Intensive care medicine Books

Book SynopsisThis concise, accessible book covers anesthesia for hepatico-pancreatic-biliary (HPB) surgery and transplantation, based on randomized clinical trials, meta-analyses, case series, reports, and hands-on experience. The anatomy, physiology, pathophysiology and clinical consequences are discussed, and the close ties between HPB resection and transplant anesthesia are explored. The content reflects current real-world practice, as liver and pancreatic transplant surgeries have substantially improved in terms of blood-loss reduction, fast tracking and reduced risk. The book also addresses anesthetic aspects in connection with the recently introduced and rapidly expanding practice of laparoscopic surgery; with enhanced recovery; and with pancreatic surgery. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation is intended for aspiring HPB and transplant anesthetists, anesthesia trainees, and consultants with experience in HPB anesthesia who want to see whether or not they’re up to date on the current standards. Trade Review“The editors and publishers have aimed this book at a wider audience than just those specializing in liver transplant and specialist hepatobiliary anesthesia. … This book is at its best when recounting the authors’ real-world practice, which feels up-to-date and evidence-based. Anesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation will be a welcome addition to the shelves of the world’s transplant centers, but it should also find a home on less lofty shelves.” (Nicholas Weston and David W. Hewson, Anesthesia & Analgesia, Vol. 132 (6), June, 2021)“This book makes an excellent read not only for the budding hepato-pancreato-biliary anaesthetists amongst us, but also as a worthy aide memoire for those experienced in HPB anaesthesia who want to see whether they are up to date with the current standards.” (Ned Gilbert-Kawai, EJA European Journal of Anaesthesiology, Vol. 38 (5), 2021)Table of Contents​Part 1: Anatomy and Physiology of the Liver.- 1. Anatomy of HepatoPancreatoBiliary Surgery and Liver Transplantation Relevant to Anaesthesia.- 2. Anatomy and physiology of the liver.- Part 2: Liver transplantation.- 3. Pathophysiology behind cardiopulmonary complications of cirrhosis and portal hypertension.- 4. Liver Transplantation: Graft Variables.- 5. Surgical aspects of liver transplantation.- 6. PRE-ASSESSMENT FOR HEPATO-PANCREATO-BILIARY AND LIVER TRANSPLANT SURGERY.- 7. The Role of Cardiopulmonary Exercise Testing (CPET) in the Preoperative Assessment of Patients for Hepatico-Pancreatic-Biliary (HPB) Surgery and Liver Transplantation (LT).- 8. ANAESTHESIA for LIVER TRANSPLANTATION.- 9. How does the aetiology of primary liver disease affect anaesthesia for liver transplantation.- 10. Haemodynamic monitoring during liver transplant surgery.- 11. Point of care viscoelastic haemostasis monitoring during liver transplant surgery.- 12. HOW TO REDUCE BLEEDING AND BLOOD TRANSFUSION DURING LIVER TRANSPLANTATION.- 13. Fast tracking in liver transplant programme.- 14. Acute kidney injury in hepatico-pancreatic-biliary surgery and liver transplantation .- 15. Use of Extracorporeal Membrane Oxygenation during Liver Transplantation.- 16. Liver preservation with extracorporeal perfusion.- 17. Veno-venous bypass in liver transplantation.- Part 3: Liver resection.- 18. Biology of liver tumors and outcomes of liver surgery.- 19. Anaesthesia for Live Donor Hepatectomy.- 20. Strategies for low central venous pressure in liver resection surgery.- 21. ENHANCED RECOVER AFTER HPB SURGERY.- 22. Postoperative analgesia in liver resection surgery.- Part 4: Pancreas.- 23. Anatomy of liver resection surgery.- 24. Perioperative anaesthetic considerations for the Whipple procedure and other pancreatic surgeries.- 25. Anaesthetic management for patients undergoing pancreas transplantation.- Part 4: Paediatric.- 26. Anaesthesia for Paediatric Liver Surgery.- 27. Anaesthesia for Paediatric Liver Transplantation.- 28. Anaesthesia for Hepatico-Pancreatic-Biliary Surgery and Transplantation Communication between HPB anaesthetists: meetings, websites and forums.

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Book SynopsisThe 2nd edition of this book describes the recent techniques, strategies, and drugs that have been demonstrated by multicenter randomized trials to influence survival in critically ill, defined as those who have acute failure of at least one organ, due to either a pathological condition or a medical intervention, and require intensive care treatment. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as noninvasive mechanical ventilation, protective ventilation, prone positioning, intravenous salbutamol in ARDS, high-frequency oscillatory ventilation, mild hypothermia after cardiac arrest, daily interruption of sedatives, tranexamic acid, diaspirin cross-linked hemoglobin, albumin, growth hormone, glutamine supplementation, tight glucose control, supranormal oxygen delivery, and hydroxyethyl starch in sepsis. The topics selection was performed with the help of hundreds of specialists from dozens of countries; they expressed via web if they agreed or not with these topics and if they used them in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in Critically Ill Patients is of interest for a wide variety of specialists, including intensivists, emergency doctors, and anesthesiologists.Table of ContentsThe process of consensus building.- Non-invasive ventilation.- High Flow Nasal Cannulae.- Restrictive inspiratory oxygen fraction.- Mechanical ventilation.- Early tracheostomy.- Pharmacological Managment of cardiac arrest.- Non pharmacological Managment of cardiac arrest.- Avoidance of deep sedation.- Hydrocortisone in sepsis; Goal directed therapy.- Levosimendan in cardiogenic shock and low cardiac output syndrome.- Drugs in myocardial infarction.- Tranexamic acid in trauma patients.- Procalcitonin-guided antibiotic discontinuation.- Selective decontamination of digestive tract.- Nutrition.- ECMO.- Ultrasound.- Alternative medicine.- Interventions increasing mortality.- Conflicting.- Latest evidences.

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Book SynopsisThis book aims to give a comprehensive overview of the current challenges and solution posed to the health care professionals who need to use mechanical ventilation to treat their patients.Mechanical ventilation is a cornerstone of the treatment of critically ill patients, as also dramatically underlined by the recent COVID-19 pandemic. The topic is not simple to approach, since it requires integration of multiple data which, in turn, result from complex interplays between patient’s condition and ventilatory settings. While technological development empowered advanced monitoring and decision support, these also increase the burden of data on the practitioners. Furthermore, considering that sometimes mechanical ventilation is seen under two, apparently opposite, approaches, “physiology vs. protocols”, the book aims to reconcile these two aspects. And this has been done by each author following the above trajectory in their chapters. The exposure of the topic begins from the “pathophysiology” (i.e. the “physiology of the disease”) so that the reader can better understand the concept and rationale of any given approach. At the same time, any rationale or hypothesis (for as much as supported by physiology) must hold at the proof of clinical research and evidence, which is summarized in each chapter.In summary, the purposes is that the readers understand not only which is the best clinical practice to adopt but also why and which mechanisms this is based upon and how to approach a novel issue they might encounter. The book – addressed to physicians, nurses and respiratory therapist – features chapters on “novel” or “hot” topics like, obviously, COVID-19, ECMO, but also MV in low resource setting.Table of ContentsPart 1. Techniques.- Chapter 1. Basic physiology of respiratory system: gas exchange and respiratory mechanics.- Chapter 2. A short history of Mechanical Ventilation.- Chapter 3. Airway management in critically ill.- Chapter 4. Controlled mechanical ventilation: modes and monitoring.- Chapter 5. Assisted ventilation: pressure support and bilevel ventilation modes.- Chapter 6. Monitoring the patient during assisted ventilation.- Chapter 7. Neurally Adjusted Ventilatory Assist.- Chapter 8. roportional Assist Ventilation.- Chapter 9. Non-invasive ventilation: indications and caveats.- Chapter 10. High-flow Nasal Cannula.- Chapter 11. Nursing of mechanically ventilated and ECMO patient.- Chapter 12. Closed Loop ventilation modes.- Chapter 13. Aiway pressure release ventilation.- Part 2. Clinical Scearios.- Chapter 14. Acute Respiratory Failure and Acute Respiratory Distress Syndrome.- Chapter 15. Ventilator Induced Lung Injury and Lung Protective Ventilation.- Chapter 16. Mechanical ventilation in the heathy lung: OR and ICU.- Chapter 17. PEEP setting in ARDS.- Chapter 18. Ventilation in brain injured patient.- Chapter 19. Invaisve and noninvasive ventilation in patient with cardiac failure.- Chapter 20. COPD and severe asthma.- Chapter 21. Ventilation in the obese patient.- Chapter 22. Weaning the simple and complex patients.- Chapter 23. Noninvasive ventilation in COVID-19.- Chapter 24. Invasive Ventilation in COVID-19.- Chapter 25. Mechanical ventilation in different surgical settings.- Chapter 26. Following up the patients at long term.- Chapter 27. Mechanical Ventilation in limited resource settings.- Chapter 28. Mechanical Ventilation during patient's trasferral.- Part 3. Adjuncts to MV.- Chapter 29. Prone Position.- Chapter 30. Veno-Venous ECMO and ECCO2R.- Chapter 31. Mechanical Ventilation setting during ECMO.- Part 4. Monitoring.- Chapter 32. Ultrasound assesment of the respiratory system.- Chapter 33. Electrical Impedance Tomography.- Chapter 34. Esophageal pressure monitoring.- Chapter 35. Lung Volumes and volumetric capnography.- Chapter 36. Radiological monitoring.- Chapter 37. Clinical vignettes (waveforms).- Chapter 38. Teaching Mechanical ventilation: on line resources and simulation.

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Book SynopsisDieses Kompendium ist ein aktueller Beitrag zur Aerosoltherapie und gibt einen kurzen Überblick über die Anatomie der Lunge, die zur Therapie eingesetzten Aerosole und deren Produktionsverfahren. Der Schwerpunkt liegt aber auf der möglichen Nutzung eines Morphinaerosols zur Schmerzbekämpfung. Die dargestellten klinischen Erfahrungen weisen nur auf den additiven Stellenwert dieser Methode im Rahmen der Schmerzbehandlung hin. Die tierexperimentellen Untersuchungsergebnisse ermöglichen dagegen hinsichtlich der Pharmakokinetik bei der Resorption durch Inhalation und hinsichtlich der Lungenprotektion bei Langzeitbeatmung neue Ansätze.Table of Contents1 Der Atmungsapparat.- 1.1 Die luftleitenden Atemwege.- 1.2 Die Lungen.- 2 Zur pulmonalen Resorption.- 3 Drogenaerosole.- 3.1 Therapie mit Drogenaerosolen.- 3.2 Erzeugung von Aerosolen und praktische Aspekte der Aerosolbehandlung.- 4 Postoperative Schmerzbehandlung mit einem Morphinaerosol.- 4.1 Behandlung nach kardiochirurgischen Operationen.- 4.2 Behandlung nach Abdominaloperationen.- 4.3 Relative Bioverfügbarkeit inhalierten Morphins.- 5 Tierexperimentelle Untersuchungen bei Hunden zur Inhalation von Morphin- und Somatostatinaerosolen.- 5.1 Konzentrationen von Morphin und Somatostatin im Serum.- 5.2 Evaluierung der oszillierenden pulmonalen Resorption.- 5.3 Histologische Begutachtung von Organteilen.- 6 Tierexperimentelle Untersuchungen bei Ratten zur Inhalation von Morphin- und Somatostatinaerosolen.- 6.1 Histologische Begutachtung der Organteile.- 6.2 Ergänzende Beobachtungen zum Verhalten von Ratten unter der Aerosolinhalation.- Literatur.

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Book SynopsisOver the past two decades it has been increasingly recognized that whole-body ultrasound is an invaluable tool in the critically ill. In addition to offering rapid whole-body assessment, it has the advantage of being a bedside approach that is available at all times and can be repeated at will. Accordingly, it permits the immediate institution of appropriate therapeutic management. Whole-Body Ultrasound in the Critically Ill is the sequel to the author’s previous books on the subject, which were first published in French in 1992 and 2002 and in English in 2004. This new volume reflects the latest state of knowledge by including a variety of improvements, revised definitions, and updated algorithms. Findings in respect of individual organs are clearly presented, and a particular feature is the in-depth coverage of the lungs, traditionally regarded as an area unsuitable for ultrasound. Throughout, the emphasis is on the practical therapeutic impact of the technique. Its value in a variety of settings, including unexplained shock, management of hemodynamic instability, acute respiratory failure (the BLUE protocol), and the critically ill neonate, is carefully explained. Interventional ultrasound and less widely recognized applications, such as mesenteric infarction, pneumoperitoneum, and intracranial hypertension, are also described. Pitfalls of the technique receive due attention. Today, whole-body ultrasound touches upon every area of critical care. This book, from the chief pioneer in the field, shows that the technique enables critical care physicians to detect therapeutically relevant signs easily and quickly. It will serve as an invaluable guide to the practice of a form of visual medicine.Trade ReviewFrom the reviews:“Intensivists or radiologists with an interest in critical care applications of ultrasound are the intended audience for this work, edited by one of the fathers of critical care ultrasound. … This edition expands coverage of the abdomen and vascular system and increases the emphasis on the evaluation of deep venous thrombosis, pleural effusion, interstitial disease, and pneumothorax. … Chapters are written in a conversational style. … this remains an effective overview for intensivists.” (David J. Dries, Doody’s Review Service, December, 2010)Table of ContentsIntroductive Chapters.- Basic Notions of Critical Ultrasound.- The Ultrasound Equipment.- Specific Notions of Critical Ultrasound in the Critically Ill.- Organ by Organ Analysis.- to Abdominal Ultrasound: Normal Patterns.- Peritoneum.- Gastrointestinal Tract.- Liver.- Gallbladder.- Urinary Tract.- Various Targets in the Abdomen (Spleen, Adrenals, Pancreas, Lymph Nodes).- Aorta.- Principles of Examination of the Deep Veins in the Critically Ill.- Principles of Examination of the Deep Veins in the Critically Ill.- to Lung Ultrasound.- Pleural Effusion.- Lung: Alveolar Syndrome.- Lung and Interstitial Syndrome.- Pneumothorax.- Basic Applications of Lung Ultrasound in the Critically Ill: 1 – A Bedside Alternative to CT and Other Irradiating Techniques.- Basic Applications of Lung Ultrasound in the Critically Ill: 2 – The Ultrasound Approach of an Acute Respiratory Failure: The BLUE Protocol.- Applications of Lung Ultrasound in the Critically Ill: 3 – Lung Ultrasound in the Neonate.- Simple Emergency Cardiac Sonography.- Simple Critical Ultrasound Considering Hemodynamic Therapy: Our Limited Investigation.- Head and Neck.- Soft Tissues and Miscellaneous Areas.- Clinical Applications of Ultrasound.- Interventional Ultrasound.- Ultrasound in the Surgical Intensive Care Unit: Some Peculiarities.- Critical Ultrasound Outside the Intensive Care Unit.- Analytic Study of Severe and/or Frequent Situations in the Critically Ill.- Free Considerations.- A Way to Learn Critical Ultrasound.- Critical Ultrasound, Not Just a New Technique: Also a Philosophy.

