Medical specialties, branches of medicine Books
Harvard University Press The Evolution of the Human Head
Book SynopsisExplains how the human head works, and why our heads evolved in this peculiarly human way. This book documents how the many components of the head function, how they evolved since we diverged from the apes, and how they interact in diverse ways both functionally and developmentally, causing them to be highly integrated.Trade ReviewLieberman's integrated approach will make his book a forum for a way of thinking in human evolution that has not yet found its equal in print. -- Christopher Dean, University College LondonThis is an outstanding book. Lieberman draws from a wide variety of disciplines, including bone biology, embryology, morphometrics, functional anatomy, and paleontology to forge a masterful synthesis of the evolution of the human head. It will be the definitive reference for decades. * John G. Fleagle, Department of Anatomical Sciences, Stony Brook University *Lieberman offers acute descriptions of anatomy, embryology, physiology, and hominid fossils, while providing an exciting way to observe the relationships among structures, functions, and evolutionary variance. -- Scott Vieira * Library Journal *Lieberman dives deep into the cranium, showing just how much of what we consider to be human is connected to what happens above the neck. -- Carolyn Y. Johnson * Boston Globe *Daniel Lieberman has written a wonderful and inspiring book about the human head's evolution...One stands in awe at the work that has gone into it...This encyclopedic book is transformative...The morphological details in Lieberman's book make it a direct descendant of Gray's Anatomy...If a single word describes this book, it is integrative. The author integrates material from anatomy, physiology, physics, biomechanics, molecular and developmental biology, but brings all under the umbrella of evolutionary theory. -- Chris McManus * Times Higher Education *This [is an] impressive book...This hefty and well-written book offers a scholarly breadth and attention to detail that are certainly laudable. The book is quite unusual in that it includes a comprehensive review of the soft tissues associated with cranial features and discusses them within the context of evolutionary morphology and the fossil record of the human skull. I can think of no other volume that packages the anatomy of the human head in this fashion...Lieberman's big book definitely moves us ahead in effectively synthesizing so much of what is currently understood about the structure, function and evolution of the human head. -- Brian T. Shea * American Scientist *By rooting his study in the basics of tissue mechanics and functional morphology, Lieberman does the spadework to which all such studies aspire but few achieve--and makes that task seem elegant and effortless. -- Henry Gee * Nature *Daniel Lieberman marshals diverse evidence to provide a comprehensive framework for understanding patterns of variation and covariation in the form, function, and phylogeny of the human head...The breadth and diversity of subject matter the volume will impart to the reader is particularly laudable. Lieberman's holistic approach is a welcome, if not requisite, strategy for addressing a multifarious biological system such as the human head. The book's focus on both hard- and soft-tissue components, consideration of how such elements correspond to one another, and comprehensive overview of external and internal influences on patterns of morphological variation and covariation clearly set the tone for how one might profitably investigate cranial evolution across all vertebrates. The introductions to myriad biological concepts, surveys of some modern approaches to outstanding paleoanthropological questions, and review of fossil evidence regarding evolutionary transformations in human skull form will enlighten readers of all backgrounds. The Evolution of the Human Head is an entertaining read...It contains a wealth of information relevant to human evolution. In doing so, it offers a wonderful entrée into many of the outstanding issues that will undoubtedly remain at the center of debates regarding human origins for years to come. -- Matthew J. Ravosa * Science *
£43.16
OUP USA Helping Children with Selective Mutism and Their Parents A Guide for SchoolBased Professionals
£28.77
John Wiley & Sons Inc Dictionary for Clinical Trials
Book SynopsisAs a result of the expansion in the area of pharmaceutical medicine there is an ever-increasing need for educational resources. The Dictionary of Clinical Trials, Second Edition comprehensively explains the 3000 words and short phrases commonly used when designing, running, analysing and reporting clinical trials.Trade Review"These succinct definitions effectively provide the researcher with a working understanding of the term, enabling one to understand the structure and outcomes of a clinical trial." (American Reference Books Annual, March 2008)Table of ContentsPreface to the Second Edition. Preface to the First Edition. The Ground Rules. Bibliography. A to Z entries. Appendix 1: ICH "Efficacy' Guidelines. Appendix 2: Pharmaceutical Forms (or Dosage Forms). Appendix 3: Routes of Administration.
£41.75
John Wiley & Sons Inc Introduction to Tissue Engineering
Book SynopsisCovering a progressive medical field, Tissue Engineering describes the innovative process of regenerating human cells to restore or establish normal function in defective organs.Table of ContentsPreface xiii Acknowledgments xv List of Abbreviations xvii Important Terminology and Concepts xxi 1 Introduction to Tissue Engineering 1 1.1 Introduction to Tissue Engineering, 2 1.2 Chronic Shortage of Donor Organs, 3 1.3 The Tissue Engineering Paradigm, 4 1.4 Definition of Tissue Engineering, 5 1.5 Process of Bioengineering 3D Artificial Tissue, 9 1.6 Design Principles for Tissue Engineering, 12 1.7 Building Blocks of Tissue Engineering, 14 1.8 Scientific and Technological Challenges, 15 1.9 Functional Assessment of Artificial Tissue, 16 1.10 Seminal Papers in Tissue Engineering, 18 1.11 Applications of 3D Artificial Tissue, 20 1.12 Two-Dimensional Versus Three-Dimensional Culture, 22 1.13 Integration of Core Technologies, 22 1.14 Growth of Tissue Engineering, 24 1.15 Disciplines in Tissue Engineering, 26 1.16 Tissue Engineering and Related Fields, 28 Summary, 33 Practice Questions, 34 References, 35 2 Cells for Tissue Engineering 40 2.1 Cells and Tissue Engineering, 41 2.2 Cell Structure and Function, 43 2.3 The Dynamic Extracellular Matrix, 47 2.4 Cell Signaling, 48 2.5 Cellular Junctions, 50 2.6 Mammalian Tissue and Artificial Tissue, 52 2.7 Cell Sourcing, 52 2.8 The Cell Transplantation Process, 55 2.9 Cells for Cell Transplantation, 58 2.10 Mode of Action of Cells During Cell Transplantation, 59 2.11 Cell Transplantation and Tissue Engineering, 60 2.12 The Cell Culture Process, 61 2.13 Applications of Monolayer 2D Cell Culture, 64 2.14 Cell Culture Versus Tissue Engineering, 65 2.15 Introduction to Stem Cell Engineering, 66 2.16 Human Embryonic Stem Cells, 70 2.17 Induced Pluripotent Stem Cells, 71 2.18 Adult Stem Cells, 72 Summary, 72 Practice Questions, 73 References, 74 3 Biomaterials for Tissue Engineering 84 3.1 Definition of Biomaterials, 85 3.2 Scheme for Biomaterial Development, 88 3.3 Historical Perspective on Biomaterials, 90 3.4 Tensile Properties, 92 3.5 Modulation of Tensile Properties, 95 3.6 Material Degradation, 97 3.7 Biocompatibility, 100 3.8 Biomimetic Biomaterial, 104 3.9 Classification of Biomaterials, 106 3.10 Biomaterial Platforms, 108 3.11 Smart Materials, 113 3.12 The Dynamic Extracellular Matrix, 114 3.13 Idealized Biomaterial, 116 Summary, 118 Practice Questions, 119 References, 121 4 Tissue Fabrication Technology 130 4.1 Introduction to Tissue Fabrication Technologies, 131 4.2 Self-Organization Technology, 133 4.3 Cell Sheet Engineering, 135 4.4 Scaffold-Based Tissue Fabrication, 137 4.5 Cell and Organ Printing, 140 4.6 Solid Freeform Fabrication, 142 4.7 Soft Lithography and Microfluidics, 143 4.8 Cell Patterning, 145 4.9 Idealized System to Support Tissue Fabrication, 148 Summary, 149 Practice Questions, 150 References, 151 5 Vascularization of Artificial Tissue 156 5.1 Introduction, 157 5.2 Seminal Publications in Angiogenesis Research, 159 5.3 Vascularization Defined, 160 5.4 Molecular Mechanism of Vasculogenesis, 161 5.5 Molecular Mechanism of Angiogenesis, 163 5.6 Molecular Mechanism of Arteriogenesis, 164 5.7 Therapeutic Angiogenesis, 166 5.8 Tissue Engineering and Vascularization, 167 5.9 Conceptual Framework for Vascularization During Artificial Tissue Formation, 169 5.10 In Vivo Models of Vascularization, 172 5.11 Idealized Vascularization Strategy for Tissue Engineering, 174 5.12 Flow Chart and Decision Making, 176 5.13 Biologically Replicated Vascularization Strategies, 179 5.14 Biologically Mediated Vascularization Strategies, 181 5.15 Biologically Inspired Vascularization Strategies, 184 Summary, 186 Practice Questions, 187 References, 188 6 Bioreactors for Tissue Engineering 193 6.1 Introduction to Bioreactors, 194 6.2 Bioreactors Defined, 195 6.3 Classification of Bioreactors, 197 6.4 Design Considerations, 200 6.5 Idealized Bioreactor System, 202 6.6 Bioreactors and Tissue Engineering, 205 6.7 Bioreactors for Mammalian Cell Culture, 207 6.8 Bioreactors for Scaffold Fabrication, 209 6.9 Bioreactors for Scaffold Cellularization, 212 6.10 Perfusion Systems, 215 6.11 Bioreactors for Stretch, 219 6.12 Electrical Stimulation, 221 Summary, 226 Practice Questions, 227 References, 230 7 Tracheal Tissue Engineering 237 7.1 Structure and Function of the Trachea, 238 7.2 Congenital Tracheal Stenosis, 240 7.3 Genetic Regulation of Tracheal Development, 241 7.4 Post Intubation and Post Tracheostomy Tracheal Stenosis, 243 7.5 Treatment Modalities for Tracheal Stenosis, 245 7.6 Design Considerations for Tracheal Tissue Engineering, 247 7.7 Process of Bioengineering Artificial Tracheas, 247 7.8 Tissue Engineering Models for Artificial Tracheas, 250 7.9 Tracheal Tissue Engineering—An Example of a Clinical Study, 253 7.10 Tracheal Tissue Engineering—A Second Example of a Clinical Study, 255 Summary, 258 Practice Questions, 258 References, 260 8 Bladder Tissue Engineering 265 8.1 Bladder Structure and Function, 266 8.2 Neurogenic Bladder Dysfunction, 267 8.3 Surgical Bladder Augmentation, 269 8.4 Development of the Urinary Bladder, 270 8.5 Design Considerations for Bladder Tissue Engineering, 270 8.6 Process of Bioengineering Artificial Bladders, 271 8.7 Cell Sheet Engineering for Bladder Tissue Engineering, 273 8.8 Small Intestinal Submucosa (SIS) for Bladder Tissue Engineering, 275 8.9 Plga as a Biomaterial for Bladder Tissue Engineering, 278 8.10 Acellular Grafts for Bladder Tissue Engineering, 280 8.11 Organ Models for Bladder Tissue Engineering, 283 8.12 Clinical Study for Bladder Tissue Engineering, 284 Summary, 285 Practice Questions, 286 References, 288 9 Liver Tissue Engineering 295 9.1 Structure and Function of the Liver, 296 9.2 Acute Liver Failure, 297 9.3 Liver Transplantation, 299 9.4 Liver Regeneration, 301 9.5 Liver Development, 302 9.6 Design Considerations for Liver Tissue Engineering, 303 9.7 Process of Bioengineering Artificial Liver Tissue, 303 9.8 Stem Cells for Liver Tissue Engineering, 305 9.9 Surface Patterning Technology for Liver Tissue Engineering, 307 9.10 Biomaterial Platforms for Liver Tissue Engineering, 309 9.11 Fabrication of 3D Artificial Liver Tissue, 309 9.12 Vascularization for Liver Tissue Engineering, 311 9.13 Bioreactors for Liver Tissue Engineering, 312 9.14 Spheroid Culture for Liver Tissue Engineering, 313 Summary, 314 Practice Questions, 315 References, 317 Index 323
£108.86
John Wiley and Sons Ltd The Nuts and Bolts of Cardiac Pacing
Book SynopsisWhile there are many excellent pacing and defibrillation books, they are nearly all written by physicians for physicians. The second edition of the successful The Nuts and Bolts of Cardiac Pacing has been thoroughly updated, reflecting the new challenges, issues, and devices that clinicians deal with. Written specifically for non-cardiologists in a lively, intelligent and easy to follow style, it emphasizes real-life clinical practice and practical tips, including illustrations from actual clinical settings. Each chapter concludes with a checklist of key points from each subject (Nuts and Bolts). New features to the second edition include: updated terminology and images reflecting new software developments information on new innovations and advanced features, such as ventricular intrinsic preference and AF suppression new features on the automatic atrial capture test and follow-up features new chapter covering clinical studies on the pTable of ContentsIntroduction. 1 The healthy heart. 2 The conduction system. 3 Indications for pacing. 4 The history of pacing. 5 Implantable device codes. 6 Pacemaker technology. 7 Lead technology. 8 Implant techniques. 9 Single-chamber pacing. 10 Dual-chamber pacing. 11 Basic paced ECG interpretation. 12 Rate-responsive pacing. 13 Special features. 14 Systematic follow-up. 15 Troubleshooting and diagnostics. 16 Advanced features. 17 Clinical trials on pacing. Appendix: A short guide to systematic pacemaker. follow-up. Glossary. Index
£55.05
John Wiley and Sons Ltd Advances in Integrative Dermatology
Book SynopsisAn authoritative overview of contemporary approaches to integrative skin health The popularity of integrative medical treatment of skin disorders has increased significantly in recent yearsrequiring practicing clinicians to keep pace with continuingdevelopments in dermatological research and methods.Advances in Integrative Dermatologyoffers a comprehensive survey of this dynamic field, providing up-to-date information on both preventative and therapeutic approaches to skin health. Combining clinical medicine with complimentary treatment plans, integrative dermatology provides an innovative perspective to individual patient care. This essential text explores new research in areas including the effects of stress and pollution on the skin, the importance of high-quality sleep, complementary methods of averting skin conditions, and more. Recognizing the impact skin disorders have on physiological, psychological, and emotional health, editors Katlein França and Torello Lotti illustrate kTable of ContentsAcknowledgements ix Foreword xi List of Contributors xiii 1 Advances in Integrative Dermatology: Modifying the Concepts from the Past to Change the Future of Dermatology 1Katlein França and Torello Lotti 2 Psycho‐Neuro‐Endocrine‐Immunology: A Psychobiological Concept 9Torello Lotti and Katlein França 3 Psychoneurocutaneous Medicine 25Mohammad Jafferany, Paul Pastolero, and Katlein França 4 Acne 33Bárbara R. Ferreira, José C. Cardoso, José P. Reis, and Américo Figueiredo 5 Rosacea 57Victor Gabriel Clatici and Cristiana Voicu 6 Seborrheic Dermatitis 71David E. Castillo, Ilana Gunczler, Katlein França, and Jonette Keri 7 Autoimmune Skin Disorders 89Francesca Satolli, Miriam Rovesti, and Claudio Feliciani 8 Vitiligo 103Serena Gianfaldoni and Torello Lotti 9 The Combined Approach to Atopic Dermatitis 119Christopher Bridgett, Peter Norén, and Richard Staughton 10 Psoriasis 131Uwe Wollina 11 Urticaria 145Li-Ping Zhao and Xing‐Hua Gao 12 Lichen Planus and Lichenoid Disorders 163Valeria Mateeva and Snejina Vassileva 13 Itch: An Integrative Approach 187Radomir Reszke and Jacek C. Szepietowski 14 Infections of the Skin 231Carmen Maria Salavastru, Adelina Maria Sendrea, Stefana Cretu, and George Sorin Tiplica 15 Nonmelanoma Skin Cancer 257Anagha Bangalore Kumar, Yasser Al-Qubaisy, and Katlein França 16 Melanoma 271Karls Raimonds 17 The Microbiome in Hair Disorders 289Andy Goren, Maja Kovacevic , John McCoy , Mirna Situm, Zeljana Bolanca , Andrija Stanimirovic, Rachita Dhurat, Jill Chitalia , Aseem Sharma, and Torello Lotti 18 Integrative Treatment for Chronic Wounds 295Evan Darwin, Alexandra R. Vaughn, and Hadar Lev‐Tov 19 Diet and Skin 321Veronica Di Nardo, Farah Daaboul, Catherine E. Amey, and Victoria Barygina 20 Supplements and Skin 345Veronica Di Nardo 21 Water and Dermatology 351Belma Türsen 22 Sleep and Skin 361Ladan Mostaghimi 23 Exercise and Skin 367Veronica Di Nardo, Aurelio Conte, Francesca Finelli, and Torello Lotti 24 Skin and Pollution 379Katerina Damevska, Suzana Nikolovska, Jana Kazandjieva, Bisera Kotevska Trifunova, and Georgeta Bocheva 25 Cosmeceuticals 393Jaishree Sharad 26 Botulinum Toxin: Cosmetic and Noncosmetic Dermatological Uses 413Jaishree Sharad 27 Ayurvedic Dermatology 457Anagha Bangalore Kumar, Sushmitha Grama Srinivasan, and Raghavendra Rao 28 Acupuncture 467Paolo Amori and Liguori Aldo 29 Moxibustion in Dermatology 477Ümit Türsen and Begüm Ünlü 30 Cupping Treatment in Dermatology 483Begüm Ünlü and Ümit Türsen 31 Biofeedback 487Jacopo Lotti 32 Meditation, Hypnosis, and Psychotherapy for Skin Disorders 503Philip D. Shenefelt 33 Dermatoethics and Dermatobioethics in Integrative Dermatology 513Reginaldo de França, Aparecida Porto França, and Katlein França Index 521
£125.96
Yale University Press A Brief Natural History of Civilization
Book SynopsisA compelling evolutionary narrative that reveals how human civilization follows the same ecological rules that shape all life on EarthTrade Review“Starting from ecological and evolutionary principles that transcend our own species, Mark Bertness offers a new perspective on the rise of human civilization.”—Judith Bronstein, editor of Mutualism“A Brief Natural History of Civilization uses the science of natural history to frame the peril and promise of our times.”—Paul Ewald, author of Plague Time: The New Germ Theory of Disease“Understanding the ‘big picture’ of the development and trajectory of human civilization is vital as a global society faces collapse. Bertness’ book provides a brilliant short course on what should be the central topic for public education today.”—Paul R. Ehrlich, author of Human Natures“A remarkable, far-ranging synthesis with something new and eye-opening on just about every page. Mark Bertness points to the powerful force of cooperation as our best hope.”—James Gustave Speth, author of America the Possible: Manifesto for a New Economy“Who am I? This book weaves a powerful argument that our sense of self and our culture is very tightly coupled to our sense of place in nature. A remarkable synthesis!”—Paul Dayton, Scripps Institution of Oceanography
£21.38
John Wiley and Sons Ltd Lishmans Organic Psychiatry
Book SynopsisThe third edition of the now-classic text Organic Psychiatry by William Alwyn Lishman should be a part of every neuropsychiatrist''s library. It should also serve as a reminder that neuropsychiatric training programs must continue to promote personal clinical instruction, in the spirit of Lishman''s prose, as a guiding bedside beacon to future practitioners. from a review of the third edition in Journal of Neuropsychiatry and Clinical Neurosciences Over the past 30 years, thousands of physicians have depended on Lishman''s Organic Psychiatry. Its authoritative and reliable clinical guidance was - and still is - beyond compare. The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations iTable of ContentsContributor List vi Foreword vii Preface to the First Edition ix Preface to the Fourth Edition xi Part 1 | Principles 1 Basic Concepts in Neuropsychiatry 3 2 Neuropsychology in Relation to Psychiatry 29 3 Clinical Assessment 103 Part 2 | Specific disorders 4 Head Injury 167 5 Cerebral Tumours 281 6 Epilepsy 309 7 Intracranial Infections 397 8 Cerebrovascular Disorders 473 9 Alzheimer’s Disease and Other Dementias (Including Pseudodementias) 543 10 Endocrine Diseases and Metabolic Disorders 617 11 Addictive and Toxic Disorders 689 12 Movement Disorders 745 13 Sleep Disorders 817 14 Other Disorders of the Nervous System 845 Index 907
£68.64
Nova Science Publishers Inc The Traditional Sakkiya Practice: A Public Health
Book SynopsisSakkiya is a Hausa word, which has its origin from the Hausa culture, and it means the act of using hot pointed metallic tip to puncture bodily swelling with the aim of achieving a curative effect. The Hausa culture is one of the three most popular cultures in Nigeria. The Hausas are predominantly located in the northwestern geopolitical zone of Nigeria, predominantly working as farmers. The majority of the Hausa people practice the Islamic religion. Encounters from the medical setting with cases of complications arising from failure of Sakkiya treatment, where some patients did not survive this treatment made investigation into this form of alternative medicine a paramount issue. In order to fill the void of information and literature on Sakkiya treatment, the authors embarked on a literature search and field studies resulting in this book. The authors found a lack of historical evidence concerning the old traditional Sakkiya practice, and therefore urge archaeologists, anthropologists, sociologists and historians to investigate into the historical evolution of Sakkiya practice in northern Nigeria.Kehinde Kanmodi, BDS, ACIPM, AISQEM is a dental surgeon, lecturer, multidisciplinary researcher, and manager affiliated with Cephas Health Research Initiative Inc, Ibadan (head office), Community Health Officers Training Programme, Usmanu Danfodiyo University Teaching Hospital, Sokoto, National Teachers Institute, Department of Political Science of the National Open University of Nigeria, Abuja, Nigerian Institute of Management, Abuja, Chartered Institute of Project Management, Lagos, and Dental Clinic, Kebbi Medical Centre, Kalgo, Nigeria.Joav Merrick, MD, MMedSci, DMSc, born and educated in Denmark is professor of pediatrics, child health and human development affiliated with the Division of Pediatrics, Hadassah Hebrew University Medical Center, Mt Scopus Campus, Jerusalem, Israel, Kentucky Childrens Hospital, University of Kentucky, Lexington, United States and professor of public health at the Center for Healthy Development, School of Public Health, Georgia State University, Atlanta, United States, the former medical director of the Division for Intellectual and Developmental Disabilities, Ministry of Social Affairs and Social Services, Jerusalem and the founder and director of the National Institute of Child Health and Human Development in Israel.
