Medical specialties, branches of medicine Books
Harvard University Press Social Neuroscience
Book SynopsisHuman beings evolved in the company of others. Mutually reinforcing connections between brains, minds, and societies have profound implications for physical and emotional health. Social Neuroscience offers a comprehensive new framework for studying human brain development and human behavior in their social context.Trade ReviewThis first-class synthesis of the latest research in neurobiology, sociology, and psychiatry/psychology will be of the greatest interest to both pure scientists and practical clinicians. A new field is being born. Don’t miss it! -- Robert Rosenheck, Professor of Psychiatry and of Public Health, Yale School of MedicineA valuable contribution to this new and exciting field, with implications for potentially new solutions to age-old problems of human nature. -- A. Olivera * Choice *
£43.31
John Wiley & Sons Inc Pharmacology of the Critically Ill
Book SynopsisFocuses on the drugs used to treat the illness or injury in intensive care. This book addresses the other issue for those caring for the critically ill - how organ function will affect the drugs used, and how to adapt management accordingly. It includes principles of pharmacology; absorption, transport, and elimination of drugs.Table of ContentsContributors. Preface. Part 1: Basic Pharmacology. Pharmacokinetics and Pharmacodynamics. Drug Action. Renal Failure. Hepatic Failure. Heart Failure. Gut failure. Brain failure. Respitatory Failure. Children. Safe Drug Prescribing in the Critically Ill. Index.
£64.76
John Wiley & Sons Inc Respiratory Support in Intensive Care
Book SynopsisA guide to the methods used to provide respiratory support in the patient with respiratory failure. It outlines the evolution of different techniques, explains the physiological principles, and evaluates their role in clinical practice. It also includes information on the increasing use of non-invasive techniques.Table of ContentsPreface to first edition. Preface to second edition. Conversion factors, respiratory, and abbreviations used in text. 1.Development of techniques of respiratory support. 2.Physiological background to mechanical ventilation. 3.Mechanical basis of respiratory support. 4.Methods of providing respiratory support. 5.Barotrauma: techniques for reducing peak airway pressure. 6.Modern ventilator technology. 7.Respiratory failure: conservative treatment and indications for providing respiratory support. 8.Selection and care of artificial airways. 9.Care of the patient during respiratory support. 10.Modern ventilator technology. Appendix 1: Suppliers of respiratory support equipment. Index
£73.76
John Wiley and Sons Ltd Kleinians Psychoanalysis Inside Out
Book SynopsisA Melanie Klein and her followers caused a revolution in psychology; this is the first book to bring together and describe their pioneering work. A The book is a highly engaging read, combining lively biographical sketches with psychoanalytic theory and patient case studies.Trade Review'This is an astonishing compilation of biographical and professional details about Melanie Klein and nine of her followers. Many are of such recent history that these are uniquely valuable accounts. They give a clear picture of a remarkable group of contemporary psychoanalysts whose influence since the Second World War has been gaining ground steadily within the international psychoanalytic movement and in other academic and professional disciplines. The group is remarkable, and this book is a remarkable celebration of them.' Bob Hinshelwood, Professor of Psychoanalysis and author of Dictionary of Kleinian Thought and Melanie Klein for Beginners 'This book is a celebration of people who have advanced our understanding of the factors that shape our everyday lives. There are many anecdotes about them here that are quite fascinating.' Australian Journal of PsychotherapyTable of ContentsAcknowledgements. Illustrations. Introduction: Inside Out. Chapter 1: Melanie Klein: Discovering Inner Reality. Chapter 2: Susan Isaacs: Children's Phantasies. Chapter 3: Joan Riveriere: Gendered Masquerades. Chapter 4: Adrian Stokes: Ballet and Art. Chapter 5: Herbert Rosenfeld: Schizophrenics and Gangsters. Chapter 6: Wilfred Bion: Individual and Group Analysis. Chapter 7: Esther Bick: Infant Observation. Chapter 8: Frances Tustin: Anorexia and Autism. Chapter 9: Hanna Segal: Symbolism and Psychosis. Chapter 10: Ronald Britton: Exclusions and Elegies. Conclusion: Further Integrations. Notes. Index.
£49.50
John Wiley and Sons Ltd Mental Illness Polity Key Concepts in the Social
Book Synopsis* A concise and sophisticated introduction to the contested concept of Mental Illness . * Brings together a range of insights and interpretations from various disciplines including sociology, psychology, psychiatry and the neurosciences.Trade Review"Accessible yet rich, and consequently as valuable as, if not superior to, the similar texts that have preceded it. It will be of use to both groups of readers, those who are familiar with the material covered in it and those who are not, and is thus well-suited to the needs of a diverse professional audience."Journal of Mental Health"The relabelling of human distress and eccentricity as mental disorder is one of the great social changes of our time. Joan Busfield provides a breathtakingly lucid and remarkably comprehensive analysis of the vast cross-disciplinary terrain of argument about mental disorder and the meaning of the enormous expansion in disorder diagnoses over the past half-century. Busfield brings not only her sociologist's accomplished eye but also her trained clinician's understanding and a deft wielding of conceptual distinctions to the multifaceted debates over the meaning and social impact of mental disorder."Jerome C. Wakefield, Professor of Social Work and Psychiatry, New York University "Busfield has managed to capture in a single volume the breadth and depth of the highly contested and complex concept of mental illness. Original, accessible and engaging, this important book is a must-read."Kathleen Kendall, Senior Lecturer in Medical Education, University of Southampton "Busfield's book provides a valuable overview of the contested nature of mental illness, offering a balanced critique of some of the key debates regarding psychiatric concepts and categories. She cautions against the extension of psychiatric boundaries to include those experiences that are more helpfully understood in their social context, emphasising the contribution of many complex factors to the classification of mental illness. Her book deserves to be read by anyone interested in mental health and illness, including professionals and students."Kate Karban, Senior Lecturer in Social Work, University of BradfordTable of ContentsList of Figures and Tables Introduction 1 Concepts and Classifications 2 Counting Cases 3 Contested Causes 4 Critiques 5 Conceptual Controversies 6 Care, Control and Costs Conclusion References
£45.00
John Wiley & Sons Inc Neural Networks and Artificial Intelligence for
Book SynopsisUsing examples drawn from biomedicine and biomedical engineering, this essential reference book brings you comprehensive coverage of all the major techniques currently available to build computer-assisted decision support systems. You will find practical solutions for biomedicine based on current theory and applications of neural networks, artificial intelligence, and other methods for the development of decision aids, including hybrid systems. Neural Networks and Artificial Intelligence for Biomedical Engineering offers students and scientists of biomedical engineering, biomedical informatics, and medical artificial intelligence a deeper understanding of the powerful techniques now in use with a wide range of biomedical applications. Highlighted topics include: Types of neural networks and neural network algorithms Knowledge representation, knowledge acquisition, and reasoning methodologies Chaotic analysis of biomedical time series Table of ContentsPreface. Acknowledgments. Overview. NEURAL NETWORKS. Foundations of Neural Networks. Classes of Neural Networks. Classification Networks and Learning. Supervised Learning. Unsupervised Learning. Design Issues. Comparative Analysis. Validation and Evaluation. ARTIFICIAL INTELLIGENCE. Foundation of Computer-Assisted Decision Making. Knowledge Representation. Knowledge Acquisition. Reasoning Methodologies. Validation and Evaluation. ALTERNATIVE APPROACHES. Genetic Algorithms. Probabilistic Systems. Fuzzy Systems. Hybrid Systems. HyperMerge, a Hybird Expert System. Future Perspectives. Index. About the Authors.
£163.76
John Wiley and Sons Ltd Clinical and Laboratory Manual of Implant
Book SynopsisDr. Hamid Shafie's Clinical and Laboratory Manual of Implant Overdentures is a ground-breaking guide to this popular and effective treatment modality, which is increasingly seen as the standard of care for the fully edentulous patient.Trade Review“All phases of implant overdenture therapy are covered. The outstanding clinical documentations and illustrations are presented step by step and easy to follow. Dr. Shafie and his contributors provided the clinician and all members of the implant team excellent material that covers all facets of the implant practice and specifically the implant overdenture. This book will serve as a must-have reference, even for the experienced clinicians. This is an outstanding and complete book for implant overdentures.” (Implant Dentistry, September 2008) "Dr Shafie and his contributors provide the clinician and all members of the implant team with excellent material that covers all facets of the implant practice and specifically the implant overdenture. This book will serve as a must-have reference, even for the experienced clinician. The detailed illustrations and supportive clinical documentations are easy to follow and address every step, form initial consultation to final delivery and recall. This is an outstanding and complete book for implant overdentures." (Implant Dentistry) Table of ContentsCONTRIBUTORS, xiii FOREWORD, xv Dennis Tarnow FOREWORD, xvi Zhimon Jacobson INTRODUCTION, 1 Hamid Shafie 1 Patient Preferences Expectations, 3 Hamid Shafie 2 Diagnosis and Treatment Planning, 11 Hamid Shafie 3 Surgical Guide and Diagnostic Stent, 24 Hamid Shafie, Wolfram Stein, and Amir Juzbasic 4 Principles of Attachment Selection, 31 Hamid Shafie 5 Stud Attachments, 37 Hamid Shafie and James Ellison 6 Bar Attachments, 63 Hamid Shafie and James Ellison 7 Spark Erosion, 85 Hamid Shafie, Eduard Eisenmann, and Gunter Rubeling 8 Success with Implant Overdenture, 104 Hamid Shafie 9 Occlusion and Implant-Supported Overdenture, 112 Hamid Shafie and Frank Luaciello 10 Surgical Considerations for Implant Overdenture, 132 Richard Green, George Obeid, Eskow, and Hamid Shafie 11 Straumann Implant System, 153 Hamid Shafie 12 Endopore Dental Implant System, 161 Hamid Shafie 13 Overdenture Implants, 168 Hamid Shafie 14 Loading Approaches for Mandibular Implant Overdentures, 192 Dittmar May, George Romanos, and Hamid Shafie 15 Clinical Applications for the Measurement of Implant Stability Using Osstell Mentor, 206 Hamid Shafie and Neil Meredith 16 Follow Up and Maintenance of the Implant Overdenture, 210 Robert Eskow, Valerie Sternberg Smith and Roy Eskow 17 Core Principles of the Successful Implant Practice, 216 Sean Crabtree, Paul Homoly, Andress Charalabous, Peter Warkentin, and Kornelius Warkentin INDEX, 233
£135.85
John Wiley and Sons Ltd Salivary Diagnostics
Book SynopsisExplains and surveys one of the most exciting areas of oral biology research Demonstrates the clinical relevance and practical application of saliva diagnostics Inter-disciplinary relevance and appeal across industry and academia Written by luminary team headed by one of the world's recognized authorities in the field.Table of ContentsContributors viii Foreword xv Preface xvii Acknowledgment xviii I Background and Foundation 1 Salivary Gland Development and Regeneration 3 Sarah M. Knox and Matthew P. Hoffman 2 Salivary Gland Physiology Relevant to Diagnostics 14 Victor G. Romanenko and James E. Melvin 3 Saliva: Properties and Functions 27 Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink 4 Saliva Collectors 37 Arjan Vissink, Andy Wolff, and Enno C.I. Veerman 5 Salivary Secretion in Health and Disease 60 Michael D. Turner and Jonathan A. Ship 6 Processing and Storage of Saliva Samples 69 Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw Amerongen II Saliva Diagnostics 7 Historical Perspectives and Present 79 Frank G. Oppenheim 8 Diagnostics Other Than Blood 94 Sudhir Srivastava and Karl Krueger 9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104 Sreenivas Koka and David T. Wong 10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111 Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt 11 Human Salivary Proteomics 122 Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo 12 Genomic Targets in Saliva 129 Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong 13 Point-of-Care Diagnostics for Infectious diseases 136 Paul L.A.M. Corstjens, Daniel Malamud 14 Dental Caries Risk Assessment 150 Paul C. Denny and Patricia A. Denny 15 Periodontal Disease 156 Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile 16 Role of Saliva in Detection of Substance Abuse 169 Uttam Garg and Lance Presley 17 Head and Neck Cancer 180 Joseph A. Califano and Suhail K. Mithani 18 Sjogren's Syndrome 189 Philip C. Fox 19 Salivary Gland Dysfunction Associated with Systemic Disease 198 Nelson L. Rhodus 20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214 Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink 21 The Uses of Saliva in Forensic Genetics 226 Jack Ballantyne and Jane Juusola 22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233 Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. Wong III Saliva Diagnostics—A New Industry 23 Commercialization of Oral Fluid Products and Technologies 243 R. Sam Niedbala 24 Coverage and Reimbursement for Salivary Diagnostic Tests 255 James J. Crall 25 Saliva Diagnostics in the Dentist's and Physician's Office 263 Chakwan Siew and Milton V. Marshall 26 Salivary Hormones in Research and Diagnostics 270 Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel 27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278 Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng 28 Saliva Diagnostics—A New Industry 288 Stuart R. Smith, David T. Wong, and R. Michael Buch Index 295
£160.16
Wiley Dry Mouth The Malevolent Symptom
Book SynopsisXerostomia, more commonly called dry mouth, affects an estimated20 percentof adults worldwide and can severely diminish one's quality of life. Dry Mouth, the Malevolent Symptom: A Clinical Guide relies on evidence-based research to provide an introductory primer on oral dryness and the modalities available to treat it.The book describes the varied etiology of the disease, butemphasizes clinical protocols and step-by-step procedures for diagnosis and treatment planning. Dry Mouth is a user-friendly manual guiding clinicians through identifying and managing this common condition.Causes including radiotherapy, chemotherapy,systemic diseases, polypharmacy, and the natural progression of aging are discussed in conjunction with the clinical symptoms and signs associated with each one. Multiple avenues for treatment are presented, highlighting salivary stimulation and supplementation techniques, pharmacologic aids, and critically required oral therapy. Although intended primTrade Review"Specialists in oral medicine, other hospital-based specialists and anyone with an interest in research into salivary gland function would also find this book a worthwhile addition to their bookshelves." (Primary Dental Care and Team in Practice, 1 April 2011) "This condition can be difficult to manage, and this book makes it clear where more research is warranted... For students this is a must; for clinicians it is a great reference and some of the charts would be useful to have in the surgery." (Team in Practice, October 2010)Table of ContentsPreface. Acknowledgments. Introduction (Olav Alvares) In memoriam: Jonathan Ship (1959–2008)—a celebration of his life Editors and contributors 1. The enigma of dry mouth. 1.1 Dry mouth: a common worldwide tormentor (L.M. Sreebny). 1.2 Saliva: the remarkable fluid (A. van Nieuw Amerongen, E.C.I. Veerman and A. Vissink). 1.3 Living with the drought: the patient speaks (K. Morland Hammitt). 2. Dry mouth: a multifaceted diagnostic dilemma. 2.1 The odd couple: dry mouth and salivary flow (L.M. Sreebny). 2.2 Symptoms and semiotics (A. Vissink and L.M. Sreebny). 2.3 Sialometry: the measure of things, with ease and reliability (L.M. Sreebny and A. Visink). 2.4 Other ways to assess salivary gland disease (A. Vissink). 3. The causes of dry mouth: a broad panoply. 3.1 Drugs, dry mouth and dentistry (L.M. Sreebny). 3.1.1. Setting the stage. 3.1.2. Drugs and the salivary system. 3.1.3. Xerogenic drugs. 3.1.4. Detailed reference guide to drugs and dry mouth. 3.2 Dry Mouth: diseases and conditions. 3.2.1 The auto-immune connection (C.G.M. Kallenberg). 3.2.2 Head and neck radiotherapy: an iatrogenic factor (A. Eisbruch). 3.2.3 Brains and saliva (E.C.I. Veerman and J.A. Bosch). 3.2.4 Other causes of dry mouth: the list is endless (S. Beier Jensen, A.M. Lynge Pedersen and B. Nauntofte). 4. Treating dry mouth: help is available (J. Ship, A. Vissink and L.M. Sreebny). 5. And what about the future? 5.1 Is gene therapy the answer? (B.J. Baum, C. Zheng, L. McCullagh, A.P. Cotrim, J.S. Brahim, J.C. Atkinson, C.M. Goldsmith, N.P. Nikolov, R.J. Turner and G.G. Illei). 5.2 Is stem cell therapy a reasonable approach? (R.P. Coppes and I. Lombaert). 7. Index.
£71.96
John Wiley and Sons Ltd Health Behavior Change in the Dental Practice
Book SynopsisHealth Behavior Change in the Dental Practice presents an overview of health behavior change, focusing on the spirit of motivational interviewing. Targeting the clinical application of the principles, the book applies lessons learned from the field of general and behavioral medicine to the dental practice.Table of ContentsForeword Preface List of Contributors 1. Introduction to Health Behavior Change for the Dental Practice Health Care in the Twenty-first Century The Opportunity in the Dental Setting Adop tion and Integration of Health Behavior Change The Role and Responsibility of the Dental Professional Collaborative Care Toward Whole Health References 2. The Challenge of Behavior Change Introduction Behavior Change: Some Key Concepts The Patient’s Perspective The Clinician’s Perspective Understanding Health Behavior Change Social Cognitive Theory and Self-Efficacy Theory The Health Belief Model Theory of Planned Behavior The Transtheoretical Model of Behavior Change Self-Determination Theory Summary References 3. Communication and Health Behavior Change Counselling Introduction The Relationship between the Clinician and the Patient Styles of Communication Directing Following Guiding Key Skills for Communicating about Health Behavior Change Question 1: Is the patient happy to talk with you about behavior change? Question 2: How are you asking questions? Question 3: How do you provide support? Question 4: How do you convey understanding? Question 5: How do you get information across? Question 6: How do you bring it all together? Summary Acknowledgments References 4. Motivational Interviewing (MI) and Its Basic Tools Introduction What Is Motivational Interviewing? Research Evidence for MI What Triggers Behavior Change? Motivation and the Clinician-Patient Relationship Definition of MI “Spirit” of MI Major Principles Express Empathy Develop Discrepancy Roll with Resistance Support Self-Efficacy OARS: Basic Tools for Building Motivation to Change Use Open-Ended Questions Affirm Patients Use Reflective Listening Use Summaries Elicit Change Talk Evocative Questions Decisional Balance or Pros and Cons Matrix The Importance Ruler Elaborating, Querying Extremes, and Looking Back and Forward Exploring Goals and Values Responding to Change Talk Responding to Resistance Enhancing Confidence Strengthening Commitment Negotiating a Plan for Change Summary References 5. Brief Interventions in Promoting Health Behavior Change Introduction Using a Patient-Centered Approach Righting Reflex Goals of Brief Interventions Assessing Motives Health History Form Open-Ended Questions Readiness Scales Raising Awareness Giving Information versus Raising Awareness Conveying Understanding Supporting Change Encouraging Patient Problem Solving Offering a Set of Strategies Planning for the Change Use of the Telephone for Brief Interventions Use of Computers for Brief Interventions Giving Brief Advice When Brief Interventions Are Not Appropriate Bringing It All Together Summary References 6. Implementation of Health Behavior Change Principles in Dental Practice Introduction Content of Change (the Objectives) Context of Change (the Environment) Process of Change (the Implementation Plan) Micro-Environment: The Dental Visit Easier than You Think Patient Activation Fabric for the Dental Visit (Implementation Model) “Your Patient Is Here,” Single Behavior Patient Scenario Multiple Behavior Patient Scenario Macro-Environment: The Practice Setting Importance of Support Overcoming Potential Obstacles to Practice Implementation Practical Guidance for Beginners (or Non-Beginners) Summary References 7. Health Behavior Change Education Introduction History of Medical and Dental Education In Medicine In Dentistry In Dental Hygiene Currents Trends in Dental Care and Education The Need for Change in Dental Education Public Health Goals and Responsibilities New Educational Initiatives and Methods Theoretical Education Pathology and Epidemiology of Diseases Behavior as a Determinant of Health and Disease Practical Education Students Continuing Education Clinicians Assessment of Health Behavior Change Education Faculty Students Clinicians Summary References Index
£46.76
John Wiley and Sons Ltd Implant Site Development
Book Synopsis* Addresses implant site development and related treatment planning in a logical, practical and easy-to-digest manner * Surveys the whole gamut of site development techniques * Unique integrated clinical approach * Presents a sound and thorough review of evidence .Trade Review“This book introduces and makes clear these recent innovations to all clinicians.” (British Dental Association News, 1 December 2012”Table of ContentsContributors Foreword Acknowledgments 1 Principles of bone biology and regeneration William V. Giannobile and Hector F. Rios 2 Bone anatomy George A. Mandelaris and Alan L. Rosenfeld 3 Treatment philosophy Debby Hwang and Michael Sonick 4 Decision-making algorithm for regeneration of the periodontally compromised tooth: maintaining these teeth when dental implants provide a compelling alternative treatment option Paul S. Rosen and Stuart J. Froum 5 The making of beautiful smiles in perio-implantology André P. Saadoun 6 CT/CBCT diagnosis and treatment planning concepts for bone grafting applications Scott D. Ganz 7 Implant site development: socket preservation Jack T. Krauser and Avi Schetritt 8 Implant interactions in orthodontics Frank Celenza 9 Guided bone regeneration: Concepts and materials Debby Hwang and Michael Sonick 10 Implant site preparation: Horizontal ridge augmentation using particulate allograft and the principles of GBR Michael Sonick and Debby Hwang 11 Guided bone regeneration: Peri-implantation Debby Hwang and Michael Sonick 12 Guided bone regeneration: Vertical growth Istvan Urban 13 Intraoral bone grafts for dental implants Craig M. Misch 14 Bone grafting in large bone defects and extreme atrophy situations Nardy Casap and Yuval Samuni 15 Sinus elevation: Osteotome-mediated approach Michael Toffler 16 Sinus elevation: Lateral wall approach Tomaso Vercellotti 17 Distraction osteogenesis Michael S. Block and Christopher Haggerty 18 Immediate implant placement: A comprehensive understanding for achieving optimal clinical success Robert A. Faiella 19 Soft tissue augmentation: Pre-, peri-, and postimplantation Stefan Fickl and Markus B. Hürzeler 20 Soft tissue enhancement after implant placement Christian F.J. Stappert and Davide Romeo 21 Soft tissue augmentation: allograft Peter C. Shatz and Lee H. Silverstein 22 Soft tissue development with provisional and definitive implant restorations George Priest 23 Bioengineering concepts Eduardo Anitua and Gorka Orive Index
£161.06
Seagull Books London Ltd Conversations with Jacqueline Rose
Book SynopsisIn this collection of conversations that were conducted in Calcutta, at the London School of Economics, through Jewish Book Week, and on the radical website openDemocracy, internationally renowned Jewish scholar Jacqueline Rose explores the debates that have fueled her writing and thinking over three decades. Drawn out by her interlocutors, Rose discusses the difference between political and sexual identity and inquires whether psychoanalysis can be considered a radical form of thought that can be used fruitfully in dialogue about political struggle. Most significantlysince each of these conversations were sparked by her recent and controversial writing on Zionism, Israel, and PalestineRose reflects on the role of Jewish dissent in our time. In these conversations, Rose appears courageous, passionate, ethical, and never afraid to engage politically on issues that are of human concern in the ongoing Middle and Near East crisis.
