Infectious and contagious diseases Books

Book SynopsisIn this book Michaela Gloeckler gives new inspiring perspectives on the significant role of the human heart in the development of the immune system, from early embryological growth through to adulthood. She explains the importance this has for an understanding not only of immunity but also conscience and common sense, hence also of the Covid crisi

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Book SynopsisThis Atlas of Dermatology has a unique clinical orientation with an emphasis on morphology. The disease entities are arranged according to the morphology of lesions to aid diagnosis. This pattern of placement is more useful for both teaching and learning and serves as an important aid in making a diagnosis being based on the way patients present themselves in out-patient departments. With key diagnostic clinical pointers generously illustrated to help the reader in diagnosing and excluding clinical differentials, this Atlas will serve as a helpful source for medical residents and practitioners specialising in Clinical Dermatology.Key Features An atlas and text covering skin, mucosa, hair and nail diseases in skin of color Emphasis on key diagnostic clinical pointers 3000+ clinical images--multiple images of a disease to cover the clinical spectrum Dedicated section on Regional Dermatology and Skin changes in systemic diseases Table of ContentsForeword by Debabrata Bandyopadhyay. Foreword by Eckart Haneke. Preface. Acknowledgements. Editors. Assistant editors. Contributors. INTRODUCTION TO CLINICAL DERMATOLOGY. Overview of skin lesions. APPROACH TO CLINICAL DIAGNOSIS. Hypopigmented and depigmented macules and patches: Localized. Hypopigmented and depigmented macules and patches: Generalized. Hyperpigmented macules and patches: Localized. Acquired facial melanosis. Hyperpigmented macules and patches: Generalized. Diffuse hyperpigmentation. Reticulate and mottled pigmentation. Papules: Localized. Facial papules. Papules: Generalized. Follicular papules. Plaques: Localized. Plaques: Generalized. Nodules: Localized. Nodules: Generalized. Tumors. Vesicobullous lesions: Localized. Vesicobullous lesions: Generalized. Pustules: Localized. Pustules: Generalized. Clinical approach to ulcers. Ulcer: Single or few. Leg ulcers. Ulcers: Multiple. Scales: Localized. Scales: Generalized. Atrophy. Purpura. Erythema: Localized. Erythema: Generalized. Telangiectasia. Cysts and pseudocysts. Draining sinuses and fistulas. Eschar. Cutaneous horn. REGIONAL DERMATOLOGY. Scalp. Periorbital area. Ears. Nose. Oral mucosa. Tongue. Axillae and groins. Umbilicus and periumbilical region. Palms and soles. Male genitalia. Female genitalia. Nipple areola complex. Scrotum. Seborrheic area. Intertriginous areas. Nails. SKIN IN SYSTEMIC DISEASES. Nutritional deficiency disorders. Endocrine disorders. Renal disorders. Autoimmune rheumatic diseases. Hereditary disorders of connective tissue. Hepatic diseases. Cardiovascular diseases. Neurocutaneous conditions. Psychocutaneous disorders. Dermatoses in HIV-infected persons. Internal malignancy. Nails in systemic disease. MISCELLANEOUS. Head and neck mass. Red face. Leonine facies. Linear lesions. Annular lesions. Alopecia. Hypertrichosis and hirsutism. Vascular lesions. Vasculitis. Neonatal dermatology. Geriatric dermatoses. Dermatoses of pregnancy. Cutaneous adverse drug reactions. Dermatitis artefacta, dermatitis neglecta, and terra firma-forme dermatosis. Pruritus SineMateria. Hyperhidrosis. Anhidrosis. Photosensitivity in children. Photosensitivity in adults. Maculopapular rash. Fever with rash in children. Index.

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Book SynopsisA Brief Social History of Tuberculosis delves into the history of tuberculosis and its impact on human populations.Drawing on research and expertexperiences, the three research chapters (3-5) will explore how the disease has affected communities throughout history, and how society has responded to the threat of tuberculosis over time. Tuberculosis has been a persistent and devastating force from the crowded cities of the Industrial Revolution to the present day. However, this book will argue that there is much to be learned from the successes and failures of past efforts to control the disease from a social perspective. By examining the history of tuberculosis, researchers and policymakers can gain valuable insights into the challenges of infectious disease control, as well as the social and political factors that shape our response to such challenges.This volume will focus on generating critical discussions among scholars, researchers, and policymakers, this wi

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Book SynopsisIncludes unique photos from staff telling their stories as well as some photos of NHS murals from the artists.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisWinner of the 2017 Jabuti Book Prize The Zika virus is devastating lives and communities. Children across the Americas are being born with severe disabilities because of it. Yet during the desolating outbreak, Brazil played host to both the Olympics and the FIFA World Cup, leading many to suspect that the true impact of the virus has been subject to a cover-up of international proportions. Beginning in the northeast, where the devastation has been most felt, professor of bioethics and award-winning documentary filmmaker Debora Diniz travels across Brazil tracing the virus’s origin and spread. Along the journey she meets a host of fearless families, doctors and scientists uncovering the virus’s impact on local communities. In doing so Diniz paints a vivid picture of the Zika epidemic, exposing the Brazilian government’s complicity in allowing the virus to spread while championing the efforts of local doctors and mothers who, working together, are raising awareness of the virus and fighting for the rights of children affected by Zika.Trade ReviewCaptivating … the reader is moved through the interviews on a page-turning, well written, and carefully constructed narrative arch. Nevertheless, the book’s greatest strength is that it is based on scientifically sound and well conducted ethnographic research. * The Lancet *Ingeniously crafted and affectingly narrated, Zika is a momentous contribution to the critical study of science and global health. * João Biehl, Princeton University *A masterfully researched and wide-ranging narrative of Zika in Brazil. Unforgettable. * Kearsley Stewart, Duke University *A compassionate and inclusive look at the impact of the Zika epidemic: from the mothers of affected babies to the race for an effective treatment. * Laura Rodrigues, London School of Hygiene & Tropical Medicine *Diniz illustrates the devastating effects that Zika’s spread has had on impoverished women, and how government scientists and policy makers failed to live up to their responsibilities toward those affected. A brilliant read, highly recommended! * Udo Schuklenk, Queen’s University, Canada *Table of ContentsTranslator’s Note Principle Characters Timeline Map 1. Telling the Story 2. Positive for Zika Where it All Began Deciphering an Allergy Epidemic A Mysterious Illness Strikes Bahia 3. The First Generation of Women The Foreigner The Northeasterners 4. Footprints of the Virus The Paralyzing Syndrome The Neuropediatricians from Recife The Doctor from Rural Paraíba 5. Patient Zero 6. The Aftermath 7. Implications for Women Worldwide

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Book SynopsisLeprosy is a chronic infectious disease that mainly affects the skin and peripheral nerves. Left untreated, it can cause progressive and permanent disability. But a diagnosis of leprosy can have consequences that go far beyond the disease's physical manifestations. The age-old stigma associated with leprosy can result in severe social discrimination that robs people of opportunities in life and condemns them to society's margins. This book is the most detailed account yet of Yohei Sasakawa's quest, over two decades as WHO Goodwill Ambassador for Leprosy Elimination, to work for a world without leprosy and the discrimination it causes. It chronicles his travels to remote communities around the world to hear directly from those affected by the disease, as well as his meetings with policy- makers, government leaders and heads of state to advocate for renewed commitment to the fight against leprosy, including measures to protect the human rights of those it affects. While much progress has been made, completing 'the last mile' in leprosy eradication is the hardest part of the journey. Making the Impossible Possible highlights the author's unflagging resolve to ensure that all involved stay the course.