£62.04
Nova Science Publishers Inc Alternative Medicine Yearbook 2010
Book Synopsis
£212.99
Oxford University Press Oxford American Handbook of Clinical Medicine
Book SynopsisThe Oxford American Handbook of Clinical Medicine Second Edition provides portable and rapid guidance when assessing symptoms and medical conditions presenting in patients.Table of ContentsPreface ; Acknowledgments ; List of contributors ; Symbols and abbreviations ; 1 Thinking about medicine ; 2 Epidemiology ; 3 Clinical skills ; 4 Symptoms and signs ; 5 Cardiovascular medicine ; 6 Pulmonary medicine ; 7 Gastroenterology ; 8 Renal medicine ; 9 Endocrinology ; 10 Neurology ; 11 Rheumatology and musculoskeletal conditions ; 12 Oncology ; 13 Surgery ; 14 Infectious diseases (ID) ; 15 Hematology ; 16 Geriatric medicine ; 17 Biochemistry ; 18 Radiology ; 19 Practical procedures ; 20 Emergency Medicine ; Index 746
£64.60
A&g Wilshire, LLC FoodAssociated Autoimmunities
£90.25
Wiley Paediatric and Neonatal Critical Care Transport
Book SynopsisCovers the processes involved in transporting sick children and neonates. This book includes: principles of safe transport; transport physiology; the ambulance environment; equipment and monitoring; air transport of critically ill children; neonatal resuscitation and stabilization; and, paediatric resuscitation and stabilization.Table of ContentsContributors. Acknowledgements. Foreword. Principles of safe transport. Transport physiology. The ambulance environment. Equipment and monitoring. Air transport of critically ill children. Neonatal transport. Neonatal resuscitation. Paediatric resuscitation and stabilisation. Management of the airway. Management of the circulation. Trauma. Drugs. Special transport interventions. What to do when it all goes wrong. Drugs. Appendix 1: Typical retrival forms. Appendix 2: Essential equations and aide-mémores. Selected references and bibliography. Index
£41.75
Microbiology Nuts and Bolts Microbiology Nuts and Bolts
£26.99
Moussa Issa EM Academy FRCEM FINAL: CRITICAL APPRAISAL Made Easy
£41.80
Springer Nature Switzerland AG Management and Strategies for Wound Healing
£170.99
Elsevier Health Sciences GoalOriented Assessment of Lifeskills GOAL Paper
Book Synopsis
£64.41
Taylor & Francis Inc Rebuilding Communities Challenges for Group Work
Book SynopsisRebuilding Communities: Challenges for Group Work is a collection of research and information presented at the 18th Annual Symposium of the Association for the Advancement of Social Work with Groups. Social workers, students, educators, and practitioners will examine how group work can improve multicultural relations within the community. Through your use of the valuable suggestions in this book, you will discover new ways to help the poor in your community help themselves, while giving them a sense of power and self-esteem to help them battle racism, sexism, and shrinking economic opportunities. Through Rebuilding Communities, you will also discover a formula for global group work that will help you make a difference by applying your hometown skills to the global community. This valuable book discusses the need for you to combine energy with humility, offer assistance with the ability to listen, to intervene when necessary, and to comprehend diversity for successful and beneTable of ContentsContents About the Editors Contributors Preface Acknowledgments Introduction Section I: Keynote Speakers Chapter 1: Strengthening Communities Through Groups: A Multicultural Perspective Introduction Our Perspective on Community Empowerment and Multiculturalism Examples of Multicultural Empowerment in Groups Commitment Closing Chapter 2: Community Building and Social Group Work: A New Practice Paradigm for American Cities Community Building: What Is It? The Approach: How Does Community Building Work? Conclusion Chapter 3: From Local to Global: Groups at the Heart of the Community the Global Traveler in Group Work--An Example Asking the Question, “Why?” Intervention for Resistance Against Oppression Conclusion Section II: Invitationals Chapter 4: Towards a Community of Care: The Development of the Family Caregivers’ Support Network What Is Caregiving? Who Are the Caregivers? Why Care? Social Programs and Supports for Caregivers History of the Family Caregivers Support Network at the Self-Help Resource Centre Barriers to Funding Outcomes of the Project to Date Implementation of an Information and Referral Service for Caregivers Development of New Self-Help Groups for Caregivers Development of a Database of Community Resources for Caregivers Publication and Distribution of a Newsletter for Caregivers Educational Workshops for Caregivers Development of a Peer Support Service for Caregivers Development of a Caregiver-Driven Network Structure Implementation of New Outreach, Research, and Advocacy Initiatives for Caregivers Development of a Self-Help/Mutual Aid Group for Professionals Discussion Chapter 5: Some Important Areas of Group Work Expertise Group Workers Know About Democratic Processes Group Workers Know About Group Leadership Group
£45.59
Taylor & Francis Ltd Men, Women, Passion and Power: Gender Issues in
Book SynopsisThis completely revised edition of Men, Women, Passion and Power offers a new critique of conventional notions of masculinity and femininity. Contemporary psychoanalytic debates about sexuality are explored, revealing how the cultural idealisation of men is replicated in theory and clinical practice. Illustrated with use of detailed and vivid case material, this book demonstrates that it is only when the feminist perspective has been truly integrated into theory that the psychoanalytic project will realise its full radical potential. Subjects covered include: * The power of female sexuality * Race, class and sexuality * The fragility of male sexual identity * Envy between the sexes. Marie Maguire argues that examining these issues and gaining an awareness of how our assumptions are influenced by social inequalities can enrich the psychotherapeutic process and result in a more balanced psychological relation between the sexes. Men, Women, Passion and Power will be of great interest to psychotherapists, psychoanalytic practitioners and anyone with an interest in the integration of a feminist perspective into psychoanalytic theory.Trade ReviewIncorporating new discoveries about the body and neuropsychology - as well as recent insights about femininity, masculinity, racism, culture, class and bisexuality - Marie Maguire's second edition of Men, Women, Passion and Power very helpfully takes forward their implications for individual psychotherapy with women and men today. - Janet Sayers, Professor of Psychoanalytic Psychology, University of Kent and author of Boy CrazyTable of ContentsIntroduction. Part 1: Theories of Female and Male Sexuality. Sexual and Cross-cultural Controversy. From the Penis to the Womb: Male Sexuality. What Do Women Want? Part 2: Contemporary Debates in Clinical Practice. Are Men Really Fragile? The Power of Women's Sexuality. Gender in the Transference Relationship. False Memories of Sexual Abuse? Female and Male Perversions? Differing Desires. Conclusion: Feminism and Psychotherapy: An Agenda for the Future. Bibliography.
£99.75
The University of Chicago Press Becoming a Psychotherapist A Clinical Primer
Book Synopsis
£28.00
The University of Chicago Press Suffering Made Real
Book SynopsisA study of the first attempts to understand how radiation affected the survivors of the atomic bomb and subsequent generations of Japanese, this book argues that Cold War politics and cultural values shaped this research. Using varied sources, it examines how US science was socially constructed.
£30.40
Columbia University Press Mental Health in the War on Terror
Book SynopsisAn investigation into the unintended cultural and psychological consequences of our fight against terrorism.Trade ReviewVery few people are able to synthesize the disciplines of anthropology, mental health, cultural studies, political theory, religious studies, bioethics, and forensics in the way Neil Krishan Aggarwal does in this book. He offers a balanced and insightful account of the challenges of forensic psychiatry in assessing and managing terrorism suspects. -- Hamada Hamid, Yale University Using concrete clinical cases to anchor sophisticated and thought-provoking analysis, Aggarwal demonstrates that not only ethics but also the very nature of clinical knowledge and practice are at issue in the use, and especially misuse, of mental-health categories in the War on Terror. His book brings a new level of critical self-reflection to the psychology of terrorism. -- James W. Jones, author of Blood That Cries Out from the Earth: The Psychology of Religious Terrorism An indispensable and astute account of the insidious cultural manifestations emerging from the justifying framework that is the War on Terror. In light of the increasingly intolerable actions permissible through deference to notions of national security, Aggarwal's review of bioethics is crucial to understanding the evolution, through politicization, of approaches to mental health. Aggarwal's review of orientalist positions within psychotherapy literature, which underpin this creeping securitization of mental health, reinforces the impact of culturally laden views on Islam and Muslims. An essential read. -- Orla Lynch, Centre for the Study of Terrorism and Political Violence, University of St Andrews Aggarwal has written a theoretically sophisticated, multisided exploration of how the War on Terror and mental health are powerfully connected through the 'culture' of psychiatry, psychoanalysis, hospitals, courts, the military, and Islam. His argument is that science, religion, and moral experience are not just infiltrated with cultural meanings but come to create new cultural forms such as 'trauma,' forensic processes, and 'terrorism,' which in turn remake the world. An important achievement. -- Arthur Kleinman, Harvard University A clear and impassioned discussion of the presence of psychiatrists and mental-health knowledge practices in the micro-functioning of the War on Terror and the impact of each on the other. The book is a compelling portrayal of the way that medicine and its scientific languages and knowledge structures are able to move through and across political domains, being put to use to challenge and undo the very power structures they are meant to serve. Engaging, rigorous, and beautifully written. -- Sarah Pinto, Tufts University In this impressive and provocative volume, Aggarwal reveals many hidden failings of dominant social and political thought on radicalization and terrorism. Bioethics, arabic science, and symptoms in Guantanamo detainees are all debated to present an alternative, rounded, and compelling approach that includes medicine and cultural psychiatry as essential actors. -- Kamaldeep Bhui, Queen Mary University of London The questions it poses are valuable, difficult, and without easy answers - for clinicians, military leaders, or even civilians, all of whom must live with a medical culture deeply marked by the war on terror. Publishers Weekly Should be required reading for psychiatrists and mental health professionals interested in the psychology of Islamist terrorism... It is an exemplar of the manner in which the lens of transcultural psychiatry can clarify our perspective... Psychiatric ServicesTable of ContentsPreface Acknowledgments 1. Mental Health, Culture, and Power in the War on Terror 2. Bioethics and the Conduct of Mental Health Professionals in the War on Terror 3. The Meanings of Symptoms and Services for Guantanamo Detainees 4. Depictions of Arabs and Muslims in Psychodynamic Scholarship 5. Depictions of Suicide Bombers in the Mental Health Scholarship 6. Knowledge and Practice in War on Terror Deradicalization Programs Epilogue Notes References Index
£38.25
Yale University Press Madhouse A Tragic Tale of Megalomania and Modern
Book SynopsisConvinced that he had uncovered the single source of psychosis, Henry Cotton, superintendent of the Trenton State Hospital, New Jersey, launched a ruthless campaign to 'eliminate the perils of pus infection'. This book reconstructs a nightmarish, cautionary chapter in modern psychiatry when professionals failed to police themselves.Trade Review"'Scull writes an exemplary narrative - reminding us that today's respected clinician can still easily become tomorrow's mad scientist.' Michael Moorcock, Daily Telegraph 'Madhouse is fascinating. Scull's detection is impressive; it extends over years.' Hugh Freeman, Times Literary Supplement 'A brilliant piece of medical scholarship...' The Irish Times"
£19.99
John Wiley & Sons Inc Severe Dementia
Book SynopsisSevere Dementia is a clinical text giving clear guidance on the management of all forms of severe dementia. It covers diagnosis, reviews all therapeutic interventions and includes chapters on the ethical, legal and social aspects of care of these patients.Trade Review"This is an excellent book for those interested in the care of patients with sever dementia." (Doody's Health Services)Table of ContentsList of contributors. Introduction. PART 1: INTRODUCTORY. Chapter 1: Assessment and Diagnosis of Severe Dementia (Paul Newhouse and Joseph Lasek). Chapter 2: Neurochemistry of Severe Dementia (Sally I. Sharp, Paul T. Francis and Clive G. Ballard). Chapter 3: The Molecular Pathology of Severe Dementia (Clive Holmes). PART 2: CLINICAL FEATURES OF SEVERE DEMENTIA. Chapter 4: Cognitive Functions in Severe Dementia (Judith Saxton and François Boller). Chapter 5: Behavioural and Psychological Symptons of Dementia – Agitation (E. Jane Byrne and Deborah Collins). Chapter 6: Depression in Severe Dementia (Kate Bielinski and Brian Lawlor). Chapter 7: Physical Aspects of Severe Alzheimer’s Disease (Bruno Vellas). Chapter 8: Clinical Features of Severe Dementia: Staging (Barry Reisberg, Jerzy Wegiel, Emile Franssen, Sridhar Kadiyala, Stefanie Auer, Liduïn Souren, Marwan Sabbagh and James Golomb). Chapter 9: Clinical Features of Severe Dementia: Function (Serge Gauthier). PART 3: MANAGEMENT. Chapter 10: Drug Treatment: Memantine (Anton P. Porsteinsson and Pierre N. Tariot). Chapter 11: Drug Treatment: Cholinesterase Inhibitors (Michael Woodward and Howard Feldman). Chapter 12: Drug Treatment: Treatment of Behavioural and Psychological Symptoms of Dementia with Neuroleptics (Peter Paul De Deyn). Chapter 13: Non-pharmacological Treatment of Severe Dementia: An Overview (Ross Overshott and Alistair Burns). Chapter 14: Non-pharmacological Treatment of Severe Dementia: the Seattle Protocols (Rebecca G. Logsdon, Linda Teri and Sue M. McCurry). Chapter 15: Care by Families for Late Stage Dementia (Steven H. Zarit and Joseph E. Gaugler). Chapter 16: Person-centred Care for People with Severe Dementia (Murna Downs, Neil Small and Katherine Froggatt). Chapter 17: Palliative Care in Patients with Severe Dementia (Raymond Koopmans, H. Roeline W. Pasman and Jenny T. van der Steen). Chapter 18: Narrative Ethics and Ethical Narratives in Dementia (Clive Baldwin). Chapter 19: Health Economics of Severe Dementia (Anders Wimo and Bengt Winblad). Index.
£131.35
Wiley Laser Surface Treatment of BioImplant Materials
Book SynopsisThe biomaterials technology industry is already well established in the western world and is growing rapidly within Asian Pacific nations. It is often described as the 'next electronics industry', whilst the laser is described as a 'solution looking for a problem'.Table of ContentsAcknowledgements. Introduction. 1. Bioactivity and Biointegration of Orthopaedic and Dental Implants. 1.1. Introduction. 1.3. Biointegration of Orthopaedic and Dental Implants. 1.4. Controlling the Bone-Implant Interface. 2. Surface Modification of Biomaterials. 2.1. Introduction. 2.3. Metallic Implants. 2.4. Surface Modification of Biomaterials. 2.5. Laser Surface Modification of Biomaterials. 3. Wettability in Biomaterials Science and Modification Techniques. 3.1. Introduction. 3.2. Wettability, Adhesion and Bonding Theoretical Background. 3.3. Wettability in Biomaterial Science. 3.4. Current Methods of Wettability Modification. 3.5. Laser Wettability Characteristics Modification. 4. CO2 Laser Modification of the Wettability Characteristics of Magnesia Partially Stabilised Zirconia. 4.1. Introduction. 4.2. Experimental Procedures. 4.3. The Effects of CO2 Laser Radiation on Wettability Characteristics. 4.4. Surface Energy and its Component Parts. 4.5. Identification of the Predominant Mechanisms Active in Determining Wettability Characteristics. 4.6. The Role Played by Microstructures in Terms of Crystal Size and Phase in Effecting Surface Energy Changes. 4.7. Investigation of Wettability and Work Adhesion Using Physiological Liquids. 4.8. Summary. 5. In vitro Biocompatibility Evaluation of CO2 Laser Treated Magnesia Partially Stabilised Zirconia. 5.1. Introduction. 5.2. Sample Preparation. 5.3. Bone Like Apatite Formation. 5.4. Protein Adsorption. 5.5. Osteoblast Cell Response. 5.6. Predictions for Implantation in an in vivo Clinical Situation. 5.7. Summary. 6. The Effects of CO2 Laser Radiation on the Wettability Characteristics of a Titanium Alloy. 6.1. Introduction. 6.2. Experimental Procedures. 6.3. The Effects of CO2 Laser Radiation on Wettability Characteristics. 6.4. Surface Energy and its Component Analysis. 6.5. Identification of the Predominant Mechanisms Active in Determining Wettability Characteristics. 6.6. Investigation of Wettability and Work Adhesion Using Physiological Liquids. 6.7. Summary. 7. In vitro Biocompatibility Evaluation of CO2 Laser Treated Titanium Alloy. 7.1. Introduction. 7.2. Sample Preparation. 7.3. Bone Like Apatite Formation on Titanium Alloys. 7.4. Protein Adsorption. 7.5. Osteoblast Cell Adhesion. 7.6. Predictions for Implantation in an in vivo Clinical Situation. 7.7. Summary. 8. Enquiry into the Possible Generic Effects of the CO2 Laser Treatment on Bone Implant Biomaterials. 8.1. Introduction. 8.2. Ascertaining the Generic Effects of CO2 Laser Treatment on Bioinert Ceramics. 8.3. Ascertaining the Generic Effects of CO2 Laser Treatment on Metal Implants. 8.4. Summary. Conclusions. References. Index.
