Medical equipment, devices and techniques Books

Book SynopsisHighly commended in the Anaesthesia category of the 2014 BMA Medical Books awards! From reviews: "Altogether, this textbook offers an excellent detailed overview of basic principles, mechanics, and physics of technical equipment used in anaesthesia and intensive care medicine." Critical Care, Feb 2014 "This book is excellent. I have read a number of equipment related books and found most of them stale and filled with minutia. Instead this fresh look at equipment really makes it interesting to read and keeps your attention. With sections that give quick answers to how things work, advantages and disadvantages, in an easy to read format you get exactly what you want to know RIGHT away. In addition the full color photos and well done charts really add to the depth of this book. It is my opinion this may be one of the best books on the market for quick review of anesthesia and critical care equipment. Let's be honest, no one is sitting at home reading equipment books for pleasure so when you NEED the information you likely need it right away. This book does exactly that; easy format, clear and concise information with everything you need to know about a piece of equipment easy to find and within a page or two. I would recommend this to all trainees in anesthesia but also for those providers who like to be prepared in the operating room to deal with any issue that might arise." www.nurse-anesthesia.org, 8 Feb 2014 Equipment in Anaesthesia and Critical Care specifically follows the syllabus published by the Royal College of Anaesthetists and is the perfect guide for candidates studying for their FRCA qualifications. The book is beautifully illustrated and features high quality colour photographs throughout. The text is engaging and comprehensive, relating each piece of equipment back to its basic physics, mechanics and clinical context. The clear, concise and standardised format means that information is easy to access and perfect for revision. Every major piece of equipment is featured alongside colour photos, reproducible line diagrams, and information on its uses, how it works, pros and cons, and safety considerations. The authors, all senior registrars in anaesthesia and critical care, appreciate exactly what candidates need to know to pass the FRCA exam. They have identified and tackled difficult subjects which are often glossed over or omitted in other resources, to produce a book that is comprehensive, engaging and to the point. In addition to FRCA candidates, the book is also suitable for operating department practitioners, critical care staff, and physicians with an interest in anaesthesia or critical care.Trade ReviewFive-star reviews: OSCE/SOE life saver "Just passed my primary and this book saved my skin... Well laid out with colour photos supported by simple diagrams of inner workings/underlying concepts with easy to understand text covering the principles, key points and advantages/disadvantages. What is not to like? Having trawled my way through various books on this subject I have no doubt this bad boy will soon be the anaesthetic equipment book of choice for trainees." Amazon reviewer A must have for the exams "This is my first amazon review but I felt compelled to write this as I thought that this was such a good text. There are other equipment books out there (I own a few of them!) but none of the others bridge the gap between the technical aspects of the piece of equipment and the applied knowledge of it that is tested in the FRCA exams like this one. A perfect example is the ECG chapter, I had this question in my FRCA viva and everything that I needed to know about the topic was actually in this chapter. Infact the examiners questions almost worked through the headings as presented in the chapter in sequential order. I feel that this is a good book with the right level of detail for the exams. It also covers the obscure topics which are really hard to find elsewhere such as filters,pacemakers and decontamination. Ignore this book at your peril!" Amazon reviewer Essential! "This new book covers all the equipment and measurement for the primary FRCA, particularly invaluable for the OSCE. The content is comprehensive. Each section is laid out extremely clearly and concisely, with sections on pros, cons and safety issues for each bit of equipment. Although my senior colleagues recommended older books, I am glad I chose this one and I am sure it will become one of THE textbooks for primary FRCA. I have been recommending it to my peers." Amazon reviewer At last! "When I sat the primary FRCA there was, in all honesty, no really useful text for the equipment part of the syllabus. The current books at the time were disorganised in their layout and just didn't answer the kind of questions that come up especially in the viva/OSCE. This new equipment book has most definitely filled that gap. It's easy to navigate, readable, includes clear and reproducible diagrams and,crucially, affordable. The 'at a glance' style layout makes for efficient revision on your own and with friends, and I particularly like the pros/cons sections at the end of each. The fact that the authors are all senior registrars with recent exam perspective really shines through. My only tiny negative comment is that the paper quality is a little thinner than other textbooks which makes it less robust for those of us who walk around with a book in our bag at work / risk spilling tea on it etc - but if this is the biggest problem I can find then it's surely still worthy of 5 stars! Now revising for the final and looking forward to using this book to make some of those new equipment topics e.g. cardiopulmonary bypass that bit easier to learn. Also highly recommended for ODPs/trainee ODPs, non-anaesthetists doing a stint of critical care. I'll definitely be recommending this to other trainees in my department!" Amazon reviewer Refreshingly clear and well written "A refreshingly clear and well-written book! It looks great, with colour photos, diagrams and a crisp, uncluttered layout. I love the standardised format which makes dipping in and out of the book a breeze. The list of advantages and disadvantages for each bit of kit is a particularly nice touch that, in my opinion, gives the reader a better feel for the equipment in practise. I've only read a few chapters so far, but they seem to be set out in a logical manner with useful chapter introductions. My only gripe is that the authors have not (yet?) released a Kindle/ electronic version of the book. In summary, this was money well spent and I'm sure the book will become a firm favourite amongst trainees tackling the FRCA." Amazon reviewer Best equipment book for Primary FRCA "Structured on the exam syllabus, with very synthetic style and yet complete. Would recommend 100%" Amazon reviewer Great "Didn't do anaesthetics in the end but this was a fantastic book for trying to get to grips with all the bloody machines that go beep!" Amazon reviewer Five Stars "Good concise book, great for revision" Amazon reviewer Solid "A solid book that is perfect for MCQs, vivas and OSCEs. Nice looking, wide-ranging and easy to read- it 'does exactly what it says on the tin'. It now sits proudly on my shelf alongside similar FRCA big hitters like Cross & Plunkett, Peck Hill & Williams and A to Z. I wish this book had been available when I sat my primary last year." Amazon reviewer A 'must have' "Excellent book. Covers a wide range of equipment in more detail than other books of its kind. Great for anaesthetic trainees... a 'must have' I would say!" Amazon reviewer Easy to understand basic principles of physics "It has almost all equipments we use in our anaesthesia/ ICU practice. I would say if you want to understand anaesthesia/ICU equipments this is must read book. I would really appreciate good effort by author." Amazon reviewer Invaluable revision tool! "Very clearly written book with good layout and photos. Useful pros and cons sections and questions which helped consolidate the information. I found it an Invaluable revision source for FRCA exam." Amazon reviewer I don't intend to revise for more exams, but if I did, I'm sure this would help... "I passed my final FRCA a few years ago and happened to stumble across this book a few days ago. It's lay out is concise and well structured with most new topics/subtopics being organised on a new page. It has good photos and illustrations and I found the prose very easy to follow without becoming overwhelmed by dry information. It is sometimes difficult to predict what depth of knowledge you actually need to acquire about some of the more uncommon pieces of anaesthetic equipment (especially if you've never seen them in clinical practice before!) but I think this book gives an appropriate account of most things. Finally, it's a convenient size to carry in a ruck sack making it suitable for on-the-job revision when you actually encounter a new piece of kit. I don't intend to revise for any more exams but if I did I'm sure this book would be a useful addition to the library." Amazon reviewer Table of Contents1. Medical gases 2. Airway equipment 3. Breathing systems 4. Ventilators 5. Delivery of anaesthetic agents 6. Monitoring equipment 7. Filters and humidifiers 8. Regional anaesthesia 9. Critical care 10. Surgical equipment relevant to anaesthetists 11. Radiological equipment 12. Miscellaneous 13. Sample FRCA questions

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Book SynopsisTable of ContentsQuality Assessment and Safety Urine Specimen Types, Collection, and Preservation The Kidney Renal Function Physical Examination of Urine Chemical Examination of Urine Microscopic Examination of Urine Sediment Renal and Metabolic Disease Cerebrospinal Fluid Analysis Pleural, Pericardial, and Peritoneal Fluid Analysis Synovial Fluid Analysis Seminal Fluid Analysis Analysis of Vaginal Secretions Amniotic Fluid Analysis Fecal Analysis Automation of Urine and Body Fluid Analysis Body Fluid Analysis: Manual Hemacytometer Counts and Differential Slide Preparation Microscopy Appendix A: Reagent Strip Color Charts Appendix B: Comparison of Reagent Strip Principles, Sensitivity, and Specificity Appendix C: Reference Intervals Appendix D: Body Fluid Diluents and Pretreatment Solutions Appendix E: Manual and Historic Methods of Interest Answer Key Glossary Index

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Book SynopsisTable of ContentsPart I: INTRODUCTION TO SURGICAL TECHNOLOGY. 1. Introduction to Surgical Technology. 2. Legal Concepts, Risk Management, and Ethical Issues. 3. The Surgical Patient. 4. Physical Environment and Safety Standards. 5. Technological Science Concepts. Part II: PRINCIPLES AND PRACTICE OF SURGICAL TECHNOLOGY. 6. Principles of Microbiology. 7. Surgical Asepsis and Sterility: Best Practices and Techniques. 8. Emergency Situations and All-Hazards Preparation. 9. Surgical Pharmacology and Anesthesia. 10. Instrumentation, Equipment, and Supplies. 11. Hemostasis, Wound Healing, and Wound Closure. 12. Preoperative Surgical Case Management. 13. Intraoperative and Postoperative Surgical Case Management. Part III: SURGICAL PROCEDURES. 14. Diagnostic Procedures. 15. Minimally Invasive Applications. 16. General Surgery. 17. Obstetric and Gynecologic Surgery. 18. Ophthalmic Surgery. 19. Otorhinolaryngologic Surgery. 20. Oral and Maxillofacial Surgery. 21. Plastic and Reconstructive Surgery. 22. Genitourinary Surgery. 23. Orthopedic Surgery. 24. Cardiothoracic Surgery. 25. Peripheral Vascular Surgery. 26. Neurosurgery. Appendix A: Anatomy Plates. Index.

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Book SynopsisA step-by-step look at a growing and difficult to understand area Covers important aspects of ICD and CRT therapy with full-page illustrations, accompanying text and representative ICD tracings Offers free access to an accompanying website with unlimited access Useful for all health care workers involved with ICD patients.Trade Review"Overall, this is a good introductory book to ICD implantation and the relevant science behind its use." (Doody's Reviews, June 2009)Table of ContentsPreface. Acknowledgments. Introduction. Illustrations. 1. Cardiac tachyarrhythmias. 2. Indications. 3. ICD hardware Battery, capacitors and leads. 4. ICD implantation. 5. Sensing and detection. 6. SVT/VT discrimination. 7. ICD therapies. 8. ICD timing cycles. 9. Complications of ICD therapy. 10. Follow-up of ICDs. 11. Troubleshooting. 12. Special ICD functions and resynchronization therapy. 13. ICD function with emphasis on stored electrograms. Representative examples 1 to 65. Text. 1. Cardiac tachyarrhythmias. 2. Indications for ICD. 3. ICD hardware. 4. ICD implantation and lead systems. 5. Sensing and detection of ventricular tachycardia/fibrillation. 6. SVT/VT discrimination. 7. ICD therapies. 8. Timing cycles of ICDs. 9. Complications of ICD therapy. 10. ICD follow-up. 11. Troubleshooting. 12. Cardiac resynchronization. 13. Appendix A: American College of Cardiology/American Heart Association/European Society of Cardiology: 2006 Guidelines for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Death. 14. Appendix B: American College of Cardiology/American Heart Association/Heart Rhythm Society: 2008 Guidelines for ICD and CRT. Index.

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Book SynopsisAn Overview of TCI and TIVA was written by two of the leading lights in anaesthetic pharmacology. It is an invaluable source of information on the practice of total intravenous anaesthesia (TIVA) with or without target-controlled infusion (TCI) technology. In this long-awaited third edition of their popular book they have maintained the small size while thoroughly updating it to include recent developments and insights in the field, many of which have emerged from the work of their own research group. The fine balance between the provision of practical information to promote safe and effective clinical practice, with information on the scientific and theoretical foundations, will benefit and stimulate novice and more experienced TIVA users alike.

