Medical research Books

Book Synopsis''Her stories have the power to transform your life'' Lori Gottlieb, bestselling author of Maybe You Should Talk to Someone ''Radically changes the way we think about mental illness, pleasure, pain, reward and stress'' Daniel Levitin, bestselling author of The Organized MindTHE NEW YORK TIMES AND SUNDAY TIMES BESTSELLER We are a wired generation. In these fast-paced times we are constantly bombarded by high-reward, high-dopamine stimuli. From texting to social media, food to drugs, gambling to shopping, we have become addicted to fleeting and distracting pleasures that are making us sick.In Dopamine Nation, psychiatrist and bestselling author Dr Anna Lembke reveals why our relentless pursuit of pleasure leads to pain and what we can do about it. Bringing together cutting-edge neuroscience with the gripping real life experiences from her clinical practice, Lembke explores how contentment and connTrade ReviewAnna Lembke's stories of guiding people to find a healthy balance between pleasure and pain have the power to transform your life -- Lori Gottlieb, bestselling author of Maybe You Should Talk to SomeoneBrilliant . . . No matter what you might find yourself over-indulging in-from the internet to food to work to sex-you'll find this book riveting, scary, cogent, and cleverly argued. Lembke weaves patient stories with research, in a voice that's as empathetic as it is clear-eyed -- Beth Macy, bestselling author of DopesickRadically changes the way we think about mental illness, pleasure, pain, reward, and stress. Turn toward it. You'll be happy you did -- Daniel Levitin, bestselling author of The Organized Mind and Successful Aging[An] eye-opening survey on pleasure-seeking and addiction . . . Readers looking for balance will return to Lembke's informative and fascinating guidance. * Publishers Weekly, starred review *fascinating case histories, and a sensible formula for treatment. * Kirkus Reviews *Dr Anna Lembke is a whiz on why we get hooked on things - and how we can enjoy pleasurable things in healthier doses * Guardian *

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Book SynopsisA clinical psychiatrist explores the effects of DMT, one of the most powerful psychedelics known.Trade Review"Fascinating and provocative. A remarkable exploration of the boundaries of science and consciousness itself." * Rupert Sheldrake, author of The Presence of the Past *"Rick Strassman's pioneering research work with DMT, a natural psychedelic drug used by Amazonian Indians, raises fascinating questions about the neurochemical basis of experience and the feasibility of conducting human research with mind-altering drugs in a university medical center. Truly adventurous reading!" * Andrew Weil, M.D., author of Spontaneous Healing *"This book is essential reading for anyone with an interest in the mind, philosophy, the nature of reality, and spirituality." * Karl Jansen, M.D., Ph.D. *"DMT: The Spirit Molecule points the way beyond the present impasse of the reigning 'drug abuse' paradigm." * Jonathan Ott, author of The Age of Entheogens and Hallucinogenic Plants of North America *"The most extensive scientific study of the mental and perceptual effects of a psychedelic drug since the 1960s." * Ralph Metzner, Ph.D., author of Ayahuasca: Consciousness and the Spirits of Nature *"Strassman's important research contributes to a growing awareness that we inhabit a multi-dimensional universe." * John Mack, MD Professor of Psychiatry, Harvard Medical School, author of Abduction and Passport to t *"Strassman raises vital questions about the origin of spiritual experiences and the nature of consciousness." * Larry Dossey MD, author of Reinventing Medicine, and Healing Words; Executive Editor, Alternative Th *"DMT: The Spirit Molecule is a fascinating journey into the research of psychedelics. . . . The questions and possible explanations about the endogenous presence of DMT that he raises not only enlarge the discussion about psychedelics but also expand our understanding of the nature of consciousness." * Jule Klotter, Townsend Letter for Doctors & Patients - July, 2001 *"This book will be of profound interest to . . . anyone with a deep interest in the study of consciousness, visionary states and/or psycho-pharmacology." * J. P. Harpignies, Lapis *"Strassman's psychonauts regularly found themselves hurtled into alien laboratories, high-tech nurseries, and Day-Glo hieroglyphic hypercubes." * Erik Davis, The Village Voice *"DMT: the Spirit Molecule is an enriching journey into one scientist's courageous attempt to solve a bit more of the brain/mind/spirit mystery at the center of human existence." * Vicki Ecker, UFO Magazine, December-January 2002 *"What you will find is a thoughtful, well-written report about another of life's mysteries." * James Dekorne, Fortean Times, November 2001 *"Strassman's research was an important step, one that will potentially illuminate the path for future researchers and volunteers alike, and this book is a great contribution to the ongoing dialogue surrounding psychedelics." * Scotto, Trip, Fall 2001 *"This is probably the most thorough book on the psychedelic, DMT--its history, chemistry, uses (legal and illegal), and its effects. This is a very compelling, thoughtful book, written by a scrupulous scientist with the soul of a meditator." * The Book Reader, Spring/Summer 2002 *"The account of the project is an excellent inside view of human drug studies, especially those with psychedelics." * Paul Von Ward, The AHP Perspective, June/July 2002 *"This book is a highly readable, intriguing, provocative description of Rick Strassman's theories and research concerning the effects of DMT." * Alissa Hirshfeld-Flores, M.A., LMFT, The American Journal of Psychiatry, August 2002 *"Rick Strassman's experimentation with the psychoactive substance DMT is taking up where Leary's 1950/60's LSD experiments stopped." * Rev. Dr. S. D'Montford, New Dawn, Jan-Feb 2006 *"[Strassman's] account, written more for the layman than the specialist, is ground-breaking, and raises the interesting question as to what is truly a psychedelic experience." * Peter Fenwick, The Scientific and Medical Network, Summer 2007 *"Near-death experiences. Alien abductions. Lucid dreams. Even gods and goddesses. Try DMT for an explanation and it all holds together. It's brain chemistry. It's neuropharmacology. It's quite possibly other realms. Whatever it is, it's the new frontier, a closer examination of consciousness, and it's very, very exciting!" * betaphilings.com, Dec 2008 *"[Strassman] is a gifted writer and makes scientific jargon easy to read. The book gives very interesting examples of what the volunteers envisioned and how they felt throughout the experiences. . . . It is important for us as a society to look at legal, controlled, and supervised experimentation with psychoactive drugs with open minds, and with eventual scientific benefit in mind." * Levi Cox, FLC Law and Society Science & Metaphysics Blog, Feb 2009 *"Fascinating stuff! If this kind of thing interests you then pick up this book today." * Loretta Nall, blog by former Alabama Gubernatorial Candidate, June 2009 *"In the end, I felt the most important element of the book was the contextualization of the questions most important in psychedelic research. Strassman keenly recognizes and extrapolates the areas that appear to be most vital in the further study and theory of psychedelics." * The Psychedelic Press UK, Sept 2009 *“Highly readable, intriguing, provocative. . . . [An] intellectually courageous book. . . . Will be of great use both to researchers and clinicians, as well as to laypeople.” * American Journal of Psychiatry, 2002 *“A dazzling journey through psychedelic drug experimentation and a tantalizing peek into a new model of how the brain and mind work. Strassman’s research points toward a physiological basis for spirit and its interaction with the human body; his data suggests that our brain chemistry allows us access to other realms of existence just when we need it most, and his story recounts both the dangers and promises of entering this brave new world.” * Bruce Greyson, Editor, Journal of Near-Death Studies *Table of ContentsDMT: The Spirit Molecule A Doctor's Revolutionary Research into the Biology of Near-Death and Mystical Experiences Acknowledgments Introduction Prologue: First Sessions Part I: The Building Blocks Part II: Conception and Birth Part III: Set, Setting, and DMT Part IV: The Sessions Part V: Taking Pause Part VI: What Could and Might Be

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Book Synopsis Ben Goldacre’s wise and witty bestseller, shortlisted for the Samuel Johnson Prize, lifts the lid on quack doctors, flaky statistics, scaremongering journalists and evil pharmaceutical corporations. Trade Review‘From an expert with a mail-order PhD to debunking the myths of homeopathy, Ben Goldacre talking the reader through some notable cases and shows how to you don’t need a science degree to spot “bad science” yourself.’ Independent (Book of the Year) ‘His book aims to teach us better, in the hope that one day we write less nonsense.’ Daily Telegraph (Book of the Year) ‘For sheer savagery, the illusion-destroying, joyous attack on the self-regarding, know-nothing orthodoxies of the modern middle classes, “Bad Science” can not be beaten. You’ll laugh your head off, then throw all those expensive health foods in the bin.’ Trevor Philips, Observer (Book of the Year) ‘Unmissable…laying about himself in a froth of entirely justified indignation, Goldacre slams the mountebanks and bullshitters who misuse science. Few escape: drug companies, self-styled nutritionists, deluded researchers and journalists all get thoroughly duffed up. It is enormously enjoyable.’ The Times (Book of the Year)

