer. Cyanobacterial Toxins of Drinking Water Supplies provides an articulate account of the biology, chemistry, toxicology, and human health implications of cylindrospermopsins and microcystins, and their occurrence in water supplies. It discusses effective methods of prevention, mitigation, and remediation of cyanobacterial blooms in reservoirs. The book presents novel and traditional approaches to water treatment for the elimination of these toxins. Written by a renowned expert who plays an instrumental role in revising the World Health Organization's drinking water guidelines for cyanotoxins, the book uses thTrade Review“This book covers the biology, chemistry, toxicology, and human health implications of cylindro-spermopsins and microcystins, as well as their occurrence in water supplies. Written by an expert in the field, the book discusses effective methods of prevention, mitigation, and remediation of cyanobacterial blooms in reservoirs and presents both new and traditional approaches for treating water to eliminate these toxins. … ” — In Journal of The Awwa, June 2007Table of ContentsIntroduction. Toxic cyanobacteria and their identification. Toxin chemistry and biosynthesis. Cyanobacterial ecology. Cyanobacterial poisoning of livestock and mankind. Cylindrospermopsin toxicity. Microcystin toxicity. Risk and safety from drinking water. Monitoring of reservoirs for toxic cyanobacteria and analysis of nutrients in water. Detection and analysis of cylindrospermopsins and microcystins. Prevention, mitigation and remediation of cyanobacterial blooms in reservoirs. Water treatment. Emerging issues. Index.

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Book SynopsisTable of ContentsPart 1. Toxicologic Pathology in Environment and Food Protection 1. Environmental Toxicologic Pathology and Human Health 2. Food and Toxicologic Pathology 3. Nutrition and Toxicologic Pathology Part 2. Selected Toxicant Classes 21. Herbal Remedies 22. Phycotoxins 23. Mycotoxins 24. Poisonous Plants 25. Animal Toxins 26. Bacterial Toxins 27. Metals 28. Agrochemicals 29. New Frontiers in Endocrine Disruptor Research 30. Nanoparticulate 31. Radiation and Other Physical Agents

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Book SynopsisClarke's Analysis of Drugs and Poisons is the definitive source of analytical data for drugs and poisons.Trade Review"This continues to be an invaluable reference for pharmaceutical scientists, clinical and forensic toxicologists and environmental chemists...Both the number of substances discussed in the monograph section and the depth of information presented are quite impressive." Randall C. Baselt, Ph.D., Journal of Forensic Science, 2011. -- Randall C. Baselt * Journal of Forensic Science *"Pathologists, clinicians, lawyers and students will find the new Clarke engaging, systematic in its approach and daunting in the massive amount of information provided. It is not until you become accustomed with the layout and logical style of the book that one appreciates the thought that has gone into producing this excellent and essential reference. No toxicologist should be without one!" Dimitri Gerostamoulos, TIAFT Bulletin 41(2), 2011. -- Dimitri Gerostamoulos * TIAFT Bulletin *"The work provides a compilation and easy access to analytical data for numerous compounds that can give an overview without the need of an extensive database search. This is especially true for data of older compounds that cannot be easily found elsewhere...the reader is provided with substantial information making the work an incomparable reference book in drug analysis." Gerhard K.E. Scriba, Department of Pharmaceutical Chemistry, University of Jena, Chromatographia, 10 July 2011. -- Gerhard K.E. Scriba * Chromatographia *Table of ContentsVolume one, part one: methodology and analytical techniques - Contains 44 chapters by leading international scientists covering the practice areas and analytical procedures used in toxicology. Volume two, parts two and three: analytical and toxicological data. Contains 2111 drug and poison monographs detailing physical properties, analytical methods, pharmacokinetic data and toxicity data. Part four: Indexes to analytical data. This part contains indexes of analytical data, including all data for colour tests, chromatography, ultraviolet spectrophotometry, infrared spectrometry and mass spectrometry.

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Book SynopsisAcute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models. For each test, applicable U.S. and international guidelines are also presented, and the formulation and selection of vehicles, dosages, and test animals are addressed.

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