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Book SynopsisEgal, ob Sie Weiterbildungsteilnehmer sind oder bereits erfahrene Fachpflegekraft in der Anästhesie und Intensivmedizin, mit diesem Arbeitsbuch können Sie Ihr Fachwissen gezielt überprüfen und festigen: Multiple-Choice-Fragen, Zuordnungsfragen und Abbildungen zum Beschriften helfen Ihnen dabei.Aus dem Inhalt: Physiologische und pathophysiologische Zusammenhänge, Wirkungen und Nebenwirkungen von Medikamenten, Dosierungen, Beatmung, Therapie und Symptome von intensivpflichtigen Krankheitsbildern, postoperative Versorgung nach schweren Operationen, Anzeichen von Komplikationen, Covid-19 und vieles mehr. Die ideale Ergänzung zu den großen Standardwerken der pflegerischen Fachweiterbildung wie z.B. "Larsens Anästhesie und Intensivmedizin für die Fachpflege". Die 4. Auflage ist komplett aktualisiert und um Fallbeispiele zu typischen Komplikationen in der Anästhesie und Intensivmedizin erweitert. Table of ContentsFragen.- Multiple Choice-Fragen.- Freitextantworten.- Zuordnungsaufgaben.- Abbildungen zum Beschriften.- Antworten.

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Book SynopsisAllgemeine Grundlagen.- Grundlagen der Hämodynamik.- Kardiale Hämodynamik.- Hämodynamisches Monitoring.- ECLS im kardiogenen Schock.- eCPR - ECLS in extremis.- V-A ECMO.- Erweiterte Konfigurationen und Unloading.- V-V ECMO.- Troubleshooting.- Allgemeine Aspekte ECLS/ECMO.- Beispielformulare.

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Book SynopsisTrade Review"As a preoperative/intraoperative/postoperative journey, the book is a nice overview for anesthesia providers and a reminder that our impact on patient outcomes is not just in the operating room, but also beyond it. It is much more in-depth on many topics than I anticipated and makes many references to studies and current research." -© Doody's Review Service, 2021, Nayema K Salimi, MD (Yale School of Medicine)Table of ContentsPART I: INTRODUCTION AND BACKGROUND 01. Implications of Perioperative Morbidity on Long-Term Outcomes, Lee A. Fleisher and Mark F. Newman 02. Ischemia and Ischemia-Reperfusion-Induced Organ Injury (Pathology), Mitchell P. Fink Henrik 03. The Inflammatory Response in Organ Injury, Benjamin Kohl and Clifford S. Deutschman 04. The Coagulation Cascade in Perioperative Organ Injury, M. S. Carraway and Claude Piantidosi 05. Analgesia, Fleisher 06. Fluid Management, Monty PART II: PREOPERATIVE ASSESSMENT 07. The Value of Preoperative Assessment, Stanlkey H. Rosenbaum and David G. Silverman 08. Cardiac Risk Assessment in Noncardiac Surgery, Edward Kwon, Lee A. Fleisher, and Kim Eagle 09. Cardiovascular Risk Assessment in Cardiac Surgery, Robert G. Johnson 10. Central Nervous System Risk Assessment, Katja Hindler and Nancy Nussmeier 11. Renal Risk Assessment, Christina Mora-Mangano,Charles C. Hill, and John L. Chow 12. Pulmonary Risk Assessment, Maurizio Cereda 13. Hematologic Risk Assessment, Carlos Marcucci, Pierre-Guy Chassot, Lars M. Asmis, and Donat R. Spahn PART III: PRESERVATION OF ORGAN FUNCTION AND PREVENTION AND MANAGEMENT OF PERIOPERATIVE ORGAN DYSFUNCTION CARDIOVASCULAR SYSTEM 14. Prevention of Ischemic Injury in Cardiac Surgery, Matthew Agnew, Christopher Salerno, and Edward D. Verrier 15. Prevention of Ischemic Injury in Noncardiac Surgery, Don Poldermans 16. Treatment of Perioperative Ischemia, Infarction, and Ventricular Failure in Cardiac Surgery, Brian Lima and Carmelo A. Milano 17. Perioperative Management of Valvular Heart Disease, Igor Izrailtyan and Joseph P. Mathew 18. Prevention and Management of Perioperative Dysrhythmias, Martin Slodzinski RENAL SYSTEM 19. Preservation of Renal Function, Mark Stafford-Smith 20. Treatment of Acute Oliguria, John A. Kellum 21. Perioperative Management of the Patient with Renal Failure, Per-Olof Jarnberg PULMONARY SYSTEM 22. Prevention and Treatment of Pulmonary Dysfunction, Christine A. Doyle, and Ronald G. Pearl CENTRAL NERVOUS SYSTEM 23. Carotid and Intracranial Surgery, Frederick W. Lombard,Michael L. James, John C. Keifer, David McDonagh, David Warner, and Cecil O. Borel 24. Protecting the Central Nervous System during Surgery, Hilary P. Grocott 25. Preservation of Spinal Cord Function, Michael M. McGarvey, Albert T. Cheung 26. Perioperative Management of Acute Central Nervous System Injury, W. Andrew Kofke GASTROINTESTINAL SYSTEM 27. Prevention and Treatment of Gastrointestinal MorbidityDuane Funk and Tong J. Gan HEMATOLOGY AND COAGULATION 28. Prevention and Management of Deep Vein Thrombosis and Pulmonary Embolism, Jagajan Karmacharya and Edward Y. Woo 29. Perioperative Management of Bleeding and Transfusion, Steven E. Hil and Richard C. D'Alonzo INFECTIONS 30. Prevention of Perioperative and Surgical Site Infection, Carlene A. Muto and Marian Pokrywska OBSTETRIC 31. Perioperative Protection of the Pregnant Woman, Theodore G. Cheek 32. Preservation of Fetal Viability in Noncardiac Surgery, Robert R. Gaiser and Mary K. McHugh PART IV: EARLY POSTOPERATIVE CARE SPECIFIC OPERATIONS 33. Cardiac Surgery, G. Burkhard Mackensen 34. General Thoracic Surgery, Todd W. Sarge and Alan Lisbon 35. Major Abdominal Surgery, Patrick J. Neligan and Jacob Gutsche 36. Major Orthopaedic Surgery, Babak Sarani, David T. Huang, and Robin West 37. Solid Organ Transplantation, David C. Kaufman and Carolyn E. Jones 38. Multisystem Trauma, Patrick K. Kim.and Patrick M. Reilly 39. Neurosurgery, Michael L. James and Cecil O. Borel SPECIFIC PROBLEMS 40. Sepsis and Septic Shock, Michael D. Malinzak and Laura E. Niklason 41. Acute Respiratory Failure, S. Rob Todd Gary A. Vercruysse,, and Frederick A. Moore 42. Endocrine and Electrolyte Disorders, Eugene W. Moretti, and Duane Funk 43. Pain, Delirium, and Anxiety, Winston C. V. Parris and Lesco Rogers PART V: CONFLICTING OUTCOMES 44. Economic Analysis of Perioperative Optimization, Tom Archer,Steve Mannis, and .Alex Maccario 45. Pay for Performance: An Incentive for Better Outcomes, Ronald A. Gabel NEW PALLIATIVE CARE IN THE ICU NEW PALLIATIVE CARE AT THE END OF LIFE

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Book SynopsisTrade Review"The editors have organized the text around a remarkable concept that five psychoses account for much of functional psychotic disorders. These five psychotic disorders have common causal factors that contribute to psychosis proneness. Three of these psychoses are already well recognized, and all five appear to be associated with a specific anxiety or depressive disorder. All this implies that neuroleptic treatment, when combined with properly specific anxiety and depression treatment, can make patients much better than with neuroleptics alone. Both editors have contributed to the supporting literature, but there is also a fascinating agenda for further research to explore and expand these concepts. When further documented by additional research, these diagnoses and treatments could have effects on psychotic disorder diagnosis and treatment that could be exceptional, if not ground-breaking. This is clearly a book that needs careful attention in a review, and a wide mental health audience." -- Ira D. Glick, M.D., Professor Emeritus of Psychiatry & Behavioral Sciences, Department of Psychiatry, Stanford University School of Medicine " Anxiety disorders have suffered relative neglect by psychiatry and psychopharmacology over the past several decades. Drs. Veras and Kahn have done the field a great service by putting together a volume that highlights the important overlap of these disorders, not just with mood disorders, but with schizophrenia spectrum illness as well. Psychotic Disorders will serve as a useful reminder of these under-appreciated comorbidities, in the service of more meaningful classification of psychoses and more effective treatment of those suffering from them." -- Edward Silberman, Professor of Psychiatry, Tufts University School of MedicineTable of Contents1. Introduction 2. Psychotogenesis Overview 3. Diagnosis: OCD/Schizo-Obsessive 4. Diagnosis: Panic/Panic Psychosis 5. Diagnosis: Social Anxiety/Delusional Disorder 6. Diagnosis: Melancholia/Delusional Depression 7. Diagnosis: Atypical Depression/Mania 8. Diagnosis: Substance Abuse Psychosis

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Book SynopsisTrade Review"This book provides essential insight into rapid intervention for emergencies in the ICU or urgent problems on the ward." ©Doody's Review Service, 2022, David James Dries, MD (University of Minnesota Medical School)

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Book SynopsisTrade Review"This book provides an encyclopedic approach to all aspects of perioperative safety, efficiency, quality, and quality improvement. It covers a wealth of topics, many of which are relevant to other aspects of surgical practice. Purchase of the paper copy includes access to an accompanying ebook, which is highly portable and fully searchable." ©Doody's Review Service, 2023, Carol Scott-Conner, MD, PhD, MBA (University of Iowa Hospitals and Clinics)Table of ContentsBackground section. What is quality in medicine and why do we need to work at it Where does safety fit in? What is perioperative medicine and why do we need it? The case for improvement in perioperative medicine The value of big data studies in perioperative medicine Clinical trials in perioperative medicine Large scale audits Education in perioperative medicine System thinking for perioperative medicine Patient centered care in perioperative medicine Shared decision making for surgery Publication for PM SQUIRE guidelines Section One: Improvement Science Tools for Change Process mapping Stakeholder engagement Creating urgency - techniques to make the case for change Theory of change Measurement for improvement Sampling Run charts Statistical Process Control Checklists Bundles Common improvement methodologies Background Lean Model for Improvement Six sigma and others DMAIC Others Driver Diagrams Social aspects of change Leadership skills Getting the message out (journalist / media expert) Communication for improvement Telling stories for improvement Human Factors and perioperative improvement Running a collaborative Section Two: Putting it all together - clinical quality improvement examples Michigan surgical collaborative - could have several different examples ERAS protocols Penn work Brain Health Initiative ELC and EPOCH PQIP Trainee initiatives UK Other US examples - particularly surgical.

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Book SynopsisTable of Contents1. The Segmental Approach to Congenital Heart Disease 2. Cardiovascular Physiology and Shock 3. Regulation of Pulmonary Vascular Resistance and Blood Flow 4. Renal Function and Heart Disease 5. Splanchnic Function and Heart Disease 6. Cerebral Function and Heart Disease 7. Pharmacology of Cardiovascular Drugs 8. Pediatric Arrhythmias 9. Pericardial Effusion and Tamponade 10. Anesthesia for Pediatric Cardiac Surgery 11. Applied Respiratory Physiology 12. Respiratory Support 13. Cardiac Arrest and Cardiopulmonary Resuscitation 14. Coagulation Disorders in Congenital Heart Disease 15. Nutrition 16. Transplantation 17. Noninvasive Diagnosis of Heart Disease 18. Diagnostic and Therapeutic Cardiac Catheterization 19. Perioperative Monitoring 20. Cardiopulmonary Bypass 21. Mechanical Circulatory Support in Infants and Children 22. Nursing Care 23. Perioperative Management of Patients with Congenital Heart Disease 24. ASD/VSD 25. Atrioventricular Septal Defects 26. Aortic Valve Disease 27. CoA and IAA 28. Mitral Valve Disease 29. AP Window/PDA 30. ACLA 31. Persistent Truncus Arteriosus 32. Total Anomalous Pulmonary Venous Return 33. Transposition of the Great Arteries and the Arterial Switch Operation 34. DORV/DOLV 35. TOF with PAT and VSD 36. Pulmonary Atresia with Intact Ventricular Septum (PA/IVS) 37. Ebstein's Anomaly 38. Single Ventricle 39. Tricuspid Atresia and the Fontan Operation 40. HLHS 41. Staged Operative Management of the SV 42. Critical Appraisal and Use of Evidence about Therapy 43. Cor Pulmonale 44. Inflammatory Heart Disease 45. Infective Endocarditis 46. Syndromes and Congenital Heart Defects 47. Heritable Disease 48. Cardiomyopathy