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In this panoramic and up-to-date account, we learn how the Black Death, smallpox, the Spanish flu and other great epidemics have led to enormous sufferings and mass death, as well as contributing to the fall of empires and changing the course of history. We also discover how new infectious diseases such as HIV/AIDS and COVID-19 emerge. Man has struck back at the microbes; antibiotics and new vaccines have saved millions of lives - but the battle with these relentless, silent enemies is far from won. We face increasing threats from new and unavoidable pandemics, antibiotic resistance and extra-terrestrial microbes. Duel Without End is a fascinating journey through the long history of infection, from the dawn of life to humanity's future exploration of deep space.

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Book Synopsis Expanding our understanding of contagion beyond the typical notions of infection and pandemics, this book widens the field to include the concept of biosocial epidemics. The chapters propose varied and detailed answers to questions about epidemics and their contagious potential for specific infections and non-infectious conditions. Together they explore how inseparable social and biological processes configure co-existing influences, which create epidemics, and in doing so stress the role of social inequality in these processes. The authors compellingly show that epidemics do not spread evenly in populations or through simple coincidental biological contagion: they are biosocially structured and selective, and happen under specific economic, political and environmental conditions. This volume illustrates that an understanding of biosocial factors is vital for ensuring effective strategies for the containment of epidemics.Trade Review “The book will be useful to medical anthropologists, public health workers, and other health care providers…Recommended.” • Choice “Challenging the notion that some diseases are non-communicable, [this book] offers an original and coherent argument for rethinking the relations between the biological and the social, but also for thinking through the communicability of conditions through the social, using concepts such as contagion and contamination, configuration and conflagration.” • Ruth Jane Prince, University of OsloTable of Contents List of Figures Introduction: Configuring Contagion in Biosocial epidemics Lotte Meinert and Jens Seeberg Chapter 1. Gender Configurations and Suicide in Northern Uganda Susan Whyte and Henry Oboke Chapter 2. Configuring Epidemic Suicide in Oceania Ted Lowe Chapter 3. Haunted by the Future: Autism and the Spectre of Prison – Configuring Race and Disability in the African American Community Cheryl Mattingly and Stephanie Keeney Parks Chapter 4. Configuring Affection: Family Experiences of Obesity and Social Contagion in Denmark Lone Grøn Chapter 5. Health Activists and Trauma Contagion: Cultural Epidemics and Raising Awareness of Trauma in Post-conflict, Post-tsunami Aceh Jesse Hession Grayman, Mary-Jo DelVeccio Good and Byron Good Chapter 6. Touched by Violence: Configuring Affliction after War in Northern Uganda Lars Williams and Lotte Meinert Chapter 7. ‘These Spirit Attacks are Like an Epidemic’: Spirit Possession as Affective Contagion in Niger Adeline Masquelier, Abouzeidi Maidouka Dillé and Ly Amadou H. Belko Chapter 8. Haunted by Internet Porn: Configuration of a Hidden Contagion Doug Hollan Chapter 9. Contagious Configurations: Reproductive Governance from Abortion to Zika virus in Latin America Lynn M. Morgan Chapter 10. Figures of Drug-Resistant Tuberculosis. Jens Seeberg, Bijaylaxmi Rautray and Shyama Mohapatra Afterword: Epidemics and Ghosts Byron Good Index

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Book SynopsisSt Francis of Assisi, one of the most acclaimed and enduring of saints, is particularly significant when reflecting upon the COVID pandemic. Francis lived, and ministered, amid a leprosy pandemic. How he lived in relation to that pandemic makes him a source of insight to as well as a potential critic of contemporary responses to COVID. In turn, one can use COVID to question Francis. Did he exhibit a harmful form of religious devotion, perhaps fanaticism, by exposing himself and others to a lethal pathogen? This edited collection examines a highly visible and impactful religious figure with the intent of bringing him into conversation with one of the defining issues of the early 21st Century.Trade Review"These timely essays help us, who strive to live by Franciscan values, do more than ponder our role in a world of easy sickness. What are we called to do? What does it mean to be responsible to God, ourselves, and others? I m thankful for these writers." Jon M. Sweeney, editor of The Complete Francis of Assisi and author of Feed the Wolf

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Book SynopsisThis book should be read by anyone who will enjoy and also be deeply moved by an enthralling true story of a love affair tragically cut short. 'Sugar Upon My Lemons' is a heart-warming account of courtship, love, marriage and loss. The book also explores the human capacity for growth despite grief. The reader is invited to reflect upon how change and pain can be survived and worked through. Ultimately, it's a book of hope that offers a way forward for the future. It is an honest, thought-provoking and engaging page-turner.

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Book SynopsisNow in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: DNA Viruses, Seventh Edition covers the latest information on DNA viruses, how they cause disease, including cancer, how they persist in the body in a latent form, reactivate and spread, new therapeutics and vaccine approaches, as provided in new or extensively revised chapters that reflect these advances in this dynamic field. Bundled with the eBook, which will be updated regularly as new information about each virus is available, this text serves as the authoritative, up-to-date reference book for virologists, infectious disease specialists, microbiologists, and physicians, as well as medical students pursuing a career in infectious diseases. Covers both basic science and medical features of each virus, emphasizing viruses of medical importance and interest, while also including other viruses in specific cases where more is known about their mechanisms of replication or pathogenesis. Covers viruses that cause human cancer such as human papillomaviruses (HPV), Epstein Barr Virus, the Merkel Cell Polyomavirus and hepatitis B virus, and viruses like the herpesviruses that persist in a latent form and can reactivate and cause acute and/or chronic disease. Features more than 400 full-color illustrations, including key figures for use as lecture slides. Provides quick, flexible access to current information both in print and in an improved eBook format. Discusses virus structure, virus entry, replication, and assembly, virus-host cell interactions, host immune responses and vaccines, antiviral therapeutics, viral persistence and latency and viruses as tools for gene therapy and vectors for vaccination. New and forthcoming Field’s Virology volumes, available in print and eBook format: • Emerging Viruses • DNA Viruses • RNA Viruses • Fundamental Viruses Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