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Book SynopsisThe story of the search for p53--the most important gene in medicine.All of us have lurking in our DNA a most remarkable gene: it is known simply as p53 and its job is to protect us from cancer. p53: The Gene that Cracked the Cancer Code tells the story of the discovery of the gene and of medical science''s mission to unravel its mysteries and get to the heart of what happens in our cells when they turn cancerous. When all is well, this gene constantly scans our cells to ensure that when they grow and divide as part of the routine maintenance of our bodies, they do so without mishap. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. Cancer cannot develop unless p53 itself is damaged or handicapped by some other fault in the system. Not surprisingly, p53 is the most studied single gene in history. Through the personal acTrade ReviewMore than any textbook, article, or lecture could, this book offers a sip of contagious enthusiasm and a conviction that scientists will eventually “crack the cancer code" * Science *Armstrong’s book is genuinely engrossing on many levels, and the story is very well told. It has considerable depth, yet sufficient clarity to be able to reach a wide audience ... a highly readable, well-written and crafted book. * Cell *A succinct, accessible study of humanity's genetic bulwark against cancer. * Nature *One of the best accounts I’ve read of how science is actually performed. -- Peter Forbes * The Guardian *Armstrong paints a very human picture ... Not only does Armstrong make p53 understandable but she also sheds light on the scientific method. In an age of government austerity, highlighting the importance of scientific research is also a gift. * The Lancet *Ms. Armstrong¹s book comes alive in the sections where she explores cancer¹s human toll, including the devastating experience of families with rare genetic mutations, such as Li-Fraumeni syndrome, which leaves children of parents with a faulty gene vulnerable to cancer at almost any age. She also captures the excitement of researchers as they come upon eureka moments. * Wall Street Journal *Table of ContentsPreface Chapter 1: Flesh of our Own Flesh Chapter 2: The Enemy Within Chapter 3: Discovery Chapter 4: Unseeable Biology Chapter 5: Cloning the Gene Chapter 6: A Case of Mistaken Identity Chapter 7: A New Angle on Cancer Chapter 8: p53 Reveals its True Colours Chapter 9: Master Switch Chapter 10: ‘Guardian of the Genome’ Chapter 11: Of Autumn Leaves and Cell Death Chapter 12: Of Mice and Men Chapter 13: The Guardian’s Gatekeeper Chapter 14: The Smoking Gun Chapter 15: Following the Fingerprints Chapter 16: Cancer in the Family Chapter 17: The Tropeiro Connection? Chapter 18: Jekyll and Hyde Chapter 19: Cancer and Ageing: A Balancing Act Chapter 20: The Treatment Revolution Dramatis Personae Glossary Notes on Sources Acknowledgements Index

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Book Synopsis'Louise is a voice you can really trust. I've learnt so much from her and now you can too.' - Holly Willoughby 'Dr Louise is a miracle worker' - Lorraine Kelly 'Louise is my No. 1 go-to when it comes to anything menopause and this book is perfect for when I'm worried about anything.'- Alison Hammond 'Louise Newson is wonderful... a real expert in her field.' - Joe WicksYour complete, expert, evidence-based guide to the perimenopause and menopause. Dr Louise Newson is fast becoming the leading medical expert on hormone health. This revised and expanded edition of her bestselling book has all the information and advice you need to understand the impact of low hormone levels on your perimenopause symptoms as well as on your future health post-menopause. There's an up-to-date guide to HRT doses, how to deal with HRT availability fluctuations, new research on testosterone and its benefits bey

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Book SynopsisThis book demonstrates how qualitative methods can be used to address research issues pertinent to mental health practice and psychotherapy. With contributions from leading researchers, the book examines how to review and appraise existing qualitative literature, how to choose the most appropriate method, and how to approach ethical issues.Trade Review“In a field that at times feels dominated by obfuscating jargon and a cult-like zeal, the editors have produced an accessible, illuminating text that will be of great value to those wishing to gain an introduction to this essential and developing area of mental health research.” (The British Journal of Psychiatry, 1 May 2012) "David Harper and Andrew Thompson’s book Qualitative Research Methods in Mental Health and Psychotherapy provides a reference for students and practitioners who are using qualitative research to explore topics related to mental health. The book provides a rich and comprehensive text, with contributions from specialized authors on a number of key themes and research methods relevant to qualitative research. Despite being specifically aimed at those researching mental health issues, this text would be useful for any student or practitioner who wishes to get to grips with ‘big q research’..." (Feminism and Psychology, 2013) “Since receiving this book for review, I have found myself repeatedly recommending it to fellow doctoral researchers from a range of professional backgrounds, at all stages of candidature. I do so because, in my opinion, this book addresses, in an accessible, clear, yet thorough manner, the issues which all students and practitioner-researchers face in aspiring to produce high quality, creative, qualitative research in mental health and psychotherapy.” (QMiP Bulletin Issue 15, Spring 2013) Table of ContentsAbout the Contributors. Acknowledgements. PART I Getting Started. 1 Introduction (Andrew R. Thompson and David Harper). 2 Identifying and Synthesizing Qualitative Literature (Rachel L. Shaw). 3 Ethical Issues in Qualitative Mental Health Research (Andrew R. Thompson and Eleni Chambers). 4 Participation and Service User Involvement (Alison Faulkner). 5 Qualitative Data Collection: Asking the Right Questions (Hannah Frith and Kate Gleeson). 6 Qualitative Methods for Studying Psychotherapy Change Processes (Robert Elliott). 7 Choosing a Qualitative Research Method (David Harper). PART II Methods. 8 Interpretative Phenomenological Analysis in Mental Health and Psychotherapy Research (Michael Larkin and Andrew R. Thompson). 9 Existentialist-Informed Hermeneutic Phenomenology (Carla Willig and Abigail Billin). 10 Grounded Theory Methods for Mental Health Practitioners (Alison Tweed and Kathy Charmaz). 11 Discourse Analysis (Eugenie Georgaca and Evrinomy Avdi). 12 Narrative Psychology (Michael Murray and Sally Sargeant). 13 Ethnomethodology/Conversation Analysis (Mark Rapley). 14 Q Methodological Research in Mental Health and Psychotherapy (Wendy Stainton Rogers and Phillip O. Dyson). 15 Thematic Analysis (Helene Joffe). PART III Establishing Good Quality Qualitative Research in Mental Health. 16 In Pursuit of Quality (Liz Spencer and Jane Ritchie). 17 Emerging Issues and Future Directions (David Harper and Andrew R. Thompson). Index.

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Book SynopsisThis handbook is a definitive, up-to-date, and succinct text covering the legislative requirements, scientific foundations, and clinical good practice necessary for clinical, academic, and healthcare research.Trade ReviewThe Oxford Handbook of Clinical and Healthcare Research packs a lot of information into a literally hand-sized ... book, with precise writing." * Norman M. Goldfarb, Journal of clinical research best practises *A unique handbook that covers all the stages of clinical research along with a clear description of the regulations / processes that current researchers need to comply with. This truly addresses a much needed gap in the various research handbooks. * Dr Puja Myles, Associate Professor Health Protection and Epidemiology; Nottingham University *Table of Contents1. Research - How and Why ; 2. Navigating Research Methods: Basic concepts in biostatistics and epidemiology ; 3. Navigating Research Methods: Quantitative and clinical / epidemiological methods ; 4. Navigating Research Methods: Qualitative methods ; 5. Navigating Research Methods: Evidence Based Medicine (EBM) ; 6. Navigating Research Methods: Critical ap-praisal ; 7. Navigating Research Methods: Clinical Audit ; 8. Setting the scene and ICH-GCP in clinical and healthcare research ; 9. Informed consent in a research setting ; 10. Ethics of clinical and healthcare research: general considerations, Mental Capacity Act, Human Tissue Act ; 11. Role and Responsibilities: Investigators and Research Team ; 12. Role and Responsibilities: Sponsor ; 13. Monitoring ; 14. Clinical Trial Design ; 15. Clinical Trial Protocols: Study Protocol ; 16. Data Capture Tools: Case Report Form (CRF) ; 17. Clinical Trial Supplies: IMPs ; 18. IMP Accountability ; 19. Safety Reporting ; 20. Data management ; 21. Research Project Management ; 22. Essential Documents ; 23. Archiving ; 24. Audits and Inspections ; 25. Fraud and Misconduct ; 26. Authorship ; 27. Publication process ; 28. Start-up toolkit: from funding an idea, through implementation, to achieving an impact

