Gastroenterology Books

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Book SynopsisThe brain-gut connection has been increasingly implicated in biopsychosocial well-being. While there are numerous factors that directly and indirectly impact on how the gut and the brain interact, there is a growing awareness that gastrointestinal conditions need to be viewed and treated as part of a multidisciplinary approach. Psychogastroenterology for Adults: A Handbook for Mental Health Professionals is the first book to provide mental health professionals with an evidence-based, practical guide for working with patients living with gastrointestinal conditions.Timely and accessibly written, this book provides a unique, comprehensive introduction to psychogastroenterology, offering a step-by-step guide to evidence-based psychological treatment protocols. Broad in scope and expertise, the book is divided into four parts. It opens with an overview of the field, moving on to outline psychological concerns and conditions in gastroenterological (GI) cohorts. Further, it covers various approaches to psychogastroenterology, including psychopharmacological and eHealth practices. In closing, the book looks to the future, providing guidance on supervision in psychogastroenterology, and exploring challenges in the field. Written by experts in the field, this book will be an indispensable resource for those who wish to enhance their knowledge and practice of psychogastroenterology in the mental health profession, including psychologists, psychiatrists, psychosomatic medicine specialists, nurses and social workers.Trade Review"The brain-gut axis is one of the most important clinical advances within the field of gastroenterology. This understanding involves more than just knowledge of the GI tract. Drs. Knowles, Keefer and Mikocka-Walus are the thought leaders who have developed the burgeoning field of Psychogastroenterology and their qualifications to communicate this growing body of knowledge is well demonstrated in this highly informative and innovative book. I highly recommend Psychogastroenterology as a resource to behavioural scientists, clinicians and physicians working in the field of GI disorders."- Professor Emeritus Douglas A. Drossman, MD, AGAF; President of the Rome Foundation; Professor Emeritus of Medicine and Psychiatry; Center for Functional GI Disorders, University of North Carolina at Chapel Hill, United States of America "Brain-gut (or gut-brain) disorders are extremely common affecting up to one in three people globally. Frequently these chronic gut disorders are accompanied by anxiety or depression, and they are often highly morbid impacting quality of life, relationships, work and sleep. Mental health professionals play a very important role in management but in my experience many clinicians struggle to identify a local mental health professional to refer to, because relatively few have specifically trained in or have a special interest in the field despite the high disease burden. This outstanding handbook, edited by three leading experts in the field, is therefore very timely, and provides an excellent and practical users guide for not only mental health professionals but also others who deliver health care to patients with gut disorders including specialists and general practitioners." - Laureate Professor Nicholas J. Talley, AC, MBBS (Hons.) (NSW), MD (NSW), PhD (Syd), MMedSci (Clin Epi)(Newc.), FRACP, FAFPHM, FAHMS, FRCP (Lond. & Edin.), FACP, FACG, AGAF, FAMS, FRCPI (Hon), GAICD; Pro Vice-Chancellor, Global Research, University of Newcastle, Australia; Editor-in-Chief, Medical Journal of Australia; Senior Staff Specialist, John Hunter Hospital, Newcastle, Australia; Director, Priority Research Centre for Digestive Health and Neurogastroenterology, University of Newcastle, Australia; Professor of Medicine and Professor of Epidemiology, Mayo Clinic, Rochester, MN, USA; Adjunct Professor, University of North Carolina, NC, USA; Foreign Guest Professor, Karolinska Institutet, Stockholm, Sweden"Every human being, healthy or otherwise, knows from personal experience that there is a link between what is going in their head and the state of their gastrointestinal system. Consequently, it is extraordinary that the potential for this link to be a therapeutic target has been largely ignored until relatively recently. Furthermore, when a modality such as hypnotherapy is deployed against this link, it is often dismissed as quackery or some form of placebo effect. The care of patients with gastrointestinal disorders requires a team effort from clinicians, dieticians, physiologists and preferably psychologists. However, psychologists with a training in gastroenterology are in short supply but hopefully this should change with the advent of a speciality called psychogastroenterology. This book will provide those individuals wanting to go into this exciting area with a first-class grounding on the subject with the bonus of also giving them an insight into the structure of the gastrointestinal system as well as how it works. Consequently, this book is essential reading for anybody interested in the subject of psychogastroenterology." - Professor Peter J. Whorwell, BSc, MD, PhD, FRCP; Professor of Medicine and Gastroenterology, University of Manchester; Director of the Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom "Dr’s Knowles, Keefer, and Mikocka-Walus have brought together a group of world experts in Psychogastroenterology who share their tricks of the trade. A necessary read for all interested in utlilising the brain-gut strategies to treat gastrointestinal conditions and associated psychological distress." - Professor Silvio Danese, MD, PhD; Head, IBD Center, Department of Gastroenterology Istituto Clinico Humanitas​, and President of the European Crohn's and Colitis Organisation, Vienna, Austria"Many physicians find patients with gastrointestinal disorders to be challenging and yes, at times exasperating. However, some derive great satisfaction from working together with these patients to improve their lives. These physicians are also aware of the critical importance of psychogastroenterology, which is why this excellent compendium edited by Drs. Knowles, Keefer, and Mikocka-Walus is essential reading for mental health professionals, but also to all physicians who treat these patients, regardless of their specialization." - Professor Ami D. Sperber, MD, MSPH, AGAF; Professor Emeritus of Medicine; Member, Rome Foundation Board of Directors; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"There is increasing evidence of the importance of the brain-gut axis in gastrointestinal disease and gastrointestinal symptoms. Clinicians caring for persons with gastrointestinal disorders have increasingly recognized the responsibility they have to inquire as to patients’ mental health status and the need to incorporate mental health disease management in their overall treatment plans. Knowles, Keefer and Mikocka-Walus have recognized the need for greater discussion and management advice for mental health professionals in the field of gastrointestinal diseases as they are increasingly called upon to participate in the care of these patients. Knowles, Keefer and Mikocka-Walus have assembled a superb handbook with an acclaimed international roster of authors that meticulously reviews the management of mental health disorders in gastrointestinal diseases." - Professor Charles N Bernstein, MD, FRCPC; Distinguished Professor of Medicine; Director, University of Manitoba IBD Clinical and Research Centre; Bingham Chair in Gastroenterology, Winnipeg, Canada"I highly recommend this ground-breaking and comprehensive practical guide to psychogastroenterology to any mental health professional treating adults with gastrointestinal health problems. It is an essential resource in this clinical domain, and one that is highly readable, amazingly broad in scope, and admirably grounded in current empirical knowledge. Filled with innumerable pearls of wisdom, illustrations, pragmatic tips, forms, reference tables, and handouts, this is not a book you will read once and then put aside, but rather one that you will want to keep within reach for guidance in your everyday clinical practice."- Professor Olafur S. Palsson, Psy.D.; Professor of Medicine, University of North Carolina at Chapel Hill, United States of America "This is a must-have go-to resource for health professionals providing psychological care for those with gastrointestinal illnesses. The medical background on GI conditions ranging from dyspepsia to IBD and colon cancer sets the stage for the evidence-based guidance on relevant psychological treatments. Practical and informative, the book is a superb entrance into the world of psychogastroenterology."- Professor Lesley Graff, PhD, CPsych; Professor & Head, Clinical Health Psychology Department, Max Rady College of Medicine University of Manitoba & Medical Director, Clinical Health Psychology Program Winnipeg Regional Health Authority Canada, Winnipeg, Canada"The brain-gut axis is one of the most important clinical advances within the field of gastroenterology. This understanding involves more than just knowledge of the GI tract. Drs. Knowles, Keefer and Mikocka-Walus are the thought leaders who have developed the burgeoning field of Psychogastroenterology and their qualifications to communicate this growing body of knowledge is well demonstrated in this highly informative and innovative book. I highly recommend Psychogastroenterology as a resource to behavioural scientists, clinicians and physicians working in the field of GI disorders."