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Book SynopsisLiver Anesthesiology and Critical Care Medicine emphasizes all aspects of this broad and important area and is the definitive textbook for anybody involved in the perioperative care of liver patients. The book is divided into three sections: Physiology and Pathophysiology, Anesthesiology, and Critical Care Medicine. The anesthesiology section contains information about liver transplantation and other liver surgeries and provides detailed practical direction and concise background information of all aspects of the anesthetic management of these patients based on the most recent evidence. The critical care section describes basic critical care management as it relates to liver surgical patients and addresses specific postoperative issues relevant for liver resection and liver transplant patients. The book combines practical guidance to the perioperative management with exTrade ReviewFrom the reviews:“The definitive resource for anesthesiologists and critical care physicians who provide perioperative care for the patient with liver disease.” (Ravindea Alok Gupta, Anesthesiology, Vol. 121 (1), July, 2014)“This is a comprehensive review of every aspect of liver transplant anesthesiology and associated critical care medicine. … The book is directed at anesthesiology and critical care attending physicians who provide care to liver patients. It should serve as the major reference on liver transplantation for fellows training in liver transplant anesthesia or in critical care. … It should also be available in every major medical library as a resource for anyone with an interest in any aspect of this field.” (Michael F. O’Connor, Doody's Book Reviews, April, 2013)Table of ContentsLiver Anesthesiology and Critical Care MedicineSection I: Physiology, Pathophysiology and Pharmacology of Liver Disease1. Physiology and Anatomy of the LiverTeresa A. MulaikalJean C. Emond2. Acute hepatic failureAndrew SlackNavjoyt LadherJulia Wendon3. Drug Metabolism in Liver FailureSimon Lam4. Evaluation of Liver Disease D. Robert DufourNazia QaziSection II: Anesthesiology for Liver Transplantation5. History of Liver TransplantationJ. R. Klinck6. Recipient and Donor Selection and Transplant Logistics – The European PerspectiveGabriela A. BerlakovichGerd R. Silberhumer7. Recipient and Donor Selection and Transplant Logistics - The US PerspectiveIngo KleinClaus U. Niemann8. Surgical Techniques in Liver TransplantationJuan del rio Martin9. Intraoperative MonitoringClaus-Georg Krenn10. Liver TransplantationAnna WaliaRoman Schumann11. Caval Cross-clamping, Piggyback & Veno-venous BypassRuairi MouldingPaul Picton12. Liver Transplantation: Hemodynamic Changes, Cardiac Output Monitoring and Inotropic SupportAnand D. PadmakumarMark C. Bellamy 13. Coagulopathy: Pathophysiology, Evaluation, and TreatmentMatthew R. KappusArun J. Sanyal14. Physiology, Prevention, and Treatment of Blood Loss During Liver TransplantationFreeha ArshadTon LismanRobert J. Porte15. The Marginal Liver Donor and Organ Preservation StrategiesConey BaeScot D. HenryGiridhar VedulaJames V. Guarrera16. Pediatric Liver TransplantationPhilipp J. Houck17. Combined Solid Organ Transplantation Involving the LiverGeraldine Diaz18. Liver Transplantation for the Patient with High MELDCynthia WangRandolph Steadman19. Perioperative Considerations for Transplantation in Acute Liver FailureChristopher P. SnowdenDavid M. Cressey20. Renal FailureLloyd MeeksJoseph Meltzer21. The Patient With Severe Co-Morbidities: Cardiac DiseaseShahriar ShayanAndre M. De Wolf22. Pulmonary Complications of Liver DiseaseMercedes Susan MandellMasahiko Taniguchi23. Liver Transplantation: The Patient with Severe Co-morbidities, CNS Disease, and Increased Intracranial PressureChris WillarsGeorg AuzingerSection III: Anesthesiology for Liver Surgery24. Hepatobiliary Surgery: Indications, Evaluation, and OutcomesMilan KinkhabwalaMarcelo Vivanco 25. Liver Resection Surgery: Anesthetic Management, Monitoring, Fluids and ElectrolytesJean MantzCatherine Paugam-Burtz26. Anesthetic Aspects of Living Donor HepatectomyNavraj KahlonTricia Brentjens27. Complications of Liver SurgeryOliver PanzerJennifer Sandadi28. The Patient with Liver Disease for Non-Hepatic SurgeryKatherine PalmieriRobert N. Sladen Section IV: Critical Care Medicine for Liver transplantation29. Routine Postoperative Care After Liver TransplantationJonathan HastieVivek K. Moitra30. ImmunosuppressionAmit GeraKosh Agarwal31. Acute Kidney Injury after Liver TransplantationRaymond M. PlaninsicTetsuro SakaiIbtesam A. Hilmi 32. Early Graft FailureJames TrotterSrinath Chinnakotla 33. Sepsis and InfectionFuat Hakan Saner34. Respiratory Failure and ARDSJames Y. FindlayMark T. Keegan 35. Pain Management in Liver TransplantationPaul WeykerChristopher WebbLeena Mathew Section V: Critical care Medicine for Liver surgery36. Post Operative Care Of Living Donor for Liver TransplantSubramanian SathishkumarTadahiro Uemura37. Liver Surgery – Early Complications: Liver Failure, Bile Leak and Sepsis Albert C.Y. ChanSheung Tat Fan

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Book SynopsisThe aim of this book is to identify and shed new light on the main surgical practices involved in acute care and trauma surgery. Adopting an evidence-based approach, a multidisciplinary team of surgeons and intensivists illustrate basic and advanced operative techniques, accompanied by a comprehensive and updated reference collection. Emerging surgical procedures in Acute Care Surgery are also explored step by step with the help of ample illustrations. Further, the book offers an overview of treatment options for acute organ failure, with a focus on peculiar clinical situations that call for special treatment, including: extracorporeal membrane oxygenation (ECMO), circulatory support and urgent liver transplantation. In order to identify the key determinants in decision-making and therapeutic support that can help avoid critical errors, authors not only define and discuss specific surgical techniques, but also present major issues and controversies related to it. In essence, the book can be considered a “What to do guide” that offers easy access to both basic and advanced lifesaving surgical procedures, due in part to text boxes highlighting “Tips, Tricks and Pitfalls” as well as advice on “Complications Management”. Many chapters are enriched by providing clinical case scenarios, an important educational resource including self–assessment questionnaires.Trade Review“Senior trainees and providers are an appropriate audience. … This book is an effective combination of the evolution in European thinking with considered inclusion of the North American approach to trauma care. The scope is expansive and reference lists feature major contributions from both North America and Europe. … this book adequately presents the growing number of techniques and treatment strategies available to acute care surgeons.” (David J. Dries, Doody's Book Reviews, August 09, 2019)Table of ContentsForeword.- Preface.- I General Principles.- 1 Surgical training for surgery and emergency surgery.- 2 Pathophysiology of acute illness and injury.- 3.- Shock states in acute care surgery.- 4 Pre-operative risk assessment.- 5 New advances in sepsis management.- II Trauma.- 6 Critical care resuscitation in trauma patients: basic principles and evolving frontiers.- 7 Airway management.- 8 Essential and basic operative techniques in trauma injuries.- 9 Modern management of maxillofacial injuries.- 10 Modern management of ophthalmic injuries.- 11 New advances in traumatic brain injuries.- 12 Operative techniques in blunt and penetrating neck injury.- 13 Operative techniques in spinal column and spinal cord injury.- 14 Operative technique in pelvic fractures.- 15 Chest wall and diaphragmatic injuries.- 16 Pleural, lung and tracheal injuries.- 17.- Vascular Injuries of the neck.- 18 Blunt trauma of the heart.- 19 Blunt trauma of the great vessels.- 20 Penetrating trauma of the heart and great vessels.- 21 Damage control and open abdomen in abdominal injury.- 22.- Operative techniques in abdominal injury.- 23.- Operative techniques in genitourinary trauma.- 24 Operative techniques in vascular injuries of the extremities.- III Non traumatic Emergency Surgery.- 25 Updates in diagnosis and management of acute gastrointestinal haemorrhage.- 26 Updates in the management of the inflammatory conditions and obstructions of the GI tract.- 27 Updates in the management of acute pancreatitis.- 28 Updates in the management of cholecystitis and cholangitis and obstructive jaundice.- 29 Updates in the management of Ob-Gyn emergencies.- 30 Updates in the management of non-traumatic thoracic and thoraco-abdominal vascular emergencies.- 31 Updates in the management of non-traumatic abdominal vascular emergencies.- 32 Updates in the management myocardial revascularization emergencies.- 33 Updates in the management heart valve emergencies.- 34 Updates in the management oesophageal emergencies.- 35 Updates in the management of GI tract foreign bodies.- 36 Updates in the management of anorectal abscess and inflammatory process.- 37 Updates in the management of abdominal wall hernias emergencies and reconstruction.- 38 Updates in the management of necrotizing soft tissue infections (NSTI).- IV Surgical critical care and special topics.- 39 Compartment syndrome.- 40 Invasive and non-invasive hemodynamic monitoring.- 41 Bedside US diagnosis and monitoring in ICU.- 42 Scoring Systems for Organ Injury.- 43 Multiple organ dysfunction syndrome.- 44 Updates in acute respiratory dysfunction: mechanical ventilator and ECMO support.- 45 Cardiovascular failure and mechanical circulatory support (LVAD).- 46 ECMO as a mechanical circulatory support.- 47 Acute liver failure and hyper-urgent liver transplantation.- 48 The potential organ donor.

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Book SynopsisDie parenterale Ernährung hat in den letzten 15 Jahren eine stürmische Entwicklung durchgemacht und muß heute als fester Bestandteil der therapeutischen Medizin an­ gesehen werden. Ausreichende Kenntnisse über die technischen Möglichkeiten dieser Therapie, die Auswirkungen ihrer einzelnen Bausteine auf den Stoffwechsel des Kran­ ken sowie ihre Risiken sollten zum Rüstzeug jedes klinisch tätigen Arztes gehören. Es kann heute keine Entschuldigung mehr dafür geben, daß der Nahrungsbedarf eines Kranken ungedeckt bleibt, nur weil er nicht mehr in der Lage ist, oral genügend Nah­ rung aufzunehmen. Die Standardinfusionstherapie, üblicherweise bestehend aus 2 bis 3 Liter Elek­ trolyt-Aminosäuren- oder niedrigprozentigen Kohlenhydratlösungen unterscheidet sich von der hochkalorischen parenteralen Ernährung vor allem durch die Osmolarität des Infusionsgemisches und dem Zugangsweg. Bei der Standardtherapie ist der peri­ phere Zugang die Regel und ein Verlust an Struktur- oder Funktionsproteinen wird bewußt in Kauf genommen, da eine ausreichende Energiezufuhr zur Verstoffwechse­ lung der zugeführten Aminosäuren nicht möglich ist, ohne Schäden an der Venen­ wand hervorzurufen. Durch die hochkalorische parenterale Ernährung werden, wobei der zentrale Venenkatheter eine Grundvoraussetzung ist, dem Kranken hochprozen­ tige Kohlenhydratlösungen, Fette und Aminosäuren in einer Größenordnung verab­ reicht, die nicht nur seinen aktuellen Bedarf decken, sondern auch vorbestehende Mangelzustände ausgleichen können. Die Kathetertechnik und die Entwicklung der Infusionslösungen befindet sich auf einem so hohen Stand, daß eine parenterale Versorgung des Organismus mit Nährstoffen auch über Monate hinweg möglich ist. Besondere Beobachtungen erfuhr in der letzten Zeit die Anwendung der hoch­ kalorischen parenteralen Ernährung bei den entzündlichen Darmerkrankungen und in der Onkologie.Table of ContentsGrundlagen der hochkalorischen parenteralen Ernährung.- Meßgrößen zur Definition des Ernährungszustandes als Voraussetzung einer Ernährungstherapie.- Zur Frage der Wertigkeit der Erhebung des Ernährungszustandes bei Malignompatienten.- Technik und Komplikationen des zentralen Venenkatheters zur hochkalorischen parenteralen Ernährung.- Sicherung des Proteinbestandes als Voraussetzung einer effizienten Ernährungstherapie.- Aminosäuren- und Eiweißstoffwechsel bei beatmeten Polytraumatisierten unter hochkalorischer parenteraler Ernährung.- Stickstoffbilanz und Serumaminosäurenkonzentration bei polytraumatisierten Patienten unter totaler parenteraler Ernährung und Zufuhr von Wachstumshormon.- Das Verhalten der freien Plasmaaminosäuren während langfristiger totaler parenteraler Ernährung.- Umsatzkapazitäten und Nebenwirkungen von Zuckern und Polyolen bei parenteraler Applikation.- Der postoperative Stoffwechsel — Unterschiede bei prä- und postoperativem Beginn der totalen parenteralen Ernährung.- Funktion und Stellenwert von Neutralfett in der Ernährungstherapie.- Vergleich von Stoffwechselwirkungen bei zwei verschiedenen Fettemulsionen während parenteraler Zufuhr.- Parenterale Ernährung bei entzündlichen Darmerkrankungen.- Totale parenterale Ernährung bei der Behandlung chronisch entzündlicher Darmerkrankungen.- Hochkalorische parenterale Ernährung als Operationsvorbereitung bei Colitis ulcerosa und Ileocolitis granulomatosa Crohn.- Totale parenterale Ernährung als Primärtherapie des Morbus Crohn.- Parenterale oder elementar-orale Ernährung bei kompliziertem Morbus Crohn? Eine prospektive Untersuchung.- Anwendung der hochkalorischen parenteralen Ernährung in der Onkologie.- Aspekte des Tumorstoffwechsels für die parenterale Ernährung.- Hochkalorische parenterale Ernährung in der Onkologie — Tierexperimentelle Ergebnisse.- Hyperalimentation bei Krebspatienten.- Der Einfluß der präoperativen hochkalorischen parenteralen Ernährung auf die postoperative Komplikationsrate in der Tumorchirurgie.- Beeinflussung der Immunitätslage bei Tumorpatienten durch hochkalorische parenterale Ernährung.- Präoperative hochkalorische parenterale Ernährung bei Tumorpatienten.- Ambulante parenterale Ernährung bei Tumorpatienten.- Hochkalorische parenterale Ernährung in der onkologischen Radiotherapie.- Hämopoetische Regeneration nach aggressiver Chemotherapie mit und ohne parenterale Ernährung.- Parenterale Ernährung bei der kombinierten Chemo- und Strahlentherapie des metastasierenden Ovarialkarzinoms.- Parenterale Ernährung kachektischer Patienten regeneriert die durch Mangelernährung supprimierte Hämatopoese.- Perioperative Veränderungen von Aminosäuren und anderen biochemischen Parametern bei Karzinompatienten — eine vorläufige Mitteilung.- Plasmaaminosäurenspiegel bei malignen Tumoren des Gastrointestinaltrakts.- Veränderungen der Plasmaaminosäuren bei progressiven Karzinomen.- Untersuchungen zum Vitaminversorgungsgrad von Patienten mit malignen Tumoren.