£10.99
Wiley Manual of Nail Disease and Surgery
Book SynopsisIntended as a practical guide to the treatment of nail problems through medical and surgical means, this book is aimed at the general practitioner, dermatologist and podiatrist. The emphasis throughout is on practical procedures which are in the main relatively simple.Table of ContentsPreface;. 1. Anatomy and Physiology of the Nail Apparatus;. 2. Nail Unit Infections;. 3. Nail Signs and Systemic Disease;. 4. The Nail in Dermatological Diseases;. 5. Occupational Nail Disorders;. 6. Nail Cosmetology;. 7. Nail Unit Tumours and Surgery;. Index
£125.06
John Wiley and Sons Ltd SelfAssessment for Mrcp Part 1
Book SynopsisThe new MRCP Part 1 Paediatrics is a major development in the training of pediatricians. This book is comprised of 350 entirely new questions and indepth explanations. A major feature of the book is a 60 question test designed to be used as practice for the real examination. Both authors participate in teaching pediatricians in training.Table of ContentsIntroduction;. Basic and Clinical Sciences;. Cardiology;. Dermatology;. ENT and Ophthalmology;. Gastroenterology and Nutrition;. Genetics;. Growth and Endocrinology;. Haematology and Oncology;. Immunology and Infections;. Metabolic Disorders;. Neonatology;. Neurology;. Psychiatry and Social Medicine;. Renal Medicine;. Respiratory Medicne;. Surgery;. Therapeutics;. Test Paper;. Bibliography;. Index
£44.60
John Wiley and Sons Ltd Science and Medicine in Sport
Book SynopsisIncludes both sports science and medicine, providing applied information for medical practitioners and other allied health professional, as well as postgraduate students. This book covers both the prevention and treatment of injury, with cross-referenced sections on sports science and sports medicine.Table of ContentsEditors. List of Authors. Special Contributors. Preface to First Edition. Preface to Second Edition. Acknowledgement. Section 1: The Anatomy and Biomechanics of Sport Performance. Applied Anatomy (T. R. Ackland, J. Bloomfield). Biomechanical Principles (B. C. Elliott, G. A. Wood). Biomechanical Analysis (R. N. Marshall, B. C. Elliott). Section 2: Physiology and Nutrition Applied to Sport. Physiology of Training (A. G. Hahn). Nutrition and Energy Sources (V. Deakin, J. R. Brotherhood). Environmental Stress (F. S. Pyke, J. R. Sutton). Section 3: Sport Psychology and Performance Enhancement. Self-regulation and Goal Setting (A. M. D. Gordon). The Individual Athlete (J. W. Bond). Team Athletes (B. P. Miller). The Psychological Aspects of Injury in Sport (J. R. Grove, A. M. D. Gordon). Talent Identification and Profiling (J. Bloomfield). Section 4: Sports Medicine. Classification of Injuries and Mechanisms of Injury, Repair, Healing and Soft Tissue Remodelling (B. W. Oakes). Principles of Treatment and Rehabilitation (C. R. Purdam, P. A. Fricker, B. Cooper). Imaging in Sports Medicine (I. F. Anderson, J. A. Booth). Injuries to the Head, Eye and Ear (A. P. Garnham). Dental Problems (J. P. Fricker, M. L. O’Neill). Injuries to the Spine (K. F. Maguire). Injuries to the Chest and Abdomen (W. Johnson). Injuries to the Shoulder Girdle and Upper Limb (P. A. Fricker, G. Hoy). Injuries to the Pelvis and Lower Limb (K. J. Crichton, P. A. Fricker, C. Purdam, A. S. Watson). Section 5: Special Considerations in Sports Medicine. The Team Physician (B. G. Sando). Children in Sport (A. S. Watson). The Female Athlete (R. J. Carbon). The Disabled Athlete (K. E. Fallon). Medical Considerations in Aquatic Sports (J. J. Kellett). Doping (K. D. Fitch, S. P. Haynes). Exercise and Immunity (D. B. Pyne, A. B. Gray, W. A. McDonald). Special Medical Considerations. Part I. Asthma (A. R. Morton). Part II. Epilepsy (R. A. Reid). Part III. Diabetes Mellitus (D. J. Chisholm). Part IV. Podiatry (A. S. Watson). Part V. Exercise Stress Testing (B. E. F. Hockings). Part VI. Eating Disorders (P. N. Gilchrist, L. Burke). Appendix 1: Orchard Sports Injury Classification System (J. Orchard). Index
£85.45
John Wiley and Sons Ltd Noninvasive Positive Pressure Ventilation
Book SynopsisNoninvasive Positive Pressure Ventilation offers practical, evidence-based advice from experienced authors on the selection of appropriate patients, equipment and techniques used in the initiation of noninvasive positive pressure ventilation (NPPV). It discusses how to anticipate and resolve possible problem scenarios, and how to implement and monitor NPPV programs both in hospitals and in the patient''''s home. Defined as ventilatory assistance given without the need for an invasive airway, NPPV is often preferred over invasive mechanical ventilation because it is more convenient to use, more comfortable for the patient, and avoids complications of invasive mechanical ventilation including upper airway trauma, nosocomial pneumonias, sinusitis and sepsis. However, recipients of NPPV must be carefully selected and considerable skill and experience are necessary for successful implementation. This book aims to provide readers with knowledge that will contribute to that success. Table of ContentsContributors. Foreword (Anita K. Simonds, M.D.). Introduction. 1. Equipment Used for Noninvasive Positive Pressure Ventilation (Dean Hess, Ph.D., R.R.T.). 2. Initiation of Noninvasive Positive Pressure Ventilation (Nicholas S. Hill, M.D., Dean Hess, Ph.D., R.R.T.). 3. Management and Monitoring of Noninvasive Positive Pressure Ventilation (Peter C. Gay, M.D., Nicholas S. Hill, M.D.). 4. Noninvasive Mechanical Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (Nicolino Ambrosino, M.D., Michele Vitacca, M.D.). 5. Noninvasive Positive Pressure Ventilation for Non Chronic Obstructive Pulmonary Disease Causes of Acute Respiratory Failure (Nicholas S. Hill, M.D.). 6. Other Applications of Noninvasive Positive Pressure Ventilation in the Acute Care Setting (Nicholas S. Hill, M.D.). 7. Nasal Positive Pressure Ventilation in Restrictive Thoracic and Central Hypoventilatory Disorders (Patrick Leger, M.D., Nicholas S. Hill, M.D.). 8. Noninvasive Ventilation in Severe Stable Chronic Obstructive Pulmonary Disease (Mark W. Elliott, M.D., Nicholas S. Hill, M.D.). 9. Application of Noninvasive Positive Pressure Ventilation in Children (W. Gerald Teague, M.D., David M. Lang, M.D.). 10. Problems, Remedies, and Strategies to Optimize the Success of Noninvasive Ventilation (Nicholas S. Hill, M.D.). 11. Program Development, Costs, Resource Utilization, and Outcomes Assessment for Noninvasive Ventilation (DeLynn Johnston, B.S., R.R.T., Nicholas S. Hill, M.D.). Appendix. Index.
£99.86
John Wiley and Sons Ltd Birth Asphyxia and the Brain
Book SynopsisThis text presents a state-of-the-art review of asphyxial brain injury to the foetus and new born, a leading source of both neonatal mortality and long-term neurologic disability. Beginning with an historical overview of birth-related injury, followed by an epidemiologic review of the relationship of birth injury to later neuromotor disability, it provides a detailed analysis and exhaustive review of each aspect. The contributors are among the most knowledgeable international authorities in the field; they have synthesized a uniformity of medical and scientific quality, clarity of style, and thoroughness of scope. Continual emphasis is placed on the material''s relevance and usefulness to clinicians; equally important is the emphasis on communication between clinicians and basic neuroscientists. The task of paediatricians and neonatologists in coming years will be to better understand the mechanism of brain damage, the prediction of disability, and the introduction of efficacious neTable of ContentsForeword. Harvey B. Sarnat. Part I. History and Epidemiology. Chapter 1. Cerebral Palsy and Its Causes: Historical Perspectives. Tonse N.K. Raju. Chapter 2. The Relationship of Birth Asphyxia to Later Motor Disability. Michael P. Collins, Nigel S. Paneth. . Part II. Basic Science. . Chapter 3. The Biochemical Neurotoxic Cascade in Hypoxic-Ischemic Injury. Michael V. Johnston, Akira Ishida, Wako Nakajima, William Trescher. Chapter 4. Inflammation and Neonatal Brain Injury. John D.E. Barks, Faye S. Silverstein. Chapter 5. Glucose, Acidosis, and the Developing Brain. Robert C. Vannucci, Susan J. Vannucci. Chapter 6. Energy Consequences of Cerebral Hypoxia-Ischemia. John S. Wyatt. Chapter 7. Apoptosis and Necrosis in Perinatal Brain Injury. Huseyin Mehmet, A. David Edwards. Chapter 8. Effects of Nitric Oxide on Neuronal and Cerebrovascular Function. Donna M. Ferriero, Stephen Ashwal. Chapter 9. Free Radical-Mediated Processes. Ola Didrik Saugstad. . Part III. Clinical Implications. Chapter 10. Antepartum Hypoxemia and the Developing Fetus. Donald M. Peebles, Mark A. Hanson. Chapter 11. Intrapartum Hypoxic-Ischemic Brain Injury. Jenny A. Westgate, Laura Bennet, Alistair J. Gunn. Chapter 12. Clinical Management of the Asphyxiated Newborn. Malcolm Levene, Sunil K. Sinha. Chapter 13. Neuroimaging of Hypoxic-Ischemic Encephalopathy. Mary Rutherford. Chapter 14. Thermal Influence on the Asphyxiated Newborn. Marianne Thoresen. . Part IV Medico-Legal Aspects. Chapter 15. Medico-Legal Implications of Hypoxic-Ischemic Brain Injury. Steven M. Donn, Malcolm L. Chiswick, Paula Whittell, Susan Anderson.
£143.95
Wiley Interactions of Blood and the Pulmonary Circulations
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£100.76
John Wiley & Sons Inc Doppler Radar Physiological Sensing
Book SynopsisPresents a comprehensive description of the theory and practical implementation of Doppler radar-based physiological monitoring This book includes an overview of current physiological monitoring techniques and explains the fundamental technology used in remote non-contact monitoring methods.Table of ContentsList of Contributors xi 1 Introduction 1Amy D. Droitcour, Olga Boric-Lubecke, Shuhei Yamada, and Victor M. Lubecke 1.1 Current Methods of Physiological Monitoring, 2 1.2 Need for Noncontact Physiological Monitoring, 3 1.2.1 Patients with Compromised Skin, 3 1.2.2 Sleep Monitoring, 4 1.2.3 Elderly Monitoring, 5 1.3 Doppler Radar Potential for Physiological Monitoring, 5 1.3.1 Principle of Operation and Power Budget, 6 1.3.2 History of Doppler Radar in Physiological Monitoring, 8 References, 16 2 Radar Principles 21Ehsan Yavari, Olga Boric-Lubecke, and Shuhei Yamada 2.1 Brief History of Radar, 21 2.2 Radar Principle of Operation, 22 2.2.1 Electromagnetic Wave Propagation and Reflection, 23 2.2.2 Radar Cross Section, 24 2.2.3 Radar Equation, 25 2.3 Doppler Radar, 28 2.3.1 Doppler Effect, 28 2.3.2 Doppler Radar Waveforms: CW, FMCW, Pulsed, 29 2.4 Monostatic and Bistatic Radar, 32 2.5 Radar Applications, 35 References, 36 3 Physiological Motion and Measurement 39Amy D. Droitcour and Olga Boric-Lubecke 3.1 Respiratory System Motion, 39 3.1.1 Introduction to the Respiratory System, 39 3.1.2 Respiratory Motion, 40 3.1.3 Chest Wall Motion Associated with Breathing, 43 3.1.4 Breathing Patterns in Disease and Disorder, 43 3.2 Heart System Motion, 44 3.2.1 Location and Gross Anatomy of the Heart, 45 3.2.2 Electrical and Mechanical Events of the Heart, 46 3.2.3 Chest Surface Motion Due to Heart Function, 48 3.2.4 Quantitative Measurement of Chest Wall Motion Due to Heartbeat, 50 3.3 Circulatory System Motion, 53 3.3.1 Location and Structure of the Major Arteries and Veins, 54 3.3.2 Blood Flow Through Arteries and Veins, 55 3.3.3 Surface Motion from Blood Flow, 56 3.3.4 Circulatory System Motion: Variation with Age, 57 3.4 Interaction of Respiratory, Heart, and Circulatory Motion at the Skin Surface, 58 3.5 Measurement of Heart and Respiratory Surface Motion, 58 3.5.1 Radar Measurement of Physiological Motion, 59 3.5.2 Surface Motion Measurement of Respiration Rate, 59 3.5.3 Surface Motion Measurement of Heart/Pulse Rate, 61 References, 63 4 Physiological Doppler Radar Overview 69Aditya Singh, Byung-Kwon Park, Olga Boric-Lubecke, Isar Mostafanezhad, and Victor M. Lubecke 4.1 RF Front End, 70 4.1.1 Quadrature Receiver, 73 4.1.2 Phase Coherence and Range Correlation, 77 4.1.3 Frequency Choice, 79 4.1.4 Antenna Considerations, 80 4.1.5 Power Budget, 80 4.2 Baseband Module, 83 4.2.1 Analog Signal Conditioning and Coupling Methods, 83 4.2.2 Data Acquisition, 85 4.3 Signal Processing, 86 4.3.1 Phase Demodulation, 86 4.3.2 Demodulated Phase Processing, 87 4.4 Noise Sources, 90 4.4.1 Electrical Noise, 90 4.4.2 Mechanical Noise, 92 4.5 Conclusions, 92 References, 93 5 CW Homodyne Transceiver Challenges 95Aditya Singh, Alex Vergara, Amy D. Droitcour, Byung-Kwon Park, Olga Boric-Lubecke, Shuhei Yamada, and Victor M. Lubecke 5.1 RF Front End, 95 5.1.1 Single-Channel Limitations, 96 5.1.2 LO Leakage Cancellation, 103 5.1.3 IQ Imbalance Assessment, 109 5.2 Baseband Module, 113 5.2.1 AC and DC Coupling, 113 5.2.2 DC Canceller, 114 5.3 Signal Demodulation, 118 5.3.1 DC Offset and DC Information, 118 5.3.2 Center Tracking, 125 5.3.3 DC Cancellation Results, 130 References, 134 6 Sources of Noise and Signal-to-Noise Ratio 137Amy D. Droitcour, Olga Boric-Lubecke, and Shuhei Yamada 6.1 Signal Power, Radar Equation, and Radar Cross Section, 138 6.1.1 Radar Equation, 138 6.1.2 Radar Cross Section, 140 6.1.3 Reflection and Absorption, 141 6.1.4 Phase-to-Amplitude Conversion, 141 6.2 Oscillator Phase Noise, Range Correlation and Residual Phase Noise, 143 6.2.1 Oscillator Phase Noise, 143 6.2.2 Range Correlation and Residual Phase Noise, 147 6.3 Contributions of Various Noise Sources, 151 6.3.1 Phase Noise, 151 6.3.2 Baseband 1/f Noise, 154 6.3.3 RF Additive White Gaussian Noise, 154 6.4 Signal-to-Noise Ratio, 155 6.5 Validation of Range Correlation, 157 6.6 Human Testing Validation, 158 References, 168 7 Doppler Radar Physiological Assessments 171John Kiriazi, Olga Boric-Lubecke, Shuhei Yamada, Victor M. Lubecke, and Wansuree Massagram 7.1 Actigraphy, 172 7.2 Respiratory Rate, 176 7.3 Tidal Volume, 179 7.4 Heart Rates, 184 7.5 Heart Rate Variability, 185 7.6 Respiratory Sinus Arrhythmia, 190 7.7 RCs and Subject Orientation, 196 References, 204 8 Advanced Performance Architectures 207Aditya Singh, Aly Fathy, Isar Mostafanezhad, Jenshan Lin, Olga Boric-Lubecke, Shuhei Yamada, Victor M. Lubecke, and Yazhou Wang 8.1 DC Offset and Spectrum Folding, 208 8.1.1 Single-Channel Homodyne System with Phase Tuning, 208 8.1.2 Heterodyne System with Frequency Tuning, 213 8.1.3 Low-IF Architecture, 220 8.2 Motion Interference Suppression, 224 8.2.1 Interference Cancellation, 226 8.2.2 Bistatic Radar: Sensor Nodes, 231 8.2.3 Passive RF Tags, 240 8.3 Range Detection, 250 8.3.1 Physiological Monitoring with FMCW Radar, 250 8.3.2 Physiological Monitoring with UWB Radar, 251 References, 266 9 Applications and Future Research 269Aditya Singh and Victor M. Lubecke 9.1 Commercial Development, 269 9.1.1 Healthcare, 269 9.1.2 Defense, 272 9.2 Recent Research Areas, 272 9.2.1 Sleep Study, 272 9.2.2 Range, 275 9.2.3 Multiple Subject Detection, 276 9.2.4 Animal Monitoring, 279 9.3 Conclusion, 282 References, 282 Index 285
£109.76
John Wiley & Sons Inc Biomedical Materials and Diagnostic Devices
Book SynopsisThe functional materials with the most promising outlook have the ability to precisely adjust the biological phenomenon in a controlled mode.Table of ContentsPreface xv Part I: Biomedical Materials 1. Application of the Collagen as Biomaterials 3 Kwangwoo Nam and Akio Kishida 1.1 Introduction 3 1.2 Structural Aspect of Native Tissue 5 1.3 Processing of Collagen Matrix 8 1.4 Conclusions and Future Perspectives 14 2. Biological and Medical Significance of Nanodimensional and Nanocrystalline Calcium Orthophosphates 19 Sergey V. Dorozhkin 2.1 Introduction 19 2.2 General Information on ?Nano? 21 2.3 Micron- and Submicron-Sized Calcium Orthophosphates versus the Nanodimensional Ones 23 2.4 Nanodimensional and Nanocrystalline Calcium Orthophosphates in Calcified Tissues of Mammals 26 2.5 The Structure of the Nanodimensional and Nanocrystalline Apatites 28 2.6 Synthesis of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 34 2.7 Biomedical Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 47 2.8 Other Applications of the Nanodimensional and Nanocrystalline Calcium Orthophosphates 58 2.9 Summary and Perspectives 58 2.10 Conclusions 61 3. Layer-by-Layer (LbL) Thin Film: From Conventional To Advanced Biomedical and Bioanalytical Applications 101 Wing Cheung MAK 3.1 State-of-the-art LbL Technology 101 3.2 Principle of Biomaterials Based Lbl Architecture 102 3.3 LbL Thin Film for Biomaterials and Biomedical Implantations 103 3.4 LbL Thin Film for Biosensors and Bioassays 105 3.5 LbL Thin Film Architecture on Colloidal Materials 107 3.6 LbL Thin Film for Drug Encapsulation and Delivery 108 3.7 LbL Thin Film Based Micro/Nanoreactor 110 4. Polycaprolactone based Nanobiomaterials 115 Narendra K. Singh and Pralay Maiti 4.1 Introduction 115 4.2 Preparation of Polycaprolactone Nanocomposites 118 4.3 Characterization of Poly(caprolactone) Nanocomposites 119 4.4 Properties 123 4.5 Biocompatibility and Drug Delivery Application 141 4.6 Conclusion 150 Acknowledgement 150 5. Bone Substitute Materials in Trauma and Orthopedic Surgery ? Properties and Use in Clinic 157 Esther M.M. Van Lieshout 5.1 Introduction 158 5.2 Types of Bone Grafts 159 5.3 Bone Substitute Materials 161 5.4 Combinations with Osteogenic and Osteoinductive Materials 171 5.5 Discussion and Conclusion 173 6. Surface Functionalized Hydrogel Nanoparticles 191 Mehrdad Hamidi, Hajar Ashrafi and Amir Azadi 6.1 Hydrogel Nanoparticles 191 6.2 Hydrogel Nanoparticles Based on Chitosan 193 6.3 Hydrogel Nanoparticles Based on Alginate 194 6.4 Hydrogel Nanoparticles Based on Poly(vinyl Alcohol) 195 6.5 Hydrogel Nanoparticles Based on Poly(ethylene Oxide) and Poly(ethyleneimine) 196 6.6 Hydrogel Nanoparticles Based on Poly(vinyl Pyrrolidone) 198 6.7 Hydrogel Nanoparticles Based on Poly-N-Isopropylacrylamide 198 6.8 Smart Hydrogel Nanoparticles 199 6.9 Self-assembled Hydrogel Nanoparticles 200 6.10 Surface Functionalization 