Genetics (non-medical) Books
World Scientific Publishing Co Pte Ltd Computational Biology And Genome Informatics
Book SynopsisThis book contains articles written by experts on a wide range of topics that are associated with the analysis and management of biological information at the molecular level. It contains chapters on RNA and protein structure analysis, DNA computing, sequence mapping, genome comparison, gene expression data mining, metabolic network modeling, and phyloinformatics.The important work of some representative researchers in bioinformatics is brought together for the first time in one volume. The topic is treated in depth and is related to, where applicable, other emerging technologies such as data mining and visualization. The goal of the book is to introduce readers to the principle techniques of bioinformatics in the hope that they will build on them to make new discoveries of their own.Table of ContentsExploring RNA Intermediate Conformations with the Massively Parallel Genetic Algorithm (B A Shapiro et al.); Introduction to Self-Assembling DNA Nanostructures for Computation and Nanofabrication (T H LaBean); Mapping Sequence to Rice FPC (C Soderlund et al.); Graph Theoretic Sequence Clustering Algorithms and Their Applications to Genome Comparison (S Kim); The Protein Information Resource for Functional Genomics and Proteomics (C H Wu); High-Grade Ore for Data Mining in 3d Structures (J S Richardson & D C Richardson); Protein Classification: A Geometric Hashing Approach (X Wang & J T L Wang); Interrelated Clustering: An Approach for Gene Expression Data Analysis (C Tang et al.); Creating Metabolic Network Models Using Text Mining and Expert Knowledge (J A Dickerson et al.); Phyloinformatics and Tree Networks (W H Piel).
£78.85
World Scientific Publishing Co Pte Ltd Practical Bioinformatician, The
Book SynopsisComputer scientists have increasingly been enlisted as “bioinformaticians” to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics:• Overview of modern molecular biology and a broad spectrum of techniques from computer science — data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc.• In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences.• Incisive discussion of computational prediction of secondary structure of RNA sequences.• Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function.• Overview of methods for discovering protein-protein interactions.• Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions.• Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.
£146.70
World Scientific Publishing Co Pte Ltd Genes, Mind, And Culture - The Coevolutionary
Book SynopsisLong considered one of the most provocative and demanding major works on human sociobiology, Genes, Mind, and Culture introduces the concept of gene-culture coevolution. It has been out of print for several years, and in this volume Lumsden and Wilson provide a much needed facsimile edition of their original work, together with a major review of progress in the discipline during the ensuing quarter century. They argue compellingly that human nature is neither arbitrary nor predetermined, and identify mechanisms that energize the upward translation from genes to culture. The authors also assess the properties of genetic evolution of mind within emergent cultural patterns. Lumsden and Wilson explore the rich and sophisticated data of developmental psychology and cognitive science in a fashion that, for the first time, aligns these disciplines with human sociobiology. The authors also draw on population genetics, cultural anthropology, and mathematical physics to set human sociobiology on a predictive base, and so trace the main steps that lead from the genes through human consciousness to culture.Table of Contents# The Next Synthesis: 25 Years of Genes, Mind, and Culture # The Primary Epigenetic Rules # The Secondary Epigenetic Rules # Gene-Culture Translation # The Gene-Culture Adaptive Landscape # The Coevolutionary Circuit # The Biogeography of the Mind # Gene-Culture Coevolution and Social Theory
£134.10
World Scientific Publishing Co Pte Ltd Advanced Analysis Of Gene Expression Microarray
Book SynopsisThis book focuses on the development and application of the latest advanced data mining, machine learning, and visualization techniques for the identification of interesting, significant, and novel patterns in gene expression microarray data.Biomedical researchers will find this book invaluable for learning the cutting-edge methods for analyzing gene expression microarray data. Specifically, the coverage includes the following state-of-the-art methods:• Gene-based analysis: the latest novel clustering algorithms to identify co-expressed genes and coherent patterns in gene expression microarray data sets• Sample-based analysis: supervised and unsupervised methods for the reduction of the gene dimensionality to select significant genes. A series of approaches to disease classification and discovery are also described• Pattern-based analysis: methods for ascertaining the relationship between (subsets of) genes and (subsets of) samples. Various novel pattern-based clustering algorithms to find the coherent patterns embedded in the sub-attribute spaces are discussed• Visualization tools: various methods for gene expression data visualization. The visualization process is intended to transform the gene expression data set from high-dimensional space into a more easily understood two- or three-dimensional space.
£76.95
World Scientific Publishing Co Pte Ltd Practical Bioinformatician, The
Book SynopsisComputer scientists have increasingly been enlisted as “bioinformaticians” to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics:• Overview of modern molecular biology and a broad spectrum of techniques from computer science — data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc.• In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences.• Incisive discussion of computational prediction of secondary structure of RNA sequences.• Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function.• Overview of methods for discovering protein-protein interactions.• Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions.• Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.
