Gastroenterology Books

Book SynopsisTests your ability to interpret a range of images seen in practice. This book features 200 cases that are suitable for reference and board review.Trade Review"This is a high-quality review of the range of conditions encountered in gastrointestinal radiology. It should prove useful for general radiologists in practice as a guide and a reference, and should also be useful for trainees as a teaching guide and for board exam preparation. It has been updated from the previous edition of 2008 to reflect changes in practice."- Bennett Greenspan, MD, MS (Medical College of Georgia) 5 star Doody Rating!Table of ContentsOpening Round Fair Game Challenge Index of Cases Index of Terms

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Book SynopsisTable of Contents1 Non-Neoplastic Disorders of the Esophagus 2 Tumors of the Esophagus 3 Non-Neoplastic Disorders of the Stomach 4 Epithelial Polyps and Neoplasms of the Stomach 5 Non-Neoplastic and Inflammatory Disorders of the Small Bowel 6 Neoplasms of the Small Intestine 7 Gastrointestinal Mesenchymal Tumors 8 Non-Neoplastic and Neoplastic Disorders of the Appendix 9 Infectious Diseases of the Gastrointestinal Tract 10 Non-Neoplastic Disorders of the Colon 11 Gastrointestinal Polyposis Syndromes 12 Epithelial Neoplasms of the Colorectum 13 Molecular Testing of Gastrointestinal Neoplasms 14 Pathology of the Anal Canal 15 Pathology of the Gallbladder and Extrahepatic Bile Ducts 16 Non-Neoplastic and Neoplastic Pathology of the Pancreas 17 Non-Neoplastic Disorders of the Liver 18 Liver Neoplasms 19 Gastrointestinal Lymphoma 20 Pathology of Liver, Small Bowel, and Pancreas Transplantation Index

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Book SynopsisTable of ContentsSECTION I ESOPHAGUS Anatomy of the Esophagus and the Foregut Congenital Anomalies of the Esophagus Deglutition Benign Disease of Esophagus Esophageal Diverticula Foreign Bodies in the Esophagus Caustic Injury of the Esophagus Esophageal Varicosities Esophageal Rupture and Perforation Eosinophilic Esophagitis GERD Sliding and Paraesophageal Hiatal Hernias Types 1, 2, and 3 Esophageal Motility Disorders Neoplastic Disease of the Esophagus SECTION II STOMACH AND DUODENUM Anatomy of the Stomach and Duodenum Gastric Secretion Factors Influencing Gastric Activity Role of the Stomach in Digestion Gastric Acid Secretion Tests: Hydrochloric Acid and Gastrin Effect of Drugs on Gastric Function Upper Gastrointestinal Endoscopy: Esophagogastroduodenoscopy Coated Tongue, Halitosis, and Thrush Aerophagia and Eructation Motility of the Stomach Gastroparesis and Gastric Motility Disorders Pyloric Obstruction and the Effects of Vomiting Nausea and Vomiting Hypertrophic Pyloric Stenosis Diverticula of the Stomach and Gastrointestinal Prolapse Diverticula of the Duodenum Dyspepsia, Functional Dyspepsia, and Nonulcer Dyspepsia Helicobacter pylori Infection Gastritis: General, Erosive and Acute Peptic Ulcer Disease Upper Gastrointestinal Bleeding Therapeutic Gastrointestinal Endoscopy Benign Tumors of the Stomach and GISTs Gastrintestinal Lymphoma and Mucosa-Associated Lymphoid Tissue Cancers of the Stomach Tumors of the Duodenum Principles of Gastric Surgery Postgastrectomy Complications: Partial Gastrectomy Effects of Total Gastrectomy SECTION III Abdominal wall Anatomy of the Abdominal Wall and Inguinal Region Peritoneum and Related Diseases Mesenteric Ischemia and other Vascular Lesions Alimentary Tract Obstruction and Intestinal Injuries Abdominal wall and abdominal cavity hernias Abdominal Cavity Access: Open Laparotomy, Laparoscopy, and Robotic access SECTION IV SMALL INTESTINE Anatomy of the Small Intestine Secretory, Digestive, and Absorptive Functions of the Small Intestine Gastrointestinal Hormones and Neurotransmitters Imaging of the Small Intestine Visceral Reflexes Congenital Abnormalities of the Small Intestine Meckel Diverticulum Diverticula of the Small Intestine Motility and Dysmotility of the Small Intestine Obstruction and Ileus of the Small Intestine Chronic Intestinal Pseudo-Obstruction Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Evaluation of the Small Bowel Lactose, Fructose, and Sucrose Intolerance Diarrhea Celiac Disease and Malabsorption Whipple Disease Small Intestinal Bacterial Overgrowth Short Bowel Syndrome Food Allergy Eosinophilic Gastroenteritis Intussusception of the Small Intestine Benign Tumors of the Small Intestine Malignant Tumors of the Small Intestine Carcinoid Syndrome and Neuroendocrine Tumors Ileostomy, Colostomy, and Gastroenteric Stromas SECTION V COLON, RECTUM, AND ANUS Anatomy of the Colon, Rectum, and Anus Secretory, Digestive, and Absorptive Functions of the Colon and Colonic Flora Probiotics, Prebiotics and the Microbiota Anoscopy, Sigmoidoscopy, and Colonoscopy Laparoscopy and Laparotomy Stool Examination Intestinal Bleeding Motility and Dysmotility of the Large Intestine Normal Defecation and Pathophysiology of Fecal Incontinence Constipation Effects of Drugs on the Colon Megacolon and Hirschsprung Disease Volvulus, Sigmoid and Cecum Diseases of the Appendix: Inflammation, Mucocele, and Tumors Diverticulosis Ulcerative Colitis Ileostomy and Colostomy Pouch Anal Anastomosis and Pouchitis Differentiating Features of Ulcerative Colitis and Crohn's Disease Crohn's Disease and Complications and Surgical Therapy Perianal Disease in Crohn's Disease Drug Therapy for Inflammatory Bowel Disease Microscopic Colitis (Lymphocytic or Collagenous Colitis) Neoplasms of the Large Bowel: Colonic Polyps and Colon Cancer Familial Adenomatous Polyposis and Polyposis Syndromes Rectal Cancer Hemorrhoids Rectal Prolapse and Procidentia Anal Fissure, Pruritus Ani, Papillitis, and Cryptitis Anorectal Abscess and Fistula Lymphogranuloma Venereum and Sexually Transmitted Proctitis Fecal Incontinence SECTION VI INFECTIOUS AND PARASITIC DISEASES OF THE ALIMENTARY TRACT Human Immunodeficiency Virus and the Gastrointestinal Tract Infectious Esophagitis Typhoid Fever (Paratyphoid Fever, Enteric Fever) Food Poisoning and Enteric Pathogens Clostridium difficile and Antibiotic-Associated Diarrhea Gastrointestinal Tuberculosis Abdominal Actinomycosis Amebiasis Giardia lamblia and Other Protozoan Infections Intestinal Helminths: Trichuriasis Enterobiasis Ascariasis Strongyloidiasis Hookworm Disease (Necatoriasis and Ancylostomiasis) Tapeworms (Cestodes) Other Helminth Infections: Trichinella spiralis and Flukes SECTION VII PANCREAS Development and Anatomy of the Pancreas Pancreatic Ducts and Exocrine and Endocrine Organs Pancreatic Physiology Cystic Fibrosis Acute Pancreatitis Chronic Pancreatitis Pancreatic Cancer Cystic Neoplasms of the Pancreas Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) SECTION VIII GALLBLADDER AND BILE DUCTS Anatomy and Function of the Gallbladder Gallstone Acute Cholecystiti Cholecystitis: Complications C. S. Pitchumoni Chronic Cholecystitis Choledocholithiasis and Cholangitis Sphincter of Oddi Dysfunction Preiampullary Cancer Gallbladder Carcinoma Cholangiocarcinoma SECTION IX LIVER Anatomy of the Liver Liver Function Tests Prothrombin Formation Bilirubin and Bile Acid Metabolism Clinical Manifestations of Cirrhosis Physical Diagnosis of Liver Disease Causes of Portal Hypertension Ascites Hepatic Encephalopathy Hepatorenal Syndrome Variceal Bleeding Transjugular Intrahepatic Portosystemic Shunt Liver Biopsy Hepatic Necrosis Cirrhosis Imaging Studies of the Liver Alcoholic Liver Disease Nonalcoholic Fatty Liver Disease and Seatohepatitis Extrahepatic Biliary Obstruction Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Autoimmune Hepatitis Acute Viral Hepatitis (Hepatitis A, D, E) Hepatitis B Hepatitis C Hepatitis Caused by Other Viruses Hepatotoxicity Disorders of Bilirubin Transport a-Antitrypsin Deficiency Hereditary Hemochromatosis Liver Disease in Pregnancy Benign Liver Tumors Granulomatous Liver Diseases Wilson Disease Hepatocellular Carcinoma Liver Transplantation Other Infections of the Liver: Amebiasis, Spirochetes, Actinomycosis, Echicoccosis, Schistosomiasis Vascular Disorders of the Liver Bile Duct Cancer Metastatic Cancer Hepatic Trauma SECTION X NUTRITION AND GASTROINTESTINAL DISEASE Dietary and Nutritional Assessment Macronutrients and Energy Micronutrient and Vitamin Deficiency Enteral Nutrition Dietary Fiber Parenteral Nutrition Malnutrition Obesity and Its Treatment Gastrointestinal Diseases Related to Nutrition