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Book SynopsisThe continued high mortality (up to 70 %) in patients with necro- tizing pancreatitis and diffuse peritonitis has led to the develop- ment of various surgical strategies within the past few decades. Up to the present decisions about the management of these disea- ses have been rather difficult because of the individual courses differ considerably, even being incomparable. Today, as a result of our in creased knowledge of the pathophysiology, the impro- ved imaging procedures, and the standaridized intensive care, the rend is moving toward delayed surgical intervention. The goals in the surgical treatment of necrotizing pancreatitis and diffuse peritonitis are still surgical removal of the focus of infection, elimination of endotoxins by lavage, and optimal drainage of the peritoneal cavity. Depending on the patient's general condition this cannot always be achieved in the first surgi- cal intervention. A number of surgical methods have therefore been developed, such as postoperative dorsoventral lavage, step- by-step lavage therapy, postoperative closed continuous perito- neal lavage, and open treatment (laparostomy). The last-mentioned method ist not new; it was first described by KOR'J;E in 1894 for the treatment of necrotizing pancreatitis. However, due to the progress in intensive care medicine (long- term respiratory therapy, hemofiltration, etc.) in the last few years this method of management has become successful and gai- ned in recognition.Table of ContentsI. Abdominal Sepsis.- 1. Pathology.- Pathology of Sepsis and Its Effects on the Pancreas.- Effects of Sepsis on the Lung.- Effects of Sepsis on the Liver.- Hygienic Management Following Laparostomy.- 2. Treatment.- Treatment of Respiratory Disorders.- Peritonitis and Intraabdominal Abscesses.- Parenteral and Enteral Nutrition in Sepsis.- New Concepts in Fluid Therapy for Patients with Intraabdominal Infection.- Pancreatitis and Blood Coagulation.- The Effect of Norepinephrine on Hemodynamics in Extreme High Output — Low Resistance State in Peritonitis and Pancreatitis.- Endotoxemia Fails to Predict Survival in Severe Intraabdominal Infection.- II. Pancreatitis.- 1. Open Packing.- The Role of Open Packing in the Management of Infected Pancreatic Necrosis.- Interdisciplinary Management in Necrotizing Pancreatitis.- Laparostomies and Preplanned Revisions: A Therapeutic Concept in Acute Necrotizing Pancreatitis.- The Extraperitoneal Compartment — Surgical Approach to Necrotizing Pancreatitis.- Benefit and Limitations of Open Packing Laparostomy in Acute Pancreatitis.- Surgical Therapy of Necrotizing Pancreatitis by Open Packing Laparostomy.- Value of Open Packing in the Treatment of Necrotizing Pancreatitis.- Total Necrosis of the Pancreas with Peripancreatic Necrosis — An absolute Indication for Laparostomy?.- 2. Alternative Procedures.- Acute Necrotizing Pancreatitis: Surgical Management with Capillary Drainage, Long-term Lavage and Continuous Enteral Nutrition.- Necrosectomy and Continuous Closed Bursa Lavage in Necrotizing Pancreatitis.- Surgery During Acute Pancreatitis — Observations in 289 Patients.- Routine Repetitive Laparotomy for Acute Necrotizing Pancreatitis.- III. Peritonitis.- 1. Open Packing.- Step-by-Step Lavage Therapy for Diffuse Peritonitis: a Clinical Report.- Intensive Therapy in the Surgical Treatment of Diffuse Peritonitis.- Open Treatment in Diffuse Suppurating Peritonitis.- Laparostomy for the Surgical Treatment of Diffuse Peritonitis.- Open Management of the Septic Abdomen Using the Plastic Bag Technique.- Open Packing in the Treatment of Perforated Sigmoid Diverticulitis.- Complications of Laparostomy in Diffuse Peritonitis.- Pitfalls and Errors in Open Packing Laparostomy.- Dressing Laparostomies with Synthetic Mesh.- 2. Alternative Procedures.- Closed Continuous Postoperative Peritoneal Lavage in Diffuse Bacterial Peritonitis.- Severe Postoperative Peritonitis: Management with One-Stage Operation and Primary Closure of the Abdomen.- Management of the Organisms and Resistance Development with Diffuse Peritonitis During Programmed Open Lavage.- Effect of the Frequency of Programmed Peritoneal Lavage on Chances of Survival with Diffuse Peritonitis.- Planned Relaparotomy in Severe Diffuse Peritonitis.

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Book SynopsisKlar strukturiert, verständlich geschrieben und einprägsam bebildert, vermittelt der Band Grundlagen und Praxis der Beatmung: von der Physiologie der Atmung, Formen der respiratorischen Insuffizienz, Indikationen und Kontraindikationen bis zu modernen Beatmungsverfahren. Alle Informationen sind so ausführlich wie nötig und so stringent wie möglich dargestellt, so dass Ärzte und Pflegende rasch Antworten auf klinische Fragestellungen finden. Für die 5. Auflage wurden alle Kapitel überarbeitet und um Fragen zur Überprüfung des Fachwissens ergänzt.Table of Contents1 Anatomie der Atmungsorgane.- 2. Physiologie der Atmung.- 3. Blutgase.- 4. Säure-Basen-Haushalt.- 5. Respiratorische Insuffizienz .- 6. Endotracheale Intubation.- 7. Tracheotomie.- 8. Fiberoptische Bronchoskopie.- 9. Atemgaskonditionierung, physikalische Therapie und Lagerungstherapie.- 10. Analgesie, Sedierung und Muskelrelaxierung.- 11. Thoraxdrainagen.- 12 Beginn der Beatmung.- 13. Nichtinvasive Atemhilfen und nichtinvasive Beatmung (NIV).- 14. Beatmungsformen: Übersicht.- 15. Einstellgrößen am Beatmungsgerät.- 16. Klassische Beatmungsverfahren.- 17. Spezielle Beatmungsverfahren.- 18. Extrakorporale Lungenunterstützung.- 19. Überwachung der Beatmung.- 20. Auswirkungen und Komplikationen der Beatmung.- 21. Entwöhnung von der Beatmung (Weaning).- 22. Intra- und postoperative Beatmung.- 23. Intraoperative Beatmung von Kindern.- 24. Transport des beatmeten Patienten.- 25. Akutes Lungenversagen (ARDS).- 26. Respiratorische Viruserkrankungen.- 27.- Akute respiratorische Insuffizienz bei chronisch-obstruktiver Lungenerkrankung (COPD).- 28. Status asthmaticus.- 29. Beatmung beim Thoraxtrauma.- 30. Beatmung bei Schädel-Hirn-Trauma und erhöhtem intrakraniellem Druck.- 31. Beatmung am Lebensende.- 32. Beatmung bei Kapazitätsengpässen.- Stichwortverzeichnis.

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Book SynopsisOver the past two decades, electrophysiology has undergone unprecedented changes thanks to technical improvements, which simplify measurement and analysis and allow more compact data storage. This book covers in detail the spectrum of electrophysiology applications in patients with disorders of consciousness. Its content spans from clinical aspects of the management of subjects in the intensive care unit, including EEG, evoked potentials and related implications in terms of prognosis and patient management to research applications in subjects with ongoing consciousness impairment. While the first section provides up-to-date information for the interested clinician, the second part highlights the latest developments in this exciting field. The book comprehensively combines clinical and research information related to neurophysiology in disorder-of- consciousness patients, making it an easily accessible reference for neuro-ICU specialists, epileptologists and clinical neurophysiologists as well as researchers utilizing EEG and event-related potentials.Trade Review“This book takes an in-depth look at neurophysiologic modalities that may be used in the assessment of disorders of consciousness. … This book is concise and easily interpretable and will appeal to clinicians that care for patients with disorders of consciousness in the acute and chronic states. … Each chapter is well cited, with appropriate use of older and newer references. … This book should serve for a reference guide for any clinician caring for patients with disorders of consciousness.” (Amy Z. Crepeau, Journal of Clinical Neurophysiology, Vol. 32 (6), December, 2015)“This is a review of electroencephalography and evoked potentials in both critical care and subacute settings. … New providers treating patients with neurological illnesses and senior practitioners who wish to have a concise monograph to review recent developments in clinical neurophysiology will find this book a worthy introduction. … This is an excellent primer for the important horizon of neurological monitoring and prognostication.” (David J. Dries, Doody's Book Reviews, May, 2015)Table of Contents1. The acute clinical setting.- 2. Electroencephalography (EEG) and evoked potentials (EP): technical background.- 3. Which EEG patterns deserve treatment in the ICU?.- 4. EEG in refractory status epilepticus.- 5. Prognostic use of EEG in acute consciousness impairment.- 6. Prognostic use of somatosensory EP in acute consciousness impairment (including drug effects).- 7. Prognostic use of cognitive EP in acute consciousness impairment.- 8. The chronic clinical setting.- 9. Correlations of JHD EEG with consciousness recovery.- 10. Correlations of HD EP with consciousness recovery.- 11. Disorders of consciousness and sleep.- EEG-TMS.- 13. Outlook: imaging correlations.

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Book SynopsisDuring the last 20 years two groups of investigators have concerned themselves with the problem of acid-base regulation at various body temperatures. Each group, in professional isolation, pursued a separate path. Surgeons and anesthe­ tists developed techniques and tools for hypothermic cardio-pulmonary by-pass operations and based their rationale for acid-base management on in vitro models of blood behavior. Physiologists and biochemists, on the other hand, endeavored to understand acid-base regulation in living organisms naturally subjected to changes in body temperature. Only in the last decade has there been an increasing awareness that each group could benefit from the other's experiences. With this goal in mind members of both groups were invited to present their views and observations in the hope of arriving at a better understanding of acid-base management during hypothermia and gaining a greater insight into the factors which control acid-base regulation during normothermia. This led to the presen­ tation of the present volume with the aim of providing the clinician with a survey of present theories and the resulting strategies for management of the hypother­ mic patient. Acknowledgment The editors express their great appreciation to Miss Augusta Dustan for her dedicated effort in the preparation and editing of the manuscripts. Contributors Heinz Becker, M. D. Department of Surgery, University of California Medical Center, Los An­ geles, Los Angeles, CA 90024, U. S. A. Gerald D. Buckberg, M. D. Department of Surgery, University of California Medical Center, Los An­ geles, CA 90024, U. S. A.Table of ContentsGeneral Concepts.- 1. Introduction.- 2. What are normal acid-base conditions in man when body temperature changes?.- 3. Acid-base regulation during hibernation.- 4. Enzymatic consequences under alphastat regulation.- Clinical Applications.- 5. Acid-base management during hypothermic circulatory arrest for cardiac surgery.- 6. Hypothermia and acid-base regulation in infants.- 7. Myocardial function resulting from varying acid-base management during and following deep surface and perfusion hypothermia and circulatory arrest.

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Book SynopsisThis book provides health professionals with sound clinical advice on management of the obese patient admitted into hospital. It addresses all aspects of the patient's care, as well as serving as a resource to facilitate the management of services, use of clinical information, and negotiation of ethical issues that occur in intensive care.Trade Review“Critical Care Management of the Obese Patientdoes indeed provide a very useful reference for anybody who is involved in managing critically ill patients because, as time goes on, more and more of these patients are likely to be obese.” (Diabetes Update, 1 October 2013)Table of ContentsList of Contributors, viii Preface, xiii Part I Physiology and Consequences of Obesity 1 Cardiovascular Physiology in Obesity, 3 Eric J. Chan and Martin A. Alpert 2 Effects of Obesity on Respiratory Physiology, 13 Philippe Abou Jaoude, Jahan Porhomayon, and Ali A. El Solh 3 Gastrointestinal Physiology in Obesity, 21 Alexander D. Miras and Carel W. le Roux 4 Metabolic and Endocrine Physiology in Obesity, 28 Paula Alvarez-Castro, Susana Sangiao-Alvarellos, and Fernando Cordido 5 Renal Physiology in the Critically Ill Obese Patient, 38 Eric A.J. Hoste and Jan J. De Waele Part II Positive Pressure Ventilation 6 Sedation, Paralysis, and Pain Management of the Critically Ill Obese Patient, 47 Christopher G. Hughes, Lisa Weavind, and Pratik P. Pandharipande 7 Upper Airway Management in the Morbidly Obese Patient, 58 Michael Tielborg and Anthony Passannante 8 Mechanical Ventilation of the Obese Patient, 67 Mohammed Mogri and M. Jeffery Mador 9 Management of Acute Lung Injury in the Obese Patient, 74 Hallie C. Prescott and James M. O’Brien Jr Part III Management of Obesity Complications in Critical Care 10 Management of Infectious Complications in the Critically Ill Obese Patient, 85 Kristin Turza Campbell, Laura H. Rosenberger, Amani D. Politano, Tjasa Hranjec, and Robert G. Sawyer 11 Management of Gastrointestinal Complications in the Critically Ill Obese Patient, 93 Benjamin H. Levy III and David A. Johnson 12 Management of Endocrine Complications in the Critically Ill Obese Patient, 102 Joseph Varon and Ilse M. Espina 13 Management of Venous Thromboembolism in the Critically Ill Obese Patient, 108 Terence K. Trow and Richard A. Matthay 14 Nursing Care of the Critically Ill Obese Patient, 116 Margaret E. McAtee Part IV Hemodynamic Monitoring and Radiological Investigations 15 Hemodynamic Monitoring of the Critically Ill Obese Patient, 125 Wim K. Lagrand, Eline R. van Slobbe-Bijlsma, and Marcus J. Schultz 16 Diagnostic Imaging of the Critically Ill Obese Patient, 135 Venkata S. Katabathina, Neeraj Lalwani, Carlos S. Restrepo, and Srinivasa R. Prasad Part V Postsurgical Management 17 Postoperative Care of the Obese Patient, 149 Hui Sen Chong and Robert L. Bell 18 Management of the Obese Patient with Trauma, 159 Hadley K. Herbert and Therèse M. Duane 19 Abdominal Solid Organ Transplantation in the Obese Patient, 169 Erin C. Hall and Dorry L. Segev 20 Critical Care Management of the Obese Patient after Bariatric Surgery, 179 Scott E. Mimms and Samer G. Mattar 21 Nutritional Requirements of the Critically Ill Obese Patient, 186 Bikram S. Bal, Frederick C. Finelli, and Timothy R. Koch Part VI Pharmacology 22 Drug Dosing in the Critically Ill Obese Patient, 197 Brian L. Erstad Part VII Prognosis and Ethics 23 Prognosis and Outcome of the Critically Ill Obese Patient, 211 Yasser Sakr, Mohamed Zeiden, and Juliana Marques 24 Ethical Considerations in the Critically Ill Obese Patient, 218 Mark D. Siegel Multiple Choice Questions, 225 Answers to Multiple Choice Questions, 234 Index, 236