201 6.11 Surface Functionalized Hydrogel Nanoparticles 205 Part II: Diagnostic Devices 7. Utility and Potential Application of Nanomaterials in Medicine 215 Ravindra P. Singh, Jeong -Woo Choi, Ashutosh Tiwari and Avinash Chand Pandey 7.1 Introduction 215 7.2 Nanoparticle Coatings 218 7.3 Cyclic Peptides 220 7.4 Dendrimers 221 7.5 Fullerenes/Carbon Nanotubes/Graphene 227 7.6 Functional Drug Carriers 229 7.7 MRI Scanning Nanoparticles 233 7.8 Nanoemulsions 235 7.9 Nanofibers 236 7.10 Nanoshells 239 7.11 Quantum Dots 240 7.12 Nanoimaging 248 7.13 Inorganic Nanoparticles 248 7.14 Conclusion 250 8. Gold Nanoparticle-based Electrochemical Biosensors for Medical Applications 261 Ülkü Anik 8.1 Introduction 261 8.2 Electrochemical Biosensors 262 8.3 Conclusion 272 9. Impedimetric DNA Sensing Employing Nanomaterials 277 Manel del Valle and Alessandra Bonanni 9.1 Introduction 277 9.2 Electrochemical Impedance Spectroscopy for Genosensing 280 9.3 Nanostructured Carbon Used in Impedimetric Genosensors 286 9.4 Nanostructured Gold Used in Impedimetric Genosensors 290 9.5 Quantum Dots for Impedimetric Genosensing 293 9.6 Impedimetric Genosensors for Point-of-Care Diagnosis 293 9.7 Conclusions (Past, Present and Future Perspectives) 294 10. Bionanocomposite Matrices in Electrochemical Biosensors 301 Ashutosh Tiwari, Atul Tiwari 10.1 Introduction 301 10.2 Fabricationof SiO2-CHIT/CNTs Bionanocomposites 303 10.3 Preparation of Bioelectrodes 304 10.4 Characterizations 305 10.5 Electrocatalytic Properties 307 10.6 Photometric Response 315 10.7 Conclusions 316 11. Biosilica? Nanocomposites - Nanobiomaterials for Biomedical Engineering and Sensing Applications 321 Nikos Chaniotakis, Raluca Buiculescu 11.1 Introduction 321 11.2 Silica Polymerization Process 323 11.3 Biocatalytic Formation of Silica 325 11.4 Biosilica Nanotechnology 327 11.5 Applications 328 11.6 Conclusions 334 12. Molecularly Imprinted Nanomaterial-based Highly Sensitive and Selective Medical Devices 337 Bhim Bali Prasad and Mahavir Prasad Tiwari 12.1 Introduction 337 12.2 Molecular Imprinted Polymer Technology 340 12.3 Molecularly Imprinted Nanomaterials 360 12.4 Molecularly Imprinted Nanomaterial-based Sensing Devices 362 12.5 Conclusion 379 13. Immunosensors for Diagnosis of Cardiac Injury 391 Swapneel R. Deshpande, Aswathi Anto Antony, Ashutosh Tiwari, Emilia Wiechec, Ulf Dahlström, Anthony P.F. Turner 13.1 Immunosensor 391 13.2 Myocardial Infarction and Cardiac Biomarkers 392 13.3 Immunosensors for Troponin 399 13.4 Conclusions 404 Part III: Drug Delivery and Therapeutics 14. Ground-Breaking Changes in Mimetic and Novel Nanostructured Composites for Intelligent-, Adaptive- and In vivo-responsive Drug Delivery Therapies 411 Dipak K. Sarker 14. 1 Introduction 411 14.2 Obstacles to the Clinician 420 14.3 Hurdles for the Pharmaceuticist 428 14.4 Nanostructures 431 14.5 Surface Coating 435 14.7 Formulation Conditions and Parameters 439 14.8 Delivery Systems 440 14.9 Evaluation 443 14.10 Conclusions 447 15. Progress of Nanobiomaterials for Theranostic Systems 451 Dipendra Gyawali, Michael Palmer, Richard T. Tran and Jian Yang 15.1 Introduction 451 15.2 Design Concerns for Theranostic Nanosystems 456 15.3 Designing a Smart and Functional Theranostic System 459 15.4 Materials for Theranostic System 462 15.5 Theranostic Systems and Applications 474 15.6 Future Outlook 481 16. Intelligent Drug Delivery Systems for Cancer Therapy 493 Mousa Jafari, Bahram Zargar, M. Soltani, D. Nedra Karunaratne, Brian Ingalls, P. Chen 16.1 Introduction 493 16.2 Peptides for Nucleic Acid and Drug Delivery in Cancer Therapy 494 16.3 Lipid Carriers 499 16.4 Polymeric Carriers 506 16.5 Bactria Mediated Cancer Therapy 514 16.6 Conclusion 519 Part IV: Tissue Engineering and Organ Regeneration 531 17. The Evolution of Abdominal Wall Reconstruction and the Role of Nonobiotecnology in the Development of Intelligent Abdominal Wall Mesh 533 Cherif Boutros, Hany F. Sobhi and Nader Hanna 17.1 The Complex Structure of the Abdominal Wall 534 17.2 Need for Abdominal Wall Reconstruction 535 17.3 Failure of Primary Repair 535 17.4 Limitations of the Synthetic Meshes 536 17.5 Introduction of Biomaterials To Overcome Synthetic Mesh Limitations 537 17.6 Ideal Material for Abdominal Wall Reconstruction 538 17.7 Role of Bionanotechnology in Providing the 17.7 Future Directions 542 18. Poly(Polyol Sebacate)-based Elastomeric Nanobiomaterials for Soft Tissue Engineering 545 Qizhi Chen 18.1 Introduction 545 18.2 Poly(polyol sebacate) Elastomers 547 18.3 Elastomeric Nanocomposites 562 18.4 Summary 569 19. Electrospun Nanomatrix for Tissue Regeneration 577 Debasish Mondal and Ashutosh Tiwari 19.1 Introduction 577 19.2 Electrosun Nanomatrix 578 19.3 Polymeric Nanomatrices for Tissue Engineering 580 19.4 Biocompatibility of the Nanomatrix 581 19.5 Electrospun Nanomatrices for Tissue Engineering 583 19.6 Status and Prognosis 592 20. Conducting Polymer Composites for Tissue Engineering Scaffolds 597 Yashpal Sharma, Ashutosh Tiwari and Hisatoshi Kobayashi 20.1 Introduction 598 20.3 Synthesis of Conducting Polymers 599 20.4 Application of Conducting Polymer in Tissue Engineering 600 20.5 Polypyrrole 600 20.6 Poly(3,4-ethylene dioxythiophene) 602 20.7 Polyaniline 603 20.8 Carbon Nanotube 605 20.9 Future Prospects and Conclusions 607 21. Cell Patterning Technologies for Tissue Engineering 611 Azadeh Seidi and Murugan Ramalingam 21.1 Introduction 611 21.2 Patterned Co-culture Techniques 612 21.3 Applications of Co-cultures in Tissue Engineering 618 21.4 Concluding Remarks 619 Acknowledgements 619 References 620 Index 000
£188.96
John Wiley & Sons Inc Drugdevice Combinations for Chronic Diseases
Book SynopsisThis book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice. The book: Discusses where drugs and devices work, where they fail, and when they need to work with each other Reviews interactions betweenhuman bodies and the drug-device combination productsthe measurements of these interactions Covers how a drug-device combination product is developed, tested, and regulated Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes Table of ContentsFOREWORD vii PREFACE ix PART I BACKGROUNDS 1 1 Addressing Medical Device Challenges with Drug–Device Combinations 3 2 Historical Survey of Drug Delivery Devices 39 3 Development of Combination Product Drug Delivery Systems 66 4 Drug–Material Interactions, Materials Selection, and Manufacturing Methods 89 PART II PRODUCTS 117 5 Steroid-Releasing Lead 119 6 Thromboresistant Vascular Graft 142 7 Device-Enabled Drug Infusion Therapies 182 8 Promus Element Plus®: A Drug-Eluting Stent 214 9 Infuse® Bone Graft 241 INDEX 261
£124.40
John Wiley & Sons Inc Micro and Nanotechnologies in Engineering Stem
Book SynopsisThis book focuses on the latest advances in stem cells and tissue engineering using micro and nanotechnologies.Table of ContentsPreface xiii Contributors xv 1 Stem Cells and Nanotechnology in Tissue Engineering and Regenerative Medicine 1 1.1 A Brief History of Tissue Engineering and Regenerative Medicine, 1 1.2 Introduction to Stem Cells, 3 1.3 Tissue Engineering and Regenerative Medicine Strategies, 5 1.4 Nanotechnology in Regenerative Medicine and Tissue Engineering, 8 1.5 Conclusions, 19 2 Nanofiber Technology for Controlling Stem Cell Functions and Tissue Engineering 27 2.1 Introduction, 27 2.2 Fabrication of Nanofibrous Scaffolds by Electrospinning, 30 2.3 Stem Cells: Type, Origin, and Functionality, 32 2.4 Stem Cell–Nanofiber Interactions in Regenerative Medicine and Tissue Engineering, 35 2.5 Conclusions, 44 3 Micro- and Nanoengineering Approaches to Developing Gradient Biomaterials Suitable for Interface Tissue Engineering 52 3.1 Introduction, 52 3.2 Classification of Gradient Biomaterials, 54 3.3 Micro- and Nanoengineering Techniques for Fabricating Gradient Biomaterials, 59 3.4 Conclusions, 70 4 Microengineered Polymer- and Ceramic-Based Biomaterial Scaffolds: A Topical Review on Design, Processing, and Biocompatibility Properties 80 4.1 Introduction, 80 4.2 Dense Hydroxyapatite Versus Porous Hydroxyapatite Scaffold, 85 4.3 Property Requirement of Porous Scaffold, 86 4.4 Design Criteria and Critical Issues with Porous Scaffolds for Bone Tissue Engineering, 88 4.5 An Exculpation of Porous Scaffolds, 90 4.6 Overview of Various Processing Techniques of Porous Scaffold, 92 4.7 Overview of Physicomechanical Properties Evaluation of Porous Scaffold, 95 4.8 Overview of Biocompatibility Properties: Evaluation of Porous Scaffolds, 104 4.9 Outstanding Issues, 107 4.10 Conclusions, 109 5 Synthetic Enroutes to Engineer Electrospun Scaffolds for Stem Cells and Tissue Regeneration 119 5.1 Introduction, 119 5.2 Synthetic Enroutes, 125 5.3 Novel Nanofibrous Strategies for Stem Cell Regeneration and Differentiation, 131 5.4 Conclusions, 135 6 Integrating Top-Down and Bottom-Up Scaffolding Tissue Engineering Approach for Bone Regeneration 142 6.1 Introduction, 142 6.2 Clinic Needs in Bone Regeneration Fields, 143 6.3 Bone Regeneration Strategies and Techniques, 144 6.4 Future Direction and Concluding Remarks, 151 7 Characterization of the Adhesive Interactions Between Cells and Biomaterials 159 7.1 Introduction, 159 7.2 Adhesion Receptors in Native Tissue, 160 7.3 Optimization of Cellular Adhesion Through Biomaterial Modification, 166 7.4 Measurement of Cell Adhesion, 170 7.5 Conclusions, 174 8 Microfluidic Formation of Cell-Laden Hydrogel Modules for Tissue Engineering 183 8.1 Introduction, 183 8.2 Cell-Laden Hydrogel Modules, 184 8.3 Cell Assay Systems Using Microfluidic Devices, 189 8.4 Implantable Applications, 191 8.5 Tissue Engineering, 194 8.6 Summary, 198 9 Micro- and Nanospheres for Tissue Engineering 202 9.1 Introduction, 202 9.2 Materials Classification of Micro- and Nanospheres, 204 9.3 Applications of Micro- and Nanospheres in Tissue Engineering, 205 9.4 Conclusions, 212 10 Micro- and Nanotechnologies to Engineer Bone Regeneration 220 10.1 Introduction, 220 10.2 Nano-Hydroxyapatite Reinforced Scaffolds, 221 10.3 Biodegradable Polymeric Scaffolds and Nanocomposites, 225 10.4 Silk Fibers and Scaffolds, 227 10.5 Summary, 231 11 Micro- and Nanotechnology for Vascular Tissue Engineering 236 11.1 Introduction, 236 11.2 Conventional Vascular Grafts, 237 11.3 Tissue-Engineered Vascular Grafts, 237 11.4 Micro- and Nanotopography in Vascular Tissue Engineering, 238 11.5 Micro- and Nanofibrous Scaffolds in Vascular Tissue Engineering, 241 11.6 Microvascular Tissue Engineering, 246 11.7 Conclusions, 253 12 Application of Stem Cells in Ischemic Heart Disease 261 12.1 Introduction, 261 12.2 Adult Skeletal Myoblast Cells, 267 12.3 Adult Bone Marrow–Derived Stem Cells, 269 12.4 Type of Stem Cells Used to Treat Cardiac Diseases, 273 12.5 Application, 277 12.6 Other Developing Technologies in Cell Engineering, 282 Acknowledgments, 293 References, 293 Index 303
£125.06
John Wiley & Sons Inc Bio and Multifunctional Polymer Architectures
Book SynopsisThis reference/text addresses concepts and synthetic techniques for the preparation of polymers for state-of-the-art usein biomedicine, synthetic biology, and bionanotechnology.Table of ContentsPreface xi Acknowledgments xiii 1 Introduction 1 1.1 What makes Polymers so Interesting? 1 1.2 Macromolecular Engineering and Nanostructure Formation 4 1.3 Specific Needs in Bionanotechnology and Biomedicine 5 Reference 6 2 Terminology 7 2.1 Polymer Architectures 7 2.2 Multifunctionality 11 2.3 Bioconjugates 12 2.4 Biocompatibility 12 2.5 Biodegradation 14 2.6 Bioactivity 14 2.7 Multivalency 15 2.8 Bionanotechnology 17 References 18 3 Preparation Methods and Tools 19 3.1 General Aspects of Polymer Synthesis 19 3.1.1 Chain Growth Polymerizations 20 3.1.2 Step Growth Polymerizations 23 3.1.3 Modification of Polymers 25 3.2 Controlled Polymer Synthesis 25 3.2.1 Anionic Polymerization 26 3.2.2 Cationic Polymerization 30 3.2.3 Controlled Radical Polymerization 34 3.2.4 Metal‐Catalyzed Polymerization 37 3.2.5 Chain Growth Condensation Polymerization 41 3.3 Effective Polymer Analogous Reactions 43 3.4 Pegylation 47 3.5 Bioconjugation 51 3.5.1 Polynucleotide Conjugates 53 3.5.2 Protein Conjugates 55 3.5.3 Polysaccharide Conjugates 57 3.6 Enzymatic Polymer Synthesis 59 3.7 Solid Phase Synthesis and Biotechnological Approaches 63 3.7.1 Solid Phase Synthesis 63 3.7.2 Biotechnology Approaches in the Synthesis of Biopolymers 75 3.8 Hydrogels and Hydrogel Scaffolds 81 3.8.1 Hydrogels 81 3.8.2 Hydrogels as Scaffold Materials 84 3.9 Surface Modification and Film Preparation 92 3.9.1 Self‐Assembled Monolayers 93 3.9.2 Langmuir–Blodgett Films 95 3.9.3 Layer‐by‐Layer Deposition 96 3.9.4 Immobilization by Chemical Binding to Substrates 97 3.9.5 Low‐Pressure Plasma 99 3.9.6 Electron Beam Treatment 101 3.10 Microengineering of Polymers and Polymeric Surfaces 102 References 107 4 Analytical Methods 113 4.1 Molecular Structure and Molar Mass Determination of Polymers and Biohybrids 113 4.1.1 Structural Characterization 114 4.1.2 Determination of Molar Mass and Molar Mass Distribution 132 4.2 Characterization of Aggregates and Assemblies 137 4.2.1 Dynamic Light Scattering 138 4.2.2 Pulsed Field Gradient and Electrophoretic Nuclear Magnetic Resonance 139 4.2.3 Field‐Flow Fractionation 142 4.2.4 UV–Vis Spectroscopy and Fluorescence Spectroscopy 144 4.2.5 Electron Microscopy 145 4.3 Characterization of Hydrogel Networks 147 4.3.1 Network Structure of Hydrogels 148 4.3.2 Swelling Degree 148 4.3.3 Mechanical Properties 150 4.3.4 Deriving Microscopic Network Parameters from Macroscopic Hydrogel Properties 153 4.4 Surface Characterization 154 4.4.1 X‐Ray Photoelectron Spectroscopy 154 4.4.2 Contact Angle Measurements by Axisymmetric Drop Shape Analysis 157 4.4.3 Electrokinetic Measurements 158 4.4.4 Spectroscopic Ellipsometry 159 4.4.5 Quartz Crystal Microbalance with Dissipation Monitoring 160 4.4.6 Surface Plasmon Resonance 161 4.4.7 Scanning Force Techniques 162 4.4.8 Environmental Scanning Electron Microscopy 164 4.5 Biophysical Characterization and Biocompatibility 166 4.5.1 Biophysical Characterization 167 4.5.2 Biocompatibility 175 References 183 5 Multifunctional Polymer Architectures 187 5.1 Multifunctional (Block) Copolymers 187 5.1.1 Multifunctionality through Copolymerization 187 5.1.2 Multifunctionality by Polymer Analogous Reactions 189 5.1.3 Spatially Defined Multifunctionality by Phase Separation and Self‐Assembly of Segmented Copolymers 190 5.2 Dendritic Polymers 196 5.2.1 Synthesis of Dendrimers and Hyperbranched Polymers 198 5.2.2 Properties and Applications 200 5.3 Glycopolymers 203 5.3.1 Linear Glycopolymers 205 5.3.2 Globular Glycomacromolecules 207 5.4 Peptide‐Based Structures 212 5.4.1 Hierarchical Self‐Assembly of Peptide Molecules 214 5.4.2 General Design Concepts for Peptide‐Based Structural Materials 215 5.4.3 Noncanonical Amino Acids in Peptide/Protein Engineering 217 5.4.4 Peptide‐Based Materials Inspired by Naturally Occurring Structural Proteins 217 5.4.5 Polypeptide Materials Based on other Naturally Occurring or De Novo Designed Self‐Assembling Domains such as Coiled Coils 221 5.4.6 Self‐Assembly of Short Peptide Derivates and Peptide‐Based Amphiphilic Molecules 222 5.5 Biohybrid Hydrogels 224 5.5.1 Composition Basic Principles and Formation of Biohybrids 225 5.5.2 Polynucleotide Biohybrids 228 5.5.3 Polypeptide or Protein Biohybrids 231 5.5.4 Polysaccharide Biohybrids 232 References 235 6 Functional Materials and Applied Systems 241 6.1 Organic Nanoparticles and Aggregates for Drug and Gene Delivery 241 6.1.1 Polymeric Micelles Polymersomes and Nanocapsules 241 6.1.2 Polymeric Beads and Micro/Nanogels Based on Dendritic Structures 254 6.1.3 Polyplexes for Gene Delivery 263 6.2 Polymer Therapeutics and Targeting Approaches 264 6.2.1 Current Status of Polymer Therapeutics 264 6.2.2 Implications and Rationale for Effective Delivery Systems 266 6.2.3 Cellular Uptake and Targeting 267 6.3 Multi‐ and Polyvalent Polymeric Architectures 271 6.3.1 Polyvalent Interactions on Biological Interfaces 272 6.3.2 Prospects for Multivalent Drugs 277 6.4 Bioresponsive Networks 280 6.4.1 Active Principle 280 6.4.2 Homeostatic Regulation of Blood Coagulation 281 6.4.3 Insulin Release in Response to Glucose Concentration 282 6.4.4 Urate‐Responsive Release of Urate Oxidase 283 6.4.5 Cell‐Responsive Degradation of Hydrogel Networks 284 6.5 Biofunctional Surfaces 284 6.5.1 Concepts and Aims of Biofunctional Material Surfaces 284 6.5.2 Biofunctional Surfaces for the Prevention of Biofouling 287 6.5.3 Anticoagulant Coatings for Blood‐Contacting Devices 292 References 295 Abbreviations 303 Index 309
£136.76
John Wiley and Sons Ltd Vascular Imaging of the Central Nervous System
