Genetics (non-medical) Books

Book SynopsisLeading paleontologist J. David Archibald explores the rich history of visual metaphors for biological order from ancient times to the presentTrade ReviewJ. David Archibald is one of the leading paleomammalogists in the world, and one of the foremost experts on the biotic changes across the Cretaceous-Tertiary boundary. In this book, he shows a deep understanding of the chronology and iconography of the 'tree' as both an iconic metaphor and a conceptual device in the history of biology. -- Kevin Padian, University of California, Berkeley This book presents a fascinating trip through the history of imagery and conceptual frameworks used to understand the diversity and evolution of life. J. David Archibald has produced an authoritative and delightful text that will be relished by anyone interested in evolution, biodiversity, the history and philosophy of science, scientific art, or graphic design. -- David M. Hillis, University of Texas at Austin Through the long history of drawings and diagrams, J. David Archibald's magnificent new book shows us how people have depicted the diverse interrelated array of life: from linear chains and ladders up through modern evolutionary trees. Archibald's work makes it clear that these relationships have been sensed regardless of the competing ideas of how the patterns were formed: whether through supernatural causes or natural evolutionary processes. -- Niles Eldredge, author of Darwin: Discovering the Tree of Life Aristotle's Ladder, Darwin's Tree provides a fascinating insight into the way biologists use diagrams to show the history of evolution. David Archibald documents the story of these pictures in an engaging and refreshing style, ranging from beautiful early manuscripts and frescoes that display religious and human genealogical relationships, to the most modern phylogenetic trees that appear in scientific journals and textbooks. A great book for a biologist! -- Janet Browne, Harvard University Archibald's book is interdisciplinary, authoritative, well-written and complete, with a deep historiographic appreciation of its many subjects. Nature Aristotle's Ladder, Darwin's Tree will be intellectually stimulating for those interested in the history and philosophy of biology, and especially for those impressed by the importance of the visual for the construction of scientific knowledge. Reports of the National Center for Science Education Impressive and rather humbling... Cladistics Fascinating... A book that is very much worth reading by anyone who is interested in the conceptual heritage of phylogenetic trees. Systematic Biology Splendid... Aristotle's Ladder, Darwin's Tree is a wonderful book. Quarterly Review of Biology Illuminating... It has cross-disciplinary appeal, but will be more digestible to readers with prior knowledge of evolutionary theories. Journal of Historical Geography Rich in content, beautifully illustrated, and often thought-provoking, this book should be of interest to anyone interested in the history of visual representations in the life sciences... This is a book to think with. Archives of Natural History Incites curiosity. Journal of Vertebrate PaleontologyTable of ContentsPreface Acknowledgments 1. Blaming Aristotle 2. The Roots of the Tree of Life 3. Competing Visual Metaphors 4. Deciphering Darwin's Trees 5. The Gilded Age of Evolutionary Trees 6. The Waning and Waxing of Darwinian Trees 7. Three Revolutions in Tree Building 8. The Paragon of Animals References Index

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Book SynopsisThis book is indispensable for students working in a laboratory setting or studying free-ranging populations.Trade Review"John Gillespie has done the near-impossible, condensing the essence of population genetics into a very short book. The result is a little gem. The derivations are simple and clear, and often strikingly original. The minor gaps in the first edition are filled by this equally concise second edition. Population genetics is a complicated subject; only a person of Gillespie's depth of knowledge and insight could simplify without distorting." - James F. Crow, author of Genetics Notes "The book is coherently and logically structured and covers all the most important and incontrovertible aspects of population genetics... I recommend this as a good introductory book that can be used in both undergraduate and graduate courses." - Heredity "A well-developed, thoughtful, and classic book that has been tested and improved through many years in the classroom... A 'must' for anyone interested in plant or animal genetics." - Choice"Table of ContentsList of FiguresPrefaceChapter 1. Genetic VariationChapter 2. Genetic DriftChapter 3. Natural SelectionChapter 4. Two-Locus DynamicsChapter 5. Nonrandom MatingChapter 6. Quantitative GeneticsChapter 7. The Evolutionary Advantage of SexAppendix A. Mathematical NecessitiesAppendix B. ProbabilityBibliography Index

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Book SynopsisThe recent research into using the CRISPR gene-editing technology to change genetic coding in an organism’s DNA has generated tremendous public interest, but where is this technology going? In this issue of The Reference Shelf we look at gene editing and genetic engineering, drawing from periodicals, medical reports, and politics to see how this debate is progressing within popular culture. Issues investigated will include engineering new organisms, the potential for medical breakthroughs, the ethics of altering the human genome, and the campaign to bring back the dinosaurs.

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Book SynopsisThe Indo-European dispersal has puzzled scholars for centuries. When in prehistory did this dramatic linguistic shift take place and from where? What were the main driving forces? This books provides the newest insights from linguistics, archaeology and genetics on the prehistoric spread of one of the world's largest language families.Table of ContentsIntroduction: re-theorizing interdisciplinarity, and the relation between Archaeology, Linguistics, and Genetics Kristian Kristiansen and Guus Kroonen ; Part I. Early Indo-European and the Origin of Pastoralism: 1. The Yamnaya Culture and the invention of Nomadic pastoralism in the Eurasian steppes David W. Anthony; 2. Yamnaya pastoralists in the Eurasian desert steppe zone: new perspectives on mobility Natalia I. Shishlina; 3. Proto-Indo-Anatolian, the 'Anatolian Split' and the 'Anatolian Trek': a comparative linguistic perspective Alwin Kloekhorst; Part II. Migratory Processes and Linguistic Dispersals between Yamnaya and the Corded Ware: 4. The corded ware complex in Europe in light of current archeogenetic and environmental evidence Wolfgang Haak, Martin Furholt, Martin Sikora, Adam Ben Rohrlach, Luka Papa, Karl-Goran Siogren, Volker Heyd, Morten Fischer Mortensen, Anne Brigitte Nielsen, Johannes Muller, Ingo Feeser, Guss Kroonen and Kristian Kristiansen; 5. Emergent properties of the corded ware culture: an information approach Quentin Burgeois and Erik Kroon; 6. Linguistic phylogenetics and words for metals in Indo European Thomas Olander; 7. Word mining: metal names and the Indo-European dispersal Rasmus Thorso, Andrew Wigman, Anthony Jakob, Axel I. Palmer, Paulus Van Sluis and Guus Kroonen; Part III. The Cultural and Linguistic Significance of Bell Beakers Along the Atlantic Fringe: 8. From the steppe to Ireland: the Impact of a DNA research James P. Mallory; 9. Beaker culture metal and mobility in Atlantic Europe: some implications for genetic and language origins William O' Brien; 10. 'From the ends of the earth': a cross-disciplinary approach to long-distance contact in bronze age Atlantic Europe John T. Koch and Johan Ling; 11. With the back to the ocean: the Celtic maritime vocabulary David Stifter; 12. European prehistory between Celtic and Germanic: the Celto-Germanic isoglosses revisited Paulus Van Sluis, Anders Richardt Jorgensen and Guus Kroonen; Part IV. The Bronze Age Chariot and Wool Horizons: 13. Relative and absolute chronologies of the chariot complex in Northern Eurasia and early Indo-European migrations Igor V. Chechushkov and Andrey V. Epimakhov; 14. Indo-European and Indo-Iranian wagon terminology and the date of the Indo-Iranian split Alexander M. Lubotsky; 15. Fire and Water: archaeology and linguistics (The bronze age of the Southern Urals and the Rigveda) Andrey V. Epimakhov and Alexander M. Lubotsky; 16. Wool fibers of the Northern Eurasian bronze age: the cultural and geographical contexts Natalia I. Shishlina, Polina S. Medvedeva; Olga V. Orfinskaya and Daria V. Kiseleva; 17. An archaeolinguistic approach to Indo-European wool terminology Birgit A. Olsen; Part V. Kinship Systems, Marriage, Fosterage, Free and Unfree: 18. Mobility, kinship, and marriage in Indo-European society Tijmen Pronk; 19. Marriage strategies and fosterage among the Indo-Europeans- a linguistic perspective Birgit A. Olsen; 20. Fostering women and mobile children in final neolithic and early bronze age Central Europe Philipp W. Stockhammer; 21. Hiding in plain sight? The enigma of the linguistic remains of prehistoric slavery Benedicte Nielsen Whitehead; Part VI. Concluding Reflections: 22. New directions in archaeogenetics and archaeolinguistics: recapitulation and outlook Guss Kroonen and Kristian Kristiansen.

