Genetics (non-medical) Books

Book SynopsisYou can change your genes - and this revelatory, cutting-edge popular science book will explain how.Trade ReviewFascinating and Highly accessible. * Sunday Times *Sharon Moalem peels away at the complex discussion of nature and nurture. * Dan Ariely, bestselling author of Predictably Irrational *In his new book, Moalem describes riveting dramas emerging from both defective genes and reparative epigenetics...fascinating. * The New York Times Book Review *Dr. Moalem is an eloquent guide through the astonishing new world of genetic discovery - with all its implications for both personal health and public policy. If you've wondered about the impact of genetics on your life- read this book! * Kinney Zalesne, New York Times bestselling author of Microtrends *

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Book SynopsisThe fourth edition of this popular textbook retains its focus on the fundamental principles of gene manipulation, providing an accessible and broad-based introduction to the subject for beginning undergraduate students. It has been brought thoroughly up to date with new chapters on the story of DNA and genome editing, and new sections on bioethics, significant developments in sequencing technology and structural, functional and comparative genomics and proteomics, and the impact of transgenic plants. In addition to chapter summaries, learning objectives, concept maps, glossary and key word lists the book now also features new concluding sections, further reading lists and web-search activities for each chapter to provide a comprehensive suite of learning resources to help students develop a flexible and critical approach to the study of genetic engineering.Trade Review'Genetic engineering represents a toolbox that all students within the basic and applied biology fields must get acquainted with. The fourth edition of An Introduction to Genetic Engineering is an excellent up-to-date version of a classic textbook. This ambitious book excellently balances the molecular biology knowledge required to grasp the comprehensive gene technology toolbox with a discussion of its impact on society.' Per Amstrup Pedersen, University of Copenhagen'As a biomedical engineering professor teaching an undergraduate Genetic Engineering course for close to 10 years, I use Dr Nicholl's An Introduction to Genetic Engineering as my go-to textbook. It is not one of those overly thick textbooks that overwhelm students. Its comprehensiveness captures readers' attention with succinct fundamental concepts that truly promote one's interest in exploring the wonder of many genetic engineering techniques and applications. To facilitate that further, the material provided at the end of each chapter encourages readers to expand their learning with relevant resources … Many of my students become so interested that they pursue graduate degrees and have a career in this field. Dr Nicholl's textbook has a long-term influence on its readers.' M. Ete Chan, State University of New York at Stony Brook'Dr Nicholl's book covers all the basic material that one would expect from its title, but what particularly impressed me was how it isn't afraid to move into political and socio-economic arenas. In Chapter 16, for example, balanced arguments are presented for and against the development of transgenic organisms, and these don't always come out in favour of the science.' Neil Crickmore, University of SussexTable of ContentsPreface; Part I. Genetic Engineering in Context: 1. Introduction; 2. The story of DNA; 3. Brave new world or genetic nightmare?; Part II. The Basis of Genetic Engineering: 4. Introducing molecular biology; 5. The tools of the trade; 6. Working with nucleic acids; Part III. The Methodology of Gene Manipulation: 7. Host cells and vectors; 8. Cloning strategies; 9. The polymerase chain reaction; 10. Selection, screening and analysis of recombinants; 11. Bioinformatics; 12. Genome editing; Part IV. Genetic Engineering in Action: 13. Investigating genes, genomes and 'otheromes'; 14. Genetic engineering and biotechnology; 15. Medical and forensic applications of gene manipulation; 16. Transgenic plants and animals; 17. The other sort of cloning; Glossary; Index.

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Book SynopsisThe second book in Kereen Getten's action-packed mystery series for younger readers! Fayson has been dreaming of going back to the island ever since she left. But no sooner is she reunited with Di Island Crew than a mysterious case comes their way - a haunted wardrobe that keeps making a spine-chilling sound! And to make matters worse, the crew have all received a letter threatening to reveal their deepest secrets. With the clock ticking, Fayson must rally her friends and take charge of the detective agency to solve the eerie mystery. But with tensions rising and friendship squabbles getting in the way, can they work together to crack the case and keep their secrets safe? __________ READERS ARE LOVING Di ISLAND CREW: 'So much fun' 'I really enjoyed this mystery story and read it from start to finish in one sitting' 'A fun adventure with just the right amount of fear and peril... I'll definitely be keeping an eye out for the rest of the series' 'Great characters, brilliantly paced and a big fat recommendation from my daughter'Trade Review'- - Praise for Di Island Crew Investigates series:' - -'Like Enid Blyton with a social conscience, this marks the start of an addictive new series for 8+' - Guardian'A charming plot... ideal for confident younger readers' - Booktrust'Exploring themes of family and friendship, this is great for fans of mystery adventure stories' - The Week Junior, Book of the Week''Absolutely excellent' - Fleur Hitchcock

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Book SynopsisTrade Review"A New Statesman Best Book of the Academic Presses""A highly original and very persuasive book. . . .Carefully argued and fair-minded but forceful in its conclusions, Free Agents is interdisciplinary research at its best."---Joe Humphreys, Irish Times"Mitchell's compelling and absorbing book acts both as a synthesizing primer about evolution and a powerful argument for free will. Its importance and quality are undeniable. A bold, brilliant must-read that should reach a large audience." * Kirkus Reviews, starred review *"An eloquent defense of our common-sense understanding of the mind. . . . [E]xcellent."---Andrew Crumey, Wall Street Journal"[Mitchell] makes a powerful case that history of life, in all its complex grandeur, cannot be appreciated until we understand the evolution of agency—and then, in creatures of sufficient complexity, the evolution of conscious free will. . . . [Free Agents] builds an argument that is methodical and crisp, and cuts through years of disputation like a knife through cotton candy."---James Gleick, New York Review of Books"Provocative." * Publishers Weekly *"Mitchell’s naturalization of free will shows that it need not be some mysterious non-physical force, but instead a cognitive phenomenon in which all manner of influences. . .are integrated into decisions to act, formulated with varying degrees of conscious awareness (of genuine will, you might say). “You” don’t generate free will; rather, the mental processes of deliberation are a part of what makes you."---Philip Ball, Times Literary Supplement"Humans are not, says Kevin Mitchell, the playthings of predestination. Millennia of evolution means that our nervous systems have given us the wherewithal both to imagine and to predict. Mitchell explains how this power came about and why it matters." * New Statesman *"Two popular books. . . have breathed new life into the ancient debate over whether we have free will. In Free Agents, Kevin Mitchell argues that we do, and in Determined, Robert Sapolsky argues that we don’t. To be blunt, on the big issue at hand – Mitchell is right and Sapolsky is wrong. . . . [H]ow can the information in our brains come together to form a coherent and causally potent self? Mitchell offers a strikingly lucid evolutionary story of how such a self emerged. "---Oliver Waters, Three Quarks Daily"Mitchell persuasively develops a more modest conception of free will that entails the evolved ability to make real choices in the service of our goals—that is, to act for our own reasons. This carefully argued, information-dense book will put a dent in any intellectual predilection toward determinism that some readers may have. It certainly did mine."---Ronald Bailey, Reason"A challenge to neuro-reductionism. . . . As Mitchell explains the growth of agency across 12 penetrating and fluent chapters, they read not like a series of academic lectures but rather a stimulating conversation where a reader’s next question is anticipated and answered."---Peter Sterling, Current Biology"A sophisticated, scientific response to determinism. . . . [A] provocative and special contribution to the discourse on free will."---Stetson Thacker, Holodoxa"Ground-breaking. . . .A significant contribution to the free will debate." * Paradigm Explorer *"Mitchell’s retelling of life’s history turns out to be a fascinating exercise with relevance far beyond the free will debate. . . . Free Agents is a tightly argued and compelling case in favour of free will. Mitchell proves himself an able wordsmith who crams profound ideas in short sentences that benefit from reading and unpacking slowly. . . . [A] spectacular read."---Leon Vlieger, Inquisitive Biologist

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Book SynopsisPresents the principles of genetics - classical and modern - in a cartoon format. Anecdotes about how the ancients tried to explain sex determination and inheritance abound, making the learning of the concepts of Mendel's Laws, mutations, DNA and gene splicing easier to understand.