£85.50
World Scientific Publishing Co Pte Ltd Pooling Designs And Nonadaptive Group Testing:
Book SynopsisPooling designs have been widely used in various aspects of DNA sequencing. In biological applications, the well-studied mathematical problem called “group testing” shifts its focus to nonadaptive algorithms while the focus of traditional group testing is on sequential algorithms. Biological applications also bring forth new models not previously considered, such as the error-tolerant model, the complex model, and the inhibitor model. This book is the first attempt to collect all the significant research on pooling designs in one convenient place.The coverage includes many real biological applications such as clone library screening, contig sequencing, exon boundary finding and protein-protein interaction detecting and introduces the mathematics behind it.Table of Contentsd-Disjunct Matrices and d-Separable Matrices; Geometric and Algebraic Designs; Random Designs; Subset-Containment Designs; Array and Transversal Designs; The Complex Model; The Inhibitor Model; Contig Sequencing; Gene Detection.
£101.70
World Scientific Publishing Co Pte Ltd Understanding Genes And Gmos
Book SynopsisThe rapid progress in genomics and related technologies has increased interest in genetically modified organisms (GMOs). This concise and highly readable book equips the reader with essential information about what genes are, how they work, and how they can be modified and used in biotechnology. The book starts with a summary of the beginnings of life, the structure and components of living organisms, and an outline of genetic engineering.The coverage of human genetics spans race, human evolution and migration, the sex chromosomes, gene therapy, and forensic science. A separate chapter is devoted to the genetics and evolution of some of the major disease-causing organisms. On environmental genetics, the book considers the risks of releasing agricultural GM plants, as well as bioremediation and metal extraction by GM plants. Applications of genetic modification in agriculture — pest-resistant plants, herbicide resistance, and improved foods — are presented as part of a discussion on sustainable agriculture to emphasize the role played by GM plants in relation to chemicals, analytic techniques, and organic farming.Table of ContentsGetting Started; Life: Cells, Organisms and Evolution; How Biological Molecules Are Put Together; What Is a Gene?; How Do Genes Work?; Genetic Engineering; DNA Amplification and Analysis; Genes in the Natural World; People and Our Genes; Genetics of Some of Our Pathogens; Biotechnology and Sustainable Agriculture; GMOs in Agriculture; Patents, Regulations and the Future.
£45.60
World Scientific Publishing Co Pte Ltd Structural Proteomics And Its Impact On The Life
Book SynopsisThe role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, protein-protein complexes and protein-drug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact on such disciplines as neurobiology, developmental biology, immunology and molecular medicine.This book presents a state-of-the-art overview of the structural proteomics field, ranging from policy issues related to funding and goals, through the high-throughput procedures for protein production, to the solution of the structures of proteins and higher-order entities, via a multidisciplinary approach involving molecular biology, X-ray crystallography, NMR and electron microscopy, as well as bioinformatics analysis. This is the first book to provide such a comprehensive coverage of a rapidly evolving field.Table of ContentsIntrinsically Disordered Proteins (P Tompa); Impact of Structural Proteomics on Protein Crystallography (A Joachimiak); NMR in Structural Proteomics (R Kaptein & G Montelione); The Contribution of Structural Proteomics to Understanding the Function of Hypothetical Proteins (M D Suits et al.); Impact of SP on CASP and Vice Versa (J Moult); The Impact of 3D Structures on a Protein KnowledgeBase. From Proteins to Systems (U Hinz & A Bairoch); The Impact of Structural Proteomics on Macromolecular Structure Databases (D Dimitropoulos et al.); SP of Metalloproteins (M Edelman & V Sobolev); Impact of Protein Expression Methodologies on SP (D Hart); Bioinformatics and SP (A Lesk); Cryo-Electron Microscopy in the Era of Structural Proteomics (A C Steven & D M Belnap); SP of Complexes (T Perakis & C Romier); Structural Proteomics of Emerging Pathogens (R Hilgenfeld et al.); Strategies in SP (R Stevens); Impact of Structural Proteomics on Prediction of Protein-Protein Interactions (C Kiel & L Serrano); SP and Drug Design (Y-P Pang); SP in Relation to Signaling Pathways (D Moras); Policies in Structural Genomics/Structural Proteomics (J Norvell et al.).
£171.00
World Scientific Publishing Co Pte Ltd Dna Microarray Technology And Data Analysis In
Book SynopsisDNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology.Table of ContentsDNA Microarray Technique; Current Analytical Methods of DNA Microarray Data; Advantages and Disadvantages; Current Application of DNA Microarray Technique in Medicine; A Novel Method for DNA Microarray Data Analysis; Future Directions.