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Book SynopsisTable of ContentsPart I Biology of the Gastrointestinal Tract 1. Chapter 1 Documents Here: Cellular Growth and Neoplasia 2. Mucosal Immunology and Inflammation 3. The Enteric Microbiota 4. Gastrointestinal Hormones and Neurotransmitters Part II Nutrition in Gastroenterology 5. Chapter 2 Documents Here: Nutritional Principles and the Assessment of the Gastroenterology Patient 6. Nutritional Management 7. Obesity 8. Surgical and Endoscopic Treatment of Obesity 9. Feeding and Eating Disorders 10. Food Allergies Part III Symptoms, Signs, and Biopsychosocial Issues 11. Chapter 3 Documents here: Acute Abdominal Pain 12. Chronic Abdominal Pain 13. Symptoms of Esophageal Disease 14. Dyspepsia 15. Nausea and Vomiting 16. Diarrhea 17. Intestinal Gas 18. Fecal Incontinence 19. Constipation 20. Gastrointestinal Bleeding 21. Jaundice 22. Biopsychosocial Issues in Gastroenterology 23. Factitious Gastrointestinal Disease Part IV Topics Involving Multiple Organs 24. Chapter 4 Documents here: Oral Diseases and Oral Manifestations of Gastrointestinal and Liver Diseases 25. Cutaneous Manifestations of Gastrointestinal and Liver Diseases 26. Diverticula of the Pharynx, Esophagus, Stomach, and Small Intestine 27. Abdominal Hernias and Gastric Volvulus 28. Foreign Bodies, Bezoars, and Caustic Ingestions 29. Abdominal Abscesses and Gastrointestinal Fistulas 30. Eosinophilic Disorders of the Gastrointestinal Tract 31. Protein-Losing Gastroenteropathy 32. Gastrointestinal Lymphomas 33. Gastrointestinal Stromal Tumors (GISTs) 34. Neuroendocrine Tumors 35. Gastrointestinal Consequences of Infection with Human Immunodeficiency Virus" 36. Gastrointestinal and Hepatic Complications of Solid Organ and Hematopoietic Cell Transplantation 37. Gastrointestinal and Hepatic Manifestations of Systemic Diseases 38. Vascular Lesions of the Gastrointestinal Tract 39. Surgical Peritonitis and Other Diseases of the Peritoneum, Mesentery, Omentum, and Diaphragm 40. Gastrointestinal and Hepatic Disorders in the Pregnant Patient 41. Radiation Injury 42. Preparation for and Complications of GI Endoscopy Part V Esophagus 43. Chapter 5 Documents here: Anatomy, Histology, Embryology, and Developmental Anomalies of the Esophagus 44. Esophageal Neuromuscular Function and Motility Disorders 45. Esophageal Disorders Caused by Medications, Trauma, and Infection 46. Gastroesophageal Reflux Disease 47. Barrett's Esophagus 48. Esophageal Tumors Part VI Stomach and Duodenum 49. Chapter 6 documents here: Anatomy, Histology and Developmental Anomalies of the Stomach and Duodenum 50. Gastric Neuromuscular Function and Neuromuscular Disorders 51. Gastric Secretion 52. Helicobacter pylori, Gastritis, and Gastropathies 53. Peptic Ulcer Disease 54. Adenocarcinoma of the Stomach and Other Gastric Tumors Part VII Pancreas 55. Chapter 7 documents here: Anatomy, Histology, Embryology, and Developmental Anomalies of the Pancreas 56. Pancreatic Secretion 57. Hereditary, Familial, and Genetic Disorders of the Pancreas and Pancreatic Disorders in Childhood 58. Acute Pancreatitis 59. Chronic Pancreatitis 60. Pancreatic Cancer, Cystic Pancreatic Neoplasms, and Other Nonendocrine Pancreatic Tumors 61. Endoscopic Treatment of Pancreatic Disease Part VIII Biliary Tract 62. Chapter 8 documents here: Anatomy, Histology, Embryology, Developmental Anomalies, and Pediatric Disorders of the Biliary Tract 63. Biliary Tract Motor Function and Dysfunction 64. Bile Secretion and the Enterohepatic Circulation 65. Gallstone Disease 66. Treatment of Gallstone Disease 67. Acalculous Biliary Pain, Acute Acalculous Cholecystitis, Cholesterolosis, Adenomyomatosis, and Gallbladder Polyps 68. Primary and Secondary Sclerosing Cholangitis 69. Tumors of the Bile Ducts, Gallbladder, and Ampulla 70. Endoscopic and Radiologic Treatment of Biliary Disease Part IX Liver 71. Chapter 9 Documents Here: Embryology, Anatomy, Histology, and Developmental Anomalies of the Liver 72. Liver Physiology and Energy Metabolism 73. Liver Chemistry and Function Tests 74. Overview of Cirrhosis 75. Hemochromatosis 76. Wilson Disease 77. Other Inherited Metabolic Disorders of the Liver 78. Hepatitis A 79. Hepatitis B 80. Hepatitis C 81. Hepatitis D 82. Hepatitis E 83. Hepatitis Caused by Other Viruses 84. Bacterial, Parasitic, and Fungal Infections of the Liver, including Liver Abscess 85. Vascular disorders of liver 86. Alcoholic Liver Disease 87. Nonalcoholic Fatty Liver Disease 88. Liver Disease Caused by Drugs 89. Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements 90. Autoimmune Hepatitis 91. Primary Biliary Cholangitis 92. Portal Hypertension and Variceal Bleeding 93. Ascites and Spontaneous Bacterial Peritonitis 94. Hepatic Encephalopathy, Hepatorenal Syndrome, Hepatopulmonary Syndrome, and Other Systemic Complications of Liver Disease 95. Acute Liver Failure 96. Hepatic Tumors and Cysts 97. Liver Transplantation Part X Small and Large Intestine 98. Chapter 10 documents here: Anatomy, Histology, Embryology, and Developmental Anomalies of the Small and Large Intestine 99. Small Intestinal Motor and Sensory Function and Dysfunction 100. Colonic Motor and Sensory Function and Dysfunction 101. Intestinal Electrolyte Absorption and Secretion 102. Digestion and Absorption of Carbohydrates, Fats, and Proteins 103. Intestinal Digestion and Absorption of Micronutrients 104. Maldigestion and Malabsorption 105. Small Intestinal Bacterial Overgrowth 106. Short Bowel Syndrome 107. Celiac Disease 108. Tropical Diarrhea and Malabsorption 109. Whipple's Disease 110. Infectious Enteritis and Proctocolitis 111. Food Poisoning 112. Clostridium difficile Infection 113. Intestinal Protozoa 114. Intestinal Worms 115. IBD 1: Epidemiology, Pathogenesis and Diagnosis of Inflammatory Bowel Diseases 116. IBD 2: Management of Inflammatory Bowel Diseases 117. Ileostomy, Colostomy, and Pouches 118. Intestinal Ischemia 119. Intestinal Ulcerations 120. Appendicitis 121. Diverticular Disease of the Colon 122. Irritable Bowel Syndrome 123. Intestinal Obstruction 124. Ileus and Pseudo-obstruction 125. Tumors of the Small Intestine 126. Colonic Polyps and Polyposis Syndromes 127. Colorectal Cancer 128. Other Diseases of the Colon 129. Anal Diseases Part XI Additional Treatments for Patients with Gastrointestinal and Liver Disease 130. Chapter 11 documents here: Probiotics 131. Complementary and Alternative Medicine 132. Palliative and End-of-Life Care

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Book SynopsisTable of ContentsSection I: Basics of Endoscopic Ultrasonography 1 Principles of Ultrasound 2 Equipment 3 Training and Simulators 4 Indications, Preparation, and Adverse Effects 5 New Techniques in EUS: Multiparametric Endoscopic Ultrasound Imaging Section II: Mediastinum 6 How to Perform an EUS Examination of the Esophagus and Mediastinum 7 Endoscopic Ultrasonography in Esophageal and Gastric Cancer 8 Endoscopic Ultrasound in the Evaluation of Posterior Mediastinal Lesions and Lung Cancer Section III: Stomach 9 How to Perform an EUS Examination of the Stomach 10 Subepithelial Lesions Section IV: Pancreas and Biliary Tree 11 How to Perform an Endoscopic Ultrasonography Examination of the Pancreas, Bile Duct,and Liver 12 EUS in Inflammatory Diseases of the Pancreas 13 Endoscopic Ultrasound and Pancreatic Tumors 14 Endoscopic Ultrasonography in the Evaluation of Pancreatic Cysts 15 EUS in Bile Duct, Gallbladder, and Ampullary Lesions Section V: Anorectum 16 How to Perform Anorectal Endoscopic Ultrasonography 17 Endoscopic Ultrasonography in Rectal Cancer 18 Evaluation of the Anal Sphincter by Anal Endosonography Section VI: Endoscopic Ultrasonography- Guided Tissue Acquisition 19 How to Perform Endoscopic Ultrasonography- Guided Fine-Needle Aspiration and Fine-Needle Biopsy