- Professor Emeritus Douglas A. Drossman, MD, AGAF; President of the Rome Foundation; Professor Emeritus of Medicine and Psychiatry; Center for Functional GI Disorders, University of North Carolina at Chapel Hill, United States of America "Brain-gut (or gut-brain) disorders are extremely common affecting up to one in three people globally. Frequently these chronic gut disorders are accompanied by anxiety or depression, and they are often highly morbid impacting quality of life, relationships, work and sleep. Mental health professionals play a very important role in management but in my experience many clinicians struggle to identify a local mental health professional to refer to, because relatively few have specifically trained in or have a special interest in the field despite the high disease burden. This outstanding handbook, edited by three leading experts in the field, is therefore very timely, and provides an excellent and practical users guide for not only mental health professionals but also others who deliver health care to patients with gut disorders including specialists and general practitioners." - Laureate Professor Nicholas J. Talley, AC, MBBS (Hons.) (NSW), MD (NSW), PhD (Syd), MMedSci (Clin Epi)(Newc.), FRACP, FAFPHM, FAHMS, FRCP (Lond. & Edin.), FACP, FACG, AGAF, FAMS, FRCPI (Hon), GAICD; Pro Vice-Chancellor, Global Research, University of Newcastle, Australia; Editor-in-Chief, Medical Journal of Australia; Senior Staff Specialist, John Hunter Hospital, Newcastle, Australia; Director, Priority Research Centre for Digestive Health and Neurogastroenterology, University of Newcastle, Australia; Professor of Medicine and Professor of Epidemiology, Mayo Clinic, Rochester, MN, USA; Adjunct Professor, University of North Carolina, NC, USA; Foreign Guest Professor, Karolinska Institutet, Stockholm, Sweden"Every human being, healthy or otherwise, knows from personal experience that there is a link between what is going in their head and the state of their gastrointestinal system. Consequently, it is extraordinary that the potential for this link to be a therapeutic target has been largely ignored until relatively recently. Furthermore, when a modality such as hypnotherapy is deployed against this link, it is often dismissed as quackery or some form of placebo effect. The care of patients with gastrointestinal disorders requires a team effort from clinicians, dieticians, physiologists and preferably psychologists. However, psychologists with a training in gastroenterology are in short supply but hopefully this should change with the advent of a speciality called psychogastroenterology. This book will provide those individuals wanting to go into this exciting area with a first-class grounding on the subject with the bonus of also giving them an insight into the structure of the gastrointestinal system as well as how it works. Consequently, this book is essential reading for anybody interested in the subject of psychogastroenterology." - Professor Peter J. Whorwell, BSc, MD, PhD, FRCP; Professor of Medicine and Gastroenterology, University of Manchester; Director of the Neurogastroenterology Unit, Wythenshawe Hospital, Manchester, United Kingdom "Dr’s Knowles, Keefer, and Mikocka-Walus have brought together a group of world experts in Psychogastroenterology who share their tricks of the trade. A necessary read for all interested in utlilising the brain-gut strategies to treat gastrointestinal conditions and associated psychological distress." - Professor Silvio Danese, MD, PhD; Head, IBD Center, Department of Gastroenterology Istituto Clinico Humanitas​, and President of the European Crohn's and Colitis Organisation, Vienna, Austria"Many physicians find patients with gastrointestinal disorders to be challenging and yes, at times exasperating. However, some derive great satisfaction from working together with these patients to improve their lives. These physicians are also aware of the critical importance of psychogastroenterology, which is why this excellent compendium edited by Drs. Knowles, Keefer, and Mikocka-Walus is essential reading for mental health professionals, but also to all physicians who treat these patients, regardless of their specialization." - Professor Ami D. Sperber, MD, MSPH, AGAF; Professor Emeritus of Medicine; Member, Rome Foundation Board of Directors; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"There is increasing evidence of the importance of the brain-gut axis in gastrointestinal disease and gastrointestinal symptoms. Clinicians caring for persons with gastrointestinal disorders have increasingly recognized the responsibility they have to inquire as to patients’ mental health status and the need to incorporate mental health disease management in their overall treatment plans. Knowles, Keefer and Mikocka-Walus have recognized the need for greater discussion and management advice for mental health professionals in the field of gastrointestinal diseases as they are increasingly called upon to participate in the care of these patients. Knowles, Keefer and Mikocka-Walus have assembled a superb handbook with an acclaimed international roster of authors that meticulously reviews the management of mental health disorders in gastrointestinal diseases." - Professor Charles N Bernstein, MD, FRCPC; Distinguished Professor of Medicine; Director, University of Manitoba IBD Clinical and Research Centre; Bingham Chair in Gastroenterology, Winnipeg, Canada"I highly recommend this ground-breaking and comprehensive practical guide to psychogastroenterology to any mental health professional treating adults with gastrointestinal health problems. It is an essential resource in this clinical domain, and one that is highly readable, amazingly broad in scope, and admirably grounded in current empirical knowledge. Filled with innumerable pearls of wisdom, illustrations, pragmatic tips, forms, reference tables, and handouts, this is not a book you will read once and then put aside, but rather one that you will want to keep within reach for guidance in your everyday clinical practice."- Professor Olafur S. Palsson, Psy.D.; Professor of Medicine, University of North Carolina at Chapel Hill, United States of America "This is a must-have go-to resource for health professionals providing psychological care for those with gastrointestinal illnesses. The medical background on GI conditions ranging from dyspepsia to IBD and colon cancer sets the stage for the evidence-based guidance on relevant psychological treatments. Practical and informative, the book is a superb entrance into the world of psychogastroenterology." - Professor Lesley Graff, PhD, CPsych; Professor & Head, Clinical Health Psychology Department, Max Rady College of Medicine University of Manitoba & Medical Director, Clinical Health Psychology Program Winnipeg Regional Health Authority Canada, Winnipeg, CanadaTable of ContentsForeword by William E. Whitehead; Part 1: Introduction to gastrointestinal physiology and conditions, the brain-gut axis, and working within health care teams; Chapter 1: The gastrointestinal tract: A brief introduction to healthy digestion by Dr Christopher F.D Li Wan Suen and Dr Peter De Cruz; Chapter 2: The upper gastrointestinal tract, common conditions and recommended treatments by Professor Geoff Hebbard; Chapter 3: The lower gastrointestinal tract, common conditions and recommended treatments by Dr Rebecca Burgell and Dr Bei Ye; Chapter 4: Gastroenterological cancers and stomas by Professor Timothy Pearman and Dr Elizabeth L. Addington; Chapter 5: Stress and the brain-gut axis across the spectrum of digestive disorders by Dr Gregory Sayuk; Chapter 6: Working with gastroenterologists, health administrators, and other members of the gastrointestinal and allied health care team by Dr Sarah W. Kinsinger; Part Two: Psychological concerns and conditions in gastroenterological cohorts; Chapter 7: Common gastrointestinal investigations and psychological concerns by Dr Tuan Duong and Professor Jane M. Andrews; Chapter 8: Common psychological issues in gastrointestinal conditions by Associate Professor Antonina Mikocka-Walus, Ms Catherine Emerson, Dr Lisa Olive and Dr Simon R. Knowles; Chapter 9: Working with complex patients with gastrointestinal and psychological concerns Dr Emily Edlynn and Dr Tiffany Taft; Part Three: Psychological, psychopharmacological, and eHealth approaches in psychogastroenterology; Chapter 10: Psychological assessment, formulation, and intervention planning in gastrointestinal cohorts with psychological issues by Dr Philip Keightley and Dr Simon R. Knowles; Chapter 11: Promoting change in psychological and gastrointestinal conditions - motivational interviewing (MI) by Dr Daron A. Watts, Dr Hans R Watson and Professor Terry L. Correll; Chapter 12: Promoting change in gastrointestinal conditions - Solution-Focused Brief Therapy (SFBT) by Assistant Professor Anne Lutz and Dr Christiaan van Woerden; Chapter 13: Stress management and mindfulness-based stress reduction (MBSR) approaches to gastrointestinal conditions by Anjali U Pandit and Dr Sarah Ballou; Chapter 14: Cognitive behavioural therapy (CBT) approaches to gastrointestinal conditions by Ms Karen J. Conlon and Associate Professor Laurie Keefer; Chapter 15: Hypnosis approaches to gastrointestinal conditions by Dr Megan E. Riehl; Chapter 16: Psychodynamic-interpersonal therapy (PIT) approaches to gastrointestinal conditions by Professor Elspeth Guthrie; Chapter 17: Emerging approaches - acceptance and commitment therapy (ACT) approaches to gastrointestinal conditions by Associate Professor Nuno Ferreira; Chapter 18: Behavioural approaches to managing substance-related problems in gastrointestinal conditions by Professor Eva Szigethy and Dr Trent Emerick; Chapter 19: Psychopharmacology in gastrointestinal cohorts by Ms Elspeth Carruthers and Dr Juilan Stern; Chapter 20: The role of eHealth in psychogastroenterology by Dr Andrew McCombie and Dr Simon R. Knowles; Part 4: Supervision and future challenges in psychogastroenterology; Chapter 21: Supervision and future challenges in psychogastroenterology by Dr Simon R Knowles, Associate Professor Laurie Keefer and Associate Professor Antonina Mikocka-Walus; References; Index