£76.95
World Scientific Publishing Co Pte Ltd Praise Of Chromosome Folly : Confessions Of An
Book SynopsisWhen examined carefully at the molecular level, the chromosome turns out to have created its own private world full of tricks, back door exits and novel solutions. This “folly” makes it an untamed innovator. Geneticists have been bewildered for decades. What kind of creature was actually the chromosome? Was it plastic, changing by innumerous rearrangements and mutations all the time; or was it a rigid structure which has preserved its basic organisation and functions since the dawn of the cell? It is this conflicting state that seems to be at the base of its “folly”. Perplexed by this behavior, cell biologists have called it a junkyard and even the ultimate parasite. Moreover, the chromosome has been regarded as a passive cell organelle prone to random mutations and subjected to the mercy of selection.The latest molecular information discloses a radically different picture in which the chromosome appears as an independent molecular structure that follows its own path. It does not obey gravity, randomness, selection or magnetism.By anchoring the chromosome's contradictory behavior on molecular processes directed by atomic self-assembly, Lima-de-Faria expands a novel view of the chromosome with unexpected implications for genetics, evolution and physics.This timely book contains the latest information on the molecular organization of the chromosome. The information is original and is presented in an unorthodox way, while carefully chosen elucidating and attractive figures serve to add clarity to the subject treated. Thus, the book will add greatly to the general debate on the evolution of living organisms, and will be of particular interest to those in the biotechnological field.
£42.75
World Scientific Publishing Co Pte Ltd From Genetics To Mathematics
Book SynopsisThis volume contains pedagogical and elementary introductions to genetics for mathematicians and physicists as well as to mathematical models and techniques of population dynamics. It also offers a physicist's perspective on modeling biological processes.Each chapter starts with an overview followed by the recent results obtained by authors. Lectures are self-contained and are devoted to various phenomena such as the evolution of the genetic code and genomes, age-structured populations, demography, sympatric speciation, the Penna model, Lotka-Volterra and other predator-prey models, evolutionary models of ecosystems, extinctions of species, and the origin and development of language. Authors analyze their models from the computational and mathematical points of view.Table of ContentsPreface; To Understand Nature - Computer Modeling Between Genetics and Evolution; Evolution of the Age-Structured Populations and Demography; Darwinian Purifying Selection versus Complementing Strategy in Monte-Carlo Simulations; Models of Population Dynamics and Their Applications in Genetics; Computational Modeling of Evolution: Ecosystems and Language; Age-Structured Population Models with Genetics.
£85.50
World Scientific Publishing Co Pte Ltd Quantitative Genetics And Its Connections With
Book SynopsisThe book gives an overview of developments in Quantitative Genetics and variance component analysis in an era of Big Data and Sequenced Genomes. It provides a detailed description of a direct method of estimation that will be a useful means of extracting information from a large set of data that was inconceivable 10 to 20 years ago.The book is a combination of a history of variance component analysis and a forward looking view as to how direct methods of estimation arise from the availability of big data sets and sequenced genomes of each individual in the sample.Many papers and books on quantitative genetics versions of the general linear model from statistics are useful for analyzing the data, using relatively small sets of data. In this book, new methods of direct estimation are introduced and analyzed that are appropriate for an era of big sets of data and sequences genomes. These direct methods of estimation are based on taking conditional expectations rather the methods of least squares that characterize many applications of the general linear model of statistics.
£53.20
World Scientific Publishing Co Pte Ltd Quantitative Genetics And Its Connections With
Book SynopsisThe book gives an overview of developments in Quantitative Genetics and variance component analysis in an era of Big Data and Sequenced Genomes. It provides a detailed description of a direct method of estimation that will be a useful means of extracting information from a large set of data that was inconceivable 10 to 20 years ago.The book is a combination of a history of variance component analysis and a forward looking view as to how direct methods of estimation arise from the availability of big data sets and sequenced genomes of each individual in the sample.Many papers and books on quantitative genetics versions of the general linear model from statistics are useful for analyzing the data, using relatively small sets of data. In this book, new methods of direct estimation are introduced and analyzed that are appropriate for an era of big sets of data and sequences genomes. These direct methods of estimation are based on taking conditional expectations rather the methods of least squares that characterize many applications of the general linear model of statistics.
£28.50
World Scientific Publishing Co Pte Ltd Nutrition, Epigenetics And Health
Book SynopsisEpigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.
£82.65
World Scientific Publishing Co Pte Ltd Life Of Professor Robert Hugh Pritchard, The: The
Book SynopsisColleagues and former students of the late Professor Pritchard (aka Bob), an eminent UK geneticist, have gathered memories about his scientific and personal life. Bob's early, crucial contributions to decipher gene structure and mechanism of recombination in fungi, and those in bacterial physiology and the cell cycle, are briefly summarized. Bob was appointed as a young professor (34 years old) to open a new Department of Genetics at the University of Leicester, a department that thrived under his leadership to become internationally recognized for the quality of its scientific research and teaching. Pritchard's research studies on Microbial Genetics and Physiology and his intellectual leadership were pioneering and instrumental in the development of Molecular Biology and Bacterial Cell Biology.Recollections from the contributors about their interactions with Bob will be enjoyed by anyone interested in the history of Genetics in the UK, during the 1960s and 1970s. To future generations of investigators, they provide insights into how unbiased honesty, humbleness, incisiveness, generosity and friendship are cornerstones for the advancement of human knowledge.The book has been compiled from articles by 26 colleagues, former students and friends of Bob Pritchard, and of his surviving daughter, each from his/her personal viewpoint. They include 17 Professors, 2 Readers, 4 Doctors (all PhD's), 2 politicians and an Attorney, and are citizens of 6 countries (UK-14, USA-5, FR-3, ES-2, IL-1, AU-1). Each chapter has been written independently of the others hence marked differences in length (between 1-10 pp) and style. The 44 photographs were gathered from their personal collections.