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Book SynopsisTable of Contents1 Maturation of Motor Function: Clinical Implications 2 Intestinal Mucosal Immunity 3 Microbiome and Multiomics of the Developing Intestine: Nutritional and Environmental Perturbations 4 The Brain-Gut-Microbiota Axis 5 Trophic Factors in the Neonatal Gastrointestinal Tract 6 The Liver and Cholestasis (Treatment and Prevention) 7 Monitoring of Feeding Tolerance in Preterm Infants 8 Human Milk Bioactives and Roles in the GI Tract 9 Donor Milk Nutrition for the Preterm Infant: Current Standards, Uses, and Transitions 10 Different Forms of Intestinal Injury: Moving Beyond NEC 11 Science-Based Strategies for Providing Nutrition for High-Risk Neonates 12 International Perspective: Management of Nutrition in Preterm Infants in Settings With Limited Resources 13 The Future of Neonatal Nutrition: Further Research and Investment, New Products 14 GI Surgical Conditions in the NICU 15 Multiomic-Based Therapeutics: The Future Index

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Book SynopsisTable of ContentsPART I Symptoms and Signs 1 Gastroesophageal Reflux Disease 2 Dysphagia 3 Hiccups 4 Acute Abdominal Pain 5 Chronic Abdominal Pain 6 Chronic Nausea and Vomiting 7 Acute Vomiting 8 Dyspepsia 9 Jaundice 10 Abnormal Weight Loss 11 Acute Diarrhea 12 Chronic Diarrhea 13 Constipation 14 Fecal Incontinence 15 Upper Gastrointestinal Bleeding 16 Severe Hematochezia 17 Suspected Small Bowel Bleeding 18 Iron Deficiency Anemia 19 Foreign Body Ingestion 20 Caustic Ingestions PART II Specific Gastrointestinal Disorders 21 Barrett's Esophagus 22 Achalasia 23 Eosinophilic Esophagitis 24 Esophageal Motility Disorders 25 Helicobacter pylori Infection 26 Gastroparesis 27 Zollinger-Ellison Syndrome 28 Gastric Intestinal Metaplasia 29 Elevated Alkaline Phosphatase Level 30 Elevated Transaminases 31 Drug-Induced Liver Injury (DILI) 32 Management of Hepatitis B 33 Treatment of Hepatitis B during Pregnancy 34 Management of Hepatitis C 35 Primary Sclerosing Cholangitis 36 Primary Biliary Cholangitis 37 Hemochromatosis 38 Wilson Disease 39 Alcoholic Hepatitis 40 Autoimmune Hepatitis 41 Nonalcoholic Fatty Liver Disease 42 Prophylaxis of Esophageal Variceal Bleeding 43 Esophageal Variceal Bleeding 44 Gastric Varices 45 Chronic Bleeding From Portal Hypertension 46 Acute Kidney Injury in Cirrhosis 47 Hepatic Encephalopathy 48 Portal Vein Thrombosis in Cirrhosis 49 Ascites 50 Spontaneous Bacterial Peritonitis 51 Hepatic Mass 52 Liver Lesions in Cirrhosis 53 Hepatocellular Carcinoma 54 Suspected Choledocholithiasis 55 Sphincter of Oddi Dysfunction 56 Choledochal Cysts 57 Acute Pancreatitis 58 Chronic Pancreatitis 59 Pancreatic Cysts 60 Celiac Disease 61 Short Bowel Syndrome 62 Microscopic Colitis 63 Acute Colonic Pseudo-Obstruction 64 Irritable Bowel Syndrome 65 Defecation Disorders 66 Acute Severe Ulcerative Colitis 67 Treatment of Ulcerative Colitis 68 Crohn's Disease 69 Management of Crohn's Disease in Pregnancy 70 Postoperative Management of Crohn's Disease 71 Biologic Therapy in Inflammatory Bowel Disease 72 Surveillance of Colorectal Neoplasia in Inflammatory Bowel Disease 73 Colonic Ischemia 74 Immune Checkpoint Inhibitors Colitis 75 Clostridioides difficile Infection 76 Colon Polyp Surveillance 77 Malignant Colorectal Polyps 78 Lynch Syndrome 79 Rectal Neuroendocrine Tumors 80 Appendiceal Neuroendocrine Tumors Index