Book SynopsisThe first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decade The last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precisewith computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances. Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologistsespecially neuroradiologistshow to optimize the use of the many techniques available in order to increase the sensitivity and specificity of vascular imaging, thereby improving the diagnosis and treatment of individual patients. Each chapter is formatted carefully and divided into two essential parts: The first part describes the physical principles underlying each imaging technique, along potTable of ContentsList of Contributors, vii Preface, ix Acknowledgments, x Part One Ultrasound Vascular Imaging (UVI), 1 1 Basic Principles of Ultrasound Sonography, 3 Ana Maria Braz, Jaime Leal Pamplona and Joana N. Ramalho 2 Clinical Applications of Ultrasound Vascular Imaging, 14 Ana Maria Braz, Maria Madalena Patricio, and Joana N. Ramalho Clinical Vignette #1 – Occlusive dissection of the proximal primitive carotid artery with extension to the ICA, 29 3 Novel Applications of Ultrasound Vascular Imaging, 33 Elsa Irene Azevedo and Pedro Miguel Castro Clinical Vignette #1 – Indirect signs of carotid dissection, 60 Clinical Vignette #2 – A case of severe perfusion deficit and lack of cerebral vasoreactivity in spite of normal neurologic examination and cranial CT, 61 Part Two Computed Tomography Angiography (CTA), 67 4 Basic Principles of Computed Tomography Angiography (CTA), 69 Margareth Kimura and Mauricio Castillo Clinical Vignette # 1 – Revascularization procedure evaluation by CTA, 81 5 Intracranial Computed Tomography Angiography (CTA), 83 Isabel R. Fragata and Joana N. Ramalho Clinical Vignette #1 – Acute stroke, 105 Clinical Vignette #2 – Acute intracerebral hematoma, 105 6 Extracranial Computed Tomography Angiography (CTA), 110 Tiago Baptista and João Lopes Reis Clinical Vignette #1 – Carotid stenosis, 118 Part Three Magnetic Resonance Vascular Imaging (MRV), 125 7 Basic Principles of Time-of-Flight Magnetic Resonance Angiography (TOF MRA) and MRV, 127 Hugo Alexandre Ferreira and Joana N. Ramalho 8 Basic Principles of Phase Contrast Magnetic Resonance Angiography (PC MRA) and MRV, 137 Hugo Alexandre Ferreira and Joana N. Ramalho 9 Time-of-Flight Magnetic Resonance Angiography (TOF MRA) and MRV: Clinical Applications, 146 Mauricio Castillo, Juan Camilo Márquez, and Francisco José Medina 10 Phase Contrast Magnetic Resonance Angiography (PC MRA) and Flow Analysis: Clinical Applications, 161 Pedro Vilela Clinical Vignette #1 – PC MRA, 171 11 Contrast-Enhanced Magnetic Resonance Angiography (MRA): Fundamentals and Clinical Applications, 176 Khurram Javed and Mauricio Castillo Clinical Vignette #1 – Internal carotid artery stenosis quantifi cation, 183 12 Intracranial Magnetic Resonance Angiography (MRA), 1.5 T versus 3 T: Advantages and Disadvantages, 186 Sara Safder, Benjamin Huang, and Mauricio Castillo Clinical Vignette #1 – Questionable middle cerebral artery stenosis, 192 13 Time-Resolved Techniques, Basic Principles, and Clinical Applications, 194 Nuno Almeida, David Silva Monteiro, and Daniela Seixas Clinical Vignette # 1 – Occipital arteriovenous malformation (AVM), 204 Part Four Digital Subtraction Angiography (DSA), 207 14 Digital Subtraction Angiography (DSA): Basic Principles, 209 Mauricio Castillo Clinical Vignette #1 – Use of DSA in seizure patient, 219 15 Digital Subtraction Angiography (DSA) in Clinical Practice, 221 Yueh Z. Lee and Mauricio Castillo 16 Advanced and Future Digital Subtraction Angiography (DSA) Applications, 229 Pedro Vilela Clinical Vignette #1 – Digital subtraction angiography, 247 Part Five Brain Perfusion Techniques: Computed Tomography (CT) and Magnetic Resonance Imaging (MRI), 255 17 Computed Tomography (CT) Perfusion: Basic Principles and Clinical Applications, 257 Joana N. Ramalho and Isabel R. Fragata Clinical Vignette # 1 – Acute stroke, 272 18 Dynamic Susceptibility Contrast-Enhanced MRI Perfusion: Basic Principles and Clinical Applications, 275 Francisco José Medina, Mauricio Castillo, and Juan Camilo Márquez 19 Arterial Spin Labeling (ASL) Perfusion: Basic Concepts, Artifacts, and Clinical Applications, 294 Debora Bertholdo and Mauricio Castillo Part Six Plaque Imaging, 307 20 Imaging of Carotid Plaque, 309 Sangam G. Kanekar Clinical Vignette #1 – Case examples, 332 Part Seven Intravascular Imaging, 345 21 Basic Concepts and Clinical Applications of Intravascular Imaging, 347 Hideki Kitahara, Peter J. Fitzgerald, Paul G. Yock, and Yasuhiro Honda Clinical Vignette #1 – Right internal carotid artery stenosis and left internal carotid artery occlusion, 368 Part Eight Pediatric Vascular Imaging, 371 22 Pediatric Vascular Imaging Techniques and Clinical Applications, 373 Carla R. Conceição, Rita Lopes da Silva and Joana N. Ramalho Clinical Vignette #1 – Use of CT and MRI in a pediatric patient, 401 Index, 405
£132.26
John Wiley and Sons Ltd Acne
Book SynopsisLearn to accurately diagnose, prevent and treat all three acnes using both traditional and novel approaches to understanding the causes and selecting the most effective treatments. Acne vulgaris is an extremely common condition. It is troublesome to manage, often persisting into middle age.Table of ContentsPreface ix Practical acne therapy xii Genetics xii Diet xii Hormones xii Stress xiii Comedones (plugs in pores) xiii Blemishes—a brief catalogue xiv Nodules xv Scars and sinuses xvi Support xvii Introduction xviii Nomenclature xix The three acnes and grading xx Acne vulgaris xx Acne rosacea xxii Acne inversa (hidradenitis suppurativa) xxiii Grading the three acnes xxvi Acne vulgaris xxvi Acne rosacea xxvi Acne inversa (hidradenitis suppurativa) xxvi 1 The three acnes and their impact 1 1.1 Acne vulgaris 1 1.1.1 Terminology 1 1.1.2 The starting point 3 1.2 Acne rosacea 3 1.2.1 The “pimply” part 4 1.2.2 The “redness” part 4 1.2.3 The third part the firm fibrosis 6 1.2.4 Part four—ocular rosacea 7 1.2.5 Putting it all together 7 1.2.6 The inflammatory epiphenomena in acne rosacea 8 1.2.7 The “acne rosacea” versus “rosacea” controversy 12 1.2.8 Summary 12 1.3 Acne inversa (formerly hidradenitis suppurativa) 12 1.3.1 Before the rupture where and why? 15 1.3.2 After the rupture what next? 15 1.3.3 So what invaders are important in acne inversa? 15 1.3.4 What makes this disease behave so much worse than acne vulgaris? 18 1.3.5 So what can one possibly do to settle down all this inflammation? 21 1.3.6 So how do you get rid of all this material? 25 1.3.7 What does the future offer? 25 1.4 The psychology of acne 26 1.4.1 Acne as a stress 26 1.4.2 Acne and self-image 27 1.4.3 Isotretinoin therapy and the psyche 27 1.4.4 The isotretinoin–depression question 28 1.4.5 Isotretinoin in perspective 29 2 The folliculopilosebaceous unit—the normal FPSU 31 2.1 Anatomy 31 2.2 Genetics 31 2.2.1 Acne vulgaris 31 2.2.2 Acne rosacea 34 2.2.3 Acne inversa/hidradenitis suppurativa (AI/HS) 34 2.2.4 The scottish twins 34 2.3 Epigenetics 35 2.3.1 The farmer’s boys 36 2.4 Embryology 36 2.5 Histology 38 2.5.1 Onwards and downwards 38 2.5.2 What is going on inside the FPSU? 40 2.6 Physiology 42 2.6.1 Hair first 42 2.6.2 Oil second 42 2.6.3 Last but definitely not least: the follicle 43 2.6.4 Looking deeper 44 2.7 Biochemistry 44 2.8 Hormones enzymes receptors and the intracrine system 45 2.8.1 The intracrine system 48 2.9 FoxO1 and mTORC1 49 2.9.1 The next step 50 2.9.2 The broad view 51 3 Pathogenetic mechanisms summarized 54 3.1 Acne vulgaris 54 3.2 Acne rosacea 56 3.3 Acne inversa/hidradenitis suppurativa (AI/HS) 57 3.4 Other variants 60 3.4.1 Malassezia folliculitis 60 3.4.2 Eosinophilic pustular folliculitis (ofuji’s disease) 62 3.4.3 Dissecting terminal folliculitis 63 3.4.4 Acne keloidalis 63 3.4.5 Epidermal growth factor receptor (EGFR) inhibitor eruption 64 3.4.6 Acné excoriée des jeunes filles 65 4 The acne hormones 67 4.1 The endogenous hormones 67 4.1.1 Androgens and their sources 67 4.1.2 Estrogens and their sources 68 4.1.3 Progesterone and the progesteroids 68 4.1.4 Insulin 69 4.1.5 Growth hormone and insulin-like growth factor-1 72 4.2 The exogenous hormones 72 4.2.1 Anabolic steroids 72 4.2.1.1 Mothers’ milk 72 4.2.1.2 Muscle makers 74 4.2.2 Oral contraceptive hormones 74 4.2.2.1 Oral estrogens 74 4.2.2.2 Oral progestins 75 4.2.2.3 Extended cycles 75 4.2.3 Other exogenous birth control hormones 77 4.2.3.1 Implants 77 4.2.3.2 Intrauterine devices 78 4.2.3.3 Intravaginal devices 78 4.2.3.4 Topicals: the patches 78 4.2.3.5 Intramuscular (depot) injections 78 4.2.4 Dietary sources of hormones 78 4.2.4.1 The impact of diet on acne 80 4.2.4.2 Carbohydrate load versus dairy load 83 5 Exogenous acnegens and acneform eruptions 87 5.1 Chemicals and medications 87 5.2 Endocrine imitators and disruptors 87 5.2.1 Environmental contamination 88 5.3 Foods 88 5.3.1 Iodine and bromine 89 5.3.2 Chocolate 89 5.3.3 Casein and whey 90 5.4 Photodamage glycation and the acne and aging processes 91 5.5 Smoking and nicotine 91 6 Follicular flora fauna and fuzz 93 6.1 Propionibacterium acnes (P. acnes) 93 6.1.1 Normal role of P. acnes 94 6.1.2 Pathogenic role of P. acnes 94 6.2 Malassezia species 95 6.2.1 Normal role 95 6.2.2 Immunogenicity 97 6.2.3 Pruritogenicity 98 6.2.4 Malassezia in the acnes 98 6.3 Staph strep and Gram-negative organisms 99 6.4 Demodex 99 6.5 Vellus hairs 101 7 The inflammatory response 103 7.1 Innate immunity 103 7.2 Adaptive (acquired) immunity 104 7.3 Inflammation as the primary acnegen 104 7.4 Mediators cellular and humoral and neuroimmunology 105 7.5 Allergy (shared antigens) 106 7.6 Inflammation pigment and PIH 106 7.7 Inflammation and scarring 107 8 Management 109 8.1 Prevention 109 8.2 General principles of management 111 8.3 Diet 111 8.3.1 Dairy 112 8.3.1.1 The deli-planning heiress 114 8.3.1.2 The pharmaceutical executive 115 8.3.2 Carbohydrates glycemic load and hyperinsulinemia 115 8.3.3 The paleolithic diet 116 8.3.4 High-fructose corn syrup (HFCS) 116 8.3.5 Metformin 116 8.3.6 Synthesis and summary 117 8.4 Comedolytics and other topicals 117 8.4.1 Standard topical comedolytics 118 8.4.1.1 Retinoids 118 8.4.1.2 Benzoyl peroxide 119 8.4.1.3 Salicylic acid 120 8.4.1.4 Alpha and beta-hydroxy acids 120 8.4.2 Unclassified topicals 120 8.4.2.1 Azelaic acid 120 8.4.2.2 Sulfur 121 8.4.2.3 Zinc compounds 121 8.4.2.4 Resorcinol 121 8.4.3 Systemic comedolytics 121 8.4.3.1 Vitamin A 121 8.4.3.2 Isotretinoin 121 8.4.3.3 Acitretin 127 8.4.3.4 Summary 128 8.5 Anti-inflammatories and antimicrobials 128 8.5.1 Antibiotics as anti-inflammatories 128 8.5.1.1 In acne vulgaris 128 8.5.1.2 In acne rosacea 129 8.5.1.3 In acne inversa 129 8.5.1.4 In dissecting terminal folliculitis (DTF) and acne keloidalis 129 8.5.2 Antibiotics as antibiotics 130 8.5.3 Ketoconazole ivermectin and crotamiton 130 8.5.3.1 In acne vulgaris 132 8.5.3.2 In acne rosacea 133 8.5.3.3 In acne inversa/hidradenitis suppurativa and dissecting folliculitis and cellulitis 135 8.5.4 Steroids 135 8.5.4.1 The marine 136 8.5.5 Nonsteroidal anti-inflammatory drugs (NSAIDs) and biologics 137 8.5.6 Phototherapy 137 8.5.7 Post-inflammatory hyperpigmentation 138 8.5.7.1 Prognosis 141 8.6 Hormone manipulations and therapy 141 8.6.1 Birth control pill selection 141 8.6.1.1 Estrogens 142 8.6.1.2 Progestins 143 8.6.2 Androgen receptor blockade 143 8.6.2.1 Spironolactone 144 8.6.2.2 Cyproterone acetate 146 8.6.2.3 Flutamide 146 8.6.2.4 Drospirenone 146 8.6.2.5 Topical androgen blockers 147 8.6.3 Dihydrotestosterone minimization 147 8.6.3.1 Finasteride 147 8.6.3.2 Dutasteride 147 8.6.3.3 Diet 148 8.6.4 Phototherapy–hormone interactions 149 8.7 Surgery 150 8.7.1 Acne vulgaris 150 8.7.1.1 Acne surgery for patients 150 8.7.1.2 Acne surgery for physicians 151 8.7.2 Acne rosacea 152 8.7.3 Acne inversa/hidradenitis suppurativa 153 8.7.3.1 Mini-unroofing by punch biopsy 153 8.7.3.2 Unroofing 154 8.7.3.3 Wide surgical excision 157 8.7.3.4 Healing options 158 8.8 Lights and lasers 162 8.8.1 Light and other radiation in acne 162 8.8.1.1 Radiation’s targets 163 8.8.1.2 Light as a practical acne therapy 164 8.8.2 Lasers 165 9 Acne in pregnancy 171 9.1 Epidemiology 171 9.2 Pathogenesis 172 9.3 Team up with mother nature 173 9.4 Targeting therapy 173 9.4.1 Clinical manifestations 173 9.4.2 Pathology 173 9.4.3 Diagnostic evaluation 173 9.4.4 Overview and general approach to treatment 174 9.4.5 Milk and pregnancy 174 9.4.6 Active therapy 175 9.4.6.1 Avoidance of harm 175 9.4.6.2 Lesion-directed therapy 177 9.4.6.3 Nonprescription topicals 177 9.4.6.4 Antimicrobials 177 9.4.6.5 Combination topicals 178 9.4.6.6 Anti-inflammatories 178 9.4.6.7 Hormone blockers 178 9.4.6.8 Procedural therapies 179 9.5 Discussion 179 9.6 Summary and conclusion 179 10 Putting it all together 182 10.1 Lifestyle choices and the acnes 182 10.1.1 The “processed cheese queen” 184 10.2 Therapeutic choices and the acnes 184 10.2.1 Acne vulgaris 184 10.2.2 Acne rosacea 185 10.2.3 Acne inversa/hidradenitis suppurativa 185 10.3 Conclusion 186 11 Appendices 187 11.1 Appendix A: the rosacea “classification and staging” controversy 187 11.2 Appendix B: the dairy versus carbohydrate controversy 189 12 The handouts 193 12.1 Acne 194 12.2 The “zero-dairy” diet 197 12.3 The risks and benefits of isotretinoin 199 12.4 The paleo diet 204 12.5 Acne inversa/hidradenitis suppurativa (AI/HS) 209 12.6 Yasmin/Ocella/Zarah or Yaz/Gianvi extended cycle for acne therapy 213 Index 215
£85.46
John Wiley and Sons Ltd Behavioral Dentistry
Book SynopsisBehavioral Dentistry, Second Edition, surveys the vast and absorbing topic of the role of behavioral science in the study and clinical practice of dentistry. An understanding of social sciences has long been a central part of dental education, and essential for developing a clinician's appreciation of human behavior as it affects efficient dental treatment. This book gathers together contributions from leading experts in each of the major subspecialties of behavioral dentistry. Its aim is not merely to provide the student and clinician with a comprehensive review of the impressive literature or discussion of the theoretical background to the subject, but also with a practical guide to adapting the latest techniques and protocols and applying them to day-to-day clinical practice. This second edition of Behavioral Dentistry discusses biobehavioral processes, including the psychobiology of inflammation and pain, oral health and quality of life, saliva health,Trade Review“An interesting read and a must-read for undergraduates needing to know more about behaviour techniques. For the established practitioner, if there are certain patient groups you see with behavioural quirks you wish to know more about, most likely this book will cover it.” (British Dental Journal, 11 July 2014) Table of ContentsContributors ix Foreword xiiiHenrietta L. Logan Preface xvDavid I. Mostofsky and Farida Fortune Part I Biobehavioral Processes 1 1 Cultural Issues in Dental Education 3Vishal R. Aggarwal and Farida Fortune 2 Oral Health and Quality of Life 11Marita R. Inglehart 3 Stress and Inflammation 27Annsofi Johannsen and Anders Gustafsson 4 Saliva in Health and Disease 37Mahvash Navazesh 5 Surface EMG Biofeedback in Assessment and Functional Muscle Reeducation 49Bruce Mehler 6 Hypnosis in Dentistry 75Bruce Peltier Part II Anxiety, Fear, and Pain 87 7 Environmental, Emotional, and Cognitive Determinants of Dental Pain 89Daniel W. McNeil, Alison M. Vargovich, John T. Sorrell, and Kevin E. Vowles 8 Cosmetic Dentistry: Concerns with Facial Appearance and Body Dysmorphic Disorder 109Ad De Jongh 9 Chronic Orofacial Pain: Biobehavioral Perspectives 121Samuel F. Dworkin and Richard Ohrbach 10 Chairside Techniques for Reducing Dental Fear 141Ronald W. Botto, Evelyn Donate-Bartfield, and Patricia Nihill 11 Sleep and Awake Bruxism 153Alan G. Glaros and Cody Hanson 12 Dental Fear and Anxiety Associated with Oral Health Care: Conceptual and Clinical Issues 165Daniel W. McNeil and Cameron L. Randall Part III Changing Behaviors 193 13 Behavior Management in Dentistry: Thumb Sucking 195Raymond G. Miltenberger and John T. Rapp 14 Management of Children’s Distress and Disruptions during Dental Treatment 209Keith D. Allen and Dustin P. Wallace 15 Stress, Coping, and Periodontal Disease 227Gernot Wimmer and Walther Wegscheider 16 Self-Efficacy Perceptions in Oral Health Behavior 237Anna-Maija Syrjälä 17 Drooling and Tongue Protrusion 251Jan J. W. Van der Burg, Robert Didden, and Giulio E. Lancioni Part IV Professional Practice 265 18 Listening 267Bruce Peltier 19 Interpersonal Communication Training in Dental Education 283Toshiko Yoshida and Kazuhiko Fujisaki 20 Biopsychosocial Considerations in Geriatric Dentistry 293Georgia Dounis and David Cappelli 21 Health Behavior and Dental Care of Diabetics 323Mirka C. Niskanen and Matti L. E. Knuuttila 22 Oral Health Promotion with People with Special Needs 337Paul Glassman 23 The Use of Humor in Pediatric Dentistry 349Ari Kupietzky and Joseph Shapira 24 Work Stress, Burnout Risk, and Engagement in Dental Practice 363Ronald C. Gorter 25 Role of Dentists as Oral Physicians in Physical and Mental Health 373Donald B. Giddon and Ruth Hertzman-Miller Appendix Brief Relaxation Training Procedure for Use in Dentistry 389Ronald W. Botto Index 397
£53.15
John Wiley and Sons Ltd Lasers in Dentistry