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Book SynopsisCovering a range of metaphors from a diverse field of sciences, from cell and molecular biology to evolution, ecology, and biomedicine, Understanding Metaphors in the Life Sciences explores the positive and negative implications of the widespread use of metaphors in the biological and life sciences. From genetic codes, programs, and blueprints, to cell factories, survival of the fittest, the tree of life, selfish genes, and ecological niches, to genome editing with CRISPR''s molecular scissors, metaphors are ubiquitous and vital components of the modern life sciences. But how exactly do metaphors help scientists to understand the objects they study? How can they mislead both scientists and laypeople alike? And what should we all understand about the implications of science''s reliance on metaphorical speech and thought for objective knowledge and adequate public policy informed by science? This book will literally help you to better understand the metaphorical dimensions of science.Trade Review'What a timely book this is! It is precisely because biology has made such striking advances in recent years that its stock of metaphors is due for a clinical check-up. Reynolds offers a reliable and perceptive diagnosis of the framing narratives of the life sciences, sympathetically examining their strengths and weaknesses. This book should be an essential accompaniment to any study course in the biological sciences.' Philip Ball, science writer and author of How to Grow a Human'In this beautifully written, highly accessible, and captivating work, Reynolds reveals the incredible extent to which scientific methods and descriptions in biology, the life sciences, and medicine are infused with metaphors. Interweaving the rich history and philosophy of the uses of these metaphors over time, their many implications for scientific reasoning, understanding, and the ethical and political dimensions of science itself are perceptively explored, with wonderful clarity and across an encyclopedic range of examples. Metaphors afford telling insight, opening doors to further inquiry and closing others. Is your genome software? Are enzymes molecular machines? Does nature select some traits over others, thereby constructing the tree of life? The fascinating world of metaphors in science comes to life on every page.' Anjan Chakravartty, University of Miami, USA'I read Lakoff and Johnson's book Metaphors We Live By in the 1980s, and it was eye opening. Andrew Reynolds' book, which should be called Metaphors Science Lives By, is equally eye opening. Metaphors shape the way we live in the world. In science, they shape the way we understand the world. This can have huge implications for our lives, for better or for worse. How does this process of understanding work, especially in the life sciences? This book deals with the essential role of metaphors in this process. Written in an admirably clear style, Reynolds makes us aware of the power of metaphor, but also its dangers and pitfalls. It is an essential read for everybody interested in understanding how science and science communication work with and through metaphors. Importantly, it also dispels some common misunderstandings about the role of metaphors in science.' Brigitte Nerlich, University of Nottingham, UK'Understanding Metaphors in the Life Sciences takes us from genes to cells, and up to the vast evolutionary tree of life, showing how science depends overwhelmingly on metaphor for understanding, for advance, for communication. A very important book.' Michael Ruse, Florida State University, USA'Philosophically illuminating and richly informative on genetics, evolution and ecology, it should be obligatory reading for students in both the humanities and the sciences.' Jane O'Grady, Literary Review'Clear and concise, the book has an immense didactic value and will serve as a precious teaching aid in history and philosophy classes. However, despite being intended as an entry-level text, the book is more than a synthetic introduction to the subject. Beyond the analysis and evaluation of some of the most iconic metaphors in the life sciences, Reynolds provides a unique perspective on their function and use.' Bartlomiej Swiatczak, Metascience'Philosophically illuminating and richly informative on genetics, evolution and ecology, it should be obligatory reading for students in both the humanities and the sciences.' Jane O'Grady, Literary ReviewTable of Contents1. Metaphors and science; 2. Background metaphors: agents, machines, and information; 3. Genes and genomes: agents, codes, programs, blueprints, and books; 4. Proteins: machines, messengers, and team players; 5. Cells: factories, computers, and social organisms; 6. Evolution: natural selection, the tree of life, and selfish genes; 7. Ecology: the balance of nature, niches, ecosystem health, and gaia; 8. Biomedicine: genetic engineering, genome editing, and cell reprogramming.

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Book Synopsis“Ridley leaps from chromosome to chromosome in a handy summation of our ever increasing understanding of the roles that genes play in disease, behavior, sexual differences, and even intelligence. . . . . He addresses not only the ethical quandaries faced by contemporary scientists but the reductionist danger in equating inheritability with inevitability.” — The New YorkerThe genome''s been mapped. But what does it mean? Matt Ridley’s Genome is the book that explains it all: what it is, how it works, and what it portends for the futureArguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest

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Book SynopsisSince their discovery by Barbara McClintock in the mid-20th century, the importance of transposable elements in shaping the architecture, function and evolution of genomes has gradually been unveiled. These DNA sequences populate nearly all genomes and are viewed as genomic parasites. They are mobile, capable of proliferating within genomes and also commonly travel between species. These elements are mutagenic and are responsible for several human genetic disorders, but they also constitute a major source of genetic diversity. Some insertions have beneficial effects for the host and are selected for, giving rise to significant evolutionary innovations. Their dynamics within genomes are intricate, as are their interactions with other genome components. To limit their proliferation, the genome has evolved sophisticated defense mechanisms. While researchers commonly use these elements as genetic tools, their identification in newly sequenced genomes remains a chall

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Book SynopsisFor a century, social scientists have avoided genetics like the plague. But the nature-nurture wars are over. In the past decade, a small but intrepid group of economists, political scientists, and sociologists have harnessed the genomics revolution to paint a more complete picture of human social life than ever before. The Genome Factor describesTrade Review"Too often, the debate over the ethics of genomics takes place behind closed doors--among scientists, doctors and government officials. Members of the general public are left out or treated as an afterthought rather than placed at the center of the conversation. Scientific research is crucial, but the moral dilemmas raised by The Genome Factor belong to us all."--Amy Dockser Marcus, Wall Street Journal "A fresh look at the nature vs. nurture debate... Illuminating."--KirkusTable of Contents1 Molecular Me: Welcome to the Coming Social Genomics Revolution 1 2 The Durability of Heritability: Genes and Inequality 12 3 If Heritability Is So High, Why Can't We Find It? 35 4 Genetic Sorting and Cavorting in American Society 60 5 Is Race Genetic? A New Take on the Most Fraught, Distracting, and Nonsensical Question in the World 84 6 The Wealth of Nations: Something in Our Genes? 113 7 The Environment Strikes Back: The Promise and Perils of Personalized Policy 136 CONCLUSION: Whither Genotocracy? 170 EPILOGUE: Genotocracy Rising, 2117 188 APPENDIX 1 196 APPENDIX 2 200 APPENDIX 3 204 APPENDIX 4 209 APPENDIX 5 219 APPENDIX 6 225 NOTES 233 INDEX 277

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Book SynopsisCole excavates the forgotten global history of criminal identificationfrom photography to exotic anthropometric systems based on measuring body parts, from fingerprinting to DNA typing. He reveals how fingerprinting ultimately won the trust of the public and the law after a long battle against rival identification systems.Trade ReviewFor most of the century since it made its courtroom debut, fingerprinting has enjoyed an impeccable reputation for identifying criminals. What jury would acquit a suspect if his prints matched those found at the scene of a crime? …Simon Cole…is one of a small group of people that has started looking at the technique which, above all others, gave forensic ‘science’ its scientific status. And, surprisingly, he has found it is scientifically and statistically wanting. * The Economist *For almost a century, fingerprinting remained one of the most respected tools of forensic science. Only in the early nineties did faith in its reliability begin to erode. In [Suspect Identities], Simon A. Cole recounts how a number of cases involving the New York State Police revealed tampering with fingerprint evidence, as well as the incompetence of many police labs. -- William Cohen * New Yorker *[A] fascinating, thought-provoking book. * Science *Simon A. Cole's well-written and interesting book is a cultural, social, and scientific history of fingerprint identification. It makes the intriguing argument that scientific merit had nothing to do with the acceptance of fingerprints as uniquely good identification evidence. -- Adina Schwartz * New York Law Journal *Cole's treatment of fingerprinting is...commendable...[He] shows that...court cases...were not quite as singular in ascendancy of fingerprinting over the Bertillon system, but rather added weights that finally tipped the scales in favor of fingerprinting; he is also cautionary about its claim to absolute reliability. * Booklist *Cole weaves the intriguing tale of how and why people were identified as who they claimed to be. This history begins in the era where identification was largely unnecessary because people did not travel very far and were known in their own communities. As both travel and criminal behavior increased, the need to identify people grew...Cole describes the ancient use of fingerprints up through time until they became commonplace for use in identifying criminals. He presents an excellent account of the problems and controversies surrounding the use of fingerprints for identification, ending with the current issues of using DNA for identification. The illustrative stories are excellent, making this a fascinating trip through identification history. -- J. A. Brown * Choice *Cole's comprehensive...book investigates the tangled intersections of scientific identification and law enforcement...[with] rigorous detail and attention to historical ambiguities...This well-wrought history will be admired by scholars and serious lay readers. * Publishers Weekly *Cole's Suspect Identities is far more than a masterly and detailed chronicle of the journey from the anonymous mobile stranger in the seventeenth century to today's DNA-fingerprinted sex offender whose moves are tracked via the Internet. It is also an astute analysis of the social, political, and economic forces that explain why the journey took certain paths. This book sets the high benchmark for scholarship in this area. -- Troy Duster, New York UniversitySuspect Identities is a fascinating account of an important subject. In his history of identification techniques from fingerprints to DNA, Simon Cole tells the story of our recurring attempts to forge reliable links between bodies, persons, and crimes. As Cole shows in these pages, the aim of these techniques, from Martin Guerre to O. J. Simpson, is not just to link persons with criminal acts. It is to link persons to themselves, to establish their identities with the certainty of science, and to use these identifiers for bureaucratic and diagnostic purposes. And therein lies their danger, as well as their usefulness, as critics of 'DNA fingerprinting' are beginning to discover. Written with intelligence, wit, and insight, this book will stand as the definitive account for a long time to come. -- David Garland, author of The Culture of Control: Crime and Social Order in Late ModernitySuspect Identities shows that a fascinating journey through the history of science can illuminate current controversies. This well-written book teaches us as much about the problems facing forensic scientists today as it does the history of fingerprinting. -- Barry Scheck, Co-Director, The Innocence ProjectTable of ContentsPrologue: Jekylls and Hydes 1. Impostors and Incorrigible Rogues 2. Measuring the Criminal Body 3. Native Prints 4. Degenerate Fingerprints 5. Fingerprinting Foreigners 6. From Anthropometry to Dactyloscopy 7. Bloody Fingerprints and Brazen Experts 8. Dazzling Demonstrations and Easy Assumptions 9. Identification at a Distance 10. Digital Digits 11. Fraud, Fabrication, and False Positives 12. The Genetic Age Epilogue: Bodily Identities Notes Credits Acknowledgments Index