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Book SynopsisThe brain-gut connection has been increasingly implicated in biopsychosocial well-being. While there are numerous factors that directly and indirectly impact on how the gut and the brain interact, there is a growing awareness that gastrointestinal conditions need to be viewed and treated as part of a multidisciplinary approach. Psychogastroenterology for Adults: A Handbook for Mental Health Professionals is the first book to provide mental health professionals with an evidence-based, practical guide for working with patients living with gastrointestinal conditions.Timely and accessibly written, this book provides a unique, comprehensive introduction to psychogastroenterology, offering a step-by-step guide to evidence-based psychological treatment protocols. Broad in scope and expertise, the book is divided into four parts. It opens with an overview of the field, moving on to outline psychological concerns and conditions in gastroenterological (GI) cohorts. Further, it covers various approaches to psychogastroenterology, including psychopharmacological and eHealth practices. In closing, the book looks to the future, providing guidance on supervision in psychogastroenterology, and exploring challenges in the field. Written by experts in the field, this book will be an indispensable resource for those who wish to enhance their knowledge and practice of psychogastroenterology in the mental health profession, including psychologists, psychiatrists, psychosomatic medicine specialists, nurses and social workers.Trade Review"The brain-gut axis is one of the most important clinical advances within the field of gastroenterology. This understanding involves more than just knowledge of the GI tract. Drs. Knowles, Keefer and Mikocka-Walus are the thought leaders who have developed the burgeoning field of Psychogastroenterology and their qualifications to communicate this growing body of knowledge is well demonstrated in this highly informative and innovative book. I highly recommend Psychogastroenterology as a resource to behavioural scientists, clinicians and physicians working in the field of GI disorders."- Professor Emeritus Douglas A. Drossman, MD, AGAF; President of the Rome Foundation; Professor Emeritus of Medicine and Psychiatry; Center for Functional GI Disorders, University of North Carolina at Chapel Hill, United States of America "Brain-gut (or gut-brain) disorders are extremely common affecting up to one in three people globally. Frequently these chronic gut disorders are accompanied by anxiety or depression, and they are often highly morbid impacting quality of life, relationships, work and sleep. Mental health professionals play a very important role in management but in my experience many clinicians struggle to identify a local mental health professional to refer to, because relatively few have specifically trained in or have a special interest in the field despite the high disease burden. This outstanding handbook, edited by three leading experts in the field, is therefore very timely, and provides an excellent and practical users guide for not only mental health professionals but also others who deliver health care to patients with gut disorders including specialists and general practitioners." - Laureate Professor Nicholas J. Talley, AC, MBBS (Hons.) (NSW), MD (NSW), PhD (Syd), MMedSci (Clin Epi)(Newc.), FRACP, FAFPHM, FAHMS, FRCP (Lond. & Edin.), FACP, FACG, AGAF, FAMS, FRCPI (Hon), GAICD; Pro Vice-Chancellor, Global Research, University of Newcastle, Australia; Editor-in-Chief, Medical Journal of Australia; Senior Staff Specialist, John Hunter Hospital, Newcastle, Australia; Director, Priority Research Centre for Digestive Health and Neurogastroenterology, University of Newcastle, Australia; Professor of Medicine and Professor of Epidemiology, Mayo Clinic, Rochester, MN, USA; Adjunct Professor, University of North Carolina, NC, USA; Foreign Guest Professor, Karolinska Institutet, Stockholm, Sweden"Every human being, healthy or otherwise, knows from personal experience that there is a link between what is going in their head and the state of their gastrointestinal system. Consequently, it is extraordinary that the potential for this link to be a therapeutic target has been largely ignored until relatively recently. Furthermore, when a modality such as hypnotherapy is deployed against this link, it is often dismissed as quackery or some form of placebo effect. The care of patients with gastrointestinal disorders requires a team effort from clinicians, dieticians, physiologists and preferably psychologists. However, psychologists with a training in gastroenterology are in short supply but hopefully this should change with the advent of a speciality called psychogastroenterology. This book will provide those individuals wanting to go into this exciting area with a first-class grounding on the subject with the bonus of also giving them an insight into the structure of the gastrointestinal system as well as how it works. Consequently, this book is essential reading for anybody interested in the subject of psychogastroenterology." - Professor Peter J. Whorwell, BSc, MD, PhD, FRCP; Professor of Medicine and Gastroenterology, University of Manchester; Director of the Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom "Dr’s Knowles, Keefer, and Mikocka-Walus have brought together a group of world experts in Psychogastroenterology who share their tricks of the trade. A necessary read for all interested in utlilising the brain-gut strategies to treat gastrointestinal conditions and associated psychological distress." - Professor Silvio Danese, MD, PhD; Head, IBD Center, Department of Gastroenterology Istituto Clinico Humanitas​, and President of the European Crohn's and Colitis Organisation, Vienna, Austria"Many physicians find patients with gastrointestinal disorders to be challenging and yes, at times exasperating. However, some derive great satisfaction from working together with these patients to improve their lives. These physicians are also aware of the critical importance of psychogastroenterology, which is why this excellent compendium edited by Drs. Knowles, Keefer, and Mikocka-Walus is essential reading for mental health professionals, but also to all physicians who treat these patients, regardless of their specialization." - Professor Ami D. Sperber, MD, MSPH, AGAF; Professor Emeritus of Medicine; Member, Rome Foundation Board of Directors; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"There is increasing evidence of the importance of the brain-gut axis in gastrointestinal disease and gastrointestinal symptoms. Clinicians caring for persons with gastrointestinal disorders have increasingly recognized the responsibility they have to inquire as to patients’ mental health status and the need to incorporate mental health disease management in their overall treatment plans. Knowles, Keefer and Mikocka-Walus have recognized the need for greater discussion and management advice for mental health professionals in the field of gastrointestinal diseases as they are increasingly called upon to participate in the care of these patients. Knowles, Keefer and Mikocka-Walus have assembled a superb handbook with an acclaimed international roster of authors that meticulously reviews the management of mental health disorders in gastrointestinal diseases." - Professor Charles N Bernstein, MD, FRCPC; Distinguished Professor of Medicine; Director, University of Manitoba IBD Clinical and Research Centre; Bingham Chair in Gastroenterology, Winnipeg, Canada"I highly recommend this ground-breaking and comprehensive practical guide to psychogastroenterology to any mental health professional treating adults with gastrointestinal health problems. It is an essential resource in this clinical domain, and one that is highly readable, amazingly broad in scope, and admirably grounded in current empirical knowledge. Filled with innumerable pearls of wisdom, illustrations, pragmatic tips, forms, reference tables, and handouts, this is not a book you will read once and then put aside, but rather one that you will want to keep within reach for guidance in your everyday clinical practice."- Professor Olafur S. Palsson, Psy.D.; Professor of Medicine, University of North Carolina at Chapel Hill, United States of America "This is a must-have go-to resource for health professionals providing psychological care for those with gastrointestinal illnesses. The medical background on GI conditions ranging from dyspepsia to IBD and colon cancer sets the stage for the evidence-based guidance on relevant psychological treatments. Practical and informative, the book is a superb entrance into the world of psychogastroenterology."- Professor Lesley Graff, PhD, CPsych; Professor & Head, Clinical Health Psychology Department, Max Rady College of Medicine University of Manitoba & Medical Director, Clinical Health Psychology Program Winnipeg Regional Health Authority Canada, Winnipeg, Canada"The brain-gut axis is one of the most important clinical advances within the field of gastroenterology. This understanding involves more than just knowledge of the GI tract. Drs. Knowles, Keefer and Mikocka-Walus are the thought leaders who have developed the burgeoning field of Psychogastroenterology and their qualifications to communicate this growing body of knowledge is well demonstrated in this highly informative and innovative book. I highly recommend Psychogastroenterology as a resource to behavioural scientists, clinicians and physicians working in the field of GI disorders."- Professor Emeritus Douglas A. Drossman, MD, AGAF; President of the Rome Foundation; Professor Emeritus of Medicine and Psychiatry; Center for Functional GI Disorders, University of North Carolina at Chapel Hill, United States of America "Brain-gut (or gut-brain) disorders are extremely common affecting up to one in three people globally. Frequently these chronic gut disorders are accompanied by anxiety or depression, and they are often highly morbid impacting quality of life, relationships, work and sleep. Mental health professionals play a very important role in management but in my experience many clinicians struggle to identify a local mental health professional to refer to, because relatively few have specifically trained in or have a special interest in the field despite the high disease burden. This outstanding handbook, edited by three leading experts in the field, is therefore very timely, and provides an excellent and practical users guide for not only mental health professionals but also others who deliver health care to patients with gut disorders including specialists and general practitioners." - Laureate Professor Nicholas J. Talley, AC, MBBS (Hons.) (NSW), MD (NSW), PhD (Syd), MMedSci (Clin Epi)(Newc.), FRACP, FAFPHM, FAHMS, FRCP (Lond. & Edin.), FACP, FACG, AGAF, FAMS, FRCPI (Hon), GAICD; Pro Vice-Chancellor, Global Research, University of Newcastle, Australia; Editor-in-Chief, Medical Journal of Australia; Senior Staff Specialist, John Hunter Hospital, Newcastle, Australia; Director, Priority Research Centre for Digestive Health and Neurogastroenterology, University of Newcastle, Australia; Professor of Medicine and Professor of Epidemiology, Mayo Clinic, Rochester, MN, USA; Adjunct Professor, University of North Carolina, NC, USA; Foreign Guest Professor, Karolinska Institutet, Stockholm, Sweden"Every human being, healthy or otherwise, knows from personal experience that there is a link between what is going in their head and the state of their gastrointestinal system. Consequently, it is extraordinary that the potential for this link to be a therapeutic target has been largely ignored until relatively recently. Furthermore, when a modality such as hypnotherapy is deployed against this link, it is often dismissed as quackery or some form of placebo effect. The care of patients with gastrointestinal disorders requires a team effort from clinicians, dieticians, physiologists and preferably psychologists. However, psychologists with a training in gastroenterology are in short supply but hopefully this should change with the advent of a speciality called psychogastroenterology. This book will provide those individuals wanting to go into this exciting area with a first-class grounding on the subject with the bonus of also giving them an insight into the structure of the gastrointestinal system as well as how it works. Consequently, this book is essential reading for anybody interested in the subject of psychogastroenterology." - Professor Peter J. Whorwell, BSc, MD, PhD, FRCP; Professor of Medicine and Gastroenterology, University of Manchester; Director of the Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom "Dr’s Knowles, Keefer, and Mikocka-Walus have brought together a group of world experts in Psychogastroenterology who share their tricks of the trade. A necessary read for all interested in utlilising the brain-gut strategies to treat gastrointestinal conditions and associated psychological distress." - Professor Silvio Danese, MD, PhD; Head, IBD Center, Department of Gastroenterology Istituto Clinico Humanitas​, and President of the European Crohn's and Colitis Organisation, Vienna, Austria"Many physicians find patients with gastrointestinal disorders to be challenging and yes, at times exasperating. However, some derive great satisfaction from working together with these patients to improve their lives. These physicians are also aware of the critical importance of psychogastroenterology, which is why this excellent compendium edited by Drs. Knowles, Keefer, and Mikocka-Walus is essential reading for mental health professionals, but also to all physicians who treat these patients, regardless of their specialization." - Professor Ami D. Sperber, MD, MSPH, AGAF; Professor Emeritus of Medicine; Member, Rome Foundation Board of Directors; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"There is increasing evidence of the importance of the brain-gut axis in gastrointestinal disease and gastrointestinal symptoms. Clinicians caring for persons with gastrointestinal disorders have increasingly recognized the responsibility they have to inquire as to patients’ mental health status and the need to incorporate mental health disease management in their overall treatment plans. Knowles, Keefer and Mikocka-Walus have recognized the need for greater discussion and management advice for mental health professionals in the field of gastrointestinal diseases as they are increasingly called upon to participate in the care of these patients. Knowles, Keefer and Mikocka-Walus have assembled a superb handbook with an acclaimed international roster of authors that meticulously reviews the management of mental health disorders in gastrointestinal diseases." - Professor Charles N Bernstein, MD, FRCPC; Distinguished Professor of Medicine; Director, University of Manitoba IBD Clinical and Research Centre; Bingham Chair in Gastroenterology, Winnipeg, Canada"I highly recommend this ground-breaking and comprehensive practical guide to psychogastroenterology to any mental health professional treating adults with gastrointestinal health problems. It is an essential resource in this clinical domain, and one that is highly readable, amazingly broad in scope, and admirably grounded in current empirical knowledge. Filled with innumerable pearls of wisdom, illustrations, pragmatic tips, forms, reference tables, and handouts, this is not a book you will read once and then put aside, but rather one that you will want to keep within reach for guidance in your everyday clinical practice."- Professor Olafur S. Palsson, Psy.D.; Professor of Medicine, University of North Carolina at Chapel Hill, United States of America "This is a must-have go-to resource for health professionals providing psychological care for those with gastrointestinal illnesses. The medical background on GI conditions ranging from dyspepsia to IBD and colon cancer sets the stage for the evidence-based guidance on relevant psychological treatments. Practical and informative, the book is a superb entrance into the world of psychogastroenterology." - Professor Lesley Graff, PhD, CPsych; Professor & Head, Clinical Health Psychology Department, Max Rady College of Medicine University of Manitoba & Medical Director, Clinical Health Psychology Program Winnipeg Regional Health Authority Canada, Winnipeg, CanadaTable of ContentsForeword by William E. Whitehead; Part 1: Introduction to gastrointestinal physiology and conditions, the brain-gut axis, and working within health care teams; Chapter 1: The gastrointestinal tract: A brief introduction to healthy digestion by Dr Christopher F.D Li Wan Suen and Dr Peter De Cruz; Chapter 2: The upper gastrointestinal tract, common conditions and recommended treatments by Professor Geoff Hebbard; Chapter 3: The lower gastrointestinal tract, common conditions and recommended treatments by Dr Rebecca Burgell and Dr Bei Ye; Chapter 4: Gastroenterological cancers and stomas by Professor Timothy Pearman and Dr Elizabeth L. Addington; Chapter 5: Stress and the brain-gut axis across the spectrum of digestive disorders by Dr Gregory Sayuk; Chapter 6: Working with gastroenterologists, health administrators, and other members of the gastrointestinal and allied health care team by Dr Sarah W. Kinsinger; Part Two: Psychological concerns and conditions in gastroenterological cohorts; Chapter 7: Common gastrointestinal investigations and psychological concerns by Dr Tuan Duong and Professor Jane M. Andrews; Chapter 8: Common psychological issues in gastrointestinal conditions by Associate Professor Antonina Mikocka-Walus, Ms Catherine Emerson, Dr Lisa Olive and Dr Simon R. Knowles; Chapter 9: Working with complex patients with gastrointestinal and psychological concerns Dr Emily Edlynn and Dr Tiffany Taft; Part Three: Psychological, psychopharmacological, and eHealth approaches in psychogastroenterology; Chapter 10: Psychological assessment, formulation, and intervention planning in gastrointestinal cohorts with psychological issues by Dr Philip Keightley and Dr Simon R. Knowles; Chapter 11: Promoting change in psychological and gastrointestinal conditions - motivational interviewing (MI) by Dr Daron A. Watts, Dr Hans R Watson and Professor Terry L. Correll; Chapter 12: Promoting change in gastrointestinal conditions - Solution-Focused Brief Therapy (SFBT) by Assistant Professor Anne Lutz and Dr Christiaan van Woerden; Chapter 13: Stress management and mindfulness-based stress reduction (MBSR) approaches to gastrointestinal conditions by Anjali U Pandit and Dr Sarah Ballou; Chapter 14: Cognitive behavioural therapy (CBT) approaches to gastrointestinal conditions by Ms Karen J. Conlon and Associate Professor Laurie Keefer; Chapter 15: Hypnosis approaches to gastrointestinal conditions by Dr Megan E. Riehl; Chapter 16: Psychodynamic-interpersonal therapy (PIT) approaches to gastrointestinal conditions by Professor Elspeth Guthrie; Chapter 17: Emerging approaches - acceptance and commitment therapy (ACT) approaches to gastrointestinal conditions by Associate Professor Nuno Ferreira; Chapter 18: Behavioural approaches to managing substance-related problems in gastrointestinal conditions by Professor Eva Szigethy and Dr Trent Emerick; Chapter 19: Psychopharmacology in gastrointestinal cohorts by Ms Elspeth Carruthers and Dr Juilan Stern; Chapter 20: The role of eHealth in psychogastroenterology by Dr Andrew McCombie and Dr Simon R. Knowles; Part 4: Supervision and future challenges in psychogastroenterology; Chapter 21: Supervision and future challenges in psychogastroenterology by Dr Simon R Knowles, Associate Professor Laurie Keefer and Associate Professor Antonina Mikocka-Walus; References; Index