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Book SynopsisStanislav Grof’s first 17 years of research into nonordinary states of consciousness induced by LSD and other psychedelics led to a revolutionary understanding of the human psyche. His research was the impetus behind a vastly expanded cartography of the unconscious, including two new realms still unacknowledged by official academic circles--the perinatal domain, which holds memories of the various stages of birth, and the transpersonal domain, which mediates experiential identification with other species and mythic figures, visits to archetypal realms, access to past life memories, and union with the cosmic creative principle. The research presented in this book provides a map of the psyche that is essential for understanding such phenomena as shamanism and near death experiences as well as other nonordinary states of consciousness. This map has led to the development of important new therapies in psychiatry and psychology for treating mental conditions often seen as disease and therefore suppressed by medication. It also provides a new threshold to understanding and entering the numinous realm of spirit.Trade Review“The most significant development in the recent history of depth psychology, and the most important advance in the field since Freud and Jung themselves, has been the work of Stanislav Grof.” * Richard Tarnas, Ph.D., author of The Passion of the Western Mind *“A breakthrough work.” * Jean Houston, Ph.D., coauthor of The Varieties of Psychedelic Experience *“Stanislav Grof is the undisputed world authority on LSD and the human psyche, and this book provides the best cartography of consciousness for understanding the profound impact of entheogens on the mind.” * Alex Grey, artist and author of Sacred Mirrors and Transfigurations *“Dr. Stanislav Grof's LSD: Doorway to the Numinous is an extraordinary alchemical text that overturns many commonly held beliefs about the nature of individual identity and consciousness. Based on his 2,500 clinical sessions using LSD as a therapeutic tool before the substance was interdicted, Grof's book explores the vast dimensions of inner experience that have been ignored and marginalized by the mainstream. He also provides a theoretical framework for understanding these amazing experiences that synthesizes Freudian and Jungian insights into the dark matter of the unconscious and the primal drives that secretly impel us to act. A must-read for all serious students of consciousness.” * Daniel Pinchbeck, author of 2012: The Return of Quetzalcoatl and Breaking Open the Head *“I know of no work that so well incorporates the findings of Freud, Jung, and Rank, adding fresh insights that the methods of these psychotherapists could never have achieved. It certainly goes beyond Freud. It brings new clarification to Jung. It throws new light on the topic of death and resurrection symbolism, as well as on religious imagery. I do not doubt that others working in this field will find Dr. Grof's discoveries a basis for a whole new strategy of research.” * Joseph Campbell, author of The Hero with a Thousand Faces, The Masks of God, and Myths to Live By *“Stanislav Grof ’s research is the most important contribution to personality theory in several decades.” * Abraham Maslow, Ph.D., psychologist, cofounder of Humanistic and Transpersonal Psychology, and autho *“An exceptionally clear and readable introduction to the evolving psychology of the spirit--transpersonal psychology--that is one of the most exciting developments of our times. Grof is far and away one of the leading scientists exploring this field.” * Charles Tart, Ph.D., psychologist and author of States of Consciousness, PSI: Scientific Studies of *“Dr. Grof's studies of the mystical experience in LSD therapy represent an extremely valuable scientific approach to consciousness research from which many people can benefit.” * Chogyam Trungpa Rinpoche, Tibetan lama and author of Born in Tibet, Spiritual Materialism, and Medit *“Grof has had far and away more experience in psychedelic research than anyone else and has come up with the most comprehensive and helpful framework for interpreting the data in this bewildering area.” * Huston Smith, Ph.D., author of The World’s Religions and Beyond the Post-Modern Mind *“Grof marshals an impressive array of data and speculation in support of the timely demand that Western science acknowledge consciousness and its many nonordinary states.” * Richard Alpert (Ram Dass), Ph.D., psychologist, spiritual teacher, and author of Be Here Now, Grist *“A fascinating journey through previously uncharted realms of the psyche guided by one of the world’s foremost consciousness researchers. A remarkable account of the extraordinary depths of the human psyche.” * Frances Vaughan, Ph.D., psychologist and author of Awakening Intuition and The Inward Arc *" . . . Grof's engrossing state-of-the-science overview argues convincingly that continued LSD reserach will help patients, parents, policymakers, and even spiritual seekers." * Publishers Weekly, Feb 2009 *"Dr. Grof's efforts should be lauded and highly commended in the scientific and medical community. His clinical research is courageous and luminous to anyone who is conscious of the body's metaphysiology and higher energy dynamics. This field of research is as important to the human animal as molecular scientific inquiry into the etiology of neoplasias." * Dr. Ron Shane, reviewer, April 2009 *"Dr. Grof has helped to give us new ways of seeing the world . . . He has opened a link between the psyche and the spirit." * Nexus New Times Magazine, Sept/Oct 2009 *"For any serious student of psychedelics or psychology, this is an important read that should not be ignored. In terms of building a foundation for the future of the psychedelic movement and finding a place for psychedelics in society, LSD:Doorway to the Numinous is without question the text. Authoritative, insightful, and self-aware." * Psychedelic Press, UK, Feb 2010 *Table of Contents Acknowledgments Preface 1 General Introduction The LSD Controversy LSD and Its Effects in Human Beings Empirical Basis for a New Theoretical Framework Heuristic Value of LSD Research 2 Abstract and Aesthetic Experiences in LSD Sessions 3 Psychodynamic Experiences in LSD Sessions COEX Systems (Systems of Condensed Experience) Origin and Dynamics of COEX Systems Manifestation of COEX Systems in LSD Sessions Dynamic Interaction between the COEX Systems and Environmental Stimuli 4 Perinatal Experiences in LSD Sessions Perinatal Matrix I. Primal Union with the Mother (Intrauterine Experience before the Onset of Delivery) Perinatal Matrix II. Antagonism with the Mother (Contractions in a Closed Uterine System) Perinatal Matrix III. Synergism with the Mother (Propulsion through the Birth Canal) Perinatal Matrix IV. Separation from the Mother (Termination of the Symbiotic Union and Formation of a New Type of Relationship) Significance of Basic Perinatal Matrices in LSD Psychotherapy 5 Transpersonal Experiences in LSD Sessions Experiential Extension within the Framework of “Objective Reality” Temporal Expansion of Consciousness • Embryonal and Fetal Experiences • Ancestral Experiences • Collective and Racial Experiences • Phylogenetic (Evolutionary) Experiences • Past-Incarnation Experiences • Precognition, Clairvoyance, Clairaudience, and “Time Travels” Spatial Expansion of Consciousness • Ego Transcendence in Interpersonal Relationships and the Experience of Dual Unity • Identification with Other Persons • Group Identification and Group Consciousness • Animal Identification • Plant Identification • Oneness with Life and with All Creation • Consciousness of Inorganic Matter • Planetary Consciousness • Extraplanetary Consciousness • Out-of-Body Experiences, Traveling Clairvoyance and Clairaudience, “Space Travels,” and Telepathy Spatial Constriction of Consciousness • Organ, Tissue, and Cellular Consciousness Experiential Extension beyond the Framework of “Objective Reality” • Spiritistic and Mediumistic Experiences • Experiences of Encounters with Suprahuman Spiritual Entities • Experiences of Other Universes and Encounters with Their Inhabitants • Archetypal Experiences and Complex Mythological Sequences • Experiences of Encounters with Various Deities • Intuitive Understanding of Universal Symbols • Activation of the Chakras and Arousal of the Serpent Power (Kundalini) • Consciousness of the Universal Mind • The Supracosmic and Metacosmic Void Significance of Transpersonal Experiences in LSD Psychotherapy Transpersonal Experiences and Contemporary Psychiatry 6 Multidimensional and Multilevel Nature of the LSD Experience Environmental Stimuli and Elements of the Setting Personality of the Therapist and the Therapeutic Situation Present Life Situation Past Life History Early Childhood and Infancy Biological Birth and the Perinatal Period Embryonal and Fetal Existence Transindividual (Transpersonal and Transhuman) Sources Epilogue The Psychedelic Research Renaissance--A Review of Recent Psychedelic Psychotherapy Research by L. Jerome, Ph.D., Valerie Mojeiko, and Rick Doblin, Ph.D. Notes Index About the Author

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Book SynopsisHypotheses are fundamental to all sciences, including medicine. They play a critical role in motivating the development of science, since interesting and important hypotheses foster the diversity and debate upon which the scientific process depends. It is necessary to learn and understand how to assess a process, realise and discuss details and consequently launch a hypothesis. This book offers a number of novel, non-mainstream hypotheses in various states of development from authors with relevant expertise and experience.

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Book SynopsisSarcoidosis is a multisystem granulomatous disease of unknown etiology. It can occur at all ages, with the incidence peaking at 20 to 40 years. This book reviews the epidemiology, etiology, pathology, clinical manifestations, diagnosis and management strategies of sarcoidosis, while highlighting recent studies that have provided new insights into this unique and debilitating disease. The authors also specifically point out the urological manifestations of sarcoidosis to avoid misdiagnoses and to provide early intervention.

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Book Synopsis Inspire your students to be theoretical thinkers, innovative advocates, and agents for change.Focused on cultivating the next generation of scholars, this highly respected classic demystifies theory, charts strategies to use in developing and advancing theory, and provides tools and best practices in evaluating progress in the discipline. Based on the feedback of nursing students, this edition was updated to be more accessible without losing the necessary rigor to foster critical thinking. Meleis provides a developmental and historical review of theoretical nursing and helps readers develop analytic skills and integrate knowledge into a coherent whole. By embarking on the journey of nursing theory, practicing nurses will find ways to improve everyday practice, as well as develop theories that capture their expertise.Highlights of the Sixth EditionKey Topics Paradigms that influenced nursing thought, such as feminism

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Book SynopsisTrade Review...the book has much to commend it to qualifying practitioners, their tutors and practice educators.—The British Journal of Social Work...[the authors] offer credible practice-researchable examples from social work, nursing, physical therapy, education, and other practice contexts and the application of multiple methods to answer questions that emanate from those fields of practice. How do they know all this stuff?—Journal of Social WorkTable of ContentsPreface1. An Introduction to Practitioner Research2. Orientation3. Focusing4. Planning5. Data Collection6. Analysis and Conclusion7. Design and Innovation8. Documentation and PresentationAppendix. Using SourcesIndex

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Book SynopsisAt a time when medicine is a highly sought-after career for Indian women, it is hard to imagine what it was like for the pioneers. The story of how firmly they were bound in fetters of family, caste and society, and how fiercely they fought to escape, needs to be told. In Lady Doctors, Kavitha Rao unearths the extraordinary stories of six women from the 1860s to the 1930s, who defied the idea that they were unfit for medicine by virtue of their gender. From Anandibai Joshi, who broke caste rules by crossing an ocean, to Rukhmabai Raut, who escaped a child marriage, divorced her husband and studied to be a doctor; from Kadambini Ganguly, who took care of eightchildren while she worked, to child widow Haimabati Sen, who overcame poverty and hardship-these women had a profound and lasting impact. And in their forgotten lives lie many lessons for modern women. In truth, the compelling stories of these radical women have been erased from our textbooks and memories, because histories have mostly been written by men, about men. In an immensely readable narrative, and with impeccable research, Lady Doctors rectifies this omission.

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Book SynopsisWhat if everything you know about salt is wrong? A leading cardiovascular research scientist explains how this vital crystal got a negative reputation, and shows how to lower blood pressure and experience weight loss using salt. The Salt Fix is essential reading for everyone on the keto diet!   We’ve all heard the recommendation: eat no more than a teaspoon of salt a day for a healthy heart. Health-conscious Americans have hewn to the conventional wisdom that your salt shaker can put you on the fast track to a heart attack, and have suffered through bland but “heart-healthy” dinners as a result.    What if the low-salt dogma is wrong?    Dr. James DiNicolantonio has reviewed more than five hundred publications to unravel the impact of salt on blood pressure and heart disease. He’s reached a startling conclusion: The vast majority of us don’t need t

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Book Synopsis"A rewarding read for anyone who wants to know the unvarnished truth about how science really gets done." - Financial TimesAmerican taxpayers spend $30 billion annually funding biomedical research, but over half of these studies can't be replicated due to poor experimental design, improper methods, and sloppy statistics. Bad science doesn't just hold back medical progress, it can sign the equivalent of a death sentence for terminal patients. In Rigor Mortis, Richard Harris explores these urgent issues with vivid anecdotes, personal stories, and interviews with the top biomedical researchers. We need to fix our dysfunctional biomedical system--before it's too late.