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Book SynopsisTable of Contents1. Introduction: The challenge of genomic DNA interpretation Section I. Theoretical Chapters 2. General considerations: Terminology and standards 3. International consensus guidelines for constitutional sequence variant interpretation 4. Quantitative modelling: Multifactorial integration of data 5. Clinical and genetic evidence and population evidence 6. The computational approach to variant interpretation: principles, results, and applicability 7. Functional evidence (I) transcripts and RNA splicing outline 8. Functional evidence (II) protein and enzyme function 9. Somatic data usage for classification of germline variants 10. Pharmacogenomics and personalized medicine 11. Data sharing and gene variant databases 12. Approaches to the comprehensive interpretation of genome-scale sequencing 13. Phenotype evaluation and clinical context: Application of case-level data in genomic variant interpretation Section II. Practical Chapters 14. Inherited cardiomyopathies 15. Phenylketonuria 16. Hearing loss 17. Familial hypercholesterolemia 18. Classification of genetic variants in hereditary cancer genes 19. RASopathies 20. Summary and conclusions

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Book SynopsisWhat does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact-based conclusion, but as the premise of a neo-Darwinian research program focused on selection. The successes of this research program created a blind spot - in mathematical models and verbal theories of causation - that has stymied efforts to re-think the role of variation. However, recent theoretical and empirical work shows that mutational biases can and do influence the course of evolution, including adaptive evolution, through a first come, first served mechanism.This thought-provoking book cuts through the conceptual tangle at the intersection of mutation, randomness, and evolution, offering a fresh, far-reaching, and testable view of the role of variation as a dispositional evolutionaTable of Contents1: Introduction: A Curious Disconnect 2: Ordinary Randomness 3: Practical Randomness 4: Evolutionary Randomness 5: Mutational Mechanisms and Evolvability 6: Randomness as Irrelevance 7: The Problem of Variation 8: Climbing Mount Probable 9: The Revolt of the Clay 10: Moving On Appendix A: Mutation Exemplars Appendix B: Counting the Universe of Mutations Appendix C: Randomness Quotations Appendix D: Irrelevance Quotations

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Book SynopsisHow Genes Influence Behavior takes a personal and lively approach to the study of behavioral genetics, providing an up-to-date and accessible introduction to a variety of approaches and their application to a wide range of disorders, and modeling a critical approach to both methods and results.This second edition includes additional biology content to help students understand the biological foundations of the field, while maintaining an appropriate focus on the main issues of relevance to psychology students; updates coverage of genomic technologies and their applications; and covers a wider range of disorders, including autism spectrum disorder, eating disorders, and intellectual disability. A new final chapter guides students through a range of quantitative approaches using worked examples that relate directly to cases and examples used earlier in the text, and addresses current issues arising from debates around reproducibility. The online resources that accompany this book include:Trade ReviewThe breadth of knowledge that is required to prepare a new generation of behavior geneticists is certainly present in the 2nd edition of How Genes Infuence Behavior * Tinca J. C. Polderman, Behavior Genetics, 07 June 2021 *Easy to read, comprehensive, up to date. The entertaining writing style will enthuse many new students, as will the low price. * Tinca J. C. Polderman, Behavior Genetics, 07 June 2021 *The authors are to be applauded for sharing with us their fascinating journey through the world of genetic research (and Irish hostels, and tattoos), and as such delivering a great contribution to the behavior genetics literature. * Tinca J. C. Polderman, Behavior Genetics, 07 June 2021 *The book covers a wide variety of topics in appropriate depth and with an informative, but relatively informal, style. A major strength is its focus on the recently highlighted topic of reproducibility (and how to maximise this), which is an area in which students need to be suitably educated. * Dr William Davies, Cardiff University *Very easy to read, and the narrative makes it engaging. * Dr Michelle Luciano, University of Edinburgh *An excellent and easy-to-read, engaging textbook. * Professor Robert Gerlai, University of Toronto Mississaugu *Table of Contents1: Introduction 2: The genetic epidemiology of schizophrenia 3: Molecular biology of nucleic acids 4: Epigenetics, gene regulation, and 'omic technologies 5: Linkage and association 6: Genome wide association studies (GWAS) 7: Molecular genetics of schizophrenia 8: Autism spectrum disorder 9: Intellectual disability and developmental disorders 10: Anxiety, depression, and eating disorders 11: Alcoholism 12: The genetics of intelligence, personality, and personality disorders 13: Genes for what? 14: Genes and the environment 15: Mapping mouse behavior 16: Reverse genetics 17: Mutagenesis and the molecular dissection of circadian rhythms 18: Many vs. One: Genetic Variation in Flies and Worms 19: Comparative genomics 20: How genes influence behavior 21: How do we know a finding is true? Quantitative Approaches Appendix

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Book SynopsisAn Introduction to Molecular Evolution and Phylogenetics offers an engaging yet highly informative narrative to demonstrate how molecular data can be used to answer evolutionary questions.Trade ReviewEngaging and entertaining writing, with concepts clearly conveyed in a way accessible to less numerate students. It is by far one of the most enjoyable and interesting text books on evolutionary genetics I have read. * Simon Goodman, University of Leeds *Nothing else comes close in terms of completeness and accessibility to our students. Reading the text is almost like having a conversation. * Lawrence Mays, University of North Carolina at Charlotte *Table of Contents1. Introduction - The story in DNA ; 2. DNA - The immortal germline ; 3. Mutation - We are all mutants ; 4. Replication - Endless copies ; 5. Genome - Accident and design ; 6. Gene - Making an organism ; 7. Selection - Descent with modification ; 8. Drift - Chance and necessity ; 9. Species - Origin of species ; 10. Alignment - Same but different ; 11. Phylogeny - Tree of life ; 12. Hypotheses - Seeing the wood for the trees ; 13. Rates - Tempo and mode ; 14. Dates - Telling the time

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Book SynopsisThe most up-to-date and complete textbook for first time genomics students, Introduction to Genomics offers a fascinating insight into how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing.Trade ReviewReview from previous edition This book is great for introducing the field of genomics, providing the basic concepts underpinning the field, including cutting edge techniques, along with examples of its application. * Dr Emma Laing, University of Surrey *The writing is eloquent and engages the curious reader with a wide range of background stories. The practical applications are always highlighted. Rather than a text book studied to pass an exam, this book is a pleasure to read. * Dr Richard Bingham, University of Huddersfield *It's the best textbook that I have reviewed for upper level undergraduates. It has good basic coverage of human aspects, databases, and comparative genomics. I like the questions and problems at the end of the chapters. * Professor Michael Shiaris, University of Massachusetts Boston *Table of Contents1: Introduction 2: The Human Genome Project 3: Mapping, Sequencing, Annotation, and Databases 4: Evolution and Genomic Change 5: Genomes of Prokaryotes and Viruses 6: Genomes of Eukaryotes 7: Comparative Genomics 8: The Impact of Genomics on Human Health and Disease 9: Genomics and Anthropology 10: Transcriptomics 11: Proteomics 12: Metabolomics 13: Systems Biology

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Book SynopsisThe objective of this practical handbook is to provide ecologists (both students and researchers) with the scientific background necessary to assist with the understanding and implementation of best practice studies and analyses based on environmental DNA.Trade ReviewThis volume fills a much-needed gap, offering a gentle introduction into the field of environmental DNA, which will be especially useful for readers of minor to intermediate experience with environmental DNA. * Vasco Elbrecht, Centre for Biodiversity Genomics, University of Guelph, The Quarterly Review of Biology *An excellent instructional book or supplementary reading for any eDNA based classes...It is a timely and important addition to the field of molecular ecology, and will undoubtedly remain the go-to book on metabarcoding for several years. * Dr Anthony A. Charlton, Macquarie University, Sydney, Australia, Molecular Ecology *This book is a timely overview of eDNA as a complimentary and non-invasive approach for investigating and monitoring biodiversity. The book is an ideal introduction to all ecologists looking to eDNA, but also speaks to the more experienced researchers in molecular ecology. Lastly, it provides textbook material for university courses around the world. * Philip Francis Thomsen, Trends in Ecology & Evolution Journal *If you are contemplating moving into this topic, or just want to understand it better, do try and get your hands on a copy - something that might not be that easy just now as I understand the book has proved to be so popular that it is already having to be reprinted. * IMA FUNGUS *In a world faced with accelerating environmental change and loss of biodiversity, this book is a timely overview of eDNA as a complementary and noninvasive approach for investigating and monitoring biodiversity ... an ideal introduction to all ecologists looking to eDNA as a method of choice, but also speaks to the more experienced researchers in molecular ecology. Lastly, it provides textbook material for university courses around the world, where eDNA is continuously increasing in popularity. * Philip Francis Thomsen, Department of Bioscience, University of Aarhus, Trends in Ecology and Evolution *Table of Contents1: Introduction to environmental DNA (eDNA) 2: DNA metabarcode choice and design 3: Reference databases 4: Sampling 5: DNA extraction 6: DNA amplification and multiplexing 7: DNA sequencing 8: DNA metabarcoding data analysis 9: Single-species detection 10: Environmental DNA for functional diversity 11: Some early landmark studies 12: Freshwater ecosystems 13: Marine environments 14: Terrestrial ecosystems 15: Palaeoenvironments 16: Host-associated microbiota 17: Diet analysis 18: Analysis of bulk samples 19: The future of eDNA metabarcoding