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Book SynopsisA riveting investigation of inflammation—the hidden force at the heart of modern disease—and how we can prevent, treat or even reverse it

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Book SynopsisAn essential resource for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists, and all those working in the field of hepatocellular carcinoma (HCC), Hepatocellular Carcinoma: A Practical Approach covers the updates and recent developments on the diagnosis, screening, and comprehensive medical and surgical management of HCC.This one-of-a-kind textbook explores all aspects of the disease using a practical, evidence-based approach, and provides step-by-step treatment guidelines that are applicable to all clinical scenarios.Highlights in the text include: screening and surveillance methods to aid in the prevention of HCC imaging technologies for accurate diagnosis, including ultrasound and PET treatment modalities for HCC, such as local ablation therapy, chemoembolization, chemotherapy, and liver resection and transplantation a discussion on novel therapies and fuTrade ReviewThis volume covers comprehensively recent developments on the diagnosis, screening and medical and surgical of HCC, and is essential reading for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists and other working in the field of HCC." - Anticancer research, April 2010 Table of ContentsEpidemiology, Pathogenesis, Surveillance, and Prevention: Epidemiology of the Hepatocellular Carcinoma. Molecular Pathogenesis. HCC Screening and Surveillance. Prevention of Hepatocellular Carcinoma. Diagnosis: Tumor Markers and Molecular Biology. Imaging of Hepatocellular Carcinoma. Staging. Management: Local Ablation Therapy. Chemotherapy and Novel Systemic Therapies. Chemoembolization, Radioembolization, and Other Novel Intra-arterial Therapies. Liver Resection. Liver Transplantation as Treatment for HCC.

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Book SynopsisAn easy-to-follow plan to regain a healthy gastrointestinal system-and relieve problems from gas to bloating to IBS. Close to 100 million Americans suffer from chronic-and sometimes very serious- gastrointestinal conditions. Prominent gastroenterologist Dr. Wesley Jones has found that virtually all digestive problems have one single underlying cause-constipation. Our modern diets and stressful lifestyles can make poor digestion such a common experience that sometimes people don't even recognize it as a problem. Here, Dr. Jones provides a proven program that has already helped thousands relieve and prevent constipation-related gastrointestinal problems for life. No one wants to talk about constipation, but millions suffer from it. Take as evidence the ubiquitous ads for Dannon's billion-dollar brand, Activia, which features Jamie Lee Curtis talking about occasional irregularity. Constipation is one of the most common gastrointestinal complaints in the United State

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Book Synopsis* Condensed, unified format for this very key topic. * Content tailored to the needs of the practicing clinician and the requirements of GI board examinations.Trade Review“This is an outstanding, succinct paperback text of the normal physiology of the digestive system written by an authoritative team of experts that is likely to become the standard reading for introductory courses to digestive system physiology. It is also a quick read for practicing gastroenterologists, surgeons, or internists who appreciate the value of understanding the cutting edge of physiologic principles of our field.” (Gastroenterology, 1 June 2015) Table of ContentsContributors, vi Preface, ix About the companion website, x 1 Structure and innervation of hollow viscera, 1Laura D. Wood & Elizabeth A. Montgomery 2 Gastrointestinal hormones in the regulation of gut function in health and disease, 15John Del Valle 3 Gastrointestinal motility, 33Ikuo Hirano & Darren Brenner 4 Gastrointestinal immunology and ecology, 46Shehzad Z. Sheikh & Scott E. Plevy 5 Gastric physiology, 58Mitchell L. Schubert 6 Structure and function of the exocrine pancreas, 78James H. Grendell 7 Absorption and secretion of fluid and electrolytes, 92Lawrence R. Schiller 8 Absorption of nutrients, 108Lawrence R. Schiller 9 Hepatic structure and function, 129Michelle T. Long & Lawrence S. Friedman 10 The splanchnic circulation, 149Peter R. Kvietys & D. Neil Granger 11 Composition and circulation of the bile, 164Allan W. Wolkoff 12 Bilirubin metabolism, 173Allan W. Wolkoff Index, 183

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Book SynopsisTurbocharge your gut health with this bold new plant-based plan.

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Book Synopsis

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Book SynopsisWritten by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.Table of ContentsGenetic Susceptibility to Colorectal Cancer. Epidemiology of Colorectal Cancer. Colorectal Cancer Screening. Pathology. Familial Cancer Management. The Surgical Principles of Managing Colorectal Cancer. Adjuvant Therapy for Colorectal Cancer. The Role of Radiotherapy in the Treatment of Rectal Cancer. Hepatic Directed Therapy. Pharmacogenomics of Colorectal Cancer. Drug Development for Advanced Colorectal Cancer in the U.S.

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Book SynopsisColorectal cancer is the second-leading cause of cancer-related death in the Western World. This Second Edition analyzes the genetics, mechanisms, and development of colorectal carcinoma and supplies the latest research and recommendations on the detection, treatment, and prevention of malignancies of the colon, rectum, and anus.Table of ContentsBenign Neoplasms of the Colon and Rectum. Large Bowel Carcinoma: Screening, Surveillance, and Follow-up. Malignant Neoplasms of the Colon. Malignant Neoplasms of the Rectum. Perianal and Anal Canal Neoplasms. Anal and Transanal Techniques. Laparoscopic Colon and Rectal Surgery.

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Book SynopsisProviding an essential brainstem relay for three cranial nerves, the NST coordinates highly complex sensory information. While other functions of the NST have received attention, its role in gustatory processing has received little. The first reference devoted exclusively to gustatory processing, The Role of the Nucleus of the Solitary Tract in Gustatory Processing offers an in-depth review of one of the most important central relay stations in the brain.Combining widely dispersed research into a comprehensive single volume, it presents a thorough historical background, documents the anatomy of the rostral nucleus of the solitary tract (rNST), and explores the properties of synaptic transmitters and neurons within that tract. The book examines the role of reflex activities and considers factors that influence how gustatory rNST neurons respond to taste stimuli. It describes the development and maturational changes the rNST undergoes and considers the challenge involved with identifying rNST neural circuits.The Role of the Nucleus of the Solitary Tract in Gustatory Processing brings together expert investigators who have contributed substantially to the current knowledge of the anatomy, physiology, and developmental biology of the solitary nucleus. This pertinent work serves as a standard reference for those involved in the field, providing ready access to past investigations and inviting practitioners to create new approaches that will advance knowledge about the central processing of gustatory information.Table of ContentsHistorical Perspectives. Anatomy of the Rostral Nucleus of the Solitary Tract. Neurotransmitters and Receptors Expressed by rNST Neurons. Reflex Connections. Neural Coding in the Rnst. Development and Plasticity of the Gustatory Portion of Nucleus of the Solitary Tract. rNST Circuits.