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Book SynopsisFor many residents of Western nations, COVID-19 was the first time they experienced the effects of an uncontrolled epidemic. This is in part due to a series of little-known regulations that have aimed to protect the global north from epidemic threats for the last two centuries, starting with International Sanitary Conferences in 1851 and culminating in the present with the International Health Regulations, which organize epidemic responses through the World Health Organization. Unlike other equity-focused global health initiatives, their mission—to establish "the maximum protections from infectious disease with the minimum effect on trade and traffic"—has remained the same since their founding. Using this as his starting point, Alexandre White reveals the Western capitalist interests, racism and xenophobia, and political power plays underpinning the regulatory efforts that came out of the project to manage the international spread of infectious disease. He examines how these regulations are formatted; how their framers conceive of epidemic spread; and the types of bodies and spaces it is suggested that these regulations map onto. Proposing a modified reinterpretation of Edward Said's concept of orientalism, White invites us to consider "epidemic orientalism" as a framework within which to explore the imperial and colonial roots of modern epidemic disease control.Trade Review"White writes critically and necessarily on the historical actions taken to prevent the spread of infectious disease. With great care, he deftly unpacks the racial and economic costs of global health initiatives and examines the ideals behind their genesis. The book is a remarkable and necessary re-thinking of medical history through the lens of 'epidemic orientalism'."—Hollie Sherwood-Martin, The Lancet Infectious Diseases"Over the course of his monograph, White successfully illustrates how an epidemic Orientalist worldview ultimately weakens epidemic responses and places the health of people on both sides of an imagined divide at a greater risk.... Historians and medical anthropologists and sociologists looking for a thoughtful synthesis of several intellectual frameworks for understanding medicine and empire will find Epidemic Orientalism a useful text."—Molly Walker, H-Sci-Med-TechTable of ContentsIntroduction 1. Epidemic Orientalism 2. The International Sanitary Conventions at a Colonial Scale 3. Epidemics under the WHO 4. The Battle to Police Disease 5. Epidemics, Power, and the Global Management of Disease Risk 6. Pricing Pandemics Conclusion

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Book SynopsisThis concise, beautifully illustrated book provides a convenient introduction to the basic science of medical microbiology and how this relates to clinical practice. Expanded from the prize-winning first edition to cover virology and parasitology in addition to bacteriology, this second editions explains the essentials of microbial infection and continues to provide a sound basis for developing logical diagnostic and management strategies, including the critical area of antibiotic usage. Section One focuses on the clinical with chapters centred around infections of the organ systems, while full coverage of the scientific aspects underpinning microbial disease follows in Section Two. Table of ContentsSection One: Clinical Aspects of Microbial Infection. Introduction to Clinical Microbiology. Anti-Infective Guidelines in the Hospital. The Clinical Microbiology Laboratory. Preventing Disease and Infection Control. Infections of the Blood. Infections of the Urinary Tract. Infections of the Respiratory Tract. Tuberculosis. Infections of the Liver including Viral Hepatitis. Infections of the Nervous System. Infections of the Skin, Soft Tissues, Bones and Joints. Infections in a Modern Society. Section Two: Scientific Basis of Microbial Infection. The Structure and Function of Prokaryotic and Eukaryotic Cell. The Classification of Bacteria, Fungi and Parasites. The Structure and Replication of Viruses. How Organisms Cause Disease. The Science of Anti-infective Agents and Resistance. Appendix One: Notifiable Diseases. Appendix Two: Key Point Summary of Organisms and Conditions.

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Book SynopsisInstant #1 New York Times bestseller! • #1 Washington Post bestseller! • #1 Indie Bestseller! • USA Today Bestseller!John Green, acclaimed author and passionate advocate for global healthcare reform, tells a deeply human story illuminating the fight against the world’s deadliest infectious disease. Signed edition“The real magic of Green’s writing is the deeply considerate, human touch that goes into every word.” –The Associated Press″Told with the intelligence, wit, and tragedy that have become hallmarks of the author’s work.... This is the story of us.” –Slate“Earnest and empathetic.” –The New York TimesTuberculosis has been entwined with hu­manity for millennia. Once romanticized as a malady of poets, today tuberculosis is seen as a disease of poverty that walks the trails of injustice and inequity we blazed for it.In 2019, author John Green met Henry Reider, a young tuberculosis patient at Lakka Government Hospital in Sierra Leone. John be­came fast friends with Henry, a boy with spindly legs and a big, goofy smile. In the years since that first visit to Lakka, Green has become a vocal advocate for increased access to treatment and wider awareness of the healthcare inequi­ties that allow this curable, preventable infec­tious disease to also be the deadliest, killing over a million people every year.In Everything Is Tuberculosis, John tells Henry’s story, woven through with the scientific and social histories of how tuberculosis has shaped our world—and how our choices will shape the future of tuberculosis.

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Book SynopsisTrade Review"A New Statesman Essential Non-Fiction Book of 2021""Winner of the PROSE Award in the History of Science, Medicine, and Technology, Association of American Publishers""A Choice Outstanding Academic Title of the Year""[A] superb new history of infectious disease. Be so grateful you live now!"---David Frum"Magisterial. . . . [Harper’s] mastery of the science is only matched by the ease of his prose. If I were to nominate a book of the year, it would be this one."---Andrew Sullivan, The Dishcast"[A] sweeping masterpiece. . . . It’s difficult for me to think of anyone who will not find something eye-opening and enlightening in the pages of this comprehensive, beautifully written and eloquent book." * Forbes *"Plagues upon the Earth is a remarkable achievement."---Talha Burki, The Lancet"This magnificent book stood out as much for its nuance and academic rigour as it did for its readability." * Inquisitive Biologist *"An ambitious, engaging, and unified history of humanity’s interaction with infectious disease."---Gregory J. Morgan, Science"By integrating history, demography, economics, evolutionary biology and genomics into a seamless narrative, [Harper] does something that I, for one, have never seen before done so eloquently or persuasively: he demonstrates that any thorough understanding of health requires the kind of sweeping perspective that the humanities offers."---Steve Mintz, Inside Higher Ed"Comprehensive."---Tyler Cowen, Marginal Revolution"A remarkable accomplishment that weaves together microbiology, history, and economics to understand the role of diseases in shaping human history. Harper, an established historian known for his first three books on Rome and late antiquity, has an impressive command of virology, bacteriology, and parasitology as well as history and economics. In 'Plagues Upon the Earth.' he explains all of these clearly and with many arresting turns of phrase and insights."---Alex Tabarrok, Marginal Revolution"Well-conceived. … [Kyle] Harper combs through the literature of history, economics, epidemiology, and other disciplines to deliver a solid study of the role of infectious disease in the human story. ... Harper’s long-view study is a welcome addition to the spate of recent books on epidemic disease." * Kirkus Reviews *"This is a solid book, superbly referenced and interdisciplinary, covering disease from pre-human origins to the present, and making extensive use of published DNA comparisons and descriptions of plagues by historical observers." * Choice *"Completing the reading of this book leaves one with more than a feeling of satisfaction. Admiration for a major task that was written in an engaging style that retains a facile elegance throughout its 700 pages, that presents comprehensive and detailed information as though it were the sort of material that readers come across every day, is what one might not expect, but welcomes, in a serious work of this size."---Ian Lipke, Queensland Reviewers Collective"This timely work is the book of extraordinary brilliance and scope and the most significant in the field since William McNeill’s Plagues and Peoples from the mid-1970s."---David Lorimer, Paradigm Explorer"Magisterial." * Prospect *"Plagues Upon the Earth is a highly provoking and enjoyable read. It shows that our success as a species is equally paralleled to the success of pathogens"---Makayla Alderson Fox, World History Encyclopedia