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Book SynopsisWhat is responsible for the differences between the sexes in so many animals, from the brilliant plumage of birds of paradise to the antlers on deer? And why are the traits that distinguish the sexes sometimes apparently detrimental to survival? Even when they look more or less alike, why do males and females sometimes behave differently? Questions like these have intrigued scientists and the public alike for many years, and new discoveries are showing us both how wildly variable the natural world is, and how some basic principles can help explain much of that variation. Like natural selection, sexual selection is a process that results from differential representation of genes in successive generations. Under sexual selection, however, the crucial characteristics that determine whether an individual reproduces depend on sexual competition, rather than survival ability. This Very Short Introduction considers the history of our understanding of sexual selection, from Darwin''s key insights to the modern day. Considering the investment animals place on reproduction, variation in mating systems, sexual conflict, and the origin of sexual dimorphism, Marlene Zuk and Leigh Simmons discuss questions such as whether females can really choose between males on aesthetic grounds, and how sexual conflict is resolved in different species. They conclude with a consideration of the thorny question of how, and even if, sexual selection theory applies to humans.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.Trade Review[A] delightful book ... informative and insightful ... Sexual Selection is thin and relatively cheap, but it's packed with more information than other books four times the size and price. * Mark Greener, Fortean Times *An excellent, fascinating introduction to the recent discoveries that have revolutionized our understanding of competition over mates, mate choice and differences between the sexes. Darwin would have been both pleased and amazed. * Malte Andersson, Professor emeritus, Animal Ecology, University of Gothenburg *Zuk and Simmons' book is enjoyable and informative. * Journal of Mammalogy *Table of Contents1: Darwin's other big idea 2: Choosing from the field of competitors 3: Sex roles and stereotypes 4: Sexual selection after mating 5: Sexual conflict 6: Mating systems, or who goes with whom, and for how long 7: How sex makes species surviveFurther ReadingIndex

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Book SynopsisWritten primarily for students embarking on an undergraduate bioscience degree, this primer will review the essential biological concepts that underpin any programme of more advanced study and give early-stage undergraduates the opportunity to review topics about which they may feel under-prepared or less confident.Genetic medicine has entered an era of rapid expansion. It is no longer just relevant to families affected by rare congenital disorders, but has the potential to affect the diagnosis and treatment of most common complex diseases.The successful application of new genetic science in the decades ahead will depend on the next generation of undergraduates or university applicants, who are now planning their careers as Biologists and Clinicians.This primer explores core concepts about heredity and genome analysis, illustrates current clinical practice with case-histories, and discusses the potentials and pitfalls of personalised medicine.Table of Contents1: Nucleic Acids, Genes, and Genomes 2: Mutations and Genetic Variation 3: Laboratory Techniques and the Sequencing Revolution 4: The Application of Genetic Medicine in Childhood 5: Genetic Medicine for Adult Onset Disease 6: Pharmacogenetics and Personalised Medicine

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Book SynopsisAn award-winning physician and scientist makes the game-changing case that genetic females are stronger than males at every stage of life''A powerful antidote to the myth of a weaker sex'' Gina Rippon, author of The Gendered BrainFrom birth, genetic females are better at fighting viruses, infections and cancer. They do better at surviving epidemics and famines. They live longer, and even see the world in a wider variety of colours. These are the facts; they are simply stronger than men at every stage of life. Why? And why are we taught the opposite?Drawing on his wide-ranging experience and cutting-edge research as a medic, geneticist and specialist in rare diseases, Dr Sharon Moalem reveals how the answer lies in our genetics: the female''s double XX chromosomes offer a powerful survival advantage. And he calls for a long-overdue reconsideration of our one-size-fits-all view of the body and medicine - a view that still frames women through the lens of men. Revolutionary, captivating and utterly persuasive, The Better Half will make you see women, men and the survival of our species anew.''Brilliant, original and groundbreaking, highly readable and genuinely useful'' Daily MailTrade ReviewLet's hear it for the X-chromosome! After decades, if not centuries, of bad press for women and their vulnerable biology, The Better Half gives chapter and verse to show that 'almost everything that is biologically difficult to do in life is done better by females'. An eye- and mind-opening celebration of the reserve genetic horsepower that having two X-chromosomes can bestow, The Better Half is a powerful antidote to the myth of a 'weaker sex'. * Gina Rippon, author of The Gendered Brain and Professor Emeritus of Cognitive Neuroimaging at Aston University, Birmingham *Moalem's essential thesis is valid and important, and deserves attention both within the scientific community and beyond. This is a readable and lively book, making an argument long overdue * The Irish Independent *Although Dr. Moalem had me at the subtitle, I tore through this fascinating, eye-opening book in one sitting. Provocative, crackling with wit and insight, THE BETTER HALF argues that science has shortchanged women in all levels of research and convincingly reveals that the true differences between men and women come down to longevity, intellect, resilience, and immunity to disease. Now it all makes sense why 95 percent of people who have reached the age of 110 are women. -- Jancee Dunn * New York Times bestselling author of 'How Not to Hate Your Husband After Kids' *A mind-opening celebration of women -- Kate Garraway, broadcaster and journalistThis book provides the crucial scientific reasoning behind why it is essential to include males and females, both in people and animals, in order to get accurate results in medical research. * Temple Grandin, New York Times bestselling author of 'The Autistic Brain' and 'Thinking in Pictures' *A compelling argument for the resilience seen in women. But the real genius is the poetic justice he metes out by highlighting the brilliant women who remain unsung heroes in these discoveries. -- William J. Sullivan * Showalter Professor at Indiana University School of Medicine and author of 'Pleased to Meet Me' *The Better Half explores the genetic differences between males and females in a way that is both original and scientifically compelling. This book provides a great read, and lots to think about, for specialists and the public alike. -- Han G. Brunner, MD, PhD, Professor of Human Genetics at Radboud University Nijmegen Medical Center, and Maastricht University Medical Center, the Netherlands.Moalem brings deep, yet highly-readable, scientific analysis to the perennial question of what makes men and women different. Ideally, this book will re-set that conversation in research labs, doctors' offices, classrooms, and dinner tables around the world." -- E. Kinney Zalesne, New York Times bestselling collaborator on 'Microtrends: The Small Forces Behind Tomorrow's Big Changes'

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Book SynopsisCreation by Adam Rutherford tells the entire spellbinding story of life in two gripping narratives.''Prepare to be astounded. There are moments when this book is so gripping it reads like a thriller'' Mail on SundayThe Origin of Life is a four-billion-year detective story that uses the latest science to explain what life is and where it first came from, offering answers to the very grandest of questions before arriving at a thrilling solution.''A superbly written explanation'' Brian CoxThis same science has led to a technological revolution: the ability to create entirely new life forms within the lab, known as synthetic biology. The Future of Life introduces these remarkable innovations, explains how they work, and presents a powerful argument for their benefit to humankind.''The reader''s sense of awe at the well-nigh inconceivable nature of nature is suitably awakened. The extraordinary scienceTrade ReviewPrepare to be astounded. There are moments when this book is so gripping it reads like a thriller * Mail on Sunday *One of the most eloquent and genuinely thoughtful books on science over the past decade. You will not find a better, more balanced or up-to-date take on the origin of life or synthetic biology. Essential reading for anyone interested in the coming revolution, which could indeed rival the Industrial Revolution or the internet * Observer *Fascinating. The reader's sense of awe at the well-nigh inconceivable nature of nature is suitably awakened. The extraordinary science and Rutherford's argument are worth every reader's scrutiny * Sunday Telegraph *The perfect primer on the past and future of DNA * Guardian *