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Book SynopsisThis volume presents information regarding the mechanisms of protein absorption under normal and pathologic conditions, in addition to reviewing changes that occur at various stages of life. General modifiers of intestinal absorption, such as the processing of foods, the nutritional status of the individual, and disease, are explored with reference to both proteins and minerals. Inorganic macronutrients, namely calcium, magnesium and phosphorus, are discussed in relation to protein ingestion. The book also explores the concept of essential trace elements (e.g., iron, zinc, copper, and iodine) and their link to protein sufficiency. The relationship of ultratrace elements with the content of proteins in food is examined, and the book offers a fresh view of the role of certain elements, particularly zinc, on the conformation of proteins linked to DNA, hormone receptors, and gene products. Protein Nutrition and Mineral Absorption is packed with 2,300 references, 100 figures and graphs, pluTrade Review"This is a wonderful volume. It will be of great use to all of us involved in clinical nutrition and will serve as an excellent starting point for anyone wishing an introduction to this important field."-Journal of Parenteral and Enteral NutritionTable of ContentsMECHANISMS OF PROTEIN ABSORPTION. HISTORICAL PERSPECTIVE. AMINO ACID VS. OLIGOPEPTIDE ABSORPTION. SMALL PEPTIDES AS THE MAJOR SUBSTRATES OF PROTEIN ABSORPTION. ABSORPTION OF INTACT PROTEINS. REFERENCES. EFFECT OF NUTRITIONAL STATUS AND DISEASE ON PROTEIN ABSORPTION. INTRODUCTION. EFFECT OF PROTEIN DEFICIENCY ON AMINO ACID AND OLIGOPEPTIDE ABSORPTION. DIETARY AND METABOLIC REGULATION OF AMINO ACID ABSORPTION. ABSORPTION OF INTACT PROTEINS IN NUTRITIONAL DEPRIVATION. EFFECT OF MATERNAL PROTEIN RESTRICTION ON NEONATAL PROTEIN ABSORPTION. ABSORPTION OF PROTEIN IN ACQUIRED DISEASE. General Considerations. Celiac Disease (Sprue). Renal Disease. ABSORPTION OF PROTEIN IN CONGENITAL DISEASE. General Considerations. Cystinuria. Familial Protein Intolerance. Hyperdibasic Aminoaciduria. Neutral Amino Acid Malabsorption Syndromes. Iminoglycinuria. Lowe's Syndrome. Congenital Agammaglobulinemia. Peptiduria Associated with Aminopeptidase-P Deficiency. REFERENCES. DEVELOPMENTAL FACTORS IN PROTEIN AND MINERAL ABSORPTION. INTRODUCTION. ONTOGENY OF THE GASTROINTESTINAL TRACT. Morphology. Development of the Gastrointestinal Mucosal Barrier. Membrane Composition and Rheologic Properties. DEVELOPMENT OF PROTEIN ABSORPTION MECHANISMS. Enzymatic Ontogeny. The Mammalian Intestine. Ontogeny of Human Protein Absorptive Mechanisms. Ontogeny of Amino Acid and Dipeptide Absorptive Mechanisms. Hormonal Control of Enzymatic Maturation. Role of Diet in the Development of Intestinal Absorptive Function. ONTOGENY OF MINERAL ABSORPTION. General Considerations. Calcium, Magnesium, Phosphorus. Iron. Zinc and Copper. Other Elements. PROTEIN AND MINERAL ABSORPTION LATE IN LIFE. Protein. Minerals. REFERENCES. EFFECT OF FOOD SOURCES AND PROCESSING ON PROTEIN AND MINERAL ABSORPTION. GENERAL. IMPORTANCE OF FOOD SOURCES. PHYSICAL TREATMENTS. Milling, Polishing, and Other Mechanical Processes. Heating. Cooking. Dehydration. Water Extraction. Leaching. Washing. Freezing/Thawing. Osmotic Alteration. Storage (Aging). Packaging. Emulsification, Homogenization, Gellification. CHEMICAL TREATMENTS. Oxidation, Reduction. Schiff Base Formation. Maillard Reactions. Browning. Acidification. Alkalinization. Sequestration. Natural Chelating Agents. Chemical Processing with Macro-Additives: Salt, Curing. REFERENCES. CALCIUM, MAGNESIUM, AND PHOSPHORUS ABSORPTION, NUTRITIONAL STATUS AND EFFECT OF PROTEINS. NUTRITIONAL ASPECTS OF CALCIUM ABSORPTION. Calcium in Foods and Its Bioavailability. Mucosal Receptors at the Brush Border Mucosa. Transcellular Transport of Calcium. Effects of Protein Nutrition on Calcium Metabolic Balance. Protein-Calcium-Phosphorus Interactions. Osteoporosis. Overview of Calcium-Protein-Phosphate Interactions. NUTRITIONAL ASPECTS AND MECHANISMS OF MAGNESIUM ABSORPTION. Magnesium Requirements and Absorption. Protein-Energy Malnutrition and Magnesium Sufficiency. Studies Relating Protein and Magnesium Absorption and Sufficiency. Magnesium and Calcium Imbalances in Metabolic Disease. PHOSPHATE ABSORPTION, CATION BALANCE REGULATION, AND PROTEIN INTAKE. Dietary Phosphate and Intestinal Absorptive Mechanisms. The Phosphate-Calcium-Protein Connection. REFERENCES. NUTRITIONAL FACTORS, PROTEINS, AND THE ABSORPTION OF IRON AND COBALT. IRON CHEMISTRY AND DETERMINANTS OF THE SOLUBILITY OF THE ELEMENT. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF IRON. Luminal Factors. Mucosal Factors. Corporeal Factors. PROTEIN DERIVED PRODUCTS AND IRON ABSORPTION. Historical Background. Animal Proteins. Amino Acids. Peptides. PROTEIN NUTRITIONAL STATUS AND INTERACTIONS WITH IRON ABSORPTION. DEFECTS IN THE INTESTINAL ABSORPTION OF IRON. Idiopathic Hemochromatosis. Iron Malabsorption. PROTEIN AND NUTRITIONAL FACTORS IN THE ABSORPTION OF COBALT. Cobalt as a Possible Essential Trace Element. Essentiality of Cobalt and Cobalamines. Absorption of Vitamin B12 and of Cobalt. Attempts at Pharmacologic Uses of Cobalt. Toxicity of Cobalt. REFERENCES. ZINC ABSORPTION AND SUFFICIENCY AS AFFECTED BY PROTEIN AND OTHER NUTRIENTS. SIGNIFICANCE OF ZINC AS AN ESSENTIAL NUTRIENT. Requirements of Zinc by Vegetables and in the Animal Kingdom. Role of Zinc in Biological Processes. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF ZINC. Luminal and Dietary Factors. Mucosal Factors. Corporeal Factors. PROTEIN-DERIVED PRODUCTS AND ZINC ABSORPTION. Introduction. Amino Acids. Peptides. Proteins. ZINC MALABSORPTION. Congenital Conditions. Acquired Malabsorption. REFERENCES. COPPER ABSORPTION AND BODY DISTRIBUTION: ROLE OF PROTEIN AND OTHER NUTRIENTS. ROLE OF COPPER IN BIOLOGICAL SYSTEMS. Biological Roles of Copper. MECHANISMS FOR THE LUMINAL REMOVAL OF COPPER AND TISSUE DISTRIBUTION. Transport Across Membranes. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF COPPER. Ecological and Geographical Considerations. Luminal Factors. Mucosal Factors. Somatic Factors. PROTEIN-DERIVED PRODUCTS AND COPPER ABSORPTION. Amino Acid Participation in Copper Transport Mechanisms. Effect of Proteins and Protein Breakdown Products. INTERACTION OF OTHER ELEMENTS ON COPPER ABSORPTION. Inhibition of Copper Absorption by Zinc. Copper-Zinc Imbalance, Cholesterol, and Chronic Degenerative Diseases. GENETIC DISEASES OF COPPER ABSORPTION AND HOMEOSTASIS. Defects in Copper Uptake, Distribution, and Excretion. REFERENCES. NUTRITIONAL, ENVIRONMENTAL, AND PHYSIOLOGIC FACTORS AFFECTING SELENIUM, CHROMIUM, AND NICKEL SUFFICIENCY. SELENIUM. Selenium as a Nutrient and as a Potential Toxic Agent. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF SELENIUM. SELENIUM ADSORPTION FROM HIGH PORTEIN PRODUCTS. CHROMIUM. Chromium Chemistry and the Evidence of Nutritional Essentiality. Chromium Absorption and Tissue Distribution. Biological Roles of Chromium. Chromium Nutrition in Protein-Energy Malnutrition, Stress, and TPN. NICKEL. REFERENCES. NUTRITIONAL STATUS AND THE EFFECT OF PROTEIN AND OTHER FOODSTUFFS ON THE ABSORPTION OF MANGANESE, MOLYBDENUM, AND VANADIUM. MANGANESE. Role of Manganese in Biological Processes. Nutritional Requirements in Man and Animals. Manganese Deficiency and Toxicity. Factors Involved in the Intestinal Absorption of Manganese. Protein-Derived Products and Manganese Absorption. MOLYBDENUM. Occurrence of Molybdenum in Nature. Its Passage Through the Food Chain. Role of Molybdenum in Biological Processes. Nutritional Requirements in Man and Animals. Molybdenum Deficiency and Toxicity. Factors Involved in the Intestinal Absorption of Molybdenum. Protein-Derived Products and Molybdenum Absorption. VANADIUM. Role of Vanadium in Biological Processes. Intestinal Absorption of Vanadium. REFERENCES. THE ABSORPTION OF ARSENIC, BORON, SILICON, ALUMINUM, TIN, IODINE, AND FLUORINE: INTERACTIONS WITH PROTEINS AND OTHER NUTRIENTS. NUTRIENT VARIABLES AND THE ABSORPTION OF ARSENIC. Man and Its Relationship with Arsenic. Presentation of the Element in Nature. Arsenic as an Essential Trace Element. Role of Arsenic in Biological Processes. Arsenic in the Food Chain. Absorption of Arsenic. Metabolism of Protein and Amino Acids and Arsenic Nutrition. BIOLOGICAL AND NUTRITIONAL FACTORS IN BORON SUFFICIENCY. Boron in Nature and Its Role in Biological Processes. Boron in the Food Chain and Metabolic Fate of Ingested Boron. Metabolic Effects of Boron. Interaction with Vitamin D and Other Minerals. Role of Certain Amino Acids. SILICON AS A NUTRIENT. INTERACTIONS WITH PROTEINS AND OTHER DIETARY PRODUCTS. Silicon in Nature and in the Human Food Chain. Biological Role of Silicon. Interaction of Silicon with Other Nutrients. NUTRITIONAL AND TOXIC ASPECTS OF ALUMINUM IN THE DIET AND THE ENVIRONMENT. Aluminum in Nature and in the Food Chain. Intestinal Absorption of Aluminum. Toxicity of Aluminum. Factors Affecting the Oral Absorption of Aluminum. TIN IN THE DIET AND THE ENVIRONMENT. ITS INTERACTION WITH OTHER NUTRIENTS. Tin in Nature and in the Food Chain. The Question of Tin Essentiality. Intestinal Absorption of Tin. Interaction of Tin with Other Nutrients. PROTEIN AND OTHER NUTRITIONAL FACTORS IN THE METABOLISM AND ABSORPTION OF IODINE. Iodine in Nature. Chemical Characteristics. Role and Metabolism of Iodine. Essentiality of Iodine. Requirements. Nutritional Deficit and Toxicity. Iodine in Foods. Relation with Nutritional Status and Protein Sufficiency. NUTRITIONAL FACTORS IN THE ABSORPTION OF FLUORINE. Role of Fluorine Compounds in Calcified Tissue and Dental Integrity. Possible Essentiality of Fluorine. Metabolic Effects. Fluorine in the Diet. Absorption and Excretion. Relationship of Fluorine with Macronutrients. Interactions with Other Minerals. REFERENCES. "FINGERS", "KNUCKLES", "HANDS", "FISTS", "SIGNATURES", AND OTHER STRUCTURAL MOTIFS IN PROTEINS INVOLVING ZINC AND OTHER ESSENTIAL ELEMENTS. ZINC "FINGERS" AND THEIR ROLE IN BIOLOGICALLY ACTIVE PROTEINS. Transcription Factors. Zinc Fingers in Hormone Receptors. Finger Loops and Oncogenes. BINDING OF ZINC TO OTHER PROTEINS. DEVELOPMENT OF CATALYTIC PROPERTIES. DIFFERENT "SIGNATURES". COPPER "FISTS", METALLOTHIONEINS, AND GENE EXPRESSION. PROTEIN STRUCTURE DESIGN: "HELICES", "HANDS", "GREEK KEYS", "b-BARRELS", "SHEETS", "COILS", AND "ZIPPERS". REFERENCES. OVERVIEW.