£53.20
World Scientific Publishing Co Pte Ltd Life Of Professor Robert Hugh Pritchard, The: The
Book SynopsisColleagues and former students of the late Professor Pritchard (aka Bob), an eminent UK geneticist, have gathered memories about his scientific and personal life. Bob's early, crucial contributions to decipher gene structure and mechanism of recombination in fungi, and those in bacterial physiology and the cell cycle, are briefly summarized. Bob was appointed as a young professor (34 years old) to open a new Department of Genetics at the University of Leicester, a department that thrived under his leadership to become internationally recognized for the quality of its scientific research and teaching. Pritchard's research studies on Microbial Genetics and Physiology and his intellectual leadership were pioneering and instrumental in the development of Molecular Biology and Bacterial Cell Biology.Recollections from the contributors about their interactions with Bob will be enjoyed by anyone interested in the history of Genetics in the UK, during the 1960s and 1970s. To future generations of investigators, they provide insights into how unbiased honesty, humbleness, incisiveness, generosity and friendship are cornerstones for the advancement of human knowledge.The book has been compiled from articles by 26 colleagues, former students and friends of Bob Pritchard, and of his surviving daughter, each from his/her personal viewpoint. They include 17 Professors, 2 Readers, 4 Doctors (all PhD's), 2 politicians and an Attorney, and are citizens of 6 countries (UK-14, USA-5, FR-3, ES-2, IL-1, AU-1). Each chapter has been written independently of the others hence marked differences in length (between 1-10 pp) and style. The 44 photographs were gathered from their personal collections.
£26.60
World Scientific Publishing Co Pte Ltd Biocomputing 2017 - Proceedings Of The Pacific
Book SynopsisThe Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
£189.00
World Scientific Publishing Co Pte Ltd Periodic Tables Unifying Living Organisms At The
Book SynopsisThe DNA sequencing of a series of living organisms has elucidated many biological problems. But the internal atomic and electronic evolution of DNA remains to be mapped in detail. RNA and DNA now appear to be the prime determinants of biological evolution leading to the sudden appearance of novel organism structures and functions that emerge 'ready made' as a surprise to the organism. This has been demonstrated by the manipulation of genes that led to the sudden production of additional complete wings and legs in flies and birds. The study of this internal atomic construction of macromolecules is being investigated at the large electron accelerators such as the MAX IV Synchrotron Radiation Laboratory, Lund University, Sweden.The periodicity of the chemical elements is well known from its iconic Table. Significantly, this periodicity can now be seen to extend to the properties of living organisms. Biological properties as different as: flight, vision, luminescence and regeneration, as well as others, show unexpectedly periodic emergence. They resurface, without previous announcement, in most unrelated plant and animal families and they emerge irrespective of whether the organism is a simple invertebrate or a most complex mammal.Moreover, this periodicity does not necessarily start at the cell or DNA levels but appears initially in crystals and minerals, where it is shown to be a pure atomic and electronic process, e.g. in luminescence and regeneration.The assembled molecular evidence led to the construction of Periodic Tables of living organisms, placing them in a position comparable to the periodicity of the chemical elements. Surprisingly, there are striking resemblances between the periodicities of the chemical elements and those of living organisms. In addition, the two types of Tables increase our insight into the events directing atomic evolution since the periodic law established in chemical elements turns out to be applicable to the periodicity of living organisms. The new Periodic Tables introduce a predictive capacity in biological evolution that before was hardly contemplated.Eric Scerri, from the Department of Chemistry and Biochemistry, California University, Los Angeles, who is the Author of the book 'The Periodic Table. Its Story and its Significance', Oxford University Press, stated in an e-mail that 'Professor Lima-de-Faria's book is wonderful and a pioneering work'.