Book SynopsisLasers have become an increasingly useful tool in conventional dental practice. Their precision and less invasive quality make them an attractive technology in esthetic and pediatric dentistry, oral medicine, and a range of other dental procedures.Table of ContentsList of contributors vii Foreword xii Preface xiii Section 1: Basic principles of lasers and LEDs 1 Physics of lasers and LEDs: Basic concepts 3Clóvis Grecco, José Dirceu Vollet-Filho, Mariana Torres Carvalho, and Vanderlei Salvador Bagnato 2 High power lasers and their interaction with biological tissues 11Denise Maria Zezell and Patricia Aparecida Ana 3 Low power lasers: Introduction 19Maria Cristina Chavantes, Martha Simões Ribeiro, and Nathali Cordeiro Pinto 4 Cellular mechanisms of photobiomodulation 23Tiina I. Karu 5 Low level laser therapy – mechanism of action: Inflammatory process 27Jan Magnus Bjordal Rodrigo Alvaro Brandão Lopes-Martins and Lucio Frigo 6 Low level laser therapy – mechanism of action: Analgesia 34Roberta Chow 7 Antimicrobial photodynamic therapy in dentistry 40Felipe F. Sperandio, Caetano P. Sabino, Daniela Vecchio, Maria Garcia-Diaz, Liyi Huang, Ying-Ying Huang, and Michael R. Hamblin 8 Dosimetry 48Jan Tunér, Martha Simões Ribeiro, and Alyne Simões 9 Risk management and the safe use of laser technology 56Rosely Cordon and Dalva Cruz Laganá Section 2: Preventive, esthetic, and restorative dentistry 10 Selective caries removal, cavity preparation and adhesion to irradiated tissues 65Patricia Moreira de Freitas, Marcelo Giannini, Junji Tagami, and Simone Gonçalves Moretto 11 Management of non-carious cervical lesions 72Ana Cecilia Corrêa Aranha, Karen Müller Ramalho, and Marcella Esteves-Oliveira 12 Antimicrobial photodynamic therapy for carious tissue 80Giselle Rodrigues de Sant’Anna and Danilo Antônio Duarte 13 Treatment of internal ceramic surfaces 88Carlos de Paula Eduardo, Marina Stella Bello-Silva, and Paulo Francisco Cesar 14 Dental bleaching with LEDs and lasers 92Fátima Zanin, Aldo Brugnera Jr, and Mateus Cóstola Windlin 15 Caries diagnosis 104Mariana Minatel Braga, Thais Gimenez, Fausto Medeiros Mendes, Christopher Deery, and David N. J. Ricketts 16 Lasers in caries prevention 126Lidiany Karla Azevedo Rodrigues, Patricia Moreira de Freitas, and Marinês Nobre-dos-Santos Section 3: Endodontics 17 Bacterial reduction in root canals using antimicrobial photodynamic therapy 133Aguinaldo S. Garcez and Silvia C. Núñez 18 High power lasers in apical surgery 139Sheila C. Gouw-Soares, José Luiz Lage-Marques, and Cláudia Strefezza 19 High power lasers in endodontics 143José Luiz Lage–Marques, Sheila C. Gouw Soares, and Cláudia Strefezza Section 4: Periodontology 20 Surgical and non-surgical treatment of periodontal diseases 153Leticia Helena Theodoro and Valdir Gouveia Garcia 21 Antimicrobial photodynamic therapy in the treatment of periodontal diseases 159Valdir Gouveia Garcia and Letícia Helena Theodoro 22 Esthetic treatment of gingival melanin hyperpigmentation with the Er:YAG laser 166Daniel Simões A. Rosa and Akira Aoki Section 5: Oral surgery 23 Lasers in soft tissues surgeries 175Luciane Hiramatsu Azevedo, Marines Sammamed Freire Trevisan, and Ana Maria Aparecida de Souza 24 Implantodontology 179Juliana Marotti and Georgios E. Romanos 25 Bone biomodulation 196Antonio Luiz Barbosa Pinheiro, Aparecida Maria Cordeiro Marques, Luiz Guilherme Pinheiro Soares, and Artur Felipe Santos Barbosa 26 Use of low level laser therapy in lymphatic drainage for edema 207Luciana Almeida-Lopes and Attilio Lopes Section 6: Orthodontics and orofacial pain 27 Temporomandibular disorders 223Caroline Maria Gomes Dantas and Carolina Lapaz Vivan 28 Low level lasers in orthodontics 229Marinês Vieira S. Sousa 29 Traditional Chinese medicine and laser therapy 238Mario Pansini, Fabiano Augusto Sfier de Mello, and Andrea Malluf Dabul de Mello Section 7: Treatment of oral and facial lesions 30 Papilloma and fibroma 245Luiz Alcino Gueiros, Igor Henrique Silva, Lucia de Fátima Cavalcanti dos Santos, and Jair Carneiro Leão 31 Hemangioma and lymphangioma 248Luciane Hiramatsu Azevedo and Cláudia Strefezza 32 Non-neoplastic proliferative lesions or soft tissue tumor-like lesions of the oral cavity 253Vivian Cunha Galletta Kern, Edgar Kazuyoshi Nakajima, Rodrigo Ramos Vieira, and Luciane Hiramatsu Azevedo 33 Oral mucocele 261Luciana Corrêa and Luciane Hiramatsu Azevedo 34 Potentially malignant disorders of the oral mucosa 265Vivian Cunha Galletta Kern, Ana Claudia Luiz, Edgar Nakajima, Luciane Hiramatsu Azevedo, and Dante Antonio Migliari 35 Herpes 272Juliana Marotti 36 Recurrent aphthous ulcers 285Leila Soares Ferreira and Daiane Thais Meneguzzo 37 Burning mouth syndrome 290Lucia de Fátima Cavalcanti dos Santos and Jair Carneiro Leão 38 Nerve repair by light 293Felipe F. Sperandio, Ying-Ying Huang, Nivaldo Parizotto, and Michael R. Hamblin Section 8: Laser and antimicrobial photodynamic therapies in cancer patients 39 Optical diagnosis of cancer and potentially malignant lesions 305Cristina Kurachi, Lilian Tan Moriyama, and Alessandro Cosci 40 Low level laser therapy in the prevention and treatment of oral mucositis 321Alyne Simões, Fernanda de Paula Eduardo, Cesar A. Migliorati, and Mark M. Schubert 41 Cost-effectiveness of laser therapyin hospital practice 331Leticia Mello Bezinelli and Luciana Corrêa 42 Low Level Laser Therapy for hyposalivation and xerostomia 335Alyne Simões, Luana de Campos, Victor Elias Arana-Chavez, and José Nicolau 43 Antimicrobial photodynamic therapy in cancerpatients 340Luana de Campos, Cesar A. Migliorati, and Alyne Simões 44 Photodynamic therapy in cancer treatment 346Juliana Ferreira-Strixino and Elodie Debefve Index 351
£100.76
John Wiley & Sons Inc Biosurfaces
Book SynopsisIdeal as a graduate textbook, this title is aimed at helping design effective biomaterials,taking into account the complex interactions that occur at the interface when a synthetic material is inserted into a living system. Surface reactivity, biochemistry,substrates, cleaning, preparation, and coatings are presented, with numerous case studies and applications throughout. Highlights include: Starts with concepts and works up to real-life applications such as implantable devices, medical devices, prosthetics, and drug delivery technology Addresses surface reactivity, requirements for surface coating, cleaning and preparation techniques, and characterization Discusses the biological response to coatings Addresses biomaterial-tissue interaction Incorporates nanomechanical properties and processing strategies Table of ContentsChapter 1. Introduction to Biomaterials 1.1 Introduction 1.2 Summary Chapter 2. Tissue Interaction with Biomaterials 2.1 Introduction 2.2 Protein adsorption and Cell adhesion 2.3 Cell Migration 2.4 Controlled Cell Deposition 2.5 Extracellular Matrix 2.6 Biomineralization Chapter 3. Host Response of Implanted Biomaterials 3.1 Immune Response to Implanted Biomaterials 3.2 Transplant Immunology 3.3 Biocomaptibility Chapter 4. Fundamentals of Surface Modification 4.1 Introduction 4.2 Surface Properties of Biomaterials 4.3 Surface modifications 4.4 Applications Chapter 5. Multi Length Scale Hierarchy in Natural Materials 5.1 Introduction 5.2 Multi Length-scale Hierarchy 5.3 Human Bone 5.4 Turtle shell 5.5 Wood 5.6 Silk 5.7 Nacre 5.8 Gecko-feet 5.9 Lotus Leaf Chapter 6. Superhydrophobic Surfaces 6.1 Introduction 6.2 Surfaces and superhydrophobicity in nature 6.3 Classification of surfaces 6.4 Mechanics and nature of wetting 6.5 Fabrication of artificial superhydrophobic surfaces 6.6 Preparation of metallic superhydrophobic surfaces 6.7 Controlled wettability surfaces (CWS) 6.8 Conclusions Chapter 7. Surface Engineering and Modification for Biomedical Applications 7.1 Corrosion of Biomaterials and Need for Surface Coating for Biomedical Applications 7.2 Surface Reactivity and Body Cell Response 7.3 Key Requirements of Surface Coating 7.4 Key Biomaterial Substrates 7.5 Surface Preparation and Cleaning Techniques 7.6 Surface Engineering and Coating Techniques 7.7 Coatings for Biomedical Applications 7.8. Biosurface Characterization Chapter 8. Laser Engineering of Surface Structures 8.1 Introduction 8.2 Laser processing of biomaterials 8.3 Laser-based prototyping methods 8.4 Ultrafast laser pulses 8.5 Neural implants 8.6 Ophthalmic implants 8.7 Laser fabrication of cardiovascular devices 8.8 Laser-fabricated nanoscale materials 8.9 Two photon polymerization 8.10 Microneedle fabrication 8.11 Conclusions Chapter 9. Processing and Nanomechanical Properties of Hydroxyapatite-Nanotube Biocomposite 9.1 Introduction 9.2 Processing of HA-Carbon Nanotube Composites 9.3 Fracture Toughness and Tribological Properties of HA-Carbon Nanotube Composites 9.4 Adhesion of Bone Forming Cells on HA-CNT Surface 9.5 Biomechanical Compatibility at Bone/Coated Implant Interface 9.6 HA-Boron Nitride Nano Tube (BNNT) Composites 9.7 HA-TiO2 Nanotube Composites 9.8 Summary Chapter 10. Applications of Biomaterials 10.1 Multi-scale hierarchy in natural Bone 10.2 Coronary Stents 10.3 Medical Devices 10.4 Drug Delivery Chapter 11. Nanosafety, Nanosocietal and Nanoethical Issues 11.1 Governmental Environment and Health Safety Organization Protocols 11.2 Related Safety Hazards 11.3 Approach to Developing Safety Protocol for Laboratory Environment 11.4 Tendency of Nanoparticles 11.5 Current Capability of Nanoparticle Filters
£121.46
John Wiley and Sons Ltd Improving Mental Health Care The Global Challenge
Book SynopsisWritten by many of the world's leading practitioners in the delivery of mental health care, this book clearly presents the results of scientific research about care and treatment for people with mental illness in community settings.Trade Review"Pausing to thank Michele for a career of service, yielding improvements in many parts of the world, seems eminently worthwhile. We encourage all mental health services researchers to read this book (Fig. 1." (Acta Psychiatrica Scandinavica, 24 March 2014) “Nevertheless many of the contributors show a strong understanding of the impact of mental ill-health on people’s lives, a wish to reduce that impact, and awareness of and respect for people’s rights (even though legal aspects are not discussed, as I describe above). In other words, though you may agree or not with some of the contributors, their humanity shines through, and as such the book is a wonderful and fitting tribute to the pioneer of mental health community care, Michele Tansella.” (Potential Unleashed, 6 October 2013)Table of ContentsContributors xii Section 1 The global challenge 1 1 The nature and scale of the global mental health challenge 3 Mirella Ruggeri, Graham Thornicroft and David Goldberg 2 Scaling up mental health care in resource-poor settings 12 Shekhar Saxena, Benedetto Saraceno and Justin Granstein 3 The swings and roundabouts of community mental health: The UK fairground 25 Peter Tyrer 4 Mental health services and recovery 40 Mike Slade, Mary Leamy, Victoria Bird and Clair Le Boutillier Section 2 Meeting the global challenge 57 5 Implementing evidence-based treatments in routine mental health services: Strategies, obstacles, new developments to better target care provided 59 Antonio Lasalvia, Sarah Tosato, Katia De Santi, Doriana Cristofalo, Chiara Bonetto and Mirella Ruggeri 6 The need for new models of care for people with severe mental illnessin low- and middle-income countries 78 Ruben Alvarado, Alberto Minoletti, Elie Valencia, Graciela Rojas and Ezra Susser 7 The role of primary care in low- and middle-income countries 96 David Goldberg, Graham Thornicroft and Nadja van Ginneken 8 Meeting the challenge of physical comorbidity and unhealthy lifestyles 114 Lorenzo Burti, Loretta Berti, Elena Bonfioli and Irene Fiorini 9 Complex interventions in mental health services research: Potential, limitations and challenges 131 Thomas Becker and Bernd Puschner 10 The feasibility of applying the clinical staging paradigm to the care of people with mental disorders 145 Javier Vázquez-Bourgon, Luis Salvador-Carulla, Benedicto Crespo-Facorro and José Luis Vázquez-Barquero 11 Work, mental health and depression 163 Aart Schene, Hiske Hees, Maarten Koeter and Gabe de Vries 12 Training mental health providers in better communication with their patients 180 Christa Zimmermann, Lidia Del Piccolo, Claudia Goss, Giuseppe Deledda, Mariangela Mazzi and Michela Rimondini 13 Making an economic case for better mental health services 193 Martin Knapp Section 3 New research methods 209 14 Incorporating local information and prior expert knowledge to evidence-informed mental health system research 211 Luis Salvador-Carulla, Carlos Garcia-Alonso, Karina Gibert and Javier Vázquez-Bourgon 15 Innovative epidemiological methods 229 Francesco Amaddeo, Valeria Donisi, Laura Grigoletti and Alberto Rossi 16 Routine outcome monitoring: A tool to improve the quality of mental health care? 246 Sjoerd Sytema and Lian van der Krieke 17 Psychiatric case registers: Their use in the era of global mental health 264 Povl Munk-Jørgensen and Niels Okkels 18 Can brain imaging address psychosocial functioning and outcome in schizophrenia? 281 Marcella Bellani, Nicola Dusi and Paolo Brambilla 19 Statistics and the evaluation of the effects of randomised health-care interventions 291 20 Service user involvement in mental health research 308 Diana Rose Section 4 Delivering better care in the community 317 21 Psychotropic drug epidemiology and systematic reviews of randomised clinical trials: The roads travelled, the roads ahead 319 Andrea Cipriani, Michela Nosè and Corrado Barbui 22 Services for people with severe mental disorders in high-income countries: From efficacy to effectiveness 340 Paul Bebbington, Elizabeth Kuipers and David Fowler 23 The management of mental disorders in the primary care setting 374 Matteo Balestrieri 24 Some wobbly planks in the platform of mental health care 394 Norman Sartorius 25 Treatment gaps and knowledge gaps in mental health: Schizophrenia as a global challenge 403 Assen Jablensky Index 424
£87.35
John Wiley and Sons Ltd Prostate Cancer
Book SynopsisDo you manage patients with prostate cancer? Could you use an expert guide examining all possible management options? Prostate Cancer: diagnosis and clinical management providesurologists and oncologists of all levels with up-to-date, evidence-based guidance to the diagnosis, treatment and clinical management of a disease which accounts for a quarter of all cancers affecting men. Designed to be as practical and accessible as possible, leading experts discuss key issues in prostate cancer management and examine how to deliver best practice in the clinical care of their patients. Topics covered include: What must be considered when counseling newly-diagnosed cancer patients Radical surgery options for prostate cancer Novel therapies for localized prostate cancer How should metastatic prostate cancer be diagnostic and managed What are the best methods of administering end of life caTable of ContentsContributors, vii Preface, x 1 Prostate Cancer Epidemiology, 1 Annie Darves-Bornoz, Joe Park, and Aaron Katz 2 Diagnosis and Screening, 16 Yiannis Philippou, Harveer Dev, and Prasanna Sooriakumaran 3 Understanding the Histopathology, 34 Jon Oxley 4 Markers in Prostate Cancer, 49 Philippa J. Cheetham 5 Imaging, 72 Jonathan Richenberg 6 Counseling the Patient with Newly Diagnosed Prostate Cancer, Stage by Stage, 116 Nicholas James Smith and William Richard Cross 7 Active Surveillance in the Management of Low-Risk Prostate Cancer, 136 L. Boccon-Gibod 8 Radical Surgery, 145 Adnan Ali and Ashutosh Tewari 9 Radiation Therapy in the Management of Prostate Cancer, 170 J. Conibear and P.J. Hoskin 10 Novel Therapies for Localized Prostate Cancer, 191 Massimo Valerio, Mark Emberton, Manit Arya, and Hashim U. Ahmed 11 Posttherapy Follow-up and First Intervention, 211 Ernesto R. Cordeiro, Anastasios Anastasiadis, Matias Westendarp, Jean J.M.C.H. de la Rosette, and Theo M. de Reijke 12 Managing Rising PSA in Naive and Posttherapy Patients, 230 George Thalmann and Martin Spahn 13 Diagnosis and Management of Metastatic Prostate Cancer, 245 Bertrand Tombal and Frederic Lecouvet 14 New Therapies in Hormone Relapsed Disease, 265 Carmel Pezaro, Aurelius Omlin, Diletta Bianchini, and Johann de Bono 15 End of Life Care in Prostate Cancer, 287 John D. Graham 16 The Long Perspective: Prostate Cancer as a Chronic Disease, 298 Peter Whelan 17 The Future: What’s in the Toolkit for Prostate Cancer Diagnosis and Treatment?, 313 Norman J. Maitland Index, 331 Color plate section can be found facing page 148
£67.46
John Wiley & Sons Inc BioInspired Materials for Biomedical Engineering
Book SynopsisThis book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine.Table of ContentsContributors vii Preface xi Introduction 1Sang Jin Lee and Anthony Atala Part I Engineering Bio-Inspired Material Microenvironments 5 Chapter 1 ECM-Inspired Chemical Cues: Biomimetic Molecules and Techniques of Immobilization 7Roger Y. Tam, Shawn C. Owen, and Molly S. Shoichet Chapter 2 Dynamic Materials Mimic Developmental and Disease Changes in Tissues 25Matthew G. Ondeck and Adam J. Engler Chapter 3 The Role of Mechanical Cues in Regulating Cellular Activities and Guiding Tissue Development 45Liming Bian Chapter 4 Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes 59Menekse Ermis, Erkan Türker Baran, Tuğba Dursun, Ezgi Antmen, and Vasif Hasirci Chapter 5 Cellular Responses to Bio-Inspired Engineered Topography 77Chelsea M. Kirschner, James F. Schumacher, and Anthony B. Brennan Chapter 6 Engineering The Mechanical and Growth Factor Signaling Roles of Fibronectin Fibrils 99Christopher A. Lemmon Chapter 7 Biologic Scaffolds Composed of Extracellular Matrix as a Natural Material for Wound Healing 111Elizabeth W. Kollar, Christopher L. Dearth, and Stephen F. Badylak Chapter 8 Bio-Inspired Integration of Natural Materials 125Albino Martins, Marta Alves da Silva, Ana Costa-Pinto, Rui L. Reis, and Nuno M. Neves Part II Bio-Inspired Tissue Engineering 151 Chapter 9 Bio-Inspired Design of Skin Replacement Therapies 153Dennis P. Orgill Chapter 10 Epithelial Engineering: From Sheets to Branched Tubes 161Hye Young Kim and Celeste M. Nelson Chapter 11 A Biomimetic Approach Toward The Fabrication of Epithelial-Like Tissue 175Hongjun Wang and Meng Xu Chapter 12 Nano- and Microstructured ECM and Biomimetic Scaffolds for Cardiac Tissue Engineering 195Quentin Jallerat, John M. Szymanski, and Adam W. Feinberg Chapter 13 Strategies and Challenges for Bio-Inspired Cardiovascular Biomaterials 227Elaine L. Lee and Joyce Y. Wong Chapter 14 Evaluation of Bio-Inspired Materials for Mineralized Tissue Regeneration Using Type I Collagen Reporter Cells 259Liisa T. Kuhn, Emily Jacobs, and A. Jon Goldberg Chapter 15 Learning from Tissue Equivalents: Biomechanics and Mechanobiology 281David D. Simon and Jay D. Humphrey Chapter 16 Mimicking the Hematopoietic Stem Cell Niche by Biomaterials 309Eike Müller, Michael Ansorge, Carsten Werner, and Tilo Pompe Chapter 17 Engineering Immune Responses to Allografts 327Anthony W. Frei and Cherie L. Stabler Chapter 18 Immunomimetic Materials 357Jamal S. Lewis and Benjamin G. Keselowsky Index 371
£123.50
John Wiley and Sons Ltd Cosmeceuticals and Cosmetic Practice