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Book SynopsisThis important new book presents critical information on the clinical and morphological aspects of various endocrinological disorders of the gut and pancreas. Topics include a historical perspective and broad overview of the neuroendocrine component of the gut; hyperplastic proliferations of gastrointestinal endocrine cells; pancreatic endocrine cells and their non-neoplastic proliferations; tumors and lesions; and endocrine differentiation in nonendocrine tumors. The book stresses clinical and pathological aspects of these topics, as well as the pathogenesis, clinicopathological correlations, and diagnostic approaches. Gastroenterologists, pathologists, internists, surgeons, endocrinologists and others interested in endocrinological disorders of the gut and pancreas will discover that this book will be a welcome addition to your reference library.Table of ContentsNeuroendocrine Cells of GEPH Axis: Introduction and Historical Perspectives. Hyperplastic Proliferations of the Gastrointestinal Endocrine Cells. Pancreatic Endocrine Cells and Their Non-Neoplastic Proliferations. Clinically-Non-Functioning Pancreatic Endocrine Tumors. Serotonin-Producing Tumors and the Carcinoid Syndrome. Gastrin-Producing Tumors and the Z-E Syndrome. Insulin-Producing Tumors and the Insulinoma Syndrome. Glucagon-Producing Tumors and the Glucagonoma Syndrome. Somatostatin-Producing Tumors and the Somatostatinoma Syndrome. PP-Producing Tumors. The MEN Syndromes. Hormonally Active Non-Endocrine Tumors.

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Book SynopsisThe latest data on the pathogenesis of ulcer disease is presented in this text, with the emphasis that an understanding of the pathogenesis and etiology of ulcer diseases represents the most rational approach to pharmacology - the prevention and treatment of ulcer disease. Early and late biochemical and functional changes, morphologic stages of the injury and healing phases, as well as vascular factors in ulceration are highlighted. In addition, new pathogenetic elements on neuroendocrine and other endogenous modulators and circadian rhythms in ulcerogenesis are covered. The section on new pharmacology consists of several chapters presenting new animal models of gastric, small intestinal and colonic ulcers because in vivo models represent the basis to test and accurately detect new antiulcer drugs. A large series of chapters cover new drugs for ulcer prevention and treatment. This book is indispensible to investigators in basic and applied research, academic and industrial pharmacTable of ContentsPATHOGENESIS. EARLY AND LATE BIOCHEMICAL AND FUNCTIONAL CHANGES. Mechanisms of Gastrointestinal Damage by Non-Steroidal Anti-inflammatory Drugs. Correlations Between Free Radicals and Membrane-Dependent Energy Systems in Ethanol-Induced Gastric Mucosal Damage in Rats. Gastric Motility and Overall Blood Flow During Cold Restraint in the Rat. Enzymic Aspects of Cysteamine-Induced Duodenal Ulcers with Special Reference to Bicarbonate Secretion. Cysteamine is a Potent Inhibitor of Duodenal Phosphoprotein Phosphatase in Rats: Probable Role of Gastric Acid Hypersecretion. MORPHOLOGIC STAGES OF THE INJURY AND HEALING PHASES. Mechanisms of Rapid Epithelial Restitution of the Superficial Rat Gastric Mucosa after Ethanol Injury. Microscopic Analysis of Ischemic Gastric Injury in the Rat. Effects of Ulcerogens and Other Conditions on Gastric Epithelial Proliferation. Gastric Mucosal Barriers and the Actions of Aspirin. Early Cytologic Precursors to Cysteamine-Induced Duodenal Ulcer in Rats. VASCULAR FACTORS IN ULCERATION. Vascular Factors in Gastric Mucosal Injury. The Role of Microvasculature in Acute Gastric Mucosal Damage and Protection. Gastric Mucosal Microvascular Architecture and Mucosal Blood Flow in Rats During Stress. Role of Acid and Tissue Prostaglandins in the Production of Gastric Mucosal Damage. Critical Mucosal Oxygenation Level and Promotion by Acid and Histamine of Hemorrhagic Shock-Induced Gastric Ulcer in Rats. CENTRAL AND PERIPHERAL NEUROENDOCRINE INFLUENCES. Central Nervous System Action of Neuropeptides to Influence or Prevent Experimental Gastroduodenal Ulceration. Neural Influences on Gastroduodenal HCO3 Secretion. Involvement of Dopamine and Dopamine Receptors in Stress Gastric Ulceration. Somatostatin and Gastrin Secretion from the Isolated Perfused Rat Stomach: Neural and Hormonal Regulation and the Effect of the Ulcerogen, Cysteamine. Possible Involvement of Central Mechanisms in Antiulcer and Antisecretory Actions of Prostaglandins. CIRCADIAN RHYT

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Book SynopsisThis book evolved from a two-day 1993 International Symposium on Radiation and the Gastrointestinal Tract held at the Uniformed Services University of the Health Sciences, Bethesda, Maryland. This area of investigation is particularly important because of growing medical needs and the documented occurrence of accidents involving overexposure of healthy subjects/patients. Some questions have been answered through cellular and animal research-results that lead to hypotheses that have been tested through clinical protocols. In an attempt to answer the unresolved questions, basic scientists and clinicians describe the data obtained to date, present in a critical manner the consensus that has been reached, and discuss what still remains to be investigated.The book is divided into five parts: Overview and Clinical Perspective, Emesis, Motility, Diarrhea, and Behavioral Correlates of Gastrointestinal Dysfunction. Each part consists of separate discussions on the pathophysiology, the methodology, and, when applicable, the clinical relevance of the observations.The book provides helpful information to both basic scientists involved in radiobiological research and to clinicians caring for patients exposed to radiation. It also serves as an introduction to the subject for young clinical investigators interested in the field and for scientists searching for correlates between their observations and disorders of the gastrointestinal tract.Table of ContentsOverview and Clinical PerspectiveClinical Aspects of Irradiation-Induced Alimentary Tract Injury, T.R. SpitzerEmesisRadiation-Induced Emesis in Animal Models, G.L. KingDifferences in Anti-Emetic Predictability amongst 5-HT, Receptor Antagonist Drugs, P.R. BlowerClinical Trials with Ondansetron in Radiation-Induced Emesis, J.C. BrysonMotilityRadiation-Induced Gastric Dysfunction, A. DuboisPostirradiation Alterations in Small and Large Bowel Motility, M.F. Otterson and R.W. SummersNitric Oxide and Smooth Muscle Relaxation in the Intestine. Chemical and Radiation Effects Measured by EPR/SPIN Trapping, L. Steel-Goodwin and A.J. CarmichaelNeurochemical Changes in the Irradiated Brain-Gut Axis, S.B. KandasamyDiarrheaRadiation-Induced Changes to Epithelial and Non-Epithelial Tissue, K.E. Carr, S.P. Hume, R. Ettarh, E.A. Carr, and J.S. McCulloughMolecular Mechanisms of Cellular Radioresistance and Radiosensitivity, K.F. Pirollo, X. Lin, Z.M. Hao, Z. Villegas, and E.H. ChangThe Effect of Radiation on Intestinal Electrolyte Transport, P.J. Gunter-SmithNearby Shielding Influences Survival of the Irradiated Intestine, R.M. VigneulleModification of Radiation Injury to the Intestine by Eicosanoids and Thiol Radioprotectors, W.R. HansonEffect of Radioprotective Agents on Survival after Acute Intestinal Radiation Injury, J.F. Weiss, M.R. Landauer, P.J. Gunter-Smith, and W.R. HansonNutritional Support of Irradiated Intestine, V. Srinivasan and A. DuboisChemotherapy and Radiation Protection with Amifostine: Clinical Studies, E.P. Mitchell, R.D. Reynolds, D. Graden, and R.L. CapizziGastrointestinal Syndrome after Accidental Overexposure during Radiotherapy, D.F. Flynn, I. Mihalakis, T. Mauceri, and M.R. PinsBehavioral Correlates of GI DysfunctionEffects of Different Types of Radiation on Emesis and Taste Aversion Learning, B.M. Rabin and G.L. KingBehavioral Assessment of Antiemetic Drugs in Rat