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Book SynopsisAcclaimed author Matt Ridley's thrilling follow-up to his bestseller 'Genome'. Armed with the extraordinary new discoveries about our genes, Ridley turns his attention to the nature versus nurture debate to bring the first popular account of the roots of human behaviour.Trade Review‘“Nature via Nurture” sets the modern terms for an ancient debate, and at the same time delivers a superb tutorial on contemporary genetics; the feedback loop that embraces genes and environment is generally not well understood. And yet this plasticity, this elegant mutuality, seems crucial if our new understanding of human nature is to inform public policy. These times need a book like this.’ Ian McEwan ‘Lucidly explains the most recent discoveries on what makes us what we are, and how we should think about these discoveries as we ponder who we want to be…A treat, written with insight, wisdom, and style.’ Steven Pinker, author of ‘The Blank Slate’ ‘Bracingly intelligent, lucid, balanced – witty, too. “Nature via Nurture” is a scrupulous and charming look at our modern understanding of genes and experience.’ Oliver Sacks ‘A real page-turner. What a superb writer he is, and he seems to get better and better.’ Richard Dawkins, author of ‘The Selfish Gene’

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Book SynopsisRecognizing the significant advances made in the field of animal genetics in the ten years since the first edition of Genetics of the Dog, this new edition of the successful 2001 book provides a comprehensive update on the subject, along with new material on topics of current and growing interest. Existing chapters on essential topics such as immunogenetics, genetics of diseases, developmental genetics and the genetics of behaviour have been fully updated, while new authors report on the latest advances in areas such as genetic diversity of dog breeds, canine genomics, olfactory genetics and cancer genetics.Table of Contents1: Canid phylogeny and origin of the domestic dog. 2: Experimental studies of early canid domestication 3: Genetic diversity and phylogenetic relationships of dog breeds. 4: Molecular genetics of coat colour, texture and length 5: Mendelian traits in the dog 6: Immunogenetics 7: Genetic aspects of orthopaedic disorders in the dog 8: Genetics of cancer in dogs 9: Genetics of neurological disease in the dog 10: Genetics of eye disorders in the dog 11: Cytogenetics and chromosome maps 12: Canine genomics 13: Genetics of canine behavioural disorders 14: Biology of reproduction and modern reproductive technology 15: Developmental genetics 16: Genetics of morphological traits 17: Olfactory genetics 18: Pedigree analysis, genotype testing and genetic counselling 19: Genetics of quantitative traits and improvement of the dog breeds 20: Complex traits. 21: Canine model in medical genetics 22: Genetic aspects of performance in working dogs 23: Genetic nomenclature

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Book Synopsis*Contemporary, Broad Coverage covers every aspect of the rapidly changing field of proteomics from *Coherent and Student friendly based on the highly successful course developed by the author at Manchester University.Table of ContentsPreface ix Acknowledgements xi 1 Introduction 1 1.1 What Are the Tasks in Proteomics? 1 1.2 Challenges in Proteomics 5 1.3 Proteomics in Relation to Other -omics and System Biology 10 1.4 Some General Applications of Proteomics 12 1.5 Structure of the Book 18 References 18 2 Separation and Detection Technologies 21 2.1 Introduction to Experimental Strategies in Proteomics 21 2.2 Gel-Based Separation 31 2.3 Visualization and Analysis of Proteins/Peptides in Gels 40 2.4 Gel-Free Separation Technologies 54 2.5 Visualization of Proteins/Peptides from Hyphenated Methods 74 2.6 Chips in Proteomic Applications 81 References 81 3 Analysis of Peptides/Proteins by Mass Spectrometry 83 3.1 Basic Principles of Mass Spectrometry for Proteomics 83 3.2 Ionization Methods for Small Amounts of Biomolecules 101 3.3 Mass Analyzers and Mass Spectrometers 116 3.4 Concluding Remarks on Mass Analyzers for Proteomics 170 References 170 4 Analysis and Interpretation of Mass Spectrometric and Proteomic Data 173 4.1 Introduction 173 4.2 Analysis of MS Data 174 4.3 Analysis of MS/MS Data 192 4.4 Quantification of LC MS and MS/MS Data from Complex Samples 209 4.5 Bioinformatic Approaches for Mass Spectrometric Proteome Data Analysis 213 References 218 5 Strategies in Proteomics 221 5.1 Imaging Mass Spectrometry 221 5.2 Qualitative Proteomics 223 5.3 Differential and Quantitative Proteomics 234 5.4 Analysis of Posttranslational Modifications 257 5.5 Interaction Proteomics 261 5.6 Proteomics as Part of Integrated Approaches 266 References 271 Index 275

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Book SynopsisThe Glencoe Biology Student Edition is print book. It is written in a student friendly narrative that will equip students to â Meet science standards Performance Expectations (PEâs).â Integrate Science and Engineering Practices into your science classroomâ Supply the Disciplinary Core Ideas (DCIâs)â Correlate your lessons to NGSSâ Encounter STEM projects

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Book SynopsisA Copernican revolution for the life sciences.—Medical TribuneUnlock the mysteries of biology, anthropology, and ancient civilizations in this thought-provoking read where science and spirituality intersect. Through Jeremy Narby′s travels and research in the Amazon, he discovered that shamans were able to use hallucinogens to tap into knowledge and insights that rival our discoveries using modern scientific methods, particularly with regards to DNA and molecular biology. Drawing on visionary experiences, indigenous knowledge, and pharmacology, Narby challenges conventional understanding, unraveling the connections between consciousness, serpent symbolism, and the origins of life itself. This enlightening book blends science, anthropology, and mysticism into a captivating narrative that will expand your mind.

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Book SynopsisElaborates on author's pioneering work on developmental systems by spelling out that work's implications for the fields of evolutionary theory, developmental and social psychology, feminism, and epistemology.Trade Review“Oyama writes elegantly and from a deep intellectual base. This alternative view to the dominant genetic determinism will be of interest to all who seek a more complex view of human nature. It is an excellent book, beautifully composed.”—Katherine Nelson, City University of New York“Susan Oyama's Ontogeny of Information provided a navigational chart for researchers seeking to avoid the shoals of the nature-nurture dichotomy. Here, in Evolution's Eye, she good-humoredly unmasks the rhetorical stratagems of reflexive genecentrism, while continuing to strengthen the case for the integrative, multifocal approach of developmental systems theory.”—Helen E. Longino, University of Minnesota“To think of nature and nurture as two distinct categories is not only wrong, Susan Oyama convincingly argues, but doing so hobbles our attempts to understand the nature of development and evolution at every level. Hers is a voice that needs to be heard.”—Evelyn Fox Keller, Massachusetts Institute of TechnologyTable of ContentsAcknowledgments Introduction Part 1: Looking at Development and EvolutionTransmission and Construction: Levels and the Problem of Heredity What Does the Phenocopy Copy? Originals and Fakes in Biology Ontogeny and the Central Dogma: Do We Need the Concept of GeneticProgramming in Order to Have an Evolutionary Perspective? Stasis, Development, and Heredity: Models of Stability and Change The Accidental Chordate: Contingency in Developmental Systems Part 2: Looking at Ourselves Essentialism, Women, and War: Protesting Too Much, Protesting TooLittle The Conceptualization of Nature: Nature as Design Bodies and Minds: Dualism in Evolutionary Theory How Shall I Name Thee? The Construction of Natural Selves Evolutionary and Developmental Formation: Politics of the Boundary Notes References Index

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Book SynopsisA NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow

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Book SynopsisThe DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's.Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease.In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth.Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.