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Book SynopsisA visit to a physician these days is cold: physicians spend most of their time typing at computers, making minimal eye contact. Appointments generally last only a few minutes, with scarce time for the doctor to connect to a patient's story, or explain how and why different procedures and treatments might be undertaken. As a result, errors abound: indeed, misdiagnosis is the fourth-leading cause of death in the United States, trailing only heart disease, cancer, and stroke. This is because, despite having access to more resources than ever, doctors are vulnerable not just to the economic demand to see more patients, but to distraction, burnout, data overload, and their own intrinsic biases. Physicians are simply overmatched. As Eric Topol argues in Deep Medicine, artificial intelligence can help. Natural-language processing could automatically record notes from our doctor visits; virtual psychiatrists could better predict the risk of suicide or other mental health issues for vulnerable patients; deep-learning software will make every physician a master diagnostician; and we could even use smartphone apps to take our own medical "selfies" for skin exams and receive immediate analysis. . On top of that, the virtual smartphone assistants of today--Alexa, Siri, Cortana--could analyze our daily health data to reduce the need for doctor visits and trips to the emergency room, and support for people suffering from asthma, epilepsy, and heart disease. By integrating tools like these into their daily medical practice, doctors would be able to spend less time collecting and cataloging information, and more time providing thorough, intimate, and meaningful care for their patients, as no machine can.Artificial intelligence can also help remedy the debilitating cost of healthcare, both for individuals and the economy writ large. The medical sector now absorbs 20 percent of the US gross domestic product--it is largest sector by dollars and jobs. And it's very inefficient. Take the cost of medical scans: There are over 20 million medical scans performed in the US every day, and an MRI, for example, costs hundreds to thousands of dollars. AI could process 260 million medical scans (more than 2 weeks' worth) in less than 24 hours for a cost of only $1000. We pay billions and billions of dollars for the same work today.The American health care system needs a serious reboot, and artificial intelligence is just the thing to press the restart button. As innovative as it is hopeful, Deep Medicine ultimately shows us how we can leverage artificial intelligence for better care at lower costs with more empathy, for the benefit of patients and physicians alike.

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Book SynopsisThis open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.Table of ContentsData sources.- Data at scale.- Standards in healthcare data.- Using FAIR data / data stewardship.- Privacy / deidentification.- Preparing your data.- Creating a predictive model.- Diving deeper into models.- Validation and Evaluation of reported models.- Clinical decision support systems.- Mobile app development.- Operational excellence.- Value Based Healthcare (Regulatory concerns).

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Book SynopsisTable of Contents1. Introduction 2. Structure and bonding 3. Metallic biomaterials 4. Bioceramics 5. Polymeric biomaterials 6. Hard tissues and orhopedic soft tissues 7. Composite biomaterials 8. Tissue-biomaterials interactions 9. Orthopedic and dental biomedical devices 10. Soft tissue replacement and repair 11. Materials and devices for sensors and detectors: biocatalysts, bio imaging, and devices with integrated biological functionality 12. Biodegradable materials for medical applications

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Book SynopsisAbout our authors Diana Garza received her Bachelor of Science degree in Biology from Vanderbilt University in Nashville, Tennessee, and completed her Medical Laboratory Science certification requirements at Vanderbilt University Medical Center. Her interest in laboratory sciences and in teaching led her to a Master of Science in Education at the Peabody School of Vanderbilt University. She received her Doctor of Education in Allied Health Education and Administration through a collaborative graduate program of the Baylor College of Medicine at the University of Houston. Dr. Garza's laboratory and teaching experience continued at the University of Texas Health Science Center at Houston and, for many years, at the Microbiology Laboratory at the University of Texas M.D. Anderson Cancer Center, where she later became the Administrative Director of the Division of Laboratory Medicine. In 1990, Dr. Garza joined the faculty of Texas Woman's University - Houston CTable of ContentsPART 1: OVERVIEW, SAFETY PROCEDURES, AND MEDICAL COMMUNICATION1. Phlebotomy Practice and Quality Assessment2. Communication, Computer Essentials, and Documentation3. Professional Ethics, Legal, and Regulatory Issues4. Infection Control5. Safety and First AidPART 2: ANATOMY AND PHYSIOLOGY OF THE HUMAN BODY6. Medical Terminology, Anatomy, and Physiology of Organ Systems7. The Cardiovascular and Lymphatic SystemsPART 3: PHLEBOTOMY EQUIPMENT AND PROCEDURES8. Blood Collection Equipment for Venipuncture and Capillary Specimens9. Preexamination/Preanalytical Complications Causing Medical Errors in Blood Collection10. Venipuncture Procedures11. Capillary or Dermal Blood Specimens12. Specimen Handling, Transportation, and ProcessingPART 4: POINT-OF-CARE TESTING AND SPECIAL PROCEDURES13. Pediatric and Geriatric Procedures14. Point-of-Care Collections15. Blood Cultures, Arterial, Intravenous (IV), and Special Collection Procedures16. Urinalysis, Body Fluids, and Other Specimens17. Drug Use, Forensic Toxicology, Workplace Testing, Sports Medicine, and Related AreasAppendices:1. NAACLS Entry-Level Phlebotomist Competencies2. Competency Assessment Tracking Checklist3. Finding a Job4. International Organizations5. The Basics of Vital Signs Procedure A5-1 Taking Oral Temperature Procedure A5-2 Taking Aural Temperature Procedure A5-3 Taking Axillary Temperature Procedure A5-4 Assessing Peripheral Pulse Rate Procedure A5-5 Taking Blood Pressure Procedure A5-6 Assessing Respiration Rate6. Hand Hygiene in Health Care Settings: Stay Up-to-Date with the Centers for Disease Control and Prevention (CDC) and the Federal Drug Administration (FDA)7. Common Laboratory Assays, Reference Intervals, and Critical Limits8. Blood Collection and Allowable Volumes from Pediatric and Neonatal Patients9. Cautious Use of Abbreviations, Acronyms, and Symbols10. Formulas, Calculations, and Metric Conversion11. Military Time (24-Hour Clock)12. Basic Spanish for Specimen Collection Procedures13. Answers to Study Questions, Case Studies, and Competency Checklists

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Book SynopsisDescribes what a doctor can do if she/he cannot refer a patient, both in emergency and for 'cold surgery'. This work includes common problems such as Caesarean section, the resection of dead gut, and the release of pus from infected bones. It describes the organization and equipment found within an operating theatre.Trade ReviewIt is clear, thorough, well cross-referenced and deals with equipment and the organisation of the theatre, as well as with procedures themselves... almost certainly the best and most comprehensive text on surgery in developing countries. * Africa Health *Table of ContentsThe background to surgery; Theatres, antiseptics, and antibiotics; The control of bleeding; Basic methods and instruments; The surgery of sepsis: draining abscesses; Pus in the pleura, the pericardium, the peritoneum, and the pelvis; Pus in the muscles, bones and joints; Pus in the hands and feet; Methods for abdominal surgery; The acute abdomen: intestinal obstruction; The stomach; The appendix; The gall-bladder, pancreas, and spleen; Hernias; The surgery of conception; The surgery of pregnancy; The medicine of pregnancy; The surgery of labour; Other obstetric problems; Gynaecology; The breast and the thyroid; Proctology; Urology; The eye; The ear, nose, and throat; The teeth and mouth; Orthopaedics; Paediatric surgery; Surgery, AIDS, and hepatitis B; The surgery of tubercolosis; The surgery of leprosy; The surgery of `tropical' diseases; Oncology; Terminal care; Miscellaneous; Appendices.

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Book SynopsisThis book defines the state of scientific research focused on the development, experimental evaluation, and effective implementation of technology-based therapeutic tools targeting behavioral health. Written by an expert interdisciplinary group of authors, Behavioral Health Care and Technology defines the opportunity for science-based technology to transform models of behavioral health care.Trade ReviewKudos to Marsch, Lord, and Dallery for a thoughtful interdisciplinary collection that bridges the disconnect between theoretical and practical aspects of technology use to improve behaviors related to critical health issues in the US and globally. * Patricia Mechael, Columbia University *For those who purchase this book, I would not recommend letting it gather dust on the bookshelf. In a similar vein, I hope that the editors have already begun work on the second edition, because like our cellular devices, this book will be history before we know it. * H. Russell Searight, PsycCRITIQUES *This book would be of interest to both researchers and clinicians from a wide variety of disciplines with a shared interest in behavioural healthcare and technology... a useful handbook for introducing this exceptionally interesting topic area. * Sara Simblett, Journal of Mental Health *Table of ContentsContents ; Introduction ; Section I: OPTIMAL MODELS FOR DEVELOPING TECHNOLOGY-BASED THERAPEUTIC TOOLS TARGETING BEHAVIORAL HEALTH ; Chapter 1: Technology and the Stage Model of Behavioral Intervention Development ; Chapter 2: Theoretical Models to Inform Technology-Based Health Behavior Interventions ; Section II: EVIDENCE-BASED APPROACHES TO HARNESSING TECHNOLOGY TO PROMOTE BEHAVIORAL HEALTH ; Chapter 3: Behavioral Monitoring and Assessment Via Mobile Sensing Technologies ; Chapter 4: Technology-based Behavioral Interventions for Alcohol and Drug Use Problems ; Chapter 5: Using Behavioral Intervention Technologies to Reduce the Burden of Mood and Anxiety Disorders ; Chapter 6: Technologies for People with Serious Mental Illness ; Chapter 7: Applying Technology to Medication Management and Adherence ; Chapter 8: Technological Approaches to Assess and Treat Cigarette Smoking ; Chapter 9: Technology-based Interventions to Promote Diet, Exercise and Weight Control ; Chapter 10: Evidence-based Approaches to Harnessing Technology to Provide Social-Emotional Support ; Section III: METHODS FOR THE EVALUATION OF TECHNOLOGY-BASED BEHAVIORAL HEALTHCARE ; Chapter 11: mHealth Analytics ; Chapter 12: Research Designs to Develop and Evaluate Technology-Based Health Behavior Interventions ; Chapter 13: Evaluating Mechanisms of Behavior Change to Inform and Evaluate Technology-Based Interventions ; Chapter 14: Economics Analysis of Technology-Based Behavioral Healthcare Systems ; Section IV: EFFECTIVE DISSEMINATION AND IMPLEMENTATION ; Chapter 15: Models for Effective Dissemination and Implementation of Technology-based Behavioral Health Care Systems ; Chapter 16: Privacy, Security, and Regulatory Considerations as Related to Behavioral Health Information Technology ; Chapter 17: Harnessing mHealth in Low-Resource Settings to Overcome Health System Constraints and Achieve Universal Access to Health ; Chapter 18: Open Architecture and Standards in Mobile Health ; Section V: PUBLIC HEALTH AND POLICY IMPLICATIONS ; Chapter 19: Using Technology to Integrate Behavioral Health into Primary Care ; Chapter 20: The Potential of Technology Solutions for Behavioral Healthcare Disparities ; Chapter 21: Behavioral Health Information Technology Adoption in the Context of a Changing Healthcare Landscape ; Chapter 22: Envisioning the Future: Transformation of Health Care Systems via Technology

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Book SynopsisFully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers theTrade ReviewThe simple organization, the pertinent historical cues a practitioner should be looking for, the completeness of the descriptions of the physical findings, supported by the excellent graphics, makes this one of the best books on physical examination available. I highly recommend it to medical educators and medical students, residents and attendings. There is much to be learned by those at all levels of training from this well-organized, well-written book... 5 stars! * Doody's Notes *I really like it! I'll definately be referring to this one and recommending to my students. Excellent! * British Medical Association Book Awards Finalist *Table of Contents1. Communication skills ; 2. The history ; 3. General and endocrine examination ; 4. Skin, hair and nails ; 5. The cardiovascular system ; 6. The respiratory system ; 7. The abdomen ; 8. The nervous system ; 9. The eyes ; 10. The locomotor system ; 11. The ear, nose and throat ; 12. The male reproductive system ; 13. The female reproductive system ; 14. The obstetric assessment ; 15. The breast ; 16. The psychiatric assessment ; 17. The paediatric assessment ; 18. Practical procedures ; 19. Clinical data interpretation ; 20. Other investigations