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Book SynopsisOffers an account of life in the Intensive Care Unit (ICU) of a major inner-city hospital, San Francisco. This book presents the stories of patients who show up with myriad disorders: asthma, cardiac failure, gastrointestinal diseases, complications due to AIDS, the effects of drug and alcohol abuse, and, emphysema.Trade Review"[Intensive Care] faces the raw edge of urban living. It is in the daily detail of an ICU at work that Murray wonderfully depicts a place of function and dysfunction. Murray shows that the ICU is a place of small successes rather than triumphant victories."-Richard Horton, New York Review of Books; "Dr. Murray is an evenhanded guide to the real world of intensive care medicine. His book is informative, a necessary counterweight to the medical fiction of popular entertainment. It may not be something to read for entertainment, but it is important to read if we are to know what crisis medicine can and cannot do for us."-San Francisco Chronicle Book Review; "Takes the reader on his daily rounds at the intensive care unit (ICU) of the San Francisco General Hospital. Between realistic scenes of bedside medical diagnoses and analyses, we also encounter the ethical dilemmas confronting today's medical establishment and society. Recommended for its naturalistic picture of inner-city hospital medicine."-James Swanton, Library Journal

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Book SynopsisThe definitive treatment on the medical evacuation and management of injured patients in both peace- and wartime. Edited by eminent experts in the field, this text brings together medical specialists from all four branches of the armed services. It discusses the history of aeromedical evacuation, triage and staging of the injured patient, evacuation from site of injury to medical facility, air-frame capabilities, medical capabilities in-flight, response to in-flight emergencies, and mass emergency evacuation. Specific medical conditions are addressed in detail, including such general surgical casualties as abdominal wounds and soft tissue, vascular, maxillofacial, head and spinal cord injuries, ophthalmologic, orthopaedic, pediatric, obstetric-gynecologic casualties, burns, and more. Over 80 illustrations provide a review of transport equipment and both medical and surgical treatment. A must-have reference for all armed forced physicians and flight surgeons, for general and trauma surgeons, internists, intensive care specialists, orthopaedic surgeons, and public health service physicians.Table of ContentsIntroduction.- Aeromedical Evacuation: A Historical Perspective.- Military Casualty Evacuation: MEDEVAC.- Civilian Air Medical Transport.- Aircraft Considerations for Aeromedical Evacuation.- Preparation for Long-Distance Aeromedical Evacuation.- Aeromedical Patient Staging.- Military Aeromedical Evacuation Nursing.- Critical-Care Air Transport: Patient Flight Physiology and Organizational Considerations.- Aeromedical Evacuation of Patients with Abdominal, Genitourinary, and Soft Tissue Injuries.- Orthopedic Patients.- Aeromedical Evacuation of the Neurosurgical Patient.- Otorhinolaryngology Head and Neck Surgery Patients.- Care of Ophthalmic Casualties.- Peripheral Vascular Casualties.- Aeromedical Evacuation of Cardiothoracic Casualties.- Burn Casualties.- Patients Requiring Mechanical Ventilation.- Medical Casualties.- Aeromedical Evacuation of Patients with Contagious Infections.- Aeromedical Evacuation of Obstetric and Gynecological Patients.- Overview of Pediatric and Neonatal Transport.- Aeromedical Evacuation of Psychiatric Casualties.

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Book SynopsisThis comprehensive third edition provides robust support to clinicians providing perioperative care for patients. Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This book offers evidence and experience-based information, advice, and guidelines on all aspects of perioperative medicine. Care around surgeries in many major clinical areas are included, including cardiology, pulmonology, gastroenterology, rheumatology, endocrinology, and so on. This new edition has been updated throughout with the latest literature, more visual content (tables and algorithms), and eleven new chapters on topics such as: chronic pain, congestive heart failure, hormone therapy and transgender patients, and postoperative hypoxemia. This new edition focuses on high value care in order to improve outcomes, including minimizing complications and readmissions. It also provides streamlined key points for caring for patients with medical diagnoses that may be especially complicated around surgery. This resource is invaluable for practicing physicians (including medical consultants, surgeons, and anesthesiologists) and other professionals who aim to optimize care of surgical patients.Trade ReviewTable of ContentsIntroduction.- The Preoperative Evaluation.- Perioperative Medication Management.- Anesthesia Fundamentals.- Cardiovascular Risk Stratification.- Ischemic Heart Disease.- Congestive Heart Failure.- Atrial Fibrillation.- Hypertension.- Valvular Heart Disease.- Implantable Cardiac Devices.- Diabetes.- Stress Dose Steroids.- Thyroid Disease.- Hormone Therapy and Transgender Patients.- Liver Disease.- Inflammatory Bowel Disease.- Chronic Anticoagulation.- Disorders of Hemostasis.- Thrombophilias.- Thrombocytopenia.- Anemia.- Sickle Cell Disease.- Venous Thromboembolic Disease.- Cerebrovascular Disease.- Epilepsy and Seizure Disorders.- Parkinson’s Disease.- Spinal Cord Injury.- Chronic Pain.- Pulmonary Risk Assessment and Management.- Asthma and COPD.- Obstructive Sleep Apnea / Obesity Hypoventilation Syndrome.- Pulmonary Hypertension.- Special Topics in Lung Disease: Restrictive, Myesthenia Gravis.- Chronic Kidney Disease.- Acute Kidney Injury.- Rheumatoid Arthritis.- Systemic Lupus Erythematosus.- Gout and Pseudogout.- Decision-Making Capacity.- Elderly Patients and Frailty.- Nutrition.- Patients with Solid Organ Transplant.- Substance Use and Dependence.- Postoperative Evaluation and Care.- Postoperative Fever.- Postoperative Delirium.- Postoperative Ileus.- Postoperative Hypoxemia.- Postoperative Tachycardia.- Postoperative Emergencies.- Postoperative Electrolyte Abnormalities.- Acute Pain Management Pearls.- Surgical Procedures Overview.

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Book SynopsisThis extensively revised new edition comprehensively reviews the medical and surgical management of the acutely-ill child with congenital and acquired cardiac disease. It enables the reader to gain a thorough understanding of basic and practical concepts of anatomy, pathophysiology, surgical techniques and peri-operative management in this group of patients. Extensively revised chapters cover the management of cardiac patients on extracorporeal membrane oxygenation, hemofiltration, and plasma exchange. New topics covered include the use of pharmaceuticals in cardiac intensive care, the implications of interventional cardiology in pediatric intensive care and ventricular assist devices. Practically relevant guidelines are also included for cardiovascular nurses. Critical Care of Children with Heart Disease presents a thorough review of the practical concepts, available treatment techniques, and the challenges associated with managing these patients in the critical care unit. It represents a timely and valuable textbook reference for students and practising healthcare professionals alike seeking to learn or further their understanding of the latest advances in this discipline. Trade Review“Thanks for the reader-friendly design, featuring an abundance of illustrations, photographs, tables as well as information boxes, the book enables the readers to visually grasp and retain difficult concepts. … This extensively revised new edition … comprehensively reviews the medical and surgical management of the acutely-ill child with congenital and acquired cardiac disease. We recommend!” (Richard Eyermann, Zeitschrift Deutsches Zentrum für herzkranke Kinder, Vol. 23 (2), 2021)Table of ContentsTransition from the fetal to the neonatal circulation.- Triage and Transport of Infants and Children with Cardiac Disease.- Airway control, mechanical ventilation and respiratory care.- Heart-Lung Interactions.- Cardiac Catheterization.- Echocardiography.- Cardiac Anesthesia.- A Pharmacokinetic and Pharmacodynamic review: focus on cardiac ICU meds.- Sedation and Analgesia.- Drugs in Cardiac Intensive Care.- Standard Drug Concentrations in the Cardiac Intensive Care unit.- Monitoring of the cardiac patient.- The effects of cardioplumonary bypass following pediatric cardiac surgery.- Nursing care of the pediatric cardiac patient.- Intensive Care for the Patient after Cardiac Catheterization.- Cardiac database and risk factor assessment outcomes analysis of congenital heart disease.- Patent ductus arteriosus.- Atrial Septal Defects.- Ventricular Septal defect.- Complete Atrioventricular Septal Defects.- Aortopulmonary Window.- Tetrology of Fallot.- Tetralogy of Fallot with absent pulmonary valve.- Tetralogy of Fallot with pulmonary atresia.- Pulmonary atresia with intact interventricular septum.- Pulmonary Stenosis.- Left Ventricular Outflow tract obstruction.- Coarctation of the Aorta.- Interrupted aortic arch.- Mitral Valve anomalies and related disorders.- Mitral Stenosis.- Prosthetic Valves.- Hypoplastic Left Heart Syndrome.- Single Ventricle, General Aspects.- Anomalous pulmonary veins.- Dextro-Transposition of the Great Arteries.- Congenitally corrected transposition of the Great Arteries (ccTGA or Levo-Transposition of the Great Arteries (l-TGA).- Truncus Arteriosus.- Double Outlet Right Ventricle.- Ebstein's Disease.- Anomalous Coronary Arteries.- Aortic Valve Regurgitation.- Vascular Rings and Pulmonary Sling.- Takaysu Arteritis.- Aortic Dissection.- Tracheal Reconstruction.- Acute Pulmonary Hypertension.- Chronic Pulmonary Hypertension.- Acute Myocarditis and cardiomyopathies.- Pericardial Diseases.- Infective Endocarditis.- Cardiac Failure.- Shock in the Cardiac Patient: A brief overview.- Mechanical circulatory support in pediatric cardiac surgery.- Ventricular Assist Devices.- Heart Transplantation.- Arrhythmias in the Intensive Care unit.- Pacemakers (temporary and permanent), Implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy.- Quality Assessment in the Cardiac Intensive Care unit.- Discontinuation of Life: Ethical and Legal issues.- Respiratory complications: acute respiratory distress syndrome, chylothorax, diaphragmatic palsy, and functional respiratory physiotherapy.- Gastrointestinal Complications: Necrotizing Enterocolitis, Malrotation, and Protein Losing Enteropathy.- Malnutrition and Feeding Difficulties: Guideline for Enteral and Parenteral Nutrition.- Hematological Aspects: Anticoagulation, Heparin_Induced Thrombocytopenia, Plasma Exchange.- Renal Failure and Replacement Therapy.- Neurological Complications: Intracranial Bleeding, Stroke, and Seizures.- Infections in the Cardiac Intensive Care Unit.- Skin Protection.