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Book SynopsisA riveting investigation of inflammation—the hidden force at the heart of modern disease—and how we can prevent, treat or even reverse it

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Book SynopsisAn essential resource for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists, and all those working in the field of hepatocellular carcinoma (HCC), Hepatocellular Carcinoma: A Practical Approach covers the updates and recent developments on the diagnosis, screening, and comprehensive medical and surgical management of HCC.This one-of-a-kind textbook explores all aspects of the disease using a practical, evidence-based approach, and provides step-by-step treatment guidelines that are applicable to all clinical scenarios.Highlights in the text include: screening and surveillance methods to aid in the prevention of HCC imaging technologies for accurate diagnosis, including ultrasound and PET treatment modalities for HCC, such as local ablation therapy, chemoembolization, chemotherapy, and liver resection and transplantation a discussion on novel therapies and fuTrade ReviewThis volume covers comprehensively recent developments on the diagnosis, screening and medical and surgical of HCC, and is essential reading for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists and other working in the field of HCC." - Anticancer research, April 2010 Table of ContentsEpidemiology, Pathogenesis, Surveillance, and Prevention: Epidemiology of the Hepatocellular Carcinoma. Molecular Pathogenesis. HCC Screening and Surveillance. Prevention of Hepatocellular Carcinoma. Diagnosis: Tumor Markers and Molecular Biology. Imaging of Hepatocellular Carcinoma. Staging. Management: Local Ablation Therapy. Chemotherapy and Novel Systemic Therapies. Chemoembolization, Radioembolization, and Other Novel Intra-arterial Therapies. Liver Resection. Liver Transplantation as Treatment for HCC.

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Book SynopsisAn easy-to-follow plan to regain a healthy gastrointestinal system-and relieve problems from gas to bloating to IBS. Close to 100 million Americans suffer from chronic-and sometimes very serious- gastrointestinal conditions. Prominent gastroenterologist Dr. Wesley Jones has found that virtually all digestive problems have one single underlying cause-constipation. Our modern diets and stressful lifestyles can make poor digestion such a common experience that sometimes people don't even recognize it as a problem. Here, Dr. Jones provides a proven program that has already helped thousands relieve and prevent constipation-related gastrointestinal problems for life. No one wants to talk about constipation, but millions suffer from it. Take as evidence the ubiquitous ads for Dannon's billion-dollar brand, Activia, which features Jamie Lee Curtis talking about occasional irregularity. Constipation is one of the most common gastrointestinal complaints in the United State

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Book Synopsis* Condensed, unified format for this very key topic. * Content tailored to the needs of the practicing clinician and the requirements of GI board examinations.Trade Review“This is an outstanding, succinct paperback text of the normal physiology of the digestive system written by an authoritative team of experts that is likely to become the standard reading for introductory courses to digestive system physiology. It is also a quick read for practicing gastroenterologists, surgeons, or internists who appreciate the value of understanding the cutting edge of physiologic principles of our field.” (Gastroenterology, 1 June 2015) Table of ContentsContributors, vi Preface, ix About the companion website, x 1 Structure and innervation of hollow viscera, 1Laura D. Wood & Elizabeth A. Montgomery 2 Gastrointestinal hormones in the regulation of gut function in health and disease, 15John Del Valle 3 Gastrointestinal motility, 33Ikuo Hirano & Darren Brenner 4 Gastrointestinal immunology and ecology, 46Shehzad Z. Sheikh & Scott E. Plevy 5 Gastric physiology, 58Mitchell L. Schubert 6 Structure and function of the exocrine pancreas, 78James H. Grendell 7 Absorption and secretion of fluid and electrolytes, 92Lawrence R. Schiller 8 Absorption of nutrients, 108Lawrence R. Schiller 9 Hepatic structure and function, 129Michelle T. Long & Lawrence S. Friedman 10 The splanchnic circulation, 149Peter R. Kvietys & D. Neil Granger 11 Composition and circulation of the bile, 164Allan W. Wolkoff 12 Bilirubin metabolism, 173Allan W. Wolkoff Index, 183

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Book SynopsisTurbocharge your gut health with this bold new plant-based plan.

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Book SynopsisWritten by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.Table of ContentsGenetic Susceptibility to Colorectal Cancer. Epidemiology of Colorectal Cancer. Colorectal Cancer Screening. Pathology. Familial Cancer Management. The Surgical Principles of Managing Colorectal Cancer. Adjuvant Therapy for Colorectal Cancer. The Role of Radiotherapy in the Treatment of Rectal Cancer. Hepatic Directed Therapy. Pharmacogenomics of Colorectal Cancer. Drug Development for Advanced Colorectal Cancer in the U.S.