£117.85
John Wiley & Sons Inc Advanced Manufacturing Technology for Medical
Book SynopsisThis book covers a range of applications where advanced manufacturing technology can be applied to medical procedures. Early chapters look at the reverse engineering process, where patient data is converted into a machine-readable format to allow users to create system solutions to medical problems.Table of ContentsContributors xi 1 Rapid Prototyping for Medical Applications 1Ian Gibson 1.1 Overview 1 1.2 Workshop on Medical Applications for Reverse Engineering and Rapid Prototyping 2 1.3 Purpose of This Chapter (Overview) 31.4 Background on Rapid Prototyping 3 1.5 Stereolithography and Other Resin-type Systems 6 1.6 Fused Deposition Modelling and Selective Laser Sintering 7 1.7 Droplet/Binder Systems 9 1.8 Related Technology: Microsystems and Direct Metal Systems 10 1.9 File Preparation 11 1.10 Relationship with Other Technologies 12 1.11 Disadvantages with RP for Medical Applications 13 1.12 Summary 14 Bibliography 14 2 Role of Rapid Digital Manufacture in Planning and Implementation of Complex Medical Treatments 15Andrew M. Christensen and Stephen M. Humphries 2.1 Introduction 16 2.2 Primer on Medical Imaging 16 2.3 Surgical Planning 18 2.3.1 Virtual planning 18 2.3.2 Implementation of the plan 20 2.4 RDM in Medicine 22 2.4.1 RP-generated anatomical models 22 2.4.2 Custom treatment devices with ADM 26 2.5 The Future 28 2.6 Conclusion 29 References 29 3 Biomodelling 31P. D’Urso 3.1 Introduction 31 3.2 Surgical Applications of Real Virtuality 32 3.2.1 Cranio-maxillofacial biomodelling 33 3.2.1.1 Integration of biomodels with dental castings 34 3.2.1.2 Use of biomodels to shape maxillofacial implants 35 3.2.1.3 Use of biomodels to prefabricate templates and splints 35 3.2.1.4 Use of biomodels in restorative prosthetics 36 3.2.2 Use of real virtuality in customized cranio-maxillofacial prosthetics 36 3.2.2.1 Computer mirroring techniques for the generation of prostheses 38 3.2.2.2 Results of implantation 39 3.2.2.3 Advantages of prefabricated customized cranioplastic implants 39 3.2.3 Biomodel-guided stereotaxy 39 3.2.3.1 Development of stereotaxy 40 3.2.3.2 Development of biomodel-guided stereotactic surgery 40 3.2.3.3 Biomodel-guided stereotactic surgery with a template and markers 41 3.2.3.4 Biomodel-guided stereotactic surgery using the D’Urso frame 42 3.2.3.5 Utility of biomodel-guided stereotactic surgery 43 3.2.4 Vascular biomodelling 44 3.2.4.1 Biomodelling from CTA 44 3.2.4.2 Biomodelling from MRA 45 3.2.4.3 Clinical applications of vascular biomodels 45 3.2.4.4 Vascular biomodelling: technical note 46 3.2.5 Skull-base tumour surgery 46 3.2.6 Spinal surgery 48 3.2.6.1 Spinal biomodel stereotaxy 48 3.2.6.2 Technical considerations in spinal biomodelling 50 3.2.7 Orthopaedic biomodelling 50 3.3 Case Studies 51 References 55 4 Three-dimensional Data Capture and Processing 59W. Feng, Y. F. Zhang, Y. F. Wu and Y. S. Wong 4.1 Introduction 60 4.2 3D Medical Scan Process 61 4.2.1 3D scanning 61 4.2.1.1 Computed tomography imaging and its applications 61 4.2.1.2 Magnetic resonance imaging and its applications 63 4.2.1.3 Ultrasound imaging and its applications 64 4.2.1.4 3D laser scanning 65 4.2.2 3D reconstruction 65 4.3 RE and RP in Medical Application 67 4.3.1 Proposed method for RP model construction from scanned data 68 4.3.2 Reconstruction software 69 4.3.3 Accuracy issues 70 4.4 Applications of Medical Imaging 71 4.5 Case Study 72 4.5.1 Case study with CT/MR scanned data 72 4.5.2 Case studies for RE and RP 74 4.6 Conclusions 76 References 76 Bibliography 76 5 Software for Medical Data Transfer 79Ellen Dhoore 5.1 Introduction 79 5.2 Medical Imaging: from Medical Scanner to 3D Model 79 5.2.1 Introduction 79 5.2.2 Mimics® 80 5.2.2.1 Basic functionality of Mimics 80 5.2.2.2 Additional modules in Mimics 82 5.3 Computer Approach in Dental Implantology 92 5.3.1 Introduction 92 5.3.2 Virtual 3D planning environment: SimPlant® 92 5.3.3 Guide to accurate implant treatment: SurgiGuide® 93 5.3.3.1 General concept of SurgiGuide® 93 5.3.3.2 Different types of SurgiGuide® 94 5.3.3.3 Immediate SmileTM: temporary prosthesis for truly ‘immediate’ loading 100 5.4 Conclusions 102 Bibliography 103 6 BioBuild Software 105Robert Thompson, Dr Gian Lorenzetto and Dr Paul D'Urso 6.1 Introduction 105 6.2 BioBuild Paradigm 109 6.2.1 Importing a dataset 110 6.2.2 Volume reduction 112 6.2.3 Anatomical orientation confirmation 112 6.2.4 Volume inspection and intensity thresholding 112 6.2.4.1 Intensity thresholding 113 6.2.4.2 Display options 114 6.2.5 Volume editing 114 6.2.5.1 Connectivity options 115 6.2.5.2 Volume morphology 115 6.2.5.3 Region morphology 116 6.2.5.4 Volume algebra 116 6.2.5.5 Labels 117 6.2.5.6 Volume transformations 117 6.2.6 Image processing 118 6.2.7 Build orientation optimization 118 6.2.8 3D visualization 119 6.2.9 RP file generation 119 6.3 Future Enhancements 120 6.3.1 Direct volume rendering (DVR) 120 6.4 Conclusion 121 References 121 7 Generalized Artificial Finger Joint Design Process Employing Reverse Engineering 123I. Gibson and X. P. Wang 7.1 Introduction 123 7.1.1 Structure of a human finger joint 123 7.1.2 Rheumatoid arthritis disease 123 7.1.3 Finger joint replacement design 124 7.1.4 Requirements for new finger joint design 125 7.1.5 Research objectives 126 7.2 Supporting Literature 127 7.2.1 Previous prosthetic designs 127 7.2.2 More recent designs 128 7.2.3 Development of a new design 128 7.2.4 Need for a generalized finger joint prosthesis 129 7.3 Technological Supports for the Prosthesis Design 130 7.3.1 Reverse engineering 130 7.3.2 Comparison of different imaging techniques 131 7.3.3 Engineering and medical aspects 131 7.3.4 NURBS design theory 131 7.4 Proposed Methodology 132 7.4.1 Finger joint model preparation 132 7.4.2 Finger joint digitization 133 7.4.3 Surface reconstruction in paraform 135 7.4.4 Curve feature extraction 135 7.4.5 Database construction and surface generalization 135 7.4.6 Review of the procedure 136 7.5 Finger Joint Surface Modelling and Feature Extraction 136 7.5.1 Data acquisition of the bone samples 136 7.5.2 Finger joint surface reconstruction 137 7.5.3 NURBS curve and feature extraction 138 7.5.3.1 NURBS curve extraction from the PP head 138 7.5.3.2 NURBS curve feature extraction from the PP and MP base 141 7.5.3.3 Discussion on curve feature extraction 142 7.5.4 Automatic surface reconstruction and feature extraction 143 7.5.4.1 Automated identification of the bearing surface 143 7.5.4.2 Automated feature extraction 143 7.6 Database Construction and Surface Generalization 145 7.6.1 Finger joint database construction 145 7.6.1.1 Statistical dimension analysis 145 7.6.1.2 PP head geometrical features 150 7.6.2 Generalized finger joint surface reconstruction 155 7.7 Conclusions 159 Acknowledgements 161 References 161 8 Scaffold-based Tissue Engineering – Design and Fabrication of Matrices Using Solid Freeform Fabrication Techniques 163Dietmar W. Hutmacher 8.1 Background 164 8.2 Introduction 167 8.3 Systems Based on Laser and UV Light Sources 167 8.3.1 Stereolithography apparatus (SLA) 167 8.3.2 Selective laser sintering (SLS) 170 8.3.3 Laminated object manufacturing (LOM) 171 8.3.4 Solid ground curing (SGC) 171 8.4 Systems Based on Printing Technology 172 8.4.1 Three-dimensional printing (3DP) 172 8.5 Systems Based on Extrusion/Direct Writing 176 8.6 Indirect SFF 180 8.7 Robotic and Mechatronically Controlled Systems 182 8.8 Conclusions 185 References 186 9 Direct Fabrication of Custom Orthopedic Implants Using Electron Beam Melting Technology 191Ola L. A. Harrysson and Denis R. Cormier 9.1 Introduction 191 9.2 Literature Review 192 9.2.1 Custom joint replacement implants 192 9.2.2 Custom bone plates and implants 196 9.3 Electron Beam Melting Technology 199 9.4 Direct Fabrication of Titanium Orthopedic Implants 201 9.4.1 EBM fabrication of custom knee implants 201 9.4.2 EBM fabrication of custom bone plates 202 9.4.3 Direct fabrication of bone ingrowth surfaces 203 9.5 Summary and Conclusions 204 References 205 10 Modelling, Analysis and Fabrication of Below-knee Prosthetic Sockets Using Rapid Prototyping 207J. Y. H. Fuh, W. Feng and Y. S. Wong 10.1 Introduction 208 10.1.1 Process of making the below-knee artificial prosthesis 208 10.1.1.1 Shaping of the positive mould 208 10.1.1.2 Fabrication of the prosthesis 209 10.1.2 Modelling, analysis and fabrication 210 10.2 Computer-Facilitated Approach 211 10.2.1 CAD modelling 211 10.2.2 Finite element analysis (FEA) 213 10.2.2.1 Geometries 213 10.2.2.2 Boundary conditions 213 10.2.2.3 Loading conditions 213 10.2.2.4 Analysis 214 10.3 Experiments 215 10.4 Results and Discussions 216 10.5 Rapid Socket Manufacturing Machine (RSMM) 219 10.5.1 RSMM design considerations 220 10.5.1.1 File format 220 10.5.1.2 Nozzle 220 10.5.1.3 System accuracy 221 10.5.2 Overview of the RSMM 221 10.5.3 Clinical test 223 10.5.4 Future work 224 10.6 Conclusions 225 Acknowledgements 225 References 225 Bibliography 226 11 Future Development of Medical Applications for Advanced Manufacturing Technology 227Ian Gibson 11.1 Introduction 227 11.2 Scanning Technology 228 11.3 RP Technology 229 11.4 Direct Manufacture 230 11.5 Tissue Engineering 231 11.6 Business 232 Index 233
£107.06
John Wiley & Sons Inc Language and Social Disadvantage Theory into
Book SynopsisThis book critically analyses and reviews the development of language in direct relation to social disadvantage in the early years and beyond. Definitions and descriptions of social disadvantage are addressed and the wider aspects discussed.Trade Review"…a book for all teachers and parents." (The Guardian, December 2006) Table of ContentsList of contributors. Introduction. PART I. Chapter 1 Language and social disadvantage: the effects of socio-economic status on children’s language acquisition and use (Jane Ginsborg). Chapter 2 The interplay between language and cognition in typical and atypical development (Nicola Botting). Chapter 3 Literacy and numeracy (Ivy Doherty and Jenny Landells). Chapter 4 Childhood speech and language difficulties and later life chances (Judy Clegg). Chapter 5 Language and the development of social and emotional understanding (Marion Farmer). Chapter 6 Language, behaviour and social disadvantage (Helen Stringer and Judy Clegg). Chapter 7 Language and communication in young people with learning difficulties: stories of social disadvantage (Monica Bray). Chapter 8 The effects of intervention on the communication skills of socially disadvantaged children (James Law and Francis Harris). PART II: Research reports. Chapter 9 Interventions to promote language development in socially disadvantaged children – the devil may be in the detail (James Law). 9.1 Participation in Sure Start: lessons from language screening (Caroline Pickstone). 9.2 The ‘Teaching Children Talking’ project (Linda Hobbs). 9.3 The Talking Table (Marion Farmer and Fleur Griffiths). 9.4 Implementing effective oral language interventions in preschool settings: no simple solutions (Julie E. Dockrell, Morag Stuart and Diane King). 9.5 Working and learning together: an evaluation of a collaborative approach to intervention with student speech and language therapists and nursery staff (Jenny Leyden and Marcin Szczerbinkski). 9.6 Facilitating narrative and social skills in secondary school students with language and behaviour difficulties (Helen Stringer). 9.7 Enhancing language and communication in language impaired secondary school-aged children (Victoria Joffe). Afterword (Ann Locke). Index.
£52.20
John Wiley & Sons Inc Disasters and Mental Health
Book SynopsisOffers a comprehensive overview of clinical, epidemiological, psychobiological, psychosocial and service organization aspects of disaster psychiatry. This title takes a practical approach and includes a series of reports on significant experiences made in this field in various regions of the world.Trade Review"…will inform mental health care providers and epidemiologists, as well as those that study and plan disaster response worldwide." (E-STREAMS, April 2006) "Highly recommended to all physicians who practice within the realm of psychological medicine…recommended to Health Science libraries as a general reference text…" (Electric Review, November/December 2005) "This timely book will help us maximize what we are summoned to bear when disaster inevitably strikes next." (New England Journal of Medicine, August 25, 2005) "This book offers an excellent source of research in the area…vital for those who prepare prevention and response to local and international crises." (Doody's Health Services)Table of ContentsList of contributors. Preface (Lopez-Ibor et al). 1. What is a Disaster? (Lopez-Ibor). 2. Psychological and Psychopathological Consequences of Disasters (Fullerton and Ursano). 3. Psychiatric Morbidity following Disasters: Epidemiology, Risk and Protective Factors (McFarlane). 4. Reevaluating the Link between Disasters and Psychopathology (Yehuda and Bierer). 5. Psychological Interventions for People Exposed to Disasters (Benyakar and Collazo). 6. Organization of Mental Health Services for Disaster Victims (Crocq et al). Mental Health Consequences of Disasters: Research Reports. 7. The Experience of the Kobe Earthquake (Shinfuku). 8. The Experience of the Marmara Earthquake (Gokalp). 9. The Experience of the Athens Earthquake (Christodoulou et al) 10. The Experience of the Nairobi US Embassy Bombing (Njeng and Nyamai). 11. The Experience of the New York September 11 Terroristic Attack (DeLisi et al). 12. The Experience of the Chernobyl Nuclear Disaster (Havenaar and Bromet). 13. The Experience of the Bhopal Disaster (Murthy). 14. The Latin American and Caribbean Experience (Caldas de Ameida and Rodriguez). 15. The Israeli Experience (Shalev). 16. The Palestinian Experience (El Sarraj and Qouta). 17. The Experience of Bosnia-Herzegovina: Psychosocial Consequences of War Atrocities on Children (Husain). 18. The Serbian Experience (Lecic-Tosevski and Draganic-Gajic). 19. The Croatian Experience (Folnegovic Smalc).
£123.26
John Wiley & Sons Inc Quantitative Methods for Health Research
Book SynopsisQuantitative Research Methods for Health Professionals: A Practical Interactive Courseis a superb introduction to epidemiology, biostatistics, and research methodology for the whole health care community. Drawing examples from a wide range of health research, this practical handbook covers important contemporary health research methods such as survival analysis, Cox regression, and meta-analysis, the understanding of which go beyond introductory concepts. The book includes self-assessment exercises throughout to help students explore and reflect on their understanding and a clear distinction is made between a) knowledge and concepts that all students should ensure they understand and b) those that can be pursued by students who wish to do so. The authors incorporate a program of practical exercises in SPSS using a prepared data set that helps to consolidate the theory and develop skills and confidence in data handling, analysis and interpretation.Table of ContentsPreface. Acknowledgements. 1. Philosophy of science and introduction to epidemiology. Introduction and learning objectives. 1.1 Approaches to scientific research. 1.2 Formulating a research question. 1.3 Rates: incidence and prevalence. 1.4 Concepts of prevention. 1.5 Answers to self-assessment exercises. 2. Routine data sources and descriptive epidemiology. Introduction and learning objectives. 2.1 Routine collection of health information. 2.2 Descriptive epidemiology. 2.3 Information on the environment. 2.4 Displaying, describing and presenting data. 2.5 Summary of routinely available data. 2.6 Descriptive epidemiology in action. 2.7 Overview of epidemiological study designs. 2.8 Answers to self-assessment exercises. 3. Standardisation. Introduction and learning objectives. 3.1 Health inequalities in Merseyside. 3.2 Indirect standardisation: calculation of the standardised mortality ratio (SMR). 3.3 Direct standardisation. 3.4 Standardisation for factors other than age. 3.5 Answers to self-assessment exercises. 4. Surveys. Introduction and learning objectives. 4.1 Purpose and context. 4.2 Sampling methods. 4.3 The sampling frame. 4.4 Sampling error, confidence intervals and sample size . 4.5 Response. 4.6 Measurement. 4.7 Data types and presentation. 4.8 Answers to self-assessment exercises. 5. Cohort studies. Introduction and learning objectives. 5.1 Why do a cohort study?. 5.2 Obtaining the sample. 5.3 Measurement. 5.4 Follow-up. 5.5 Basic presentation and analysis of results. 5.6 How large should a cohort study be?. 5.7 Confounding. 5.8 Simple linear regression. 5.9 Introduction to multiple linear regression. 5.10 Answers to self-assessment exercises. 6. Case-control studies. Introduction and learning objectives. 6.1 Why do a case-control study?. 6.2 Key elements of study design. 6.3 Basic unmatched and matched analysis. 6.4 Sample size for a case-control study. 6.5 Confounding and logistic regression. 6.6 Answers to self-assessment exercises. 7. Intervention studies. Introduction and learning objectives. 7.1 Why do an intervention study?. 7.2 Key elements of intervention study design. 7.3 The analysis of intervention studies. 7.4 Testing more complex interventions. 7.5 How big should the trial be?. 7.6 Further aspects of intervention study design and analysis. 7.7 Answers to self-assessment exercises. 8. Life tables, survival analysis and Cox regression. Introduction and learning objectives. 8.1 Survival analysis. 8.2 Cox regression. 8.3 Current life tables. 8.4 Answers to self-assessment exercises. 9. Systematic reviews and meta analysis. Introduction and learning objectives. 9.1 The why and how of systematic reviews. 9.2 The methodology of meta-analysis. 9.3 Systematic reviews and meta-analyses of observational studies. 9.4 The Cochrane Collaboration. 9.5 Answers to self-assessment exercises. 10. Prevention strategies and evaluation of screening . Introduction and learning objectives. 10.1 Concepts of risk. 10.2 Strategies of prevention. 10.3 Evaluation of screening programmes. 10.4 Cohort and period effects. 10.5 Answers to self-assessment exercises. 11. Probability distributions, hypothesis testing and Bayesian methods. Introduction and learning objectives. 11.1 Probability distributions. 11.2 Data that do not ‘fit’ a probability distribution. 11.3 Hypothesis testing. 11.4 Choosing an appropriate hypothesis test. 11.5 Bayesian methods. 11.6 Answers to self-assessment exercises. Bibliography. Index.
£119.65
John Wiley & Sons Inc Persisting Speech Difficulties 3 Childrens Speech
Book SynopsisThis is the third book in the series Children's Speech and Literacy Difficulties and is based on research and practice with school-age children with persisting speech and associated difficulties. It focuses on the psycholinguistic nature of their difficulties, how to design intervention programmes, and how intervention outcomes might be measured.Table of ContentsForeword. Preface. Acknowledgements. Chapter 1: Persisting Speech Difficulties. Chapter 2: Theory, Therapy and Methodology. Chapter 3: Stimuli Design: Segments in Single Words. Chapter 4: Working on Segments in Single Words. Chapter 5: Stimuli Design: Consonant Clusters in Single Words. Chapter 6: Working on Consonant Clusters. Chapter 7: Stimuli Design: Connected Speech. Chapter 8: Working on Connected Speech. Chapter 9: Generalisation. Chapter 10: Linking with Literacy. Chapter 11: Intelligibility. Chapter 12: Evaluating Intervention Outcomes. Chapter 13: Service Delivery Issues. Chapter 14: Putting the Speech back into Speech Therapy. Appendix 1: Speech processing profile. Appendix 2: Updated List of Examples of Tests for Each Question in the Psycholinguistic. Assessment Framework. Appendix 3: Speech processing model. Appendix 4: Template for Journal Review. Appendix 5: Examples of Core Vocabulary used with a child with PSDs. Appendix 6: Sample minimal pair lists. Appendix 7: Pro-forma for describing therapy tasks. Appendix 8: Child interview questions. Glossary. References. Index.