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Book SynopsisThis extensively updated textbook comprehensively reviews the latest developments in evidence-based critical care. Topics are covered in a case study format with an emphasis on the principles of diagnosis and therapy. Each topic is covered using a variety of case studies and features a case vignette, clinical question and an additional discussion section to clarify areas of particular importance. Topics including cytokine release syndrome, sympathomimetic overdose and palliative care in the intensive care unit have been extensively revised, while new sections focusing on neuromuscular disease and subarachnoid hemorrhages have been added. Evidence-Based Critical Care, 2nd edition is a critical resource for critical care practitioners, fellows, residents; allied health professionals and medical students who wish to expand their knowledge within critical care. The case study-based approach taken in the textbook makes this an ideal resource for those preparing for board examinations.Trade ReviewTable of ContentsSympathomimetic overdose (designer drugs).- Cardiac Arrest Management.- Beta blocker overdose.- Post- Cardiac Arrest Management.- Undifferentiated Shock.- Hypovolemic Shock and Massive Transfusion.- Acute Respiratory Failure.- Encephalitis.- Hyperkalemia NIV Implementation and Intubation.- Subarachnoid Hemorrhages.- Diagnosis and Management of Tricyclic Antidepressant Ingestion.- Hypernatremia.- Management of Calcium Channel Blocker Poisoning.- ICU Care Delivery and Medical Ethics.- Diagnosis and Management of Ethylene Glycol Ingestion.- Accidental Hypothermia.- Management of Cardiogenic Shock.- Management of Acute Heart Failure.- Management of Acute Coronary Syndrome.- Complications of Myocardial Infarction.- Management of Cardiac Tamponade.- Hypertensive Crises.- Atrial Fibrillation and Other Supraventricular Tachycardias.- Ventricular Arrhythmias.- Management of Acute Aortic Syndromes.- Management of Endocarditis.- Community Acquired Pneumonia.- Management of Acute Respiratory Distress Syndrome.- Acute Exacerbation of COPD: Non-Invasive Positive Pressure Ventilation.- Management of Status Asthmaticus.- Immunocompromised Pneumonia.- Venous Thromboembolism in the Intensive Care Unit.- Massive Hemoptysis.- Sedation and Delirium.- Prolonged Mechanical Ventilation.- Complications of trach.- Ventilator-Associated Pneumonia and Other Complications.- Respiratory Failure in a Patient with Idiopathic Pulmonary Fibrosis.- Weaning from Mechanical Ventilation.- The Post-Intensive Care Syndrome.- Management of Decompensated Right Ventricular Failure in the Intensive Care Unit.- Multi-disciplinary care/communication in the ICU.- Palliative care in ICU.- Family involvement in ICU.- Diffuse Alveolar Hemorrhage.- Acute Stroke Emergency Management.- Bacterial Meningitis in the ICU.- Management of Intracerebral Hemorrhage.- Status Epilepticus.- Neuroleptic Malignant Syndrome.- Traumatic Brain Injury.- Management of Anoxic Brain Injury.- Traditional and Novel Tools for Diagnosis of Acute Kidney Injury.- Management of Acute Kidney Injury.- Rhabdomyolysis.- Hyponatremia.- Management of Severe Hyponatremia and SIADH.- Diabetic Ketoacidosis.- Thyroid Storm.- Adrenal Insufficiency.- Management of Hyperglycemic Hyperosmolar Syndrome.- Management of Myxedema Coma.- Urosepsis.- Management of Sepsis and Septic Shock.- Invasive Aspergillus.- Management of Strongyloides Hyperinfection Syndrome.- Treatment of Viral Hemorrhagic Fever in a Well-Resourced Environment.- Management of Severe Malaria.- Dengue.- Chikungunya.- Leptospirosis.- Management of Acute Upper Gastrointestinal Hemorrhage.- Variceal Hemorrhage.- Acute Pancreatitis.- Management of Acute Liver Failure.- Acute Lower Gastrointestinal Bleeding.- Diagnosis and Management of Clostridium Difficile Infection (CDI).- Principles of Nutrition in the Critically Ill Patient.- Spontaneous Bacterial Peritonitis.- ICU Management of the Patient with Alcoholic Liver Disease.- Diagnosis and Management of Thrombotic.- Thrombocytopenic Purpura.- Acute Leukemia Presentation with DIC.- Disseminated Intravascular Coagulation.- Hemophagocytic Lymphohistiocytosis.- ICU Complications of Hematopoietic Stem Cell.- Transplantation Including Graft vs. Host Disease.- Tumor Lysis Syndrome.- Management of Hyperviscosity Syndromes.- Thoracic Trauma.- Blunt Abdominal Trauma.- Oncologic emergencies.- Abdominal Sepsis and Complicated Intraabdominal Infection.- Intestinal Obstruction: Small and Large Bowel.- Management of Acute Compartment Syndrome.- Extracorporeal Membrane Oxygenation (ECMO) and Extracorporeal CO2 Removal (ECCO2R).- Coagulopathy Management of Acute Thermal Injury.- Acute Arterial Ischemia.- Management of Necrotizing Soft Tissue Infection.- Cytokine release syndrome.- Biliary Infections.- Peripartum Cardiomyopathy.- Obstetric haemorrhage.- Management of Amniotic Fluid Embolism.- Respiratory Diseases of Pregnancy.- Preeclampsia, Eclampsia and HELLP Syndrome.- Management of Severe Skin Eruptions.- Management of Alcohol Withdrawal Syndromes.- End of Life Care in the ICU.- Neuromuscular Disease.

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Book SynopsisThis book acts as a portable and easy-to-understand reference for surgical trainees or young faculty members that are interested in reviewing procedures on the way to the operating room. This second edition aims to provide a practical hands-on approach to operative trauma management. Following the success of the first edition, chapters were revised, updated, and added due to substantial changes in trauma care over the past few years. Several new experts contributed their knowledge and techniques inside this new edition. For example, chapters on fasciotomy and resuscitative endovascular balloon occlusion of the aorta (REBOA) have been added.The second edition of The Shock Trauma Manual of Operative Techniques is a valuable reference for practicing surgeons in the community and serves to aid trauma practitioners as they attempt to deal with operative challenges.Table of Contents

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Book SynopsisThis book serves as the primary reference for precision medicine in the fields of pulmonary, critical care and sleep medicine by documenting principles written by experts in several aspects of precision medicine. It combines fundamental concepts of the field with state-of-the-art studies and how they translate into individual preventive, diagnostic and therapeutic plans. Precision medicine is focused on the integration of individual variability with disease prevention and treatment principles derived from population studies. This concept has risen to prominence in recent years in parallel with advances in genetics, molecular diagnostics and novel target-specific therapies. This fundamental shift in the approach to treatment has broad implications in how we prevent, diagnose and treat disease. Describing key concepts of precision medicine and relating these to pulmonary, critical care and sleep disorders is essential to educate relevant stakeholders and increase the impact of pulmonary precision medicine. The book is organized into seven sections: introduction; genetics; biomarkers; precise phenotyping; mobile health, wearables and telemedicine; precision therapeutics; and enabling widespread adoption of precision medicine. The chapters are organized with an introduction to the specific theme, followed by its basic concepts. They then delve into how these basic concepts relate to the larger theme of precision medicine, new precision medicine approaches to dealing with these problems, and key takeaway points. Liberally illustrated with images, figures, and tables, the text is thorough and intuitive for clinicians and researchers to learn the processes and applications of precision medicine. This is an ideal guide for clinicians to learn new precision medicine concepts in the fields of genetics, genomics, mobile health, and how they apply to their practice and their patients, as well as researchers seeking a basic understanding of precision medicine to assist in designing future research studies. Table of ContentsIntroduction.- Differential Diagnosis of Diffuse Pulmonary Disorders Using Genetics.- Genetics and Pharmacogenetics of Asthma.- Genetics and Pharmacogenetics of COPD.- The Evolution of Precision Medicine in Cystic Fibrosis.- Genetics of Idiopathic Pulmonary Fibrosis.- Genetics of Lung Cancer.- Chest Imaging for Precision Medicine.- Biobanking for Pulmonary, Critical Care, and Sleep Medicine.- Biomarkers in Obstructive Airway Diseases.- Biomarkers in Interstitial Lung Diseases.- Molecular Diagnostics in Pulmonary Infections.- Biomarkers in Critical Care Illness: ARDS and Sepsis.- Lessons for Precision Medicine from Lung Cancer.- COPD Phenotyping.- Precision Medicine in Pulmonary Hypertension.- Identifying Subtypes of Obstructive Sleep Apnea.- Precision Medicine in Critical Illness: Sepsis and Acute Respiratory Distress Syndrome.- Mobile Applications and Wearables for Chronic Respiratory Diseases Monitoring.- Personal Environmental Monitoring.- Tele-ICU in Precision Medicine: It’s Not What You Do It’s How You Do It.- Lung Transplantation and Precision Medicine.- Precision in Mechanical Ventilation.- Precision Medicine for Cigarette Smoking Addiction.- Implementing COPD Precision Medicine in Clinical Practice .- Precision Medicine For All: Minority Health .- Education for the Practice of Precision Medicine in PCCSM: Creating Tomorrow’s Workforce.- Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care and Sleep Medicine.

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Book SynopsisThis book presents the parameters of Mastery Learning (ML), an especially stringent variety of competency-based education that guides students to acquire essential knowledge and skill, measured rigorously against a minimum passing standard (MPS). As both a scholarly resource and a teaching tool, this is a “how to” book that serves as a resource for a wide variety of health professions educators.A seminal source of information and practical advice about ML, this book divided into five parts: Clinical Education in the Health Professions, The Mastery Learning Model, Mastery Learning in Action, Transfer of Training from Mastery Learning and The Road Ahead. Complete with high-quality images and tables, chapters take an in-depth look into ML principles and practices across the health professions. Specific educational content instructs readers on how to build and present ML curricula, evaluate short and long-run results, conduct learner debriefing and give powerful feedback, set learner achievement standards, and prepare faculty for new educational roles.An invaluable addition to the Comprehensive Healthcare Simulation Series, Mastery Learning in Health Professions Education is written and edited by leaders in the field for practicing clinicians in a variety of health professions.Table of ContentsDedicationTable of ContentsContributing AuthorsForeword (S. Barry Issenberg, MD)PrefacePART ONEClinical Education in the Health ProfessionsChapter 1. Clinical Education: Origins, Problems, and Uneven OutcomesWilliam C. McGaghie, PhD, Jeffrey H. Barsuk, MD, MS, and Diane B. Wayne, MDPART TWOThe Mastery Learning ModelChapter 2. Mastery Learning Model: Origins, Description, Evidence that it Works in Health Professions EducationWilliam C. McGaghie, PhDChapter 3. Developing a Mastery Learning CurriculumJeffrey H. Barsuk, MD, MS, Elaine R. Cohen, MEd, Diane B. Wayne, MD,William C. McGaghie, PhD, and David Salzman, MD, MEdChapter 4. Evaluating Mastery Learning OutcomesCelia O’Brien, PhD and Mark Adler, MD, MAChapter 5. Standard Setting for Mastery LearningDiane B. Wayne, MD and Elaine R. Cohen, MEdChapter 6. Implementing and Managing a Mastery Learning ProgramElaine R. Cohen, MEd and Diane B. Wayne, MDChapter 7. Feedback and Debriefing for Mastery Learning : Faculty as Coaches and MentorsWalter Eppich, MD, MEd and Mark Adler, MD, MAPART THREETransfer of Training from Mastery LearningChapter 8. Translational Outcomes from Mastery LearningWilliam C. McGaghie, PhD, Jeffrey H. Barsuk, MD, MS, Diane B. Wayne, MD,and Elaine R. Cohen, MEdChapter 9. Dissemination and Maintenance of Mastery Learning Educational ProgramsWilliam C. McGaghie, PhD, Jeffrey H. Barsuk, MD, MS, Elaine R. Cohen, MEd,and Diane B. Wayne, MDPART FOURChallenges and OpportunitiesChapter 10. Faculty Development for Mastery LearningWalter Eppich, MD, MEd and David Salzman, MD, MEdChapter 11. A New Horizon: Mastery Learning, Continuing Professional Education (CPE) and Maintenance of Certification (MOC)Clara Schroedl, MD, Brian McMahon, MD, MMSc and William C. McGaghie, PhDPART FIVEMastery Learning in ActionChapter 12. Mastery Learning of Clinical Communication SkillsGordon Wood, MD and Julia Vermylen, MDChapter 13. Mastery Learning of Team SkillsAashish Didwania, MD, et. alChapter 14. Mastery Learning of Surgical SkillsEric Hungness, MD, Ezra Teitelbaum, MD, Ben Schwab, MD,and Katherine Barsness, MDChapter 15. Mastery Learning of Bedside Procedural SkillsJeffrey H. Barsuk, MD, MS, Anessa Mikolajczak BSN, RN, and Stephanie Seburn, BSN, RNChapter 16. Mastery Learning of Medical EmergenciesWalter Eppich, MD, Mark Adler, MD, Marcelo Malakooti, MD, and Mary McBride, MDChapter 17. Readiness for Residency: Mastery Learning of Essential Clinical SkillsDavid Salzman, MD, MEd, Timothy W. Caprio, MD, Kathryn K. Hufmeyer, MD,and Nabil M. Issa, MDPART SIXThe Road AheadChapter 18: Mastery Learning, Entrustable Professional Activities, and Postgraduate Milestones Eric Holmboe, MD, David Salzman, MD, MEd, Joshua Goldstein, MD, and William C. McGaghie, PhDChapter 19.: Mastery Learning: Research Opportunities and ChallengesWilliam C. McGaghie, PhD, Jeffrey H. Barsuk, MD MS, Diane B. Wayne,, MDGlossaryName IndexSubject IndexChapter features: Tables, Figures, Examples, Cases, Reprinted Material (with permission)Chapter organization: Introduction (including chapter structure), sections (in order), summary

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Book SynopsisThis book focuses on the technical, cognitive, and behavioral skills needed to implement an extracorporeal membrane oxygenation (ECMO) simulation program. It describes these programs on the individual, team, and hospital system level, and includes the history of ECMO simulation, its evolution to its current state, and future directions of technology and science related to ECMO simulation. Divided into six sections, chapters describe both the theoretical as well as the practical aspects of ECMO simulation, including a pictorial guide to setting up an ECMO simulation circuit and how to recreate ECMO emergencies. It is a pragmatic guide that emphasizes the necessary practical items and discussions necessary to plan, set-up, orchestrate, and debrief ECMO simulations for different types of learners in different Comprehensive Healthcare Simulation: ECMO Simulation - A Theoretical and Practical Guide is part of the Comprehensive Healthcare Simulation Series, and this book is intended for educators, simulation technologists, and providers involved in ECMO programs who recognize the value of simulation to improve ECMO outcomes.Table of ContentsSECTION I: HISTORY OF ECMO & ECMO SIMULATION.- 1. ECMO from Conception to Execution.- 2. Simulating ECMO: Rationale and Genesis.- SECTION II: EDUCATIONAL THEORY BEHIND ECMO SIMULATION.- 3.The Critical Role of Simulation in ECMO Education.- 4. A Conceptual Framework for Development of a Simulation-Enhanced ECMO Training Program: Use of a Zone-Based Framework.- 5. Brain-Based Learning.- 6. Designing an ECMO Simulation Curriculum.- SECTION III: TECHNOLOGY FOR ECMO SIMULATION.- 7. Innovations and Options for ECMO Simulation.- 8. Physiologic Modeling.- 9. Immersive Technologies in ECMO Simulation.- SECTION IV: OTHER TOPICS FOR ECMO SIMULATION.- 10. Interprofessional Education and ECMO Simulation.- 11. Optimizing ECMO Teams: What Every ECMO Educator Needs to Know about the Latest Advances in Team Science.- SECTION V: PRACTICAL CONSIDERATIONS.- 12: Current Training Recommendations for ECMO Providers and Specialists.- 13: The Role of Simulation in Starting a New ECMO Program.- 14. Using Simulation to Develop an ECMO Transport Program.- 15. Debriefing ECMO Simulations: Special Considerations.- 16. Controversies on Certification of ECMO Practititioners Using Simulation.- 17. Research in ECMO Simulation: A Review of the Literature.- 18. Faculty Development for ECMO Simulation.- 19. Quality Improvement.- SECTION VI: SPECIAL CONSIDERATIONS FOR DIFFERENT ECMO POPULATIONS.- 20. Neonatology.- 21. ECMO Simulation in Infants, Children, and Adolescents.- 22. ECMO Simulation in Patients with Cardiac Disease.- 23. Surgical Considerations.- 24. Nursing Aspects of ECPR and ECMO Training.- 25. ECMO Simulation in the Adult Population - Proning, Awakening Breathing Trials, and Mobilization.- 26. The Role of Simulation in Training of ECMO Specialists.- SECTION VI: PRACTICAL GUIDE.- 27. A Practical and Pictorial Guide for Creating ECMO Simulation.