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Book SynopsisA good understanding of medical statistics is essential to evaluate medical research and to choose appropriate ways of implementing findings in clinical practice. The Oxford Handbook of Medical Statistics has been written to provide doctors and medical students with a comprehensive yet concise account of this often difficult subject. Described by readers as a ''statistical Bible'', this new edition maintains the accessibility and thoroughness of the original, and includes comprehensive updates including new sections on transitional medicine, cluster designs, and modern statistical packages. The Handbook promotes understanding and interpretation of statistical methods across a wide range of topics, from study design and sample size considerations, through t- and chi-squared tests, to complex multifactorial analyses, all using examples from published research. References and further reading are included, to allow deeper understanding on specific topics. Featuring a new chapter on how to use this book in different medical contexts, the Oxford Handbook of Medical Statistics helps readers to conduct their own research and critically appraise others'' work.Trade ReviewReview from previous edition 'I am a student of the Masters in Public Health. I just wanted to let you know that I have really enjoyed the classes you taught as well as the book that you've written (the oxford handbook of medical statistics). I found the book a breath of fresh air when revising for my exams- the explanations so clear and concise, straight to the point. Statistics really do make sense when explained like this. Thank you for providing such a useful tool.' * Alicia Rosello, King's College London *Table of Contents1: How to use the Oxford Handbook of Medical Statistics 2: Research design 3: Collecting data 4: Handling data: what steps are important 5: Presenting research findings 6: Choosing and using statistical software 7: Summarising data 8: Probability and distributions 9: Statistical tests 10: Diagnostic studies 11: Other statistical methods/topics 12: Analysing multiple observations per subject 13: Analysing multiple variables per subject 14: Meta analysis 15: Bayesian statistics 16: Glossary

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Book SynopsisCBD is the biggest word in wellness right now. This book will demystify the subject in an accessible way.Sales of products containing CBD products have skyrocketed by 99 per cent in the UK in the past two years. Used in a variety of health and beauty products, CBD is now becoming ubiquitous on the high street.CBD is an all-natural compound found in the cannabis plant. Not to be confused withTetrahydrocannabinol (THC), the psychoactive component in the plant that causes the sensation of getting high, CBD is renowned for its anti-inflammatory properties and is also used in pain-relief products.The hype is massive. But what are the facts? This book, from a leading CBD expert aims to wade through the research and explain what CBD is, conditions it can help, how it can be used and the best ways to administer it. Case studies will illustrate some of the incredible stories around CBD.

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Book SynopsisPublisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.Provides immediate help for anyone preparing a biomedical paper by givin specific advice on organizing the components of the paper, effective writing techniques, writing an effective results sections, documentation issues, sentence structure and much more. The new edition includes new examples from the current literature including many involving molecular biology, expanded exercises at the end of the book, revised explanations on linking key terms, transition clauses, uses of subheads, and emphases. If you plan to do any medical writing, read this book first and get an immediate advantage.Trade Review"In summary, Zeiger's thoroughness, combined with the clarity of the examples used to illustrate each principle of clear writing, are the book's strengths. We recommend Essentials of Writing Biomedical Research Papers to students, editors, and writers at all levels who want to master IMRAD format or learn techniques that will improve their writing."--American Medical Writers Association American Medical Writers Association 20010101Table of ContentsPreface. Credits. The Goal: Clear Writing. Section I: The Building Blocks of Writing. Chapter 1: Word Choice. Chapter 2: Sentence Structure. Chapter 3: Paragraph Structure. Section II: The Text of the Biomedical Research Paper. Chapter 4: The Introduction. Chapter 5: Materials and Methods. Chapter 6: Results. Chapter 7: Discussion. Section III: Supporting Information. Chapter 8: Figures and Tables. Chapter 9: References. Section IV: The Overview. Chapter 10: The Abstract. Chapter 11: The Title. Chapter 12: The Big Picture. Reaching the Goal: Suggestions for Writing. Revisions of Exercises. Literature Cited. Index.

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Book SynopsisTable of Contents1. Montreal Neurological Institute (MNI) Stereotaxic Space by D. Louis Collins 2. Abbreviations and List of Cortical Areas 3. Reconstructions of the Average Asymmetrical MNI Brain 4. Comments on Nomenclature and Definitions of Cortical Areas 5. Coronal Sections

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Book SynopsisTable of Contents1. Neurologic complications of pediatric congenital heart disease 2. Neurologic complications of congenital heart disease in adults 3. Neurologic complications of rheumatic fever 4. Neurologic complications of nonrheumatic valvular heart disease 5. Advances and ongoing controversies in PFO closure and cryptogenic stroke 6. Neurological complications of coronary heart disease and their management 7. Neurologic complications of heart surgery 8. Neurological complications of heart failure 9. Neurological complications of cardiomyopathies 10. Neurologic complications of myocarditis 11. Neurologic complications of infective endocarditis 12. Neurologic complications of nonbacterial thrombotic endocarditis 13. Neurologic complications of atrial fibrillation: Pharmacologic and interventional approaches to stroke prevention 14. Tachyarrhythmias and neurologic complications 15. Neurologic complications of brady-arrhythmias 16. Effects of acute neurologic disease on the heart 17. Neurologic complications of genetic channelopathies 18. Neurological complications of syncope and sudden cardiac arrest 19. Neurologic complications of cardiac arrest 20. Neurologic complications of implantable devices 21. Neurologic complications of diseases of the aorta 22. Cerebral aneurysms and cervical artery dissection: Neurological complications and genetic associations 23. Neurological complications of systemic hypertension 24. Neurologic complications of venous thromboembolism 25. Neurologic complications of cardiac disease in athletes 26. Cerebrovascular manifestations of tumors of the heart 27. Stroke in pregnancy 28. Hemodynamics in acute stroke: Cerebral and cardiac complications 29. Neurological complications of cardiovascular drugs 30. The role of biomarkers and neuroimaging in ischemic/hemorrhagic risk assessment for cardiovascular/cerebrovascular disease prevention 31. Clinical utility of echocardiography in secondary ischemic stroke prevention 32. The relationship between heart disease and cognitive impairment 33. Anxiety and psychological management of heart disease and heart surgery

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Book SynopsisTable of ContentsSECTION 1 Introduction 1. Introduction: The anterior hypothalamus 2. History of hypothalamic research: “The spring of primitive existence” 3. Anatomy and cytoarchitectonics of the human hypothalamus 4. Morphology and distribution of hypothalamic peptidergic systems 5. MRI maps, segregation, and white matter connectivity of the human hypothalamus in health 6. Magnetic resonance imaging of the hypothalamo–pituitary region 7. Resting-state functional connectivity of the human hypothalamus 8. Neurogenesis in the adult hypothalamus: A distinct form of structural plasticity involved in metabolic and circadian regulation, with potential relevance for human pathophysiology 9. Matching of the postmortem hypothalamus from patients and controls SECTION 2 The basal forebrain cholinergic system 10. Spatial topography of the basal forebrain cholinergic projections: Organization and vulnerability to degeneration 11. The diagonal band of Broca in health and disease 12. Nucleus basalis of Meynert degeneration predicts cognitive impairment in Parkinson's disease 13. Enlargement of early endosomes and traffic jam in basal forebrain cholinergic neurons in Alzheimer's disease 14. Gene and cell therapy for the nucleus basalis of Meynert with NGF in Alzheimer's disease SECTION 3 The circadian system 15. The circadian system: From clocks to physiology 16. Development of the circadian system and relevance of periodic signals for neonatal development 17. Disrupted circadian rhythms and mental health 18. Diurnal and seasonal molecular rhythms in the human brain and their relation to Alzheimer disease 19. Circadian changes in Alzheimer's disease: Neurobiology, clinical problems, and therapeutic opportunities 20. The circadian system in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy 21. Retina and melanopsin neurons 22. Melatonin and the circadian system: Keys for health with a focus on sleep 23. Melatonin receptors, brain functions, and therapies 24. Chronotherapy 25. The use of melatonin to mitigate the adverse metabolic side effects of antipsychotics SECTION 4 Bed nucleus of the stria terminalis and the fear circuit 26. Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function 27. Functional anatomy of the bed nucleus of the stria terminalis–hypothalamus neural circuitry: Implications for valence surveillance, addiction, feeding, and social behaviors 28. Roles of the bed nucleus of the stria terminalis and amygdala in fear reactions SECTION 5 Preoptic area 29. The median preoptic nucleus: A major regulator of fluid, temperature, sleep, and cardiovascular homeostasis 30. The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies 31. The intermediate nucleus in humans: Cytoarchitecture, chemoarchitecture, and relation to sleep, sex, and Alzheimer disease

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Book SynopsisTable of ContentsSection I. Introduction 1. Introduction: On brain and crime Section II. Structure and Function 2. Genetics and epigenetics of human aggression 3. Network localization of antisocial behavior in neurological patients: Evidence and implications 4. Prison and the brain 5. Forensically relevant challenging behaviours and the genetics domain 6. Social-affective functioning and learning in psychopathy 7. Amygdala connectivity and ggression 8. The "(a)moral brain": When things go wrong Section III. Brain dysfunction 9. Illicit drug use and violence 10. Child maltreatment and victimization 11. Sexual offenses and the brain 12. The risk of criminal behavior in the elderly and patients with neurodegenerative disease 13. Fetal alcohol spectrum disorders and the risk of crime Section IV. Assessment and Treatment 14. Cognition, criminal conduct, and virtual reality: Understanding and reducing offending using simulated environments 15. Added value of neurotechnology for forensic psychiatric and psychological assessment Section V. Ethics and Law 16. Neurolaw: Challenges and limits 17. Why neuroscience changes some things but not everything for the law 18. Neurotechnology to reduce recidivism: Ethical and legal challenges

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Book SynopsisTable of ContentsSection I. Introduction to Mitochondrial Diseases 1. Mitochondrial disease in neurology – Past, present, and future Section II. Most Common Neurological Manifestations of Mitochondrial Disease 2. Progressive external ophthalmoplegia 3. Mitochondrial optic neuropathies 4. Leigh syndrome 5. Stroke-like episodes in adult mitochondrial disease 6. Ataxia and spastic paraplegia in mitochondrial disease 7. Peripheral neuropathy in mitochondrial disease 8. Complex neurological and multisystem presentations in mitochondrial disease Section III. Diagnosing Mitochondrial Disease 9. Investigation of oxidative phosphorylation activity and composition in mitochondrial disease 10. Genetics of mitochondrial diseases: Current approaches for the molecular diagnosis 11. Laboratory and metabolic investigations 12. Neuroimaging in mitochondrial disease Section IV. Therapy and Future Challenges 13. Currently available therapies in mitochondrial disease 14. Reproductive options in mitochondrial disease 15. Clinical trials in mitochondrial disease 16. Blood biomarkers of mitochondrial disease – One for all or all for one? 17. Experimental therapy for mitochondrial diseases