£60.75
John Wiley & Sons Inc Handbook of Psychiatric Drugs
Book SynopsisThe Handbook of Psychiatric Drugs is a comprehensive, clear, concise and quick reference to psychiatric drug therapies, designed to guide the clinician on the selection and implementation of treatment for mental illness.Trade Review"...an excellent little book...small enough that busy clinicians can easily read it cover to cover." (Psychiatric Times, June 2007) "…a basic guide to drugs used to treat mental disorders…at a reasonable cost and in a handy format." (American Reference Books Annual, March 2007) "…a welcome addition…well-written, easy to use, and thorough in its coverage…psychiatry residents as well as practicing clinicians will find this a useful, quick referral source." (Doody's Health Services)Table of ContentsPreface. Acknowledgements. Disclaimer. 1 Antipsychotic Drugs. Introduction. Pharmacology. Chemistry. Mechanism of Action. Pharmacokinetics. Indications for Use of Antipsychotic Drugs. Drug Selection and Initiation of Treatment. Drug Selection for the Treatment of Schizophrenia. Effects of Antipsychotic Agents on Symptoms of Schizophrenia. Drug Selection for the Treatment of Bipolar Disorder. Drug Selection for the Treatment of Major Depression With Psychotic Features. Drug Selection for the Treatment of Delusional Disorder. Drug Selection for the Treatment of Delirium. Drug Selection for the Treatment of Psychosis and Agitation Associated with Dementia. Drug Selection for the Treatment of Mental Retardation and Developmental Disorders. Drug Selection for Huntington’s Disease and Tourette’s Disorder. Substance-induced Psychoses. Adverse Effects of Antipsychotics. Acute Extrapyramidal Side Effects (Dystonia, Parkinsonism, Akathisia). Tardive Dyskinesia and Other Tardive Syndromes. Neuroleptic Malignant Syndrome. Endocrine and Sexual Effects. Metabolic Effects. Cardiovascular Effects. Gastrointestinal Effects. Hepatic Effects. Hematological Effects. Other Side Effects. Drug Interactions and Antipsychotic Agents. Antipsychotic Medications and Pregnancy. Additional Reading. 2 Antidepressants. Introduction. Pharmacology. Mechanisms of Action. Pharmacokinetics. Indications for Use of Antidepressants. Panic Disorder (PD). Obsessive–Compulsive Disorder (OCD). Generalized Anxiety Disorder (GAD). Social Phobias and Posttraumatic Stress Disorder (PTSD). Bulimia. Anorexia Nervosa. Body Dysmorphic Disorder (BDD). Premenstrual Dysphoria (PMDD). Childhood Disorders. Other Psychiatric Disorders. Other Medical Conditions. Drug Selection and Initiation of Treatment for Major Depression. Special Considerations in the Selection of an Antidepressant. Initiation of Treatment. Therapeutic Drug Monitoring. Early, or Pre-response, Period. Response, or Acute Treatment, Period. Treatment of Partially Responsive and Nonresponsive Patients. Antidepressant Augmentation. Changing to a New Agent. Continuation and Maintenance Periods, and Discontinuation. Side Effects. Anticholinergic Effects. Autonomic Effects. Neurologic Effects. Weight Gain. Gastrointestinal Symptoms. Sexual Dysfunction. Cardiac Conduction. Suicide Risk. Allergic and Hematologic Effects. Other Effects. Central Serotonergic Syndrome. Monoamine Oxidase Inhibitors. Drug Interactions. Tricyclic Antidepressants. Pharmacokinetic Effects. Monoamine Oxidase Inhibitors. Serotonin Reuptake Inhibitors. Other Second-Generation Antidepressants. Third-Generation Antidepressants. Summary. Recommendations for the Use of Antidepressants. Additional Reading. 3 Mood Stabilizers. Introduction. Pharmacology. Chemistry. Mechanism of Action. Pharmacokinetics. Indications. Drug Selection and Initiation of Treatment. Acute Mania. Drug Selection. Relative Efficacy of Different Agents. Treatment Initiation and Dose Titration. Acute Depression. Drug Selection. Treatment Initiation and Dose Titration. Breakthrough Episodes. Maintenance. Rapid Cycling. Costs. Adverse Effects. Drug Interactions. Pregnancy. Summary. Additional Reading. 4 Anxiolytic Drugs. Introduction. A General Approach to Using Medication with Anxious Patients. Pharmacology. Antidepressants. Benzodiazepines. Buspirone. Beta-Blocker Medications. Anticonvulsants. Antipsychotics. Indications for Use. Antidepressants. Benzodiazepines. Buspirone. Beta-blocker Medications. Anticonvulsants. Antipsychotics. Augmentation/Adjuvant Treatments. Drug Selection, Dose, and Initiation of Treatment. Side Effects. Drug Interactions. Contraindications and Special Precautions. Summary. Additional Reading. 5 Sedative–Hypnotic Agents. Introduction. Diagnosis. Treatment Options. Non-prescription Agents. Prescription Medications. Pharmacology. Benzodiazepines. Chloral Hydrate. Zolpidem. Zaleplon. Eszopiclone. Ramelteon. Drug Selection. Other Prescription Hypnotics. Treatment Implementation. Adverse Effects. Benzodiazepines. Chloral Hydrate. Zolpidem. Zaleplon. Eszopiclone. Ramelteon. Drug Interactions and Special Precautions. Summary. Additional Reading. 6 Psychostimulants. Introduction. Pharmacology. Chemistry. Mechanism of Action. Pharmacokinetics. Indications and Contraindications. Drug Selection. Treatment Initiation and Dose Titration. Treatment Evaluation. Maintenance Treatment. Treatment Resistance. Effects of Treatment on Symptoms. ADHD in Adults. Alternative Preparations to the Standard Stimulant Medications. Narcolepsy. Other Indications. Costs. Adverse Effects. Drug Interactions. Summary. Additional Reading. 7 Cognitive Enhancers and Treatments for Alzheimer’s Disease. Introduction. Pharmacology. Mechanism of Action. Pharmacokinetics. Indications. Drug Selection. Treatment Initiation. Maintenance Treatment. Treatment Evaluation. Adverse Effects. Cholinesterase Inhibitors. Drug Interactions. Summary. Additional Reading. 8 Drugs for Treating Substance Abuse Disorders. Introduction. Syndromes Associated with Intoxication. Alcohol Intoxication. Sedative–Hypnotic Intoxication. Opiate Intoxication. Cocaine and Amphetamine Intoxication. Intoxication by LSD, Mescaline, MDMA (‘Ecstasy’), and Psilocybin. Phencyclidine Intoxication. Drug Treatment of Withdrawal Syndromes. Alcohol Withdrawal. Withdrawal from Sedative–Hypnotics. Withdrawal from Opiates. Management of Withdrawal in Patients with Multiple Dependencies. Agents to Aid Relapse Prevention. Medications for Alcohol Dependence. Medications for Cocaine Dependence. Medications for Opiate Dependence. Special Considerations. Drug Treatments for Nicotine Dependence. Pharmacotherapies for Substance Abusers with Additional Psychiatric Illness. Pharmacotherapy for Specific Psychiatric Disorders. Drug Interactions in Chemical Dependency. Additional Reading. Index.
£30.35
John Wiley & Sons Inc Textbook of Pharmacoepidemiology
Book SynopsisThe Textbook of Pharmacoepidemiology provides a streamlined text for evaluating the safety and effectiveness of medicines. It includes a brief introduction to pharmacoepidemiology as well as sections on data sources, methodology and applications. Each chapter includes key points, case studies and essential references.Trade Review"…a useful textbook for upper-level undergraduate, graduate, and postdoctoral fellows in pharmacy, medical, and public health programs." (The Annals of Pharmacotherapy, June 2007) "This is a major text with far-reaching impact…recommended for all courses in public health or pharmacology…" (Electric Review, March/April 2007)Table of ContentsList of Contributors. Preface. Acknowledgments. Acknowledgments from Pharmacoepidemiology, Fourth Edition. SECTION I INTRODUCTION TO PHARMACOEPIDEMIOLOGY. 1. What is Pharmacoepidemiology? (Brian L. Strom). 2. Study Designs Available for Pharmacoepidemiology Studies (Brian L. Strom). 3. Sample Size Considerations for Pharmacoepidemiology Studies (Brian L. Strom). 4. Basic Principles of Clinical Pharmacology Relevant to Pharmacoepidemiology Studies (Sean Hennessy). 5. When Should One Perform Pharmacoepidemiology Studies? (Brian L. Strom). 6. Views from Academia, Industry, and Regulatory Agencies (Leanne K. Madre, Robert M. Califf, Robert F. Reynolds, Peter Arlett, and Jane Moseley). SECTION II SOURCES OF PHARMACOEPIDEMIOLOGY DATA. 7. Spontaneous Reporting in the United States (Syed Rizwanuddin Ahmad, Norman S. Marks, and Roger A. Goetsch). 8. Global Drug Surveillance: The WHO Programme for International Drug Monitoring (I. Ralph Edwards, Sten Olsson, Marie Lindquist, and Bruce Hugman). 9. Case–Control Surveillance (Lynn Rosenberg, Patricia F. Coogan, and Julie R. Palmer). 10. Prescription-Event Monitoring (Saad A.W. Shakir). 11. Overview of Automated Databases in Pharmacoepidemiology (Brian L. Strom). 12. Examples of Automated Databases (Andy Stergachis, Kathleen W. Saunders, Robert L. Davis, Stephen E. Kimmel, Rita Schinnar, K. Arnold Chan, Deborah Shatin, Nigel S.B. Rawson, Sean Hennessy, Winanne Downey, MaryRose Stang, Patricia Beck, William Osei, Hubert G. Leufkens, Thomas M. MacDonald, and Joel M. Gelfand). 13. Other Approaches to Pharmacoepidemiology Studies (Brian L. Strom). 14. How Should One Perform Pharmacoepidemiology Studies? Choosing Among the Available Alternatives (Brian L. Strom). 15. Validity of Pharmacoepidemiologic Drug and Diagnosis Data (Suzanne L. West, Brian L. Strom, and Charles Poole). SECTION III SPECIAL ISSUES IN PHARMACOEPIDEMIOLOGY METHODOLOGY. 16. Bias and Confounding in Pharmacoepidemiology (Ilona Csizmadi and Jean-Paul Collet). 17. Determining Causation from Case Reports (Judith K. Jones). 18. Molecular Pharmacoepidemiology (Stephen E. Kimmel). 19. Bioethical Issues in Pharmacoepidemiologic Research (Kevin Haynes, Jason Karlawish, and Elizabeth B. Andrews). 20. The Use of Randomized Controlled Trials for Pharmacoepidemiology Studies (Samuel M. Lesko and Allen A. Mitchell). 21. The Use of Pharmacoepidemiology to Study Beneficial Drug Effects (Brian L. Strom). 22. Pharmacoeconomics: Economic Evaluation of Pharmaceuticals (Kevin A. Schulman, Henry A. Glick, and Daniel Polsky). 23. Using Quality-of-Life Measurements in Pharmacoepidemiologic Research (Holger Schünemann, Gordon H. Guyatt, and Roman Jaeschke). 24. The Use of Meta-analysis in Pharmacoepidemiology (Carin J. Kim and Jesse A. Berlin). 25. Patient Adherence to Prescribed Drug Dosing Regimens in Ambulatory Pharmacotherapy (John Urquhart and Bernard Vrijens). 26. Novel Approaches to Pharmacoepidemiology Study Design and Statistical Analysis (Samy Suissa). SECTION IV SPECIAL APPLICATIONS OF PHARMACOEPIDEMIOLOGY. 27. Special Applications of Pharmacoepidemiology (David Lee, Sumit R. Majumdar, Helene Levens Lipton, Stephen B. Soumerai, Sean Hennessy, Robert L. Davis, Robert T. Chen, Roselie A. Bright, Allen A. Mitchell, David J. Graham, David W. Bates, and Brian L. Strom). 28. The Future of Pharmacoepidemiology (Brian L. Strom and Stephen E. Kimmel). Appendix A Sample Size Tables. Appendix B Glossary. Index.
£129.56
John Wiley & Sons Inc Hughes Outline of Modern Psychiatry
Book SynopsisHughes' Outline of Psychiatry, Fifth Edition presents a comprehensive account of current practice in psychiatry, summarising up-to-date knowledge of the subject in a concise way. Part I touches on general classification, causes and prevention of mental disorders.Table of ContentsPreface. PART I: THE NATURE AND ASSESSMENT OF PSYCHIATRIC DISORDER. 1 Classification. The basis of classification. Reliability and validity. Limitations and problems of classification. Common terms in psychiatric classification. Classification systems. 2 Causes and Prevention. Causation in clinical practice. Historical background. Genetics. Neurochemistry. Neuroradiology. Epidemiology. Individual life experience. Prevention of psychiatric disorder. 3 Assessment. Circumstances of referral. The psychiatric interview. Mental state examination. Physical examination. Structured interviews and questionnaires. Further assessments. Physical investigations. PART II: CLINICAL SYNDROMES. 4 Schizophrenia. Definition. Frequency. Epidemiology. Causation. Clinical features. Clinical types. Diagnostic criteria. Differential diagnosis. Treatment. Prognosis. 5 Mood Disorders: Depressive Illness and Mania. Frequency. Epidemiology. Causes. Clinical features of depressive illness. Types of depressive illness. Diagnosis of depressive illness. Clinical features of mania. Differential diagnosis of mood disorders. Treatment of depressive illness. Treatment of mania. Prophylaxis of affective disorder. 6 Anxiety and Stress-Related Disorders. Boundaries of anxiety disorder. Hierarchy of diagnosis. Frequency. Epidemiology. Causes. Clinical features. Differential diagnosis. Treatment. Prognosis. Generalized anxiety disorder (anxiety state). Panic disorder. Agoraphobia. Social phobia. Simple phobias (specific phobias, monophobias). Obsessive-compulsive disorders. Conversion and dissociative disorders. Post-traumatic stress disorder (PTSD). Adjustment disorders. Bereavement. 7 Personality Disorders. Definition. Classification. Types of personality disorder. Epidemiology. Differential diagnosis. Treatment. Prognosis. Sociopathic (dissocial) personality disorder. 8 Paranoid States. Definition. Predisposing factors. Differential diagnosis of paranoid states. Management. Culture-bound syndromes. 9 Physical Symptoms and Psychiatric Disorder. Introduction. Assessing physical symptoms in psychiatric practice. Unexplainedphysical symptoms. Management. Malingering and exaggeration. 10 Organic Brain Syndromes. Causes. Clinical features. Delirium. Dementia. Focal brain damage. 11 Liaison Psychiatry. Psychological influences on the course of physical disease. The stresses of physical illness. Adjustment and coping. Clinical depression in medically ill patients. Management and prevention. Liaison psychiatry. 12 Drug Misuse. Definitions. Epidemiology. Causes. Psychiatric and physical complications. Legal aspects. Pharmacology. Prevention. Treatment. Opiates. Amphetamines (speed). Cocaine and crack. Cannabis (Indian hemp, hashish, pot). Lysergic acid diethylamide (LSD, acid). MDMA (Ecstasy). Glues and solvents. Tobacco. Caffeine. Barbiturates. Benzodiazepines. 13 Alcohol Misuse. Safe limits of drinking. Frequency. Epidemiology. Causes. Effects of alcohol. Course of alcohol abuse. Recognition. Treatment. Prognosis. Prevention. 14 Deliberate Self-Harm. Suicide. Non-fatal deliberate self-harm (parasuicide, attempted suicide). 15 Eating Disorders: Anorexia Nervosa and Bulimia Nervosa. Introduction. Anorexia nervosa. Bulimia nervosa. Obesity. 16 Disorders of Female Reproductive Life. Pregnancy. Puerperal psychosis. Post-natal depression and other neurotic syndromes. Abortion. Stillbirth and perinatal death. Premenstrual syndrome. The menopause. Hysterectomy. 17 Sexual Problems. Sexual dysfunctions. Sexual deviations. Gender-identity disorders. Homosexuality. 18 Child and Adolescent Psychiatry. Predisposing factors. Classification. History taking and examination. Treatment. Relationship with adult disorder. Neurotic (emotional) disorders. Conduct disorders. Attention deficit disorder. Psychoses. Delays in development. Symptomatic disorders. Child abuse. Psychiatry of adolescence. 19 Learning disability. Frequency. Causes. Diagnosis of learning disability. Associated phenomena. Management. Prognosis. Prevention. Chromosomal abnormalities. Gene abnormalities. Acquired handicap. Miscellaneous. 20 Psychiatry of Old Age. Frequency. Clinical syndromes. Assessment. Specific treatments. Organization of services. 21 Forensic Psychiatry. Offending behaviour. Predicting violence and dangerousness. Psychiatric aspects of specific offences. Treatment: general considerations. Facilities for mentally disordered offenders. Psychiatric reports: criminal. PART III: TREATMENT. 22 Psychological Treatment. Historical background. Principles of psychotherapy today. Counselling. Cognitive-behavioural therapy (CBT). Psychodynamic psychotherapy. Group therapy. Family and marital therapy. Recent advances. 23 Psychopharmacology. General principles of using psychotropic drugs. Antipsychotics. Antidepressants. Antidepressants: tricyclic group. Antidepressants: SSRI group. Antidepressants: MAOI group. Other antidepressant drugs. Benzodiazepines. Mood stabilizers. Lithium. 24 Electroconvulsive Therapy (ECT) and Psychosurgery. Indications. Mode of action. Efficacy and prediction of response. Timing and number of treatments. Practicalities of treatment. Contraindications. Bilateral versus unilateral ECT. Unwanted effects. Consent for ECT. Myths. For the future. Psychosurgery. 25 Organization of Services. Introduction . Background and history. Community care. The psychiatric multidisciplinary team. Psychiatry in primary care. Inpatient services. Outpatient clinics. Crisis and home treatment. Day hospitals. Resource centres and day centres. Recovery and rehabilitation. The care programme approach. Assertive outreach teams. Non-NHS health-care facilities. 26 The Mental Health Act 1983. Introduction. Background. Compulsory admission. Patients already in hospital. Patients in the community. Relatives. Approved social workers (ASWs). Police powers. Mentally abnormal offenders. Consent to treatment. Information for detained patients. Mental Health Act Commission. Glossary. Index.