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Book SynopsisOffers an introduction to the modeling of infectious diseases in humans and animals. This book moves from modeling with simple differential equations to more complex models, where spatial structure, seasonal 'forcing', or stochasticity influence the dynamics, and where computer simulation needs to be used to generate theory.Trade Review"Matt Keeling and Pejman Rohani...have made important and original contributions to epidemiology...and are well qualified to deliver an authoritative, comprehensive and up-to-date review. [The authors] advocate...the use of mathematical models to help design disease-control programs. They recognize that modeling is a partnership between modelers and empiricists. For that reason, I hope that [readership] will extend beyond existing and new devotees of this challenging and exciting discipline."--Mark Woolhouse, Nature "This book represents a valuable step toward educating readers to have greater appreciation and understanding of the development of mathematical models in infectious diseases."--Carol Y. Lin, Biometrics Book Reviews "[T]he authors have created a well written and essential reference for epidemiologists, mathematicians and other scientists interested in the mathematical modeling of infectious diseases."--Michael Hohle, Biometrical JournalTable of ContentsAcknowledgments xiii Chapter 1: Introduction 1 1.1 Types of Disease 1 1.2 Characterization of Diseases 3 1.3 Control of Infectious Diseases 5 1.4 What Are Mathematical Models? 7 1.5 What Models Can Do 8 1.6 What Models Cannot Do 10 1.7 What Is a Good Model? 10 1.8 Layout of This Book 11 1.9 What Else Should You Know? 13 Chapter 2: Introduction to Simple Epidemic Models 15 2.1 Formulating the Deterministic SIR Model 16 2.1.1 The SIR Model Without Demography 19 2.1.1.1 The Threshold Phenomenon 19 2.1.1.2 Epidemic Burnout 21 2.1.1.3 Worked Example: Influenza in a Boarding School 26 2.1.2 The SIR Model With Demography 26 2.1.2.1 The Equilibrium State 28 2.1.2.2 Stability Properties 29 2.1.2.3 Oscillatory Dynamics 30 2.1.2.4 Mean Age at Infection 31 2.2 Infection-Induced Mortality and SI Models 34 2.2.1 Mortality Throughout Infection 34 2.2.1.1 Density-Dependent Transmission 35 2.2.1.2 Frequency Dependent Transmission 36 2.2.2 Mortality Late in Infection 37 2.2.3 Fatal Infections 38 2.3 Without Immunity: The SIS Model 39 2.4 Waning Immunity: The SIRS Model 40 2.5 Adding a Latent Period: The SEIR Model 41 2.6 Infections with a Carrier State 44 2.7 Discrete-Time Models 46 2.8 Parameterization 48 2.8.1 Estimating R0 from Reported Cases 50 2.8.2 Estimating R0 from Seroprevalence Data 51 2.8.3 Estimating Parameters in General 52 2.9 Summary 52 Chapter 3: Host Heterogeneities 54 3.1 Risk-Structure: Sexually Transmitted Infections 55 3.1.1 Modeling Risk Structure 57 3.1.1.1 High-Risk and Low-Risk Groups 57 3.1.1.2 Initial Dynamics 59 3.1.1.3 Equilibrium Prevalence 62 3.1.1.4 Targeted Control 63 3.1.1.5 Generalizing the Model 64 3.1.1.6 Parameterization 64 3.1.2 Two Applications of Risk Structure 69 3.1.2.1 Early Dynamics of HIV 71 3.1.2.2 Chlamydia Infections in Koalas 74 3.1.3 Other Types of Risk Structure 76 3.2 Age-Structure: Childhood Infections 77 3.2.1 Basic Methodology 78 3.2.1.1 Initial Dynamics 80 3.2.1.2 Equilibrium Prevalence 80 3.2.1.3 Control by Vaccination 81 3.2.1.3 Parameterization 82 3.2.2 Applications of Age Structure 84 3.2.2.1 Dynamics of Measles 84 3.2.2.2 Spread and Control of BSE 89 3.3 Dependence on Time Since Infection 93 3.3.1 SEIR and Multi-Compartment Models 94 3.3.2 Models with Memory 98 3.3.3 Application: SARS 100 3.4 Future Directions 102 3.5 Summary 103 Chapter 4: Multi-Pathogen/Multi-Host Models 105 4.1 Multiple Pathogens 106 4.1.1 Complete Cross-Immunity 107 4.1.1.1 Evolutionary Implications 109 4.1.2 No Cross-Immunity 112 4.1.2.1 Application: The Interaction of Measles and Whooping Cough 112 4.1.2.2 Application: Multiple Malaria Strains 115 4.1.3 Enhanced Susceptibility 116 4.1.4 Partial Cross-Immunity 118 4.1.4.1 Evolutionary Implications 120 4.1.4.2 Oscillations Driven by Cross-Immunity 122 4.1.5 A General Framework 125 4.2 Multiple Hosts 128 4.2.1 Shared Hosts 130 4.2.1.1 Application: Transmission of Foot-and-Mouth Disease 131 4.2.1.2 Application: Parapoxvirus and the Decline of the Red Squirrel 133 4.2.2 Vectored Transmission 135 4.2.2.1 Mosquito Vectors 136 4.2.2.2 Sessile Vectors 141 4.2.3 Zoonoses 143 4.2.3.1 Directly Transmitted Zoonoses 144 4.2.3.2 Vector-Borne Zoonoses: West Nile Virus 148 4.3 Future Directions 151 4.4 Summary 153 Chapter 5: Temporally Forced Models 155 5.1 Historical Background 155 5.1.1 Seasonality in Other Systems 158 5.2 Modeling Forcing in Childhood Infectious Diseases: Measles 159 5.2.1 Dynamical Consequences of Seasonality: Harmonic and Subharmonic Resonance 160 5.2.2 Mechanisms of Multi-Annual Cycles 163 5.2.3 Bifurcation Diagrams 164 5.2.4 Multiple Attractors and Their Basins 167 5.2.5 Which Forcing Function? 171 5.2.6 Dynamical Trasitions in Seasonally Forced Systems 178 5.3 Seasonality in Other Diseases 181 5.3.1 Other Childhood Infections 181 5.3.2 Seasonality in Wildlife Populations 183 5.3.2.1 Seasonal Births 183 5.3.2.2 Application: Rabbit Hemorrhagic Disease 185 5.4 Summary 187 Chapter 6: Stochastic Dynamics 190 6.1 Observational Noise 193 6.2 Process Noise 193 6.2.1 Constant Noise 195 6.2.2 Scaled Noise 197 6.2.3 Random Parameters 198 6.2.4 Summary 199 6.2.4.1 Contrasting Types of Noise 199 6.2.4.2 Advantages and Disadvantages 200 6.3 Event-Driven Approaches 200 6.3.1 Basic Methodology 201 6.3.1.1 The SIS Model 202 6.3.2 The General Approach 203 6.3.2.1 Simulation Time 203 6.3.3 Stochastic Extinctions and The Critical Community Size 205 6.3.3.1 The Importance of Imports 209 6.3.3.2 Measures of Persistence 212 6.3.3.3 Vaccination in a Stochastic Environment 213 6.3.4 Application: Porcine Reproductive and Respiratory Syndrome 214 6.3.5 Individual-Based Models 217 6.4 Parameterization of Stochastic Models 219 6.5 Interaction of Noise with Heterogeneities 219 6.5.1 Temporal Forcing 219 6.5.2 Risk Structure 220 6.5.3 Spatial Structure 221 6.6 Analytical Methods 222 6.6.1 Fokker-Plank Equations 222 6.6.2 Master Equations 223 6.6.3 Moment Equations 227 6.7 Future Directions 230 6.8 Summary 230 Chapter 7: Spatial Models 232 7.1 Concepts 233 7.1.1 Heterogeneity 233 7.1.2 Interaction 235 7.1.3 Isolation 236 7.1.4 Localized Extinction 236 7.1.5 Scale 236 7.2 Metapopulations 237 7.2.1 Types of Interaction 240 7.2.1.1 Plants 240 7.2.1.2 Animals 241 7.2.1.3 Humans 242 7.2.1.4 Commuter Approximations 243 7.2.2 Coupling and Synchrony 245 7.2.3 Extinction and Rescue Effects 246 7.2.4 Levins-Type Metapopulations 250 7.2.5 Application to the Spread of Wildlife Infections 251 7.2.5.1 Phocine Distemper Virus 252 7.2.5.2 Rabies in Raccoons 252 7.3 Lattice-Based Models 255 7.3.1 Coupled Lattice Models 255 7.3.2 Cellular Automata 257 7.3.2.1 The Contact Process 258 7.3.2.2 The Forest-Fire Model 259 7.3.2.3 Application: Power laws in Childhood Epidemic Data 260 7.4 Continuous-Space Continuous-Population Models 262 7.4.1 Reaction-Diffusion Equations 262 7.4.2 Integro-Differential Equations 265 7.5 Individual-Based Models 268 7.5.1 Application: Spatial Spread of Citrus Tristeza Virus 269 7.5.2 Applilcation: Spread of Foot-and-mouth Disease in the United Kingdom 274 7.6 Networks 276 7.6.1 Network Types 277 7.6.1.1 Random Networks 277 7.6.1.2 Lattices 277 7.6.1.3 Small World Networks 279 7.6.1.4 Spatial Networks 279 7.6.1.5 Scale-Free Networks 279 7.6.2 Simulation of Epidemics on Networks 280 7.7 Which Model to Use? 282 7.8 Approximations 283 7.8.1 Pair-Wise Models for Networks 283 7.8.2 Pair-Wise Models for Spatial Processes 286 7.9 Future Directions 287 7.10 Summary 288 Chapter 8: Controlling Infectious Diseases 291 8.1 Vaccination 292 8.1.1 Pediatric Vaccination 292 8.1.2 Wildlife Vaccination 296 8.1.3 Random Mass Vaccination 297 8.1.4 Imperfect Vaccines and Boosting 298 8.1.5 Pulse Vaccination 301 8.1.6 Age-Structured Vaccination 303 8.1.6.1 Application: Rubella Vaccination 304 8.1.7 Targeted Vaccination 306 8.2 Contact Tracing and Isolation 308 8.2.1 Simple Isolation 309 8.2.2 Contact Tracing to Find Infection 312 8.3 Case Study: Smallpox, Contact Tracing, and Isolation 313 8.4 Case Study: Foot-and-Mouth Disease, Spatial Spread, and Local Control 321 8.5 Case Study: Swine Fever Virus, Seasonal Dynamics, and Pulsed Control 327 8.5.1 Equilibrium Properties 329 8.5.2 Dynamical Properties 331 8.6 Future Directions 333 8.7 Summary 334 References 337 Index 361 Parameter Glossary 367