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Book SynopsisThis evidence-based guide is the first of its kind to outline the surgical and perioperative management of patients with anatomical anomalies and support clinical decision-making under these difficult circumstances. Presented in a simple, accessible format and organized by anatomical area, this book contains all the essential topics required by trainees and practitioners to assess the patient quickly, diagnose anatomic anomalies, determine the feasibility and safety of the planned surgical and anesthetic procedures, and arrange for advanced consults and care, if needed. Newer techniques for surgical and anesthetic management of patients with anatomic anomalies are presented to facilitate practitioners’ development of their skills. Chapters include the latest ultrasound techniques and images, as well as case studies.Physicians, nurses, and trainees involved in the surgical, anesthetic, perioperative, or critical care of patients will find this guide to be their go-to resource in the OR, lab, or pain clinic.Table of ContentsSection I: Head and Neck.- 1. Anatomy of the Head and Neck.- 2. Challenges of Dental Surgery and Oral and Maxillofacial Surgery in Patients with Anatomical Anomalies.- 3. Airway Management.- Section II: Thorax and Its Contents.- 4. Head and Neck Variations: Vessels.- 5. Head and Neck Variations: Soft Tissue, Nerves, and Bones.- 6. Common Congenital Syndromes and Disease States Impacting Regional Anesthesiology Techniques.- 7. Thoracic Aorta and Its Variants.- Section III: Abdominal Cavity.- 8. Anatomy of the Gastrointestinal System.- 9. Anomalies of the Gastrointestinal Tract.- 10. Surgical Anatomy of the Hepatobiliary System.- 11. Surgical Anatomy, Anomalies, and Normal Variants of the Pancreas.- 12. Anatomy of the Genitourinary System.- 13. Urologic Anomalies and Surgical Implications.- 14. Duodenal Fossae.- 15. Acquired Spinal Disorders Anatomy.- 16.- Neuraxial and Peripheral Nerve Block Placement in Patients with Anatomical Anomalies.- Section IV: Upper and Lower Extremities.- 17. Upper Extremity Variations.- 18. Anomalies of the Foot and Ankle.- 19. Upper and Lower Extremity Vascular Variations.- Section V: Vascular Access and Anesthesia.- 20. Vascular Access and Anesthesia for Patients with Cardiac Anatomic Anomalies. 

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Book SynopsisThe goal of the first edition of Interventional Critical Care: A Manual for Advanced Care Practitioners was to fill a knowledge gap of the advanced practice provider (APP) specifically regarding the skills and understanding of critical care procedures in response to the rapidly expanding participation of APPs in critical care. Written by experts in the field, this successor edition adds to the content of the first by expanding upon ultrasonography areas to include more direct hemodynamic evaluations as well as the newer “e”FAST. It also explores the specialty of Urology to include more complex interventions. As billing and coding are necessary, the authors added appropriate CPT codes for each of the appropriate chapters. Most chapters have been completely re-written and updated from the first edition and have different authors – thereby a different perspective and experience level. Interventional Critical Care 2nd Edition serves as a valuable reference for physicians and advanced practice providers in daily practice in the ICU, OR and/or ED setting.Table of ContentsThe Multi-Disciplinary ICU Team.- Process Improvement & Patient Safety.- The Administrative Process.- Coding and Billing for Procedures.- Airway Management in the ICU.- Rescue Airway Devices and Techniques.- Cricothyroidotomy.- Percutaneous Dilatational Tracheostomy, Open Surgical Tracheostomy and Management of Tracheostomy Tubes.- Diagnostic and Therapeutic Bronchoscopy.- REBOA (Resuscitative Endovascular Balloon Occlusion of the Aorta) Catheter.- Arterial Line Access and Monitoring.- Central Venous Catheterization with and without ultrasound guidance.- Hemodialysis Catheter Insertion.- Intraosseous Access Techniques in the ICU.- Pulmonary Artery Catheter Insertion.- Tourniquet Application and Topical Hemostatics.- Pericardiocentesis.- Temporary Transvenous and Transcutaneous Pacemakers.- Intra-Aortic Balloon Pump Counterpulsation.- Resuscitative Thoracotomy.- Extra Corporal Membrane Oxygenation and Extracorporal Life Support.- Thoracentesis.- Tube Thoracostomy.- Inferior Vena Cava Filters Insertion in the Critically Ill.- External Ventricular Drain Placement.- Intraparenchymal Fiber-optic Intracranial Pressure Monitoring.- Lumbar Puncture and Drainage.- Enteral Access.- Percutaneous Endoscopic Gastrostomy tube placement.- Paracentesis.- Abdominal Compartment Syndrome.- Abdominal Compartment Syndrome and Decompressive Laparotomy.- Bedside Laparoscopy in the Intensive Care Unit.- Diagnostic Peritoneal Lavage.- Foley Catheterization - Basic to Challenging.- Catherization of Atypical Urinary Reservoirs and Clot Evacuation.- Miscellaneous Urologic Problems.- Fracture Management: Basic Principles, Immobilization, and Splinting.- Fracture Management: Advanced Principles of Procedures for Stabilization.- Compartment Syndrome & Fasciotomies.- Wound Management in the ICU.- Escharotomy.- Extended Focused Abdominal Sonography in Trauma – eFAST.- Bedside Cardiac Ultrasound In The Intensive Care Unit.

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Book SynopsisThe latest edition of this handbook is a concise yet comprehensive guide for attending physicians, fellows, residents, and students who cover the ICU. The chapters follow an outline format and are divided by organ system, including neurologic disorders and cardiovascular disorders, and special topics, such as environmental disorders, trauma, and toxicology. The handbook includes thoroughly updated chapters from the previous edition, alongside completely new content.Written by an authority in the field, the Handbook of Critical and Intensive Care Medicine, Fourth Edition is a valuable one-stop reference for every practitioner engaged in Critical Care Medicine across the world. Trade ReviewTable of Contents

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Book SynopsisThis book provides a practically applicable guide to the use of ultrasound in the care of acutely and critically ill patients. It is laid out in two sections. The first section attempts to take a comprehensive approach to specific systems of examination taking an organ focused approach covering techniques including Focussed Assessment with Sonography for Trauma (FAST) scanning and venous sonography. The second section presents a range of specific cases enabling the reader to develop an understanding of how to apply these methodologies effectively into their day-to-day clinical practice.Ultrasound in the Critically Ill: A Practical Guide describes how to use ultrasound technologies in day-to-day clinical practice. Therefore, it is an ideal resource for all trainee and practicing physicians who utilize these technologies on a day-to-day basis. Table of ContentsPhysics of Ultrasound.- Preparation and Image Optimisation.- Clinical Governance.- Airway Ultrasound.- Basic Lung Ultrasound.- Advanced Lung Ultrasound.- Focused Transthoracic Echocardiography.- Advanced Transthoracic Echocardiography.- Transoesophageal Echocardiography.- FAST Scanning.- Renal Tract Ultrasound.- Abdominal Ultrasound - Liver, Spleen and Biliary Tree.- Abdominal Ultrasound - Bowel and Peritoneum.- Vascular Access.- Venous Sonography.- Neuro-ophthalmic Ultrasound.- Cranial Doppler.- Musculoskeletal Ultrasound.- The Haemodynamically Unstable Patient.- The Unconscious Polytrauma Patient.- The Patient with Acute Breathlessness.- The Patient Difficult to Wean from Mechanical Ventilation.- The Patient with Acute Kidney Injury.- The Patient with Acute Abdominal Pain.

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Book SynopsisThe Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.Table of ContentsPart I. Respiratory Issues.- Part II. ARDS.- Part III. Biomarkers.- Part IV. Fluids.- Part V. Hemodynamic Management.- Part VI. An unknown pandemics.- Part VII. Covid-19 associated coagulopathy.- Part VIII. Sepsis.- Part IX. Bleeding & Transfusion.- Part X. Prehospital Intervention.- Part XI. Neurological Aspects.- Part XII. Organ Donation.- Part XIII. Oncology.- Part XIV. Severe Complications.- Part XV. Prolonged Critical Illness.- Part XVI. Organizational and Ethical Aspects.- Part XVII. Artificial intelligence in the ICU.- Index.

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Book SynopsisThis book aims to be a single point of reference for advances in the care of geriatric populations across medical and surgical specialties. The aging population is a unique demographic with its own health challenges. Geriatricians are specifically trained to address these challenges but few medical students or residents enter geriatrics, even as the demand for geriatric expertise increases. The practices of many medical and surgical specialists are dominated by older patients who may themselves see many specialists but rarely visit geriatricians. This updated edition elucidates the most common medical conditions seen in aging patients and translates approaches to those conditions for physicians across specialties. Divided into three sections that assemble crosscutting issues, medical specialties, and surgical and related specialties, this book serves as a guide for clinicians of all backgrounds who will work with older patients as the demographic ages further.This second edition of Geriatrics for Specialists expands the number of specialist chapters to reflect growth in research in aging and clinical care for older people in dermatology, plastic surgery, and behavioral neurology. All original chapters from the first edition are extensively revised and updated to reflect the rapid growth of new knowledge in the field.Table of ContentsFrailty.- Delirium.- Preoperative Evaluation.- Psychiatric Disorders in Older Adults.- Medication Management.- Palliative Care and End-of-Life Issues.- Hospital Medicine.- Screening Tools for Geriatric Assessment by Specialists.- Cardiothoracic Surgery.- Emergency Medicine.- Geriatric Trauma and Emergency General Surgery.- Special Evidence-Based Considerations in Geriatric Gynecologic Care: Pelvic Floor Disorders.- Geriatric Cross-Cutting Issues in Ophthalmology.- Geriatric Orthopaedic Surgery.- Rehabilitation.- Urology.- Vascular Surgery.- Rheumatology.- Cardiovascular Disease.- Endocrinology.- Gastroenterology.- Infection and Immunity in Older Adults.- Kidney Disease.- A Geriatric Perspective on Oncology Care.- Pulmonary and Critical Care Medicine.- Behavioral Neurology.- Geriatric Dermatology.

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Book SynopsisThis book focuses on the placement of vascular access devices under emergent conditions, including the techniques and devices needed to achieve successful device deployment in even the most critically-ill patient.Up-to-date references and evidence for best practices are provided, informing both the novice and experienced healthcare provider. Each chapter is meticulously researched, including individual chapters focusing upon peripheral intravenous, intraosseous, central venous, and ultrasound-guided catheter placement. Device selection and emergent decision-making are discussed at length, including such crucial determinants as infusion flow rates, device limitations, issues with medication incompatibility, complications of line placement, and the relative indications and contraindications associated with various vascular access approaches.Emergent Vascular Access is an essential resource for any healthcare provider who places or manages vascular access devices in critically-ill patients, including emergency and ICU physicians, residents, rapid response providers, EMS paramedics, patient care technicians, medical students, and nurses.Table of ContentsChapter 1. What is Emergent Vascular Access?.- Chapter 2. The Anatomy of Vascular Access.- Chapter 3. The Physiology and Physics of Vascular Access.- Chapter 4. Types of Vascular Access Devices.- Chapter 5. Peripheral Intravenous (PIV) Devices.- Chapter 6. Central Venous Catheter Devices.- Chapter 7. Intraosseous Devices.- Chapter 8. Alternative Vascular Access Solutions.- Chapter 9. What is Difficult Vascular Access (DVA)?.- Chapter 10. Decision-Making in Emergent Vascular Access.- Chapter 11. High-Risk Presentations (e.g., Cardiac Arrest, Shock, etc.).- Chapter 12. The Future of Emergent Vascular Access.

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Book SynopsisThis book on post-injury multiple organ failure (MOF) offers a comprehensive overview and clinically focused practical guide to treating the condition. MOF is arguably the most difficult complication to manage in polytrauma patients and is responsible for the majority of trauma deaths among patients who survived the first 24 hours after injury. Beyond mortality, it has a major impact on healthcare resource utilization and a persistent negative effect on patients’ long-term reported outcomes. This book is edited by surgeons who are passionate about the topic, and about optimizing the outcomes for polytrauma patients. Grasping the fascinating pathophysiology of MOF is essential for providing patients with quality early care. Each chapter highlights key learning objectives, historical perspectives, diagnostic and therapeutic pearls, and includes a must-know summary, additional reading suggestions and future research directions. Flowcharts, decision-making guides, summary tables, graphics and clinical photographs help to maximize the learning experience and to ensure readers retain what they’ve learned. The book fills a unique niche area for many specialties dedicated to critical care of polytrauma patients and to their management before and beyond intensive care. Table of Contents1 Historic perspective and relevant evolutionary landmarks in trauma care.- 2 The definition of postinjury Multiple Organ Failure.- 3 The pathomechanism of postinjury MOF.- 4 Genomic considerations related to postinjury MOF.- 5 The epidemiology of postinjury MOF.- 6 The relevance of traumatic shock and its treatment on the epidemiology of MOF.- 7 The relevance of the timing of surgical interventions.- 8 The population at risk, predictors of MOF.- 9 Postinjury MOF with and without infection.- 10 The principles of treatment, modern therapeutic targets.- 11 Central nervous system.- 12 Respiratory failure.- 13 Cardiac failure.- 14 Liver failure.- 15 Gastrointestinal failure, clinical presentations and treatment.- 16 Kidney failure.- 17 Bone marrow failure.- 18 MOF management in low resource settings.- 19 MOF in pregnancy and its relevance to Eclampsia.- 20 MOF in paediatric patients.- 21 Summary of randomised controlled trials with significant effect on MOF outcomes.- 22 Iatrogenic causes leading to MOF.- 23 Short term outcomes, what has changed during the last 40 years?.- 24 Long term outcomes and functional outcomes.- 25 Future directions.