£46.95
John Wiley & Sons Inc Handbook of Neural Engineering
Book SynopsisThe Handbook of Neural Engineering provides the theoretical foundations and current applications from the leading researchers in this emerging new field. It focuses on the brain-computer interface, nano-neural engineering, neural prostheses, imaging the brain, neural signal processing, the brain and neurons.Trade Review"This handbook is an excellent and informative technical reference for researchers and undergraduate students with a basic background in electrical or biomedical engineering." (IEEE Engineering in Medicine and Biology Magazine, January/February 2009) "…a comprehensive summary of the latest trends and is an essential resource for researchers in this field." (Journal of the American Medical Association, August 22/29, 2007) "…very useful…for those already working in the discipline. It fills a void in the pertinent literature; there are few works that compare." (Doody's Book Reviews) "This is a good quality book…useful as a current survey and resource for ideas, and the state of the art." (Doody's Book Reviews) "...useful as a current survey and resource for ideas, and the state of the art." (Doody's Health Services)Table of ContentsPREFACE. CONTRIBUTORS. PART I: NEURAL SIGNAL AND IMAGE PROCESSING AND MODELING. CHAPTER 1: OPTIMAL SIGNAL PROCESSING FOR BRAIN–MACHINE INTERFACES (Justin C. Sanchez and Jose C. Principe). CHAPTER 2: MODULATION OF ELECTROPHYSIOLOGICAL ACTIVITY IN NEURAL NETWORKS: TOWARD A BIOARTIFICIAL LIVING SYSTEM (Laura Bonzano, Alessandro Vato, Michela Chiappalone, and Sergio Martinoia). CHAPTER 3: ESTIMATION OF POSTERIOR PROBABILITIES WITH NEURAL NETWORKS: APPLICATION TO MICROCALCIFICATION DETECTION IN BREAST CANCER DIAGNOSIS (Juan Ignacio Arribas, Jesús Cid-Sueiro, and Carlos Alberola-López). CHAPTER 4: IDENTIFICATION OF CENTRAL AUDITORY PROCESSING DISORDERS BY BINAURALLY EVOKED BRAINSTEM RESPONSES (Daniel J. Strauss, Wolfgang Delb, and Peter K. Plinkert). CHAPTER 5: FUNCTIONAL CHARACTERIZATION OF ADAPTIVE VISUAL ENCODING (Nicholas A. Lesica and Garrett B. Stanley). CHAPTER 6: DECONVOLUTION OF OVERLAPPING AUDITORY BRAINSTEM RESPONSES OBTAINED AT HIGH STIMULUS RATES (O. Ozdamar, R. E. Delgado, E. Yavuz, and N. Acikgoz). CHAPTER 7: AUTONOMIC CARDIAC MODULATION AT SINOATRIAL AND ATRIOVENTRICULAR NODES: OBSERVATIONS AND MODELS (S. Ward, R. Shouldice, C. Heneghan, P. Nolan, and G. McDarby). CHAPTER 8: NEURAL NETWORKS AND TIME–FREQUENCY ANALYSIS OF SURFACE ELECTROMYOGRAPHIC SIGNALS FOR MUSCLE CEREBRAL CONTROL (Bruno Azzerboni, Maurizio Ipsale, Fabio La Foresta, and Francesco Carlo Morabito). CHAPTER 9: MULTIRESOLUTION FRACTAL ANALYSIS OF MEDICAL IMAGES (Khan M. Iftekharuddin and Carlos Parra). CHAPTER 10: METHODS FOR NEURAL-NETWORK-BASED SEGMENTATION OF MAGNETIC RESONANCE IMAGES (Lia Morra, Silvia Delsanto, and Fabrizio Lamberti). CHAPTER 11: HIGH-RESOLUTION EEG AND ESTIMATION OF CORTICAL ACTIVITY FOR BRAIN–COMPUTER INTERFACE APPLICATIONS (F. Cincotti, M. Mattiocco, D. Mattia, F. Babiloni, and L. Astolfi) CHAPTER 12: ESTIMATION OF CORTICAL SOURCES RELATED TO SHORT-TERM MEMORY IN HUMANS WITH HIGHRESOLUTION EEG RECORDINGS AND STATISTICAL PROBABILITY MAPPING (L. Astolfi, D. Mattia, F. Babiloni, and F. Cincotti). CHAPTER 13: EXPLORING SEMANTIC MEMORY AREAS BY FUNCTIONAL MRI (G. Rizzo, P. Vitali, G. Baselli, M. Tettamanti, P. Scifo, S. Cerutti, D. Perani, and F. Fazio). PART II: NEURO–NANOTECHNOLOGY: ARTIFICIAL IMPLANTS AND NEURAL PROTHESES. CHAPTER 14: RESTORATION OF MOVEMENT BY IMPLANTABLE NEURAL MOTOR PROSTHESES (Thomas Sinkjær and Dejan B. Popovic). CHAPTER 15: HYBRID OLFACTORY BIOSENSOR USING MULTICHANNEL ELECTROANTENNOGRAM: DESIGN AND APPLICATION (John R. Hetling, Andrew J. Myrick, Kye-Chung Park, and Thomas C. Baker). CHAPTER 16: RECONFIGURABLE RETINA-LIKE PREPROCESSING PLATFORM FOR CORTICAL VISUAL NEUROPROSTHESES (Samuel Romero, Francisco J. Pelayo, Christian A. Morillas, Antonio Martı´nez, and Eduardo Ferna´ndez). CHAPTER 17: BIOMIMETIC INTEGRATION OF NEURAL AND ACOUSTIC SIGNAL PROCESSING (Rolf Müller and Herbert Peremans). CHAPTER 18: RETINAL IMAGE AND PHOSPHENE IMAGE: AN ANALOGY (Luke E. Hallum, Spencer C. Chen, Gregg J. Suaning, and Nigel H. Lovell). CHAPTER 19: BRAIN-IMPLANTABLE BIOMIMETIC ELECTRONICS AS NEURAL PROSTHESES TO RESTORE LOST COGNITIVE FUNCTION (Theodore W. Berger, Ashish Ahuja, Spiros H. Courellis, Gopal Erinjippurath, Ghassan Gholmieh, John J. Granacki, Min Chi Hsaio, Jeff LaCoss, Vasilis Z. Marmarelis, Patrick Nasiatka, Vijay Srinivasan, Dong Song, Armand R. Tanguay, Jr., and Jack Wills). CHAPTER 20: ADVANCES IN RETINAL NEUROPROSTHETICS (Nigel H. Lovell, Luke E. Hallum, Spencer C. Chen, Socrates Dokos, Philip Byrnes-Preston, Rylie Green, Laura Poole-Warren, Torsten Lehmann, and Gregg J. Suaning). CHAPTER 21: TOWARDS A CULTURED NEURAL PROBE: PATTERNING OF NETWORKS AND THEIR ELECTRICAL ACTIVITY (W. L. C. Rutten, T. G. Ruardij, E. Marani, and B. H. Roelofsen). CHAPTER 22: SPIKE SUPERPOSITION RESOLUTION IN MULTICHANNEL EXTRACELLULAR NEURAL RECORDINGS: A NOVEL APPROACH (Karim Oweiss and David Anderson). CHAPTER 23: TOWARD A BUTTON-SIZED 1024-SITE WIRELESS CORTICAL MICROSTIMULATING ARRAY (Maysam Ghovanloo and Khalil Najafi). CHAPTER 24: PRACTICAL CONSIDERATIONS IN RETINAL NEUROPROSTHESIS DESIGN (Gregg J. Suaning, Luke E. Hallum, Spencer Chen, Philip Preston, Socrates Dokos, and Nigel H. Lovell). PART III: NEUROROBOTICS AND NEURAL REHABILATION ENGINEERING. CHAPTER 25: INTERFACING NEURAL AND ARTIFICIAL SYSTEMS: FROM NEUROENGINEERING TO NEUROROBOTICS (P. Dario, C. Laschi, A. Menciassi, E. Guglielmelli, M. C. Carrozza, and S. Micera). CHAPTER 26: NEUROCONTROLLER FOR ROBOT ARMS BASED ON BIOLOGICALLY INSPIRED VISUOMOTOR COORDINATION NEURAL MODELS (E. Guglielmelli, G. Asuni, F. Leoni, A. Starita, and P. Dario). CHAPTER 27: MUSCLE SYNERGIES FOR MOTOR CONTROL (Andrea d’Avella and Matthew Tresch). CHAPTER 28: ROBOTS WITH NEURAL BUILDING BLOCKS (Henrik Hautop Lund and Jacob Nielsen) CHAPTER 29: DECODING SENSORY STIMULI FROM POPULATIONS OF NEURONS: METHODS FOR LONG-TERM LONGITUDINAL STUDIES (Guglielmo Foffani, Banu Tutunculer, Steven C. Leiser, and Karen A. Moxon) CHAPTER 30: MODEL OF MAMMALIAN VISUAL SYSTEM WITH OPTICAL LOGIC CELLS (J. A. Mart&ıacute;n-Pereda and A. González Marcos). CHAPTER 31: CNS REORGANIZATION DURING SENSORY-SUPPORTED TREADMILL TRAINING (I. Cikajlo, Z. Matjačić, and T. Bajd). CHAPTER 32: INDEPENDENT COMPONENT ANALYSIS OF SURFACE EMG FOR DETECTION OF SINGLE MOTONEURONS FIRING IN VOLUNTARY ISOMETRIC CONTRACTION (Gonzalo A. Garc&ıacute;a, Ryuhei Okuno, and Kenzo Akazawa). CHAPTER 33: RECENT ADVANCES IN COMPOSITE AEP/EEG INDICES FOR ESTIMATING HYPNOTIC DEPTH DURING GENERAL ANESTHESIA? (Erik Weber Jensen, Pablo Martinez, Hector Litvan, Hugo Vereecke, Bernardo Rodriguez, and Michel M. R. F. Struys). CHAPTER 34: ENG RECORDING AMPLIFIER CONFIGURATIONS FOR TRIPOLAR CUFF ELECTRODES (I. F. Triantis, A. Demosthenous, M. S. Rahal, and N. Donaldson). CHAPTER 35: CABLE EQUATION MODEL FOR MYELINATED NERVE FIBER (P. D. Einziger, L. M. Livshitz, and J. Mizrahi). CHAPTER 36: BAYESIAN NETWORKS FOR MODELING CORTICAL INTEGRATION Paul Sajda, Kyungim Baek and Leif Finkel). CHAPTER 37: NORMAL AND ABNORMAL AUDITORY INFORMATION PROCESSING REVEALED BY NONSTATIONARY SIGNAL ANALYSIS OF EEG (Ben H. Jansen, Anant Hegde, Jacob Ruben, and Nashaat N. Boutros). CHAPTER 38: PROBING OSCILLATORY VISUAL DYNAMICS AT THE PERCEPTUAL LEVEL (H. Fotowat, H. Ö&gcaron;men, H. E. Bedell, and B. G. Breitmeyer). CHAPTER 39: NONLINEAR APPROACHES TO LEARNING AND MEMORY (Klaus Lehnertz). CHAPTER 40: SINGLE-TRIAL ANALYSIS OF EEG FOR ENABLING COGNITIVE USER INTERFACES (Adam D. Gerson, Lucas C. Parra, and Paul Sajda). INDEX. ABOUT THE EDITOR.
£178.16
John Wiley & Sons Inc Biomimetic Bioresponsive and Bioactive Materials
Book SynopsisThe accessible introduction to biomaterials and their applications in tissue replacement, medical devices, and more Molecular and cell biology is being increasingly integrated into the search for high-performance biomaterials and biomedical devices, transforming a formerly engineering- and materials sciencebased field into a truly interdisciplinary area of investigation. Biomimetic, Bioresponsive, and Bioactive Materials presents a comprehensive introduction to biomaterials, discussing how they are selected, designed, and modified for integration with living tissue and how they can be utilized in the development of medical devices, orthopedics, and other related areas. Examining the physico chemical properties of widely used biomaterials and their uses in different clinical fields, the book explores applications including soft and hard tissue replacement; biointeractive metals, polymers, and ceramics; and in vitro, in vivo, and ex vivo biocompatibility tests andTable of ContentsPreface xi Contributors xiii 1 HISTORY OF BIOMIMETIC, BIOACTIVE, AND BIORESPONSIVE BIOMATERIALS 1 Matteo Santin and Gary Phillips 1.1 The First Generation of Biomaterials: The Search for “The Bioinert” 1 1.1.1 Bioinert: Myth, Reality, or Utopia? 4 1.2 The Second Generation of Biomaterials: Biomimetic, Bioresponsive, Bioactive 5 1.2.1 Hydroxyapatite (HA) and Bioglass®: Cell Adhesion and Stimulation 6 1.2.2 Collagen, Fibrin Glue, and Hyaluronic Acid Hydrogels: Presenting the ECM 6 1.2.3 Chitosan and Alginate: Replacing the ECM 9 1.2.4 Poly(Lactic/Glycolic) Acid Copolymers: Encouraging Tissue Remodeling by Safe Biodegradation 10 1.2.5 Porous Metals: Favoring Mechanical Integration 11 1.3 The Third-Generation Biomaterials: Biomimicking Natural Bioactive and Bioresponsive Processes 13 1.3.1 Principal Phases of Tissue Regeneration 14 1.3.1.1 Cell Adhesion: The Cornerstone of Tissue Regeneration 16 1.3.1.2 Mechanisms of Tissue Mineralization 19 1.4 Principles of Biomimesis and Bioactivity 21 1.4.1 Biomimicking of the ECM 22 1.4.2 Biomimicking of Cell Membrane Components 24 1.4.3 Biomimicking Cell Signaling Pathways 24 1.4.3.1 Modulation of the Growth Factor Signaling by Gene Expression: Bioactive Gene Delivery Systems 25 1.5 Bioactive Biomaterials from Different Natural Sources 26 1.5.1 Silk Fibroin 26 1.5.2 Soybean-Based Biomaterials 27 1.6 Scope of This Book 29 References 30 2 SOFT TISSUE STRUCTURE AND FUNCTIONALITY 35 Gabriela Voskerician 2.1 Overview 35 2.2 Epithelial Tissue 36 2.2.1 Background 36 2.3 The Skin 37 2.3.1 Structure and Functionality 37 2.3.2 Repair, Healing, and Renewal 42 2.4 Muscle Tissue 46 2.4.1 Background 46 2.4.2 Skeletal Muscle 48 2.4.2.1 Structure and Functionality 48 2.4.2.2 Repair, Healing, and Renewal 50 2.4.3 Smooth Muscle 51 2.4.3.1 Structure and Functionality 51 2.4.3.2 Repair, Healing, and Renewal 52 2.4.4 Cardiac Muscle 54 2.4.4.1 Structure and Functionality 54 2.4.4.2 Repair, Healing, and Renewal 55 2.5 Connective Tissue 56 2.5.1 Background 56 2.5.2 Embryonic Connective Tissue 57 2.5.3 Connective Tissue Proper 58 2.5.3.1 Cells of the Connective Tissue Proper 59 2.5.3.2 Connective Tissue Proper Fibers 60 2.5.3.3 Ground Substance 63 2.5.4 Specialized Connective Tissues 64 2.5.4.1 Structure and Function 64 2.5.4.2 Repair, Healing, and Renewal of Hyaline Cartilage 66 2.6 The Foreign Body Response 68 Exercises/Questions for Chapter 2 76 References 76 3 HARD TISSUE STRUCTURE AND FUNCTIONALITY 81 Antonio Merolli and Paolo Tranquilli Leali 3.1 Definition of Hard Tissues 81 3.2 Articular Cartilage 81 3.2.1 Structure of the Articular Cartilage 82 3.2.2 Specifi c Mechanism Repair of the Articular Cartilage 83 3.3 Bone Tissue 84 3.3.1 The Structure of the Bony Tissues 85 3.3.2 The Functions of Bone Tissue 86 3.3.3 Cell Types Involved in Bone Homeostasis: The Osteoblasts and the Osteoclasts 88 3.3.4 Ossifi cation, Turnover, and Remodeling 89 3.3.5 Bone Composite Structure and Its Effect on Mechanical Performance 91 3.4 Concluding Remarks 92 Exercises/Questions for Chapter 3 92 References 93 4 BIOMEDICAL APPLICATIONS OF BIOMIMETIC POLYMERS: THE PHOSPHORYLCHOLINE-CONTAINING POLYMERS 95 Andrew L. Lewis and Andrew W. Lloyd 4.1 Historical Perspective 95 4.2 Synthesis of PC-Containing Polymers 97 4.3 Physicochemical Properties of PC-Containing Polymers 98 4.3.1 Antifouling Mechanisms of Action 98 4.3.2 Swelling Phenomena and Structural Aspects of PC Coatings 100 4.4 Stability and Mechanical Property Considerations 102 4.4.1 PC Coatings and Surface Treatments 102 4.4.2 Bulk Hydrogels and Blends 104 4.5 Biological Compatibility 105 4.5.1 Interactions with Proteins, Eukaryotic Cells, and Bacteria 105 4.5.2 Interaction with Other Tissues 107 4.6. Applications of PC Polymers 107 4.6.1 Cardiovascular Applications 107 4.6.1.1 PC-Coated Coronary Stents 108 4.6.1.2 Vascular Grafts 108 4.6.1.3 Extracorporeal Circuits 109 4.6.2 Ophthalmic Applications 110 4.6.2.1 Intraocular Lenses 110 4.6.2.2 Contact Lenses 111 4.6.2.3 Other Ocular Devices 112 4.6.3 Anti-Infective Applications 112 4.6.3.1 Urological Devices 112 4.6.3.2 Tympanostomy Tubes 112 4.6.4 Orthopedic Applications 113 4.6.5 Biosensors and Diagnostics 113 4.6.6 Separation Systems 115 4.6.7 PC Polymers for Drug Delivery 116 4.6.7.1 Drug Delivery Coatings 116 4.6.7.2 Gel-Based Drug Delivery Systems 119 4.6.7.3 Nano/Micro Particulate Drug and Gene Delivery 119 4.6.7.4 Drug Conjugates 122 4.6.8 Emerging Applications 122 4.7 Summary 123 Exercises/Questions for Chapter 4 124 References 125 5 BIOMIMETIC, BIORESPONSIVE, AND BIOACTIVE MATERIALS: INTEGRATING MATERIALS WITH TISSUE 141 Roberto Chiesa and Alberto Cigada 5.1 Introduction 141 5.2 Mandatory Requirements for Metals as Implantable Materials 142 5.2.1 Stiffness 142 5.2.2 Strength 143 5.2.3 Corrosion Resistance 144 5.2.3.1 General Corrosion 144 5.2.3.2 Crevice Corrosion 145 5.2.3.3 Fretting Corrosion 145 5.2.3.4 Galvanic Corrosion 145 5.3 Biocompatibility of Metals 145 5.3.1 ISO Standardized Metal Family 146 5.3.1.1 Stainless Steels 146 5.3.1.2 Cobalt Alloys 148 5.3.1.3 Titanium and Titanium Alloys 149 5.4 Surface Treatments of Metals for Biomedical Applications 150 5.4.1 Cathodic Deposition Treatments 152 5.4.2 Anodic Oxidation 152 Exercises/Questions for Chapter 5 157 References 157 6 CERAMICS 161 Montserrat Espanol, Román A. Pérez, Edgar B. Montufar, and Maria-Pau Ginebra 6.1 Historical Perspective 161 6.2 Biostable Ceramics 162 6.2.1 Alumina 163 6.2.2 Zirconia 164 6.3 Bioactive and Resorbable Ceramics 165 6.3.1 Basic Concepts 165 6.3.2 Glasses and Glass–Ceramics 166 6.3.2.1 Physicochemical Properties of Bioactive Glasses 167 6.3.2.2 Silicate-Based Glasses 168 6.3.2.3 Phosphate-Based Glasses 170 6.3.2.4 Processing of Glass and Glass–Ceramics 170 6.3.3 Calcium Phosphates 172 6.3.3.1 Physicochemistry of Calcium Phosphates 172 6.3.3.2 Processing of Calcium Orthophosphates 175 6.3.4 New Trends in Bioactive and Resorbable Materials Integration 178 Exercises/Questions for Chapter 6 183 References 184 7 BIOFUNCTIONAL BIOMATERIALS OF THE FUTURE 191 Mário Barbosa, Gary Phillips, and Matteo Santin 7.1 Clinically Led Next Generation Biomaterials 191 7.1.1 Wound Dressings and Dermal Substitutes 192 7.1.2 Vascular Grafts and Cardiovascular Stents 193 7.1.3 Joint Implants and Cartilage Tissue Engineering 194 7.1.4 Bone Fillers 195 7.1.5 Nerve Guides 195 7.1.6 Ophthalmologic Devices 195 7.2 Biomacromolecule-Inspired Biomaterials 196 7.2.1 Artificial Laminin 196 7.2.2 Artificial Elastin 197 7.2.3 Artificial Collagen 197 7.2.4 GAG- and PGN-Mimicking Biomaterials 197 7.3 Nanostructured Biomimetic, Bioresponsive, and Bioactive Biomaterials 198 7.3.1 Nanofabrication of Biomaterials 198 7.3.1.1 2D Techniques 199 7.3.1.2 3D Techniques 199 7.3.1.3 Polymeric Dendrimers 200 7.3.1.4 Self-Assembling Peptides 201 7.4 Conclusions 202 Exercises/Questions for Chapter 7 203 References 203 Index 207
£83.66
John Wiley & Sons Inc Ethics in Speech and Language Therapy
Book SynopsisEthics in Speech and Language Therapy is a key text for students, practitioners and managers alike. The demands of practice, legislation, registration and the recognition of competencies all point to the need for speech and language therapists to be explicitly educated about ethics.Trade Review"This is really thought-provoking - far from a dry, dull book about ethical theories and principles . . . this book is an excellent resource for helping us think more deeply about our work-related ethical challenges." (Speech & Language Therapy in Practice, 1 July 2011)Table of ContentsList of contributors. Preface. Acknowledgements. 1. Introduction. 2. Practising Ethically. 3. Dysphagia. 4. Intellectual and Sensory Impairment. 5. Acquired Language Disorders. 6. Paediatric Speech and Language Disorders. 7. Degenerative Conditions in Ageing. 8. Service Provision and Management. 9. Common Themes and Emerging Trends.