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Book SynopsisInfection: Microbiology and Management provides a core resource for the understanding of medical microbiology and infectious diseases. Content covers microbiological and clinical diagnosis, through to clinical management, epidemiology and the control of infectious conditions as they occur both in the hospital and community setting. With a concise, systems-based approach, the third edition has been revised and restructured and now covers wider epidemiological and public concerns. Key feature boxes, self assessment and case studies assist learning in each chapter. Designed to be used either as a basic learning text, or as a practical textbook in the clinical setting, Infection: Microbiology and Management, previously titled Infectious Disease, will continue to appeal to students at all stages of their career, candidates for higher examinations, the general physician and surgeon, epidemiologists and experts in public health.Trade Review"This book explains the nature, diagnosis and management of infection in a more comprehensive manner than standard clinical textbooks. It makes good links between pathology and clinical features...if you are thinking about buying a microbiology textbook, this is one of the better ones. It doesn't skimp on detail but still keeps your attention. Considering the amount of microbiology in exams, I would recommend a thorough one, like this." Northwing, Sheffield Medical Student's MagazineTable of ContentsPart 1: Infection, Pathogens and Antimicrobial Agents. 1 The Nature and Pathogenesis of Infection. 2 Structure and Classification of Pathogens. 3 Laboratory Techniques in the Diagnosis of Infection. 4 Antimicrobial Chemotherapy. Part 2: Systematic Infectious Diseases. 5 Infections with Skin, Mucosal and Soft-tissue Disorders. 6 Upper Respiratory Tract Infections. 7 Lower Respiratory Tract Infections. 8 Gastrointestinal Infections and Food Poisoning. 9 Infections of the Liver. 10 Infections of the Urinary Tract. 11 Childhood Infections. 12 Infections of the Cardiovascular System. 13 Infections of the Central Nervous System. 14 Bone and Joint Infections. Part 3: Genital, Sexually Transmitted and Birth-Related Infections. 15 Genital and Sexually Transmitted Diseases. 16 HIV Infection and Retroviral Diseases. 17 Congenital and Perinatal Infections. Part 4: Disorders Affecting More than One System. 18 Tuberculosis and Other Mycobacterial Diseases. 19 Bacteraemia and Sepsis. 20 Pyrexia of Unknown Origin. 21 Post-infectious Disorders. Part 5: Special Hosts, Environments and the Community. 22 Infections in Immunocompromised Patients. 23 Hospital Infections. 24 Travel-associated and Exotic Infections. 25 Control of Infection in the Community. 26 Emerging and Re-emerging Infections. Index