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Book SynopsisMolecular and Cell Biology of the Liver features the latest research findings regarding liver structure and function. A unique feature of the book is the brief science reviews that are included in each chapter which provide essential background information to allow readers to better grasp the subject matter within a chapter. The book covers liver biology from the molecular level to groups of liver cells and explains how groups of hepatocytes interact in similar microenvironments. Other important cell types found in the liver are also examined. Illustrations ranging from electron micrographs to fully rendered drawings act as visual aids to help readers understand complex structural-functional interactions. Molecular and Cell Biology of the Liver will benefit hepatologists, gastroenterologists, cell biologists, anatomists, toxicologists, and other researchers interested in liver structure and function.Table of ContentsMolecular Aspects: Gene Activity and Regulation (G. Schreiber and A.R. Aldred). Proteins and Plasma Protein Metabolism (T. Peters, Jr.). Carbohydrates and Glycogen Metabolism (R.R. Cardell and E.L.S. Cardell). Subcellular Components: The Plasma Membrane and Intercellular Junctions (W. Hong). Receptors and Endocytosis (C.A. Casey and D.J. Tuma). Cytoskeleton (S.W. French, M. Cadrin, H. Kawahara, and K. Kachi). Peroxisomes and Lysosomes (U. Soto, S. Rapp, K. Gorgas,and W.W. Just). Parenchymal Cells: Fetal and Postnatal Growth (J. Vassy and M. Kraemer). Regeneration (A. Francavilla, T.E. Starzl, D.H. Van Thiel, M. Barone, and L. Polimeno). Functional Compartmentation of Hepotocytes (C.M. Berkowitz, E. Guibert, B. Bilir, and J.J. Gumucio). Extracellular Matrix (M. Dziadek and T. Thomas). Nonparenchymal Cells: Endothelial Cells and Kupffer Cells (R.S. McCuskey). Fat-Storing Cells (H.F.J. Hendricks, A. Brouwer,and D.L. Knook). Pit Cells (L. Bouwens). Bile Duct Cells (P. Van Eyken and V.J. Desmet).

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book SynopsisIn this greatly expanded edition of his international bestseller, Andreas Moritz reveals the most common but rarely recognized cause of illness - gallstones congesting the bile ducts in the liver. Besides leading to gallbladder diseases and gallstone attacks in at least 20 million Americans each year, in many cases, liver bile duct congestion sets the stage for even more serious, seemingly unrelated, conditions, including obesity, diabetes, heart disease, and cancer. Most adults living in the industrialized world, and especially those suffering a chronic illness, such as irritable bowel syndrome, heart disease, arthritis, multiple sclerosis, cancer, or diabetes, have in fact hundreds if not thousands of gallstones (mainly clumps of hardened bile that escape detection for they are invisible to x-rays, ultrasound, and CT scans) blocking the bile ducts of their liver. This book provides a thorough understanding of the liver and its complex functions, what causes gallstones in the liver and gallbladder, and why these stones can be held responsible for the most common diseases so prevalent in the world today. It provides the reader with the knowledge needed to recognize these stones and gives the necessary, do-it-yourself instructions to painlessly remove them in the comfort of one''s home. Packed with images, the book also gives practical guidelines on how to prevent new gallstones in both the liver and gallbladder. The liver and gallbladder flush (cleanse) has led to extraordinary improvements in health and wellness among millions of people who have already given themselves the precious gift of a strong, clean, revitalized liver. Besides providing the practical procedures to cleanse the liver, gallbladder, kidneys, and intestines, Moritz explains in great detail the origin of all types of common diseases and how to prevent or reverse them naturally. The book is packed with precious, time-tested approaches designed to return the body to a permanent state of balance and vitality; it includes a complete program of healthcare, which is primarily based on the ancient medical system of Ayurveda and the vast amount of experience Andreas Moritz has gained in the field of health restoration during the past 30 years. Moritz is the author of 15 groundbreaking books on natural health and a leading, internationally recognized, authority in the field of integrative medicine.

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Book SynopsisA clinically tested treatment protocol for Functional Abdominal Pain in young children. Using the Feelings and Body Investigators (FBI), this playful handbook empowers children and families to be detectives who investigate the wisdom of the body probing different types of pain, emotions, and all the body's cryptic messages.Trade Review'Dr. Zucker's beautifully written and creatively illustrated book Treating Functional Abdominal Pain in Children fills a big gap in our knowledge of and provides therapeutic tools for children suffering from these common chronic disorders. The innovative and validated treatment approaches as developed by Dr. Zucker over more than a decade of working with such patients, explained in practical detail proposed by her and her co-authors, are a welcome and much needed addition to the field. I cannot think of any publication in this field of medicine that is as informative, entertaining and filled with actionable strategies for young patients suffering from chronic abdominal pain. Parents, patients and physicians will love this book!' Emeran A. Mayer, M.D., Distinguished Research Professor, Departments of Medicine, Physiology and Psychiatry, David Geffen School of Medicine; Executive Director, G. Oppenheimer Center for Neurobiology of Stress and Resilience, Co-director, CURE: Digestive Diseases Research Center, UCLATable of ContentsPart I. The Background Science and Behind Feeling and Body Investigators: 1. Becoming a feeling and body investigator – pain division; 2. Visceral sensitivity as a superpower; 3. Responsive parenting and creating safety; 4. Discriminating safe from threatening body sensations: the science of interoceptive exposures; 5. The medical evaluation of abdominal pain in children, one general pediatrician's approach; Part II. A Session by Session Guide to Feeling and Body Investigators: 6. Initiation into feeling and body investigators; 7. The eats; 8. The explosions; 9. The zoomies and shakies Part I; 10. The Blahs; 11. The ouchies; 12. Session 7: The drowsies; 13. Session 8: The zoomies and shakies Part 2; 14. Session 9: the soothies; 15. FBI-Pain division chapter 15: session 10, the celebration…and the next leg of our journey..; Part III. Sample Workbook Pages, Handouts, and Additional Resources for Feeling and Body Investigators: Appendix 1; Appendix 2; Appendix 3.

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Book SynopsisAn informative and enjoyable book introducing gastrostomy tubes to children and their families, providing comfort, hope, and key information. Featuring easy to understand language, fun color illustrations and helpful instructions, this book is part of the innovative series The Strength of My Scars by surgeon, Maria Baimas-George.Table of ContentsG-Tubes – Fuel Me Up.