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Book SynopsisProteomics aims to study all the proteins of human and other living systems, as well as their properties to provide an integrated view of cellular processes. The study of proteomics involves the application of rapidly evolving high-throughput technologies and new platforms that are coming forward regularly, providing versatile novel tools for biomedical and pharmaceutical applications. This book provides a detailed understanding of the basics of proteins and proteomics, gel based-proteomics techniques, basics of mass spectrometry and quantitative proteomics, interactomics: basics and applications, and advancements in proteomics. It also covers basic knowledge about sample preparation, mass spectrometry workflow, different chromatography technologies and quantitative proteomics.The text highlights the application and challenges of various high-throughput integrated proteomics technologies capable of fast and accurate screening of thousands of biomolecules, which are fouTable of ContentsModule 1: Basics of proteins and proteomicsBasics of amino acids and proteinsProtein chemistry to proteomicsModule 2: Gel-based proteomics techniquesGel-based proteomics2-d difference in gel electrophoresis (2d-dige)Gel-based proteomic data analysisModule 3: Basics of mass-spectrometry and quantitative proteomicsIntroduction to mass spectrometryHybrid mass spectrometry configurationsTandem mass spectrometry for protein identificationIn vitro quantitative proteomics using itraqIn vivo quantitative proteomics using silacModule 4: Interactomics: basics and applicationIntroduction to interactomicsAntigen and antibody microarraysCell-free expression based protein microarraysNucleic acid programmable protein arraysLabel-free proteomicsSurface plasmon resonanceSurface plasmon resonance imagingProtein interaction analysis using spr and spriModule 5: Advancement in proteomicsProteomics for translational researchFuture of proteomics for clinical applicationsChallenges in clinical proteomics

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Book SynopsisIn this unique amalgam of neuroscience, genetics, and evolutionary psychology, Ryan argues that leftists and rightists are biologically distinct versions of the human species that came into being at different moments in human evolution.The book argues that the varying requirements of survival at different points in history explain why leftists and rightists have anatomically different brains as well as radically distinct behavioral traits. Rightist traits such as callousness and fearfulness emerged early in evolution when violence was pervasive in human life and survival depended on the fearful anticipation of danger. Leftist traits such as pro-sociality and empathy emerged later as environmental adversity made it necessary for humans to live in larger social groups that required new adaptive behavior. The book also explores new evolutionary theories that emphasize the role of the environment in shaping not only human political behavior but also humans' genetic architecture. Trade Review"Michael Ryan synthesizes an absolutely incredible amount of information to arrive at a provocative conclusion regarding the difference between rightists and leftists." -- John R. Hibbing, University of Nebraska-Lincoln, USA"This important book is a sparklingly original natural history of the age-old conflict between left and right." -- Richard Wrangham, Harvard University, USA"Do liberal forms of cooperation and pacifism and conservative forms of competition and authoritarianism have deep origins in our evolutionary history? In prose that is skilled and accessible, Michael P. Ryan makes a passionate, provocative argument that they do. He has read seemingly everything, and he pulls no punches. His book provides food for thought, worry, and, surprisingly, hope." -- John T. Jost, New York University, USA Table of ContentsPreface1. Political Adaptations2. Evolutionary Models 3. Traits, Brains, Genes4. Art and the Origin of Civilization 5. The Genetic Geography of Conservatism6. Religion as Adaptation7. European History in Light of Evolution 8. Violence Against Others: Torture, Genocide, War9. The Psychology of Political Correctness 10. Leftist Form and Rightist Substance11. Dominance and Deception in Economics12. Is Socialism Adaptive? The Future of H. sapiensConclusionFuture WorkNotes

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Book SynopsisComplete with guidelines for genetic screening and counseling, this enlightening handbook should be on the shelf of every geneticist, genetic counselor, cross-cultural counselor, genetics and health care professional, and professional-in-training.Trade ReviewAn excellent addition to the human genetics library. This book should reach not only genetics professionals but all health care providers... [It] is the first global attempt by several experts from diverse backgrounds to address specific ethnic and cultural beliefs and their implications for genetic services. It is long overdue! Alliance Alert The book succeeds in making the reader aware of the ethnic groups that [geneticists] might meet... If you see this book on your shelf, do pick it up... You will find the book fascinating. Journal of Medical GeneticsTable of ContentsContributorsForewordAcknowledgementsIntroductionChapter 1. European Culture in North AmericaChapter 2. Latino CultureChapter 3. African American CultureChapter 4. Culture of Native Americans of the SouthwestChapter 5. Traditional Chinese CultureChapter 6. Traditional Japanese CultureChapter 7. Culture of the Countries of Southeast AsiaChapter 8. Traditional Korean CultureChapter 9. Traditional Asian Indian CultureChapter 10. Christian Culture in North AmericaChapter 11. Amish CultureChapter 12. Jewish Culture in North AmericaChapter 13. Deaf CultureIndex

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Book SynopsisThe rise of the multi-billion dollar ancestry testing industry points to one immutable truth about us as human beings: we want to know where we come from and who our ancestors were. John H. Relethford and Deborah A. Bolnick explore this topic and many more in this second edition of Reflections of Our Past.Where did modern humans come from and how important are the biological differences among us? Are we descended from Neandertals? How should we understand the connections between genetic ancestry, race, and identity? Were Native Americans the first to inhabit the Americas? Can we see evidence of the Viking invasions of Ireland a millennium ago even in the Irish of today? Through engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to suggest answers to fundamental questions about human history. By looking at genetic variation in the world today and in the past, we can reconstruct the recent and remote events and processes that have created the variation we see, providing a fascinating reflection of our genetic past.Trade Review"Reflections of Our Past is an engaging and accessible work about the genetic history of humankind expressed without the confusing jargon so often found in the literature in this field." —Gerrell Drawhorn, CSU-Sacramento"For anyone curious about the science behind the DNA ancestry tests whose commercials inundate our TVs, this book is a must read." —Justin Garcia, Millersville University of Pennsylvania"[A] readable, relevant, accurate book by two top-notch, trustworthy researchers on an important and often misunderstood topic." —Sheela Athreya, Texas A&MTable of ContentsPreface1. The History in Our Genes2. The Naked Ape3. Out of Africa: Our Genetic Legacy4. The Fate of the Neandertals (and Other Archaeic Humans)5. The First Inhabitants of the Americas6. Genetics and the Spead of Agriculture in Europe7. Voyagers of the Pacific8. Three Tales from Ireland9. Admixture and History10. Ancestory, Identity, and Race

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Book SynopsisThere is no such thing as an average person, we are all genetically and biologically unique. But when sperm meets egg, our characteristics are not locked in stone. This work argues that bad genes do not necessarily cause disease by themselves, and nutrition and environment can alter the outcome.

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Book SynopsisThis important book traces the history of genetics and genomics policy in Britain. Detailing the scientific, political, and economic factors that have informed policy and the development of new health services, the book highlights the particular importance of the field of Public Health Genomics.Although focused primarily on events in Britain, the book reveals a number of globally applicable lessons. The authors explain how and why Public Health Genomics developed and the ways in which genetics and genomics have come to have a central place in many important health debates. Consideration of their ethical, social, and legal implications and ensuring that new services that are equitable, appropriate, and well-targeted will be central to effective health planning and policymaking in future.The book features: Interviews with leading individuals who were intimately involved in the development of genetics and genomics policy and Public Health Genomics InsigTable of Contents0.Introduction. 1.Origins. 2.Foundations. 3.Progress. 4.New Directions. 5.Conclusion