£50.30
Wiley An Introduction to Statistics in Early Phase
Book SynopsisThis guide offers an overview of the most common types of trial undertaken in early clinical development. The coverage discusses the different methodologies and the impact of new technologies, both clinical and statistical, on clinical development.Trade Review"An Introduction to Statistics in Early Phase Trials" is an admirably concise and practical guide to the pertinent context, principles and formulae for statisticians inexpert in the application of their discipline to Phase I and II clinical research". (Journal of Clinical Research Best Practices, 1 March 2011) “An Introduction to Statistics in Early Phase Trials provides concise descriptions of many early phase trial designs, along with the statistical equations necessary to gather and analyze the data” (Annals of Pharmacotherapy, 2010) "I enjoyed reading the work of Dr. Julious, Tan, and Machin,found it quite useful, and recommend it to others teaching about, working with, or considering work in the learning phase of drug development." (Journal of Biopharmaceutical Statistics, 2011) Table of ContentsChapter 1 Early phase trials 1 Chapter 2 Introduction to pharmacokinetics 13 Chapter 3 Sample size calculations for clinical trials 37 Chapter 4 Crossover trial basics 55 Chapter 5 Multi-period crossover trials 71 Chapter 6 First time into man 87 Chapter 7 Bayesian and frequentist methods 113 Chapter 8 First-time-into-new-population studies 125 Chapter 9 Bioequivalence studies 139 Chapter 10 Other Phase I trials 169 Chapter 11 Phase II trials: general issues 187 Chapter 12 Dose–response studies 197 Chapter 13 Phase II trials with toxic therapies 211 Chapter 14 Interpreting and applying early phase trial results 223 Chapter 15 Go/No-Go criteria 231 Appendix 245 References 251 Index 257
£80.96
John Wiley & Sons Inc The Old Age Psychiatry Handbook A Practical Guide
Book SynopsisThe Old Age Psychiatry Handbook provides a comprehensive but concise overview of psychiatric, medical and practical issues that may arise within the speciality. The book is written in an easy assimilated format, ideal for use in the clinic and on the ward.Trade Review"A practical guide to “coal-face” old age psychiatry. The book is packed with the kind of information it takes many years of practice to accumulate, and presents the information in a very easily digestible form. If the giants of old age psychiatry had told stories to trainees, this is what they would have told. It is clearly and concisely written." (International Journal of Geriatric Psychiatry, February 2009) "The book is written in an easy assimilated format, ideal for use in the clinic and on the ward." (Doody's, June 2008)Table of ContentsPreface. Acknowledgements. 1 The Assessment of Patients in Old Age Psychiatry. Introduction. Setting. The psychiatric history in older patients. The Mental State Examination (MSE). Assessing cognition with limited time. Assessment of everyday functioning. Physical examination. Investigations. Neuropsychiatric testing and the memory clinic. Assessment of carers. Summary. Further reading. 2 Dementia. Definition and diagnosis of dementia. Assessment of a patient with dementia. General management of dementia. Behavioural and psychological symptoms of dementia. Why differentiate between the dementias? Alzheimer’s disease. Vascular dementia. Dementia with Lewy bodies. Frontotemporal dementia. Less common causes of dementia. Mild cognitive impairment. Functional and molecular neuroimaging in dementia. Further reading. 3 Depression. Epidemiology. Clinical features and diagnosis. Risk factors for depression in old age. Treatment. Outcome. Prevention of depression in the elderly. Depression and dementia. Bereavement. Suicide. Further reading. 4 Bipolar Affective Disorder. Epidemiology. Aetiology. Clinical features and diagnosis. Management. 5 Anxiety Disorders and Obsessive Compulsive Disorder. Anxiety in the elderly. Generalised anxiety disorder. Panic disorder. Phobic disorders. Post-traumatic stress disorder. Other reactions to stress. Obsessive compulsive disorder. Further reading. 6 Psychotic Illness. Schizophrenia. Schizoaffective disorder. Delusional disorder. Further reading. 7 Personality Disorders. Personality. Personality and age. Definition and classification of personality disorders. Personality disorders in old age. Management of personality disorder in old age. Further reading. 8 Alcohol. Current guidelines for alcohol consumption. Definitions. Epidemiology. Detection and screening. Consequences. Management. Further reading. 9 Insomnia. Sleep architecture. Circadian rhythm. Insomnia and consequences in the elderly. Causes of insomnia. Assessment of a patient with insomnia. Non-pharmacological management. Pharmacological management. Further reading. 10 Psychopharmacology. Principles of drug treatment in old age psychiatry. Adherence. Pharmacokinetics and pharmacodynamics. Adverse drug reactions and interactions. Antidepressant drugs. Lithium. Anticonvulsant mood stabilisers. Antipsychotic drugs. Anxiolytics and hypnotics. Drugs used in dementia. Further reading. 11 Electroconvulsive Therapy. Indications. Mechanism of action. Efficacy. Adverse effects. Cautions. Consent. ECT and the Mental Health Act. Pre-ECT physical work-up. Medication and ECT. ECT procedure. Prevention of relapse. Further reading. 12 Psychological Therapies. Cognitive behavioural therapy. Behavioural therapy. Psychoanalytic psychotherapy. Further reading. 13 Practical, Legal and Social Issues. Provision of services. Legal issues in old age psychiatry. Social and financial issues in old age. Further reading. 14 Physical Illness and Old Age Psychiatry. Delirium. Vascular disease. Neurological disease. Rheumatological disease. Endocrinological disease. Nutritional deficit. Neoplastic disease. Palliative care. Further reading. Appendices. Index.
£52.20
John Wiley & Sons Inc Computer Modeling in Bioengineering
Book SynopsisBioengineering is a broad-based engineering discipline that applies engineering principles and design to challenges in human health and medicine, dealing with bio-molecular and molecular processes, product design, sustainability and analysis of biological systems. Applications that benefit from bioengineering include medical devices, diagnostic equipment and biocompatible materials, amongst others. Computer Modeling in Bioengineering offers a comprehensive reference for a large number of bioengineering topics, presenting important computer modeling problems and solutions for research and medical practice. Starting with basic theory and fundamentals, the book progresses to more advanced methods and applications, allowing the reader to become familiar with different topics to the desired extent. It includes unique and original topics alongside classical computational modeling methods, and each application is structured to explain the physiological background, phenomena that arTable of ContentsContributors. Preface. Part I: Theoretical Background of Computational Methods. 1. Notation - Matrices and Tensors. 2. Fundamentals of Continuum Mechanics. 3. Heat Transfer, Diffusion, Fluid Mechanics, and Fluid Flow through Porous Deformable Media. Part II: Fundamentals of Computational Methods. 4. Isoparametric Formulation of Finite Elements. 5. Dynamic Finite Element Analysis. 6. Introduction to Nonlinear Finite Element Analysis. 7. Finite Element Modeling of Field Problems. 8. Discrete Particle Methods for Modeling of Solids and Fluids. Part III: Computational Methods in Bioengineering. 9. Introduction to Bioengineering. 10. Bone Modeling. 11. Biological Soft Tissue. 12. Skeletal Muscles. 13. Blood Flow and Blood Vessels. 14. Modeling Mass Transport and Thrombosis in Arteries. 15. Cartilage Mechanics. 16. Cell Mechanics. 17. Extracellular Mechanotransduction: Modeling Ligand Concentration Dynamics in the Lateral Intercellular Space of Compressed Airway Epithelial Cells. 18. Spider Silk: Modeling Solvent Removal during Synthetic and Nephila clavipes Fiber Spinning. 19. Modeling in Cancer Nanotechnology. Index.
£117.85
John Wiley & Sons Inc Understanding and Treating Psychogenic Voice
Book SynopsisThis book offers the speech and language therapist studying or working in the field of psychogenic voice disorders a comprehensive understanding of how they present, a classification system and guidance on assessment and treatment.Trade Review"This text is value for money, easy to dip into and a comprehensive resource for any level of experience.... Its style is accessible and it is widely referenced with an invaluable summary at the end of each chapter." (Speech & Language Therapy in Practice, Summer 2009) "This book fleshes out areas which have been ignored and malnourished in the understanding and treatment of voice." (Doody's Health Services)Table of ContentsAbout the Authors ix Foreword xi Foreword xiii Preface xv Acknowledgements xvii 1 Psychogenic Voice Disorders – A New Model 1 2 Introducing the Cognitive Behaviour Therapy Model 31 3 Cognitive Behaviour Therapy: Essential Assessment Principles and Therapist Skills 39 4 Assessment of Voice and Personal History 57 5 Symptomatic Voice Therapy Approaches 89 6 Assessing Anxiety in Voice Patients 105 7 Treating Anxiety in Voice Patients 119 8 Treating Lowered Mood in Voice Patients 139 9 Psychological Disorders: Deciding When Not to Treat 157 10 Case Studies 175 References 207 Index 213
£64.76
John Wiley & Sons Inc Injury Biomechanics and Control
Book SynopsisWith this book as their guide, readers will discover how to design better protective equipment and devices such as helmets, seat belts, and wheelchairs in order to minimize the risk or the extent of injury to people subjected to impact loads. It is based on the theory of optimal shock isolation, first developed in the 1950s to protect missile systems from intensive shock loads. Using examples from automotive, aviation, and military areas, the authors demonstrate how optimal shock isolation theory enables designers to improve the performance of protective equipment by incorporating control and optimization methods developed for shock isolation systems. The first part of Injury Biomechanics and Control lays down the engineering foundation, setting forth core principles and techniques, including: Fundamentals of impact and shock isolation systems Basic optimal shock isolation for single-degree-of-freedom systems OptimaTable of ContentsPREFACE. BASIC TERMINOLOGY. CHAPTER 1 INTRODUCTION. 1.1 The Structure of the Book. 1.2 Related Studies. References. CHAPTER 2 FUNDAMENTALS OF IMPACT AND SHOCK ISOLATION. 2.1 Shock Loading: Basic Models and Characteristics. 2.2 Shock Isolation. 2.3 The Isolator as a Control Medium: Active and Passive Isolators. 2.4 Does Isolation of an Object from the Base Always Lead to a Reduction in the Shock Load Transmitted to the Object?. References. CHAPTER 3 BASIC OPTIMAL SHOCK ISOLATION: SINGLE DEGREE OF FREEDOM SYSTEMS. 3.1 Basic Problems. 3.2 Limiting Performance Analysis: Basic Concept and Analytical Results. 3.3 Limiting Performance Analysis: Computational Approach. 3.4 Parametric Optimization. 3.5 Pre-Acting Control for Shock Isolators. 3.6 Best and Worst Disturbance Analyses. References. CHAPTER 4 OPTIMAL SHOCK ISOLATION FOR MULTI-DEGREE-OF-FREEDOM SYSTEMS. 4.1 Optimal Shock Isolation for a Two-Component Viscoelastic Object. 4.2 Optimal Shock Isolation for Three-Component Structures. References. CHAPTER 5 SPINAL INJURY CONTROL. 5.1 Description of the Model. 5.2 Minimization of the Occupant’s Displacement subject to a Constraint Imposed on the Spinal Compressive Force. 5.3 Spinal Injury Control System with two Shock Isolators. 5.4 MADYMO Simulation for the Limiting Performance Analysis. References. CHAPTER 6 THORACIC INJURY CONTROL. 6.1 Smart Restraint Systems. 6.2 Basic Concept of Restraint Force Control. 6.3 Limiting Performance Analysis for the Prevention of Thoracic Injuries in a Frontal Car Crash. 6.4 Feedback Control of the Elastic Restraint Force on the Basis of the Two-Mass Thorax Injury Model. 6.5 Conclusions. References. CHAPTER 7 HEAD INJURY CONTROL. 7.1 Head Injury Criterion: Historical Perspectives. 7.2 Minimization of the Deceleration Distance for Constrained HIC. 7.3 Minimization of the HIC for Constrained Deceleration Distance. 7.4 Alternative Control Laws. References. CHAPTER 8 INJURY CONTROL FOR WHEELCHAIR OCCUPANTS. 8.1 Introduction. 8.2 Optimal Shock Isolation of Single-Degree-of-Freedom System. 8.3 Simulation Using MADYMO. 8.4 Discussion. References. Index.
£104.36
John Wiley & Sons Inc Quantitative Imaging Tools for Lung Cancer Drug
Book SynopsisThis book presents chapters written by leading clinical researchers in the field of lung cancer, where high resolution 3-D imaging technology appears to hold the greatest near-term promise.Table of ContentsPreface (Thomas M. Baer and James L. Mulshine). Chapter 1: Incorporating Imaging into Drug Development: An Industry Perspective (Philip S. Murphy and Debasish Roychowdhury). Chapter 2: Developing Imaging Tools for Drug Development: Critical Technology, Clinical Data and Regulatory (Rafal Dziadziuszko, Fred R. Hirsch and Paul A. Bunn, Jr). Chapter 3: Quantitative Imaging in CT Lung Cancer Drug Development and Evaluation (Ricardo S. Avila). Chapter 4: Volumetric CT Imaging for Response Assessment in Lung Cancer: A Platform for Translational Research (Binsheng Zhao and Lawrence H. Scwhartz). Chapter 5: Emerging Radiological Software Standards and Development Technologies: Impact on Clinical Translation and Trials (John Pearson, Lawrence Tarbox, Gianluca Paladini, John G. Wolodzko, Paula M. Jacobs, and Zhenghong Lee). Chapter 6: Statistical Considerations Underlying Therapeutic Response Criteria for Lung Cancer: A Review in the Context of Emergence of Multi-Slice CT Scanner and Computer Assisted Diagnostic Algorithm for Volumetric Assessment (Madhu Mazumdar and Xi Kathy Zhou). Chapter 7: Programs Supporting Quantitative Imaging in Biomedicine at the National Institute for Standards and Technology (Thomas M. Baer and Charles W. Clark). Appendix A: Evolving Imaging Resources: Public Access Databases (Laurence Clarke). Appendix B: Biomedical Imaging Archive Network (Thomas M. Baer and James L. Mulshine). Appendix C: Developing CT Image-Processing Tools to Accelerate Progress in Lung Cancer Drug Development (James L. Mulshine, Ricardo S. Avila, Fred R. Hirsch, and David Yankelevitz).
£125.96
John Wiley & Sons Inc Biosensing Using Nanomaterials Wiley Nanoscience
Book SynopsisThis book introduces novel concepts in the area of bioanalysis based on nanomaterials, opening new opportunities for basic research and new tools for real bioanalytical applications. Each chapter provides a theoretical overview of a different topic and includes an annex that describes the most interesting aspect related to the bioanalytical system.Table of ContentsCONTRIBUTORS. SERIES PREFACE. PREFACE. PART I CARBON NANOTUBES. 1. Carbon Nanotube–Based Sensors and Biosensors (Richard G. Compton, Gregory G. Wildgoose, and Elicia L. S. Wong). 1.1. Introduction to the Structure of Carbon Nanotubes. 1.2. Electroanalysis Using CNT-Modified Electrodes. 1.3. Advantageous Application of CNTs in Sensors: pH Sensing. 1.4. Carbon Nanotube–Based Biosensors. 1.5. Using CNTs in Biosensor Production for Medical Diagnostics and Environmental Applications. References. 2. Isotropic Display of Biomolecules on CNT-Arrayed Nanostructures (Mark R. Contarino, Gary Withey, and Irwin Chaiken). 2.1. Introduction: CNT Arrays for Biosensing. 2.2. Functionalization of CNTs: Controlling Display Through Covalent Attachment. 2.3. Self-Assembling Interfaces: Anchor-Probe Approach. 2.4. Molecular Wiring of Redox Enzymes. 2.5. Multiplexing Biomolecules on Nanoscale CNT Arrays. 2.6. Conclusions. References. 3. Interaction of DNA with CNTs: Properties and Prospects for Electronic Sequencing (Sheng Meng and Efthimios Kaxiras). 3.1. Introduction. 3.2. Structural Properties of Combined DNA–CNT Systems. 3.3. Electronic Structure. 3.4. Optical Properties. 3.5. Biosensing and Sequencing of DNA Using CNTs. 3.6. Summary. References. PART II NANOPARTICLES. 4. Improved Electrochemistry of Biomolecules Using Nanomaterials (Jianxiu Wang, Andrew J. Wain, Xu Zhu, and Feimeng Zhou). 4.1. Introduction. 4.2. CNT-Based Electrochemical Biosensors. 4.3. Nanoparticle-Based Electrochemical Biosensors. 4.4. Quantum Dot–Based Electrochemical Biosensors. 4.5. Conclusions and Outlook. References. 5. The Metal Nanoparticle Plasmon Band as a Powerful Tool for Chemo- and Biosensing (Audrey Moores and Pascal Le Floch). 5.1. Introduction. 5.2. The SPB: An Optical Property of Metal NPs. 5.3. Plasmon Band Variation Upon Aggregation of Nanoparticles. 5.4. Plasmon Band Variation on the Environment or Ligand Alteration. 5.5. Metal Nanoparticles as Labels. 5.6. Conclusions. References. 6. Gold Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors (Adriano Ambrosi, Alfredo de la Escosura-Mun˜ iz, Maria Teresa Castaneda, and Arben Merkoci). 6.1. Introduction. 6.2. Synthesis of AuNPs. 6.3. Characterization of AuNPs. 6.4. AuNPs as Detecting Labels for Affinity Biosensors. 6.5. Conclusions. References. 7. Quantum Dots for the Development of Optical Biosensors Based on Fluorescence (W. Russ Algar and Ulrich J. Krull). 7.1. Introduction. 7.2. Quantum Dots. 7.3. Basic Photophysics and Quantum Confinement. 7.4. Quantum Dot Surface Chemistry and Bioconjugation. 7.5. Bioanalytical Applications of Quantum Dots as Fluorescent Labels. 7.6. Fluorescence Resonance Energy Transfer and Quantum Dot Biosensing. 7.7. Summary. References. 8. Nanoparticle-Based Delivery and Biosensing Systems: An Example (Almudena Mun˜oz Javier, Pablo del Pino, Stefan Kudera, and Wolfgang J. Parak). 8.1. Introduction. 8.2. Functional Colloidal Nanoparticles. 8.3. Polyelectrolyte Capsules as a Functional Carrier System. 8.4. Uptake of Capsules by Cells. 8.5. Delivery and Sensing with Polyelectrolyte Capsules. 8.6. Conclusions. References. 9. Luminescent Quantum Dot FRET-Based Probes in Cellular and Biological Assays (Lifang Shi, Nitsa Rosenzweig, and Zeev Rosenzweig). 9.1. Introduction. 9.2. Luminescent Quantum Dots. 9.3. Fluorescence Resonance Energy Transfer. 9.4. Quantum Dot FRET-Based Protease Probes. 9.5. Summary and Conclusions. References. 10. Quantum Dot–Polymer Bead Composites for Biological Sensing Applications (Jonathan M. Behrendt and Andrew J. Sutherland). 10.1. Introduction. 10.2. Quantum Dot–Composite Construction. 10.3. Applications of QD Composites. 10.4. Future Directions. References. 11. Quantum Dot Applications in Biomolecule Assays (Ying Xu, Pingang He, and Yuzhi Fang). 11.1. Introduction to QDs and Their Applications. 11.2. Preparation of QDs for Conjugation with Biomolecules and Cells. 11.3. Special Optoelectronic Properties in the Bioemployment of QDs. 11.4. Employment of QDs as Biosensing Indicators. References. 12. Nanoparticles and Inductively Coupled Plasma Mass Spectroscopy–Based Biosensing (Arben Merkoc¸i, Roza Allabashi, and Alfredo de la Escosura-Muniz). 12.1. ICP-MS and Application Possibilities. 12.2. Detection of Metal Ions. 12.3. Detection of Nanoparticles. 12.4. Analysis of Metal-Containing Biomolecules. 12.5. Bioanalysis Based on Labeling with Metal Nanoparticles. 12.6. Conclusions. References. PART III NANOSTRUCTURED SURFACES. 13. Integration Between Template-Based Nanostructured Surfaces and Biosensors (Walter Vastarella, Jan Maly, Mihaela Ilie, and Roberto Pilloton). 13.1. Introduction. 13.2. Nanosphere Lithography. 13.3. Nanoelectrodes Ensemble for Biosensing Devices. 13.4. Concluding Remarks. References. 14. Nanostructured Affinity Surfaces for MALDI-TOF-MS–Based Protein Profiling and Biomarker Discovery (R. M. Vallant, M. Rainer, M. Najam-Ul-Haq, R. Bakry, C. Petter, N. Heigl, G. K. Bonn, and C. W. Huck). 14.1. Proteomics and Biomarkers. 14.2. MALDI in Theory and Practice. 14.3. Carbon Nanomaterials. 14.4. Near-Infrared Diffuse Reflection Spectroscopy of Carbon Nanomaterials. References. PART IV NANOPORES. 15. Biosensing with Nanopores (Ivan Vlassiouk and Sergei Smirnov). 15.1. Nanoporous Materials in Sensing. 15.2. Nanochannel and Nanopore Fabrication. 15.3. Surface Modification Chemistry 15.4. Nonelectrical Nanoporous Biosensors. 15.5. Electrical Nanoporous Biosensors. 15.6. Summary. References. INDEX.