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Book SynopsisUsing bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms.Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides

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Book SynopsisThe first comprehensive guide to the integration of Design for Six Sigma principles in the medical devices development cycle Medical Device Design for Six Sigma: A Road Map for Safety and Effectiveness presents the complete body of knowledge for Design for Six Sigma (DFSS), as outlined by American Society for Quality, and details how to integrate appropriate design methodologies up front in the design process. DFSS helps companies shorten lead times, cut development and manufacturing costs, lower total life-cycle cost, and improve the quality of the medical devices. Comprehensive and complete with real-world examples, this guide: Integrates concept and design methods such as Pugh Controlled Convergence approach, QFD methodology, parameter optimization techniques like Design of Experiment (DOE), Taguchi Robust Design method, Failure Mode and Effects Analysis (FMEA), Design for X, Multi-Level Hierarchical Design methodology, and Response Surface methodoTrade Review"The book is well-written and the authors use well versed descriptions, easy to read figures and tables, and industry-related examples and case studies to explain what can be very complex concepts and processes. This book would be a valuable resource for anyone in the field of medical device design." (Doody's Book Reviews, October 2008)Table of ContentsForeword. Preface. 1 Medical Device Design Quality. 1.1 Introduction. 1.2 The Essence of Quality. 1.3 Quality Operating System and the Device Life Cycle. 1.4 Evolution of Quality. 1.5 Business Excellence: A Value Proposition. 1.6 Summary. 2 Design for Six Sigma and Medical Device Regulation. 2.1 Introduction. 2.2 Global Perspective on Medical Device Regulations. 2.3 Medical Device Classifi cation. 2.4 Medical Device Safety. 2.5 Medical Device Quality Management Systems Requirements. 2.6 Medical Device Regulation Throughout the Product Development Life Cycle. 2.7 Summary. 3 Basic Statistics. 3.1 Introduction. 3.2 Common Probability Distributions. 3.3 Methods of Input and Output Analysis. 3.4 Descriptive Statistics. 3.5 Inferential Statistics. 3.6 Normal Distribution and Normality Assumption. 3.7 Summary. 4 The Six Sigma Process. 4.1 Introduction. 4.2 Six Sigma Fundamentals. 4.3 Process Modeling. 4.4 Business Process Management. 4.5 Measurement Systems Analysis. 4.6 Process Capability and Six Sigma Process Performance. 4.7 Overview of Six Sigma Improvement. 4.8 Six Sigma Gose Upstream: Design for Six Sigma. 4.9 Summary. Appendix 4A: Cause-and-Effect Tools. 5 Medical Device Design for Six Sigma. 5.1 Introduction. 5.2 Value of Designing for Six Sigma. 5.3 Medical Device DFSS Fundamentals. 5.4 The ICOV Process in Design. 5.5 The ICOV Process in Product Development. 5.6 Summary. 6 Medical Device DFSS Deployment. 6.1 Introduction. 6.2 Medical Device DFSS Deployment Fundamentals. 6.3 Predeployment Phase. 6.4 Deployment Phase. 6.5 Postdeployment Phase. 6.6 DFSS Sustainability Factors. 6.7 Black Belts and the DFSS Team: Cultural Change. 6.8 Summary. 7 Medical Device DFSS Project Road Map. 7.1 Introduction. 7.2 Medical Device DFSS Team. 7.3 Medical Device DFSS Road Map. 7.4 Software DFSS ICOV Process. 7.5 Summary. 8 Quality Function Deployment. 8.1 Introduction. 8.2 History of QFD. 8.3 QFD Fundamentals. 8.4 QFD Methodology. 8.5 HQQ Evaluation. 8.6 HQQ 1: The Customer’s House. 8.7 HQQ 2: Translation House. 8.8 HQQ 3: Design House. 8.9 HQQ 4: Process House. 8.10 Application: Auto 3D. 8.11 Summary. 9 DFSS Axiomatic Design Method. 9.1 Introduction. 9.2 Axiomatic Method Fundamentals. 9.3 Introduction to Axiom 1. 9.4 Introduction to Axiom 2. 9.5 Axiomatic Design Theorems and Corollaries. 9.6 Application: Medication Mixing Machine. 9.7 Application: Axiomatic Design Applied to Design Controls. 9.8 Summary. Appendix 9A: Matrix Review. 10 DFSS Innovation for Medical Devices. 10.1 Introduction. 10.2 History of the Theory of Inventive Problem Solving. 10.3 TRIZ Fundamentals. 10.4 TRIZ Problem-Solving Process. 10.5 Ideal Final Result. 10.6 Building Suffi cient Functions. 10.7 Eliminating Harmful Functions. 10.8 Inventive Principles. 10.9 Detection and Measurement Concepts. 10.10 TRIZ Root Cause Analysis. 10.11 Evolution trends in Technological Systems. 10.12 TRIZ Functional Analysis and Analogy. 10.13 Application: Using Triads to Predict and Conceive Next-Generation Products. 10.14 Summary. Appendix 10A: Contradiction Matrix. 11 DFSS Risk Management Process. 11.1 Introduction. 11.2 Planning for Risk Management Activities in Design and Development. 11.3 Risk Assessment Techniques. 11.4 Risk Evaluation. 11.5 Risk Control. 11.6 Postproduction Control. 11.7 Summary. Appendix 11A: Robust Design Failure Mode and Effects Analysis. 11A.1 Parameter Diagram. 11A.2 Robust Design FMEA Elements. 12 Medical Device Design for X. 12.1 Introduction. 12.2 Design for Reliability. 12.3 Design for Packaging. 12.4 Design for Manufacture and Design for Assembly. 12.5 Design for Maintainability. 12.6 Design for Serviceability. 12.7 Summary. 13 DFSS Transfer Function and Scorecards. 13.1 Introduction. 13.2 Design Mapping. 13.3 Design Scorecards and the Transfer Function. 13.4 Transfer Function Mathematics. 13.5 Transfer Function and Optimization. 13.6 Monte Carlo Simulation. 13.7 Summary. 14 Fundamentals of Experimental Design. 14.1 Introduction. 14.2 Classical Design of Experiments. 14.3 Factorial Experiment. 14.4 Analysis of Variance. 14.5 2k Full Factorial Designs. 14.6 Fractional Factorial Designs. 14.7 Other Factorial Designs. 14.8 Summary. Appendix 14A. 14A.1 Diagnostic Plots of Residuals. 14A.2 Pareto Chart of Effects. 14A.3 Square and Cube Plots. 14A.4 Interaction Plots. 15 Robust Parameter Design for Medical Devices. 15.1 Introduction. 15.2 Robust Design Fundamentals. 15.3 Robust Design Concepts. 15.4 Application: Dynamic Formulation. 15.5 Summary. 16 Medical Device Tolerance Design. 16.1 Introduction. 16.2 Tolerance Design and DFSS. 16.3 Worst-Case Tolerance. 16.4 Statistical Tolerances. 16.5 Taguchi’s Loss Function and Safety Tolerance Design. 16.6 High- vs. Low-Level Requirements’ Tolerance Relationships. 16.7 Taguchi’s Tolerance Design Experiment. 16.8 Summary. 17 Medical Device DFSS Verifi cation and Validation. 17.1 Introduction. 17.2 Design Verifi cation Process. 17.3 Production Process Validation. 17.4 Software Validation. 17.5 Design Validation. 17.6 Summary. 18 DFSS Design Transfer. 18.1 Introduction. 18.2 Design Transfer Planning. 18.3 Process Control Plan. 18.4 Statistical Process Control. 18.5 Process Capability. 18.6 Advanced Product Quality Planning. 18.7 Device Master Record. 18.8 Summary. 19 Design Change Control, Design Review, and Design History File. 19.1 Introduction. 19.2 Design Change Control Process. 19.3 Design Review. 19.4 Design History File. 19.5 Summary. 20 Medical Device DFSS Case Study. 20.1 Introduction. 20.2 DFSS Identify Phase. 20.3 DFSS Characterize Phase. 20.4 DFSS Optimize Phase. 20.5 DFSS Verify/Validate Phase. 20.6 Summary. Glossary: DFSS Terminology. Appendix: Statistical Tables. References. Index.

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Book SynopsisDesign, Execution, and Management of Medical Device Clinical Trials provides practical examples, ranging from the development of clinical protocol and the selection of clinical sites and ending with the completion of the final clinical report study.Table of ContentsList of Abbreviations xi Preface xv Acknowledgments xxi 1 An Overview of Clinical Study Tasks and Activities 1 Key Clinical Study Tasks and Activities 2 Discussion of Key Tasks and Activities 3 Management of Key Clinical Tasks and Activities 9 Example of the Spread Sheet for Managing Clinical Study Activities 10 The Clinical Research Team 10 2 Development of Clinical Protocols, Case Report Forms, Clinical Standard Operating Procedures, Informed Consent Form, Study Regulatory Binder, Study Research Agreement, and Other Clinical Materials 15 Clinical Protocol 17 Case Report Forms (CRFs) 28 Example of the Case Report Form Template 32 Informed Consent Form (ICF) 35 Instructions for Use of Device 38 Study Regulatory Binder 39 Study Research Agreement 40 Research Agreement Template 43 Research Contract Challenges 50 Clinical Forms and Certificates 51 Clinical Standard Operating Procedures (SOPs) 54 3 Qualification/Selection of Study Investigators and Study Monitoring Visits 63 Qualification and Selection of Investigators 64 Monitoring Visits 67 Monitoring Reports 73 Interim Monitoring Visit Report Template 75 4 Adverse Events Definitions and Reporting Procedures 81 Adverse Event Definitions 83 Policies, Regulations, and Guidelines Regarding Adverse Event Reporting 84 Adverse Event Reporting Pathway 84 Terms for Causality Assessment 85 GAPS/Challenges in Adverse Event Reporting 86 Adverse Event Reporting Time Periods (21 CFR 803) 88 Differences between the United States and Europe in Reporting Adverse Events 88 Serious Adverse Event Narratives 89 Classification of Adverse Events 90 Special Requirement for Reporting Certain Adverse Events 92 Case Example 92 Mandatory Device Reporting for FDA-Approved Devices 92 5 Statistical Analysis Plan (SAP) and Biostatistics in Clinical Research 93 Statistical Analysis Plan (SAP) 94 Selection of Study Endpoints 97 Biostatistics in Clinical Research 101 6 Final Clinical Study Report 113 Final Clinical Report’s Outline 114 Discussion of Sections in the Final Clinical Report 116 7 Medical Device Regulations Combination Product, Study Committees, and FDA-Sponsor Meetings 127 Medical Device Regulations 129 Combination Products 164 Study Committees 168 FDA-Sponsor Meetings 170 Registration of Clinical Trials 174 Implementation of the HIPAA Privacy Rule in Clinical Research 175 Institutional Review Boards (IRB) 180 FDA’s Oversight of Clinical Trials (Bioresearch Monitoring) 191 Code of Federal Regulations of Medical Devices 194 8 Design Issues in Medical Devices Studies 195 Design of the Clinical Trial 196 Assumptions and Parameters of Clinical Trial Design 196 Clinical Trials’ Design Issues and Data Analysis Issues 202 Use of Historic Controls as the Control Group in IDE Studies 206 Summary of Recommendations When Using Historic Controls 218 9 Investigator-Initiated Clinical Research 221 Definition and Examples of Investigator-Initiated Clinical Research 222 Development, Conduct, and Management of Investigator-Initiated Clinical Research 224 Regulation of Investigator-Initiated Clinical Research 225 Required Infrastructure for Investigator-Initiated Clinical Research 226 Clinical Research Sponsored by NIH 227 10 Ethical Conduct for Human Research 229 The Nuremberg Code (1947) 230 World Medical Association—Declaration of Helsinki (1964–Present) 231 National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1974) 231 The Belmont Report (1978) 232 Special Ethical Concerns in Clinical Research on Use of Placebo 232 Glossary of Clinical Trial and Statistical Terms 235 References 249 Index 255