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Book SynopsisBringing together international experts in psychological and behavioural treatments for pediatric gastrointestinal symptoms, this book provides detailed, evidence-based protocols targeting gastrointestinal distress and associated mental health concerns for patients and their families. The first consolidated resource on the topic, Pediatric Psychogastroenterology gives mental health professionals access to the most up to date clinical knowledge and practice. Taking a holistic approach, it guides the reader on the treatment and care of pediatric gastrointestinal patients, as well as how to work with and support children's parents and families. The book is structured around symptom presentation and common challenges, enabling the reader to focus quickly on the area of need. Each chapter includes clinical pearls of wisdom and 62 developmentally appropriate worksheets for patients and their families to facilitate treatment, available for download.This pTrade Review‘The current book is the first to provide comprehensive information needed for any mental health professional entering the field or established providers looking for an update on recent practices and approaches. This book is a pleasure to read and will be an invaluable resource for any mental health care provider encountering youth with GI issues.’ Professor Carlo Di Lorenzo, Nationwide Children's Hospital, The Ohio State University, USA.‘Van Tilburg, Reed and Knowles have assembled an all-star cast that will make this book pivotal to current clinical care of disorders of gut-brain interaction in both health and disease and provide the basis for future research in the field!’ Professor Benjamin D. Gold, Children’s Healthcare of Atlanta Site for Improve Care Now (ICN), Past President, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN), USA. ‘What has become clear is the importance of the relationship between pediatric gastroenterologists and psychologists who collaborate on the care of so many patients. But, for that to happen seamlessly, they need to speak the same language and share a common knowledge base. This book will become the standard road atlas for that communication. It so nicely facilitates a mutual understanding of the complexities of the patients we share. Psychogastroenterology is a tour de force that will quickly become required reading.’ Professor Jeffrey S. Hyams, Connecticut Children’s Medical Center, University of Connecticut School of Medicine, USA. ‘This is a must-have practical and essential resource for health professionals providing care to children with gastrointestinal (GI) conditions.’ Professor Tonya M. Palermo, Seattle Children's Research Institute, University of Washington, USA. Table of ContentsPart 1: Introduction to pediatric gastrointestinal physiology and conditions, the brain-gut axis, and working within health care teams 1. Gastrointestinal anatomy and physiology 2. Stress, psychological factors, and the brain-gut axis 3. Common gastrointestinal conditions in pediatrics 4. Medical procedures/testing in pediatric gastroenterology 5. Helping youth manage medical procedures 6. Case conceptualization and assessment 7. Collaborative, multidisciplinary treatment 8. Working with parents and primary caregivers 9. Caring for youth and families with complex medical and psychosocial concerns Part 2: Psychological approaches in pediatric Psychogastroenterology 10. Feeding difficulties: Introduction 11. Feeding difficulties: Food refusal 12. Feeding difficulties: Food selectivity 13. Feeding difficulties: Difficulty swallowing and the fear of aversive consequences 14. Nausea and vomiting 15. Pain disorders: Introduction, assessment, and psychophysiology 16. Pain disorders interventions: Cognitive behavior therapy & Acceptance and commitment therapy 17. Pain disorder interventions: Hypnotherapy 18. Constipation and soiling: Infant/toddler 19. Constipation and soiling: Children and adolescents Part 3: Transition and future challenges in pediatric Psychogastroenterology 20. Chronic illness adjustment and transition 21. Supervision and future challenges in pediatric psychogastroenterology

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Book SynopsisSurvival of patients with metastatic cancer has increased over the past two decades as a result of a progressive improvement of regional and systemic therapies. However, oncologists' estimates of patients' predicted overall survival in metastatic cancer are imprecise. The purpose of this book is to systematize the evidence regarding the prognostic factors of metastatic gastrointestinal tumors, separating the findings with the highest level of evidence among those available for each disease by selecting studies with the highest scientific evidence level.

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Book SynopsisGastrointestinal Emergencies 3E provides practical, up-to-date guidance for gastroenterologists, endoscopists, surgeons, emergency and acute physicians, medical students and trainees managing patients presenting with GI complications and/or emergencies. Combining a symptom section, a specific conditions section and a section that examines complications (and solutions) of GI procedures, focus throughout is on clear, specific how-to guidance, for use before a procedure or immediately after emergency stabilization. An evidence-based approach to presentation, diagnosis and investigation is utilized throughout. New to this third edition are severalbrand new chapters covering various complications of procedures and specific conditions not previously featured, as well as a thorough look at the many diagnostic and therapeutic advances in recentyears. In addition, every chapter from the current edition has undergone wholesale revision to ensure it is updated with the very latesTable of ContentsNotes on contributors, vii Section 1: Approach to specific presentations 1 Approach to dysphagia, 3John S. A. Collins 2 Approach to vomiting, 8Bee Chan Lee and John S. A. Collins 3 Approach to upper gastrointestinal bleeding, 12Patrick B. Allen and Tony C. K. Tham 4 Approach to acute abdominal pain, 19Tony C. K. Tham 5 Approach to jaundice, 25Tony C. K. Tham 6 Acute severe lower gastrointestinal hemorrhage, 34Jennifer M. Kolb and Tonya Kaltenbach 7 Approach to diarrhea, 39John S. A. Collins Section 2: Complications of gastrointestinal procedures and therapy 8 Complications of upper gastrointestinal endoscopy, 45Daniel J. Stein and Reza Shaker 9 Complications of percutaneous endoscopic gastrostomy, 51Barbara Willandt and Jo Vandervoort 10 Complications of endoscopic variceal ligation, sclerotherapy, and balloon tamponade, 57Aarti K. Rao and Roy Soetikno 11 ERCP complications, 61Constantinos P. Anastassiades and Richard C. K. Wong 12 Complications of laparoscopic surgery, 70Stephen Attwood and Khalid Osman 13 Complications of liver biopsy, 77Robert J. Wong and Aijaz Ahmed 14 Complications of colonoscopy, 81Matthias Steverlynck and Jo Vandervoort 15 Complications of capsule endoscopy, 86Roy Soetikno and Andres Sanchez]Yague 16 Complications of endoscopic ultrasound, 91Maria Cecilia M. Sison]Oh, Andres Sanchez]Yague, and Roy Soetikno 17 Complications of Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD), 99Ichiro Oda, Haruhisa Suzuki, and Seiichiro Abe 18 Complications of bariatric surgery, 105Allison R. Schulman, Michele B. Ryan, and Christopher C. Thompson 19 Complications of drugs used in gastroenterology, 117Paul Kevin Hamilton and Philip Toner Section 3: Specific conditions 20 Foreign body impaction in the esophagus, 135George Triadafilopoulos 21 Esophageal perforation, 142Ioannis S. Papanikolaou and Peter D. Siersema 22 Acute upper non]variceal gastrointestinal hemorrhage, 151Kelvin Palmer 23 Acute pancreatitis, 158David R. Lichtenstein 24 Biliary tract emergencies, 172Joseph K. N. Kim and David L. Carr]Locke 25 Variceal hemorrhage, 177Roy Soetikno and Andres Sanchez]Yague 26 Acute liver failure, 183Philip S. J. Hall and W. Johnny Cash 27 Ascites and spontaneous bacterial peritonitis, 193Andrés Cárdenas, Isabel Graupera, and Pere Ginès 28 Alcoholic hepatitis, 204Brian J. Hogan and David William Michael Patch 29 Perforation of the gastrointestinal tract, 211Ian McAllister 30 Intestinal obstruction, 220Kevin McCallion 31 Acute appendicitis, 225Ian McAllister 32 Middle gastrointestinal bleeding, 230Andres Sanchez]Yague 33 Ischemic bowel, 239Ryan B. Perumpail and Shai Friedland 34 Acute severe ulcerative colitis, 242Subrata Ghosh and Marietta Iacucci 35 Gastrointestinal infections, 251Graham Morrison and John S. A. Collins 36 Diverticular disease, 263Jennifer M. Kolb and Tonya Kaltenbach 37 Gastrointestinal complications of HIV disease, 269Emma McCarty and Wallace Dinsmore 38 Gastrointestinal complications in the intensive care unit, 276James J. McNamee and Daniel F. McAuley Index, 282