£152.06
John Wiley & Sons Inc Mass Spectrometry in Sports Drug Testing
Book Synopsis* Mass Spectrometry is a major tool to characterize, identify and detect hundreds of known and unknown drugs.Trade Review“Mass Spectrometry in Sports Drug Testing is an excellent textbook for anyone involved in the analytical characterization of illicit substances and abused drugs.” (Anal Bioanal Chem, 2011) Table of ContentsPreface. Acknowledgments. 1 History of Sports Drug Testing. 1.1 Historical Attempts of Artificial Performance Enhancement. 1.2 Background and Rationale of Doping Controls. 1.3 Early Detection Methods: Possibilities and Limitations of Assays Without Mass Spectrometry. 1.4 Introduction of Mass Spectrometry to Doping Control Analysis. References. 2. Mass Spectrometry and the List of Prohibited Substances and Methods of Doping. 2.1 Criteria for the Mass Spectrometric Identification of Prohibited Compounds. 2.2 Modern Mass Spectrometers in Doping Controls: Advantages and Disadvantages of Available Techniques. References. 3. Structure Characterization of Low Molecular Weight Target Analytes —Electron Ionization. 3.1 Stimulants. 3.2 Narcotics. 3.3 Anabolic Androgenic Steroids. 3.4 Selective Androgen Receptor Modulators (SARMs). 3.5 Diuretics. 3.6 β2-Agonists. 3.7 β-Receptor Blocking Agents. 3.8 Calcium-Channel Modulators (RYCALS). 3.9 Carbohydrate-Based Agents. References. 4. Structure Characterization of Low Molecular Weight Target Analytes: Electrospray Ionization. 4.1 Stimulants. 4.2 Narcotics. 4.3 Anabolic Androgenic Steroids. 4.4 Selective Androgen Receptor Modulators (SARMs). 4.5 Diuretics. 4.6 β2-Agonists. 4.7 Calcium-Channel Modulators (RYCALS). 4.8 Peroxisome-Proliferator Activated Receptor-δ (PPARδ) And Adenosine Monophosphate Activated Protein Kinase (AMPK) Agonists. 4.9 Hypoxia-Inducible Factor (HIF)-Stabilizers And Sirtuin Activators. 4.10 β-Receptor Blocking Agents. 4.11 Glucuronic Acid and Sulfate Conjugates of Target Analytes. References. 5. Structure Characterization of High Molecular Weight Target Analytes: Electrospray Ionization. 5.1 Human Chorionic Gonadotrophin (hCG). 5.2 Erythropoietins (EPO). 5.3 Synacthen. 5.4 Insulins. 5.5 Hemoglobin-Based Oxygen Carriers (HBOCs). 5.6 Human Growth Hormone (hGH). 5.7 Sermorelin (Geref). 5.8 Insulin-Like Growth Factor-1 (IGF-1). 5.9 Gonadorelin (LHRH). References. 6. Modern Mass Spectrometry-Based Analytical Assays. 6.1 GC-MS and Isotope Ratio Mass Spectrometry. 6.2 LC-MS/MS. References. 7. Limitations and Perspectives of Mass Spectrometry-Based Procedures in Doping Control Analysis. 7.1 Recombinant Biomolecules. 7.2 Unknown Compounds. 7.3 Profiling of Urine and/or Blood. 7.4 Alternative Specimens. References. Index.
£95.36
John Wiley & Sons Inc Formulating Packaging and Marketing of Natural
Book SynopsisBalanced coverage of natural cosmetics, and what it really means to be green The use of natural ingredients and functional botanical compounds in cosmetic products is on the rise. According to industry estimates, sales of natural personal care products have exceeded $7 billion in recent years. Nonetheless, many misconceptions about natural products?for instance, what green and organic really mean?continue to exist within the industry. Formulating, Packaging, and Marketing of Natural Cosmetic Products addresses this confusion head-on, exploring and detailing the sources, processing, safety, efficacy, stability, and formulation aspects of natural compounds in cosmetic and personal care products. Designed to provide industry professionals and natural product development experts with the essential perspective and market information needed to develop truly green cosmetics, the book covers timely issues like biodegradable packaging and the potential microbial risks they presTrade Review"I highly recommend this book for professionals interested in cosmetics as well as physicians, pharmacists, and naturopathic doctors, and those interested in knowing the intricate world regarding the production, regulation, packaging, benefits, and risks inherent to various natural products used as cosmetics." (Herbalgram, 1 November 2013) "Chapters are strengthened by comprehensive referencing. From pharmacology to packaging, from Ayurvedic medicine to composting of containers, it is all here. This comprehensive text may well become the definitive work on this subject." (Journal of Cosmetic Dermatology, 8 November 2011)Table of ContentsPreface Contributors Part I Market and Trends. Chapter 1. The natural personal care market (Darrin C. Duber Smith). Chapter 2. Consumer and formulator of natural cosmetic products: understanding and integrating each other needs (Yi Hsin Chang). Chapter 3. The Mechanics of Developing a Natural/Organic Non-governmental Cosmetic Standard (Amy B. Olson). Part II Regulatory Aspects. Chapter 4. Regulatory perspective of natural and organic claims for cosmetic products (Azalea Rosholt). Chapter 5. The US legal perspective on making natural and organic claims for cosmetic products (Miriam Guggenheim and Mary Joy Ballantyne). Chapter 6. Regulatory and safety aspects of natural fragrance ingredients (Anne Marrie Api and Matthias Vey). Chapter 7. Advertising self regulation- a review of cosmetic claims and natural/organic claims (Annie Ugurlayan). Part III Safety Aspects. Chapter 8. The safety assessment of plant derived ingredients in cosmetics (Viny Srinivasam and Eric Antignac). Chapter 9. Approaches to assessing consumer safety of botanical ingredients with emphasis to type I allergy (Esperanza Troyano, Donna Mc Millan, Katherine Sarlo, Lijuan Li. Rohan Wimalasena). Chapter 10. Preserving cosmetics with natural preservatives and preserving natural cometics (James Flanagan). Chapter 11. Microbial risks for Eco-friendly packaging (John Yablonki, Sharon Mancuso). Part IV Use of Natural Ingredients. Chapter 12. Formulating Natural Cosmetics with Oils, Fats, Butters, and Waxes (Mark Garrison and Nava Dayan). Chapter 13. Natural Antioxidants and their Effects on the Skin (Anne Pouillot, Luigi L. Polla, Philippe Tacchini, Alice Neequaye, Ada Polla, Barbara Polla). Chapter 14. The use of quercetin and curcumin in skin care and consumer products (Brian Kilfoyle, Dishka Kausjik, Jenna Terebeski, Sonali Bose, Bo Michniak Kohn). Chapter 15. Ayruvedic Ingredients in cosmetics (Raja Sivalenka and Mangathayaru Putrevu). Chapter 16. Formulating with traditional Chinese medicine herbs (Ina Scienoff and Robin Choi). Chapter 17. The inside-out concept as complement to the use of topical sunscreen: The case for endogenous skin photoprotection form sunlight by natural dietary actives such as tomato carotenoids (Joseph Levi and Yoav Sharoni). Part V Analysis of Naturals. Chapter 18. Chromatographic Techniques for the Analysis of Natural Products in Cosmetics (Stefan Gafner Jacquelyn R. Villinski). Chapter 19. The use of nuclear magnetic resonance spectroscopy for the identification of biomarkers for quality control of plant extracts (Kan He and Marc Roller). Part IV Biodegradation. Chapter 20. Biodegredability evaluation for cosmetic ingredients and finished products (Jennifer K. Saxe). Cahpter 21. Overview of Biodegradable Packaging, Methods and Current Trends (Gaurav Kale). Index
£114.26
John Wiley & Sons Inc Clinical Trials in Psychiatry
Book SynopsisAt last a new edition of the highly acclaimed book Clinical Trials in Psychiatry This book provides a concise but thorough overview of clinical trials in psychiatry, invaluable to those seeking solutions to numerous problems relating to design, methodology and analysis of such trials.Practical examples and applications are used to ground theory whenever possible. The Second Edition includes new information regarding: Recent important psychiatric trials More specific discussion of psychiatry in the USA and the particular problems of trials in the USA, including comments about the FDA (U.S. Food and Drug Administration) An extended chapter on meta-analysis Further discussion of sub-group analysis Special features include appendices outlining how to design and report clinical trials, what websites and software programs are appropriate and an extensive reference section. From the reviews of the First EdiTrade Review"A book to read from beginning to end.... Clinical Trials in Psychiatry covers all the most important issues and will be useful to all clinicians who are involved in conducting, or using the results of, clinical trials. It provides a highly persuasive account of the unique scientific advantages of randomised trials for those who remain unconvinced. It is very readable." (British Journal of Psychiatry, February 2009) "On balance, readers looking for a practical text to introduce them to the key issues will be well-satisfied with Clinical Trials in Psychiatry." (Journal of Biopharmaceutical Statistics, Volume 19, Issue 1, 2009) "On balance, readers looking for a practical text to introduce them to the key issues will be well-satisfied with Clinical Trials in Psychiatry." (Journal of Biopharmaceutical Statistics, Volume 19, Issue 1, 2009)Table of ContentsPreface to the first edition. Preface to the second edition. 1. Treatments, good, bad or worthless – and how do we tell? 1.1 Treatments worthless – and worse. 1.2 A brief history of treating the mentally ill. 1.3 Summary. 2. The randomized clinical trial. 2.1 Introduction. 2.2 The clinical trial. 2.3 Ethical issues in clinical trials. 2.4 Informed consent. 2.5 Compliance. 2.6 Summary. 3. Design issues in clinical trials. 3.1 Introduction. 3.2 Clinical trial designs. 3.3 Methods of randomization. 3.4 Methods of masking treatments. 3.5 The size of a clinical trial. 3.6 Interim analysis. 3.7 Summary. 4. Special problems of trials in psychiatry. 4.1 Introduction. 4.2 Explanatory versus pragmatic trials. 4.3 Complex interventions. 4.4 Outcome measures in psychiatry. 4.5 Summary. 5. Some statistical issues in the analysis of psychiatric trials. 5.1 Introduction. 5.2 P-values and confidence intervals. 5.3 Using baseline data. 5.4 Longitudinal data. 5.5 Missing values and dropouts in longitudinal data. 5.6 Multiple outcome measures. 5.7 Intention-to-treat. 5.8 Economic evaluation of trials. 5.9 Number needed to treat. 6. Analysing data from a psychiatric trial: an example. 6.1 Introduction. 6.2 Beating the Blues. 6.3 Analysis of the post-treatment BDI scores. 6.4 Graphical displays and summary measure analysis of longitudinal data. 6.5 Random effects models for the BtB data. 6.6 The dropout problem in the BtB data. 6.7 Summary. 7. Systematic reviews and meta-analysis. 7.1 Introduction. 7.2 Study selection. 7.3 Publication bias. 7.4 The statistics of meta-analysis. 7.5 Some examples of meta-analysis of psychiatric trials. 7.6 Summary. 8. RCTs in psychiatry: threats, challenges and the future. 8.1 Introduction. 8.2 Can randomized clinical trials in psychiatry be justified? 8.3 Are randomized clinical trials really necessary? 8.4 Conflicts of interest. 8.5 Scandals, trials and tribulations. 8.6 The future of psychiatric trials. 8.7 Defending the clinical trial. 8.8 Summary. Appendix A. Issues in the management of clinical trials- 'how to do it'. A.1 Introduction. A.2 Clinical trial protocols. A.3 Getting the costs right. A.4 Collecting and managing the data. A.5 Writing the patient information sheet. A.6 Getting informed consent. A.7 Maintaining recruitment. A.8 Useful web sites. Appendix B. Writing a trial report. B.1 Introduction. Appendix C. Useful software for clinical trials. C.1 Introduction. C.2 Data management. C.3Design. C.4 Analysis. Bibliography. Index.
£85.45
John Wiley & Sons Inc Cochlear Hearing Loss
Book SynopsisSince the first edition was published in 1998, considerable advances have been made in the fields of pitch perception and speech perception. In addition, there have been major changes in the way that hearing aids work, and the features they offer. This book will provide an understanding of the changes in perception that take place when a person has cochlear hearing loss so the reader understands not only what does happen, but why it happens. It interrelates physiological and perceptual data and presents both this and basic concepts in an integrated manner. The goal is to convey an understanding of the perceptual changes associated with cochlear hearing loss, of the difficulties faced by the hearing-impaired person, and the limitations of current hearing aids.Table of ContentsPreface. Chapter 1. Physiological Aspects of Cochlear Hearing Loss. I. INTRODUCTION. II.LINEAR AND NONLINEAR SYSTEMS. III. STRUCTURE AND FUNCTION OF THE OUTER AND MIDDLE EAR. IV. STRUCTURE AND FUNCTION OF THE NORMAL COCHLEA. 1. The cochlea, the basilar membrane and the organ of Corti. 2. Tuning on the basilar membrane. 3. The nonlinearity of input-output functions on the BM. 4. Two-tone suppression. 5. Combination tone generation. 6. Responses of the BM to complex sounds. 7. Otoacoustic emissions. V. NEURAL RESPONSES IN THE NORMAL AUDITORY NERVE. 1. Spontaneous firing rates and thresholds. 2. Tuning curves and iso-rate contours. 3. Rate-versus-level functions. 4. Two-tone suppression. 5. Phase locking. VI. TYPES OF HEARING LOSS. VII. PHYSIOLOGY OF THE DAMAGED COCHLEA. 1. BM responses. 2. Neural responses. 3. Structure-function correlation. 4. Otoacoustic emissions. 5. Phase locking. VIII. CONCLUSIONS. Chapter 2. Absolute Thresholds. I. INTRODUCTION. II. MEASURES OF ABSOLUTE THRESHOLD. 1. Minimum audible pressure (MAP). 2. Minimum audible field (MAF). 3. Comparison of MAP and MAF. 4. The audiogram. III. DESCRIPTIONS OF THE SEVERITY OF HEARING LOSS. IV. CAUSES OF HEARING LOSS DUE TO COCHLEAR DAMAGE. V. PERCEPTUAL CONSEQUENCES OF ELEVATED ABSOLUTE THRESHOLDS. Chapter 3. Masking, Frequency Selectivity and BM Nonlinearity. I. INTRODUCTION. II. THE MEASUREMENT OF FREQUENCY SELECTIVITY USING MASKING. 1. Introduction. 2. The power spectrum model. 3. Estimating the shape of a filter. III. ESTIMATING FREQUENCY SELECTIVITY FROM MASKING EXPERIMENTS. 1. Psychophysical tuning curves. 2. The notched-noise method. IV. CHARACTERISTICS OF THE AUDITORY FILTER IN NORMAL HEARING. 1. Variation with centre frequency. 2. Variation with level. 3. Summary. V. MASKING PATTERNS AND EXCITATION PATTERNS. 1. Masking patterns. 2. Relationship of the auditory filter to the excitation pattern. 3. Changes in excitation patterns with level. 4. Possible effects of suppression. VI. NON-SIMULTANEOUS MASKING. 1. Basic properties of non-simultaneous masking. 2. Evidence for suppression from non-simultaneous masking. 3. The enhancement of frequency selectivity revealed in non-simultaneous masking. 4. Relation between the growth of forward masking and the BM input-output function. VII. THE AUDIBILITY OF PARTIALS IN COMPLEX TONES. VIII. EFFECTS OF COCHLEAR DAMAGE ON FREQUENCY SELECTIVITY IN SIMULTANEOUS MASKING. 1. Complicating factors. 2. Psychophysical tuning curves. 3. Auditory filter shapes measured with notched noise. IX. THE USE OF MASKING TO DIAGNOSE DEAD REGIONS. 1. The TEN test. 2. The TEN(HL) test. 3. Prevalence of dead regions assessed using the TEN(HL) test. X. EFFECTS OF COCHLEAR DAMAGE ON FORWARD MASKING AND SUPPRESSION . XI. EFFECTS OF COCHLEAR HEARING LOSS ON BM INPUT-OUTPUT FUNCTIONS. XII. PERCEPTUAL CONSEQUENCES OF REDUCED FREQUENCY SELECTIVITY, LOSS OF SUPPRESSION AND STEEPER BM INPUT-OUTPUT FUNCTIONS. 1. Susceptibility to masking. 2. Timbre perception. 3. Perceptual consequences of dead regions. Chapter 4. Loudness Perception and Intensity Resolution. I. INTRODUCTION. II. LOUDNESS PERCEPTION FOR NORMALLY HEARING PEOPLE. 1. Equal-loudness contours and loudness level. 2. The scaling of loudness. 3. The detection of intensity changes. III. EFFECTS OF COCHLEAR HEARING LOSS ON LOUDNESS PERCEPTION. IV. A MODEL OF NORMAL LOUDNESS PERCEPTION. V. A MODEL OF LOUDNESS PERCEPTION APPLIED TO COCHLEAR HEARING LOSS. 1. Introduction. 2. Elevation of absolute threshold. 3. Reduced compressive nonlinearity. 4. Reduced IHC/neural function. 5. Reduced frequency selectivity. 6. Complete loss of functioning IHCs or neurones (dead regions). 7. Using the model to account for loudness recruitment. VI. EFFECTS OF BANDWIDTH ON LOUDNESS . 1. Normal hearing. 2. Impaired hearing. VII. EFFECTS OF COCHLEAR HEARING LOSS ON INTENSITY RESOLUTION. VIII. PERCEPTUAL CONSEQUENCES OF ALTERED LOUDNESS PERCEPTION. 1. Consequences of loudness recruitment and reduced dynamic range. 2. Perceptual consequences of reduced loudness summation. 3. Perceptual consequences of altered intensity discrimination. Chapter 5. Temporal Resolution and Temporal Integration. I. INTRODUCTION. II. MODELLING WITHIN-CHANNEL TEMPORAL RESOLUTION IN NORMAL HEARING. 1. Bandpass filtering. 2. The nonlinearity. 3. The sliding temporal integrator. 4. The decision device. 5. Characterising the nonlinear device and the sliding temporal integrator. III. TEMPORAL RESOLUTION IN NORMAL HEARING. 1. The effect of centre frequency on gap detection. 2. Temporal modulation transfer functions. 3. The rate of recovery from forward masking. IV. TEMPORAL RESOLUTION IN PEOPLE WITH COCHLEAR DAMAGE. 1. The influence of sound level on gap detection and the rate of decay of forward masking. 2. The influence of audible bandwidth on TMTFs and gap detection. 3. The influence of changes in the compressive nonlinearity. V. TEMPORAL INTEGRATION AT THRESHOLD. 1. Temporal integration in normally hearing people. 2. Temporal integration in people with cochlear hearing loss. 3. Explanations for reduced temporal integration in people with cochlear hearing loss. VI. TEMPORAL INTEGRATION AT SUPRATHRESHOLD LEVELS. VII. PERCEPTUAL CONSEQUENCES OF ABNORMAL TEMPORAL PROCESSING IN PEOPLE WITH COCHLEAR HEARING LOSS. 1. Consequences of abnormal temporal resolution. 2. Consequences of reduced temporal integration. Chapter 6. Pitch Perception and Frequency Discrimination. I. INTRODUCTION. II. THEORIES OF PITCH PERCEPTION. III. THE PERCEPTION OF THE PITCH OF PURE TONES BY NORMALLY HEARING PEOPLE. 1. The frequency discrimination of pure tones. 2. The perception of musical intervals. 3. The effect of level on pitch. IV. FREQUENCY DISCRIMINATION OF PURE TONES BY PEOPLE WITH COCHLEAR HEARING LOSS. 1. Difference limens for frequency (DLFs). 2. Frequency modulation detection limens (FMDLs). V. THE PERCEPTION OF PURE-TONE PITCH FOR FREQUENCIES FALLING IN A DEAD REGION. VI. PITCH ANOMALIES IN THE PERCEPTION OF PURE TONES. VII. THE PITCH PERCEPTION OF COMPLEX TONES BY NORMALLY HEARING PEOPLE. 1. The phenomenon of the missing fundamental. 2. Discrimination of the repetition rate of complex tones. VIII. THEORIES OF PITCH PERCEPTION FOR COMPLEX TONES. 1. The representation of a complex tone in the peripheral auditory system. 2. Spectro-temporal pitch theories. 3. The relative importance of envelope and temporal fine structure. IX. PITCH PERCEPTION OF COMPLEX TONES BY PEOPLE WITH COCHLEAR HEARING LOSS. 1. Theoretical considerations. 2. Experimental studies. X. PERCEPTUAL CONSEQUENCES OF ALTERED FREQUENCY DISCRIMINATION AND PITCH PERCEPTION. 1. Effects on speech perception. 2. Effects on music perception. Chapter 7. Spatial Hearing and Advantages of Binaural Hearing. I. INTRODUCTION. II. THE LOCALISATION OF SINUSOIDS. 1. Cues for localisation. 2. Performance of normally hearing people in localisation and lateralisation. 3. Performance of hearing-impaired people in localisation and lateralisation. III. THE LOCALISATION OF COMPLEX SOUNDS. 1. The role of transients and across-frequency comparisons. 2. Performance of normally hearing people. 3. Performance of people with cochlear hearing loss. 4. Reasons for large ITD and IID thresholds in people with cochlear hearing loss. IV. THE CONE OF CONFUSION, HEAD MOVEMENTS, AND PINNA CUES. 1. The cone of confusion. 2. The role of head movements. 3. Information provided by the pinnae. 4. Localisation using pinna cues by normal and hearing-impaired people. V. GENERAL CONCLUSIONS ON SOUND LOCALISATION. VI. THE PRECEDENCE EFFECT. 1. The precedence effect for normal hearing. 2. The precedence effect for impaired hearing. VII. BINAURAL MASKING LEVEL DIFFERENCES (MLDS). 1. MLDs for normally hearing people. 2. Mechanisms underlying MLDs. 3. MLDs for people with cochlear hearing loss. 4. Possible reasons for smaller MLDs in people with cochlear damage. VIII. HEAD SHADOW EFFECTS. 1. Benefits of head shadow for normally hearing people. 2. Benefits of head shadow for hearing-impaired people. IX. RELEASE FROM INFORMATIONAL MASKING. X. DIOTIC ADVANTAGES. XI. PERCEPTUAL CONSEQUENCES OF ABNORMAL BINAURAL AND SPATIAL HEARING IN PEOPLE WITH COCHLEAR DAMAGE. Chapter 8. Speech Perception. I. INTRODUCTION. II. THE MAGNITUDE OF THE NOISE PROBLEM. III. THE ROLE OF AUDIBILITY. 1. The Articulation Index and Speech Intelligibility Index. 2. Use of the AI or SII to predict speech intelligibility for the hearing impaired. 3. The intelligibility of speech in noise at high overall levels. 4. Comparison of detection and recognition for speech in noise. 5. The intelligibility of speech in quiet at high overall levels. 6. Simulation of hearing loss by selective filtering (frequency-dependant attenuation). 7. Simulation of hearing loss by masking. 8. Comparison of speech intelligibility for conductive and cochlear losses. 9. Conclusions on the role of audibility. IV. INFLUENCE OF DEAD REGIONS ON SPEECH PERCEPTION. V. CORRELATION BETWEEN PSYCHOACOUSTIC ABILITIES AND SPEECH PERCEPTION. VI. ASSESSING THE EFFECTS OF FREQUENCY SELECTIVITY ON VOWEL AND CONSONANT PERCEPTION. 1. Consonant perception. 2. Vowel perception. VII. INFLUENCE OF LOSS OF SENSITIVITY TO TEMPORAL FINE STRUCTURE. VIII. THE USE OF SIMULATIONS TO ASSESS THE IMPORTANCE OF PSYCHOACOUSTIC FACTORS IN SPEECH PERCEPTION. 1. Simulations of loudness recruitment combined with threshold elevation. 2. Simulations of reduced frequency selectivity. 3. Simulation of the combined effects of threshold elevation, recruitment and reduced frequency selectivity. 4. Simulation of reduced temporal resolution. IX. CONCLUSIONS. Chapter 9. Hearing Aids. I. INTRODUCTION. II. LINEAR AMPLIFICATION. 1. The difficulty of restoring audibility using linear aids. 2. Prescriptive fitting rules for linear hearing aids. III. COMPRESSION AMPLIFICATION. 1. Basic characteristics of AGC systems. 2. Varieties of AGC systems. 3. Rationales for the use of multi-band compression (and noise reduction). 4. Research on the effectiveness of multi-band syllabic compression. 5. Methods of initial fitting of hearing aids with multi-band compression. 6. Methods for fine tuning hearing aids with multi-band compression. 7. Slow-acting AGC systems. 8. Comparisons of ssslow-acting and fast-acting systems. 9. General conclusions about compression. IV. SOME GENERAL PROBLEMS WITH HEARING AIDS. 1. Inadequate gain at high frequencies. 2. Acoustic feedback. 3. Peakiness of frequency response. 4. The occlusion effect. 5. Time delays. V. METHODS FOR IMPROVING THE SPEECH-TO-NOISE RATIO. 1. Multi-channel noise reduction. 2. Directional microphones. 3. Binaural processing algorithms. VI. TRANSPOSITION AIDS FOR SEVERE AND PROFOUND HEARING LOSS. VII. COCHLEAR IMPLANTS. VIII. CONCLUDING REMARKS. Glossary. References.