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Book SynopsisColorectal cancer is the second-leading cause of cancer-related death in the Western World. This Second Edition analyzes the genetics, mechanisms, and development of colorectal carcinoma and supplies the latest research and recommendations on the detection, treatment, and prevention of malignancies of the colon, rectum, and anus.Table of ContentsBenign Neoplasms of the Colon and Rectum. Large Bowel Carcinoma: Screening, Surveillance, and Follow-up. Malignant Neoplasms of the Colon. Malignant Neoplasms of the Rectum. Perianal and Anal Canal Neoplasms. Anal and Transanal Techniques. Laparoscopic Colon and Rectal Surgery.

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Book SynopsisProviding an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain.Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the anatomy of the rostral nucleus of the solitary tract (rNST), and explores the properties of synaptic transmitters and neurons within that tract. The book examines the role of reflex activities and considers factors that influence how gustatory rNST neurons respond to taste stimuli. It describes the development and maturational changes the rNST undergoes and considers the challenge involved with identifying rNST neural circuits.The Role of the Nucleus of the Solitary Tract in Gustatory Processing brings together expert investigators who have contributed substantially to the current knowledge of the anatomy, physiology, and developmental biology of the solitary nucleus. This pertinent work serves as a standard reference for those involved in the field, providing ready access to past investigations and inviting practitioners to create new approaches that will advance knowledge about the central processing of gustatory information.Table of ContentsHistorical Perspectives. Anatomy of the Rostral Nucleus of the Solitary Tract. Neurotransmitters and Receptors Expressed by rNST Neurons. Reflex Connections. Neural Coding in the Rnst. Development and Plasticity of the Gustatory Portion of Nucleus of the Solitary Tract. rNST Circuits.

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Book SynopsisThis volume presents information regarding the mechanisms of protein absorption under normal and pathologic conditions, in addition to reviewing changes that occur at various stages of life. General modifiers of intestinal absorption, such as the processing of foods, the nutritional status of the individual, and disease, are explored with reference to both proteins and minerals. Inorganic macronutrients, namely calcium, magnesium and phosphorus, are discussed in relation to protein ingestion. The book also explores the concept of essential trace elements (e.g., iron, zinc, copper, and iodine) and their link to protein sufficiency. The relationship of ultratrace elements with the content of proteins in food is examined, and the book offers a fresh view of the role of certain elements, particularly zinc, on the conformation of proteins linked to DNA, hormone receptors, and gene products. Protein Nutrition and Mineral Absorption is packed with 2,300 references, 100 figures and graphs, pluTrade Review"This is a wonderful volume. It will be of great use to all of us involved in clinical nutrition and will serve as an excellent starting point for anyone wishing an introduction to this important field."-Journal of Parenteral and Enteral NutritionTable of ContentsMECHANISMS OF PROTEIN ABSORPTION. HISTORICAL PERSPECTIVE. AMINO ACID VS. OLIGOPEPTIDE ABSORPTION. SMALL PEPTIDES AS THE MAJOR SUBSTRATES OF PROTEIN ABSORPTION. ABSORPTION OF INTACT PROTEINS. REFERENCES. EFFECT OF NUTRITIONAL STATUS AND DISEASE ON PROTEIN ABSORPTION. INTRODUCTION. EFFECT OF PROTEIN DEFICIENCY ON AMINO ACID AND OLIGOPEPTIDE ABSORPTION. DIETARY AND METABOLIC REGULATION OF AMINO ACID ABSORPTION. ABSORPTION OF INTACT PROTEINS IN NUTRITIONAL DEPRIVATION. EFFECT OF MATERNAL PROTEIN RESTRICTION ON NEONATAL PROTEIN ABSORPTION. ABSORPTION OF PROTEIN IN ACQUIRED DISEASE. General Considerations. Celiac Disease (Sprue). Renal Disease. ABSORPTION OF PROTEIN IN CONGENITAL DISEASE. General Considerations. Cystinuria. Familial Protein Intolerance. Hyperdibasic Aminoaciduria. Neutral Amino Acid Malabsorption Syndromes. Iminoglycinuria. Lowe's Syndrome. Congenital Agammaglobulinemia. Peptiduria Associated with Aminopeptidase-P Deficiency. REFERENCES. DEVELOPMENTAL FACTORS IN PROTEIN AND MINERAL ABSORPTION. INTRODUCTION. ONTOGENY OF THE GASTROINTESTINAL TRACT. Morphology. Development of the Gastrointestinal Mucosal Barrier. Membrane Composition and Rheologic Properties. DEVELOPMENT OF PROTEIN ABSORPTION MECHANISMS. Enzymatic Ontogeny. The Mammalian Intestine. Ontogeny of Human Protein Absorptive Mechanisms. Ontogeny of Amino Acid and Dipeptide Absorptive Mechanisms. Hormonal Control of Enzymatic Maturation. Role of Diet in the Development of Intestinal Absorptive Function. ONTOGENY OF MINERAL ABSORPTION. General Considerations. Calcium, Magnesium, Phosphorus. Iron. Zinc and Copper. Other Elements. PROTEIN AND MINERAL ABSORPTION LATE IN LIFE. Protein. Minerals. REFERENCES. EFFECT OF FOOD SOURCES AND PROCESSING ON PROTEIN AND MINERAL ABSORPTION. GENERAL. IMPORTANCE OF FOOD SOURCES. PHYSICAL TREATMENTS. Milling, Polishing, and Other Mechanical Processes. Heating. Cooking. Dehydration. Water Extraction. Leaching. Washing. Freezing/Thawing. Osmotic Alteration. Storage (Aging). Packaging. Emulsification, Homogenization, Gellification. CHEMICAL TREATMENTS. Oxidation, Reduction. Schiff Base Formation. Maillard Reactions. Browning. Acidification. Alkalinization. Sequestration. Natural Chelating Agents. Chemical Processing with Macro-Additives: Salt, Curing. REFERENCES. CALCIUM, MAGNESIUM, AND PHOSPHORUS ABSORPTION, NUTRITIONAL STATUS AND EFFECT OF PROTEINS. NUTRITIONAL ASPECTS OF CALCIUM ABSORPTION. Calcium in Foods and Its Bioavailability. Mucosal Receptors at the Brush Border Mucosa. Transcellular Transport of Calcium. Effects of Protein Nutrition on Calcium Metabolic Balance. Protein-Calcium-Phosphorus Interactions. Osteoporosis. Overview of Calcium-Protein-Phosphate Interactions. NUTRITIONAL ASPECTS AND MECHANISMS OF MAGNESIUM ABSORPTION. Magnesium Requirements and Absorption. Protein-Energy Malnutrition and Magnesium Sufficiency. Studies Relating Protein and Magnesium Absorption and Sufficiency. Magnesium and Calcium Imbalances in Metabolic Disease. PHOSPHATE ABSORPTION, CATION BALANCE REGULATION, AND PROTEIN INTAKE. Dietary Phosphate and Intestinal Absorptive Mechanisms. The Phosphate-Calcium-Protein Connection. REFERENCES. NUTRITIONAL FACTORS, PROTEINS, AND THE ABSORPTION OF IRON AND COBALT. IRON CHEMISTRY AND DETERMINANTS OF THE SOLUBILITY OF THE ELEMENT. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF IRON. Luminal Factors. Mucosal Factors. Corporeal Factors. PROTEIN DERIVED PRODUCTS AND IRON ABSORPTION. Historical Background. Animal Proteins. Amino Acids. Peptides. PROTEIN NUTRITIONAL STATUS AND INTERACTIONS WITH IRON ABSORPTION. DEFECTS IN THE INTESTINAL ABSORPTION OF IRON. Idiopathic Hemochromatosis. Iron Malabsorption. PROTEIN AND NUTRITIONAL FACTORS IN THE ABSORPTION OF COBALT. Cobalt as a Possible Essential Trace Element. Essentiality of Cobalt and Cobalamines. Absorption of Vitamin B12 and of Cobalt. Attempts at Pharmacologic Uses of Cobalt. Toxicity of Cobalt. REFERENCES. ZINC ABSORPTION AND SUFFICIENCY AS AFFECTED BY PROTEIN AND OTHER NUTRIENTS. SIGNIFICANCE OF ZINC AS AN ESSENTIAL NUTRIENT. Requirements of Zinc by Vegetables and in the Animal Kingdom. Role of Zinc in Biological Processes. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF ZINC. Luminal and Dietary Factors. Mucosal Factors. Corporeal Factors. PROTEIN-DERIVED PRODUCTS AND ZINC ABSORPTION. Introduction. Amino Acids. Peptides. Proteins. ZINC MALABSORPTION. Congenital Conditions. Acquired Malabsorption. REFERENCES. COPPER ABSORPTION AND BODY DISTRIBUTION: ROLE OF PROTEIN AND OTHER NUTRIENTS. ROLE OF COPPER IN BIOLOGICAL SYSTEMS. Biological Roles of Copper. MECHANISMS FOR THE LUMINAL REMOVAL OF COPPER AND TISSUE DISTRIBUTION. Transport Across Membranes. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF COPPER. Ecological and Geographical Considerations. Luminal Factors. Mucosal Factors. Somatic Factors. PROTEIN-DERIVED PRODUCTS AND COPPER ABSORPTION. Amino Acid Participation in Copper Transport Mechanisms. Effect of Proteins and Protein Breakdown Products. INTERACTION OF OTHER ELEMENTS ON COPPER ABSORPTION. Inhibition of Copper Absorption by Zinc. Copper-Zinc Imbalance, Cholesterol, and Chronic Degenerative Diseases. GENETIC DISEASES OF COPPER ABSORPTION AND HOMEOSTASIS. Defects in Copper Uptake, Distribution, and Excretion. REFERENCES. NUTRITIONAL, ENVIRONMENTAL, AND PHYSIOLOGIC FACTORS AFFECTING SELENIUM, CHROMIUM, AND NICKEL SUFFICIENCY. SELENIUM. Selenium as a Nutrient and as a Potential Toxic Agent. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF SELENIUM. SELENIUM ADSORPTION FROM HIGH PORTEIN PRODUCTS. CHROMIUM. Chromium Chemistry and the Evidence of Nutritional Essentiality. Chromium Absorption and Tissue Distribution. Biological Roles of Chromium. Chromium Nutrition in Protein-Energy Malnutrition, Stress, and TPN. NICKEL. REFERENCES. NUTRITIONAL STATUS AND THE EFFECT OF PROTEIN AND OTHER FOODSTUFFS ON THE ABSORPTION OF MANGANESE, MOLYBDENUM, AND VANADIUM. MANGANESE. Role of Manganese in Biological Processes. Nutritional Requirements in Man and Animals. Manganese Deficiency and Toxicity. Factors Involved in the Intestinal Absorption of Manganese. Protein-Derived Products and Manganese Absorption. MOLYBDENUM. Occurrence of Molybdenum in Nature. Its Passage Through the Food Chain. Role of Molybdenum in Biological Processes. Nutritional Requirements in Man and Animals. Molybdenum Deficiency and Toxicity. Factors Involved in the Intestinal Absorption of Molybdenum. Protein-Derived Products and Molybdenum Absorption. VANADIUM. Role of Vanadium in Biological Processes. Intestinal Absorption of Vanadium. REFERENCES. THE ABSORPTION OF ARSENIC, BORON, SILICON, ALUMINUM, TIN, IODINE, AND FLUORINE: INTERACTIONS WITH PROTEINS AND OTHER NUTRIENTS. NUTRIENT VARIABLES AND THE ABSORPTION OF ARSENIC. Man and Its Relationship with Arsenic. Presentation of the Element in Nature. Arsenic as an Essential Trace Element. Role of Arsenic in Biological Processes. Arsenic in the Food Chain. Absorption of Arsenic. Metabolism of Protein and Amino Acids and Arsenic Nutrition. BIOLOGICAL AND NUTRITIONAL FACTORS IN BORON SUFFICIENCY. Boron in Nature and Its Role in Biological Processes. Boron in the Food Chain and Metabolic Fate of Ingested Boron. Metabolic Effects of Boron. Interaction with Vitamin D and Other Minerals. Role of Certain Amino Acids. SILICON AS A NUTRIENT. INTERACTIONS WITH PROTEINS AND OTHER DIETARY PRODUCTS. Silicon in Nature and in the Human Food Chain. Biological Role of Silicon. Interaction of Silicon with Other Nutrients. NUTRITIONAL AND TOXIC ASPECTS OF ALUMINUM IN THE DIET AND THE ENVIRONMENT. Aluminum in Nature and in the Food Chain. Intestinal Absorption of Aluminum. Toxicity of Aluminum. Factors Affecting the Oral Absorption of Aluminum. TIN IN THE DIET AND THE ENVIRONMENT. ITS INTERACTION WITH OTHER NUTRIENTS. Tin in Nature and in the Food Chain. The Question of Tin Essentiality. Intestinal Absorption of Tin. Interaction of Tin with Other Nutrients. PROTEIN AND OTHER NUTRITIONAL FACTORS IN THE METABOLISM AND ABSORPTION OF IODINE. Iodine in Nature. Chemical Characteristics. Role and Metabolism of Iodine. Essentiality of Iodine. Requirements. Nutritional Deficit and Toxicity. Iodine in Foods. Relation with Nutritional Status and Protein Sufficiency. NUTRITIONAL FACTORS IN THE ABSORPTION OF FLUORINE. Role of Fluorine Compounds in Calcified Tissue and Dental Integrity. Possible Essentiality of Fluorine. Metabolic Effects. Fluorine in the Diet. Absorption and Excretion. Relationship of Fluorine with Macronutrients. Interactions with Other Minerals. REFERENCES. "FINGERS", "KNUCKLES", "HANDS", "FISTS", "SIGNATURES", AND OTHER STRUCTURAL MOTIFS IN PROTEINS INVOLVING ZINC AND OTHER ESSENTIAL ELEMENTS. ZINC "FINGERS" AND THEIR ROLE IN BIOLOGICALLY ACTIVE PROTEINS. Transcription Factors. Zinc Fingers in Hormone Receptors. Finger Loops and Oncogenes. BINDING OF ZINC TO OTHER PROTEINS. DEVELOPMENT OF CATALYTIC PROPERTIES. DIFFERENT "SIGNATURES". COPPER "FISTS", METALLOTHIONEINS, AND GENE EXPRESSION. PROTEIN STRUCTURE DESIGN: "HELICES", "HANDS", "GREEK KEYS", "b-BARRELS", "SHEETS", "COILS", AND "ZIPPERS". REFERENCES. OVERVIEW.