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Book SynopsisClinical trials tasks and activities are widely diverse and require certain skill sets to both plan and execute. This book provides professionals in the field of clinical research with valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It discusses key obstacles such as challenges to patient recruitment, investigator and study site selection, and dealing with compliance issues. Through practical examples, professionals working with medical device clinical trials will discover the appropriate steps to take.Table of ContentsList of Abbreviations xi Preface xiii Acknowledgments xvii 1. Challenges to the Design of Clinical Study 1 Development of Clinical SOPs 3 Selection of Study Patients, Investigators, and Study Sites 3 Definition of Enrolled Subjects in a Clinical Study 7 Definition of the Investigational Device System 7 Research Contract Challenges 7 Review of Literature 9 Challenges to the Design of the Study Protocol, Statistical Analysis Plan (SAP), and Selection of Study Endpoints 11 Masking or Blinding 12 Primary and Secondary Outcomes 14 Selection of Study Endpoints 14 Differences between the Primary Endpoint in FDA and CE Mark Studies 15 SAP and Study Endpoints 15 Components of the SAP for Clinical Trials 17 Roles and Responsibilities of the Clinical Personnel in Completing the Study Protocol 19 Changing the Primary Outcome during the Conduct of the Study 20 Definition of Primary and Secondary Endpoints 22 Combined “Composite” Endpoints 22 Surrogate Endpoints 23 Reducing the Study’s Sample Size 25 Statistical Terms to Define Endpoint Measurements 25 Reporting Results of Clinical Trials 28 Superiority and Equivalence Trials 30 Subgroup Analysis 33 Challenges to ICF 35 Risk/Benefit Analysis 41 2. Challenges to Managing the Study 43 Enhancing Patient Enrollment by Relaxation of Study Criteria 45 Compliance with the Study Protocol 46 Challenges Associated with Data Accuracy and Completeness 47 Data Analysis 49 Data Integrity 55 Criteria for Using Meta-Analysis Studies 56 Who Should have Access to Clinical Trial Records 57 Managing Study Data and Quality Assurance 58 Missing Data Analysis 59 Examination of Data across Study Sites 60 Challenges to Adverse Event Reporting 62 Adverse Event Coding Systems 66 Protocol Deviation Report 68 Adverse Event Reporting in Final Study Clinical Report 68 Difference between the US and EU Definitions and Reporting of Adverse Events 69 Adverse Event Reporting Challenges 69 Minimization of Bias in Clinical Trials 69 3. Selection of Historic Controls 71 Types of Control Group in Medical Device Clinical Trials 73 Purpose of Control Group 73 Use of Placebo Control 74 Advantages of Randomized Control Clinical Trials 74 Disadvantages of Randomized Control Clinical Trials 74 Commonly Used Pivotal Designs 75 Definition of Historic Control 77 Objective Performance Criteria (OPC) 78 Examples of Clinical Studies with Historic Controls 80 LACI Clinical Study 80 Left Ventricular Assist Devices 86 Summary of Clinical Studies 88 Summary of Recommendations for Historic Control 96 4. Fraud and Misconduct in Clinical Trials 99 Fraud and Misconduct in Clinical Trials 100 Warning Signs of Fraud 101 Tips for Detecting Serious Misconduct 102 False Claims Act 102 Fraud Prevention 103 Policy on Handling Complaints of Misconduct 103 Reporting Research Misconduct 104 Bioresearch Monitoring Information System (BMIS) 104 5. Challenges to the Regulation of Medical Device 107 Determination of 510(K) Devices 108 510(K) “Substantial Equivalence Decision Making Process” 111 Determination of Nonsignificant Risk Devices (NSR) 111 Similarities and Differences between Medical Device and Drug Regulations in Clinical Trials 112 Definitions of Drugs and Devices 113 Combination Products 126 FDA–Sponsor Meetings 129 BIMO Inspection 130 Investigator-Initiated Clinical Trials 132 6. Challenges of Global Clinical Studies and the CE Mark Process 137 Global Trial Considerations 138 Global Harmonization Task Force Challenges 142 FDA Recommendations on Acceptance of Foreign Clinical Sites 143 Operational Tips on Conductance of Global Clinical Trials 143 CE Mark Process and Challenges 146 International Standard ISO 14155 148 Differences between FDA and CE Mark Clinical Trials 157 Challenges to CE Mark Studies 160 7. Challenging FDA PMA Cases 163 PMA P970029 (TMR 2000 Holmium Laser System) 164 PMA P040012 Carotid Stenting for Treating Carotid Disease 175 Historic Control Assumptions 175 Use of Angiographic Late Loss as Primary Endpoint in Drug-Eluting Stent PMA P070015 (Xience V DES) 186 8. Bioethics in Clinical Research 199 Bioethical Challenges in Clinical Studies 200 Good Clinical Practice for the Investigator 201 WHO Principles of GCP 202 Guidelines and Ethical Principles 204 IRB Review Process 206 Glossary of Clinical, CE Mark, and Statistical Terms 211 References 217 Index 221

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Book SynopsisAn examination of the various tests currently available for the assessment of infant respiratory function, which describes the performance, interpretation and possible refinement of each procedure. The text also reviews essential measurement conditions and equipment requirements.Table of ContentsPartial table of contents: Symbols, Abbreviations, and Units in Infant Pulmonary FunctionTesting (P. Quanjer, et al.). Measurement Conditions (C. Gaultier, et al.). Equipment Requirements for Infant Respiratory Testing (P. Sly &G. Davis). Measurement of Flow and Volume (J. Bates, et al.). Measurements During Tidal Breathing (S. Stick). Respiratory Inductive Plethysmography (J. Adams). Esophageal Manometry (Al. Coates, et al.). Passive Respiratory Mechanics (M. Fletcher, et al.). Measurements of Chest Wall Function (J. Allen & Y.Sivan). Forced Oscillation Technique (K. Desager, et al.). Forced Expiratory Maneuvers (P. Le Souef, et al.). Noninvasive Determination of Blood Gases (C. Poets & R.Martin). Clinical Epidemiology and Future Directions (J. Hanrahan, etal.). Index.

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Book SynopsisIntroduces the fundamental biological processes that influence these sophisticated, procedures. This text provides details about molecular-level events that happen at the tissue-implant interface and explores material, biological, and physiological consequences of these events. It emphasizes the importance of the body's wound-healing response.Trade Review"...well illustrated with a glossary, end-chapter summaries, and references...materials, scientists, medical device designers and manufacturers, corrosion researchers and practitioners, surgeons, and clinicians will profit from reading this book." (CORROSION, February 2006) "…a concise, topical, and not overly technical hardbound…the strengths of this book are its crisp information and condensed summaries. The jewels of this book are the diagrams and tables." (Annals of Biomedical Engineering, Issue 31:11) "...delivers precisely what the authors intended...excellent book...great introduction...nicely complements existing texts..." (Advanced Materials, Vol 16(4), 17 Feb 2004) "This text would be of great use for faculty teaching courses on tissue-biomaterial interactions." (IEEE Engineering in Medicine and Biology, May/ June 2003) "...a pleasure to read...highly recommendable..." (Biomateria.com) "...excellent attention to detail…recommended for graduate students, faculty and researchers, and bioengineers and physicians." (Choice, Vol. 40, No. 6, February 2003)Table of ContentsPreface. Acknowledgments. Introduction. Biomaterials. Proteins. Protein-Surface Interactions. Blood-Biomaterial Interactions and Coagulation. Inflammation and Infection. The Immune System and Inflammation. Wound Healing. Biomaterial Surface and the Physiological Environment. Biocompatibility. Example 1: Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia. Example 2: Replacing Joints and Teeth. Answers to Quiz Questions. Gloassry. Index.

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Book SynopsisThe new edition of this widely-used sourcebook details the startlingly array of diagnostic equipment available in the medical laboratory of the nineties, and also covers maintenance and quality assurance for each type of instrument. This book includes 17 completely rewritten chapters and 7 new ones, on nephelometry and turbidimetry, gas chromatography, mass spectrometry, flow cytometry, automated immunoassay systems, automated blood bank systems, and physician''s office laboratory instrumentation.Table of ContentsPartial table of contents: Principles of Electricity and Electronics (R. Earl). Analytical Balances (J. Thompson & M. Haven). Refractometry (R. Juel & M. Steinrauf). Flame Emission and Atomic Absorption Spectroscopy (M. Haven & M. Lohff). Fluorometry and Fluorescence Polarization (P. Studts, et al.). Electrochemical Methods of Analysis (E. Goshorn, et al.). Basic Principles of Chromatography (U. Otten). Gas Chromatography (D. Hage). Flow Cytomtery (M. Collins & S. Pirruccello). Automated Immunoassay Systems (L. Arnold & M. Fiore). Automated Coagulation Systems (J. Olson & B. Pennell). Automated Blood Banking Systems (J. Landmark). Answers to Questions and Problems. Index.

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Book SynopsisThis definitive source provides practicing professionals and students in the occupational, environmental, and public health and safety fields with the functional basics of biological monitoring. The author examines how environmental exposures to particular chemicals are related to concentrations of markers in body tissues and fluids. Biological Monitoring integrates the applied sciences of industrial/environmental hygiene, epidemiology, public health, occupational medicine, toxicology, biochemistry, and analytical chemistry with the basic sciences to interpret the connections between exposures and lifestyle/environmental influences, and their effects on humans. This comprehensive introduction provides dependable, detailed coverage of: * monitoring for harmful substances in the workplace * the benefits and limitations of testing for critical levels of toxic materials in bodily tissues and fluids * state-of-the-art developments in biological monitoring * a wide vaTable of ContentsPartial table of contents: BASIC MECHANISMS. Concepts in Chemistry. Concepts in Biochemistry. ROUTES OF EXPOSURE, DISTRIBUTION, METABOLISM, AND BIOLOGICAL MONITORING MEDIA. Exposure Routes. Distribution of Xenobiotics After Absorption. MEDICAL/HEALTH SURVEILLANCE, MEDICAL SCREENING, AND MEDICAL MONITORING. Medical Surveillance. Medical Markers and Factors that Affect Them. ADDUCTS; IMMUNOLOGY; AIDS. Adducts: An Overview. DNA Adducts. Hemoglobin Binding as a Dose Monitor for Human Exposure to Carcinogens and Mutagens. Basic Immunology. AIDS Therapy: Functional Changes in Immune Regulating Proteins Caused by Preparation Techniques. Volatile Nitrites: A Valid Health Concern. SPECIAL TOPICS. Biological Exposure Indices. Biological Monitoring and Pesticides. Appendices. Index.