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Book SynopsisSince the time of domestication more than 10,000 years ago, cattle have played an increasingly crucial role in the development of human civilizations. Progress has been quite remarkable since the turn of the century; the sequencing of the bovine genome in 2009 launched new avenues for furthering our understanding of theoretical and practical aspects of cattle genetics. Covering a vast array of questions, this book reviews major topics from molecular and developmental genetics, disease resistance and immunogenetics to genetic improvement of dairy and beef breeds, addressing all current problems in the field. This second edition includes a new team of authors and completely new chapters on the genetics of fat production, nutrition, feed intake and efficiency, growth and body composition. Fully updated throughout, it provides a valuable resource on cattle genetics for researchers, breeders, veterinarians and postgraduate students.Table of Contentsa: Preface Chapter 1: Systematics and phylogeny of cattle Chapter 2: Genetic aspects of domestication Chapter 3: Breeds of cattle Chapter 4: Molecular genetics of colour variation Chapter 5: Genetics of morphological traits and inherited disorders Chapter 6: Cytogenetics and chromosome maps Chapter 7: Bovine genomics Chapter 8: Bovine immunogenetics Chapter 9: Genetics of disease resistance Chapter 10: Molecular biology and genetics of bovine spongiform encephalopathy Chapter 11: Genetics of behaviour in cattle Chapter 12: Genetics of reproduction in cattle Chapter 13: Modern reproductive technologies and breed improvement Chapter 14: Developmental genetics Chapter 15: Genetic improvement of dairy cattle Chapter 16: Molecular genetics of milk protein production Chapter 17: Genetics fatty acids composition in bovine milk and beef Chapter 18: Genetic improvement in beef cattle Chapter 19: Genomic prediction and genome-wide association studies in beef and dairy cattle Chapter 20: Genetics of feed intake and efficiency. Chapter 21: Genetics of growth and body composition Chapter 22: Genetics of meat quality Chapter 23: Genetic aspects of cattle adaptation in the tropics Chapter 24: Standard genetic nomenclature b: Index

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Book SynopsisForward -- A Brave New World., Chapter 1.  From Genes to Genomes:  What's It All About?  ([Author's Note: Introduction; include short genetics history]., Chapter 2.  My Family's Medical History (and why it's important for me to know)., Chapter 3.  A Savior Sibling [Author's Note:  Preimplantation genetic diagnosis/Selection]., Chapter 4. Too Few, Too Many [Author's Note: Aneuploidy/Copy Number Variation]., Chapter 5. You've Probably Already Had a Genetic Test (But no one told you):   Newborn Screening., Chapter 6. Sweet Blood (Genetics and Diabetes)., Chapter 7.  Will this Drug Work for You? [Author's Note:  Pharmacogenetics/Creating a Drug Just for You]., Chapter 8.  No Two Cancers Are the Same [Author's Note:  Microarrays and Disease sub-classification]., Chapter 9.  Can We Fix our Faulty Genes? [Author's Note: Gene Therapy/Genome Editing-CRISPR]., Chapter 1Table of ContentsForward -- A Brave New World [Part I -- Introduction] Chapter 1. From Genes to Genomes: What’s It All About? ([Author’s Note: Introduction; include short genetics history] [Part II – Medical Applications] Chapter 2. My Family’s Medical History (and why it’s important for me to know) Chapter 3. A Savior Sibling [Author’s Note: Preimplantation genetic diagnosis/Selection] Chapter 4. Too Few, Too Many [Author’s Note: Aneuploidy/Copy Number Variation] Chapter 5. You’ve Probably Already Had a Genetic Test (But no one told you): Newborn Screening Chapter 6. Sweet Blood (Genetics and Diabetes) Chapter 7. Will this Drug Work for You? [Author’s Note: Pharmacogenetics/Creating a Drug Just for You] Chapter 8. No Two Cancers Are the Same [Author’s Note: Microarrays and Disease sub-classification] Chapter 9. Can We Fix our Faulty Genes? [Author’s Note: Gene Therapy/Genome Editing-CRISPR] Chapter 10. Hunting the Invisible Bugs through DNA (Author’s Note: Infectious disease/MRSA story) Chapter 11. Can Genes Explain Behavior? (Note: Behavioral Genetics/Gene x Environment) [Part III – Non-medical Applications] Chapter 12. The Not So Golden Age of Golden Rice {alternative title: Tastier (and Healthier) Foods through Genetic Technology} Chapter 13. Cleaning up the Environment: New Ways to Detect Land Mines and Digest Oil Chapter 14. Genetics and the Crime Scene: Just like TV? Chapter 15. Are We Related to Cavemen? [Alternative Title: Ancient Ancestors] [Author’s Note: Neanderthal/woolly mammoth/Population history/Redefining Race] Chapter 16. Creating New Life [Alternative Title: Bringing back Extinct Species] Chapter 17. Genetic Testing Without A Physician – A Brave New World [Author’s Note: Direct to Consumer Marketing] [move this to Part II?]

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Book SynopsisCompletely updated and revised, the third edition of this essential textbook describes the basic genetics of the horse including coat colour, parentage, medical and population genetics, cytogenetics, performance, breeding systems and genetic conservation, as well as the many recent advances in genomics. New for the third edition: - More information on genomics and biology have been included - There are two additional chapters on genetics with respect to infectious diseases and reproduction - Expanded sections on quantitative genetics and genomic selection provide comprehensive coverage - Many new figures further illustrate key points in the text - Redesigned in colour throughout and keeping the popular features of previous editions This authoritative text remains one of the key sources of information for basic genetic principles and their specific applications to the horse, and is essential for students of equine studies, animal breeding and veterinary science, as well as horse breeders and owners.Table of Contents1: Nature of Breeds 2: Evolution and Domestication 3: Equus 4: Fundamentals of Genetics 5: The Language of Genetics 6: Genomics 7: Black, Bay, and Chestnut (Extension and Agouti) 8: Color Diluting Genes 9: Tobiano, White, Sabino and Roan (KIT) 10: Frame Overo and Splashed White 11: Leopard Complex 12: Gray, Brindle, Curly and Tiger Eye 13: Putting it All Together: Color By Design 14: Parentage Testing 15: Blood Groups and Neonatal Isoerythrolysis 16: Medical Genetics 17: Cytogenetics 18: Major Genes, Quantitative Trait Loci and Marker Assisted Selection 19: Complex Traits 20: Pedigrees and Breeding Schemes 21: Microbiome and Mitochondria 22: Where Do We Go From Here?

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Book SynopsisGenomics has transformed the biological sciences. From epidemiology and medicine to evolution and forensics, the ability to determine an organism''s complete genetic makeup has changed the way science is done and the questions that can be asked of it. Its most celebrated achievement was the Human Genome Project, a technologically challenging endeavor that took thousands of scientists around the world 13 years and over 3 billion US dollars to complete. In this Very Short Introduction John Archibald explores the science of genomics and its rapidly expanding toolbox. Sequencing a human genome now takes only a few days and costs as little as $1,000. The genomes of simple bacteria and viruses can be sequenced in a matter of hours on a device that fits in the palm of your hand. The resulting sequences can be used to better understand our biology in health and disease and to ''personalize'' medicine. Archibald shows how the field of genomics is on the cusp of another quantum leap; the implications for science and society are profound.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.Trade ReviewGenomics does an amazingly good job of covering the gist and gestalt of arguably the most wide-ranging and fastest developing of the biological sciences. * CHOICE Reviews *Table of Contents1: What is genomics? 2: How to read the book of life 3: Making sense of genes and genomes 4: The human genome in biology and medicine 5: Evolutionary genomics 6: Genomics and the microbial world 7: The future of genomics Further Reading Index

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Book SynopsisThis book presents up-to-date information on the origins of the Ashkenazic Jewish people from central and eastern Europe based on genetic research on modern and pre-modern populations. It focuses on the 129 maternal haplogroups that the author confirmed that Ashkenazim have acquired from distinct female ancestors who were indigenous to diverse lands that include Israel, Italy, Poland, Germany, North Africa, and China, revealing both their Israelite inheritance and the lasting legacy of conversions to Judaism. Genetic connections between Ashkenazic Jews and other Jewish populations, including Turkish Jews, Moroccan Jews, Tunisian Jews, Iranian Jews, and Cochin Jews, are indicated wherever they are known.Table of ContentsSummaryAcknowledgments1. An Introduction to Ashkenazic History and Genetics2. Encyclopedia of Ashkenazic Maternal Lineages3. Non-Ashkenazic Haplogroups in Populations Related to Ashkenazim4. ConclusionNotesBibliographyIndexAbout the Author