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Book SynopsisWilliam H. Foege, one of the most respected leaders in global public health, takes readers on a tour of his time at the CDC. In its seventy years, the Centers for Disease Control and Prevention (CDC) has evolved from a malaria control program to an institution dedicated to improving health for all people across the world. The Fears of the Rich, The Needs of the Poor is a revealing account of the CDC's development by its former director, public health luminary William H. Foege. Dr. Foege tells the stories of pivotal moments in public health, including the eradication of smallpox (made possible due in part to Foege's research) and the discovery of Legionnaires' disease, Reye syndrome, toxic shock syndrome, and HIV/AIDS. With good humor and optimism, he recounts the various crises he surmounted, from threats of terrorist attacks to contentious congressional hearings and funding cuts. Highlighting the people who made possible some of public health's biggest successes, Foege outlines thTrade ReviewI would recommend the book to anyone interested in, or who works within, the field of public health. It is an excellent book that can be included on reading lists for public/global health modules.—Andrew Southgate, Canterbury Christ Church University, Nursing TimesThis insider's history of the politics, health processes, and management issues involved in maintaining and expanding the CDC's influence around the world should be required reading for anyone interested in public health on a global scale.—Donovan's Literary ServicesBy sharing real stories of infectious diseases that devastated populations and how Foege and his colleagues grew into the leaders that helped bring these epidemics under control, the book provides guidance and inspiration for current and future public health workforces. Although public health can be a thankless profession, through this memoir Foege reminds us how indispensable the field is for our world's future.—Emerging Infectious DiseasesBeautiful, wonderful, clear encouraging book—Anna Maria PolidoriTable of ContentsPreface1. A Threat2. Security3. Lassa and Ebola4. A Short History of the CDC5. The Fears of the Rich and the Needs of the Poor6. Balancing Babies and the Marketplace7. Toxic Shock8. Serendipity and Unexpected Paths9. The Mysterious Deaths of Veterans10. An Unexpected Return to the CDC11. Disaster Relief12. Smallpox Claims Its Last Victims13. Coming into the United States14. Organizing for Success15. Vaccines16. Do No Harm17. Global Health18. Positive Politics19. Toxic Politics20. Reye Syndrome21. Comic Relief22. Reducing the Toll of Injuries23. Uncommon People24. AIDS25. Blind Spots26. On Budgets and BurglarsAcknowledgmentsAppendixReferencesIndex

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Book SynopsisProvides trustworthy guidance on pediatric infectious disease prevention, management, and control. The 33rd edition continues this tradition of excellence with the latest clinical guidance on the manifestations, etiology, epidemiology, diagnosis and treatment of more than 200 childhood infectious diseases.

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Book SynopsisNicole Charles frames the refusal of Afro-Barbadians to immunize their daughters with the HPV vaccine as suspicion, showing that this suspicion is based in concrete histories of government mistrust and coercive medical practices on colonized peoples.Trade Review“Suspicion is a compellingly written and superlatively theorized ethnography of public health, affect, and the persistence of racism in the Caribbean. Nicole Charles uses suspicion to understand the logic behind Black parents' decisions about whether to give their children vaccines, showing that their decisions are rooted not in ignorance and irrationality but within long histories of racial and sexual injury as well as hierarchies related to race, class, color, education, and authority. This is quite simply a remarkable book.” -- Deborah A. Thomas, author of * Political Life in the Wake of the Plantation: Sovereignty, Witnessing, Repair *“In this empirically rich account of HPV vaccine promotion and refusal in Barbados, Nicole Charles depathologizes and unsettles conventional understandings of vaccine hesitancy through the urgent conceptual framework of suspicion. Deeply informed by and contributing to plural interdisciplinary conversations in Black feminisms, transnational gender studies, science and technology studies, and the history and anthropology of the Caribbean, Charles listens closely to insightful interlocutors in Barbados to illuminate the embodied affective intensity of contemporary vaccine politics.” -- Anne Pollock, author of * Synthesizing Hope: Matter, Knowledge, and Place in South African Drug Discovery *"Charles provides us with a thoroughly researched examination of an important subject at a time when such research is urgently needed in the face of a deadly pandemic. She shows us that parents in Barbados are motivated by genuine fears regarding the health of their children, and reasonable suspicion about the motivations of the state, and of vaccine manufacturers. That is significant for understanding how black Caribbean people evaluate technologies that affect health." -- F.S.J. Ledgister * Caribbean Quarterly *"This interesting, theoretically engaging book explores vaccine hesitancy among adolescents and young women in the English-speaking Caribbean nation of Barbados. Feminist scholars, medical anthropologists, and health-care professionals in the Caribbean and other postcolonial settings will benefit greatly from exposure to the ideas outlined in this book. Highly recommended. Lower- and upper-division undergraduates. Graduate students, faculty, and professionals. General readers." -- F. H. Smith * Choice *“Suspicion is a richly documented and theoretically ambitious ethnography of HPV vaccination hesitancy in Barbados. . . . Charles persuasively shows that Barbadians’ suspicion toward the HPV vaccination should be taken seriously, as it constitutes a productive tool for social and cultural analysis. . . . [Suspicion] is a theoretically sophisticated book that charts new territory within the literature.” -- Cristina A. Pop * Gender & Society *“This remarkable book . . . makes an important contribution to international scholarship on vaccine hesitancy, linking personal and familial decision-making in Barbados with transnational economic trends, national health and economic policies, and local embodied experiences of postcoloniality. . . . Suspicion offers a necessary correction to current received wisdom about some people’s deeply felt discomfort about vaccines, which inevitably links vaccine hesitancy with irrationality and misinformation.” -- Bernice L. Hausman * Journal of Medical Humanities *“Although numerous studies have been undertaken on vaccine confidence and its social regulators, there has rarely been a work published in this area that provides such depth of feeling to the voiced concerns of a specific community. . . . The result is a beautifully rich understanding of the complexity of human decision-making and a recognition that, at least in the case of Afro-Barbadians, ‘suspicion’ is a far more apt description of collective vaccine response than ‘hesitancy.’” -- Paula Larsson * H-Sci-Med-Tech, H-Net Reviews *Table of ContentsAcknowledgments ix Suspicion: An Introduction 1 1. Circles of Suspicion 24 2. Risk and Suspicion: An Archive of Surveillance and Racialized Biopolitics in Barbados 45 3. (Hyper)Sexuality, Respectability, and the Language of Suspicion 66 4. Care, Embodiment, and Sensed Protection 94 5. Suspicion and Certainty 115 Conclusion: Toward Radical Care 148 Notes 155 Bibliography 175 Index 191