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Book SynopsisThis book illustrates that the stereotypical representations of Gregor Mendel and his work misrepresent his findings and their historical context. The author sets the historical record straight and provides scientists with a reference guide to the respective scholarship in the early history of genetics. The overarching argument is twofold: on the one hand, that we had better avoid naïve hero-worshipping and understand each historical figure, Mendel in particular, by placing them in the actual sociocultural context in which they lived and worked; on the other hand, that we had better refrain from teaching in schools the naive Mendelian genetics that provided the presumed scientific basis for eugenics.Key Features Corrects the distorting stereotypical representations of Mendelian genetics and provides an authentic picture of how science is done, focusing on Gregor Mendel and his actual contributions to science Explains how the oversimplifications of MendelianTrade Review“Gregor Mendel’s bicentenary has rightly made us reassess every aspect of his legacy. Like many I first heard about Mendel at school, but could the way we introduce genetics in formal education constrain rather than encourage thought? Kostas Kampourakis provides a highly accessible but rigorous guide to how the debates at the birth of genetics foreshadow today’s controversies, and raises many fascinating questions about how the framing of some ultimately simple patterns of germline inheritance may influence how we think about how humankind is and how it could be” – George Davey Smith, Professor of Clinical Epidemiology, Bristol Medical School (PHS), University of Bristol “In How We Get Mendel Wrong and Why it Matters, Kampourakis expertly refocuses our attention away from modern genetics as a “great man” project borne from the pea-experiments of one cloistered genius. As he shows, cracking the mysteries of genetics was always a community-wide endeavor, requiring dozens of creative minds working hard for generations. Kampourakis’ research also peels away our prejudice that scientific ideas float free of their socio-political moorings. The genes-as-marbles analogy never accurately described what Mendel was after. But those mistaken assumptions served a whole cadre of unsavory interests from the very beginning—and arguably still do. This carefully crafted, compelling account kicks the scientific legs out from under the myths that have propped up eugenics and scientific racism for generations. For that reason, this book is a must read for anyone who hopes to understand not simply the true story of Mendel and early genetics, but also how science-flavored tales bend policy, education, and political priorities.” – Erik L. Peterson, Associate Provost for General Education & Associate Professor of the History of Science & Medicine, The University of Alabama “Kostas Kampourakis issues a critical challenge to the life sciences: Is Mendel now doing more harm than good? Where classical 20th century Mendelism posits the division of the genome into discrete elements that we now call genes, and the direct association of those genetic elements with particular organismal features, Kampourakis argues forcefully that we now know both of those assumptions to be gross oversimplifications, if not outright fallacies. Consequently perhaps Gregor Mendel, the great mythic founder of genetics, has run his course in that role, and we should re-think how we teach about human heredity. He’s definitely got a good point!” – Jonathan Marks, Professor of Anthropology, UNC-Charlotte “Kostas Kampourakis has made a name for himself as one of our clearest expositors and interpreters of the history of the life sciences. In How We Get Mendel Wrong, and Why it Matters he tells the story of the origins of genetics, and ends with a punch: an innovative new way to teach it. Applied history of science at its best, this is essential reading not only for geneticists, teachers and administrators, but also for the general public.” – Oren Harman, author of The Price of Altruism, The Man Who Invented the Chromosome, and Evolutions: Fifteen myths that Explain Our World "How We Get Mendel Wrong, and Why It Matters pulls the rug out from under the standard readings of genetics’ origin story, challenging fundamental assumptions about what Mendel knew, why he conducted those experiments on peas, how his work was received at the turn of the twentieth century, and—most importantly—why the received view that continues to dominate biology textbooks is so dangerous. Kampourakis distills work from history of science, philosophy of science, biology, and educational policy and practice, making that extensive literature accessible. This radical reimagining of that famous “father of genetics” is not to be missed." – James Tabery, Professor in the Department of Philosophy, University of Utah “In How We Get Mendel Wrong and Why it Matters, Kostas Kampourakis provides a thorough update of the history of Mendel and Mendelism, debunking powerful myths, reminding us of eugenic misuses, and calling for new ways of teaching genetics.” – Staffan Müller-Wille, University of Cambridge “What if Gregor Mendel and his famous pea experiments were not the foundation of the science of heredity? Kostas Kampourakis provides a lucid, concise guide to a radical shift in how we think about genes and DNA—one that has the potential to radically revise the way we teach, and do, genetics.” – Nathaniel Comfort, Professor, Department of the History of Medicine, Johns Hopkins University "The myths that cling to Gregor Mendel and his legacies do him -- and us -- a huge disservice. In this superb book, Kostas Kampourakis presents the general reader with a first-rate introduction to the demythologized story, from Mendel's day to our own. The lessons drawn, especially for the genetics classroom, should be required reading for anyone concerned to make biology education fit for purpose in the twenty-first century." – Gregory Radick, Professor of History and Philosophy of Science, University of Leeds Table of ContentsPreface: “Gregor Mendel, the first geneticist”. Part I Anachronistic Mendelism. Chapter 1 Mendel was not a geneticist ahead of his time. Chapter 2 Mendel was a brilliant experimentalist of his time. Chapter 3 Speculating about heredity. Chapter 4 The path to genetics. Chapter 5 The reification of the “lonely genius”. Part II Social Mendelism. Chapter 6 Mendel’s great defender. Chapter 7 Chromosomes, “factors” and genes. Chapter 8 “Mendelian” eugenics. Chapter 9 Geneticists’ attitudes towards “Mendelian” eugenics. Chapter 10 Mendelian genetics and the Nazi racial hygiene. Conclusions: Emending the teaching of school genetics.

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Book SynopsisThe bestselling introduction to bioinformatics and genomics now in its third edition Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline.Table of ContentsPart I Analyzing DNA, RNA, and Protein Sequences 1 Introduction 3 2 Access to Sequence Data and Related Information 19 3 Pairwise Sequence Alignment 69 4 Basic Local Alignment Search Tool (BLAST) 121 5 Advanced Database Searching 167 6 Multiple Sequence Alignment 205 7 Molecular Phylogeny and Evolution 245 Part II Genomewide Analysis of DNA, RNA, and Protein 8 DNA: The Eukaryotic Chromosome 307 9 Analysis of Next-Generation Sequence Data 377 10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433 11 Gene Expression: Microarray and RNA-seq Data Analysis 479 12 Protein Analysis and Proteomics 539 13 Protein Structure 589 14 Functional Genomics 635 Part III Genome Analysis 15 Genomes Across the Tree of Life 699 16 Completed Genomes: Viruses 755 17 Completed Genomes: Bacteria and Archaea 797 18 Eukaryotic Genomes: Fungi 847 19 Eukaryotic Genomes: From Parasites to Primates 887 20 Human Genome 957 21 Human Disease 1011 Glossary 1075 Self-Test Quiz: Solutions 1103 Author Index 1105 Subject Index 1109

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Book SynopsisThis revised third edition provides an up to date, comprehensive overview of the field of comparative psychology, integrating both evolutionary and developmental studies of brain and behavior. This book provides a unique combination of areas normally covered independently to satisfy the requirements of comparative psychology courses. Papini ensures thorough coverage of topics like the fundamentals of neural function, the cognitive and associative capacities of animals, the development of the central nervous system and behavior, and the fossil record of animals including human ancestors. This text includes many examples drawn from the study of human behavior, highlighting general and basic principles that apply broadly to the animal kingdom. New topics introduced in this edition include genetics, epigenetics, neurobiological, and cognitive advances made in recent years into this evolutionary-developmental framework.An essential textbook for upper level undTable of Contents1. Biological Evolution1.1 Evidence for Evolution1.2 Logic of Natural Selection1.3 Origin and Preservation of Genetic Variability1.4 Natural Selection1.5 Glossary1.6 References2. Origin and Evolution of Animals2.1 Diversity of Life2.2 Geological Background2.3 Origin and Evolution of Animals2.4 Speciation2.5 Grades and Clades2.6 Glossary2.7 References3. Evo-devo, Brain, and Behavior3.1 Definitions3.2 Early Development3.3 Development of the Vertebrate Nervous System3.4 Development and evolution3.5 Terminology3.6 Behavior3.7 Glossary3.8 References4. Simple Nervous Systems and Behavior4.1 Invertebrate Phyla4.2 Behavior and Simple Neural Networks4.3 Behavioral and Neural Plasticity in Nonassociative Learning4.4 Evolution of Learning Mechanisms in Mollusks4.5 Glossary4.6 References5. Evolution of the Vertebrate Brain and Behavior5.1 Key Innovations of Vertebrates5.2 Comparative Neurology5.3 Telencephalon5.4 Brain Size5.5 Glossary5.6 ReferencesChapter 6: Fundamentals of Learning and Cognition6.1 Definitions6.2 Forms of Conditioning6.3 Classical Conditioning6.4 Instrumental Conditioning6.5 Situational Generality of Associative Learning6.6 Brain Mechanisms of Learning and Cognition: An Overview6.7 Glossary6.8 References7. Comparative Analysis of Learning and Cognition7.1 Comparative Methodology7.2 Learning and Cognition in Invertebrates7.3 Learning and Cognition as Adaptations7.4 Learning, Cognition, and Phylogenetic History7.5 Glossary7.6 References8. Higher Cognitive Processes8.1 From Associative Learning to Cognition8.2 From Concepts to Social Cognition8.3 Mental Continuity and Discontinuity8.4 Glossary8.5 References9. Early Learning and Behavior9.1 Ontogenetic Transitions9.2 Prenatal and Prehatching Behavior9.3 Infant Behavior9.4 Infant Learning9.5 Development of Complex Behavior9.6 Glossary9.7 References10. Early Social Learning and Behavior10.1 From Individual to Social Behavior10.2 Imprinting10.3 Reproductive and Social Behavior10.4 Development of Vocal Behavior10.5 Glossary10.6 References11. Reproductive and Social Behavior11.1 Reproductive Biology and Social Behavior11.2 Mechanisms Underlying Social Behavior11.3 Mating Systems11.4 Patterns of Reproductive Behavior11.5 Infant Care11.6 Complex Animal Societies11.7 Glossary11.8 References12. Brain, Behavior, and Evolution of Primates12.1 What is a Primate?12.2 The Primate Brain12.3 Evolution of Language12.4 Origin of Primates12.5 Hominids12.6 From Archaic to Modern Humans12.7 Conclusion: From Oldowan Tools to Climate Change12.8 Glossary12.9 References