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Book SynopsisThis important new book presents critical information on the clinical and morphological aspects of various endocrinological disorders of the gut and pancreas. Topics include a historical perspective and broad overview of the neuroendocrine component of the gut; hyperplastic proliferations of gastrointestinal endocrine cells; pancreatic endocrine cells and their non-neoplastic proliferations; tumors and lesions; and endocrine differentiation in nonendocrine tumors. The book stresses clinical and pathological aspects of these topics, as well as the pathogenesis, clinicopathological correlations, and diagnostic approaches. Gastroenterologists, pathologists, internists, surgeons, endocrinologists and others interested in endocrinological disorders of the gut and pancreas will discover that this book will be a welcome addition to your reference library.Table of ContentsNeuroendocrine Cells of GEPH Axis: Introduction and Historical Perspectives. Hyperplastic Proliferations of the Gastrointestinal Endocrine Cells. Pancreatic Endocrine Cells and Their Non-Neoplastic Proliferations. Clinically-Non-Functioning Pancreatic Endocrine Tumors. Serotonin-Producing Tumors and the Carcinoid Syndrome. Gastrin-Producing Tumors and the Z-E Syndrome. Insulin-Producing Tumors and the Insulinoma Syndrome. Glucagon-Producing Tumors and the Glucagonoma Syndrome. Somatostatin-Producing Tumors and the Somatostatinoma Syndrome. PP-Producing Tumors. The MEN Syndromes. Hormonally Active Non-Endocrine Tumors.

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Book SynopsisThe latest data on the pathogenesis of ulcer disease is presented in this text, with the emphasis that an understanding of the pathogenesis and etiology of ulcer diseases represents the most rational approach to pharmacology - the prevention and treatment of ulcer disease. Early and late biochemical and functional changes, morphologic stages of the injury and healing phases, as well as vascular factors in ulceration are highlighted. In addition, new pathogenetic elements on neuroendocrine and other endogenous modulators and circadian rhythms in ulcerogenesis are covered. The section on new pharmacology consists of several chapters presenting new animal models of gastric, small intestinal and colonic ulcers because in vivo models represent the basis to test and accurately detect new antiulcer drugs. A large series of chapters cover new drugs for ulcer prevention and treatment. This book is indispensible to investigators in basic and applied research, academic and industrial pharmacTable of ContentsPATHOGENESIS. EARLY AND LATE BIOCHEMICAL AND FUNCTIONAL CHANGES. Mechanisms of Gastrointestinal Damage by Non-Steroidal Anti-inflammatory Drugs. Correlations Between Free Radicals and Membrane-Dependent Energy Systems in Ethanol-Induced Gastric Mucosal Damage in Rats. Gastric Motility and Overall Blood Flow During Cold Restraint in the Rat. Enzymic Aspects of Cysteamine-Induced Duodenal Ulcers with Special Reference to Bicarbonate Secretion. Cysteamine is a Potent Inhibitor of Duodenal Phosphoprotein Phosphatase in Rats: Probable Role of Gastric Acid Hypersecretion. MORPHOLOGIC STAGES OF THE INJURY AND HEALING PHASES. Mechanisms of Rapid Epithelial Restitution of the Superficial Rat Gastric Mucosa after Ethanol Injury. Microscopic Analysis of Ischemic Gastric Injury in the Rat. Effects of Ulcerogens and Other Conditions on Gastric Epithelial Proliferation. Gastric Mucosal Barriers and the Actions of Aspirin. Early Cytologic Precursors to Cysteamine-Induced Duodenal Ulcer in Rats. VASCULAR FACTORS IN ULCERATION. Vascular Factors in Gastric Mucosal Injury. The Role of Microvasculature in Acute Gastric Mucosal Damage and Protection. Gastric Mucosal Microvascular Architecture and Mucosal Blood Flow in Rats During Stress. Role of Acid and Tissue Prostaglandins in the Production of Gastric Mucosal Damage. Critical Mucosal Oxygenation Level and Promotion by Acid and Histamine of Hemorrhagic Shock-Induced Gastric Ulcer in Rats. CENTRAL AND PERIPHERAL NEUROENDOCRINE INFLUENCES. Central Nervous System Action of Neuropeptides to Influence or Prevent Experimental Gastroduodenal Ulceration. Neural Influences on Gastroduodenal HCO3 Secretion. Involvement of Dopamine and Dopamine Receptors in Stress Gastric Ulceration. Somatostatin and Gastrin Secretion from the Isolated Perfused Rat Stomach: Neural and Hormonal Regulation and the Effect of the Ulcerogen, Cysteamine. Possible Involvement of Central Mechanisms in Antiulcer and Antisecretory Actions of Prostaglandins. CIRCADIAN RHYT