£47.50
World Scientific Publishing Co Pte Ltd Nanopore Sequencing: An Introduction
Book SynopsisThis is an introductory text and laboratory manual to be used primarily in undergraduate courses. It is also useful for graduate students and research scientists who require an introduction to the theory and methods of nanopore sequencing. The book has clear explanations of the principles of this emerging technology, together with instructional material written by experts that describes how to use a MinION nanopore instrument for sequencing in research or the classroom.At Harvard University the book serves as a textbook and lab manual for a university laboratory course designed to intensify the intellectual experience of incoming undergraduates while exploring biology as a field of concentration. Nanopore sequencing is an ideal topic as a path to encourage students about the range of courses they will take in Biology by pre-emptively addressing the complaint about having to take a course in Physics or Maths while majoring in Biology. The book addresses this complaint by concretely demonstrating the range of topics — from electricity to biochemistry, protein structure, molecular engineering, and informatics — that a student will have to master in subsequent courses if he or she is to become a scientist who truly understands what his or her biology instrument is measuring when investigating biological phenomena.
£85.50
World Scientific Publishing Co Pte Ltd Learning About Your Genes: A Primer For
Book SynopsisGenes were unknowingly discovered in the 19th century by Gregor Mendel, a Czechoslovakian monk. It was later established that genes are made of DNA, a biological compound found in tiny thread-like structures called chromosomes that are located in the nuclei of all cells in our bodies. DNA consists of chains of entities called bases of which there are four in nature. DNA consists of long chains of bases (sometimes referred to as DNA sequences) that are joined in any order, but the precise order and length of which constitute different genes.Many (but not all) genes carry a code called the genetic code, a code that instructs the synthesis (manufacture) of the many hundreds of proteins that we require to survive and execute the many functions of life. The genetic code was deciphered in relatively recent years and is considered one of the most significant discoveries in the history of biology.Genes that encode instructions for the synthesis of proteins and those that regulate the manufacture of proteins comprise a mere two percent of our DNA. Despite our extensive knowledge of biology and the sub-discipline of molecular biology (the study of biology at the molecular level), the function (if any) of the rest of the DNA in our cells is unknown.Research about genes and DNA has in recent years spawned an endeavor referred to as the Human Genome Project, an international collaboration that has successfully determined, stored, and rendered publicly available the sequences of almost all the genetic content of the chromosomes of the human organism, otherwise known as the human genome.DNA sequences that are unique to every person on earth have been discovered (DNA fingherprints) and are now used for identifying criminals. The book relates a specific example of identifying a criminal who murdered two women.This is the first and only book that we are aware of that educates non-biologists about genes. It is written in a style and uses a vocabulary that can be comprehended by the average reader who knows very little if anything about genes.
£42.75
World Scientific Publishing Co Pte Ltd Understand Your Dna: A Guide
Book SynopsisAre you considering to test your own DNA? Do you want to learn more about your health and ancestry? Understand your DNA — A Guide is about what you can use genetics for. For a few hundred dollars, you can now scan your own genes. Millions of people all over the world have already done so. Everyone wants to see what they can get to know about themselves, and the market growing rapidly. But what does it require from you? And what can you really use a DNA test for? Understand your DNA — A Guide helps you put the plots and charts of consumer genetics into perspective and enables you to figure out what's up and down in the media headlines. The book is also a key input for today's debate about what we as a society can and want to do with medical genetics. Genetics will play a growing role in the future. Understand your DNA — A Guide is an easy-to-read and necessary guide to that future. The book is provided with a foreword by Professor Sham Pak-Chung of Hong Kong University.While there are many books about genetics, they typically take the perspective of a scientist wanting to understand the molecular levels. At the same time, direct-to-consumer genetics is a booming market, with millions of people already tested. Very little has been published that will guide them for real, because the need here is more focused on medical and practical understanding, than focussed on molecules.This book therefore aims to hit that vacant spot in the market. It's a walk-through of all concepts that are necessary to understand in your own analysis. Meanwhile, it is also limited in scope to only those concepts — thus distinguishing it from broader works.The book is appropriate for the readerships in modern multi-ethnic metropolises because it mixes European and Asian examples, both from the collaboration between the author from Europe and the foreword-writer, Prof. Pak Sham of Hong Kong University. But also, because many of the examples in the book concerns differences and similarities between Asian and European ethnicities, something the author believes is a trend in time.Related Link(s)
£52.25
World Scientific Publishing Co Pte Ltd Pathological Specimens And Genomic Medicine:
Book SynopsisPathological Specimens and Genomic Medicine — Emerging Issues surveys various fields and medical disciplines related to the implementation of the new field of genomic medicine. The book includes sections on specimen processing, the effects of tissue fixation and storage impact on downstream molecular assays, image analysis and its role in the pathology workflow, molecular evaluation of samples, and how to present data to clinicians. The book contains examples of cases where these innovative technologies are applied in the real world, and also presents a look in to the future of the field of genomic medicine.