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Book SynopsisThe concepts of veterinary genetics are crucial to understanding and controlling many diseases and disorders in animals. They are also crucial to enhancing animal production. Accessible and clearly presented, Introduction to Veterinary Genetics provides a succinct introduction to the aspects of genetics relevant to animal diseases and production. Now in its third edition, this is the only introductory level textbook on genetics that has been written specifically for veterinary and animal science students. Coverage includes: basic genetics, molecular biology, genomics, cytogenetics, immunogenetics, population genetics, quantitative genetics, biotechnology, and the use of molecular tools in the control of inherited disorders. This book describes in detail how genetics is being applied to artificial selection in animal production. It also covers the conservation of genetic diversity in both domesticated and wild animals. New for the Third Edition: Table of ContentsPreface 1 Basic genetics Chromosomes Meiosis and mitosis The biochemistry of inheritance What is a gene? Gene regulation Mutation Genes, alleles, and loci Simple or Mendelian inheritance Linkage Inactivation Types of DNA Further reading Appendix 1.1 Banded karyotypes of domestic species 2 Molecular biology Restriction enzymes Recombinant DNA and DNA cloning Complementary DNA DNA sequencing Polymerase chain reaction Southern analysis and related technologies DNA expression microarrays The detection of variation in base sequence Veterinary diagnosis Variable number of tandem repeats (VNTR), DNA fingerprints, and microsatellites Single nucleotide polymorphisms (SNPs) Copy number variation (CNV) Gene mapping Whole-genome sequence assembly Production of polypeptide from cloned DNA Transgenesis Antisense technology RNA interference Further reading 3 Single-gene disorders Inborn errors of metabolism Sex-limited inheritance Genetic heterogeneity of disease Type of gene action and type of disease Phenocopies A sample of single-gene disorders A revolution in mapping and identifying the causal mutation of single-gene disorders Further reading Appendix 3.1 A sample of single-gene traits that have been characterized at the molecular level 4 Chromosomal aberrations Abnormal chromosome number Abnormal chromosome structure Chromosomal aberrations in cancer Evolution of karyotypes Interspecific hybridization Freemartins Biological basis of sex Classification of intersex 116 A sample of chromosomal aberrations Further reading Appendix 4.1 A sample of chromosomal aberrations in animals 5 Single genes in populations Gene and genotype frequencies Random mating The Hardy–Weinberg law Extensions to the Hardy–Weinberg law Selection and mutation Genetic drift and the founder effect Extending population genetics to more than one locus Further reading 6 Familial disorders not due to a single gene Liability and threshold The multifactorial model More than one threshold Some final points Further reading 7 Is it inherited? General evidence for a genetic aetiology The four types of simple, Mendelian inheritance Studying and analysing the data Further reading 8 Immunogenetics Antibodies Red-cell antigens The major histocompatibility complex (MHC) Further reading 9 Pharmacogenetics Genetic polymorphisms affecting drug metabolism Genetics and anaesthesia Warfarin resistance Multifactorial pharmacogenetics Further reading 10 Hosts, parasites, and pathogens Host–pathogen interactions Resistance in hosts Resistance in parasites and pathogens Control of parasites and pathogens Increasing the level of resistance in hosts Further reading 11 Single genes in animal breeding Coat colour Examples of coat-colour genes Carpet wool Prolificacy in sheep Polledness Muscular hypertrophy in cattle and sheep Dwarf poultry Genes for sexing chickens Pedigree checking Further reading 12 Relationship and inbreeding The inbreeding coefficient Relationship The inbreeding coefficient revisited A general expression for relationship and inbreeding The base population Inbreeding in populations Inbreeding depression Further reading 13 Quantitative variation Quantitative traits The performance of an individual animal The differences between animals Heritability Correlations between traits Quantitative trait loci (QTL) Further reading 14 Selection between populations Comparison between populations Genotype–environment interaction Further reading 15 Selection within populations Estimated breeding values and accuracy of selection Clues to a candidate’s breeding value for a trait Combining clues from more than one source Best linear unbiased prediction (BLUP) Correlated traits Selection for more than one trait The importance of inbreeding and genetic drift Sire-reference schemes Marker-assisted selection (MAS) and genome-wide selection (GWS) Further reading 16 Breed structure The traditional pyramid Closed-nucleus breeding schemes Open-nucleus breeding schemes Further reading 17 Crossing Regular crossing Crossing to produce a synthetic Grading-up Further reading 18 Selection and regular crossing Selection Selection and regular crossing Further reading 19 Biotechnology and the future Artificial insemination (AI) Multiple ovulation and embryo transfer (MOET) In vitro maturation (IVM) and in vitro fertilization (IVF) of ova Control of sex ratio Recombinant proteins Transgenesis Animal cloning Further reading 20 Conservation genetics Measurement of genetic diversity within populations Measurement of genetic diversity among populations Importance of genetic diversity Loss of genetic diversity Conservation of genetic diversity Further reading 21 Genetic and environmental control of inherited disorders Environmental control of inherited disorders Genetic control of single-gene disorders Gene therapy Genetic control of multifactorial disorders Genetic control – some final points Crossing: thinking outside the square Further reading Glossary Index

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Book SynopsisIllustrated thoroughly, Biomolecular Archaeology is the first book to clearly guide students through the study of ancient DNA: how to analyze biomolecular evidence (DNA, proteins, lipids and carbohydrates) to address important archaeological questions. The first book to address the scope and methods of this new cross-disciplinary area of research for archaeologists Offers a completely up-to-date overview of the latest research in this innovative subject Guides students who wish to become biomolecular archaeologists through the complexities of both the scientific methods and archaeological goals. Provides an essential component to undergraduate and graduate archaeological research Trade Review"Thenumerous figures and tables are clear and useful throughout, and a valuableglossary is also provided." (Journalof the Royal Anthropological Institute, 25 January 2013)Table of ContentsList of Figures. List of Tables. Preface. Part I: Biomolecules and How They Are Studied. Chapter 1 What is Biomolecular Archaeology? Chapter 2 DNA. Chapter 3 Proteins. Chapter 4 Lipids. Chapter 5 Carbohydrates. Chapter 6 Stable Isotopes. Part II: Preservation and Decay of Biomolecules in Archaeological Specimens. Chapter 7 Sources of Ancient Biomolecules. Chapter 8 Degradation of Ancient Biomolecules. Chapter 9 The Technical Challenges of Biomolecular Archaeology. Part III: The Applications of Biomolecular Archaeology. Chapter 10 Identifying the Sex of Human Remains. Chapter 11 Identifying the Kinship Relationships of Human Remains. Chapter 12 Studying the Diets of Past People. Chapter 13 Studying the Origins and Spread of Agriculture. Chapter 14 Studying Prehistoric Technology. Chapter 15 Studying Disease in the Past. Chapter 16 Studying the Origins and Migrations of Early Modern Humans. Glossary. Index.

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Book SynopsisA clear and straightforward explanation of genetics in this new edition of the popular 101 series. Our genetic makeup determines so much about who we are, and what we pass on to our children—from eye color, to height, to health, and even our longevity. Genetics 101 breaks down the science of how genes are inherited and passed from parents to offspring, what DNA is and how it works, how your DNA affects your health, and how you can use your personal genomics to find out more about who you are and where you come from. Whether you’re looking for a better scientific understanding of genetics, or looking into your own DNA, Genetics 101 is your go-to source to discover more about both yourself and your ancestry.

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Book SynopsisSynthetic biology will revolutionize how we define family, how we identify disease and treat aging, where we make our homes, and how we nourish ourselves. This fast-growing field-which uses computers to modify or rewrite genetic code-has created revolutionary, groundbreaking solutions such as the mRNA COVID vaccines, IVF, and lab-grown hamburger that tastes like the real thing. It gives us options to deal with existential threats: climate change, food insecurity, and access to fuel.But there are significant risks.Who should decide how to engineer living organisms? Whether engineered organisms should be planted, farmed, and released into the wild? Should there be limits to human enhancements? What cyber-biological risks are looming? Could a future biological war, using engineered organisms, cause a mass extinction event? Amy Webb and Andrew Hessel's riveting examination of synthetic biology and the bioeconomy provide the background for thinking through the upcoming risks and moral dilemmas posed by redesigning life, as well as the vast opportunities waiting for us on the horizon.

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The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.