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Book SynopsisPhilosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope, and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as causation, explanation, modeling, and scientific inference. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: basic research, tranTrade ReviewPhilosophy of Molecular Medicine offers 12 insightful chapters of philosophical and historical reflections on foundational issues in molecular medicine. This edited volume offers a rich introduction to and discussion of important philosophical issues that arise at the interface of basic science, clinical research, and clinical practice.-Sara Green, SpringerTable of ContentsIntroduction Giovanni Boniolo and Marco J. NathanPart 1: Nature, Origins, and ScopeChap. 1: Molecular medicine: the clinical method enters the lab. What tumor heterogeneity and primary tumor culture teach us Giovanni BonioloChap. 2: Personalized Medicine: Historical Roots of a Medical Model Mariacarla Gadebusch Bondio and Francesco SpöringChap. 3: From the concept of genetic disease to the geneticization of diseases: analyzing and solving the paradox of contemporary medical genetics Marie Darrason Part 2: Explanation Chap. 4: Molecular complexity: Why has psychiatry not been revolutionized by genomics (yet)? Maël LemoineChap. 5: How cancer spreads: reconceptualizing a disease Katherine E. Liu, Alan C. Love, and Michael TravisanoChap. 6: Evolutionary Perspectives on Molecular Medicine: Cancer from an Evolutionary Perspective Anya PlutynskiPart 3: Representation and Modeling Chap. 7: Towards a Notion of Intervention in Big-Data Biology and Molecular Medicine Federico Boem and Emanuele RattiChap. 8: Pathways to the clinic: cancer stem cells and challenges for translational research Melinda Bonnie FaganChap. 9: Counterfactual Reasoning in Molecular Medicine Marco J. NathanPart 4: Inference Chap. 10: Forms of Extrapolation in Molecular Medicine Pierre-Luc Germain and Tudor BaetuChap. 11: Testing Oncological Treatments in the Era of Personalized Medicine David TeiraChap. 12: Opportunities and challenges of molecular epidemiology Federica Russo and Paolo Vineis

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Book SynopsisPlant diversity sustains all animal life, and the genetic diversity within plants underpins global food security. This text provides a practical and theoretical introduction to the strategies and actions to adopt for conserving plant genetic variation, as well as explaining how humans can exploit this diversity for sustainable development. Notably readable, it initially offers current knowledge on the characterization and evaluation of plant genetic resources. The authors then discuss strategies from in situ and ex situ conservation to crop breeding, exploring how these can be used to improve food security in the face of increasing agrobiodiversity loss, human population growth and climate change. Each chapter draws on examples from the literature or the authors'' research and includes further reading references. Containing other useful features such as a glossary, it is invaluable for professionals and undergraduate and graduate students in plant sciences, ecology, conservation, genetTrade Review'This work in fact builds on their contributions and will broaden the scope of any student's perspective.' T. Johnson, ChoiceTable of ContentsForeword; Preface; 1. Introduction; 2. Establishing the social, political and ethical context; 3. Plant taxonomy; 4. Plant population genetics; 5. Genetic diversity measurement; 6. Planning plant conservation; 7. Conservation strategies and techniques; 8. In situ conservation; 9. On-farm conservation; 10. Community-based conservation; 11. Germplasm collecting; 12. Seed gene bank conservation; 13. Whole plant, plantlet and DNA conservation; 14. Plant uses; 15. Germplasm evaluation; 16. Plant breeding; 17. Participatory plant breeding; 18. Conservation data management; Glossary; Acronyms and Abbreviations; References; Index.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisNow in full-color, the Second Edition of Human Evolutionary Genetics has been completely revised to cover the rapid advances in the field since publication of the highly regarded First Edition. Written for upper-level undergraduate and graduate students, it is the only textbook to integrate genetic, archaeological, and linguistic perspectives on human evolution, and to offer a genomic perspective, reflecting the shift from studies of specific regions of the genome towards comprehensive genomewide analyses of human genetic diversity. Human Evolutionary Genetics is suitable for courses in Genetics, Evolution, and Anthropology. Those readers with a background in anthropology will find that the streamlined genetic analysis material contained in the Second Edition is more accessible. The new edition also integrates new technologies (including next-generation sequencing and genome-wide SNP typing) and new data analysis methods, including recent data on ancient genTrade Review"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." - Human Genomics"This is an absolutely superb book! I have been recommending it enthusiastically to professional colleagues, graduate students, and even the occasional highly motivated undergraduate student, and the response has been overwhelmingly positive. Not only is the book unique in terms of topical coverage, but it is also extremely well executed. In fact, it is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." - American Journal of Human Genetics"I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." - Human Genetics"In all honesty, there are few comparable textbooks on this subject, and this edition of Human Evolutionary Genetics really raises the bar. I wholeheartedly recommend this volume, and anticipate building a course around it in my own teaching." - The Quarterly Review of Biology"This is a very valuable, stimulating and challenging book for students, who will benefit from having had a previous grounding in basic biology, chemistry and statistics. For teachers this will also be valuable as a comprehensive review for courses in several aspects of human evolutionary genetics and as a teach‌ing aid."- Journal of Biological Education"My thanks to the authors for updating an already outstanding book; you have outdone yourselves! Buy this book." - American Journal of Human Biology"Human Evolutionary Genetics is a highly recommended textbook that helps readers understand differences in the human genome and how evolution has affected development of the genome and acquired diversity....This book is very well laid out for those who want to introduce themselves to the concepts of evolution and genetics and is a good read for advanced undergraduates and graduates, as well as geneticists, human biologists, anthropologists, and others." - Yale Journal of Biology and Medicine"I strongly recommend this book to anyone with an interest in human evolutionary genetics or anthropological genetics. It would be an ideal choice for advanced undergraduates and graduate courses on this topic, and would also be a key reference for those active in such research." - Human Genomics"This is an absolutely superb book! I have been recommending it enthusiastically to professional colleagues, graduate students, and even the occasional highly motivated undergraduate student, and the response has been overwhelmingly positive. Not only is the book unique in terms of topical coverage, but it is also extremely well executed. In fact, it is one of the best textbooks on any subject I have ever read. It belongs on the shelves of everyone interested in the genetic aspects of human evolution. There is also much of value in it for paleoanthropologists, historical linguistics, archaeologists, and human biologists (biological anthropologists), as well as for geneticists with various complementary specialties and interests." - American Journal of Human Genetics"I strongly recommend Human Evolutionary Genetics as an undergraduate textbook. At the same time, I recommend this book to any readers with an interest in human evolution or human genetics." - Human Genetics"In all honesty, there are few comparable textbooks on this subject, and this edition of Human Evolutionary Genetics really raises the bar. I wholeheartedly recommend this volume, and anticipate building a course around it in my own teaching." - The Quarterly Review of Biology"This is a very valuable, stimulating and challenging book for students, who will benefit from having had a previous grounding in basic biology, chemistry and statistics. For teachers this will also be valuable as a comprehensive review for courses in several aspects of human evolutionary genetics and as a teach‌ing aid."- Journal of Biological Education"My thanks to the authors for updating an already outstanding book; you have outdone yourselves! Buy this book." - American Journal of Human Biology"Human Evolutionary Genetics is a highly recommended textbook that helps readers understand differences in the human genome and how evolution has affected development of the genome and acquired diversity....This book is very well laid out for those who want to introduce themselves to the concepts of evolution and genetics and is a good read for advanced undergraduates and graduates, as well as geneticists, human biologists, anthropologists, and others." - Yale Journal of Biology and MedicineTable of Contents1. An Introduction to Human Evolutionary GeneticsSection I: How Do We Study Genetic Variation? 2. Organization and Inheritance of the Human Genome 3. Human Genome Variation 4. Finding and Assaying Genome DiversitySection II: How Do We Interpret Genetic Variation? 5. Processes Shaping Diversity 6. Making Inferences from DiversitySection III: Where and When Did Humans Originate? 7. Humans as Apes 8. What Genetic Changes Have Made Us Human? 9. Origins of Modern HumansSection IV: How Did Humans Colonize the World? 10. The Distribution of Diversity 11. The Colonization of the Old World And Australia 12. Agricultural Expansions 13. Into New Found Lands 14. What Happens When Populations Meet?Section V: How Is An Evolutionary Perspective Helpful? 15. Understanding the Past, Present and Future of Phenotypic Variation16. Evolutionary Insights into Simple Genetic Diseases 17. Evolution and Complex Diseases 18. Identity and Identification