£121.50
Pan Stanford Publishing Pte Ltd Cap-Analysis Gene Expression (CAGE): The Science
Book SynopsisThis book is a guide for users of new technologies, as it includes accurately proven protocols, allowing readers to prepare their samples for experiments. Additionally, it is a guide for the bioinformatics tools that are available for the analysis of the obtained tags, including the design of the software, the sources and the Web. Finally, the book provides examples of the application of these technologies to identify promoters, annotate genomes, identify new RNAs and reconstruct models of transcriptional control. Although examples mainly concern mammalians, the discussion expands to other groups of eukaryotes, where these approaches are complementing genome sequencing.Trade Review"This is a comprehensive introduction to a powerful and important new technique that is transforming our understanding of gene regulation. This volume contains everything you need to know to become an expert in CAGE, from library construction to bioinformatic analysis of the voluminous data sets."—Gene E. Robinson, University of IllinoisTable of ContentsBrief Historical Perspective on Transcriptional Regulation. Preparation of CAGE Libraries: An Enabling Experimental Protocol. Ditags and PET-Technologies for Transcript Identification and Review Use of Ditags with Emphasis on Gene Identification. From Sequencing Output to CAGE Tags: A Chapter on the Extraction of CAGE Tags from the Raw Output of the Sequencing Machine. Using CAGE Data for Quantitative Expression. Compare CAGE Expression to Microarrays and qPCR. Identification of Isoforms. Promoter Analysis Databases. Construction and Tutorial of the CAGE Analysis Viewer and Genome Viewer. Transcriptional Network Analysis Using CAGE. Biological Examples of Alternative TSS/Promoters. Challenges in CAGE Analysis.
£108.00
Pan Stanford Publishing Pte Ltd MicroRNA Profiling in Cancer: A Bioinformatics
Book SynopsisThis book presents advances in the interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. It discusses interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation.Trade Review"Topics on microRNAs have taken scientists by storm in the last seven years. Today more than 5500 publications related to microRNAs can be found in PubMed. Do we really need another book for readers already saturated with this topic? The answer is a definite yes. Yuriy Gusev has wisely put together a fine book linking various aspects of the study of microRNAs starting with profiling of microRNoma, the functional study of pathway networks involving miRNAs as well as evolutionary models of microRNoma evolution or mathematical models of posttranscriptional regulation of microRNAs. Readers will find the book different compared with others already published. One thing is certain: the curiosity of the readers will increase with every page turned."—George A. Calin, MD Anderson Cancer CenterTable of ContentsMeasurement and Interpretation of MiRNA Expression Profiles. MicroRNA Expression Analysis by LNA Enhanced Microarrays. Analysis and QC for Real-Time QPCR Arrays of Human MicroRNAs. Massively Parallel MicroRNA Profiling in the Haematologic Malignancies. Who Dunit? MicroRNAs Involved in Prostate Cancer. Intronic MicroRNA. Creation, Evolution and Regulation. Mirome Architecture and Genomic Instability. Interconnection of MicroRNA and Transcription Factor-Mediated Regulatory Networks. Analysis of MicroRNA Profiling Data with Systems Biology Tools. Mathematical and Computational Modeling of Post-Transcriptional Gene Regulation by MicroRNAs.
£88.19
World Scientific Publishing Co Pte Ltd Live Imaging In Zebrafish: Insights Into
Book SynopsisThe zebrafish embryo has now been well established as an organism of choice for the genetic and cell biological basis of vertebrate development. Large-scale forward genetic screens together with reverse genetic tools have resulted in a flood of new information on the regulation of vertebrate development. Furthermore, the unique transparency of the zebrafish embryo allows unprecedented access to cells and tissues and many important discoveries on gene function have already been made using live imaging techniques in this organism. This book successfully brings together state-of-the-art methodologies of live imaging, such as the use of fluorescence correlation spectroscopy (FCS), that will be useful for investigators in the field of developmental biology to address their favorite problem using cell biological approaches in the zebrafishOne of the key reasons that has made the zebrafish such a popular vertebrate model is its transparency and its potential for high-resolution cell biology and imaging. However, there is no comprehensive and up-to-date guide to the new “live imaging” tools that can now be used in the zebrafish. Furthermore, there are many new microscopy methods that have been adapted for use in zebrafish, and this book can be a good guide even for scientists already familiar with the imaging advantages of this model.Table of ContentsImaging Neuronal Migration; Imaging the Peripheral Nervous System and Glia; Branchiomotor Neuron Migration; Fluorescence Correlation Spectroscopy; Imaging Digestive Physiology; Imaging Cells During Infection and Wound Healing;
£75.05
World Scientific Publishing Co Pte Ltd Systems Biology: Applications In Cancer-related