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Book SynopsisTable of ContentsSection I. Introduction 1. The connectional anatomy of the temporal lobe 2. Anatomy of the temporal lobe: From macro to micro Section II. Structure/functions of the T Lobe, as they emerge from studies in healthy participants and brain-damaged populations 3. Music processing and amusia 4. Cortical disorders of speech processing: Pure word deafness and auditory agnosia 5. Neuroplasticity following cochlear implants 6. Components of language processing and their long-term and working memory storage in the brain 7. Cross-modal integration and plasticity in the superior temporal cortex 8. Visual mental imagery: Inside the mind’s eyes 9. The functions of the temporal-parietal junction 10. Visual objects and their colors 11. Face processing in the temporal lobe 12. The neural underpinnings of word comprehension and production: The critical roles of the temporal lobes 13. Domain-specific connectivity drives the organization of object knowledge in the temporal lobe 14. The noun-verb distinction 15. The neural correlates of abstract and concrete words 16. Acquired dyslexias following temporal lesions 17. Proper names and personal identity 18. Neural correlates of recognition and naming of famous persons and landmarks: A special role for the left anterior temporal lobe 19. The temporal lobes and memory 20. Working memory and active sampling of the environment: Medial temporal contributions 21. Amygdala function in emotion, cognition, and behavior 22. Amygdala connectivity and implications for social cognition and disorders Section III. Diseases of/in the temporal lobe 23. Neuropathology of the temporal lobe 24. Frontotemporal dementia: A unique window on the functional role of the temporal lobes 25. The temporal lobe in typical and atypical Alzheimer disease 26. Limbic encephalitis 27. Semiology, EEG, and neuroimaging findings in temporal lobe epilepsies 28. Neuropsychology of temporal lobe epilepsies 29. Surgery procedures in temporal lobe epilepsies

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Book SynopsisTable of ContentsSECTION 3. Neuropalliative Care in Specific Settings 1. Palliative care after stroke survival 2. Palliative care approaches to acute stroke in the hospital setting 3. Outpatient neuropalliative care 4. Community-based neuropalliative care SECTION 4. Neuropalliative Care for Specific Conditions 5. Palliative care in brain tumors 6. Palliative care for people with dementia 7. Palliative care in Parkinson disease and related disorders 8. Palliative care in multiple sclerosis 9. Palliative care principles in ALS 10. Pediatric neuropalliative care 11. Neonatal neuropalliative aare SECTION 5. Psychosocial Support, Ethics and Education 12. Care partner support 13. Spirituality and spiritual distress in neurologic illness 14. Neurology ethics at the end of life 15. Education in neuropalliative care

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Book SynopsisThis timely and definitive book examines the nature, scope and proper place of the Nuremberg Code in medical research. Nuremberg has not only played a pivotal role in the ethics and law of human experimentation, it is also a seminal event in the history of codes of human ethics. This book analyses Nazi medicine and its role in setting the standards for human experimentation, and traces the role the Code has played in shaping research ethics and regulation from 1947 to the present.Trade Reviewfine collection of seventeen essays, written by prominent scholars in the field ... makes me appreciate the Nuremberg Code as a radical innovation in its time and as a milestone in the development of the consent doctrine in human experimentation ... renews my respect for the importance of institutional review boards as they struggle to implement the spirit of the Nuremberg Code by ensuring proper consent and protecting subects' welfare in today's research world. * Theoretical Medicine *This laudable collection of essays does much to dispel the confusion and put the whole episode in a proper perspective for those of us who need to know ... this volume of essays is well worth reading. * Claire Gilbert Foster, King's College, London, Journal of Medical Ethics, 1995, 21 *Table of Contents1: George J. Annas and Michael A. Grodin: Introduction and Overview Part I: The Nazi Doctors and the Medical Experiments 2: Robert Proctor, Ph.D.: Nazi Doctors, Racial Medicine and Human Experimentation 3: Christian Pross, M.D.: Nazi Doctors, German Medicine and the Fight for Historical Truth 4: Eva Mozes-Kor, B.S.: The Mengele Twins and Human Experimentation: A Personal Account Part II: The Doctor's Trial and the Nuremberg Code 5: Telford Taylor, LL.B., LL.D.: Opening Statement of the Prosecution 6: Judgement and Aftermath 7: Michael A. Grodin, M.D.: Historical Origins of the Nuremberg Code Part III: The Role of Codes in International and U.S. Law 8: The Nuremberg Code Revisited: An International Overview, Sharon Perley, B.A., et al. 9: Robert Drinan S.J., J.D.: The War Crimes Trials: The Nuremberg Principles as Human Rights Protection in International Law 10: Leonard H. Glantz, J.D.: The Influence of the Nuremberg Code on United States Statutes and Regulations 11: George J. Annas, J.D., M.P.H.: The Nuremberg Code in the United States Courts: Ethics Vs. Expediency Part IV: The Nuremberg Code: Ethics and Modern Medical Research 12: Jay Katz, M.D.: The Consent Principles of the Nuremberg Code: Its Significance for Then and Now 13: Ruth Machlin, Ph.D.: Universality of the Nuremberg Code: Are Ethics Relative to Time and Geography? 14: Arthur Caplan, Ph.D.: No Comparison: The Doctor's Trial and Analogies to the Holocaust in Contemporary Bioethics Debates 15: Marcia Angell, M.D.: Editorial Responsibility: Protecting Human Rights by Restricting Publication of Unethical Research 16: Wendy K. Mariner, J.D., M.P.H.: Contemporary Therapeutic AIDS Research and the Legacy of the Nuremberg Code Conclusion 17: George J. Annas, J.D., M.P.H. and Michael A. Grodin, M.D.: Where do We Go From Here?

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Book SynopsisOver the last several decades, bioethicists have championed a bewildering variety of methods for understanding and resolving difficult ethical problems in medicine, including: principlism, wide reflective equilibrium, casuistry, feminism, virtue theory, narrative, and others. Much of this advocacy overlooks the limitations of the favored method, and also neglects the strengths found in alternative approaches.Tom Tomlinson systematically uncovers and evaluates both the strengths and limits of a variety of ethical tools, and in so doing develops a comprehensive appreciation of the roles that various methods can play in deepening our understanding of ethical problems in medicine, and in supporting well-grounded judgments about what to do. He critically evaluates each method to identify both limits and advantages, which he then illustrates through discussion of specific cases and controversies. Tomlinson not only demonstrates that there is no single method adequate to the task, but tries tTrade ReviewNo other bioethics book so adroitly combines methodological survey with critical synthesis as this one does... This book should be regarded as mandatory reading for all serious students of medical ethics. * Doody's Notes, Jan 2013 *Table of ContentsIntroduction ; Chapter 1: The Indispensability of Principles ; Chapter 2: The Limits of Principles ; Chapter 3: Putting Principles in Context: Balancing, Specification and Reflective Equilibrium ; Chapter 4: Casuistry: Ruled by Cases ; Chapter 5: Narrative Ethics: The Uses of Stories ; Chapter 6: Feminism, Context and Care ; Chapter 7: Virtue Theory ; Chapter 8: Fitting Methods to Cases

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Book SynopsisAttempting to provide editorial support to the medical and scientific publishing community, this manual presents information on ethical and legal issues, with guidelines on conflict of interest, scientific misconduct, intellectual property, and the protection of individuals' rights. It also features an international perspective on drugs.

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Book SynopsisEthics in Mental Health Research explores how ethical issues arise in mental health research and offers guidance to researchers who seek to comply with regulations while conducting research that is both ethical and scientifically credible. Case studies used throughout illustrate a variety of ethical issues and effective problem-solving strategies.Trade ReviewThis compendium of resources is a landmark contribution to the mental health field. * Joseph G. Ponterotto, PsycCritiques, Vol 53, Release 40 *This outstanding book on mental health research ethics certainly will become obligatory reading for anyone contemplating research on mental illness as well as anyone responsible for the ethical and regulatory review of such research. * Doody's Notes *Table of ContentsIntroduction: Why Focus on Mental Health Research? ; 1. Ethics and Regulatory Compliance: Competing or Complementary Approaches? ; 2. An Ethical Framework for Research ; 3. Solving Ethical Problems: Analyzing Ethics Cases and Justifying Decisions Case Study: Willowbrook Revisited ; 4. Informed Consent Case Study: Withholding information on study purpose ; 5. Decision-Making Capacity and the Involvement of Surrogates Case Study: Questionable capacity Case Study: Waiving parental permission ; 6. Thinking about Harms and Benefits Case Study: A study of suicidality with at-risk teens ; 7. Justice in Recruitment and Research Case Study: Reimbursing participants for their time in a psychotherapy trial Case Study: Biological studies of aggressive behavior in preteens ; 8. Research Questions and Study Design Case Study: The ethics of placebo controls ; 9. Protecting Privacy and Confidentiality Case Study: Confidentiality and mandatory reporting ; 10. Identifying and Managing Conflicts of Interest Case Study: Multiple illustrative vignettes