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Book SynopsisThe chromosome complement (karyotype) often differs between related mammalian species (including humans vs chimpanzees), such that evolutionary biologists muse whether chromosomal difference is a cause or a consequence of speciation. The common shrew is an excellent model to investigate this problem because of its many geographical races (potential species) differing chromosomally, and its several sibling species (recently speciated forms) that are also chromosomally different. This system is an exceptional opportunity to investigate the role of chromosomes in speciation and this volume reflects detailed research following these approaches. Highlights include the demonstration that chromosomal re-arrangements can be associated with complete loss of gene flow and thus speciation and that selection within species hybrid zones may lead to de-speciation rather than speciation. This book represents an extraordinarily detailed consideration of the role of chromosomes in speciation in one astTrade Review'I found Shrews, Chromosomes and Speciation fascinating, and an enjoyable read. This volume will be a welcome addition to the library of any evolutionary biologist or graduate student interested in how the interactions of chromosomes and the genome shape diversity.' Sally Potter, The Quarterly Review of BiologyTable of Contents1. Milestones in common shrew chromosomal research Jan Zima and Jeremy B. Searle; 2. Introducing the common shrew Nikolay A. Shchipanov, Jan Zima and Sara Churchfield; 3. Morphology and genetics of the common shrew: general features Alina Mishta and Jeremy B. Searle; 4. Phylogeography Susan Thaw, Thomas A. White, Anna A. Bannikova and Jeremy B. Searle; 5. Chromosomal differentiation in the common shrew and related species Nina S. Bulatova, Larisa S. Biltueva, Svetlana V. Pavlova, Natalia S. Zhdanova and Jan Zima; 6. Phylogenetic relationships of chromosomal races Thomas A. White, Jan M. Wojcik and Jeremy B. Searle; 7. Meiosis and fertility associated with chromosomal heterozygosity Pavel M. Borodin, Stanisław Fedyk, Włodzimierz Chętnicki, Anna A. Torgasheva, Svetlana V. Pavlova and Jeremy B. Searle; 8. Chromosomal hybrid zones Stanisław Fedyk, Svetlana V. Pavlova, Włodzimierz Chętnicki and Jeremy B. Searle; 9. Gene flow between chromosomal races and species Glenn Yannic, Patrick Basset, Agnès Horn and Jacques Hausser; 10. Geometric morphometric tests for phenotypic divergence between chromosomal races P. David Polly and Jan M. Wojcik; 11. Is it really the chromosomes? Patrick Basset, Glenn Yannic and Jacques Hausser; 12. Further divergence: the role of ecology and behaviour Boris I. Sheftel, Natalia V. Moraleva and Jacques Hausser; 13. Climate, diversification and refugia in the common shrew: evidence from the fossil record P. David Polly; 14. Shrews, chromosomes and speciation Jeremy B. Searle, Jan Zima and P. David Polly.

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Book SynopsisWhereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.Trade Review'Since the completion of the Human Genome Project we hold the 'book of life' in our hands, but for the most part, we do not understand how to interpret it. We lack an understanding of the grammar that it is written in. With this book the authors put together an impressive collection of chapters that provide insights into our current efforts to understand how genetic information is integrated, coordinated and ultimately assembled into biological systems. If you are interested in how to decipher the grammar of life this is a must read!' Frank Buchholz, Technische Universität Dresden, GermanyTable of ContentsList of contributors; 1. An introduction to systems genetics Florian Markowetz and Michael Boutros; 2. Computational paradigms for analyzing genetic interaction networks Carles Pons, Michael Costanzo, Charles Boone and Chad L. Myers; 3. Mapping genetic interactions across many phenotypes in metazoan cells Christina Laufer, Maximilian Billmann and Michael Boutros; 4. Genetic interactions and network reliability Edgar Delgado-Eckert and Niko Beerenwinkel; 5. Synthetic lethality and chemoresistance in cancer Kimberly Maxfield and Angelique Whitehurst; 6. Joining the dots: network analysis of gene perturbation data Xin Wang, Ke Yuan and Florian Markowetz; 7. High content screening in infectious diseases: new drugs against bugs André P. Mäurer, Peter R. Braun, Kate Holden-Dye and Thomas F. Meyer; 8. Inferring genetic architecture from systems genetics studies Xiaoyun Sun, Stephanie Mohr, Arunachalam Vinayagam, Pengyu Hong and Norbert Perrimon; 9. Bayesian inference for model selection: an application to aberrant signalling pathways in chronic myeloid leukaemia Lisa E. M. Hopcroft, Ben Calderhead, Paolo Gallipoli, Tessa L. Holyoake and Mark A. Girolami; 10. Dynamic network models of protein complexes Yongjin Park and Joel S. Bader; 11. Phenotype state spaces and strategies for exploring them Andreas Hadjiprocopis and Rune Linding; 12. Automated behavioural fingerprinting of C. elegans mutants André E. X. Brown and William R. Schafer; Index.

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Book SynopsisA comprehensive overview of Bayesian approaches to phylogenetics using Markov chain Monte Carlo (MCMC) methods, offering theoretical insight, pragmatic advice and tools to develop further models. This title is a one-stop reference to applying the latest phylogenetic models in BEAST 2, interpreting the analyses and extending these models further.Trade Review'Want to construct a phylogeny, add in calibrated time points or work out the past history of an epidemic? The open source package BEAST has established itself as the industry standard for all this and more. This definitive book, explaining what is under the hood, how the user can customize extensions and, most critically, a simple 'how to' users guide, is necessary reading for beginners and specialists alike.' Laurence D. Hurst, University of Bath'In concert with the dramatic improvements to DNA sequencing technology, Bayesian inference has revolutionized population genetics, phylogenetics, and divergence time estimation. A similar impact on epidemiology appears imminent via a suite of new Bayesian methods that incorporate host and pathogen DNA sequence data into established mathematical frameworks. This book is an accessible and thorough introduction to these Bayesian procedures. However, the book does far more than explain the theory. It also includes clear guides on how to use the BEAST 2 software for performing Bayesian analyses, and how to visualize the results. Because the software is designed to be extensible, the book instructs users to write their own code to supplement the diverse methods that are already implemented in BEAST 2. This book is timely and is written by two of the leaders of the field. I highly recommend it.' Jeff Thorne, North Carolina State UniversityTable of ContentsPreface; Acknowledgements; Part I. Theory: 1. Introduction; 2. Evolutionary trees; 3. Substitution and site models; 4. The molecular clock; 5. Structured trees and phylogeography; Part II. Practice: 6. Bayesian evolutionary analysis by sampling trees; 7. Setting up and running a phylogenetic analysis; 8. Estimating species trees from multilocus data; 9. Advanced analysis; 10. Posterior analysis and post-processing; 11. Exploring phylogenetic tree space; Part III. Programming: 12. Getting started with BEAST; 13. BEAST XML; 14. Coding and design patterns; 15. Putting it all together; Bibliography; List of authors; List of subjects.

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Book SynopsisSurveying the last sixty years of research, this book describes the physical properties of DNA in the context of its biological functioning. It is designed to enable both students and researchers of molecular biology, biochemistry and physics to better understand the biophysics of DNA, addressing key questions and facilitating further research. The chapters integrate theoretical and experimental approaches, emphasising throughout the importance of a quantitative knowledge of physical properties in building and analysing models of DNA functioning. For example, the book shows how the relationship between DNA mechanical properties and the sequence specificity of DNA-protein binding can be analyzed quantitatively by using our current knowledge of the physical and structural properties of DNA. Theoretical models and experimental methods in the field are critically considered to enable the reader to engage effectively with the current scientific literature on the physical properties of DNA.Table of ContentsPreface; 1. DNA structures; 2. Conformational transitions; 3. Equilibrium large-scale conformational properties of DNA; 4. DNA dynamics; 5. DNA-protein interaction; 6. Circular DNA; Index.

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Book SynopsisThe birthplace of modern humans, Africa, has the highest genetic diversity in the world, yet it remains vastly understudied. With biomedical research increasingly focused on human variation, studying the large population size and number of mutations in African genomes could unravel the complexity of phenotypic traits underlying the biology of our species and hold huge potential for scientific and medical advances. An initial chapter ''conceptualizes Africa'', providing relevant terminology. The first section covers genetic history and population structure. The next section looks at the genetic basis of common infectious diseases, such as leishmaniasis, malaria and tuberculosis, with a final part considering common non-communicable diseases, such as diabetes, hypertension, obesity, heart disease and cancer. Gene environment interaction under globalization and the burden of diseases of lifestyle are included. For researchers and graduate students in biological anthropology, genetic anthrTrade Review'The Genetics of African Populations in Health and Disease makes great strides to remedy this knowledge gap … this excellent volume is likely to be of interest to a broad range of geneticists and medical professionals.' Joseph Lachance, The Quarterly Review of Biology'The scope of the contributions varies widely, from studies of single diseases (e.g., breast cancer, visceral leishmaniasis) to broad surveys (e.g., orphan diseases of North Africa, evolution of disease resistance). The first and final essays review the state and development of genetics research and medicine in Africa. Common themes include public health infrastructure, transition from agrarian to urban lifestyles, pharmacogenomics, genetic diversity, and the dearth of research on African populations.' R. M. Denome, ChoiceTable of Contents1. Reflections on conceptualizing Africa for biological studies with a historical component: a small essay Shomarka Omar Y. Keita; 2. History and genetics in Africa: multidisciplinary efforts Shomarka Omar Y. Keita and Muntaser E. Ibrahim; 3. Disease, selection, and evolution in the African landscape Muntaser Ibrahim and Endashaw Bekele; 4. Genetic susceptibility to visceral leishmaniasis Hiba S. Mohamed, Muntaser E. Ibrahim and Jenefer M. Blackwell; 5. Genetics of infection in Sub-Saharan Africa: what can the study of Mendelian immunodeficiency disorders contribute? Melanie Newport; 6. Pharmacogenomics and infectious diseases in Africa: an evolutionary perspective Jennifer L. Baker, Daniel Shriner, Amy R. Bentley and Charles N. Rotimi; 7. A glimpse into pharmacogenomics in Africa Collet Dandara and Alice Matimba; 8. Genomics of cardiometabolic disorders in Sub-Saharan Africa Sally N. Adebamowo, Fasil Tekola-Ayele, Adebowale A. Adeyemo and Charles N. Rotimi; 9. Breast cancer in African populations Konduru S. Sastry and Lotfi Chouchane; 10. Socio-biological transition and cancer: prospects for Africa Sulma Mahmoud, Khalid O. Alfarouk, Ahmed M. Elhassan, Kamal Hamad and Muntaser E. Ibrahim; 11. The genetic epidemiology of orphan diseases in North Africa Lilia Romdhane, Olfa Messaoud, Rym Kefi, Afaf Tiar, Ahlem Amouri, Mourad Mokni, Neji Tebib, Mohamed Zghal, Abdelhamid Barakat, Ahmed Houmeida, Mariem Bozguiya, Mohamed Othman, Ghada El Qameh and Sonia Abdelhak; 12. Birth defects and genetic disease in Sub-Saharan Africa Ambroise Wonkam; 13. Neurogenetic disorders in Africa: hereditary spastic paraplegia: a case study Liena E. O. Elsayed, Ammar E. M. Ahmed and Giovanni Stevanin.