£78.26
John Wiley & Sons Inc Medical Devices
Book SynopsisAddressing the exploding interest in bioengineering for healthcare applications, this book provides readers with detailed yet easy-to-understand guidance on biomedical device engineering. Written by prominent physicians and engineers, Medical Devices: Surgical and Image-Guided Technologies is organized into stand-alone chapters covering devices and systems in diagnostic, surgical, and implant procedures. Assuming only basic background in math and science, the authors clearly explain the fundamentals for different systems along with such topics as engineering considerations, therapeutic techniques and applications, future trends, and more. After describing how to manage a design project for medical devices, the book examines the following: Instruments for laparoscopic and ophthalmic surgery, plus surgical robotics Catheters in vascular therapy and energy-based hemostatic surgical devices Tissue ablation systems and the varied uses of laserTable of ContentsPREFACE xvii CONTRIBUTORS xix PART I INTRODUCTION TO MEDICAL DEVICES 1 1. Introduction 3 Martin Culjat 1.1 History of Medical Devices 3 1.2 Medical Device Terminology 6 1.3 Purpose of the Book 10 2. Design of Medical Devices 11 Gregory Nighswonger 2.1 Introduction 11 2.2 The Medical Device Design Environment 11 2.2.1 US Regulation 12 2.2.2 Differences in European Regulation 13 2.2.3 Standards 14 2.3 Basic Design Phases 15 2.3.1 Feasibility 15 2.3.2 Planning and Organization—Assembling the Design Team 16 2.3.3 When to Involve Regulatory Affairs 17 2.3.4 Conceptualizing and Review 17 2.3.5 Testing and Refinement 20 2.3.6 Proving the Concept 20 2.3.7 Pilot Testing and Release to Manufacturing 22 2.4 Postmarket Activities 25 2.5 Final Note 25 PART II MINIMALLY INVASIVE DEVICES AND TECHNIQUES 27 3. Instrumentation for Laparoscopic Surgery 29 Camellia Racu-Keefer, Scott Um, Martin Culjat, and Erik Dutson 3.1 Introduction 29 3.2 Basic Principles 31 3.3 Laparoscopic Instrumentation 34 3.3.1 Trocars 34 3.3.2 Standard Laparoscopic Instruments 37 3.3.3 Additional Laparoscopic Instruments 42 3.3.4 Specimen Retrieval Bags 44 3.3.5 Disposable Instruments 44 3.4 Innovative Applications 45 3.5 Summary and Future Applications 46 4. Surgical Instruments in Ophthalmology 49 Allen Y. Hu, Robert M. Beardsley, and Jean-Pierre Hubschman 4.1 Introduction 49 4.2 Cataract Surgery 51 4.2.1 Basic Technique 51 4.2.2 Principles of Phacoemulsification 52 4.2.3 Phacoemulsification Instruments 54 4.2.4 Phacoemulsification Systems 55 4.2.5 Future Directions 56 4.3 Vitreoretinal Surgery 56 4.3.1 Basic Techniques 56 4.3.2 Principles of Vitrectomy 57 4.3.3 Vitrectomy Instruments 58 4.3.4 Vitrectomy Systems 60 4.3.5 Future Directions 60 4.4 Other Ophthalmic Surgical Procedures 61 4.5 Conclusion 62 5. Surgical Robotics 63 Jacob Rosen 5.1 Introduction 63 5.2 Background and Leading Concepts 63 5.2.1 Human–Machine Interfaces: System Approach 65 5.2.2 Tissue Biomechanics 70 5.2.3 Teleoperation 72 5.2.4 Image-Guided Surgery 78 5.2.5 Objective Assessment of Skill 79 5.3 Commercial Systems 80 5.3.1 ROBODOC® (Curexo Technology Corporation) 80 5.3.2 daVinci (Intuitive Surgical) 83 5.3.3 Sensei® X (Hansen Medical) 84 5.3.4 RIO® MAKOplasty (MAKO Surgical Corporation) 86 5.3.5 CyberKnife (Accuray) 89 5.3.6 Renaissance™ (Mazor Robotics) 91 5.3.7 ARTAS® System (Restoration Robotics, Inc.) 92 5.4 Trends and Future Directions 93 6. Catheters in Vascular Therapy 99 Axel Boese 6.1 Introduction 99 6.2 Historic Overview 100 6.3 Catheter Interventions 102 6.4 Catheter and Guide Wire Shapes and Configurations 105 6.4.1 Catheters 105 6.4.2 Guide Wires 113 6.5 Conclusion 116 PART III ENERGY DELIVERY DEVICES AND SYSTEMS 119 7. Energy-Based Hemostatic Surgical Devices 121 Amit P. Mulgaonkar, Warren Grundfest, and Rahul Singh 7.1 Introduction 121 7.2 History of Energy-Based Hemostasis 122 7.3 Energy-Based Surgical Methods and Their Effects on Tissues 125 7.3.1 Disambiguation 126 7.3.2 Thermal Effects on Tissues 127 7.4 Electrosurgery 128 7.4.1 Electrosurgical Theory 128 7.4.2 Cutting and Coagulation Techniques 130 7.4.3 Equipment 131 7.4.4 Considerations and Complications 133 7.5 Future Of Electrosurgery 134 7.6 Conclusion 135 8. Tissue Ablation Systems 137 Michael Douek, Justin McWilliams, and David Lu 8.1 Introduction 137 8.2 Evolving Paradigms in Cancer Therapy 138 8.3 Basic Ablation Categories and Nomenclature 140 8.4 Hyperthermic Ablation 140 8.5 Fundamentals of In Vivo Energy Deposition 141 8.6 Hyperthermic Ablation: Optimizing Tissue Ablation 143 8.7 Radiofrequency Ablation 144 8.8 RFA: Basic Principles 145 8.9 RFA: In Vivo Energy Deposition 145 8.10 Optimizing RFA 147 8.11 Other Hyperthermic Ablation Techniques 149 8.11.1 Microwave Ablation (MWA) 149 8.11.2 MWA: Basic Principles 149 8.11.3 MWA: In Vivo Energy Deposition 151 8.11.4 Optimizing MWA 152 8.12 Laser Ablation 153 8.13 Hypothermic Ablation 154 8.13.1 Cryoablation: Basic Concepts 154 8.13.2 Cryoablation: In Vivo Considerations 154 8.13.3 Optimizing Cryoablation Systems 154 8.14 Chemical Ablation 157 8.15 Novel Techniques 158 8.15.1 High Intensity Focused Ultrasound (HIFU) 158 8.15.2 Irreversible Electroporation (IRE) 159 8.16 Tumor Ablation and Beyond 160 9. Lasers in Medicine 163 Zachary Taylor, Asael Papour, Oscar Stafsudd, and Warren Grundfest 9.1 Introduction 163 9.1.1 Historical Perspective 164 9.1.2 Basic Operational Concepts 165 9.1.3 First Experimental MASER (Microwave Amplification by Stimulated Emission of Radiation) 166 9.2 Laser Fundamentals 167 9.2.1 Two-Level Systems and Population Inversion 167 9.2.2 Multiple Energy Levels 167 9.2.3 Mode of Operation 169 9.2.4 Beams and Optics 171 9.3 Laser Light Compared to Other Sources of Light 174 9.3.1 Temporal Coherence 174 9.3.2 Spectral Coherence (Line Width) 175 9.3.3 Beam Collimation 177 9.3.4 Short Pulse Duration 177 9.3.5 Summary 178 9.4 Laser–Tissue Interactions 178 9.4.1 Biostimulation 178 9.4.2 Photochemical Interactions 179 9.4.3 Photothermal Interactions 180 9.4.4 Ablation 180 9.4.5 Photodisruption 181 9.5 Lasers in Diagnostics 181 9.5.1 Optical Coherence Tomography 181 9.5.2 Fluorescence Angiography 184 9.5.3 Near Infrared Spectroscopy 185 9.6 Laser Treatments and Therapy 186 9.6.1 Overview of Current Medical Applications of Laser Technology 186 9.6.2 Retinal Photodynamic Therapy (Photochemical) 188 9.6.3 Transpupillary Thermal Therapy (TTT) (Photothermal) 188 9.6.4 Vascular Birth Marks (Photocoagulation) 190 9.6.5 Laser Assisted Corneal Refractive Surgery (Ablation) 191 9.7 Conclusions 196 PART IV IMPLANTABLE DEVICES AND SYSTEMS 197 10. Vascular and Cardiovascular Devices 199 Dan Levi, Allan Tulloch, John Ho, Colin Kealey, and David Rigberg 10.1 Introduction 199 10.2 Biocompatibility Considerations 200 10.3 Materials 202 10.3.1 316L Stainless Steel 203 10.3.2 Nitinol 203 10.3.3 Cobalt–Chromium Alloys 204 10.4 Stents 204 10.5 Closure Devices 206 10.6 Transcatheter Heart Valves 208 10.7 Inferior Vena Cava Filters 212 10.8 Future Directions–Thin Film Nitinol 214 10.9 Conclusion 216 11. Mechanical Circulatory Support Devices 219 Colin Kealey, Paymon Rahgozar, and Murray Kwon 11.1 Introduction 219 11.2 History 220 11.3 Basic Principles 221 11.3.1 Biocompatibility and Mechanical Circulatory Support Devices 221 11.3.2 Hemocompatibility: Microscopic Considerations 222 11.3.3 Hemocompatibility: Macroscopic Considerations 223 11.4 Engineering Considerations in Mechanical Circulatory Support 223 11.4.1 Overview 223 11.4.2 Pump Design 225 11.4.3 Positive Displacement Pumps 225 11.4.4 Rotary Pumps 226 11.4.5 Pulsatile Versus Nonpulsatile Flow 228 11.5 Devices 228 11.5.1 The HeartMate XVE Left Ventricular Assist System 228 11.5.2 The HeartMate II Left Ventricular Assist System 231 11.5.3 Short-Term Mechanical Circulatory Support: The Intraaortic Balloon Pump 234 11.5.4 Pediatric Mechanical Circulatory Support: The Berlin Heart 237 11.6 The Future of MCS Devices 239 11.6.1 CorAide 239 11.6.2 HeartMate III 239 11.6.3 HeartWare 240 11.6.4 VentrAssist 240 11.7 Summary 240 12. Orthopedic Implants 241 Sophia N. Sangiorgio, Todd S. Johnson, Jon Moseley, G. Bryan Cornwall, and Edward Ebramzadeh 12.1 Introduction 241 12.1.1 Overview 241 12.1.2 History 243 12.2 Basic Principles 244 12.2.1 Optimization for Strength and Stiffness 245 12.2.2 Maximization of Implant Fixation to Host Bone 250 12.2.3 Minimization of Degradation 251 12.2.4 Sterilization of Implants and Instrumentation 253 12.3 Implant Technologies 253 12.3.1 Total Hip Replacement 254 12.3.2 Technology in Total Knee Replacement 263 12.3.3 Technology in Spine Surgery 268 12.4 Summary 272 PART V IMAGING AND IMAGE-GUIDED TECHNIQUES 275 13. Endoscopy 277 Gregory Nighswonger 13.1 Introduction 277 13.2 Ancient Origins 278 13.3 Modern Endoscopy 280 13.3.1 Creating Cold Light 280 13.3.2 Introduction of Rod-Lens Technology 280 13.4 Principles of Modern Endoscopy 283 13.4.1 Optics 284 13.4.2 Mechanics 284 13.4.3 Electronics 284 13.4.4 Software 285 13.5 The Imaging Chain 285 13.5.1 Light Source (1) 286 13.5.2 Telescope (2) 286 13.5.3 Camera Head (3) 287 13.5.4 Camera CCU (4) 287 13.5.5 Video Cables (5) 287 13.5.6 Monitor (6) 287 13.5.7 Image Management Systems (7) 288 13.6 Endoscopes for Today 288 13.6.1 Rigid Endoscopes—Designs to Enhance Functionality 289 13.6.2 Less Traumatic Ureterorenoscopes 290 13.6.3 Advances in Flexible Endoscope Design 291 13.6.4 Broader Functionality with New Technologies 294 13.6.5 Enhancing Video Capabilities 299 13.7 Endoscopy’s Future 301 14. Medical Ultrasound Devices 303 Rahul Singh and Martin Culjat 14.1 Introduction 303 14.2 Basic Principles of Ultrasound 304 14.2.1 Basic Acoustic Physics 304 14.2.2 Reflection and Refraction 307 14.2.3 Attenuation 307 14.2.4 Piezoelectricity 308 14.2.5 Ultrasound Systems 310 14.2.6 Resolution and Bandwidth 312 14.2.7 Beam Characteristics 314 14.3 Ultrasound Transducer Design 316 14.3.1 Piezoelectric Material 317 14.3.2 Backing Layers and Damping 318 14.3.3 Matching Layers 318 14.3.4 Mechanical Focusing 319 14.3.5 Electrical Matching 320 14.3.6 Sector Scanners 320 14.3.7 Array Transducers 322 14.3.8 Transducer Array Fabrication 325 14.3.9 Regulatory Considerations 327 14.4 Applications of Medical Ultrasound 329 14.4.1 Image Guidance Applications 330 14.4.2 Intravascular and Intracardiac Applications 332 14.4.3 Intraoral and Endocavity Applications 333 14.4.4 Surgical Applications 334 14.4.5 Ophthalmic Ultrasound 335 14.4.6 Doppler and Doppler Applications 336 14.4.7 Therapeutic Applications 336 14.5 The Future of Medical Ultrasound 338 15. Medical X-ray Imaging 341 Mark Roden 15.1 Introduction 341 15.2 X-ray Physics 342 15.2.1 Photon Interactions with Matter 342 15.2.2 Clinical Production of X-rays 343 15.2.3 Patient Dose Considerations 346 15.3 Two-Dimensional Image Acquisition 348 15.4 Image Acquisition Technologies and Techniques 351 15.4.1 Film 351 15.4.2 Computed Radiography 354 15.4.3 Digital Radiography 358 15.4.4 Clinical Applications of 2D X-ray Techniques 360 15.5 Basic 2D Processing Techniques 361 15.5.1 Independent Pixel Operations 362 15.5.2 Grouped Pixel Operations 363 15.5.3 Image Transformation Operations 366 15.6 Real-Time X-ray Imaging 367 15.6.1 Fluoroscopy Technology 367 15.6.2 Angiography 370 15.7 Three-Dimensional X-ray Imaging 372 15.8 Conclusion 373 16. Navigation in Neurosurgery 375 Jean-Jacques Lemaire, Eric J. Behnke, Andrew J. Frew, and Antonio A. F. DeSalles 16.1 Basics of Neurosurgery 375 16.1.1 General Technical Issues in Neurosurgery 375 16.1.2 Instrumentation in Neurosurgery 376 16.1.3 Complications 377 16.1.4 Functional Neurosurgery 378 16.1.5 Stereotactic Neurosurgery 378 16.1.6 Neuroimaging for Neurosurgery 379 16.2 Introduction to Neuronavigation 381 16.3 Neuronavigation Systems 381 16.3.1 The Tracking System 382 16.3.2 The Display Unit 383 16.3.3 The Control Unit 385 16.4 Implementation of Neuronavigation 386 16.4.1 Surgical Planning 386 16.4.2 Patient Registration 387 16.4.3 Navigation 389 16.5 Augmented Reality and Virtual Reality 390 16.6 Summary/Future 391 REFERENCES 395 INDEX 425
£121.46