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Book SynopsisThe Annual Update compiles reviews of the most recent developments in clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in intensive care and emergency medicine, anesthesia, surgery, internal medicine, and pediatrics.Table of ContentsSepsis and the Immune Response.- The role of mitochondria in the immune response in critical illness.- Immunomodulation by tetracyclines in the critically ill: an emerging treatment option?.- Hit early: blocking interleukin-1 in the treatment of COVID-19 pneumonia.- Hemoadsorption therapy during ECMO: emerging evidence.- Respiratory Issues.- The forgotten circulation and transpulmonary pressure gradients.- Oxygen: origin, pathophysiology, and use in the critically ill.- Nebulized therapeutics for COVID-19 pneumonia in critical care.- Mechanical Ventilation.- Positive end-expiratory pressure in invasive and non-invasive ventilation of COVID-19 ARDS.- Personalized mechanical ventilation setting: slow is better!.- Spontaneous breathing in acute respiratory failure.- Laryngeal injury: impact on patients in the acute and chronic phases.- Fluids and Electrolytes.- Fluid responsiveness as a physiologic endpoint to improve successful weaning.- Tidal volume challenge test: expanding possibilities.- Fluid management in COVID-19 ICU patients.- Electrolytes in the ICU.- Renal Failure.- Hemodynamic alterations during continuous renal replacement therapy: is it all about fluid?.- How to prolong filter life during continuous renal replacement therapy?.- Prevention of acute kidney injury after cardiac surgery.- Circulatory Shock.- Contrast enhanced renal ultrasound: an emerging technique for assessment of renal perfusion in critically ill patients.- Focused clinical hemodynamic assessment in septic shock.- Vasopressor choice and timing in vasodilatory shock.- Cardiac arrest.- Advanced life support update.- Brain injury biomarkers for predicting outcome after cardiac arrest.- Neurocritical care and Neuromonitoring.- The emerging role of the microbiota in neurocritical care.- Brain-multiorgan cross-talk in critically ill patients with acute brain injury.- The importance of neuromonitoring in non-brain injured patients.- Artificial intelligence.- Artificial intelligence in critical care medicine.- Artificial intelligence in infection management in the ICU.- Quality of care.- Acute medical rehabilitation in intensive care.- Sepsis performance improvement programs: from evidence towards clinical implementation.

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Book SynopsisThis book provides healthcare professionals in Critical Care setting an easy consultation guide to fight against COVID-19. The book is divided into sections: Fundamentals of COVID-19, Pneumological critical care, Neurological manifestations, Cardiovascular manifestations, Renal manifestations, Haemostasis and coagulation, Other multi-organs involvement, Principles of therapy. Each section includes: · brief pathophysiology of COVID-19 (ventilation, neurological, cardiovascular, etc.); · principles of management (enriched with flowcharts and figures); · principles of therapy; · tips and key messages. Readers can find the most updated advices on how to face the ongoing pandemic: from principles of conventional oxygen therapy, assisted and invasive mechanical ventilation in critically ill COVID-19 patients to the complications sometimes underestimated. Tables and flowcharts provided are based on current knowledge in COVID-19 to help the clinician managing COVID-19 patients by a multiple-organs prospective. Written by international key opinion leaders of each field, the book represents a point of reference for all professionals involved in the management of COVID-19 pandemic.Table of Contents

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Book SynopsisThis textbook is a fully updated and revised third edition of a highly successful practical guide to the care of the polytrauma patient. Broadening its readership to students, this new edition comprehensively describes the clinical course of multiple and severe injuries, from the accident scene to rehabilitation.It provides essential practical information on the care of patients both with blunt and penetrating trauma to multiple body regions, and discusses the management of truncal injuries (head, chest, abdomen) as well as fractures of the extremities, pelvis and spine. Further, the book highlights associated injuries that may alter decisions concerning patients with polytrauma. This new, revised edition takes full account of recent developments, including the increasing economic pressure on health care systems, prehospital treatment, changes in trauma systems and related education, and the improved survival of polytrauma patients. Also covering improved monitoring options along with issues in late patient outcomes and rehabilitation this work will greatly assist students, emergency personnel, trauma surgeons, orthopaedic traumatologists, and anesthesiologists.Table of ContentsI Introduction: 1 Impact of Trauma on Society.- 2: Economic Aspects of Trauma Care.- 3: Evidence-Based Trauma Care - the role of COTS.- II ACUTE PERIOD (1 to 3 hours) / Prehospital Phase and Trauma Bay.- 4: Rescue Strategies and Trauma System.- 5: Preclinical Maganement.- 6: Initial Assessment and Diagnistics.- 7: Volume and Blood Management.- 8: Emergency Interventions.- III PRIMARY PERIOD (First 72 hours) / Clinical Phase.- PATHOPHYSIOLOGY, Ch 9: Coagulopathy.- PATHOPHYSIOLOGY, Ch 10: Inflammation and Immunosupression.- PATHOPHYSIOLOGY Ch 11: Remote Organ Injury.- PATHOPHYSIOLOGY Ch 12: Polytrauma Scoring.- CERTAIN INJURIES Ch 13: Head Injuries.- CERTAIN INJURIES Ch 14: Injury of the Face.- CERTAIN INJURIES, Ch 15: Chest Trauma.- CERTAIN INJURIES, Ch 16: Abdominal Injuries.- CERTAIN INJURIES, Ch 17: Penetrating Thorax and Abdominal Trauma.- CERTAIN INJURIES Ch 18: Management of the Pelvic Ring .- CERTAI INJURIES, Ch 19: Spine Fractures.- CERTAININJURIES, Ch 20: Spinal Cord Injuries.- CERTAIN INJURIES, Ch 21: Urological Injuries in Polytrauma.- CERTAIN INJURIES, Ch 22: Gynecological Injuries /Pragnant Patient in Polytrauma.- CERTAIN INJURIES, Ch 23: Vascular Injuries.- CERTAIN INJURIES, Ch 24: Compartment Syndrom.- SURGICAL MANAGEMENT, Ch 25: Damage Control in Abdomen and Thorax.- SURGICAL MANAGEMENT, Ch 26: Fracture Management / DCO.- SURGICAL MANAGEMENT, Ch 27: Managled Extremity.- SURGICAL MANAGEMENT, Ch 28: Elderly Patient with Polytrauma.- SURGICAL MANAGEMENT Ch 29: Polytrauma in Children.- SURGICAL MANAGEMENT Ch 30: Management of Traumatic Bone Defects.- SURGICAL MANAGEMENT Ch 31: Acute Soft Tissues and Bone Infections.- III SECONDARY PERIOD (3 to 8 days).- ICU MANAGEMENT CH 32: DIC.- ICU MANAGEMENT CH 33: Polytrauma and Sepsis.- ICU MANAGEMENT CH 34: Polytrauma and Multiple Organ Failure.- ICU MANAGEMENT Ch 35: General Management in the Elderly on ICU.- ICU MANAGEMENT Ch 36: Clearing Patients for Surgery.- ICU MANAGEMENT Ch 37: Complications.- IV TERTIARY PERIOD (after 8 days) / Rehabilitation.- Rehabilitation Ch 38 : Rehabilitation Strategies in Polytrauma.- Rehabilitation Ch 39 : Outcome Scores.- Rehabilitation Ch 40: Treatment of Acute and Chronic Osteomyelitis.- Rehabilitation Ch 41: Management of Malunions and Nonunions in Patients with Multiple Injuries.- Rehabilitation Ch 42: Reconstructive Strategies for Skeletal Complications.- Rehabilitation Ch 43: Soft Tissue Coverage.- Rehabilitation Ch 44: Treatment of Heterotopic Ossification.- Rehabilitation Ch 45: Psychological Squelae After Severe Trauma.- Rehabilitation Ch 46: General Outcome and Quality of Life.

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Book SynopsisThis book provides easy consultation and guidance for an appropriate understanding and management of endotoxic shock. Endotoxic shock results from a severe, generalized inflammatory response induced by bloodstream infection with gram-negative bacteria. However, endotoxin-induced inflammatory activation may be disconnected by Gram-Negative threats (e.g. Gram-Positive and yeast infections) as well as occur in multiple clinical scenarios like post-cardiac arrest syndrome and trauma, possibly due to gut barrier dysfunction and consequent endotoxin translocation. The clinical management is structured focusing and dedicating a chapter for antibiotics, corticosteroids, volume support, vasoactive and cardiostimulating drug, coagulopathy and nutritional support. In addition, this book is remarkable because describing polymixin b hemoperfusion points out molecular interactions, and hydrodynamics of Sorption. Each section includes •) brief pathophysiology; •) principles of management; •) key messages. Readers can find updated tips related to the diagnosis and management of endotoxic shock with a multidisciplinary approach drawing a pathway from endotoxin structure and source and the related pathophysiology of endotoxic shock underling the specific clinical aspect and focusing on medical clinical management of endotoxemia and extracorporeal removal. The book – written by international opinion leaders of this field – is addressed to healthcare providers working in intensive care and represents a point of reference for intensivists, infectious disease physicians, nephrologists and critical care nurses involved in the management of endotoxic shock and enriched with useful downloadable material.Table of ContentsEndotoxin: Structure Source and Effects.- Pathophysiology of Endotoxic Shock.- Host Resistance to Endotoxic Shock.- Endotoxin and Organ Cross-talk.- Endotoxin Measurement in Septic Shock.- Clinical Management of Endotoxemia: Antibiotics.- Clinical Management of endotoxemia: volume support.- Clinical Management of Endotoxemia: Corticosteroids.- Clinical Management of Endotoxemia: Vasoactive and Cardiostimulant Drugs.- Clinical Management of Endotoxemia: Source Control.- Clinical Management of Endotoxemia: Treatment of DIC.- Clinical Management of Endotoxemia: Metabolic and Nutritional Support.- Strategies to Reduce Endotoxin Activities.- Extracorporeal Removal of Endotoxin.

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Book SynopsisThe Annual Update compiles reviews of the most recent developments in clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in intensive care and emergency medicine, anesthesia, surgery, internal medicine, and pediatrics.Table of ContentsPart I. Precision Medicine.- The role of transcriptomics in redefining critical illness.- Metagenomic sequencing in the ICU for precision diagnosis of critical infectious illnesses.- Risk stratification and precision medicine: is it feasible for severe infections?.- Interrogating the sepsis host immune response using cytomics.- Precision medicine in septic shock.- Part II. Sepsis Biomarkers And Organ Dysfunction Scores.- Host response biomarkers for sepsis In the emergency room.- Repetitive assessment of biomarker combinations as a new paradigm to detect sepsis early.- Organ dysfunction scores in the adult ICU.- Part III. ARDS.- Ex vivo lung perfusion models to explore the pathobiology of ARDS.- Interpretation of lung perfusion in ARDS.- A structured diagnostic algorithm for patients with ARDS.- Hemodynamic implications of prone positioning in patients with ARDS.- Part IV. Ventilatory Support.- Update on the management of acute respiratory failure using non-invasive ventilation and pulse oximetry.- Managing the physiologically difficult airway in critically ill adults.- Dyspnea in patients receiving invasive mechanical ventilation.- The potential risks of pressure support ventilation.- Advancing sedation strategies to improve clinical outcomes in ventilated critically ill patients.- Part V. Extracorporeal Support Setting and monitoring of mechanical ventilation during venovenous ECMO.- Early mobilization of patients receiving ECMO for respiratory failure.- Physiological adaptations during weaning from venovenous ECMO.- Novel strategies to enhance the efficiency of extracorporeal CO2.- Extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic approach.- Temporary and durable mechanical circulatory support in the ICU.- Part VI. Fluids and Transfusion.- Venous congestion: why examine the abdomen with ultrasound in critically ill patients?.- The most important questions in the current practice of transfusion of critically bleeding patients.- Part VII. Acute Renal Failure.- Fluid management and acute kidney injury.- Cardiorenal syndrome 1: what’s in a name?.- Part VIII. The Microcirculation and Metabolism.- Update on the microcirculatory assessment of the critically ill patient.- Intracellular measurements of micronutrients in critically ill patients.- Optimal glycemic targets in critically ill patients with diabetes.- Part IX: A Look Back at COVID-19.- Hydroxychloroquine: time for reappraisal of its effect in COVID-19 patients.- Blood purification in COVID-19 outside acute kidney injury.- Part X. Neurologic Considerations.- Epidemiology, outcomes and costs of pediatric traumatic brain injury patients treated in the ICU.- Quality improvements in the determination of death by neurologic criteria around the world.- Part XI. Obstetric Issues.- COVID-19-induced ARDS in pregnancy: implications for the non-COVID era.- Amniotic fluid embolism.- Part XII. Pre and Post-Intensive Care.- Remote telehealth aid during humanitarian crisis.- Boarding in the emergency department: challenges and success strategies to mitigate the current crisis.- Post-intensive care syndrome revisited in light of the COVID-19 pandemic.- Part XIII. Ethical Issues.- Rethinking the role of palliative care in the ICU.

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Book SynopsisThis book, written by internationally renowned experts, is a comprehensive text covering all aspects and recommendations regarding the use of POCUS for critically ill neonates and children. Point of Care Ultrasound (POCUS) for the Neonatal and Pediatric Intensivist is structured to address and expand upon recently published international evidence-based POCUS guidelines endorsed by the European Society of Paediatric and Neonatal Intensive Care (ESPNIC). The book is richly illustrated and includes a robust collection of individual POCUS images and cases. The Electronic Supplementary Materials offer high quality and interesting video clips complementing reader learning, particularly for neonatology, pediatric critical care, and general pediatric providers. Chapter authors provide a practical, experience-based approach to clinical integration of POCUS applications and highlight relevant supportive literature as well as important limitations to POCUS use in the management of critically ill children. The information within the book is also intended to support further clinical and educational research in the practice of pediatric POCUS.Table of ContentsBasics in Critical Care and Neonatal Focused Ultrasound.- Hemodynamic Assessment.- Thoracic Assessment.- Abdominal Assessment.- Neurosonology.- Focused Ultrasound in Transport Setting.- Procedural Ultrasound.- Programmatic Considerations and Moving Forward.- Appendix.

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