Book SynopsisAnti-aging skin care is an important part of dermatologic practice. The science behind the aging process has led to revolutionary changes in the treatment options available. Dermatologists can offer increasing numbers of combinations of pharmaceutical and cosmetic products. As choice increases so the possibility of confusion arises.Table of ContentsList of Contributors, vii Preface, xi 1 Cosmeceuticals and Clinical Practice, 1 Patricia K. Farris Part I Development, Formulation and Evaluation of Cosmeceuticals, 9 2 Bench to Beauty Counter: Development of Cosmeceuticals, 11 Alexandra Kowcz, Guenther Schneider, Wolfgang Pape, and Teresa M. Weber 3 Evaluating Cosmeceuticals, 23 David H. McDaniel, Christina Steel, and Chris Mazur 4 Modalities for Increasing Penetration, 37 Zoe Diana Draelos 5 Nanopharmaceuticals and Nanocosmeceuticals, 45 Adnan Nasir 6 Cutaneous Barrier Function, Moisturizer Effects and Formulation, 55 Dee Anna Glaser and Adam R. Mattox Part II Cosmeceutical Ingredients, 67 7 Cosmeceutical Uses and Benefits of Alpha, Poly and Bionic Hydroxy Acids, 69 Barbara A. Green 8 Vitamin A: Retinoids and the Treatment of Aging Skin, 81 Dana L. Sachs and John J. Voorhees 9 Vitamin C Cosmeceuticals, 94 Marianne N. O’Donoghue and Patricia K. Farris 10 Niacinamide: A Topical Vitamin with Wide-Ranging Skin Appearance Benefits, 103 Diane S. Berson, John E. Oblong, Rosemarie Osborne, Tomohiro Hakozaki, Mary B. Johnson, and Donald L. Bissett 11 Innovative Botanicals, 113 Jennifer David, Candrice R. Heath, and Susan Taylor 12 Green Tea Extract, 122 Neil Houston and Alexa Boer Kimball 13 Soy and Oatmeal-Based Cosmeceuticals, 133 Jason Emer and Heidi A. Waldorf 14 Bioactive Peptides, 142 Katie Rodan, Kathy Fields, and Timothy Falla 15 Growth Factors in Cosmeceuticals, 153 Sabrina G. Fabi and Hema Sundaram 16 Resveratrol and Synthetic Sirtuin Activators, 165 Patricia K. Farris 17 Skin Aging, Glycation and Glycation Inhibitors, 173 Patricia K. Farris 18 Essential Ions and Bioelectricity in Skin Care, 184 Ying Sun, Elizabeth Bruning, Susan H. Weinkle, and Samantha Tucker-Samaras 19 Stem Cell Cosmeceuticals, 192 Mark V. Dahl 20 Cosmeceutical Applications from Marine Organisms, 200 Sung-Hwan Eom and Se-Kwon Kim Part III Practical Applications for Cosmeceuticals, 209 21 Cosmeceuticals for the Treatment of Acne Vulgaris, 211 Joshua A. Zeichner 22 Cosmeceutical Skin Lighteners, 218 Marta I. Rendon, Yvette Vazquez, and Suzanne Micciantuono 23 Cosmeceuticals for Treating Cellulite, 226 Doris Hexsel and Camile L. Hexsel 24 Cosmeceuticals for Hair Loss and Hair Care, 234 Nicole E. Rogers 25 Cosmeceuticals for Treating and Preventing Scars, 245 Ellen Marmur and Katherine Nolan 26 Sun Protection and Self-Tanners, 252 Darrell S. Rigel 27 Cosmeceuticals for Rosacea and Facial Redness, 261 Doris Day 28 Cosmeceuticals for Enhancing Cosmetic Procedures, 268 Mary Lupo and Leah Jacob 29 The Future of Cosmeceuticals, 277 Patricia K. Farris Index, 283
£90.86
John Wiley and Sons Ltd Partnering for Recovery in Mental Health
Book SynopsisPartnering for Recovery in Mental Health is a practical guide for conducting person and family-centered recovery planning with individuals with serious mental illnesses and their families. It is derived from the authors' extensive experience in articulating and implementing recovery-oriented practice and has been tested with roughly 3,000 providers who work in the field as well as with numerous post-graduate trainees in psychology, social work, nursing, and psychiatric rehabilitation. It has consistently received highly favorable evaluations from health care professionals as well as people in recovery from mental illness. This guide represents a new clinical approach to the planning and delivery of mental health care. It emerges from the mental health recovery movement, and has been developed in the process of the efforts to transform systems of care at the local, regional, and national levels to a recovery orientation. It will be an extremely useful tool for plaTable of ContentsAcknowledgments ix Module 1: What is mental health recovery and how does it relate to person-centered care planning? 1 Module 2: Key principles and practices of person-centered care planning 23 Module 3: Preparing for the journey: Understanding various types of recovery plans and orienting participants to the PCCP process 53 Module 4: Strength-based assessment, integrated understanding, and setting priorities 71 Module 5: Creating the plan through a team meeting 91 Module 6: Documentation of PCCP: Writing the plan to honor the person AND satisfy the chart 113 Module 7: So you have a person-centered care plan, now what? Plan implementation and quality monitoring 147 Module 8: PCCP implementation: Common concerns and person-centered responses 181 Index 201
£33.20
John Wiley and Sons Ltd Interpreting Lung Function Tests
Book SynopsisLung function assessment is the central pillar of modern respiratory diagnosis, providing invaluable information to assist in clinical decision making and management strategies.Table of ContentsAbout the Authors vii Forewords ix Preface xi Acknowledgement xiii 1 General features of interpretation and report writing 1 2 Spirometry 13 3 Static lung volumes 37 4 Carbon monoxide transfer factor: single breath method 53 5 Tests of respiratory muscle strength 79 6 Bronchial provocation tests 99 7 The importance of quality tests 117 8 When the results do not fit the rules 139 Glossary 161 Index 165
£39.85
John Wiley & Sons Inc Integrated Biomaterials for Biomedical Technology
Book SynopsisThis cutting edge book provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications.Table of ContentsPreface xi 1. 1D~3D Nano-engineered Biomaterials for Biomedical Applications 1 Hui Chen, Xiaokang Li and Yanan Du 1.1 Introduction 1 1.2 3D Nanomaterials Towards Biomedical Applications 2 1.3 Structural and Functional Modification 6 1.4 Properties of Nanoparticles for Biomedical Application 8 1.5 Applications of NPs 10 1.6 2D Nanomaterials Towards Biomedical Applications 15 1.7 1D Nanomaterial Towards Biomedical Applications 21 1.8 Conclusion 28 References 28 2. Porous Biomaterials 35 Nasim Annabi 2.1 Introduction 35 2.2 Porosity and Pore Architecture of Biomaterial Scaffolds 36 2.3 Methods to Measure Porosity and Pore Size 38 2.4 Porosity Generation Techniques 39 2.5 Summary 60 References 61 3. Bioactive and Biocompatible Polymeric Composites Based on Amorphous Calcium Phosphate 67 Joseph M. Antonucci and Drago Skrtic 3.1 Introduction 68 3.2 Experimental Approach 75 3.3 Results and Discussion 91 3.4 Concluding Remarks/Future Directions 108 Acknowledgements 109 References 109 Appendix 1. List of Acronyms used Throughout the Proposal 117 4. Calcium Phosphates and Nanocrystalline Apatites for Medical Applications 121 Sunita Prem Victor and Chandra P. Sharma 4.1 Introduction 121 4.2 Chemistry of Calcium Phosphates 123 Contents vii 4.4 Properties of Calcium Orthophosphates 128 4.5 Biomedical Applications of Calcium Phosphates 133 4.6 Conclusion 138 References 138 5. SiO2 Particles with Functional Nanocrystals: Design and Fabrication for Biomedical Applications 145 Ping Yang 5.1 Introduction 145 5.2 Fabrication Methods of SiO2 Particles with NCs 156 5.3 Main Research Results for SiO2 Particles with NCs 170 5.4 Multifunctional SiO2 Particles for Biomedical Applications 229 5.5 Conclusions and Outlook 243 Acknowledgements 244 References 244 6. New Kind of Titanium Alloys for Biomedical Application 253 Yufeng Zheng, Binbin Zhang, Benli Wang and Li Li 6.1 Introduction 253 6.2 Dental Cast Titanium Alloys 254 6.3 Low Modulus Titanium Alloys 262 6.4 Nickel Free Shape Memory Titanium Alloys 266 6.5 Summary 270 References 270 7. BMP-based Bone Tissue Engineering 273 Ziyad S Haidar and Murugan Ramalingam 7.1 Introduction 274 7.2 Challenges in Protein Therapy 277 7.3 BMP Delivery Requirements 279 7.4 BMP-specific Carrier Types and Materials 282 7.5 Summary 289 Acknowledgements 290 References 290 8. Impedance Sensing of Biological Processes in Mammalian Cells 293 Lamya Ghenim, Hirokazu Kaji, Matsuhiko Nishizawa, Xavier Gidrol 8.1 Introduction 293 8.2 Cell Attachment and Spreading Processes 295 8.3 Cell Motility 299 8.4 Apoptosis 302 8.5 Mitosis 303 8.6 Single Cell Analysis 303 8.7 Conclusion 307 References 307 9. Hydrogel Microbeads for Implantable Glucose Sensors 309 Yun Jung Heo and Shoji Takeuchi 9.1 Introduction 9.2 Fabrication Methods of Hydrogel Microbeads 311 9.3 Fluorescence-based Glucose Monitoring 318 9.4 Biocompatibility 325 9.5 Summary 328 References 328 10. Molecular Design of Multifunctional Polymers for Gene Transfection 333 Chao Lin, Bo Lou and Rong Jin 333 10.1 Introduction 333 10.2 Barriers to Non-viral Gene Delivery 335 10.3 Molecular Design of Polymer Vectors for Efficient Gene Delivery 338 10.4 Molecular Design of Polymer Vectors with Low Cytotoxicity 348 10.5 Summary 354 Acknowledgements 355 Appendix: List of Abbreviations 355 References 355 11. Injectable in situ Gelling Hydrogels as Biomaterials 361 Hardeep Singh and Lakshmi S. Nair 11.1 Introduction 362 11.2 Injectable in situ Gelling Hydrogels 365 11.3 Clinical Applications of Hydrogels 369 11.4 Injectable Hydrogels for Biomedical Applications 370 11.5 Conclusions 393 References 393 12. Metal-polymer Hybrid Biomaterials with High Mechanical and Biological Compatibilities 399 Masaaki Nakai and Mitsuo Niinomi 12.1 Introduction 399 12.2 Fabrication Methods of Porous Titanium Filled with Medical Polymer 401 12.3 Mechanical Properties of Porous Titanium Filled with Medical Polymer 403 12.4 Biological Properties of Porous Titanium Filled with Medical Polymer 407 12.5 Summary 409 References 409
£166.46
John Wiley and Sons Ltd Manual of Minor Oral Surgery for the General
Book SynopsisThe Manual of Minor Oral Surgery for the General Dentist, Second Edition continues the aim of providing clear and practical guidance to common surgical procedures encountered in general practice.Table of ContentsContributors vii Preface ix 1 Patient Evaluation and History Taking 1Dale A. Baur Andrew Bushey and Diana Jee-Hyun Lyu 2 Management of the Patient with Medical Comorbidities 11 David W. Lui and David C. Stanton 3 Minimal Sedation for Oral Surgery and Other Dental Procedures 23Kyle Kramer and Jeffrey Bennett 4 Surgical Extractions 37Daniel Oreadi 5 Third Molar Extractions 55George Blakey 6 Pre-prosthetic Oral Surgery 85Antonia Kolokythas Jason Jamali and Michael Miloro 7 Evaluation and Biopsy Technique for Oral Lesions 103Marianela Gonzalez Thomas C. Bourland and Cesar A. Guerrero 8 Surgical Implantology 113Alfonso Caiazzo and Frederico Brugnami 9 Hard-Tissue Augmentation for Dental Implants 127Pamela Hughes 10 Soft Tissue Surgery for Dental Implants 135Hussam Batal 11 Surgical Crown Lengthening 165Serge Dibart 12 Endodontic Periradicular Microsurgery 169Louay Abrass 13 Dentoalveolar Trauma 225Omar Abubaker and Din Lam 14 Orofacial Infections 237Thomas R. Flynn 15 Complications of Dentoalveolar Surgery 265Patrick J. Louis Index 295
£78.26
John Wiley & Sons Inc Biomimetics
Book SynopsisProvides cutting-edge advances in biologically inspired, biomimetically-designed materials and systems for developing the next generation of nanobiomaterials and tissue engineering Humans have been trying to learn biomimetics for centuries by mimicking nature and its behaviors and processes in order to develop novel materials, structures, devices, and technologies. The most substantial benefits of biomimetics will likely be in human medical applications, such as developing bioprosthetics that mimic real limbs and sensor-based biochips that interface with the human brain to assist in hearing and sight. Biomimetics: Advancing Nanobiomaterials and Tissue Engineering seeks to compile all aspects of biomimetics, from fundamental principles to current technological advances, along with future trends in the development of nanoscale biomaterials and tissue engineering. The book details research, useful in inspiring new ideas, that seeks the principles and Table of ContentsList of Contributors xvii Preface xix Acknowledgements xxi 1 Biomimetic Polysaccharides and Derivatives for Cartilage Tissue Regeneration 1 Ferdous Khan and Sheikh Rafi Ahmad 1.1 Introduction 1 1.2 Strategies for Cartilage Tissue Engineering 3 1.3 Designing Scaffold for Cartilage Tissue Engineering 4 1.4 Natural Polysaccharides for Cartilage Tissue Engineering 8 1.5 Conclusions and Remarks on Prospects 17 References 18 2 Biomimetic Synthesis of Self-Assembled Mineralized Collagen-Based Composites for Bone Tissue Engineering 23 Xiumei Wang, Zhixu Liu and Fuzhai Cui 2.1 Introduction 23 2.2 Hierarchical Assembly of Mineralized CollagenFibrils in Natural Bone 25 2.3 Biomimetic Synthesis of Self-AssembledMineralized Fibrils 34 2.4 Applications of Mineralized Collagen-basedComposites for Bone Regeneration 40 2.5 Concluding Remarks 44 References 45 3 Biomimetic Mineralization of Hydrogel Biomaterials for Bone Tissue Engineering 51 Timothy E.L. Douglas, Elzbieta Pamula andSander C.G. Leeuwenburgh 3.1 Introduction 51 3.2 Incorporation of Inorganic Calcium PhosphateNanoparticles into Hydrogels 52 3.3 Biomimetic Mineralization in Calcium and/orPhosphate-Containing Solutions 56 3.4 Enzymatically-Induced Mineralization UsingAlkaline Phosphatase (ALP) 58 3.5 Enhancement of Hydrogel MineralizationUsing Biomacromolecules 60 3.6 Conclusions 62 References 63 4 Biomimetic Nanofibrous Scaffolds for Bone Tissue Engineering Applications 69 Robert J. Kane and Peter X. Ma 4.2 Self-Assembled Nanofiber Scaffolds 73 4.3 Electrospun Scaffolds 75 4.4 Thermally Induced Phase Separation (TIPS) Scaffolds 80 4.5 Overall Trends in Biomimetic Scaffold Design 84 References 85 5 Bioactive Polymers and Nanobiomaterials Composites for Bone Tissue Engineering 91 Ferdous Khan and Sheikh Rafi Ahmad 5.1 Introduction 92 5.2 Design and Fabrication of Biomimetic 3DPolymer-Nanocomposites Scaffolds 93 5.3 Nonbiodegradable Polymer and Nanocomposites 96 5.4 Biodegradable Polymer and Nanocomposites 102 5.5 Conclusions and Future Remarks 112 References 6 Strategy for a Biomimetic paradigm in Dental and Craniofacial Tissue Engineering Mona K. Mareil, Naglaa B. Nagy, Mona M. Saad, Samer H. Zaky, Rania M. Elbackly, Ahmad M. Eweida and Mohamed A. Alkhodary 6.1 Introduction 120 6.2 Biomimetics: Definition and Historical Background 121 6.3 Developmental Biology in Dental and Craniofacial Tissue Engineering: Biomimetics in Development and Growth (e.g. model of wound healing) 127 6.4 The Paradigm Shift in Tissue Engineering: Biomimetic Approaches to Stimulate Endogenous Repair and Regeneration 132 6.5 Extracellular Matrix Nano-Biomimetics for Craniofacial Tissue Engineering 136 6.6 Biomimetic Surfaces, Implications for Dental and Craniofacial Regeneration; Biomaterial as 6.7 Angiogenesis, Vasculogenesis, and Inosculation for Life-Sustained Regenerative Therapy; The Platform for Biomimicry in Dental and Craniofacial Tissue Engineering 143 6.8 Conclusion 149 Acknowledgements 150 References 150 7 Strategies to Prevent Bacterial Adhesion on Biomaterials 163 Indu Bajpai and Bikramjit Basu 7.1 Introduction 164 7.2 Characteristics of Prokaryotic Cells 166 7.3 Closure 194 Acknowledgement 195 References 195 8 Nanostructured Selenium – A Novel Biologically-Inspired Material for Antibacterial Medical Device Applications 203 Qi Wang and Thomas J. Webster 8.1 Bacterial Biofilm Infections on Implant Materials 204 8.2 Nanomaterials for Antibacterial Implant Applications 206 8.3 Selenium and Nanostructured Selenium 208 8.4 Selenium Nanoparticles for Antibacterial Applications 209 8.5 Summary and Outlook 215 References 216 9 Hydroxyapatite-Biodegradable Polymer Nanocomposite Microspheres Toward Injectable Cell Scaffold 221 Syuji Fujii, Masahiro Okada and Tsutomu Furuzono 9.1 Introduction 222 9.2 Pickering Emulsion 223 9.3 Fabrication of HAp-Polymer Nanocomposite Microspheres by Pickering Emulsion Method 226 9.4 Evaluation of Cell Adhesion Properties of HAp-Biodegradable Polymer Nanocomposite Microspheres 234 9.5 Application of HAp-Biodegradable Polymer Nanocomposite Microspheres as an Injectable Scaffold 235 9.6 Degradation Behavior of HAp-Biodegradable Polymer Nanocomposite Microspheres 237 9.7 Conclusions 238 Acknowledgments 238 References 239 10 Biomimetic ECM Scaffolds Prepared from Cultured Cells 243 Guoping Chen, Hongxu Lu and Naoki Kawazoe 10.1 Introduction 243 10.2 Cultured Cell-Derived ECM Porous Scaffolds 245 10.3 Autologous ECM Scaffolds 247 10.4 Application of Cultured Cell-Derived ECM Scaffolds 249 10.5 Summary 250 References 251 11 Design and Synthesis of Photoreactive Polymers for Biomedical Applications 253 Ponnurengam Sivakumar Malliappan, Di Zhou, Tae Il Son2 and Yoshihiro Ito 11.1 Introduction 253 11.2 UV-Reactive Biological Polymers 254 11.3 UV-Reactive Synthetic Polymers 263 11.4 Visible Light-Reactive Biopolymer Systems 270 11.5 Conclusions 274 References 274 12 The Emerging Applications of Graphene Oxide and Graphene in Tissue Engineering 279 Samad Ahadian, Murugan Ramalingam and Ali Khademhosseini 12.1 Introduction 280 12.2 Design and Fabrication of Biomimetic GO/Graphene Materials 283 12.3 Graphene Oxide and its Cell and TE Applications 284 12.4 Graphene and Its Cell and TE Applications 287 12.5 Conclusions and Future Directions 292 Acknowledgement 295 References 295 13 Biomimetic Preparation and Morphology Control of Mesoporous Silica 301 Qiang Cai 13.1 Introduction 302 13.2 Biomineralization and Biomimic Synthesis 302 13.3 Mesoporous Silica 306 13.4 Biomimic Preparation and Morphology Control of Mesoporous Silica 312 13.5 Conclusion and Prospective 324 References 325 14 Biomimetic Materials for Engineering Stem Cells and Tissues 329 Kaarunya Sampathkumar, Azadeh Seidi, Alok Srivastava, T.S. Sampath Kumar, Seeram Ramakrishna and Murugan Ramalingam 14.1 Introduction 330 14.2 Fabrication of Biomimetic Materials 331 14.3 Surface Modification 335 14.4 Engineering Stem Cells and Tissues 337 14.5 Concluding Remarks 341 Acknowledgements 342 References
£161.95
John Wiley and Sons Ltd Pediatric Urology