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Book Synopsis**THE SUNDAY TIMES BESTSELLER**'Brilliant! It's hard to change your life - but this book gives you all the reasons it's possible. From the first page to the last, one revelation after another.'JEREMY VINE'Brilliant . . . especially required reading in these COVID-19 days'LIZ EARLE'Metabolism, inflammation, and immunity are three sides of the same coin. Fix one and you fix them all. Dr Aseem Malhotra offers you a way to fix all three at once, and the solution is as easy as your fork.' PROFESSOR ROBERT LUSTIG, bestselling author of Fat Chance'This remarkable book will change your life. Beautifully written, it compiles in one place the health messages we all know make sense. PROFESSOR KAROL SIKORA, leading cancer specialist and Founding Dean, University of Buckingham Medical School'Read this book and follow the plan, it may save your life.' GURINDER CHADHA, OBE, director of Bend It Like Beckham'A crystal-clear roadmap to reverse the roots causes of our poor metabolic and immune health. It is the handbook of health for our time.' MARK HYMAN, New York Times bestselling author of Food Fix*******The simple, evidence-based diet plan to rapidly improve your metabolic health, help with normal immune function and likely reduce the risk of severe effects from Covid-19.Dr Aseem Malhotra is a leading NHS-trained cardiologist and a pioneer of lifestyle medicine. He has been at the forefront of citing the health conditions which make us vulnerable to the worst effects of Covid-19. Obesity, Type 2 diabetes and heart disease are high among them - and all indicators of poor metabolic health. The good news is that in just 21 days we can prevent, improve and even potentially reverse many of the underlying risk factors that exacerbate how infections, including Covid-19, affect us and improve our ability to recover from them. Giving us the evidence-based science behind the plan, Dr Malhotra shares how simple changes to our diet as well as daily exercise and stress relief can have remarkable results in improving our markers for metabolic health, even helping to put Type 2 diabetes into remission, reduce risk factors for heart disease, decrease weight and enhance vitality.Arguing for the huge benefits to global health of these highly effective lifestyle changes, he shows how just 21 days can help us to start the journey to lead a healthier and longer life.Trade Review'This valuable and timely book is a must read.' -- KIM PEARSON, Harley Street nutritionist * London Evening Standard *'You have to get immediately The 21 Day immunity plan and take action now.' * European Scientist *'Dr Aseem Malhotra is a quite remarkable man . . . his timely, evidence-based and brilliant new 21-day immunity plan is a perfect way to take the first step to transforming your life. I wish you well on your journey to better health.' -- From the Foreword by TOM WATSON'I've been unfortunate enough to have had #COVID19. I feel had I not focused on regaining my metabolic health and sending my type 2 diabetes into remission things could have been much worse. This amazing Doctor puts his head above the parapet. I have great respect for Dr Aseem Malhotra and owe my regained metabolic health to him.' -- DEBRA SCOTT, retired civil servant'Feel good today and increase your chance of living a longer and healthier life. In this well researched book Dr Malhotra provides the science and the steps for this double win.' -- DR CAMPBELL MURDOCH, Clinical Adviser, Royal College of GPs'This game-changing book is a must-read for anyone wishing to understand the link between metabolic health and immunity.' -- DR RAVI KUMAR KAMEPALLI, Board-Certified in Infectious Diseases, Wound Care and Obesity Medicine, Augusta, USA'Dr Aseem Malhotra spells it all out right here in front of you, with a perfect combination of smart, simple strategies for prevention or management of lifestyle conditions and keeping the immune system in best shape.' -- DR CARYN ZINN, Senior Lecturer, Dietitian, AUT University, Head of Research – School of Support and Recreation, Auckland, New Zealand'This groundbreaking book empowers the reader with knowledge of the practical steps we can all take to improve our health status and protect ourselves against diseases of all kinds.' -- KIM PEARSON, Harley Street nutritionist'Brilliant . . . especially required reading in these COVID-19 days' -- Liz Earle

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Book SynopsisTrade Review"The authors make a passionate case for the link between climate change and emerging infectious diseases. These are two of the biggest threats facing humanity and in combination the risks are escalated even further. Raising awareness of this combined threat is an original, timely, and vital contribution. I am not aware of another book on this topic that comes close to this in terms of the breadth and depth of its ambition."--Ian Goldin, Professor of Globalisation and Development, University of Oxford "The Stockholm Paradigm provides a new perspective on how we should think about (and combat) emerging pathogens. The authors, all highly respected parasitologists, are well qualified to provide the historical context, broad synthesis, and contemporary urgency required for a shift in thinking, essentially away from reactive, for profit programs. A game changer for parasitology and public health efforts focused on emerging infectious diseases."--Joseph A. Cook, Professor of Biology, Curator of the Division of Mammals at the Museum of Southwestern Biology, University of New Mexico

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Book SynopsisWhy the news about the global decline of infectious diseases is not all good.Plagues and parasites have played a central role in world affairs, shaping the evolution of the modern state, the growth of cities, and the disparate fortunes of national economies. This book tells that story, but it is not about the resurgence of pestilence. It is the story of its decline. For the first time in recorded history, virus, bacteria, and other infectious diseases are not the leading cause of death or disability in any region of the world. People are living longer, and fewer mothers are giving birth to many children in the hopes that some might survive. And yet, the news is not all good. Recent reductions in infectious disease have not been accompanied by the same improvements in income, job opportunities, and governance that occurred with these changes in wealthier countries decades ago. There have also been unintended consequences. In this book, Thomas Bollyky explores the paradox in ou

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Book SynopsisUnderstanding Public Health is an innovative series published by Open University Press in collaboration with the London School of Hygiene & Tropical Medicine, where it is used as a key learning resource for postgraduate programmes. It provides self-directed learning covering the major issues in public health affecting low-, middle- and high-income countries.Communicable diseases are ever present in the world today. Social and economic issues like poverty, access to essential vaccinations and lack of substantive healthcare systems contribute to mortality rates alongside epidemiological factors like portals of entry and bacterial sources.This public health textbook, in exploring the causes and conditions of communicable diseases like ebola and malaria, clearly outlines communicable disease control and prevention measures as well as how to apply these measures effectively in different contexts and populations Table of ContentsSection 1: Understanding communicable diseaseChapter 1: A brief history of the development of communicable disease control Chapter 2: Concepts in communicable disease causation Chapter 3: The chain of infection and modes of transmissionSection 2: Measures to control communicable diseasesChapter 4: Surveillance Chapter 5: Vaccination Chapter 6: Prevention Chapter 7: Outbreak response Section 3: Application of measures to control communicable diseasesChapter 8 – Communication Chapter 9: Ethics and communicable disease control Chapter 10: Health systems and communicable disease control Chapter 11: Emerging trends, challenges and opportunities in communicable disease control  