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Book SynopsisThis book evolved from a two-day 1993 International Symposium on Radiation and the Gastrointestinal Tract held at the Uniformed Services University of the Health Sciences, Bethesda, Maryland. This area of investigation is particularly important because of growing medical needs and the documented occurrence of accidents involving overexposure of healthy subjects/patients. Some questions have been answered through cellular and animal research-results that lead to hypotheses that have been tested through clinical protocols. In an attempt to answer the unresolved questions, basic scientists and clinicians describe the data obtained to date, present in a critical manner the consensus that has been reached, and discuss what still remains to be investigated.The book is divided into five parts: Overview and Clinical Perspective, Emesis, Motility, Diarrhea, and Behavioral Correlates of Gastrointestinal Dysfunction. Each part consists of separate discussions on the pathophysiology, the methodology, and, when applicable, the clinical relevance of the observations.The book provides helpful information to both basic scientists involved in radiobiological research and to clinicians caring for patients exposed to radiation. It also serves as an introduction to the subject for young clinical investigators interested in the field and for scientists searching for correlates between their observations and disorders of the gastrointestinal tract.Table of ContentsOverview and Clinical PerspectiveClinical Aspects of Irradiation-Induced Alimentary Tract Injury, T.R. SpitzerEmesisRadiation-Induced Emesis in Animal Models, G.L. KingDifferences in Anti-Emetic Predictability amongst 5-HT, Receptor Antagonist Drugs, P.R. BlowerClinical Trials with Ondansetron in Radiation-Induced Emesis, J.C. BrysonMotilityRadiation-Induced Gastric Dysfunction, A. DuboisPostirradiation Alterations in Small and Large Bowel Motility, M.F. Otterson and R.W. SummersNitric Oxide and Smooth Muscle Relaxation in the Intestine. Chemical and Radiation Effects Measured by EPR/SPIN Trapping, L. Steel-Goodwin and A.J. CarmichaelNeurochemical Changes in the Irradiated Brain-Gut Axis, S.B. KandasamyDiarrheaRadiation-Induced Changes to Epithelial and Non-Epithelial Tissue, K.E. Carr, S.P. Hume, R. Ettarh, E.A. Carr, and J.S. McCulloughMolecular Mechanisms of Cellular Radioresistance and Radiosensitivity, K.F. Pirollo, X. Lin, Z.M. Hao, Z. Villegas, and E.H. ChangThe Effect of Radiation on Intestinal Electrolyte Transport, P.J. Gunter-SmithNearby Shielding Influences Survival of the Irradiated Intestine, R.M. VigneulleModification of Radiation Injury to the Intestine by Eicosanoids and Thiol Radioprotectors, W.R. HansonEffect of Radioprotective Agents on Survival after Acute Intestinal Radiation Injury, J.F. Weiss, M.R. Landauer, P.J. Gunter-Smith, and W.R. HansonNutritional Support of Irradiated Intestine, V. Srinivasan and A. DuboisChemotherapy and Radiation Protection with Amifostine: Clinical Studies, E.P. Mitchell, R.D. Reynolds, D. Graden, and R.L. CapizziGastrointestinal Syndrome after Accidental Overexposure during Radiotherapy, D.F. Flynn, I. Mihalakis, T. Mauceri, and M.R. PinsBehavioral Correlates of GI DysfunctionEffects of Different Types of Radiation on Emesis and Taste Aversion Learning, B.M. Rabin and G.L. KingBehavioral Assessment of Antiemetic Drugs in Rat

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Book SynopsisMolecular and Cell Biology of the Liver features the latest research findings regarding liver structure and function. A unique feature of the book is the brief science reviews that are included in each chapter which provide essential background information to allow readers to better grasp the subject matter within a chapter. The book covers liver biology from the molecular level to groups of liver cells and explains how groups of hepatocytes interact in similar microenvironments. Other important cell types found in the liver are also examined. Illustrations ranging from electron micrographs to fully rendered drawings act as visual aids to help readers understand complex structural-functional interactions. Molecular and Cell Biology of the Liver will benefit hepatologists, gastroenterologists, cell biologists, anatomists, toxicologists, and other researchers interested in liver structure and function.Table of ContentsMolecular Aspects: Gene Activity and Regulation (G. Schreiber and A.R. Aldred). Proteins and Plasma Protein Metabolism (T. Peters, Jr.). Carbohydrates and Glycogen Metabolism (R.R. Cardell and E.L.S. Cardell). Subcellular Components: The Plasma Membrane and Intercellular Junctions (W. Hong). Receptors and Endocytosis (C.A. Casey and D.J. Tuma). Cytoskeleton (S.W. French, M. Cadrin, H. Kawahara, and K. Kachi). Peroxisomes and Lysosomes (U. Soto, S. Rapp, K. Gorgas,and W.W. Just). Parenchymal Cells: Fetal and Postnatal Growth (J. Vassy and M. Kraemer). Regeneration (A. Francavilla, T.E. Starzl, D.H. Van Thiel, M. Barone, and L. Polimeno). Functional Compartmentation of Hepotocytes (C.M. Berkowitz, E. Guibert, B. Bilir, and J.J. Gumucio). Extracellular Matrix (M. Dziadek and T. Thomas). Nonparenchymal Cells: Endothelial Cells and Kupffer Cells (R.S. McCuskey). Fat-Storing Cells (H.F.J. Hendricks, A. Brouwer,and D.L. Knook). Pit Cells (L. Bouwens). Bile Duct Cells (P. Van Eyken and V.J. Desmet).

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book SynopsisIn this greatly expanded edition of his international bestseller, Andreas Moritz reveals the most common but rarely recognized cause of illness - gallstones congesting the bile ducts in the liver. Besides leading to gallbladder diseases and gallstone attacks in at least 20 million Americans each year, in many cases, liver bile duct congestion sets the stage for even more serious, seemingly unrelated, conditions, including obesity, diabetes, heart disease, and cancer. Most adults living in the industrialized world, and especially those suffering a chronic illness, such as irritable bowel syndrome, heart disease, arthritis, multiple sclerosis, cancer, or diabetes, have in fact hundreds if not thousands of gallstones (mainly clumps of hardened bile that escape detection for they are invisible to x-rays, ultrasound, and CT scans) blocking the bile ducts of their liver. This book provides a thorough understanding of the liver and its complex functions, what causes gallstones in the liver and gallbladder, and why these stones can be held responsible for the most common diseases so prevalent in the world today. It provides the reader with the knowledge needed to recognize these stones and gives the necessary, do-it-yourself instructions to painlessly remove them in the comfort of one''s home. Packed with images, the book also gives practical guidelines on how to prevent new gallstones in both the liver and gallbladder. The liver and gallbladder flush (cleanse) has led to extraordinary improvements in health and wellness among millions of people who have already given themselves the precious gift of a strong, clean, revitalized liver. Besides providing the practical procedures to cleanse the liver, gallbladder, kidneys, and intestines, Moritz explains in great detail the origin of all types of common diseases and how to prevent or reverse them naturally. The book is packed with precious, time-tested approaches designed to return the body to a permanent state of balance and vitality; it includes a complete program of healthcare, which is primarily based on the ancient medical system of Ayurveda and the vast amount of experience Andreas Moritz has gained in the field of health restoration during the past 30 years. Moritz is the author of 15 groundbreaking books on natural health and a leading, internationally recognized, authority in the field of integrative medicine.

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