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Book SynopsisA comprehensive survey of technological developments in Virtual Reality for use in a variety of medical procedures Medicine and the biological sciences have long relied on visualizations to illustrate the relationship between anatomic structure and biologic function. The new multidimensional imaging modalities are powerful counterparts to traditional forms of observation-surgery, postmortem examination, or extensive mental reconstruction. VR technologies have reached unimagined levels of sophistication and utility, giving physicians and students new avenues for planning and practicing surgery and diagnostics. The two volumes of Information Technologies in Medicine thoroughly explore the use of VR technology in three-dimensional visualization techniques, realistic surgical training prior to patient contact, and actual procedures in rehabilitation and treatment, including telemedicine and telesurgery. Editors Akay and Marsh have brought together all the availablTable of ContentsPREFACE. PART I: TREATMENT. 1. Neuro/Orthopedic Rehabilitation and Disability Solutions Using Virtual Reality Technology (Walter J. Greenleaf). 2. The Use of Virtual Reality Technology in the Treatment of Anxiety Disorders (Brenda K. Wiederhold and Mark D. Wiederhold). 3. Virtual Reality for Health Care (L. Beolchi and G. Riva). 4. Robot-Assisted Microsurgery Development at JPL (Hari Das, Tim Ohm, Curtis Boswell, Rob Steele, and Guillermo Rodriguez). 5. Virtual Reality and the Vestibular System: A Brief Review (Erik Viirre, Zsolt Lorant, Mark Draper, and Thomas A. Furness, III). PART II: TELEMEDICINE AND TELESURGERY. 6. Computer Imagery and Multimedia Techniques for Supporting Telemedicine Diagnoses (Qinglian Guo, Katsunobu Muroi, and Mieko Ohsuga). 7. Implementing a Picture-Achieving and Communication System (PACS) and Teleradiology System: Practical Issues and Considerations (Jihong Wang). 8. From Engineering to Surgery: The Harsh Realities of Virtual Reality (Robert John Stone). 9. Maxillofacial Virtual Surgery from 3-D CT Images (Alessandro Sarti, Roberto Gori, Alberto Bianchi, Claudio Marchetti, and Claudio Lamberti). INDEX.

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Book SynopsisIn the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positioTrade Review"...is supported by a wealth of illustrations, tables, and exemplary calculations that will aid in comprehension...[an] excellent and much needed textbook." (The Quarterly Review of Biology, March 2007) "...should be required for anyone who desires to know more about metabolic tracer kinetics." (Journal of the American Society for Mass Spectrometry, September 2005) "...an effective integration of theory and practical implementation...It effectively serves as a teaching textbook as well as a research item." (E-STREAMS, August 2005) Table of ContentsPreface. Chapter 1. Basic Characteristics of Isotopic Tracers. Chapter 2. Calculating Specific Activity and Radiation Dosages. Chapter 3. Calculation of Substance Kinetics: Single-Pool Model. Chapter 4. Calculation of Substrate Kinetics: Multiple-Pool Model. Chapter 5. Mass Spectrometry: Instrumentation. Chapter 6. Determination of Isotopic Enrichment. Chapter 7. Measurement of Substrate Oxidation. Chapter 8. Measurement of Total Energy Expenditure Using the Doubly Labeled Water Method. Chapter 9. Mass Isotopomer Distribution Analysis. Chapter 10. Glucose Metabolism. Chapter 11. Lipid Kinetics. Chapter 12. Whole Body Protein Synthesis and Breakdown. Chapter 13. Measurement of the Synthesis of Specific Proteins. Chapter 14. Measurement of Regional or Tissue Protein Breakdown. Chapter 15. Arterial-Venous Balance Technique to Measure Amino Acid Kinetics. Chapter 16. Nuclear Magnetic Resonance. Glossary. Abbreviations. Index.

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Book SynopsisTelemedicine is one of the fastest growing areas of medical information and services. This book traces its origins, defines its scope, and considers its benefits and limitations. Readers will also learn about the strategic, technical, and operational issues when considering the introduction of telemedicine services.Trade ReviewNorris provides an excellent summary of the telemedicine literature, and much pragmatic advice for those involved in health service implamentation and administration" (British Medical Journal, 4 May 2002) "...Informative and easy to read, it is packed with interesting information and facts. An essential read." (Nursing Times, 18 June 2002) "...The author of this excellent book...has reviewed the subject clearly and thoroughly..." (Family Practice, Vol.19, No.4, 2002) "...explains the main features…potential benefits, and...limitations and barriers." (SciTech Book News, Vol. 26, No. 2, June 2002) "…if you need a detailed working knowledge of the field it will help…" (Primary Health Care, April 2003)Table of ContentsPreface Origins and Development Introduction Definitions of Telemedicine, Telehealth and Telecare Origins and Development of Telemedicine Drivers of Telemedicine and Telecare Telemedicine in Developed and Underdeveloped Countries The Future of Telemedicine Summary Scope, Benefits and Limitations of Telemedicine Introduction Types of Telemedicine Patients and Carers Benefits and Limitations of Telemedicine Barriers to Progress Summary Technology of Telemedicine Systems Introduction Information Types and Transmissions Teleconsultation System Components Telecommunications Options Integration and Operational Issues Summary Telemedicine Service Providers and Applications Introduction Mainstream Health Sector Services Commercial Services and Other Agencies Summary Development and Delivery of Telemedicine Services Introduction The Strategic Context of Service Development The Evaluation of Pilot Studies Developing and Delivering a Telemedicine Service Summary Ethical and Legal Aspects of Telemedicine Introduction Confidentiality, Patient Rights and Consent Data Protection and Security Ethical and Legal Aspects of the Internet Telemedical Malpractice Jurisdictional Issues Intellectual Property Rights Summary Telemedicine Books and Web Sites References Index

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Book SynopsisThe use of ultrasound is increasing rapidly throughout the world, and consequently a knowledge of the underlying scientific principles and instrument operation has become an essential part of medical ultrasound courses.Table of ContentsNature of Ultrasound. Propagation in Tissue. Beam Shapes and Transducers. A-Scan Instruments. Static B-Scan. Real-Time Scanners. M-Mode. Other Scanners and Probes. Measurement of Size. Doppler Ultrasound Physics and Instruments. Doppler Ultrasound Measurement. Digital Storage, Scan Converters and Data Processing. Image Artifacts. Performance Checks. Bioeffects, Dosimetry and Safety. Appendices. Bibliography. Index.

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Book SynopsisAbout this book In recent years, a number of different spectroscopic techniques have been applied to the study of a wide range of biomedical topics.Table of ContentsWhole Cell Studies and Tissue Characterization by RamanSpectroscopy (G. Puppels & J. Greve). Optical Microspectroscopy and Imaging Analysis: Probing Drugs andMetal Ions in Living Cells (G. Sockalingum, et al.). Spectroscopic Studies of Drugs Used in Photodynamic Therapy (D.Phillips, et al.). Biomedical Applications of Raman Spectroscopy: Eye Lens Researchand Cardiovascular Diseases (N.-T. Yu, et al.). FTIR Spectroscopy in the Clinical Sciences (M. Jackson & H.Mantsch). EPR Spectroscopy of Biologically Relevant Free Radicals inCellular, Ex Vivo and In Vivo Systems (M. Davies & G.Timmins). Proton NMR Studies of Oxidative Stress in Disease (C. Spickett, etal.). Applications of High Resolution NMR Analysis to the Study ofInflammatory Diseases at the Molecular Level (M. Grootveld, etal.). Mass Spectroscopy in Structural Biology (R. Gallagher, etal.). Index.

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Book SynopsisWritten by a computer vision specialist, this title offers an account of volumetric image analysis techniques. It offers a practical approach to the field including the following topics: preprocessing of volumetric images; obtaining quantitative measurements in volumetric images; and, detection and modelling of objects in volumetric images.Table of ContentsPreface ix Acknowledgements xi 1 Introduction 1 Part I: 3D Binary Images 7 2 Basics 9 3 Features of 3D Components 43 4 Operations on 3D Binary Images 61 Part II: 3D Grey Level Images 103 5 Image Enhancement 105 6 Geometric Transformations of Voxel Images 117 7 Surface Segmentation 129 8 Region Segmentation 169 Part III: Modelling and Registration of Objects 177 9 Surface Tiling 181 10 Surface Reconstruction 193 11 Registration 203 Appendix 215 A Displaying Volumetric Images 215 References 225 Index 241

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Book SynopsisLearn how to architect ultra low power robust electronics with applications to implantable and non-invasive medicine, and how bio-inspired principles from cell biology and neurobiology can revolutionize low power electronics design, with this all-inclusive guide. Efficient, sustainable energy harvesting is also covered, and a wealth of practical examples and case studies are included.Trade Review'… an excellent overview of ten key fundamental principles related to ultra low power circuit and system design. Examples of many practical, experimental micro-power systems in cardiac, neural,and other medical-electronics applications make the text highly useful. Practitioners in this field will gain insight from his system-level analysis, which is presented at a level deeper than that found in most texts. In fact, the focus on systems thinking and connections made to a diverse set of problems - natural and man-made, from medical implants, to cells, to low-power cars - truly sets this book apart.' Tim Denison, Medtronic Fellow'This truly interdisciplinary book is about much more than circuits. It contains the most comprehensive and deep treatment I have seen of the interplay and parallels between biology and circuits, and of how one discipline can inform the other. The comparisons between analog, digital, and biological implementations are fundamental and highly valuable. The breadth of the book is unique, ranging from feedback and antennas to battery chemistry.' Yannis Tsividis, Columbia University'Sarpeshkar's focus on modeling cells as analog rather than digital circuits offers a new approach that will expand the frontiers of synthetic biology. Rahul has nicely laid a foundation that many of us in synthetic biology will be able to build on.' James Collins, Boston UniversityTable of ContentsPart I. Foundations: Ten chapters lay a foundation in device physics, noise, and feedback systems including nano scales in a highly original fashion, emphasizing intuitive thinking. This foundation is important in designing and analyzing ultra-low-power systems in both electronics and biology; Part II. Low-Power Analog and Biomedical Circuits: Five chapters present building-block circuits that are useful for ultra-low-power biomedical electronics and analog electronic systems in general; Part III. Low-Power RF and Energy-Harvesting Circuits for Biomedical Systems: Three chapters provide an in-depth description of energy-efficient power and data radio-frequency (RF) links that are fundamental to biomedical systems; Part IV. Biomedical Electronic Systems: Two chapters provide an in-depth look at ultra-low-power implantable electronics and ultra-low-power noninvasive electronics for biomedical applications, respectively. Case studies for cochlear implants for the deaf, brain implants for the blind and paralyzed, wearable cardiac devices, and biomolecular sensing are provided; Part V. Principles for Ultra-Low-Power Analog and Digital Design: Two chapters discuss principles for ultra-low-power digital design and ultra-low-power analog and mixed-signal design, respectively. The chapters identify ten fundamental principles that are common in both biology and electronics, analog and digital design; Part VI. Bio-Inspired Systems: A chapter on neuromorphic electronics discusses electronics inspired by neurobiology followed by a chapter that discusses a novel form of electronics termed Cytomorphic Electronics, electronics inspired by cell biology. These chapters discuss applications of bio-inspired systems to engineering and medicine, deep connections between chemistry and electronics, and provide a unifying viewpoint of ultra-low-power design in biology and in electronics; Part VII. Energy Sources: A chapter on batteries and electrochemistry discusses how batteries work from a unique circuit viewpoint. The last chapter discusses energy harvesting in biomedical systems at portable scales (vibration and body heat) and at larger scales (low-power cars and solar cells). Principles of low-power design are shown to extend from small scales in electronics to larger scales and to non-electrical systems. This book reveals the deep connections between energy use and energy generation, vital for sustainable energy systems of the future.