Book SynopsisThis volume presents an overview of recent developments in systems biology and their applications in cancer-related research. The ongoing advances in our understanding of genomics and proteomics, coupled with the development of new and more robust tools, have led to an emphasis on analyzing biological systems at multiple levels. Thus, there is a need to integrate different types of data into a comprehensive “systems” view.Written by active researchers in the emerging areas, this book gives senior undergraduate students, graduate students and new researchers an idea of where the frontiers of systems biology are and an opportunity to learn high-throughput techniques in use. One of the particular emphases of the book is to elucidate the molecular mechanisms in cancer. The discovery of biomarkers and anti-cancer drugs using systems biology approach is also extensively discussed.Table of ContentsGene/Protein Networks and Pathways: Introduction to Systems Biology; Gene Network Construction for Molecular Regulation; MicroRNA Regulated Cellular Networks in Cancer; Disease-related Modules in Protein Interaction Networks; Biomolecular Pathway Modeling; High-throughput Omics Data and Analysis: Methods and Systems for ChIP-seq Data Analysis; Discovery of Transcription Factor Binding Sites and Its Applications in Cancer Study; Cancer Epigenomics; Tools and Emerging Applications for Mining the Phosphoproteome in Cancer Biology; Predicting Cancer-Related MicroRNAs; MicroRNA Regulation: Databases and Tools; Applications for Biomarkers and Drug Discovery: Next-Generation Sequencing Technologies and Their Applications in Cancer Research; Membrane Proteomics for the Opportunity of Cancer Biomarker and Drug Target Discovery; Structure-Based Systems Biology and Drug Design in Cancer Research; Discovering Drug Targets for Cancer
£94.50
World Scientific Publishing Co Pte Ltd Advances In Genomic Sequence Analysis And Pattern
Book SynopsisMapping the genomic landscapes is one of the most exciting frontiers of science. We have the opportunity to reverse engineer the blueprints and the control systems of living organisms. Computational tools are key enablers in the deciphering process. This book provides an in-depth presentation of some of the important computational biology approaches to genomic sequence analysis. The first section of the book discusses methods for discovering patterns in DNA and RNA. This is followed by the second section that reflects on methods in various ways, including performance, usage and paradigms.Table of ContentsPattern Discovery Methods: Large-Scale Gene Regulatory Motif Discovery with NestedMICA (M Piipari et al.); R'MES: A Tool to Find Motifs with a Significantly Unexpected Frequency in Biological Sequences (S Schbath & M Hoebeke); An Intricate Mosaic of Genomic Patterns at Mid-range Scale (A Fedorov & L Fedorova); Motif Finding from Chips to ChIPs (G Pavesi); A New Approach to the Discovery of RNA Structural Elements in the Human Genome (L Hua et al.); Performance and Paradigms: Benchmarking of Methods for Motif Discovery in DNA (K Klepper et al.); Encyclopedias of DNA elements for Plant Genomes (J Lichtenberg et al.); Manycore High-Performance Computing in Bioinformatics (J-S Varre et al.); Natural Selection and the Genome (A L Hughes).
£82.65
World Scientific Publishing Co Pte Ltd Molecular Insights Into Development In Humans:
Book SynopsisThe aim and scope of this book is to review current information on human development and processes of differentiation that have benefited from breakthrough analyses in stem cell biology, elucidation of genome and gene architecture and aspects of regulation of gene expression, analysis of signaling systems and transcription factor actions.Insights into actions of specific genes and their roles in development have been gathered through studies in patients with specific birth defects, including congenital malformations, metabolic defects and functional impairments.The book is organized into three sections, the first dealing with aspects of genomics, gene structure and regulation, analysis of signaling and function of specific organelles. The second section deals with molecular aspects of development of specific organs and structures such as, bone, face, brain, heart, liver, pancreas, kidney. The last section deals with specific malformations and tumors that provide insight into regulation of growth. Environmental factors that impact growth and development are also covered.
£57.00
Pan Stanford Publishing Pte Ltd Cancer Genetics and Genomics for Personalized
Book SynopsisThis book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.Trade Review"Likely as the recent Cancer Moonshot Initiative highlights, this book well describes the importance of genetics/genomics-based personalized therapies to improve cancer treatments. This field is growing rapidly, and it is certain that many scientists should obtain professional knowledge of ‘cancer precision medicine’ to cure more cancer patients."—Prof. Yusuke Nakamura, University of Chicago, USA"At a time when an explosive increase in data has combined with rapidly evolving treatment paradigms, it has become particularly challenging for modern clinicians and medical researchers alike to put these advances in knowledge and practice into a proper context. It is in light of this predicament that this new volume edited by Dr. Il-Jin Kim provides a much-needed organization and harmonic understanding to the cacophony of information regarding the elusive realm of precision medicine. Covering an exhaustive array of topics ranging from the basic science of tumor modeling to the biology of tumor microenvironments to the horizon of cancer immunotherapy and advances for specific cancer types, this clearly written and very readable compilation provides a solid foundation for comprehending the rapidly advancing dawn of a truly new, personalized, precision approach to the treatment and, hopefully, the cure of cancer."—Prof. Michael J. Mann, University of California, San FranciscoTable of ContentsPersonalized Medicine for Cancer: Introduction and Overview of the Book. Personalized Medicine in Lung Cancer. Genome-Based Personalized Medicine in Liver Cancer. Applications of Circulating DNA Analysis in Personalized Medicine. Circulating Tumor Cells and Personalized Medicine. Mouse Models in Personalized Cancer Medicine. Tumor Microenvironment, Therapeutic Resistance, and Personalized Medicine. Personalized Immune Therapy. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Malignancies. Personalized Medicine in Hereditary Cancer Syndromes. Pathology in the Era of Personalized Medicine. MicroRNAs in Human Cancers. Pharmacogenomics of Tamoxifen.