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Book SynopsisAttractively illustrated with over a hundred halftones and drawings, this volume presents a series of vibrant profiles that trace the evolution of our knowledge about the brain.Beginning almost 5000 years ago, with the ancient Egyptian study of the marrow of the skull, Stanley Finger takes us on a fascinating journey from the classical world of Hippocrates, to the time of Descartes and the era of Broca and Ramon y Cajal, to modern researchers such as Sperry. Here is a truly remarkable cast of characters. We meet Galen, a man of titanic ego and abrasive disposition, whose teachings dominated medicine for a thousand years; Vesalius, a contemporary of Copernicus, who pushed our understanding of human anatomy to new heights; Otto Loewi, pioneer in neurotransmitters, who gave the Nazis his Nobel prize money and fled Austria for England; and Rita Levi-Montalcini, discoverer of nerve growth factor, who in war-torn Italy was forced to do her research in her bedroom. For each individual, FingerTrade ReviewThis book is entertaining and informative with plenty of personal detail and insights into the working practices and conditions of some of the major contributors to what we now call neuroscience. * Advances in Clinical Neuroscience & Rehabilitation *Table of Contents1. Introduction: a voyage across time ; 2. An ancient Egyptian physician: the dawn of neurology ; 3. Hippocrates: the brain as the organ of mind ; 4. Galen: The birth of experimentation ; 5. Andreas Vesalius: the new 'human' neuroanatomy ; 6. Rene Descartes: the mind-body problem ; 7. Thomas Willis: the functional organization of the brain ; 8. Luigi Galvani: electricity and the nerves ; 9. Franz Joseph Gall: the cerebral organs of the mind ; 10. Paul Broca: Cortical localization and cerebral dominance ; 11. David Ferrier and Eduard Hitzig: the experimentalists map the cerebral cortex ; 12. Jean-Martin Charcot: clinical neurology comes of age ; 13. Santiago Ramon y Cajal: from nerve nets to neuron doctrine ; 14. Charles Scott Sherrington: the integrated nervous system ; 15. Edgar D. Adrian: coding in the nervous s#stem ; 16. Otto Loewi and Henry Dale: the discovery of neurotransmitters ; 17. Roger W. Sperry and Rita Levi-Montalcini: from neural growth to 'Split Brains' ; 18. Pioneers and discoveries in the brain sciences

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Book SynopsisInterdisciplinary inquiry has begun to receive widespread attention because of the rich, creative contributions it often generates. But a host of factors, institutional, interpersonal and intellectual, also makes undertaking such research a daunting challenge for potential scientific partners. This volume is a practical guide to the most effective avenues for collaborative and integrative research in the social, behavioural, and biomedical sciences. What is the best way to conduct research programs in these areas? How do you identify appropriate collaborators? How do you find dedicated funding streams? How do you overcome peer-review and publishing challenges? This volume presents a series of case studies of successful interdisciplinary research programs, which provide a variety of models of how best to undertake interdisciplinary research in health and human science.Trade Review"Fills a gap in the academic and practice literature. Its interdisciplinary nature is highly attractive. Prevents professional Myopia. Helps remind us that great practitioners can be terrible teachers. Every issue contains at least one useful idea. In today's publishing world that is a major accomplishment. --Harris Chaiklin, Professor, University of Maryland at Baltimore Interesting, informative, and motivationsal. The variety of subjects and perspectives . . . enhance my own latent interest in several areas of supervision and field instruction. . . . Excellent! -Donald R. Bardill, PhD, Professor, School of Social Work, Florida State University, Tallahassee "Each of this welcome volume's case studies of successful interdisciplinary collaborations related to health is not only intrinsically interesting, but also illuminates how such research can be conducted."-- Steven E. Hyman, Provost, Harvard University, and former Director, National Institute of Mental Health "Each of this welcome volume's case studies of successful interdisciplinary collaborations related to health is not only intrinsically interesting, but also illuminates how such research can be conducted."--Steven E. Hyman, Provost, Harvard University, and former Director, National Institute of Mental Health In sum, this is a first-rate work with a first-rate message." --The Journal of Nervous and Mental Disease "Many talk about the virtues of working across disciplines: this volume reveals how it can be accomplished."-Harvey V. Fineberg, President, the Institute of Medicine, the National Academies "Each of this welcome volume's case studies of successful interdisciplinary collaborations related to health is not only intrinsically interesting, but also illuminates how such research can be conducted."--Steven E. Hyman, Provost, Harvard University, and former Director, National Institute of Mental Health In sum, this is a first-rate work with a first-rate message." --The Journal of Nervous and Mental Disease Interesting, informative, and motivationsal. The variety of subjects and perspectives . . . enhance my own latent interest in several areas of supervision and field instruction. . . . Excellent! -Donald R. Bardill, PhD, Professor, School of Social Work, Florida State University, Tallahassee Fills a gap in the academic and practice literature. Its interdisciplinary nature is highly attractive. Prevents professional Myopia. Helps remind us that great practitioners can be terrible teachers. Every issue contains at least one useful idea. In today's publishing world that is a major accomplishment. --Harris Chaiklin, Professor, University of Maryland at Baltimore "Each of this welcome volume's case studies of successful interdisciplinary collaborations related to health is not only intrinsically interesting, but also illuminates how such research can be conducted."-- Steven E. Hyman, Provost, Harvard University, and former Director, National Institute of Mental Health "Many talk about the virtues of working across disciplines: this volume reveals how it can be accomplished."-Harvey V. Fineberg, President, the Institute of Medicine, the National Academies "The book is likely to be of value not only to scientists but also to decision makers in universities, institutions, and funding agencies. The authors not only summarize interesting and important bodies of work, but also highlight bumps and directions along the winding road they took to achieve such success in their respective interdisciplinary fields."--Journal of Clinical Psychiatry "For helpful work on interdisciplinary teaching and research specifically in the social sciences, I recommended [this book]."--Robert Axelrod, in his Presidential Address to the American Political Science AssociationTable of ContentsPART I: HOME IS WHERE THE HEART IS: THE SOCIAL WORLD AND CARDIOVASCULAR HEALTH AND DISEASE; PART II: MIND MATTERS: AFFECTIVE AND COGNITIVE NEUROSCIENCE; PART III: POSITIVE HEALTH: WHAT NOURISHES WHO FLOURISHES?; PART IV: IN SEARCH OF METHUSELAH: POPULATION PERSPECTIVES ON HEALTH AND LONGEVITY; PART V: A TALE OF TWO CITIES: PREVENTION AND MANAGEMENT OF HIV/AIDS

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Book SynopsisSo You Want to Be a Scientist offers readers a glimpse into the job of being a research scientist. It is not intended to be a step-by-step how to book. Rather, it is intended to fill a hole in the education of most would-be scientists, addressing explicitly many issues that are rarely addressed directly in training programs. Starting with thoughts about how to decide whether you''d want to pursue such a career (and if so, how to get started), the book works through some of the obvious topics relevant to a research profession (e.g. how to write a paper, give a talk, construct a grant proposal). It also examines less obvious, but equally important topics that are generally incorporated into a research education only by trial and error-e.g., thinking like a scientist, negotiating scientific politics, dealing with research ethics, and understanding social interactions. Chapters on the challenges and rewards of a career in research science include reflections on science as art and on the soTrade Review"There are too few good books about the positives and negatives of research careers in science, books aimed at young people who need to make choices in high school or college or even in graduate school. Philip A. Schwartzkroin, a neurosurgeon who specializes in epilepsy research, has written such a book. His book has something for everyone from high school through graduate school. His focus is a career in research, and nearly everything he says is equally applicable to careers in all the basic and applied sciences. It's a readable book, and I cannot imagine anyone interested in a career in science not finding it enormously useful."--Dan Agin, as reviewed in The Huffington Post "The author is a professor in the Department of Neurological Surgery at the University of California, Davis. Here, he offers 'an invaluable glimpse into the day-to-day life of the researcher' and gives advice on deciding 'whether you'd want to pursue such a career (and, if so, how to get started.'"--As featured in the "What's New in Sciences books section of Scibook.org and Science Book News "If you're a confused college student, still grasping for some direction in your life, you may have considered a career in research at some point. It's a little daunting to think about, being such a broad field, but Philip Schwartzkroin's helpful book, So You Want to Be a Scientist? makes it surprisingly navigable. Schwartzkroin has obviously experienced what students are going through; his clear and entertaining narrative outlines the whole process, from applying to grad school to working in a faculty position. He explains the challenges and opportunities students will encounter at every step of the journey, and provides advice and encouragement along the way."--As reviewed in The Observer, the student newspaper of Case Western University So You Want to Be a Scientist?...is intended as an introduction to the job of a research scientist. The intended audience is a student in college or high school who is contemplating such a career. However, even graduate students and post-doctoral fellows may also benefit from the perspective of a highly successful scientist who has trained and mentored many people...Dr. Schwartzkroin offers many insights and suggestions and discusses issues that, although obvious to most researchers, many young students may not have contemplated or even be aware of....While it is only a single person's viewpoint, the book is unbiased and general enough to be useful to almost anyone contemplating or starting a career as a research scientist. Readers will find this book useful for focusing their own thoughts and perceptions about research, and, hopefully, helping them to make some decisions regarding their personal path."--Saurabh R. Sinha, MD, PhD, as reviewed in Epilepsy & Behavior "...a crisp new book that should be on the reading list for all young scientists, Philip Schwartzkroin, a Professor of Neuroscience at the University of California Davis, rolls up his sleeves and quickly dispenses with this fairy tale notion of science in which the lone genius dreams up brilliant ideas that change the world. He lays bare the challenges that young scientists will face and the compromises that they may have to make...That the author can engage in these discussions without detracting from the big, beautiful ideas that draw people into science in the first place is a testament to his skill as a writer and mentor...We live in a time of enormous potential for scientific research, but which often feels plagued by a raging epidemic of angst about science as a career. Schwartzkroin's book, combined with a deeper appreciation of the extended value of a PhD, could be a much-needed antidote."--Reviewed by John E. Spiro in Nature NeuroscienceTable of ContentsIntroduction ; 1. Getting Started ; 2. Career Choices and Laboratory Nitty-Gritty ; 3. How to Think like a Scientist ; 4. How to Write a Scientific Paper ; 5. Giving Presentations and Talks ; 6. How to Compose/Submit Grant Applications ; 7. The Politics of Science ; 8. Ethical Conduct of Research ; 9. Scientific Research as a Creative Enterprise ; 10. The Role of the Scientist in Society ; 11. Personal Challenges ; 12. Rewards and Riches