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Book SynopsisLearn how your DNA can empower you to make life choices that lead to a happier, healthier lifeThe personalized medicine wave is here.In this book, biotechnology entrepreneur and CEO of The DNA Company Kashif Khan offers an action plan to help you live your best life. It starts by understanding your genetic makeup.The DNA Way is a preventative guide to various health issues and their link to an individual’s DNA. In it, readers will discover what the DNA Company experts have learned about chronic illness and genetic predispositions, based on years of in-depth genetic analysis of the DNA results of more than 7,000 people. Topics that will be addressed include mood and behavior, energy, diet and nutrition, weight management, sleep, and more. The book will delve into Kashif’s personal journey of overcoming his own genetic legacy and health challenges—using his own DNA results as a case study—and in navigating that journey, how he came to develop a company whose aim is to elevate humanity. It also outlines recommendations—including what foods to eat, how to exercise, and where and how to work—that have helped him prevent or reverse illness, slow down the aging process, and optimize his performance.Learn how to access your human instruction manual—the DNA way.

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Book SynopsisGene expression in cells follows a prescribed pathway that conforms to the Central Dogma; where the genetic information stored in DNA is transcribed into RNA and then expressed into proteins, which influences most plant traits. Plant salt tolerance research is directed towards identifying nucleotide variants that could contribute to tolerant phenotypes. This book comprehensively presents the current state of knowledge on plant salt tolerance through meticulous analysis of the processes operating across the Central Dogma. It provides a detailed account of modulation of gene expression through genome editing systems to achieve crop improvement against salt stress. It also provides state-of-the-art information on advances in breeding technologies of genome selection and accelerated de novo domestication for rapidly improving the salt tolerance of plants for global food security.This book:1.Provides a comprehensive coverage of plant salt tolerance mechanisms.2.Spotlights

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Book SynopsisGenome sequencing is one of the most exciting scientific breakthroughs of the past thirty years. But what precisely does it involve and how is it developing? In this brilliantly wide-ranging, one-stop guide WIRED journalist Rachael Pells explains the science behind genomics. She analyses its practical applications in medical diagnosis and the treatment of conditions that range from cancer to severe allergic reactions to cystic fibrosis. She considers its potential to help with advances in agriculture and environmental science. She explores the ethics of genetic modification and the dangers involved when humans 'play God'. And she addresses the fundamental question: to what extent will future advances transform human longevity and the quality of life.

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Book SynopsisThis is an introductory text and laboratory manual to be used primarily in undergraduate courses. It is also useful for graduate students and research scientists who require an introduction to the theory and methods of nanopore sequencing. The book has clear explanations of the principles of this emerging technology, together with instructional material written by experts that describes how to use a MinION nanopore instrument for sequencing in research or the classroom.At Harvard University the book serves as a textbook and lab manual for a university laboratory course designed to intensify the intellectual experience of incoming undergraduates while exploring biology as a field of concentration. Nanopore sequencing is an ideal topic as a path to encourage students about the range of courses they will take in Biology by pre-emptively addressing the complaint about having to take a course in Physics or Maths while majoring in Biology. The book addresses this complaint by concretely demonstrating the range of topics — from electricity to biochemistry, protein structure, molecular engineering, and informatics — that a student will have to master in subsequent courses if he or she is to become a scientist who truly understands what his or her biology instrument is measuring when investigating biological phenomena.

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Book SynopsisTrade Review"Finalist for the PROSE Award in Popular Science and Mathematics, Association of American Publishers""How billions of neurons come together to turn thought into action is astounding in itself, but cognitive neuroscientist David Badre takes this to new levels in his book."---Amy Barrett, BBC Science Focus Magazine"On Task is a stimulating, enjoyable read for anyone interested in brain function, particularly if you want to understand how researchers are attempting to unravel some of the biggest mysteries of them all: how humans think, how they are successful when confronted with new challenges and how prefrontal cortex might contribute to that success."---Masud Husain, Brain"Badre provides a thorough and engaging introduction to the history of the study of cognitive control, and an overview of new developments from the last 20 years."---Zsuzsa Kaldy, Current Biology"I would definitely recommend On Task to anyone who is interested in metacognition and understanding how your brain makes decisions."---Leslie Hamachi, Chemistry World

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Book SynopsisD.

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Book SynopsisRecent social and political psychological research indicates that increased access to ancestry testing has strengthened the notion of genetic essentialism among some groups, or the idea that our biology ties us to particular ethnic identities. This can boost a sense of cultural pride and prosocial behaviors among communities that are perceived to be similar. In the worst-case scenarios, however, this phenomenon can contribute to deeper social woes like misinformation, anti-science agendas, and even social hatred among those who believe in racial superiority. Using research from both the social sciences and the genetics literature as support, Ancestry Reimagined establishes realistic expectations about what we can learn from our DNA as a foundation for examining the psychological impact of ancestry testing, including the differences between how this information is perceived versus its reality. With this book, Dr. Kampourakis flexes his muscles as an esteemed interdisciplinary science edTrade ReviewA fascinating and personal journey into the complex relationship between ancestry, ethnicity and identity. Kampourakis' book provides food for thought for anyone curious about what genetic ancestry tests actually measure and what, if anything, we can learn from their results. * Iain Mathieson, Department of Genetics, Perelman School of Medicine, University of Pennsylvania *Ancestry Reimagined is an urgently needed book. It explains how modern misconceptions of genetic determinism are becoming mixed into notions of race essentialism to create confusions of identity that are being commercially monetised. While genomics has immense potential to elucidate human origins and history, this book is a splendidly clear corrective to some of its scientific, technological and societal misuses and misunderstandings. * Philip Ball, science writer and author of How To Grow a Human *I have more sympathy for DNA testing than does Kostas Kampourakis - if people seek slightly bizarre information about themselves, why not? Many might value such an exploration. Nonetheless, he convincingly shows the distortions, emotional tangles, politically dicey inferences, and plain silliness that test misuse can entail. Ancestry Re-Imagined is clear, elegant, engaged, and absorbing; no one will misunderstand genetic ancestry testing after reading it. * Jennifer Hochschild, Henry LaBarre Jayne Professor of Government, Harvard University, and author of Genomic Politics (OUP) *Genetic essentialism is at the root of many of our societal problems. Kampourakis brilliantly dissects misconceptions concerning modern genetic ancestry testing, notions of socially defined race and ethnicity, and how it impacts individuals' understandings of themselves and their families. This is done in an engaging style. A must read. * Joseph L. Graves Jr, Professor of Biological Sciences, North Carolina A&T State University and author of Racism, Not Race (with Alan Goodman) *Who do you think you are? In today's world of identity politics, finding your roots has never seemed so important. You'd think your DNA would have answers to all your questions. That's science, right? But as Kostas Kampourakis shows in this timely book, your DNA is a very deceptive guide to discovering your ancestry. * Dr Henry Gee, Senior Editor at Nature, and author of A (Very) Short History of Life on Earth, and The Accidental Species: Misunderstandings of Human Evolution *Kostas Kampourakis has written a book that everyone who is either considering submitting a sample for DNA testing to a commercial ancestry company or who is trying to interpret the results of such a test should read. He explains in a clear and comprehensible manner basic genetics, the different tools used by genetic ancestry companies to evaluate ancestry, and exactly what these tests can and cannot do. In particular, he presents the reasons that the results of such tests are not and cannot be taken as proof of identity or ethnicity. Ancestry Re-Imagined goes beyond most books on DNA testing by discussing the psychological tendency toward essentializing the results of such tests, thus explaining why and how people distort these tests to various ends. Finally, it warns of the dangers of such essentializing, both in the past and the present. * Patrick Geary, Emeritus Professor of History, Institute for Advanced Study, Princeton New Jersey *Ancestry Reimagined does a brilliant job demystifying the pseudo-genetic personal histories that are being aggressively marketed to the public today. Ancestry is never composed of simply facts of nature, but is invariably the result of a complex negotiation between facts of nature and culture. And as millions of consumers purchase a bit of science in the hopes of constructing genetic identities for themselves, Kostas Kampourakis expertly and elegantly shows where the grains of salt must be taken each step of the way. * Jonathan Marks, Professor of Anthropology, UNC-Charlotte *Ancestry Reimagined provides an in-depth analysis of the geneticization of identity and ancestry. It grapples with how ancestry companies view race and ethnicity as somehow essential elements, written into our DNA. It is a unique and timely exploration that brings science to the study of the highly political topic of identity and genetic essentialisms. * Alan H. Goodman, Professor of Biological Anthropology, Hampshire College *In Ancestry Re-Imagined, Kostas Kampourakis offers a lucid explanation of the science behind DNA ancestry testing while exposing the circular reasoning and unrealistic assumptions that underpin the claim that one can "discover" one's ancestry through DNA test results. The result is a compelling demonstration that ethnicity is culturally constructed rather than genetically determined. * Jonathan M. Hall, Phyllis Fay Horton Distinguished Service Professor in the Humanities, University of Chicago, and author of Ethnic Identity in Greek Antiquity *Ancestry Reimagined succeeds in dismantling myths around genetic ancestry and provides an accessible and engaging and integrative discussion of a wide-ranging literature. It would serve as an excellent primer text for undergraduate students, scholars who are adjacent to, but still outside of, genetics, or the general public trying to make sense of their consumer genetics results. * Kevin A. Bird, Department of Plant Sciences, University of California-Davis, Davis, California, USA *Dr Kampourakis is adept at explaining philosophical concepts around biology and identity clearly and engagingly. For readers with a background in biosciences or genetics, I would highly recommend Ancestry Reimagined as a first step into considering the context and wider interpretations around our work. The book raises important questions around how ethnicity is linked to genetics beyond the commercial tests and throughout medical research. * Tom Turner, BioNews *Table of ContentsPreface Chapter 1 DNA ancestry testing: what it is and what people make of it Chapter 2 Essentializing social groups: nations Chapter 3 From race to ethnicity in ancestry testing Chapter 4 Genealogical and genetic ancestry Chapter 5 Using DNA ancestry evidence to retrace history Chapter 6 We are all Africans, ultimately Chapter 7 More related than distinct Chapter 8 Social constructs vs. "natural order" Chapter 9 Separating DNA from culture Chapter 10 Finding meaning in our ancestry testing Conclusion