Book SynopsisPediatric Urology: Surgical Complications and Management, 2nd edition focuses 100% on the most common problems that can occur during pediatric urologic surgery, and how best to resolve them, ensuring the best possible outcome for the patient.Table of ContentsContributors vii Preface xii Part I Principles of Surgical Audit 1 How to set up prospective surgical audit 3Andrew Sinclair and Ben Bridgewater 2 Evaluating personal surgical audit and what to do if your results are not “as expected” 9Andrew Sinclair and Ben Bridgewater 3 A critical assessment of surgical outcomes 14Paul Merguerian 4 Implications of a poor surgical outcome 28Robert Wheeler Part II General Principles 5 Endocrine and metabolic response to surgery and its management 37Maurizio Pacilli and Ian E. Willetts 6 Perioperative anesthetic and analgesic risks and complications 48Mark Thomas Philippa Evans and Finn Nesbitt Part III Open Surgery of the Upper Urinary Tract 7 Nephrectomy 63Kathryn Evans and Mark Woodward 8 Partial nephrectomy 69Jonathan S. Ellison and John M. Park 9 Ureteropelvic junction obstruction 76Amy Hou and Jenny H. Yiee 10 Complications of antirefl ux surgery 87Angela M. Arlen Anthony A. Caldamone and Andrew J. Kirsch 11 Ureteral surgery: ureteroureterostomy and transureteroureterostomy 96Joseph M. Gleason Job K. Chacko and Martin A. Koyle Part IV Surgery of the Bladder 12 Complications: epispadias and bladder exstrophy 107Ardavan Akhavan Ahmad Elderwy and Richard Grady 13 Umbilical and urachal anomalies 116Paul F. Austin Part V Endoscopic Surgery of the Urinary Tract 14 Cystoscopy and cystoscopic interventions 125Divyesh Y. Desai and Neil C. Featherstone 15 Interventional procedures of the genitourinary tract 138Dimitri A. Parra 16 Minimally invasive interventions for stone disease 147Naima Smeulders and Shabnam Undre 17 General laparoscopy 161Chris Kimber and Nathalie Webb 18 Complications of laparoscopic surgery of the upper urinary tract 167Walid A. Farhat and Elias Wehbi 19 Complications of laparoscopic surgery of the lower urinary tract 177Paul H. Noh 20 Complications of robotic surgery of the urinary tract 182Kelly A. Swords and Craig A. Peters Part VI Genitalia 21 Hernia and hydrocele repair 193Henrik Steinbrecher and Marie-Klaire Farrugia 22 Orchidopexy and orchidectomy 200Kim A. R. Hutton and Ahmed A. Darwish 23 Laparoscopic orchidopexy 216Janelle A. Fox Steven G. Docimo and Michael C. Ost 24 Varicocele 234Ramnath Subramaniam 25 Complications of newborn circumcision: prevention diagnosis and treatment 245Andrew L. Freedman and Richard S. Hurwitz 26 Surgical complications of hypospadias and their management 259Warren T. Snodgrass and Nicol C. Bush 27 Phalloplasty for the biological male 270Piet Hoebeke Nicolaas Lumen and Stan Monstrey 28 Complications of female genital surgery and disorders of sex development I 281Lina Michala and Sarah M. Creighton 29 Complications of female genital surgery and disorders of sex development II 288Joao L. Pippi Salle and Rodrigo L. P. Romao 30 Persistent cloaca 298Stephanie A. Warne Part VII Renal Impairment Surgery 31 Hemodialysis and peritoneal dialysis 307Alun Williams 32 Kidney transplantation 315Alun Williams 33 Wilms tumor and other renal tumors 325Mark Tyson and Michael Ritchey 34 Rhabdomyosarcoma and related pelvic tumors of the genitourinary tract 332Miriam Harel and Fernando Ferrer 35 Testicular tumors 341Lynn L. Woo and Jonathan H. Ross Part IX Trauma 36 Genital trauma 355David J. Chalmers and Vijaya M. Vemulakonda 37 Urinary tract trauma 364W. Robert DeFoor Jr Ashok Rijhwani and Eugene Minevich Part X Surgery for Urinary Incontinence 38 Augmentation cystoplasty and diversion 377Blake W. Palmer and Bradley P. Kropp 39 Appendicovesicostomy and ileovesicostomy 384Martin Kaefer 40 Surgery for fecal incontinence 398Elizabeth Malm-Buatsi and Dominic Frimberger 41 Surgical problems in transitional care 404Dan Wood Index 413
£102.56
John Wiley & Sons Inc Biomedical Devices
Book SynopsisBiomedical Devices: Design, Prototyping, and Manufacturing features fundamental discussions of all facets of materials processing and manufacturing processes across a wide range of medical devices and artificial tissues. Represents the first compilation of information on the design, prototyping, and manufacture of medical devices into one volume Offers in-depth coverage of medical devices, beginning with an introductory overview through to the design, manufacture, and applications Features examples of a variety of medical applications of devices, including biopsy micro forceps, micro-needle arrays, wrist implants, spinal spacers, and fixtures Provides students, doctors, scientists, and technicians interested in the development and applications of medical devices the ideal reference source Table of ContentsCONTRIBUTORS ix FOREWORD xi 1 Overview 1Joaquim De Ciurana Gay, Tu¢grul Özel, and Lidia Serenó 1.1 Introduction, 1 1.2 Need for Medical Devices, 7 1.3 Technology Contribution to Medical Devices, 12 1.3.1 Subtractive Technologies, 13 1.3.2 Net-Shape Technologies, 13 1.3.3 Additive Technologies, 14 1.4 Challenges in the Medical Device Industry, 16 References, 17 2 Design Issues in Medical Devices 23Inés Ferrer, Jordi Grabalosa, Alex Elias-Zuñiga, and Ciro Angel Rodriguez 2.1 Medical Device Development (MDD), 23 2.1.1 Biomedical Product Life Cycle, 24 2.1.2 Medical Device Development Process, 27 2.1.3 Medical Devices’ Design Process, 28 2.2 Case Study, 30 2.2.1 Scapholunate Interosseous Ligament, 30 2.2.2 Conceptual Design, 32 2.2.3 Embodiment Design, 35 2.2.4 Detailed Design, 36 2.2.5 Manufacturing a Prototype, 36 2.2.6 Tracheal Stent, 38 2.2.7 Conceptual Design, 39 2.2.8 Embodiment Design and Detail Design, 43 2.2.9 Manufacturing a Prototype, 45 2.3 Conclusions, 45 References, 46 3 Forming Applications 49Karen Baylón, Elisabetta Ceretti, Claudio Giardini, and Maria Luisa Garcia-Romeu 3.1 Forming, 49 3.2 Typical Process Parameters, 52 3.2.1 Temperature, 52 3.2.2 Flow Stress, 53 3.2.3 Strain, 53 3.2.4 Strain Rate, 54 3.2.5 Tribology and Micro-Tribology, 54 3.3 Manufacturing Process Chain, 55 3.3.1 Manufacture of Alloys and Raw Materials, 55 3.3.2 Forming, 56 3.3.3 Machining and Finishing, 56 3.3.4 Coating, 56 3.3.5 Packaging and Sterilization, 56 3.4 Implantable Devices, 56 3.5 Bone Implants, 57 3.5.1 External Fracture Fixation, 57 3.5.2 Artificial Joint Replacement, 58 3.5.3 Spinal Implants, 68 3.5.4 Craniomandibular Implants, 68 3.5.5 Dental Implants, 71 3.6 Other Biomedical Applications, 73 References, 74 4 Laser Processing Applications 79Tu¢grul Özel, Joaquim De Ciurana Gay, Daniel Teixidor Ezpeleta, and Luis Criales 4.1 Introduction, 79 4.2 Microscale Medical Device Applications, 80 4.3 Processing Methods for Medical Device Fabrication, 82 4.4 Biomaterials Used in Medical Devices, 86 4.5 Microjoining of Similar and Dissimilar Materials, 86 4.6 Laser Micromachining for Microfluidics, 89 4.7 Laser Micromachining for Metallic Coronary Stents, 92 References, 94 5 Machining Applications 99Tu¢grul Özel, Elisabetta Ceretti, Thanongsak Thepsonthi, and Aldo Attanasio 5.1 Introduction, 99 5.2 Machinability of Biocompatible Metal Alloys, 102 5.3 Surfaces Engineering of Metal Implants, 104 5.4 Wear and Failure of Metal Implants, 105 5.5 Micromilling-Based Fabrication of Metallic Microchannels for Medical Devices, 106 5.6 Machining-Based Fabrication of Polymeric Microneedle Devices, 109 5.7 A Case Study: Milling-Based Fabrication of Spinal Spacer Cage, 110 5.7.1 Degenerative Disc Disease, 112 5.7.2 Intervertebral Spinal Spacers, 113 5.7.3 Prototype Fabrication Using Milling Process, 115 References, 118 6 Inkjet- and Extrusion-Based Technologies 121Karla Monroy, Lidia Serenó, Joaquim De Ciurana Gay, Paulo Jorge Bártolo, Jorge Vicente Lopes Da Silva, and Marco Domingos 6.1 Introduction, 121 6.2 Inkjet Technology, 124 6.2.1 Inkjet 3D Printing Technology, 125 6.2.2 Materials in Inkjet-Based Technologies, 128 6.2.3 Inkjet Printing Methods, 130 6.2.4 Inkjet Printing Systems: Processes and Machines, 131 6.2.5 Medical Applications of Inkjet Technology, 135 6.3 Material Extrusion Technology, 139 6.3.1 Material Extrusion—General Principles, 139 6.3.2 Extrusion-Based Technologies, 144 6.3.3 Medical Applications of Extrusion-Based Systems, 153 References, 156 7 Certification for Medical Devices 161Corrado Paganelli, Marino Bindi, Laura Laffranchi, Domenico Dalessandri, Stefano Salgarello, Antonio Fiorentino, Giuseppe Vatri, and Arne Hensten 7.1 Introduction, 161 7.2 The Medical Devices Approval, Registration, or Certification, 163 7.3 The Premarket Key Activity: The Demonstration of the Conformity to the Safety and Performance Requirements, 163 7.4 The Postmarket Key Activity: The Surveillance, 165 7.5 The Role of the Quality Management Systems, 165 7.6 The Verification and the Auditing, 166 7.7 The Role of the Standards, 167 7.8 Examples of Approbation/Certification Roads in Some World Areas, 168 7.8.1 European Union, 168 7.8.2 United States of America, 168 7.8.3 Japan, 168 7.8.4 Australia, 169 7.8.5 Brazil, 169 7.8.6 Canada, 169 7.9 In-Depth Studies, 170 7.9.1 Essentials of Safety and Performance Principles, 170 7.9.2 Essentials of the Risk Management, 174 7.9.3 Essentials of the Nonclinical Evaluation, 175 7.9.4 Essentials of the Clinical Evaluation, 178 References, 181 INDEX 183
£91.15
John Wiley and Sons Ltd Diagnostic Imaging of Infections and Inflammatory
Book SynopsisThoroughly and systematically presents the state-of-the-art in the diagnostic uses of radiologic imaging and nuclear medicine in the diagnosis and management of infectious and inflammatory diseases Although our understanding of microorganisms has advanced significantly and antimicrobial therapy has become increasingly available, infection remains a major cause of patient morbidity and mortality. Imaging of infection and inflammation provides a classic example of radiology and nuclear medicine's strengths as well as weaknesses in the discovery and diagnosis of disease. Fortunately, the weaknesses are subsiding as new studies and techniques point to better planning and precision in the use of single and combined imaging modalities. Diagnostic Imaging of Infections and Inflammatory Diseases: A Multidisciplinary Approach deals with the very latest developments in the use of radiologic techniques and modalities in the management of patients with a host of infectiousTable of ContentsList of Contributors, vii Foreword, ix Preface, x Part I Infections and Host Response 1 Epidemiology of Infections in the New Century, 3 Nicola Petrosillo 2 Bacterial Osteomyelitis: The Clinician’s Point of View, 15 Ilker Uçkay, Nicolas Christian Buchs, Khalid Seghrouchni, Mathieu Assal, Pierre Hoffmeyer and Daniel Lew Part II Radiological Imaging 3 Radiological Imaging of Osteomyelitis, 29 Jenny T. Bencardino, Zoraida Restrepo-Velez, Randall Bujan and Diego Jaramillo 4 Radiological Imaging of Spine Infection, 54 Ana María Quintero and Roy Riascos 5 Radiological Imaging of Soft Tissue Infections, 75 Carolina Whittle and Giancarlo Schiappacasse 6 Radiological Imaging of Abdominal Infections and Inflammatory Disease, 91 Carolina Whittle, Giancarlo Schiappacasse and Francesca Maccioni 7 Radiological Imaging of Vascular Graft Infection, 118 Alejandro Romero, Tobias Zander, Jorge Lopera, Sergi Quiroga and Manuel Maynar 8 Radiological Imaging of Tuberculosis and Human Immunodefi ciency Virus, 135 Jorge Carrillo Part III Nuclear Medicine Imaging 9 Nuclear Medicine Imaging of Infections: Techniques, Acquisition Protocols and Interpretation Criteria, 149 Alberto Signore 10 Nuclear Medicine Imaging of Osteomyelitis: White Blood Cell, Monoclonal Antibody, or Bacterial Imaging?, 168 Christopher J. Palestro 11 Nuclear Medicine Imaging of Spondylodiscitis: The Emerging Role of PET, 187 Elena Lazzeri, Paola Anna Erba, Martina Sollini and Giuliano Mariani 12 Nuclear Medicine Imaging of Soft Tissue Infections, 199 Bárbara Morales Klinkert 13 Nuclear Medicine Imaging of Infections and Inflammatory Diseases of the Abdomen, 216 Josep Martín Comín, Alba Rodríguez Gasén and Christophe Van de Wiele 14 Nuclear Medicine Imaging of Vascular Graft Infection: The Added Role of Hybrid Imaging, 241 Ora Israel 15 Nuclear Medicine Imaging of Tuberculosis and Human Immunodeficiency Virus, 255 Mike Sathekge, Christophe Van de Wiele and Alberto Signore 16 Nuclear Medicine Imaging of Fever of Unknown Origin, 273 François-Xavier Hanin and François Jamar 17 Nuclear Medicine Imaging of Inflammatory Diseases, 291 Marco Chianelli, Gaurav Malviya, Andor W.J.M. Glaudemans and Alberto Signore Index, 323
£119.70
John Wiley & Sons Inc ABC of Alcohol
Book SynopsisThe misuse of alcohol presents both individual physical and psychological problems as well as wider social consequences. Alcohol misuse is a frequent cause of attendance in accident and emergency departments and an underlying factor in a range of long term and chronic conditions commonly treated and managed within primary care settings.Table of ContentsContributors vii Preface ix 1 Alcohol use: Consumption and costs 1Peter McGovern and Eric Appleby 2 Alcohol use: Society and politics 7Peter McGovern and Eric Appleby 3 Alcohol in the body 12Alex Paton and Anne McCune 4 Definitions 15Alex Paton 5 The nature of alcohol use disorders 19John B. Saunders 6 The detection of alcohol use disorders 25John B. Saunders 7 Medical problems 33Alex Paton 8 Problems in the Emergency Department – and their solutions 37Zulfiquar Mirza and Robin Touquet 9 Alcohol and the young person 42William Christian, Sian Veysey and Anne Frampton 10 Alcohol and the older person 46Jarrod Richards and Rachel Bradley 11 Alcohol and the liver 50Anne McCune 12 Surgical problems 56James S. Huntley 13 Alcohol, maxillofacial trauma and prevention of personal violence 61Jonathan Shepherd and Paul Jordan 14 Neurological and neurosurgical complications of alcohol 64Jane Alty and Jeremy Cosgrove 15 Alcohol and cancer 69Sarah L. Williams 16 Alcohol and the heart 74Nitin Kumar, Yasmin Ismail and Julian Strange 17 Drug–alcohol interactions 79Dan Harris 18 Management of acute unplanned alcohol withdrawal 84Adrian Brown and Anne McCune 19 The role of alcohol care teams in district general hospitals 89Kieran J. Moriarty 20 Management in primary care 95Carsten Grimm 21 Advice and counselling 99Nicola Taylor 22 Psychological treatment and relapse prevention 102Nicola Taylor 23 Alcohol and psychiatry 105Nicola Taylor 24 Other resources, and alcohol and the doctor 109Nicola Taylor Index 000
£26.55
John Wiley and Sons Ltd Practical Psychodermatology
Book SynopsisHow do you help a dermatological patient with a psychological reaction? How do you differentiate psychological causes from true skin disease? This book deals with these challenges that ask dermatologists, psychiatrists, psychologists and other health care specialists to collaborate.Trade Review“Concise, well-organized, and approachable, Practical Psychodermatology will prove to be a useful reference for any dermatologist seeking to improve or solidify their management of the skin-psyche interface.” (Journal of the American Academy of Dermatology, 1 May 2015) “Overall this was a fascinating book, containing a vast amount of information and practical suggestions for managing complicated patients.” (British Journal of Dermatology, 1 May 2015) Table of ContentsContributors, vii Foreword, xi Preface, xiii Section 1: Introduction 1 Introduction, 3Anthony Bewley, Michelle Magid, Jason S. Reichenberg and Ruth E. Taylor 2 History and examination, 11Ruth E. Taylor, Jason S. Reichenberg, Michelle Magid and Anthony Bewley Section 2: Management in psychodermatology 3 Psychopharmacology in psychodermatology, 21Sussann Kotara, Michelle Magid and Maureen Burrows 4 Adherence in the treatment of chronic skin diseases, 33Laura F. Sandoval, Christine S. Ahn and Steven R. Feldman 5 Psychological assessment and interventions for people with skin disease, 40Reena B. Shah 6 Risk and risk management in psychodermatology, 50William H. Reid and Simon Kirwin 7 Self-help for management of psychological distress associated with skin conditions, 60Andrew R. Thompson 8 Habit reversal therapy: a behavioural approach to atopic eczema and other skin conditions, 66Christopher Bridgett 9 Nursing interventions in psychodermatology, 72Fiona Cowdell and Steven Ersser Section 3: Skin diseases with secondary psychiatric disorders 10 Psychological impact of hair loss, 81Paul Farrant and Sue McHale 11 Psoriasis and psychodermatology, 90Christine Bundy, Lis Cordingley and Chris Griffi ths 12 Living well with a skin condition: what it takes, 97Henrietta Spalding, Wendy Eastwood, Krysia Saul and Susan Bradbrooke 13 Chronic skin disease and anxiety, depression and other affective disorders, 104Steven Reid and Wojtek Wojcik Section 4: Psychiatric disorders with secondary skin manifestations 14 Delusional infestation, 117Peter Lepping, Roland Freudenmann and Markus Huber 15 Body dysmorphic disorder, 127Emma Baldock and David Veale 16 Pickers, pokers, and pullers: obsessive-compulsive and related disorders in dermatology, 134Jonathan S. Abramowitz and Ryan J. Jacoby 17 Factitious skin disorder (dermatitis artefacta), 142Jonathan Millard and Leslie Millard Section 5: Cutaneous sensory (pain) disorders 18 Medically unexplained symptoms and health anxieties: somatic symptom and related disorders, 153Angharad Ruttley, Audrey Ng and Anna Burnside 19 Dysesthetic syndromes, 164Sara A. Hylwa, Mark D.P. Davis and Mark R. Pittelkow 20 Chronic idiopathic mucocutaneous pain syndromes: vulvodynia, penodynia, and scrotodynia, 173Peter J. Lynch and Libby Edwards 21 Burning mouth syndrome, 180Alison Bruce, Rochelle R. Torgerson, Cooper C. Wriston and Tania M. Gonzalez Santiago 22 Nodular prurigo, 186Wei Sheng Tan, Hong Liang Tey and Mark B.Y. Tang Section 6: Special populations and situations 23 Child and adolescent psychodermatology, 197Birgit Westphal and Osman Malik 24 Psychodermato-oncology: psychological reactions to skin cancer, 206Andrew G. Affleck and Lesley Howells 25 Botulinum toxin treatment in depression, 216M. Axel Wollmer, Michelle Magid and Tillmann H.C. Kruger 26 The Morgellons debate, 220Jason S. Reichenberg and Michelle Magid 27 Substance misuse and the dermatology patient, 224Alexander Verner Glossary, 231 Appendix: Screening questionnaires and scales, 238 Index, 268
£97.16
John Wiley & Sons Inc Essential Clinical Guide to Understanding and