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Book SynopsisComputational thinking is increasingly gaining importance in modern biology, due to the unprecedented scale at which data is nowadays produced. Bridging the cultural gap between the biological and computational sciences, this book serves as an accessible introduction to computational concepts for students in the life sciences. It focuses on teaching algorithmic and logical thinking, rather than just the use of existing bioinformatics tools or programming. Topics are presented from a biological point of view, to demonstrate how computational approaches can be used to solve problems in biology such as biological image processing, regulatory networks, and sequence analysis. The book contains a range of pedagogical features to aid understanding, including real-world examples, in-text exercises, end-of-chapter problems, colour-coded Python code, and ''code explained'' boxes. User-friendly throughout, Computational Thinking for Life Scientists promotes the thinking skills and self-efficacy rTrade Review'An excellent and very gentle introduction to bioinformatics for biologists. In contrast to books that focus on algorithms and ignore programming or focus on programming without explaining algorithms, this book is a perfect blend of both algorithms and programming!' Pavel Pevzner, Ronald R. Taylor Chair and Distinguished Professor of Computer Science, University of California at San Diego'The ability to extract quantitative information from data is an essential skill for the modern biologist. In order to maximize the benefit of programming, use of existing computational tools and effective collaboration with computational scientists, biologists must be able to 'think computationally' by gaining a more algorithmic and logical thinking. In their book, Benny Chor and Amir Rubinstein introduce fundamental computational concepts to life sciences students. Each chapter covers a distinct computational idea motivated by a concrete biological challenge. Questions embedded throughout each chapter and code examples provide hands-on practice. Similarly to the way in which chemistry is perceived as being essential to the biology curriculum, computational thinking should also be considered a part of the modern biologist's basic training. This excellent book is essential reading for undergraduate life sciences students.' Assaf Zaritsky, Ben-Gurion University of the Negev, IsraelTable of ContentsIntroduction; Part I. Programming in Python: 1. Crash introduction to python; 2. Efficiency matters – gentle intro to complexity; Part II. Sequences: 3. Sets dictionaries and hashing; 4. Regular expressions and biological patterns; Part III. Networks: 5. Basic notions in graph theory; 6. Shortest paths and breadth first search; 7. Simulation of regulatory networks; Part IV. Images: 8. Digital images representation; 9. Image processing; Part V. Limitations of Computing: 10. Mission impossible; 11. Mission infeasible; Index.

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Book SynopsisThe increased and widespread availability of large network data resources in recent years has resulted in a growing need for effective methods for their analysis. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straightforward task because of the size of the data sets and the computer power required for the analysis. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces biological concepts and biotechnologies producing the data, graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this text provides an ideal introduction to and insight into the interdisciplinary field of network daTable of Contents1. From genetic data to medicine: from DNA samples to disease risk prediction in personalized genetic tests Luis Leal, Rok Košir and Nataša Pržulj; 2. Epigenetic data and disease Rodrigo González-Barrios, Marisol Salgado-Albarrán, Nicolás Alcaraz, Cristian Arriaga-Canon, Lissania Guerra-Calderas, Laura Contreras-Espinoza and Ernesto Soto-Reyes; 3. Introduction to graph and network theory Thomas Gaudelet and Nataša Pržulj; 4. Protein-protein interaction data, their quality, and major public databases Anne-Christin Hauschild, Chiara Pastrello, Max Kotlyar and Igor Jurisica; 5. Graphlets in network science and computational biology Khalique Newaz and Tijana Milenković; 6. Cluster analysis Richard Röttger; 7. Machine learning for data integration in cancer precision medicine: matrix factorization approaches Noël Malod-Dognin, Sam Windels and Nataša Pržulj; 8. Machine learning for biomarker discovery: significant pattern mining F. Llinares-Lopez and K. Borgwardt; 9. Network alignment Noël Malod-Dogning and Nataša Pržulj; 10. Network medicine Pisanu Buphamalai, Michael Caldera, Felix Müller and Jörg Menche; 11. Elucidating genotype-to-phenotype relationships via analyzes of human tissue interactomes Idan Hekselman, Moran Sharon, Omer Basha and Esti Yeger-Lotem; 12. Network neuroscience Alberto Cacciola, Alessandro Muscoloni and Carlo Vittorio Cannistraci; 13. Cytoscape: tool for analyzing and visualizing network data John H. Morris; 14. Analysis of the signatures of cancer stem cells in malignant tumours using protein interactomes and STRING database Krešimir Pavelić, Marko Klobučar, Dolores Kuzelj, Nataša Pržulj and Sandra Kraljević Pavelić.

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Book SynopsisWho was the scientific progenitor of eugenic thought? Amir Teicher challenges the preoccupation with Darwin''s eugenic legacy by uncovering the extent to which Gregor Mendel''s theory of heredity became crucial in the formation - and radicalization - of eugenic ideas. Through a compelling analysis of the entrenchment of genetic thinking in the social and political policies in Germany between 1900 and 1948, Teicher exposes how Mendelian heredity became saturated with cultural meaning, fed racial anxieties, reshaped the ideal of the purification of the German national body and ultimately defined eugenic programs. Drawing on scientific manuscripts and memoirs, bureaucratic correspondence, court records, school notebooks and Hitler''s table talk as well as popular plays and films, Social Mendelism presents a new paradigm for understanding links between genetics and racism, and between biological and social thought.Trade Review'Amir Teicher's wide-ranging and provocative history of Mendelism in the German-speaking world will bust the myth that it was Darwinian selectionism alone that provided scientific justifications for right-wing ideologies of racial purification.' Staffan Müller-Wille, University of Cambridge'Amir Teicher's lucid study demonstrates that, similar to the way in which Darwin's work gave rise to Social Darwinism, the research method based on Gregor Mendel's experiments became transformed into a general interpretive framework - which Teicher calls 'Social Mendelism' - that exerted a powerful influence on the German biosciences in the first half of the twentieth century.' Richard F. Wetzell, German Historical Institute Washington'Revelatory.' Gregory Radick, Times Literary Supplement'This ambitious and thoroughly researched book seeks to achieve nothing less than a major rethink of the intellectual background to Nazism.' Dan Stone, German Studies Review'Teicher's seminal study shows how Mendelism played an essential role in the rise, development and radicalization of German racial hygiene. What has long been known in relation to Darwinism, Teicher elaborates in a differentiated argument for Mendelism: he provided a reservoir of images, metaphors and arguments from which National Socialists drew in order to scientifically legitimize their racial and sterilization policies. Teicher's narrative does not follow a straight path; no 'from Mendel to Hitler'. Rather, he repeatedly emphasizes the contradictions, polyvalences, and contingencies that determined the political use of Mendelism. It is precisely in this way that Teicher's study sharpens our view of the ambivalent and historically changing entanglements between science and ideology. (in German)' Pascal German, RezensionsredakteurTable of ContentsIntroduction; 1. Mendel's laws and their application to humans, 1865–1913; 2. Mendelism maturing: from experimental to interpretative framework, 1913–1933; 3. Mendelism, purity and national renewal; 4. Annihilating defective genes: Mendelian consciousness and the sterilization campaign; 5. Mendelizing racial antisemitism; Epilogue: social Mendelism beyond the Nazis.