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Book SynopsisThe Human Use of Animals presents case studies that look at the practical and ethical issues arising from the human use of animals. The case studies report the facts about some of the most compelling and difficult issues that confront society today in the human use of animals. Each case study combines the facts of the case with analysis of ethical issues.Table of ContentsPART I. INTRODUCTION; PART II. FARM ANIMALS; PART III. ANIMALS FOR ENTERTAINMENT; PART IV. COMPANION ANIMALS; PART V. RELIGIOUS USES OF ANIMALS; PART VI. ENDANGERED SPECIES; PART VII. BIOMEDICAL RESEARCH AND COSMETIC TESTING; PART VIII. BEHAVIORAL RESEARCH; PART IX. WILDLIFE RESEARCH; PART X. EDUCATIONAL USES OF ANIMALS

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Book SynopsisEvery year, hundreds of millions of animals are used in the service of biomedical research, despite the risk of extreme cruelty to these animal subjects. The expansion of the pharmaceutical industry and university research funding rapidly normalized its practice. What exactly are these experiments supposed to achieve from the scientific point of view and how effective are they? Working scientists answer these questions by saying that their research is absolutely necessary if we are to develop new therapies for human diseases. But is this really the case? Written by a scientist with over 40 years of laboratory experience, The Rise and Fall of Animal Experimentation critically examines this assumption and asks whether it is true that animal-based research achieves its aims and, if so, how often this occurs and if there are alternatives to performing animal-based science. The book takes readers through the history of animal experimentation: its early beginnings in antiquity, how it advancTable of ContentsPrologue: The Seminar Chapter 1: Greek Awakenings Chapter 2: Circular Arguments Chapter 3: Mapping Humanity Chapter 4: Fear and Trembling Chapter 5: The Modern Prometheus Chapter 6: I Want to be Your Dog Chapter 7: Not Just Kids Chapter 8: The Cloud Cap'd Towers Bibliography Index

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Book SynopsisGenetic Counseling Research: A Practical Guide is the first text devoted to research methodology in genetic counseling. This text offers step-by-step guidance for conducting research, from the development of a question to the publication of findings. Genetic counseling examples, user-friendly worksheets, and practical tips guide readers through the research and publication processes.With a highly accessible, pedagogical approach, this book will help promote quality research by genetic counselors and research supervisors--and in turn, increase the knowledge base for genetic counseling practice, other aspects of genetic counseling service delivery, and professional education. It will be an invaluable resource to the next generation of genetic counseling and its surrounding disciplines.Trade ReviewThe authors have done an excellent job with this manual of scientific methodology oriented to genetic counselors... The value of this book lies in the simplicity of its presentation and its usefulness to beginning genetic counselors who plan to embark on research and scientific writing. * Doody's Notes *Table of ContentsPreface ; Chapter 1: Developing Research Questions ; Chapter 2: Finding Sources ; Chapter 3: Writing a Review of Literature ; Chapter 4: Ethics in Research ; Chapter 5: Choosing a Paradigm ; Chapter 6: Designing a Quantitative Study ; Chapter 7: Quantitative Data Analysis: I've got data, how do I get answers? ; Chapter 8: Conducting Qualitative Genetic Counseling Research ; Chapter 9: Preparing a Manuscript for Publication ; Chapter 10: Guidelines for Directing Research ; References ; Appendix: Additional Resources for Researchers and Research Supervisors

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Book SynopsisDrugs like Lipitor, Plavix, Taxol, and Zoloft are integral in today''s medicinal world. These widely used products save lives and improve the quality of lives, playing a crucial role in everything from cholesterol management to cancer treatment. These advances in medicine were brought into existence after nuanced process of creation, featuring a wide range of chemical and pharmacological experimentation and discovery.Top Drugs: Their History, Pharmacology, and Synthesis provides an in-depth study on ten prominent drugs, outlining the chemistry behind each one''s creation. Jie Jack Li, a medicinal chemist and an expert on drug discovery, offers a thorough analysis of the landscape of current drug development. The comprehensive text is divided by health issues, including cardiovascular, cancer, metabolic diseases, and infectious diseases. Each section features individual chapters on significant drugs, outlining the chemistry and history of the drug''s discovery. Li begins each chapter wiTrade Review"This book will interest students and scientists in disciplines such as chemistry, biology, pharmacology, toxicology, clinical medicine, and biotechnology, as well as informed general audiences. Recommended." --CHOICETable of ContentsTable of Contents ; CARDIOVASCULAR DRUGS ; Chapter 1 Atorvastatin Calcium (Lipitor) ; Chapter 2 Clopidogrel (Plavix) ; Chapter 3 Amlodipine (Novasc) ; CANCER DRUGS ; Chapter 4 Paclitaxel (Taxol) ; Chapter 5 Imatinib (Gleevec) ; DRUGS FOR METABOLIC DISEASES ; Chapter 6 Sitagliptin (Januvia) ; CNS DRUGS ; Chapter 7 Sertraline (Cymbalta) ; Chapter 8 Olanzapine (Zyprexa) ; DRUGS TO TREAT INFECTIOUS DISEASES ; Chapter 9 Sofosbuvir (Sovaldi) ; ULCER DRUGS ; Chapter 10 Esomeprazole (Nexium)

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Book SynopsisMolecular understanding of cancer and cancer progression is at the forefront of many research programs today. High-throughput array technologies and other modern molecular techniques produce a wealth of molecular data about the structure, and function of cells, tissues, and organisms. Correctly analyzed and interpreted these data hold the promise of bringing new markers for prognostic and diagnostic use, for new treatment schemes, and of gaining new biological insight into the evolution of cancer and its molecular, pathological, and clinical consequences.Aimed at graduates and researchers, this book discusses novel advances in informatics and statistics in molecular cancer research. Through eight chapters from carefully chosen experts it brings the reader up to date with specific topics in cancer research, how the topics give rise to development of new informatics and statistics tools, and how the tools can be applied. The focus of the book is to give the reader an understanding of keyTable of ContentsPREFACE ; 1. Association Studies ; 2. Methods for DNA Copy Number Derivations ; 3. Methods for Derivation of LOH and Allelic Copy Numbers Using SNP Arrays ; 4. Bioinformatics of gene expression and copy number data integration ; 5. Analysis of DNA Methylation in Cancer ; 6. Pathway Analysis: Pathway Signatures and Classification ; 7. Two Methods for Comparing Genomic Data Across Independent Studies in Cancer Research: Meta-analysis and Oncomine Concepts Map ; 8. Bioinformatic Approaches to the Analysis of Alternative Splicing Variants in Cancer Biology ; INDEX

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Book SynopsisThe Oxford Textbook of Clinical Research Ethics is the first comprehensive and systematic reference on clinical research ethics. Under the editorship of experts from the U.S. National Institutes of Health of the United States, the book''s 73 chapters offer a wide-ranging and systematic examination of all aspects of research with human beings.Considering the historical triumphs of research as well as its tragedies, the textbook provides a framework for analyzing the ethical aspects of research studies with human beings. Through both conceptual analysis and systematic reviews of empirical data, the contributors examine issues ranging from scientific validity, fair subject selection, risk benefit ratio, independent review, and informed consent to focused consideration of international research ethics, conflicts of interests, and other aspects of responsible conduct of research.The editors of The Oxford Textbook of Clinical Research Ethics offer a work that critically assesses and advancesTrade Review"The Oxford Textbook of Clinical Research Ethics is the most comprehensive work on this broad topic to date. It sets a high bar for clinical research writing of any kind and, for that matter, textbooks of any kind...It presents thoughtful analyses of each topic by authorities in the field." --The Journal of Clinical Research Best Practices "Overall, the authors have achieved their goals--comprehensiveness, systematic analysis and wide ranging and international perspectives--providing a valuable resource for all those interested and involved in research. For occupational health professionals, it is a book that should be accessible on the library shelf." --Occupational MedicineTable of ContentsPart. 1: The History of Research with Humans; 1. Walter Reed and the Yellow Fever Experiments 2. The Nazi Medical Experiments 3. The Imperial Japanese Experiments in China 4. The Randomized Controlled Trial of Streptomycin 5. The Salk Polio Vaccine Field Trial of 1954 6. The Jewish Chronic Disease Hospital Case 7. The Hepatitis Experiments at the Willowbrook State School 8. The Tuskegee Syphilis Experiment 9. HIV Research 10. The Gelsinger Case 11. An Ethical Framework for Biomedical Research ; Part 2: Codes, Declarations, and Other Ethical Guidance for Research with Humans; 12. The Nuremberg Code 13. The Declaration of Helsinki 14. The Belmont Report 15. Regulations for the Protection 16. International Ethical Guidance from the Council for International Organizations of Medical Sciences 17. The Council of Europe 18. The European Community Directives on Data Protection and Clinical Trials 19. National Bioethics Commissions and Research ; Part 3: Context, Purpose, and Value of Clinical Research ; 20. Exploitation in Clinical Research 21. The Nature, Scope, and Justification of Clinical research: What is Research? Who is a Subject? 22. Four Paradigms of Clinical Research and Research Oversight 23. The Role of Patient Advocates and Public Representatives in Research ; Part 4: ; Scientific Design ; 24. Equipoise and Randomization 25. The Ethics of Placebo- Controlled Trials 26. Challenge Experiments 27. Emergency Research 28. Consent for Research with Biological Samples 29. Genetic Diagnostic, Pedigree, and Screening Research 30. Deception in Clinical Research 31. Ethics of Epidemiology: Observational Studies on Human Populations 32. Ethical Issues in Behavioral and Social Science Research 33. Phase 1 Oncology Research 34. Surgical Innovation and Research ; Part 5: Participant Selection ; 35. What is Fair in Participant Selection? 36. Incentives for Research Participants 37. Ethical Issues in Recruiting Research Participants 38. Ethical Issues in Research Involving Women 39. Ethical Issues in Research with Ethnic and Minority Populations 40. Research Involving Economically Disadvantaged Participants 41. Research Involving Those at Risk for Impaired Decision-making Capacity 42. Research with Children 43. Captive Populations: Prisoners, Students, and Soldiers 44. Research with Identifiable and Targeted Communities 45. Research with Health Volunteers 46. Research with Fetuses, Embryos, and Stem Cells ; Part 6: Risk-Benefit Assessments ; 47. Risk-Benefit Analysis and the Net Risks Test 48. Assessing the Comparing Potential Benefits and Risks of Harm 49. Risk-Benefit Assessment in Pediatric Research ; Part 7: Independent Review and Oversight ; 50. Institutional Review Boards: Their Origins and the Policies that Govern Them 51. Models of Institutional Review Board Function 52. Assessing and Comparing Potential Benefits and Risks of Harm 53. Data and Safety Monitoring Boards 54. The Food and drug Administration and Drug Development: Historic, Scientific, and Ethical Considerations ; Part 8: Informed Consent ; 55. A History of Informed Consent in Clinical Research 56. Philosophical Justifications of Informed Consent in Research 57. Legal and Regulatory Standards of Informed Consent in Research 58. The Therapeutic Misconception 59. Empirical Issues in Informed Consent for Research 60. The Assent Requirement in Pediatric Research ; Part 9: Respect for Human Research Participants ; 61. Confidentiality 62. Legal Responsibility to Research Subjects: Liability and Compensation for Injury 63. The Obligation to Ensure Standards ; Part 10 Multi-National Research ; 64. Appropriate Standards 65. Benefits to Host Countries 66. The Standard of Care in Multi-National Research 67. Responsiveness to Host Community Health Needs ; Part 11: Clinical Investigator Behavior ; 68. Conflicts of Interest in Medical Research: historical Developments 69. Conflicts of Interest 70. Empirical Data on Obligations of Publication: Authorship and Dissemination ; Index