£97.20
Springer Verlag, Singapore Methods in Cancer Stem Cell Biology
Book SynopsisThis book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters of this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. Table of Contents1. On the origin of cancer.- 2. Culture of Cells: Basic Principles .- 3. Stem cell culture from embryos.- 4. Reprogramming of normal cells.- 5. Maintenance of human Pluripotent Stem Cells.- 6. Identification of cancer stem cells by different molecular markers .- 7. Enrichment of Cancer Stem Cell from malignant tumor.- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line .- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells.- 10. Quick method to assess non-mutagenic carcinogens with iPS cells.- 11. Self-renewal potential of caner stem cells.- 12. Differentiation potential of cancer stem cells in vitro.- 13. Tumor Angiogenesis by cancer stem cells in vivo.- 14. Invasion and Metastatic potential of cancer stem cells in vitro.- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro .- 17. Tumorigenic potential of cancer stem cells in vivo.- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells .- 19. In-vitro evaluation of anti-cancer stem cell drugs .- 20. In vitro Tumoroid Model Using Cancer Stem Cells.
£98.99
Springer Verlag, Singapore Targeting Epigenetics in Inflammatory Lung
Book SynopsisThis book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.Table of ContentsChapter 1. Introduction to Lung Diseases.- Chapter 2. Introduction to Epigenetics.- Chapter 3._Epigenetic mechanisms in Inflammation.- Chapter 4. Epigenetic regulator of inflammatory gene expression.- Chapter 5. Epigenetics of Asthma.- Chapter 6_. Epigenetic optimization in chronic obstructive pulmonary disease (COPD.- Chapter 7. Epigenetics of Lung Cancer.- Chapter 8. Epigenetics of Pulmonary Tuberculosis.- Chapter 9. Epigenetics of Idiopathic Pulmonary Fibrosis.- Chapter 10. Epigenetics of influenza-A virus infection.- Chapter 11. Epigenetics of rhinovirus.- Chapter 12. Epigenetics of SARS-Cov2 (Covid-19).- Chapter 13. Epigenetics of Haemophilus Influenzae.- Chapter 14. Future Prospects and Challenges.- Chapter 15. Targeting epigenetics in pulmonary arterial hypertension.
£125.99
Da Kuai Wen Hua/ Tsai Fong Books Inheritance: How Our Genes Change Our Lives, and Our Lives Change Our Genes
£35.55
Nova Science Publishers Inc Transcriptomics and their Importance
Book Synopsis
£138.39
Oxbow Books The Late Minoan III Necropolis of Armenoi: Volume II - Biomolecular and Epigraphical Investigations
Book SynopsisThe Late Minoan III Necropolis of Armenoi, Crete (ca. 1390–1190 BC) is the only intact, complete Late Minoan necropolis presently known, of which 232 tombs have been excavated. The research project was the first large-scale genomic sampling of skeletal material from a single site in Bronze Age Greece, as well as being the first time a multi-disciplinary approach with ancient DNA as its focus has been conducted on a large, well-curated necropolis assemblage. As such it provides a unique opportunity to answer archaeological questions, the most important of which are kinship, an analysis of the origin and ancestry of those buried in the tombs, the homogeneity of the population or otherwise, and diet. The analysis programme was only possible because the tombs had not been seriously disturbed, and human skeletal remains had survived and been expertly conserved. The results of ancient DNA, stable isotope analysis, osteological analysis, and radiocarbon dating are presented, providing the first detailed record of ancestry and kinship in this iconic period of Eastern Mediterranean prehistory.In addition, the long-debated problem of the location of the wealthy city of da-*22-to, referred to many times in the Linear B tablets, is addressed and key evidence is presented. The rich finds in the Necropolis, the town excavation, and in the environs, support the interpretation that the ‘city’ that built the Necropolis is da-*22-to.Table of ContentsFigures and Tables Conventions and Abbreviations Chronology Acknowledgements Map of Site 1. Introduction 2. The Archaeology of the Late Minoan III Necropolis of Armenoi: an Introduction 3. The Bioarchaeological Analysis of Human and Faunal Skeletal Remains 4. Multi-isotopic Measurements of Human Remains at the Late Minoan III Necropolis of Armenoi 5. The Archaeological Significance of the DNA and Stable Isotope Results 6. The Identification of da-*22-to 7. The Archaeological Evidence which Supports the Identification of the Late Minoan III City of Armenoi as da-*22-to
£37.95