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Book SynopsisCovering a range of metaphors from a diverse field of sciences, from cell and molecular biology to evolution, ecology, and biomedicine, Understanding Metaphors in the Life Sciences explores the positive and negative implications of the widespread use of metaphors in the biological and life sciences. From genetic codes, programs, and blueprints, to cell factories, survival of the fittest, the tree of life, selfish genes, and ecological niches, to genome editing with CRISPR''s molecular scissors, metaphors are ubiquitous and vital components of the modern life sciences. But how exactly do metaphors help scientists to understand the objects they study? How can they mislead both scientists and laypeople alike? And what should we all understand about the implications of science''s reliance on metaphorical speech and thought for objective knowledge and adequate public policy informed by science? This book will literally help you to better understand the metaphorical dimensions of science.Trade Review'What a timely book this is! It is precisely because biology has made such striking advances in recent years that its stock of metaphors is due for a clinical check-up. Reynolds offers a reliable and perceptive diagnosis of the framing narratives of the life sciences, sympathetically examining their strengths and weaknesses. This book should be an essential accompaniment to any study course in the biological sciences.' Philip Ball, science writer and author of How to Grow a Human'In this beautifully written, highly accessible, and captivating work, Reynolds reveals the incredible extent to which scientific methods and descriptions in biology, the life sciences, and medicine are infused with metaphors. Interweaving the rich history and philosophy of the uses of these metaphors over time, their many implications for scientific reasoning, understanding, and the ethical and political dimensions of science itself are perceptively explored, with wonderful clarity and across an encyclopedic range of examples. Metaphors afford telling insight, opening doors to further inquiry and closing others. Is your genome software? Are enzymes molecular machines? Does nature select some traits over others, thereby constructing the tree of life? The fascinating world of metaphors in science comes to life on every page.' Anjan Chakravartty, University of Miami, USA'I read Lakoff and Johnson's book Metaphors We Live By in the 1980s, and it was eye opening. Andrew Reynolds' book, which should be called Metaphors Science Lives By, is equally eye opening. Metaphors shape the way we live in the world. In science, they shape the way we understand the world. This can have huge implications for our lives, for better or for worse. How does this process of understanding work, especially in the life sciences? This book deals with the essential role of metaphors in this process. Written in an admirably clear style, Reynolds makes us aware of the power of metaphor, but also its dangers and pitfalls. It is an essential read for everybody interested in understanding how science and science communication work with and through metaphors. Importantly, it also dispels some common misunderstandings about the role of metaphors in science.' Brigitte Nerlich, University of Nottingham, UK'Understanding Metaphors in the Life Sciences takes us from genes to cells, and up to the vast evolutionary tree of life, showing how science depends overwhelmingly on metaphor for understanding, for advance, for communication. A very important book.' Michael Ruse, Florida State University, USA'Philosophically illuminating and richly informative on genetics, evolution and ecology, it should be obligatory reading for students in both the humanities and the sciences.' Jane O'Grady, Literary Review'Clear and concise, the book has an immense didactic value and will serve as a precious teaching aid in history and philosophy classes. However, despite being intended as an entry-level text, the book is more than a synthetic introduction to the subject. Beyond the analysis and evaluation of some of the most iconic metaphors in the life sciences, Reynolds provides a unique perspective on their function and use.' Bartlomiej Swiatczak, Metascience'Philosophically illuminating and richly informative on genetics, evolution and ecology, it should be obligatory reading for students in both the humanities and the sciences.' Jane O'Grady, Literary ReviewTable of Contents1. Metaphors and science; 2. Background metaphors: agents, machines, and information; 3. Genes and genomes: agents, codes, programs, blueprints, and books; 4. Proteins: machines, messengers, and team players; 5. Cells: factories, computers, and social organisms; 6. Evolution: natural selection, the tree of life, and selfish genes; 7. Ecology: the balance of nature, niches, ecosystem health, and gaia; 8. Biomedicine: genetic engineering, genome editing, and cell reprogramming.

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Book SynopsisUnlock the family secrets in your DNA! Discover the answers to your family history mysteries using the most cutting edge tool available. This plain-English guide (newly updated and expanded to include th latest DNA developments) will teach you what DNA tests are available; the pros and cons of the major testing companies; and how to choose the right test to answer your specific genealogy questions.  And once you''ve taken a DNA test, this guide will help you use your often-overwhelming results, with tips for understanding ethnicity estimates, navigating suggested cousin matches, and using third-party tools like GEDmatch to further analyze your data. The book features: ·         Colorful diagrams and expert definitions that explain key DNA terms and concepts such as haplogroups and DNA inheritance patterns ·         Detailed guides to each of the ma

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Book SynopsisThis book opens with a discussion on the clinical applications of comet assay. Comet assay is rapid, simple method which able to assess DNA damage in different samples like blood, cells and tissues. Following this, the authors examine comet assay usage in occupational toxicology studies. Isolated lymphocytes were the most used cell line in these studies, but exfoliated cells such as nasal and buccal cell, liver, kidney and sperm cells may be used. Comet assay may also be used to detect nanoparticles-associated DNA damage. As such, this compilation assesses potential limitations due to the interaction of the nanoparticles with the method. Next, to shed light on the mechanisms of the DNA track formation, the authors apply an original approach based on the kinetic measurements in the comet assay, arguing that in neutral conditions at low levels of DNA damages, the comet tail is formed by extended DNA loops. New applications of the comet assay are described for the detection of aberrant DNA methylation, which is a promising marker in cancer diagnosis and follow-up. The authors go on to describe and analyse the results of in vitro treatment of lymphocytes with insecticide using comet assay under alkaline and neutral conditions, testing the commercial product Calypso® 480SC and its active agent thiacloprid at concentrations of 30; 60; 120; 240 and 480 �g.ml-1. In one study, Helianthus annuus (sunflower) seedlings were irrigated with Hoagland solution containing different concentrations of AlCl3. Morphological parameters such as germination rate and stoma number are evaluated. Additionally, the genotoxic effects of endosulfan pesticide at different times and in different concentrations in wheat leaf samples are analyzed in two-week old wheat seedlings in an effort to demonstrate that endosulfan is a genotoxic agent causing DNA breaks in wheat. In the closing chapter, the correlation between the comet assay parameters, cell viability, and hydroquinone concentration is explored. The relationship between comet assay and remaining hydroquinone after fungal treatment is also investigated in order to evaluate its biodegradation efficiency.Table of ContentsPrefaceClinical Applications of Comet AssayComet Assay in Occupational Toxicology StudiesThe Comet Assay as a Tool to Detect the Genotoxic Potential of NanomaterialsKinetic Approach in Comet Assay: An Opportunity to Investigate DNA LoopsEvaluation of Global DNA Methylation Status of Single Cells by the Comet Assay: A Promising Approach in Cancer Diagnosis and Follow-UpComet Assay: A Suitable Method for in Vitro Genotoxicity Assessment Using Animal LymphocytesDetermination of Aluminum-Induced Oxidative and Genotoxic Effects in Sunflower LeavesDetermination of Genotoxic Effects of Organochlorine Pesticides in Wheat (Triticum aestivum L.) by Comet AssayInvestigation of Genotoxic Effects of Organophosphorus Pesticides in Barley (Hordeum vulgare L.)Genotoxicity of Hydroquinone and Fungal Detoxification: Correlation with Hydroquinone Concentration and Cell ViabilityIndex.

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Book SynopsisIn Chapter One, the authors discuss the gene silencing tool RNA interference, or RNAi, which functions at both transcriptional and post-transcriptional levels. In Chapter Two, the authors study the origins of genome engineering, including its adaptation from prokaryotic to eukaryotic systems and applications. In Chapter Three, the authors discuss the utilisation of different biotechnologies for insect pest management in plants, as well as give insight into recently developed approaches of genome editing for high through-put pest management. Closing the book with Chapter Four, the authors discuss how vital genetic resources, such as the ability to withstand scarcity of nutrients and water as well as to withstand pests and diseases, may be secured for future use in order to improve crops.

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Book SynopsisThis 8 volume encyclopedia set presents important research on genetics. Some of the topics discussed herein include the speciation of Arabian gazelles, tau alternative splicing in Alzheimer's disease, Cornelia de Lange syndrome and autosomal dominant polycystic kidney disease.Table of ContentsFor more information, please visit our website at:Print: https://www.novapublishers.com/catalog/product_info.php?products_id=65602E-Book: https://www.novapublishers.com/catalog/product_info.php?products_id=65603

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Book SynopsisA biomarker is a biochemical, cellular, physiological or behavioral variation that can be measured in tissue or body fluid samples or at the level of whole organisms that provides evidence of exposure to and/or effects of one or more chemical pollutants or radiations. Based on the facts related to the existence of contaminant stressors, an understanding of chemical modes of toxicity can be incorporated with diagnostic markers of aquatic animal physiology to help understand the health status of aquatic organisms in the field. New approaches in functional genomics and bioinformatics can help discriminate individual chemicals, or groups of chemicals among complex mixtures that may contribute to adverse biological effects. By using these recent methodologies, it could be useful to shed light on the molecular evolution of the biomarkers, and which role and functionality can be better understood based on exploring the relative evolution pathways in several aquatic organisms. PhD students and scientists with interests on physiology, ecotoxicology, biochemistry, molecular biology, molecular evolution and aquatic science disciplines will find this book very useful, based on the concepts and the relative biomarkers study cases, analyzed from the evolutionary point of view.Table of ContentsFor more information, please visit our website at:https://novapublishers.com/shop/molecular-evolution-of-aquatic-organisms-biomarkers/

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