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Book SynopsisThe new edition of this established text has been thoroughly revised and updated. It is divided into six parts. The first two parts cover the X-ray tube and X-ray generators. Part three looks at general, multipurpose radiographic equipment. Part four considers fluroscopic equipment, and the remaining two parts provide accounts of more specialized radiographic equipment and computer-based imaging modalities.Table of ContentsPart 1 The X-Ray Tube - Chapter 1 The X-Ray Tube: X-ray production; Electrical and radiation safety; Focal spot size; The problem of heat; X-ray tube construction and operation; Care of the X-ray tube; Follow-up practical; Part 2 X-Ray Generators - Chapter 2 Control of the X-Ray Tube Kilovoltage: Introduction; Voltage transformation; The high tension primary circuit; The need for rectification; Shortcomings of a pulsating X-ray supply; High tension cables; Kilovoltage compensation; Measuring kilovoltage; Follow-up practical; Chapter 3 Control of X-Ray Tube Current: Introduction; The need for accuracy; Tube filament circuitry; Falling load generators; Tube current measurement and display; Follow-up practical; Chapter 4 Exposure Timing and Switching: Introduction; Exposure switching; Exposure timing; Follow-up practical; Part 3 General, Multipurpose Radiographic Equipment - Chapter 5 Control of Scattered X-Radiation: Introduction; The effects of scattered radiation; Methods of scatter control; Follow-up practical; Chapter 6 Radiographic Couches, Stands and Tube Supports: X-ray tube supports; Radiographic couches; Chest stands and vertical buckys; Modern basic radiographic units; Follow-up practical; Part 4 Fluoroscopic Equipment - Chapter 7 Fluoroscopic Equipment: Introduction; Types of fluoroscopic equipment; Conventional fluoroscopic couches; Mobile and specialized fluoroscopic units; The image intensifier; Television cameras; The television monitor; Image recording; Summary of intensified fluoroscopy; Follow-up clinical; Part 5 Specialised Radiographic Equipment - Chapter 8 Mobile Radiographic Equipment: Introduction; Electrical energy sources; Mains-dependent mobile equipment; Coventional generators; Capacitor discharge equipment; Battery-powered generators; X-ray tubes; Physical features; Follow-up practical; Chapter 9 Accident and Emergency X-Ray Equipment: Introduction; Basic trolley design; Isocentric skull unit with variable height table; Trolley-based system; Trauma resuscitation room; Ancillary equipment; Follow-up practical; Chapter 10 Equipment for Dental Radiography: Intra-oral equipment; Cephalostat (craniostat); Orthopantomography; Follow-up practical; Chapter 11 Mammographic Equipment: Introduction; Mammographic X-ray tubes; Compression; Exposure timing; Breast support plate; Patient reassurance; Follow-up practical; Chapter 12 Equipment for Conventional Tomography: Introduction; Principle; Main features of tomographic equipment; Types of tomographic equipment; Equipment tests; Follow-up practical; Part 6 Computer-Based Imaging Modalities - Chapter 13 Image Digitization: Introduction; The difference between analogue and digital; The benefits of diagnostic image digitization; Follow-up practical; Chapter 14 Computed Tomography: Introduction; The principle of CT; Equipment for CT; The X-ray generator; The table; The operating/display console; The computer; Image quality; Use of CT equipment - the operator's judgement; Follow-up practical; Chapter 15 Radionuclide Imaging: Introduction; Types of radioactivity; Choice of radionuclide; Radiation dosimetry; Technetium; 99m; Equipment; The gamma camera; Follow-up clinical; Chapter 16 Equipment for Ultrasound Imaging: Introduction; Basic functions of ultrasound imaging equipment; The nature of ultrasound and its propagation in human tissue; Interactions of ultrasound energy and tissue; Core modules of ultrasound equipment; Modes of ultrasound imaging; Probes, transducers and ultrasound beam shapes; B-mode, real time, grey scale ultrasound imaging systems; Doppler ultrasound; Safety in ultrasound; Care of ultrasound equipment; Conclusion; Bibliography; Chapter 17 Magnetic Resonance Imaging: Introduction; NMR; The NMR signal; The MR image; MR scanners; Control of the imaging process; The MR system; Safety considerations; The NMR equation; Follow-up practical; Index

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Book SynopsisA guide to the methods used to provide respiratory support in the patient with respiratory failure. It outlines the evolution of different techniques, explains the physiological principles, and evaluates their role in clinical practice. It also includes information on the increasing use of non-invasive techniques.Table of ContentsPreface to first edition. Preface to second edition. Conversion factors, respiratory, and abbreviations used in text. 1.Development of techniques of respiratory support. 2.Physiological background to mechanical ventilation. 3.Mechanical basis of respiratory support. 4.Methods of providing respiratory support. 5.Barotrauma: techniques for reducing peak airway pressure. 6.Modern ventilator technology. 7.Respiratory failure: conservative treatment and indications for providing respiratory support. 8.Selection and care of artificial airways. 9.Care of the patient during respiratory support. 10.Modern ventilator technology. Appendix 1: Suppliers of respiratory support equipment. Index

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Book Synopsis

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Book SynopsisUsing examples drawn from biomedicine and biomedical engineering, this essential reference book brings you comprehensive coverage of all the major techniques currently available to build computer-assisted decision support systems. You will find practical solutions for biomedicine based on current theory and applications of neural networks, artificial intelligence, and other methods for the development of decision aids, including hybrid systems. Neural Networks and Artificial Intelligence for Biomedical Engineering offers students and scientists of biomedical engineering, biomedical informatics, and medical artificial intelligence a deeper understanding of the powerful techniques now in use with a wide range of biomedical applications. Highlighted topics include: Types of neural networks and neural network algorithms Knowledge representation, knowledge acquisition, and reasoning methodologies Chaotic analysis of biomedical time series Table of ContentsPreface. Acknowledgments. Overview. NEURAL NETWORKS. Foundations of Neural Networks. Classes of Neural Networks. Classification Networks and Learning. Supervised Learning. Unsupervised Learning. Design Issues. Comparative Analysis. Validation and Evaluation. ARTIFICIAL INTELLIGENCE. Foundation of Computer-Assisted Decision Making. Knowledge Representation. Knowledge Acquisition. Reasoning Methodologies. Validation and Evaluation. ALTERNATIVE APPROACHES. Genetic Algorithms. Probabilistic Systems. Fuzzy Systems. Hybrid Systems. HyperMerge, a Hybird Expert System. Future Perspectives. Index. About the Authors.

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Book SynopsisOffers professional and executive-level insight into trends and potential technological advances in the field of medicine. This book covers topics ranging from: fundamental advances in computing and administration, research, nursing, and patient care delivery to non-invasive surgery, bio-molecular therapies, bionics, and more.Table of ContentsAbout the Authors v About the References and Notes ix Acknowledgments xi Introduction xiii Part 1 Trends in Technology Chapter 1 The Rate of Change 3 Chapter 2 Fundamental Trends in Technology 17 Chapter 3 Trends in Administration and Control 43 Chapter 4 Advances in Research Methods 69 Chapter 5 Emerging Products and Services 97 Chapter 6 Androids and Cyborgs 121 Chapter 7 Preparing for the Future 139 Part 2 Professional Perspectives Chapter 8 The Process of the Health Care Encounter 155 Chapter 9 Impact of Technology on Nursing Care 181 Chapter 10 Hospitals and the Forces of Change 193 Chapter 11 A Payer's Perspective on the Future 209 Chapter 12 Leadership, Followship, and Science 231 Chapter 13 Epilogue: A Postscript on Progress 251 Index 255

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Book SynopsisIn a concluding chapter he applies the book's historical insights to medical practice today-asking why, for example, modern diagnostic tests have not been used to give doctors more time to spend with patients.Trade Review[Howell's] early twentieth-century portrait is fresh and important, as an analysis of medical practice just coming to grips with the technological world. Nature I recommend this delightful book to anyone interested in the history of medicine. -- Seymour Perry New England Journal of Medicine

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Book SynopsisIntimate epistolary exchanges between Cabot and his patients shed light on the challenges presented by the new technologies-especially their impact on the personal relationships between doctor and patient-providing insight into a time of expanding science and radical change.Trade ReviewA fine book, an engaging example of the best sort of contemporary history... Crenner has provided as much material for the historian as for the historically minded physician... rigorously researched and fascinating. -- Richard Barnett The Lancet 2005 An important reference for readers who are interested in the intellectual and organizational contributions of Richard Cabot... of interest to all who would enjoy an elegant look back at the pathways by which modern medicine has developed. -- Dwight K. Oxley, MD Archives of Pathology and Laboratory Medicine 2006 An informative book. -- Ian Cameron Canadian Family Physician 2006 Private Practice is solid scholarship, a model for students of medical history, a significant contribution for medical historians, and an inspiration for further research. Journal of the History of Medicine and Allied Sciences 2006 An important book, thoroughly researched and documented... Readers interested in the sociology of medicine will find that Cabot's private practice yields new insights. -- David Faflik New England Quarterly 2007Table of ContentsPrefaceAcknowledgementsChapter 1. The Authority of a Scientific DoctorChapter 2. Organizing a Private Office: Between Home and HospitalChapter 3. The Diagnosis of Hidden DiseaseChapter 4. Treatment: How to Know What WorksChapter 5. Nervous Disease and Personal IdentityChapter 6. Medical Care for the Dying, in Principle and in FactChapter 7. From Cabot's Day to Ours: Ideals of the Medical RelationshipNotesIndex

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Book SynopsisA portable study guide for MLS & MLT exams. More than 600 cards concisely summarize common procedures and disorders, critical knowledge for entry-level practice, and cover topics that are frequently included on MLS and MLT certification exams.Table of Contents I.Laboratory Operations, Management, and Education II.Clinical Chemistry III.Clinical Microbiology IV.Hematology V.Immunology VI.Immunohematology VII.Urinalysis and Body Fluids VIII.Molecular Diagnostics

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Book SynopsisBiomedical nanotechnology is one of the fastest-growing fields of research across the globe. However, even the most promising technologies may never realize their full potential if public and political opinions are galvanized against them, a situation clearly evident in such controversial fields as cloning and stem cell research. Biomedical Nanotechnology presents state-of-the-art research in the field and also considers the socio-political risks and perceptions of this important science.Contributed by prominent experts in this expansive and interdisciplinary field, Biomedical Nanotechnology examines developments in three sub-fields: nanodrugs and drug delivery; prostheses and implants; and diagnostics and screening technologies. The authors compare new capabilities introduced by nanotechnology to traditional methods of release, target, and controlled drug delivery in the body. They also consider the challenge of understanding and controlling the biological proTable of ContentsIntroduction: Converging Technologies: Nanotechnology and Biomedicine. Trends in Biomedical Nanotechnology Programs Worldwide. Nanotechnology and Trends in Drug Delivery Systems with Self-Assembled Carriers. Implants and Prostheses. Diagnostics and High Throughput Screening. Nano-Enabled Components and Systems for Biodefense. Social and Economic Contexts: Making Choices in the Development of Biomedical Nanotechnology. Potential Risks and Remedies. Index.

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Book SynopsisTwo of the most important yet often overlooked aspects of a medical device are its usability and accessibility. This is important not only for health care providers, but also for older patients and users with disabilities or activity limitations. Medical Instrumentation: Accessibility and Usability Considerations focuses on how lack of usability and accessibility pose problems for designers and users of medical devices, and how to overcome these limitations. Divided into five broad sections, the book first addresses the nature and extent of the problem by identifying access barriers, human factors, and policy issues focused on the existing infrastructure. The subsequent sections examine responses to the problem, beginning with tools for usability and accessibility analysis and principles of design for medical instrumentation. Building on this foundation, the third section focuses on recommendations for design guidelines while the fourth section explores emerging trends andTable of ContentsBackground: The Problem, Existing Infrastructure, and Possible Solutions. Tools for Usability and Accessibility Analysis. Considerations in Design Guideline Development. Considerations in Emerging Trends and Technologies. Outputs of the Workshop: Key Knowledge Gaps, Barriers, Recommendations. Appendices. Glossary of Terms.