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Book SynopsisThe book provides a multidisciplinary and interdisciplinary discussion of the ethos and ethics of precision/personal medicine, involving scientists who have shaped the field, in dialogue with ethicists, social scientists and philosophers of science.

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Book SynopsisBioinformatics covers practical important topics in the analysis of protein sequences and structures. It includes comparing amino acid sequences to structures comparing structures to each other, searching information on entire protein families as well as searching with single sequences, how to use the Internet and how to set up and use the SRS molecular biology database management system. Finally, there are chapters on multiple sequence alignment and protein secondary structure prediction. Bioinformatics will be invaluable to occasional users of these techniques as well as experienced professionals or researchers.Trade Review"a worthwhile addition to your library"R * Briefings in Bioformatics *Table of ContentsThreading Methods for Protein Structure Prediction ; Comparison of Protein Three-Dimensional Structure ; Multiple Alignments for Structural, Functional or Phylolgenetic Analyses of Homologous Sequences ; Hidden Markov Models for Data Base Similarity Searches ; Protein Family-Based methods for Homology Detection and Analysis ; Predicting Secondary Structure from Protein Sequences ; Methods for Discovering Conserved Patterns in Protein Sequences and Structures ; Comparison of Protein Sequences and Practical Database Searching ; Networking for the Biologist ; SRS - Access to Molecular Biological Databanks and Integrated Data Analysis

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Book SynopsisThe versatile RNA molecule, along with its many forms and functions, is elegantly captured in this succinct undergraduate text. Molecular Biology of RNA describes how RNA is not only an intrinsic part of the 'central dogma' of molecular biology, but also plays a part in processes as diverse as the regulation of gene expression and catalysis.Trade ReviewReview from previous edition Highly detailed, and well illustrated, ^Molecular Biology of RNA represents the first text to address exclusively the role of RNA in biological systems. * Kevin Coward in Journal of Biological Education, 2012 *This comprehensive textbook is pitched at just the right level and explains the concepts in sufficient detail to make them come to life. * Ilan Davis in Development, 2011 *Table of Contents1. Introduction to Molecular Biology of RNA ; 2. RNA can form versatile structures ; 3. Catalytic RNAs ; 4. The RNA-binding proteins ; 5. Pre-mRNA splicing by the spliceosome ; 6. Regulated alternative splicing ; 7. Pre-mRNA splicing defects in development and disease ; 8. Co-transcriptional pre-mRNA processing ; 9. Nucleocytoplasmic traffic of messenger RNA ; 10. Messenger RNA localization ; 11. Translation of messenger RNA ; 12. Stability and degradation of mRNA ; 13. RNA editing ; 14. The biogenesis and nucleocytoplasmic traffic of non-coding RNAs ; 15. The 'macro' RNAs: long non-coding RNAs and epigenetics ; 16. The short non-coding RNAs and gene silencing ; 17. RNA biology: future perspectives

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Book SynopsisOffers an account of the genomic revolution and its promise. This book provides a history of the science of genetics and genomics, from Mendel to Watson and Crick up to Craig Venter. It delves into the use of genomics in determining evolutionary paths - and what it can tell us, about how far we really have come from our ape ancestors.Trade Review"What is novel about Genomes and What to Make of Them is the impressive scope of the project, which covers key issues around the politics of genomics in an accessible way, taking care to outline in clear language some very complex scientific arguments in a way that allows the authors to deconstruct various arguments about the risks and opportunities of genomics. I know of no other book that captures the social implications of genomics in quite such a comprehensive and accessible yet insightful manner." - Peter Robbins, Open University"

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Book SynopsisTrade Review"The chromosome is at least as powerful an icon of heredity as DNA but so far has not held a central place in the historiography of twentieth-century life sciences. [Heredity under the Microscope] sets this record straight by directing its lense on the cytogenetic study of human chromosomes and the many contexts in which chromosome images came to matter. It opens fascinating new perspectives on the 'century of the gene' that go far beyond the earlier focus on the history of classical and molecular genetics." * British Society for the History of Science *"Heredity under the Microscope presents an accurate and sweeping view of the role that cytogenetics played, not only in the history of science after World War II but also as the means by which the current molecular view of the human chromosome was achieved. . . . [de Chadarevian's] is the first story of human cytogenetics told from the historical point of view. . . . The discussions are broad and comprehensive, with careful attention to details. With a few exceptions, they present all the main events occurring in the era of cytogenetics. . . . What is most remarkable to this reviewer, is that the longest section of the book is the notes (67 pp.). This section documents the multitude of sources for what is written in the five chapters. De Chadarevian spoke with a horde of researchers and listened to a great number of interviews with relevant cytogeneticists, and refers to an enormous amount of printed material. Everything in the five chapters is more than adequately supported, and the notes are a delight to read. . . . She deserves our thanks for putting together such a comprehensive survey of human cytogenetics." * FASEB Journal *"A fascinating read on the development of postwar human genetics. . . . This highly readable and impressive book demonstrates the overlapping concerns of science, medicine, law, and policy in the atomic age. De Chadarevian argues that the earlier microscopic research was central to the approach to studying human genetics. This book is a richly sourced survey of human cytogenetics and would be useful for undergraduate teaching." * Journal of the History of Ideas blog * "De Chadarevian's book fully meets its main goal: that of reintroducing chromosomes and cytogenetics into a still simplistic narrative of the history of the understanding of human heredity that traverses the twentieth century. . . . It is a most welcome development in the history of biology." * H-Sci-Med-Tech *"Images of the human chromosomes have enchanted scientists, inspired artists, and become symbols of human difference and pathology. In her engaging account, Soraya de Chadarevian deftly explores the visualization of these cellular 'colored bodies' and demonstrates their critical role in modern biology. The 'molecular revolution,' she suggests, was also a chromosomal revolution." -- M. Susan Lindee, University of Pennsylvania"De Chadarevian shows how much we have missed by looking at the history of biology since World War II as largely a history of how molecular geneticists cracked the genetic code. By focusing the lens on chromosomes, and their uses inside and outside the laboratory, her thorough yet elegant account exposes unexpected continuities, both with the eugenic past of heredity research and its genomic present." -- Staffan Müller-Wille, coauthor of The Gene: From Genetics to Postgenomics"Here we see most vividly how researchers debated the meanings and validity of visual evidence. Heredity Under the Microscope is a remarkable account of what was at stake in visualizing chromosomes." * Journal of the History of Biology *"The book is interesting, informative, and meticulously researched—a must-read for scientists and science studies scholars interested in the history of twentieth-century genetics. Chadarevian’s writing style is accessible and engaging, which also makes the book suitable for nonacademics. The argument, spread over five chapters, is nuanced and compelling." * Isis *Table of ContentsIntroduction 1. Radiation and Mutation 2. Chromosomes and the Clinic 3. X and Y 4. Scaling Up 5. Of Chromosomes and DNA Epilogue Acknowledgments Note on Sources Notes Bibliography Index

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