Book SynopsisCoauthored by the premier expert on autism in the United States and an experienced academic and practicing pediatrician, this volume provides concise and practical information based on the most up-to-date research and clinical experience for primary care givers around the world.Table of ContentsPREFACE vii CHAPTER 1 What Is Autism: Diagnostic Concepts, Causes, and Current Research 1 CHAPTER 2 Screening and Diagnostic Assessment 25 CHAPTER 3 Approaches to Providing Medical Care 49 CHAPTER 4 Frequent Medical Conditions and Problems 67 CHAPTER 5 Overview of Educational Programs and Interventions 93 CHAPTER 6 Securing Services 121 CHAPTER 7 Autism in Infants and Preschool Children 145 CHAPTER 8 School-Age Children 171 CHAPTER 9 Adolescents and Adults 201 CHAPTER 10 Behavioral and Psychiatric Problems: Issues and Interventions 219 CHAPTER 11 Considering Medications for Behavior and Mental Health Problems 245 CHAPTER 12 Considering Complementary and Alternative Treatments 271 CHAPTER 13 Supporting Families 291 APPENDIX 1 Diagnostic Descriptions and Criteria for Autism and Related Pervasive Developmental Disorders 309 APPENDIX 2 Understanding School and Specialist Assessment 315 GLOSSARY 331 INDEX 339
£44.96
John Wiley and Sons Ltd Health Care Reform in Radiology
Book SynopsisThe first book-length treatment of this absolutely essential topic, Health Care Reform in Radiology provides a cogent, concise discussion of major issues related to health care reform from the perspective of fellow imaging specialists.Table of ContentsContributors vii Preface viii 1 Health Care Reform: The Scope of the Problem 1Richard C. Semelka, Diane Armao, and Jorge Elias Jr 2 Only Studies Which are Necessary 6Diane Armao, Jorge Elias Jr, and Richard C. Semelka 3 Radiation Dose Reduction 22Jorge Elias Jr and Richard C. Semelka 4 Alternate Imaging Studies To CT 36Jorge Elias Jr, Lauren M. B. Burke, and Richard C. Semelka 5 Patient Information 64Jorge Elias Jr and Richard C. Semelka 6 Are we Doing the Right Study? 86Diane Armao, Jorge Elias Jr, and Richard C. Semelka 7 Radiology Medical Education 115Jorge Elias Jr and Richard C. Semelka 8 Quality Metrics for Radiology Practice 123Richard C. Semelka and Jorge Elias Jr 9 Medicolegal Reform 140Jorge Elias Jr and Richard C. Semelka 10 Pressures on Reduced Compensation For Clinical Service 151Jorge Elias Jr and Richard C. Semelka 11 National Health Care Systems 159Jorge Elias Jr, Lauren M. B. Burke, and Richard C. Semelka 12 Research In Radiology 170Richard C. Semelka, Michael Brand, Michael Uder, Michael A. Kuefner, John Stonestreet and Jorge Elias Jr Subject index 195 Color Plate Section can be Found Facing Page 184
£67.46
John Wiley and Sons Ltd Physical Evaluation and Treatment Planning in
Book SynopsisTable of ContentsPreface to the Second Edition ix Preface to the First Edition xi List of Contributors xiii About the Companion Website xv 1 Introduction to the Clinical Process 1 1.1 Essential Elements of the Clinical Process 1 1.2 Quality Management in the Clinical Process 2 1.3 Patient–Doctor Communication in the Clinical Process 3 1.4 Characteristics of the Patient–Doctor Relationship 6 1.5 Documentation of the Clinical Process 6 1.6 Designations and Abbreviations 10 1.7 Summary 18 Suggested Reading 18 2 The Historical Profile 19 2.1 Patient Identification 20 2.2 Chief Complaint (Problem) 20 2.3 Dental History 21 2.4 Medical History 21 2.5 Family History 22 2.6 Social History 22 2.7 Review of Organ Systems 23 2.8 Summary 35 Suggested Reading 36 3 Basic Procedures in Physical Examination 39 3.1 Inspection 39 3.2 Palpation 53 3.3 Percussion 53 3.4 Auscultation 54 3.5 Olfaction 54 3.6 Evaluation of Function 54 3.7 Summary 61 Suggested Reading 61 4 Examination of the Head and Neck 63 4.1 Examine the Head and Face 63 4.2 Examine the Ears and Temporomandibular Joints 98 4.3 Examine the Nose 99 4.4 Examine the Eyes 101 4.5 Examine the Hair 106 4.6 Examine the Neck 109 4.7 Examine the Lymph Nodes 113 4.8 Conclusion 116 Suggested Reading 117 5 Examination of the Oral Cavity 123 5.1 Examine the Vermilion of the Lips 123 5.2 Examine the Labial and Buccal Mucosa 131 5.3 Examine the Hard Palate 142 5.4 Examine the Soft Palate and Tonsillar Area 149 5.5 Examine the Tongue 152 5.6 Examine the Glossopharyngeal (IX) and Vagus (X) Nerves 157 5.7 Examine the Floor of the Mouth 158 5.8 Examine the Gingivae 161 5.9 Examine the Teeth 168 5.10 Summary 171 Suggested Reading 172 6 Radiographic Examination 177 6.1 Radiographic Examination of the New Patient 178 6.2 Radiographic Examination of the Recall Patient 179 6.3 Introduction to Radiographic Interpretation 180 6.4 Radiographic Manifestations of Common Conditions 181 6.5 Conclusion 201 Suggested Reading 201 7 Laboratory Methods 203 7.1 Hematology Screening 204 7.2 Evaluation of Hemostasis 205 7.3 Biochemical Tests 208 7.4 Tissue Studies 211 7.5 Summary 214 Suggested Reading 214 8 Diagnostic and Treatment Planning Considerations for Orofacial Pain 215 8.1 Subjective Information 216 8.2 Objective Findings 217 8.3 Plan: Treatment Options 221 8.4 Summary 224 Suggested Reading 224 9 Evidence-Based Treatment Planning in Restorative Dentistry 227 9.1 Historical Perspective 227 9.2 Etiology of Dental Caries 228 9.3 Caries Lesion Detection, Assessment and Diagnosis 230 9.4 Primary Caries Lesion Diagnosis and Risk Assessment 234 9.5 Developing a Minimally Invasive Evidence-Based Treatment Plan Predicated on Caries Risk 235 9.6 Diagnosis and Treatment of Root Caries Lesions 241 9.7 Clinical Detection and Diagnosis of Secondary or Recurrent Caries Lesions 242 9.8 Repair Versus Replacement of Direct Restorations 243 9.9 Summary 244 Suggested Reading 244 10 Periodontal and Peri-Implant Examination 249 10.1 Periodontal Evaluation 250 10.2 Establishing a Periodontal Diagnosis 256 10.3 Basic Principles of Periodontal Treatment Planning 262 10.4 Peri-Implant Examination and Diagnosis 264 10.5 Summary 264 References 265 11 Oral and Maxillofacial Surgery 269 11.1 Introduction 269 11.2 Medical History 270 11.3 Chief Complaint (CC) 270 11.4 History of Present Illness (HPI) 270 11.5 Past Medical History 271 11.6 Past Surgical History 271 11.7 Medications 271 11.8 Allergies 271 11.9 Social History 272 11.10 Last Meal 272 11.11 Review of Systems (ROS) 272 11.12 Physical Examination 272 11.13 Medical Status 275 11.14 Anesthesia Requirements 276 References 294 12 Endodontic Evaluation 295 12.1 Introduction 295 12.2 Pulp Status 297 12.3 Periradicular Status 299 12.4 Imaging Assessment 302 12.5 Additional Clinical Evaluations 303 12.6 Diagnosis 304 12.7 Endodontic Treatment Planning 306 12.8 Concluding Remarks 311 References 311 13 Prosthodontic Restoration 313 13.1 Documenting Patient Health Histories 313 13.2 Documenting Clinical, Radiographic, and Photographic Findings 315 13.3 Designing Prosthodontic Treatment Plans 320 13.4 Summary 338 References 340 14 Exam, Diagnosis and Treatment Planning in Pediatric Patients 343 14.1 The Complete History and Examination 343 14.2 Diagnosis 360 14.3 Treatment Planning 361 14.4 Risk Based, Age Appropriate Diagnosis and Treatment Planning 370 Recommended Textbooks and Additional Reading 384 References 384 15 Orthodontics for the General Practitioner 387 15.1 Introduction to Orthodontics 387 15.2 Diagnosis and Malocclusion Classification 388 15.3 Orthodontic Interventions Commonly Accomplished by the General Practitioner 399 15.4 Management of the Mixed Dentition 402 Recommended Resources and Textbooks 404 References 404 16 Putting It All Together 407 16.1 Rational Approach to Treatment Planning 407 16.2 Putting It All Together 410 16.3 Presentation of the Treatment Plan 411 16.4 Consultations and Referrals 412 16.5 Conclusion 413 Suggested Reading 414 Index 415
£81.65
Wiley Biomedical Image Analysis Recipes in MATLAB
Book SynopsisAs its title suggests, this innovative book has been written for life scientists needing to analyse their data sets, and programmers, wanting a better understanding of the types of experimental images life scientists investigate on a regular basis. Each chapter presents one self-contained biomedical experiment to be analysed. Part I of the book presents its two basic ingredients: essential concepts of image analysis and Matlab. In Part II, algorithms and techniques are shown as series of recipes or solved examples that show how specific techniques are applied to a biomedical experiments like Western Blots, Histology, Scratch Wound Assays and Fluoresence. Each recipe begins with simple techniques that gradually advance in complexity. Part III presents some advanced techniques for the generation of publication quality figures. The book does not assume any computational or mathematical expertise. A practical, clearly-written introduction to biomedical image analysis that provides the tools for life scientists and engineers to use when solving problems in their own laboratories. Presents the basic concepts of MATLAB software and uses it throughout to show how it can execute flexible and powerful image analysis programs tailored to the specific needs of the problem. Within the context of four biomedical cases, it shows algorithms and techniques as series of recipes, or solved examples that show how a particular technique is applied in a specific experiment. Companion website containing example datasets, MATLAB files and figures from the book. Table of ContentsPreface vii Acknowledgements ix About the Companion Website xi 1 The Basic Ingredients 1 1.1 The Matlab Environment 1 1.2 Introduction to Matlab 3 1.3 Operations with Matrices 7 1.4 Combining Matrices 10 1.5 Addressing a Matrix 13 1.6 Mathematical Functions and Graphical Display 17 1.7 Random Numbers 23 1.8 Statistics in Matlab 26 1.9 Displaying Two-Dimensional Matrices 29 1.10 Scripts Functions and Shortcuts 37 1.11 Using Help 43 2 Introduction to Images 45 2.1 An Image as a Matrix 45 2.2 Reading Images 46 2.3 Displaying Images 49 2.4 Colormap 54 2.5 Thresholding and Manipulating Values of Images 59 2.6 Converting Images into Doubles 68 2.7 Save Your Code and Data 69 3 Introduction to Colour 71 3.1 Mixing and Displaying Colours 71 4 Western Blots 79 4.1 Recipe 1: Many Ways to Display a Western Blot 80 4.2 Recipe 2: Investigating the Numbers That Make a Western Blot 93 4.3 Recipe 3: Image Histograms 97 4.4 Recipe 4: Transforming an Image of a Western Blot 104 4.5 Recipe 5: Quantification of the Data 111 4.6 Recipe 6: Investigating Position of Bands 121 5 Scratch Wound Assays 135 5.1 Analysis of Scratch Wound Assays 135 5.2 Recipe 1: Low Pass Filtering ScratchWound Assays in the Spatial Domain 139 5.3 Recipe 2: High Pass Filtering ScratchWound Assays in the Spatial Domain 143 5.4 Recipe 3: Combining Filters and Morphological Operations 154 5.5 Recipe 4: Sensitivy to Thresholds and Hysteresis Thresholding 161 5.6 Recipe 5: Morphological Operators 167 5.7 Recipe 6: Measuring Distances Between Cellular Boundaries 178 5.8 Recipe 7: Introduction to Fourier Analysis 187 5.9 Recipe 8: Filtering Scratch Wound Assays in the Fourier Domain 201 References 213 6 Bright Field Microscopy 215 6.1 Recipe 1: Changing the Brightness and Contrast of an Image 215 6.2 Recipe 2: Shading Correction: Estimation of Shading Component as a Plane 224 6.3 Recipe 3: Estimation of Shading Component with Filters Morphological Operators and Envelopes 235 6.4 Recipe 4: Mosaicking and Stitching 247 6.5 Recipe 5: Pixel Intensity and Histograms in Immunohistochemistry 261 6.6 Recipe 6: Hue-Saturation-Value 271 6.7 Recipe 7: Multidimensional Histograms 278 Reference 289 7 Fluorescence Microscopy 291 7.1 Recipe 1: Separating and Combining Colour Channels 294 7.2 Recipe 2: Investigating the Scaling of Values 298 7.3 Recipe 3: Automatic Threshold Selection 301 7.4 Recipe 4: Measuring Absolute and Relative Areas 304 7.5 Recipe 5: Counting Nuclei 305 7.6 Recipe 6: Quantification of Region Properties Beyond the Area 308 7.7 Recipe 7: Dividing an Image into Regions 310 7.8 Recipe 8: Batch Processing and Montages 316 7.9 Recipe 9: A Myriad of Measurements 327 References 341 8 Creating Publication-Quality Figures from Matlab 343 8.1 Recipe 1: Modifying the Characteristics of the Figures 344 8.2 Recipe 2: Numerous Plots in One Figure 352 8.3 Recipe 3: Three-Dimensional Ribbons with Different Annotations 362 8.4 Recipe 4: Three-Dimensional Graphics 378 8.5 Recipe 5: Projections 388 8.6 Recipe 6: Four-Dimensional Data Set Explored 391 Index 401
£69.30
John Wiley and Sons Ltd Atlas of Dermatopathology
Book SynopsisImprove your dermatological diagnostic accuracy. The most efficient method in the diagnosis of skin diseases is the combined validation of clinical and histopathological features. The results of biopsy investigation in isolation don't always yield answers. But when considered together, the clinical pattern and the histopathology, then diagnosis can become clearer. In this process the diagnostic impact of histopathology may be decisive or just confirmative to the clinical differential diagnosis. The structure of the book follows a basic approach to morphology, which is overall orientation at scanning magnification first, then identifying a prototypic pattern, and finally finding the essential diagnostic clue(s) under high power magnification. Dermatopathology: Practical Differential Diagnosis by Clinicopathologic Pattern provides top quality images to correlate clinical presentations with histopathologic features. Annotated images highlight subtle indicationTable of ContentsPreface ix Abbreviations xi Introduction xiii 1 Horny Layer 1 Reduced granular layer Prominent granular layer 2 Epidermis 15 Eczematous Acute Subacute Chronic Pruriginous Psoriasiform Bullous, acantholytic Pustular Degenerative Necrotic Ballooning Koilocytic Atrophic 3 Dermal–epidermal Junction (Interface) 109 Lichenoid Subepidermal blistering 4 Dermis 133 Edema Infiltrates Non-granulomatous Granulomatous Connective tissue Sclerosis Perforation and extrusion 5 Vessels 221 Intravascular coagulation Vasculitis Small vessel Medium-sized vessel Medium and large Localized Arteritis Vasculopathic changes 6 Subcutis 265 Panniculitis, septal Panniculitis, lobular Fat necrosis 7 Deposition and Storage 281 Foreign bodies Lipids Mucin Amyloid Calcium and bone 8 Adnexae 321 Pilosebaceous unit Hair Hair follicles not reduced Hair follicles reduced Index 351
£97.16
John Wiley and Sons Ltd TextAtlas of Skeletal Age Determination
Book SynopsisThe first complete textbook and atlas of the vitally important technique of bone age assessment utilizing MRI for children''s hand and wrist This latest volume in the growing Wiley Current Clinical Imaging series is a must-have resource that collects, in a single volume, all that is currently known and applicable about the use of magnetic resonance imaging (MRI) for the assessment of bone age. Presented in two parts, Text-Atlas of Skeletal Age Determination: MRI of the Hand and Wrist in Children first focuses on the anatomic, social, and legal aspects of bone age, providing a concise overview of the use of bone age determination in medical, legal, and social systems.??It then covers the clinical use and application of MRI in assessing bone age. The book offers complete chapter coverage on endocrinology, puberty, and disorders of pubertal development; bone marrow maturation in healthy and diseased states; growth failure and pediatric inflammatory bowel disease; sTable of ContentsContributors, ix Introduction, xiii Preface, xv 1 Anatomic Aspects of Bone Ossifi cation and their Magnetic Resonance Counterparts, 1Guido Carpino, Ernesto Tomei, Richard C. Semelka, and Eugenio Gaudio 2 Bone Age: Medico-legal Issues, 7Serenella Serinelli, Paolo Arbarello, Sofia Battisti, Ernesto Tomei, and Richard C. Semelka 3 Endocrinology, Puberty, and Disorders of Pubertal Development, 17Antonio Radicioni, Gilda Ruga, Sofia Battisti, Richard C. Semelka, Ernesto Tomei, and Andrea Lenzi 4 MR Assessment of Skeletal Age in Healthy Children, 23Ernesto Tomei, Sofia Battisti, Milvia Martino, and Richard C. Semelka 5 Maturation of Individual Bones of the Hand and Wrist in Healthy Children, 57Milvia Martino, Sofia Battisti, Richard C. Semelka, and Ernesto Tomei 6 Musculoskeletal Findings in Young Athletes, 77Sofia Battisti, Milvia Martino, Alessandro Sartori, Ernesto Tomei, and Richard C. Semelka 7 Bone Marrow Maturation in Healthy and Diseased States, 85Sofia Battisti, Ernesto Tomei, Antonello Rubini, Milvia Martino, Andrea Laghi, and Richard C. Semelka 8 Nutrition and Growth, 93Silvia Migliaccio, Sofia Battisti, Alessandro Pinto, Lorenzo Maria Donini, Ernesto Tomei, and Richard C. Semelka 9 MRI Skeletal Age Estimation in Celiac Disease, 99Monica Montuori, Maria Bavestrelli, Margherita Bonamico, Milvia Martino, Richard C. Semelka, and Ernesto Tomei 10 Growth Failure and Pediatric Infl ammatory Bowel Disease, 105Marina Aloi, Salvatore Cucchiara, Milvia Martino, Richard C. Semelka, and Ernesto Tomei 11 Adult Bone Diseases That Begin in Childhood, 109Salvatore Minisola, Vincenzo Carnevale, Najwa Al Ansari, Ernesto Tomei, and Richard C. Semelka 12 Skeletal Findings in Neurometabolic Disease, 117Mario Mastrangelo, Sara Bertino, Sofia Battisti, Richard C. Semelka, Ernesto Tomei, and Vincenzo Leuzzi 13 Skeletal Findings in Genetic Disease, 123Luigi Tarani, Natascia Liberati, Chiara Mancini, Francesca Mancini, Michela Martini, Chiara Mattiucci,Giovanni Parlapiano, Leonardo Pimpolari, Richard C. Semelka, and Fiorenza Colloridi 14 Skeletal Findings in Pediatric Oncology Patients, 133Anna Clerico, Giulia Varrasso, Carlo Alberto Cappelli, Milvia Martino, Richard C. Semelka, and Ernesto Tomei 15 Bone Mineral Density Measured with DXA Method in Pediatric Infl ammatory Bowel Diseases, 137Carlina V. Albanese and Richard C. Semelka 16 MRI of the Symptomatic Hand and Wrist, 143Daniel B. Nissman 17 Magnetic Resonance Imaging Principles and Techniques, 149Daniel B. Nissman and Brian M. Dale Index, 155 A color plate section falls between pages 144 and 145
£125.06