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Book SynopsisFrom its initial clinical use, over 28 years ago, to its current extensive use (over 100,000 times annually in the US alone), balloon pump equipment has developed into sophisticated, computer--assisted technology for mechanically aiding circulation.Trade Review"...well written and well organized. It should be welcome as a reference text to the libraries of multidisciplinary teams caring for cardiac patients." --Canadian Journal of Surgery "This book presents a comprehensive and up to date review of the use of the intra-aortic balloon pump (IABP) ...The sections on balloon pump equipment, consoles and catheters, and the physiology of balloon pumping are all particularly good, and perhaps should be mandatory reading for all trainees in cardiac surgery, cardiac anesthesia, invasive cardiology and clinical perfusion. "It is a worthwhile addition to the library of a busy cardiovascular critical care unit in which IABPs are used frequently, and is a good reference text for anyone who is considering research involving the IABP." --Canadian Journal of AnesthesiaTable of ContentsSection I: Assisted Circulation. 1. The Principle of Circulatory Assist. 2. Pulsatile Assist Devices and Counterpulsation. Section II: Cardiac Function and Pathophysiology of Cardiac Failure. 3. Cardiac Function and Classification Of Cardiac Failure. 4. Cardiogenic Shock. Section III: The Intra-Aortic Balloon Pump. 5. Historical Background. 6. Balloon Pump Equipment. 7. Balloon Pump Consoles and Catheters. 8. Physiology of Balloon Pumping. 9. General Criteria, Contraindications and Guidelines for Balloon Pumping. 10. Methods of Insertion and Removal of Intra-Aortic Balloon Catheter. 11. Complications of Balloon Pumping. Section IV: Management of Patients on Intra-Aortic Balloon Pump. 12. Nursing Care Of Patients on Intra-Aortic Balloon Pump. 13. Hemodynamic Monitoring, Data Acquisition and Assessment of Efficacy of Diastolic Augmentation. 14. Pharmacologic Treatment. 15. Management of Patients on Intra-Aortic Balloon Pump in Special Situations. 16. Problems With Use of Balloon Pumping. 17. Weaning from Intra-Aortic Balloon Pump Assist. 18. System Management in Patients on Intra-Aortic Balloon Pump. 19. Ancillary Measures in Care of Patients on Intra-Aortic Balloon Pump. Section V: Indications for Use of Intra-Aortic Balloon Pump. 20. An Overview. 21. Intra-Aortic Balloon Pump for Coronary Artery Disease. 22. Balloon Pumping in Cardiogenic Shock. 22. Balloon Pumping in Cardiac Surgery. 23. Miscellaneous Indications for Balloon Pumping

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Book SynopsisThere are many excellent textbooks that exist in the area of implantable devices for arrhythmia control. Few textbooks, however, provide a case study approach. Collectively, these workbooks provide an approach to problem solving an electrocardiographic interpretation for patients with permanent pacemakers and defibrillators. Volume 1 addresses patients with permanent pacemakers Volume 2 examines interactions between pacemakers and implantable defibrillators Volume 3 provides case studies of transtelephonic pacemakers electrocardiography Volume 4 provides more pacemaker and implantable defibrillator troubleshooting cases This volume takes a case-orientated approach, providing a diverse series of problems on a broad range of topics related to implantable defibrillators. The cases are divided into easy, moderate and complex according to their level of difficulty, allowing the reader to gauge their progress. This workbook is suitable for physicians, nurses, tecTrade Review"This volume (2) throughly covers the potential problems with implantable defibrillators with provocative problems combined with clear solutions." Doody's Review Service "In summary, these workbooks provide a case-oriented approach to identifying and managing both simple and more complex problems frequently encountered in patients with implantable defibrillators. These workbooks are best suited to individuals new in the fields of pacing and electrophysiology." Canadian Journal of CardiologyTable of ContentsVolume 1: Cardiac Pacing: A Case Approach. Volume 2: Implantable Defibrillators: A Case Approach. Volume 3: Transtelephonic, Electrocardiography and Troubleshooting: A Case Approach. Volume 4: ICDs and Pacemakers

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Book SynopsisEasy to understand and richly illustrated, this essential guide introduces the basics of critical care EEG, including continuous EEG monitoring, to acute care providers of all backgrounds and skill levels, enabling them to harness the full potential of this technique for the benefit of patients.