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Book SynopsisLeading researchers discuss key aspects of the biology of Salmonella enterica infections in this broad-ranging book. It will equip the reader with detailed and up-to-date knowledge of S. enterica, giving an integrated view of clinical, molecular and immunological aspects of these infections.Trade Review'Whether your interests lie in human or animal infection, in the virulence factors that make Salmonella such a successful pathogen, or even in the ability of Salmonella to be used for the immunotherapy of cancer, this book should prove a useful addition to bookshelves in libraries and research labs.' Jay Hinton, Institute of Food ResearchTable of Contents1. Epidemiological and clinical aspects of human typhoid fever Christopher M. Parry; 2. Antibiotic resistance in Salmonella infections Fiona J. Cooke and John Wain; 3. Host-specificity of Salmonella infections in animal species Timothy S. Wallis; 4. Public health aspects of Salmonella enterica in food production Tom Humphrey; 5. The Salmonella genome: a global view Anne L. Bishop, Gordon Dougan and Stephen Baker; 6. Pathogenicity islands and virulence of Salmonella enterica Michael Hensel; 7. In vivo identification, expression and function of Salmonella virulence genes Helen Andrews-Polymenis, Caleb W. Dorsey, Manuela Raffatellu and Andreas J. Bäumler; 8. Mechanisms of immunity to Salmonella infections Pietro Mastroeni; 9. Interactions of Salmonella enterica with phagocytic cells Bruce D. McCollister and Andres Vazquez-Torres; 10. Interactions between Salmonella and dendritic cells: what happens along the way? Cecilia Johansson, Malin Sundquist and Mary Jo Wick; 11. Immunity to Salmonella in domestic (food animal) species Paul Wigley, Paul Barrow and Bernardo Villarreal-Ramos; 12. Newer vaccines against typhoid fever and gastrointestinal Salmonelloses Richard A. Strugnell and Odilia L. C. Wijburg; 13. Salmonella enterica-based antigen delivery systems José A. Chabalgoity.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book Synopsis'Manaugh and Twilley shed illuminating light on a phenomenon that seems utterly of the present moment.' Financial Times’ Best Books of the Year'Startlingly timely, authoritatively researched, and electrifyingly written.' Steve Silberman, author of NeuroTribes: The Legacy of Autism and the Future of NeurodiversityQuarantine has shaped our world, yet it remains both feared and misunderstood. It is our most powerful response to uncertainty, but it operates through an assumption of guilt: in quarantine, we are considered infectious until proven safe. An unusually poetic metaphor for moral and mythic ills, quarantine means waiting to see if something hidden inside of us will be revealed. Until Proven Safe tracks the history and future of quarantine around the globe, chasing the story of emergency isolation through time and space – from the crumbling lazarettos of the Mediterranean to the hallways of the CDC, to the corporate giants hoping to disrupt the widespread quarantine imposed by Covid-19 before the next pandemic hits through surveillance and algorithmic prediction.Yet quarantine is more than just a medical tool: Geoff Manaugh and Nicola Twilley drop deep into the Earth to tour a nuclear-waste isolation facility beneath the New Mexican desert, strip down to nothing but protective Tyvek suits to see plants stricken with a disease that threatens the world’s wheat supply, and meet NASA’s Planetary Protection Officer tasked with saving the Earth from extraterrestrial infections. The result is part travelogue, part intellectual history – a book as compelling as it is definitive, and one that could not be more urgent or timely.Trade ReviewReads like a global safari of humanity’s best-laid plans being never quite enough . . . [Manaugh and Twilley] are well-placed to tell the tale, weaving the spatial, social and scientific facets of medical isolation into an entertaining adventure. -- Oliver Wainwright * Guardian *Until Proven Safe is not all doom and gloom, though: there are plenty of QI-style facts in this wide-ranging and colourful survey. -- Christopher Hart * Sunday Times *Brainy but accessible -- Mark Honigsbaum * Observer *A timely intellectual history of quarantine . . . As Manaugh and Twilley write, quarantine is enforced in cases of potential infection, of possible risk, and ­therefore admits a degree of uncertainty. One of the striking continuities in their history is how this uncertainty has been exploited to deepen gendered and racialised inequalities. -- Erin Maglaque * New Statesman *Until Proven Safe, by Geoff Manaugh and Nicola Twilley, dives into the crudely effective and widely abused strategy of quarantine, the separation of those feared to be sick from those deemed healthy. -- Ian Sample * Guardian Best Science Books of the Year *Manaugh and Twilley shed illuminating light on a phenomenon that seems utterly of the present moment. * Financial Times’ Best Books of the Year *A compelling case that we must continue to refine the use of quarantine, balancing the needs of public health with those of human rights. * New Yorker *[Manaugh and Twilley] bring an impressively wide range of interests to bear on a subject that involves not only infectious disease but also - in their ambitious yet seamless narration - politics, agriculture, surveillance and even outer space. -- Jennifer Szalai * New York Times Book Review *What makes [Until Proven Safe] compelling, besides [Manaugh and Twilley’s] extensive experience as journalists, is the depth of their research coupled with a firm conviction that quarantine, a mighty yet dangerous weapon, must be used ‘more wisely in the future’ . . . This is an exceptionally powerful book -- A. Roger Ekirch * Wall Street Journal *Until Proven Safe is uncanny in its prescience . . . Twilley and Manaugh see things that others don’t. Their insatiable curiosity reveals itself through all of their endeavors -- Allison Arieff * San Francisco Chronicle *Manaugh’s and Twilley’s extensive history of a concept we might otherwise take for granted is actually the perfect postpandemic read - an imaginative, layperson-friendly way to make sense of and contextualize what we just lived through. -- Arianna Rebolini * BuzzFeed *Quarantine provides a buffer and a delay, offering space and time, between the known (healthy folks) and the dangerous (potentially contagious people). Its complicated nature is adeptly explored, including ethical concerns, legal and moral questions, and enforcement challenges . . . Fascinating reading. -- Tony Miksanek * Booklist *A riveting and timely look at how humanity has protected itself by isolating segments of its populations. . . Manaugh and Twilley cull their research into a concise and logical series of recommendations for future public health crises, grounded in a deep appreciation of the human impact of quarantining. * Publishers Weekly *Captivating . . . Manaugh and Twilley meld a global view of a timely subject with vividly detailed accounts . . . But a larger charm of this smart book lies in their ability to bring potentially dry topics to life . . . An infectiously appealing overview of efforts to contain the potentially infectious. * Kirkus Reviews *Until Proven Safe combines history, geography, epidemiology, and the ethics of space exploration – how can this be – Because, as the authors explain in a very entertaining and wide-ranging way, quarantine, ironically enough, crosses borders of space and time to make a complex knot of stories. Timely, eye-opening, provocative – you will see the world differently after reading it. -- Kim Stanley Robinson, author of Ministry for the FutureWhat does it mean to isolate threats: people carrying diseases; the microbes, themselves; radioactive materials? For centuries the primary tool of isolation has been quarantine, and in this globe-trotting tale of history and today’s COVID-19 crisis, Geoff Manaugh and Nicola Twilley offer answers that will make your jaw drop. Nothing about "quarantine" is as simple or straight-forward as you think. -- Laurie Garrett, author of The Coming Plague: Newly Emerging Diseases in a World out of BalanceAn engrossing study of the ways in which quarantines have changed social, emotional, and political life over hundreds of years, and a fascinating exploration of the perennial roles of fear, conspiracy theories, greed, and prejudice, to which we now add the threat of permanent digital surveillance in the name of public health. Perfect for our time and guidance for the future. -- Ellen Ullman, author of Close to the Machine and Life in CodeAs Twilley and Manaugh reveal in this timely but timeless, ambitious and flawlessly executed account, quarantines have shaped our history . . . The struggle to protect ourselves from invisible and deadly contagions is waged daily and largely out of sight - along borders and spore superhighways, in biosecure piggeries and nuclear waste facilities a half-mile underground. Quarantine: boring to live through, unbelievably interesting to read about. -- Mary Roach, author of Stiff and GruntUntil Proven Safe is the book of our historical moment - a provocative meditation on how society uses quarantine to define the boundaries of self and other when faced with the terrifying unknown. Startlingly timely, authoritatively researched, and electrifyingly written. -- Steve Silberman, author of NeuroTribes: The Legacy of Autism and the Future of NeurodiversityStrap on your plague beaks and round up the loose women! In this intrepid, occasionally creepy jaunt through seven centuries of disease control, Twilley and Manaugh prove that the past is never dead; it’s just in quarantine. -- Alexis Coe, author of You Never Forget Your First: A Biography of George Washington

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