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Book SynopsisHow the NIH Can Help You Get Funded takes a novel, non-formulaic approach in teaching readers how to write a grant -- and much more. The authors draw on their decades of experience working with both investigators and NIH personnel to anticipate their questions and concerns and help establish a comfortable, productive partnership between them. With this book''s focus on applying this knowledge to their personal grant strategy, readers will learn: how the NIH operates at the corporate level, as well as the culture and policies of individual institutes and centers how the NIH budget evolves over the course of a fiscal year and why the timing is important how to customize NIH Web site searches and use the data to increase chances of success how to identify appropriate program officers, study sections, and funding opportunitiesThe authors advise readers on developing each component of the grant application in order of the components'' influence on the final impact score. Individual funding mechanisms are reviewed along with grantsmanship tips specific to each. Readers learn the importance of reviewer-friendly formatting and organization of the text.The final chapters cover next steps after the application has been submitted-before, during, and after the review and funding decision. Strategies for resubmitting or repurposing applications are provided for those readers whose applications do not receive awards. The authors likewise anticipate the needs of readers who do receive funding but have questions on managing and maintaining their award.Amid ever-increasing competition for government research grants, How the NIH Can Help You Get Funded is an invaluable manual for how to pursue -- and sustain -- NIH funding.Trade ReviewThe two authors are experienced with and knowledgeable about this bureaucratic system and provide researchers an exceptional aid in working through the process...the authors do a magnificent job of explaining why the application process is so time-intense. The book also gives superb advice about developing a protocol and applying for a grant and what the different decision steps mean for researchers.100 - 5 stars! * Doody's Notes *Table of ContentsTable of Contents ; Foreword ; Preface ; Acknowledgments ; Essential Steps for Securing NIH Funding: A Quick Guide to Key Concepts ; Abbreviations ; Chapter 1: National Institutes of Health ; * Overview of agency organization and activities ; * Congressional authorization and appropriations ; * Office of the Director components and oversight ; * Overview of grant application and award process, including timeline over three fiscal years ; Chapter 2: Institutes and Centers ; * Overview of each institute and center, with a common data set for each (key links, contact information, details on how funding decisions are made) ; * Advisory Council role ; * Funding trend data where available (number of applications scored and funded at each percentile for FY12 and in some cases FY11) ; Chapter 3: Center for Scientific Review and the Peer Review Process ; * Overview of CSR and its activities ; * Application referral to an IC and study section ; * Picking the right reviewers ; * How your application is reviewed (in person and on the Internet) ; * Tips for crafting your application to help the reviewers ; * How your application is scored and what the score means ; * How percentiles are calculated and the difference between percentile, payline, and success rate ; * Becoming a reviewer ; Chapter 4: Office of Extramural Research ; * Overview of OER and its activities ; * Finding and understanding funding opportunities ; * Preparing the application package ; * Overview of eRA Commons ; * Overview of NIH grants policy ; Chapter 5: Federal Budget Process ; * Impact of federal budget status on NIH funding decisions ; * Process of proposing and passing the federal budget (and NIH appropriation) ; * How you can advocate for more NIH funding ; * What ICs do once they have their final appropriation ; Chapter 6: NIH Funding Data and Trends ; * Overview of available funding data ; * Change in success rate by R01 application type and submission (FY03, FY12) ; * Using NIH data to enhance your grant strategy ; Chapter 7: Getting at Mechanism ; * Overview of NIH funding mechanisms ; * Research grants (R) ; * Small business research project grant mechanisms ; * Research programs (P) ; * Career development (K) ; * Research training (F, T) ; * Supplements and bridge funding ; Chapter 8: Telling Your Story Well ; * Overview of developing your proposal, including where to put preliminary data ; * Correlation between individual criterion scores and impact score ; * Specific aims ; * Approach ; * Significance ; * Innovation ; * Introduction ; * Protection of research subjects ; * Project summary (abstract) ; * Investigators and environment ; * Cover letter ; * Budget ; Chapter 9: Presenting Your Message Well ; * Organizing your ideas in parallel with review process ; * Reader-friendly formatting tips ; * Science of communicating (rhetoric) ; * Videos in NIH applications ; Chapter 10: Getting by with a Little Help from Your Friends ; * Interacting with POs (tips and etiquette) ; * Importance of having others read your narrative ; Chapter 11: Before and After the Review ; * Interacting with the SRO before the review ; * What to expect the week your application is reviewed ; * When and how to interact with your PO after the review ; * Council actions after the review ; * Why appeals are rarely a good idea (and what to do when one is warranted) ; * Administrative review of the application and award processing ; Chapter 12: Is the Check in the Mail? ; * Understanding what your score and, if included, percentile mean ; * Timing of payline setting and funding decisions ; * Interacting with your PO ; Chapter 13: The Check is Not in the Mail ; * Next-steps if your application was not discussed or did not make the paylist ; * Strategies for resubmission ; * Timing of resubmission ; * Whether to change study sections ; * Repurposing your application ; * Long-term grant application strategy ; Chapter 14: The Check is in the Mail, BUT ; * Reduction in budget and/or number of years ; * If you relocate to another institution ; * Carrying funds over from one FY to the next and no-cost extensions ; * Compliance with NIH Public Access Policy required for non-competing renewal and citing NIH support in manuscripts ; Appendix A ; Index

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Book SynopsisIn the 1960s, University of Cincinnati radiologist Eugene Saenger infamously conducted human experiments on patients with advanced cancer to examine how total body radiation could treat the disease. Using the Saenger case as a means to reconsider cold war medical trials, this book examines the tensions at the heart of clinical studies of the time.Trade Review"What is truly original about Contested Medicine is that, by using the science studies approach applied to a specific historical case, Kutcher shows not only how ethics were constitutive of the shape of experimental work on cancer at its inception but how both of these things were mutually changed over time." - Christopher Lawrence, Wellcome Trust Centre for the History of Medicine, University College London"

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Book SynopsisTrade Review"You might think that museums are for collecting and laboratories for experimenting. Bruno J. Strasser tracks the creation of a hybrid culture--a 'way of knowing' that was comparative and experimental at the same time. Molecular biologists used the protein sequences of very various species to crack the genetic code. From bacteria to blood and protein to DNA, this engaging book restores collecting to the experimentalist tradition and gives 'big data' biology the history it needs."--Nick Hopwood, author of Haeckel's Embryos: Images, Evolution, and Fraud "Amidst all the hype surrounding Big Data and the life sciences, Bruno J. Strasser uncovers the deep continuities of collecting and comparing that link the latest data banks to venerable natural history museums. This bold book rethinks the relationship between field, laboratory, and archive, with important implications for the ethos of open publication in science."--Lorraine Daston, Max Planck Institute for the History of Science "The long-contested line between experimental life sciences and those that collect, compare, and classify is once more unsettled. It is now accepted that comparative sciences are open to experiment and always have been. And Bruno J. Strasser now argues that the celebrated achievements of experimental biology have similarly depended on practices of collecting and curating. And not just in our own new world of digital databases, but historically: from when experimenters first thought to make collecting forever obsolete. Strasser supports his bold revision with case studies of a broad range of sciences, from taxonomy to serology, experimental and then molecular biology, and bio-informatics. In its historical depth and breadth this is a benchmark book; and for all who want to know how life sciences really work, it's a must read."--Robert E. Kohler, University of Pennsylvania "A masterful, groundbreaking work: Strasser explores collecting activities in multiple branches of biology and medicine across several centuries, covering the territory from natural historical specimens to blood and proteins, and on to DNA sequences and contemporary big-data biology. His book assesses issues of lasting salience, including control of the collections, access to specimens and data, modes of publication, and assignment of authorship and credit. Strasser contends that big-data biology is not a sharp departure from the past but a hybrid, a joining of the experimentalist-reductionist inquiries into model organisms with the practices of collectors who classified and characterized their specimens and compared them with others. Strasser's research is wide and deep, his prose lucidly informative, and his analysis subtle, discerning, and persuasive." --Daniel J. Kevles, Yale University "Collecting Experiments is an exciting and welcome addition to the historiography of the long-standing debates about the changing roles of experimentation and description in the life sciences. Rejecting the older notion of an impassable dichotomy, Bruno J. Strasser suggests that the rise of experimental approaches to biology in the nineteenth century did not eclipse the more descriptive work of natural history, but rather became a part of an overall 'way of knowing' that included both approaches. 'Big data, ' whether obtained by experimental or observational methods had to be analyzed in the same manner. Strasser has done a great service to clarify the historical relationship between these two methodologies. It is a must for all scholars in the history of biology."--Garland Allen, Washington University in Saint Louis

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