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Book SynopsisEmerging Technologies for Healthcare begins with an IoT-based solution for the automated healthcare sector which is enhanced to provide solutions with advanced deep learning techniques. The book provides feasible solutions through various machine learning approaches and applies them to disease analysis and prediction. An example of this is employing a three-dimensional matrix approach for treating chronic kidney disease, the diagnosis and prognostication of acquired demyelinating syndrome (ADS) and autism spectrum disorder, and the detection of pneumonia. In addition, it provides healthcare solutions for post COVID-19 outbreaks through various suitable approaches, Moreover, a detailed detection mechanism is discussed which is used to devise solutions for predicting personality through handwriting recognition; and novel approaches for sentiment analysis are also discussed with sufficient data and its dimensions. This book not only covers theoretical approaches and algorTable of ContentsPreface xvii Part I: Basics of Smart Healthcare 1 1 An Overview of IoT in Health Sectors 3Sheeba P. S. 1.1 Introduction 3 1.2 Influence of IoT in Healthcare Systems 6 1.2.1 Health Monitoring 6 1.2.2 Smart Hospitals 7 1.2.3 Tracking Patients 7 1.2.4 Transparent Insurance Claims 8 1.2.5 Healthier Cities 8 1.2.6 Research in Health Sector 8 1.3 Popular IoT Healthcare Devices 9 1.3.1 Hearables 9 1.3.2 Moodables 9 1.3.3 Ingestible Sensors 9 1.3.4 Computer Vision 10 1.3.5 Charting in Healthcare 10 1.4 Benefits of IoT 10 1.4.1 Reduction in Cost 10 1.4.2 Quick Diagnosis and Improved Treatment 10 1.4.3 Management of Equipment and Medicines 11 1.4.4 Error Reduction 11 1.4.5 Data Assortment and Analysis 11 1.4.6 Tracking and Alerts 11 1.4.7 Remote Medical Assistance 11 1.5 Challenges of IoT 12 1.5.1 Privacy and Data Security 12 1.5.2 Multiple Devices and Protocols Integration 12 1.5.3 Huge Data and Accuracy 12 1.5.4 Underdeveloped 12 1.5.5 Updating the Software Regularly 12 1.5.6 Global Healthcare Regulations 13 1.5.7 Cost 13 1.6 Disadvantages of IoT 13 1.6.1 Privacy 13 1.6.2 Access by Unauthorized Persons 13 1.7 Applications of IoT 13 1.7.1 Monitoring of Patients Remotely 13 1.7.2 Management of Hospital Operations 14 1.7.3 Monitoring of Glucose 14 1.7.4 Sensor Connected Inhaler 15 1.7.5 Interoperability 15 1.7.6 Connected Contact Lens 15 1.7.7 Hearing Aid 16 1.7.8 Coagulation of Blood 16 1.7.9 Depression Detection 16 1.7.10 Detection of Cancer 17 1.7.11 Monitoring Parkinson Patient 17 1.7.12 Ingestible Sensors 18 1.7.13 Surgery by Robotic Devices 18 1.7.14 Hand Sanitizing 18 1.7.15 Efficient Drug Management 19 1.7.16 Smart Sole 19 1.7.17 Body Scanning 19 1.7.18 Medical Waste Management 20 1.7.19 Monitoring the Heart Rate 20 1.7.20 Robot Nurse 20 1.8 Global Smart Healthcare Market 21 1.9 Recent Trends and Discussions 22 1.10 Conclusion 23 References 23 2 IoT-Based Solutions for Smart Healthcare 25Pankaj Jain, Sonia F Panesar, Bableen Flora Talwar and Mahesh Kumar Sah 2.1 Introduction 26 2.1.1 Process Flow of Smart Healthcare System 26 2.1.1.1 Data Source 26 2.1.1.2 Data Acquisition 27 2.1.1.3 Data Pre-Processing 27 2.1.1.4 Data Segmentation 28 2.1.1.5 Feature Extraction 28 2.1.1.6 Data Analytics 28 2.2 IoT Smart Healthcare System 29 2.2.1 System Architecture 30 2.2.1.1 Stage 1: Perception Layer 30 2.2.1.2 Stage 2: Network Layer 32 2.2.1.3 Stage 3: Data Processing Layer 32 2.2.1.4 Stage 4: Application Layer 33 2.3 Locally and Cloud-Based IoT Architecture 33 2.3.1 System Architecture 33 2.3.1.1 Body Area Network (BAN) 34 2.3.1.2 Smart Server 34 2.3.1.3 Care Unit 35 2.4 Cloud Computing 35 2.4.1 Infrastructure as a Service (IaaS) 37 2.4.2 Platform as a Service (PaaS) 37 2.4.3 Software as a Service (SaaS) 37 2.4.4 Types of Cloud Computing 37 2.4.4.1 Public Cloud 37 2.4.4.2 Private Cloud 38 2.4.4.3 Hybrid Cloud 38 2.4.4.4 Community Cloud 38 2.5 Outbreak of Arduino Board 38 2.6 Applications of Smart Healthcare System 39 2.6.1 Disease Diagnosis and Treatment 41 2.6.2 Health Risk Monitoring 42 2.6.3 Voice Assistants 42 2.6.4 Smart Hospital 42 2.6.5 Assist in Research and Development 43 2.7 Smart Wearables and Apps 43 2.8 Deep Learning in Biomedical 44 2.8.1 Deep Learning 46 2.8.2 Deep Neural Network Architecture 47 2.8.3 Deep Learning in Bioinformatic 49 2.8.4 Deep Learning in Bioimaging 49 2.8.5 Deep Learning in Medical Imaging 50 2.8.6 Deep Learning in Human-Machine Interface 53 2.8.7 Deep Learning in Health Service Management 53 2.9 Conclusion 55 References 55 3 QLattice Environment and Feyn QGraph Models—A New Perspective Toward Deep Learning 69Vinayak Bharadi 3.1 Introduction 70 3.1.1 Machine Learning Models 70 3.2 Machine Learning Model Lifecycle 71 3.2.1 Steps in Machine Learning Lifecycle 71 3.2.1.1 Data Preparation 72 3.2.1.2 Building the Machine Learning Model 72 3.2.1.3 Model Training 72 3.2.1.4 Parameter Selection 72 3.2.1.5 Transfer Learning 73 3.2.1.6 Model Verification 73 3.2.1.7 Model Deployment 74 3.2.1.8 Monitoring 74 3.3 A Model Deployment in Keras 75 3.3.1 Pima Indian Diabetes Dataset 75 3.3.2 Multi-Layered Perceptron Implementation in Keras 76 3.3.3 Multi-Layered Perceptron Implementation With Dropout and Added Noise 77 3.4 QLattice Environment 80 3.4.1 Feyn Models 80 3.4.1.1 Semantic Types 82 3.4.1.2 Interactions 83 3.4.1.3 Generating QLattice 83 3.4.2 QLattice Workflow 83 3.4.2.1 Preparing the Data 84 3.4.2.2 Connecting to QLattice 84 3.4.2.3 Generating QGraphs 84 3.4.2.4 Fitting, Sorting, and Updating QGraphs 85 3.4.2.5 Model Evaluation 86 3.5 Using QLattice Environment and QGraph Models for COVID-19 Impact Prediction 87 References 91 4 Sensitive Healthcare Data: Privacy and Security Issues and Proposed Solutions 93Abhishek Vyas, Satheesh Abimannan and Ren-Hung Hwang 4.1 Introduction 94 4.1.1 Types of Technologies Used in Healthcare Industry 94 4.1.2 Technical Differences Between Security and Privacy 95 4.1.3 HIPAA Compliance 95 4.2 Medical Sensor Networks/Medical Internet of Things/Body Area Networks/WBANs 97 4.2.1 Security and Privacy Issues in WBANs/WMSNs/WMIOTs 101 4.3 Cloud Storage and Computing on Sensitive Healthcare Data 112 4.3.1 Security and Privacy in Cloud Computing and Storage for Sensitive Healthcare Data 114 4.4 Blockchain for Security and Privacy Enhancement in Sensitive Healthcare Data 119 4.5 Artificial Intelligence, Machine Learning, and Big Data in Healthcare and Its Efficacy in Security and Privacy of Sensitive Healthcare Data 122 4.5.1 Differential Privacy for Preserving Privacy of Big Medical Healthcare Data and for Its Analytics 124 4.6 Conclusion 124 References 125 Part II: Employment of Machine Learning in Disease Detection 129 5 Diabetes Prediction Model Based on Machine Learning 131Ayush Kumar Gupta, Sourabh Yadav, Priyanka Bhartiya and Divesh Gupta 5.1 Introduction 131 5.2 Literature Review 133 5.3 Proposed Methodology 135 5.3.1 Data Accommodation 135 5.3.1.1 Data Collection 135 5.3.1.2 Data Preparation 136 5.3.2 Model Training 138 5.3.2.1 K Nearest Neighbor Classification Technique 139 5.3.2.2 Support Vector Machine 140 5.3.2.3 Random Forest Algorithm 142 5.3.2.4 Logistic Regression 144 5.3.3 Model Evaluation 145 5.3.4 User Interaction 145 5.3.4.1 User Inputs 146 5.3.4.2 Validation Using Classifier Model 146 5.3.4.3 Truth Probability 146 5.4 System Implementation 147 5.5 Conclusion 153 References 153 6 Lung Cancer Detection Using 3D CNN Based on Deep Learning 157Siddhant Panda, Vasudha Chhetri, Vikas Kumar Jaiswal and Sourabh Yadav 6.1 Introduction 157 6.2 Literature Review 159 6.3 Proposed Methodology 161 6.3.1 Data Handling 161 6.3.1.1 Data Gathering 161 6.3.1.2 Data Pre-Processing 162 6.3.2 Data Visualization and Data Split 162 6.3.2.1 Data Visualization 162 6.3.2.2 Data Split 162 6.3.3 Model Training 163 6.3.3.1 Training Neural Network 163 6.3.3.2 Model Optimization 166 6.4 Results and Discussion 168 6.4.1 Gathering and Pre-Processing of Data 169 6.4.1.1 Gathering and Handling Data 169 6.4.1.2 Pre-Processing of Data 170 6.4.2 Data Visualization 171 6.4.2.1 Resampling 173 6.4.2.2 3D Plotting Scan 173 6.4.2.3 Lung Segmentation 173 6.4.3 Training and Testing of Data in 3D Architecture 175 6.5 Conclusion 178 References 178 7 Pneumonia Detection Using CNN and ANN Based on Deep Learning Approach 181Priyanka Bhartiya, Sourabh Yadav, Ayush Gupta and Divesh Gupta 7.1 Introduction 182 7.2 Literature Review 183 7.3 Proposed Methodology 185 7.3.1 Data Gathering 185 7.3.1.1 Data Collection 185 7.3.1.2 Data Pre-Processing 186 7.3.1.3 Data Split 186 7.3.2 Model Training 187 7.3.2.1 Training of Convolutional Neural Network 189 7.3.2.2 Training of Artificial Neural Network 191 7.3.3 Model Fitting 193 7.3.3.1 Fit Generator 193 7.3.3.2 Validation of Accuracy and Loss Plot 193 7.3.3.3 Testing and Prediction 193 7.4 System Implementation 194 7.4.1 Data Gathering, Pre-Processing, and Split 194 7.4.1.1 Data Gathering 194 7.4.1.2 Data Pre-Processing 195 7.4.1.3 Data Split 196 7.4.2 Model Building 196 7.4.3 Model Fitting 197 7.4.3.1 Fit Generator 197 7.4.3.2 Validation of Accuracy and Loss Plot 197 7.4.3.3 Testing and Prediction 198 7.5 Conclusion 199 References 199 8 Personality Prediction and Handwriting Recognition Using Machine Learning 203Vishal Patil and Harsh Mathur 8.1 Introduction to the System 204 8.1.1 Assumptions and Limitations 206 8.1.1.1 Assumptions 206 8.1.1.2 Limitations 206 8.1.2 Practical Needs 206 8.1.3 Non-Functional Needs 206 8.1.4 Specifications for Hardware 207 8.1.5 Specifications for Applications 207 8.1.6 Targets 207 8.1.7 Outcomes 207 8.2 Literature Survey 208 8.2.1 Computerized Human Behavior Identification Through Handwriting Samples 208 8.2.2 Behavior Prediction Through Handwriting Analysis 209 8.2.3 Handwriting Sample Analysis for a Finding of Personality Using Machine Learning Algorithms 209 8.2.4 Personality Detection Using Handwriting Analysis 210 8.2.5 Automatic Predict Personality Based on Structure of Handwriting 210 8.2.6 Personality Identification Through Handwriting Analysis: A Review 210 8.2.7 Text Independent Writer Identification Using Convolutional Neural Network 210 8.2.8 Writer Identification Using Machine Learning Approaches 211 8.2.9 Writer Identification from HandwrittenText Lines 211 8.3 Theory 212 8.3.1 Pre-Processing 212 8.3.2 Personality Analysis 215 8.3.3 Personality Characteristics 216 8.3.4 Writer Identification 217 8.3.5 Features Used 219 8.4 Algorithm To Be Used 220 8.5 Proposed Methodology 224 8.5.1 System Flow 225 8.6 Algorithms vs. Accuracy 226 8.6.1 Implementation 228 8.7 Experimental Results 231 8.8 Conclusion 232 8.9 Conclusion and Future Scope 232 Acknowledgment 232 References 233 9 Risk Mitigation in Children With Autism Spectrum Disorder Using Brain Source Localization 237Joy Karan Singh, Deepti Kakkar and Tanu Wadhera 9.1 Introduction 238 9.2 Risk Factors Related to Autism 239 9.2.1 Assistive Technologies for Autism 240 9.2.2 Functional Connectivity as a Biomarker for Autism 241 9.2.3 Early Intervention and Diagnosis 242 9.3 Materials and Methodology 243 9.3.1 Subjects 243 9.3.2 Methods 243 9.3.3 Data Acquisition and Processing 243 9.3.4 sLORETA as a Diagnostic Tool 244 9.4 Results and Discussion 245 9.5 Conclusion and Future Scope 247 References 247 10 Predicting Chronic Kidney Disease Using Machine Learning 251Monika Gupta and Parul Gupta 10.1 Introduction 252 10.2 Machine Learning Techniques for Prediction of Kidney Failure 253 10.2.1 Analysis and Empirical Learning 254 10.2.2 Supervised Learning 255 10.2.3 Unsupervised Learning 256 10.2.3.1 Understanding and Visualization 257 10.2.3.2 Odd Detection 257 10.2.3.3 Object Completion 258 10.2.3.4 Information Acquisition 258 10.2.3.5 Data Compression 258 10.2.3.6 Capital Market 258 10.2.4 Classification 259 10.2.4.1 Training Process 260 10.2.4.2 Testing Process 260 10.2.5 Decision Tree 261 10.2.6 Regression Analysis 263 10.2.6.1 Logistic Regression 263 10.2.6.2 Ordinal Logistic Regression 265 10.2.6.3 Estimating Parameters 266 10.2.6.4 Multivariate Regression 268 10.3 Data Sources 269 10.4 Data Analysis 272 10.5 Conclusion 274 10.6 Future Scope 274 References 274 Part III: Advanced Applications of Machine Learning in Healthcare 279 11 Behavioral Modeling Using Deep Neural Network Framework for ASD Diagnosis and Prognosis 281Tanu Wadhera, Deepti Kakkar and Rajneesh Rani 11.1 Introduction 282 11.2 Automated Diagnosis of ASD 284 11.2.1 Deep Learning 289 11.2.2 Deep Learning in ASD 290 11.2.3 Transfer Learning Approach 290 11.3 Purpose of the Chapter 292 11.4 Proposed Diagnosis System 293 11.5 Conclusion 294 References 295 12 Random Forest Application of Twitter Data Sentiment Analysis in Online Social Network Prediction 299Arnav Munshi, M. Arvindhan and Thirunavukkarasu K. 12.1 Introduction 300 12.1.1 Motivation 300 12.1.2 Domain Introduction 300 12.2 Literature Survey 302 12.3 Proposed Methodology 304 12.4 Implementation 311 12.5 Conclusion 311 References 311 13 Remedy to COVID-19: Social Distancing Analyzer 315Sourabh Yadav 13.1 Introduction 315 13.2 Literature Review 318 13.3 Proposed Methodology 321 13.3.1 Person Detection 321 13.3.1.1 Frame Creation 324 13.3.1.2 Contour Detection 325 13.3.1.3 Matching with COCO Model 326 13.3.2 Distance Calculation 326 13.3.2.1 Calculation of Centroid 326 13.3.2.2 Distance Among Adjacent Centroids 327 13.4 System Implementation 328 13.5 Conclusion 333 References 334 14 IoT-Enabled Vehicle Assistance System of Highway Resourcing for Smart Healthcare and Sustainability 337Shubham Joshi and Radha Krishna Rambola 14.1 Introduction 338 14.2 Related Work 340 14.2.1 Adoption of IoT in Vehicle to Ensure Driver Safety 341 14.2.2 IoT in Healthcare System 341 14.2.3 The Technology Used in Assistance Systems 343 14.2.3.1 Adaptive Cruise Control (ACC) 343 14.2.3.2 Lane Departure Warning 343 14.2.3.3 Parking Assistance 343 14.2.3.4 Collision Avoidance System 343 14.2.3.5 Driver Drowsiness Detection 344 14.2.3.6 Automotive Night Vision 344 14.3 Objectives, Context, and Ethical Approval 344 14.4 Technical Background 345 14.4.1 IoT With Health 345 14.4.2 Machine-to-Machine (M2M) Communication 345 14.4.3 Device-to-Device (D2D) Communication 345 14.4.4 Wireless Sensor Network 346 14.4.5 Crowdsensing 346 14.5 IoT Infrastructural Components for Vehicle Assistance System 346 14.5.1 Communication Technology 346 14.5.2 Sensor Network 347 14.5.3 Infrastructural Component 348 14.5.4 Human Health Detection by Sensors 348 14.6 IoT-Enabled Vehicle Assistance System of Highway Resourcing for Smart Healthcare and Sustainability 349 14.7 Challenges in Implementation 353 14.8 Conclusion 353 References 354 15 Aids of Machine Learning for Additively Manufactured Bone Scaffold 359Nimisha Rahul Shirbhate and Sanjay Bokade 15.1 Introduction 360 15.1.1 Bone Scaffold 360 15.1.2 Bone Grafting 362 15.1.3 Comparison Bone Grafting and Bone Scaffold 363 15.2 Research Background 364 15.3 Statement of Problem 364 15.4 Research Gap 365 15.5 Significance of Research 366 15.6 Outline of Research Methodology 366 15.6.1 Customized Design of Bone Scaffold 366 15.6.2 Manufacturing Methods and Biocompatible Material 367 15.6.2.1 Conventional Scaffold Fabrication 368 15.6.2.2 Additive Manufacturing 369 15.6.2.3 Application of Additive Manufacturing/3D Printing in Healthcare 370 15.6.2.4 Automated Process Monitoring in 3D Printing Using Supervised Machine Learning 376 15.7 Conclusion 377 References 377 Index 381

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Book SynopsisAnna Tarrant's revealing research explores the dynamics and diversity of men's caring roles in low-income households at various stages of their lives. It sheds light on men's participation in care and the factors that affect it, including class, culture, work and the impact of austerity.Trade Review''This book presents a compelling account of people's engagements with biosensors. Drawing on their long experience of research in science and technology studies, the authors elucidate how people can be helped or disappointed by these new technologies.'' * Deborah Lupton, University of New South Wales *Table of Contents1. Introduction: Fathering, poverty, families and policy 2. Low-income fatherhoods in historical and political context 3. Theorising men’s participation in low-income families 4. Supporting men in low- income contexts: practitioner observations 5. Men’s caring arrangements and family trajectories 6. Familial economic circumstances and provisioning practices 7. Men’s family participation in low-income urban neighbourhoods 8. Conclusion: Men’s family participation in low-income contexts

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