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Book SynopsisEsophageal Cancer and Barrett's Esophagus, 3E, focuses on these two common and key conditions that affect the esophagus, providing expert guidance to their pathogenesis, cause, prevention, diagnosis and clinical management. Top international names in the field examine each of the many issues involved, using the very latest evidence-based research, and clear, didactic adviceallows the reader to understand the best methods of diagnosis and clinical management of each condition whether early or late stage. Well-illustrated and fully revised to include the latest in ACG/ASG/UEGW guidelines, itis the perfect consultation tool for gastroenterologists and oncologists managing patients with cancer of the esophagus. It is also ideal for teaching residents and fellows optimum patient management, and for identifying areas requiring future research.Table of ContentsList of contributors ix Preface xiii 1 Epidemiology of esophageal carcinoma 1Mohammad H. Shakhatreh and Hashem B El-Serag 1.1 The incidence and mortality related to esophageal cancer 1 1.2 Mortality 2 1.3 Risk factors for EA 2 2 Barrett's esophagus: definition and diagnosis 15Stuart Jon Spechler 2.1 Introduction 15 2.2 Early history of Barrett's esophagus 15 2.3 Early reports on the histology of Barrett's esophagus 16 2.4 Identification of the gastroesophageal junction 16 2.5 Recognition of short segment Barrett's esophagus 17 2.6 Intestinal metaplasia and adenocarcinoma of the esophagus 18 2.7 The problem of cardiac mucosa 18 2.8 Definition of Barrett's esophagus 19 2.9 Diagnostic criteria for Barrett's esophagus 19 2.10 Intestinal metaplasia at the GEJ 20 3 Epidemiology and prevalence of Barrett's esophagus 25Helen G. Coleman, Shivaram K. Bhat and Liam J. Murray 3.1 Introduction 25 3.2 BE prevalence 25 3.3 BE incidence 28 3.4 Etiology and risk factors for BE 30 3.5 Neoplastic progression risk in BE 30 3.6 Conclusions 31 4 Esophageal adenocarcinoma: risk factors 35Mariam Naveed and Kerry B. Dunbar 4.1 Introduction 35 4.2 Gastroesophageal reflux disease (GERD) 35 4.3 Barrett's esophagus (BE) 36 4.4 Obesity 37 4.5 Smoking 37 4.6 Alcohol 38 4.7 Dietary factors 38 4.8 Medication use 38 4.9 H. pylori 39 4.10 Demographics 39 4.11 Summary 39 5 Esophageal motility abnormalities in Barrett's esophagus 45Kumar Krishnan, John E. Pandolfino and Peter J. Kahrilas 5.1 Introduction 45 5.2 Antireflux barrier 45 5.3 Lower esophageal sphincter 46 5.4 Diaphragmatic sphincter and hiatal hernia 46 5.5 Mechanical properties of the relaxed EGJ 47 5.6 Esophageal clearance 48 5.7 Peristaltic dysfunction 49 5.8 Gastric emptying and duodenogastroesophageal reflux 49 5.9 Therapy of motor abnormalities in Barrett's esophagus 50 5.10 Conclusion 50 6 Molecular biology of Barrett's esophagus and esophageal adenocarcinoma 55Ayesha Noorani and Rebecca C. Fitzgerald 6.1 Introduction 55 6.2 Genetic and host susceptibility 55 6.3 Environmental factors contributing to the development of BE 57 6.4 Genomic instability mutations and copy number changes in candidate genes 58 6.5 The advent of next generation sequencing 61 6.6 Future directions and conclusions 63 7 Histology of Barrett's esophagus: metaplasia and dysplasia 69Deepa T. Patil and John R. Goldblum 7.1 Introduction 69 7.2 Normal anatomy and histology 69 7.3 Histology of Barrett's esophagus 69 7.4 Intestinal metaplasia of the EGJ 71 7.5 Barrett's esophagus-related dysplasia 71 7.6 Intramucosal adenocarcinoma (IMC) 72 7.7 Submucosal adenocarcinoma 73 7.8 Morphologic types of dysplasia 73 7.9 Sampling error and observer variation in Barrett's esophagus-related dysplasia 74 7.10 Surrogate biomarkers for assessing risk of esophageal adenocarcinoma 74 8 Helicobacter pylori and esophageal neoplasia 79Arne Kandulski, Marino Venerito and Peter Malfertheiner 8.1 Introduction 79 8.2 H. pylori infection -- gastritis pattern and gastric physiology with impact on gastroesophageal reflux disease 79 8.3 Epidemiological studies -- GERD symptoms, erosive esophagitis and H. pylori 80 8.4 H. pylori, Barrett's esophagus and esophageal adenocarcinoma 81 8.5 H. pylori eradication and GERD 82 8.6 H. pylori and esophageal squamous cell carcinoma 83 8.7 Conclusions 84 9 Screening and surveillance 87Sarmed S. Sami and Krish Ragunath 9.1 Introduction 87 9.2 Screening 87 9.3 Surveillance 90 9.4 Conclusion 93 10 New surface imaging technologies for dysplasia and cancer detection 97 David F. Boerwinkel, Wouter L. Curvers and Jacques J.G.H.M. Bergman 10.1 Introduction 97 10.2 Surface imaging in Barrett's esophagus 98 10.3 Surface imaging for esophageal squamous cell carcinoma 103 10.4 Summary 104 11 New cellular imaging technologies for dysplasia and cancer detection 107Helmut Neumann and Ralf Kiesslich 11.1 Introduction 107 11.2 Confocal laser endomicroscopy 107 11.3 Endocytoscopy 110 11.4 Optical coherence tomography 111 11.5 Molecular imaging in Barrett's 112 11.6 Conclusion 112 12 The role of endoscopic ultrasound in esophageal cancer 115Samad Soudagar and Neil Gupta 12.1 Background 115 12.2 Equipment 115 12.3 Visualized EUS anatomy 115 12.4 Obstacles to accurate EUS staging 116 12.5 Esophageal cancer staging and impact on treatment intervention 117 12.6 T staging 117 12.7 N staging 119 12.8 M staging 120 12.9 Restaging after chemoradiotherapy and surveillance for disease recurrence 120 12.10 Conclusion/summary 121 13 Staging of esophageal adenocarcinoma by CT, PET, and other modalities 125Florian Lordick, Katja Ott, Matthias Ebert, Lars Grenacher, Bernd-Joachim Krause and Christian Wittekind 13.1 Introduction 125 13.2 Endoscopic staging 125 13.3 Staging by external ultrasonography 128 13.4 Staging by radiological examinations 128 13.5 Staging by positron emission tomography (PET) 129 13.6 The value of FDG-PET to predict response to pre-operative treatment 130 13.7 Conclusion: summary of recommended staging procedures 132 14 Medical management of Barrett's esophagus 137Sachin Wani 14.1 Introduction 137 14.2 Assessment of symptoms 137 14.3 Acid suppressive therapies in management of reflux symptoms 138 14.4 Normalization of intraesophageal acid exposure 138 14.5 Management of erosive esophagitis 139 14.6 Maintenance of healed mucosa after endoscopic eradication therapies 139 14.7 Conclusions 140 15 Thermal therapies and photodynamic therapy for early esophageal neoplasia 143Jacques Deviere 15.1 Introduction 143 15.2 Photodynamic therapy 144 15.3 Argon plasma coagulation 144 15.4 Cryotherapy 147 15.5 Conclusion 147 16 RFA for early esophageal neoplasia 151 Daniel K. Chan, Cadman L. Leggett and Kenneth K. Wang 16.1 Background 151 16.2 Device and procedural technique 151 16.3 Efficacy and durability of radiofrequency ablation 154 16.4 Initial treatment response to RFA and risk factors for failed ablation 156 16.5 Endoscopic mucosal resection in combination with radiofrequency ablation 157 16.6 Safety and tolerability of radiofrequency ablation 157 16.7 Subsquamous intestinal metaplasia after radiofrequency ablation 157 16.8 Surveillance following radiofrequency ablation 158 16.9 Conclusions 158 17 The role of endoscopic cryotherapy for treatment and palliation 161Kristle Lee Lynch, Eun Ji Shin and Marcia Irene Canto 17.1 Introduction 161 17.2 Cryotherapy mechanisms of tissue injury 161 17.3 Types of cryotherapy: devices, dosing, and endoscopic application 162 17.4 Efficacy and safety in Barrett's esophagus 164 17.5 Cryotherapy for the treatment of esophageal carcinoma 166 17.6 Summary and future directions 167 18 Endoscopic resection 169Oliver Pech 18.1 Introduction 169 18.2 ER techniques 169 18.3 ER in HGIN and early Barrett's cancer 171 18.4 ER of submucosal Barrett's adenocarcinoma 174 18.5 Conclusions 174 19 Endoscopic submucosal dissection 177Hironori Yamamoto, Tsuneo Oyama and Takuji Gotoda 19.1 Introduction 177 19.2 Indications of ESD for esophageal cancer 177 19.3 Preoperative examination 178 19.4 Techniques of ESD [19--22] for esophageal cancer 178 19.5 Complications 184 19.6 Sedation and anesthesia 185 19.7 Results 185 19.8 Training 185 19.9 Conclusion 186 20 Surgical therapy of early esophageal cancer 189Toshitaka Hoppo and Blair A. Jobe 20.1 Introduction 189 20.2 "Early" esophageal cancer 189 20.3 Indication of surgical resection for early esophageal adenocarcinoma 190 20.4 Strategy of surgical resection for early esophageal adenocarcinoma 190 20.5 Choice of surgical approach and outcomes 191 20.6 Discussion 194 20.7 Conclusion 195 21 Chemoprevention: can we prevent esophageal cancer? 199Janusz Jankowski and Mary Denholm 21.1 Overview 199 21.2 The effect of aspirin on cancer prevention 200 21.3 Risks and adverse effects of aspirin 201 21.4 The role of aspirin in reflux disease 203 21.5 Risk-benefits of aspirin 204 21.6 AspECT trial 205 22 Selection of patients for cancer prevention and eradication 209Aaron J. Small and Gary W. Falk 22.1 Introduction 209 22.2 Patient factors 209 22.3 Cancer risk and grade of dysplasia 210 22.4 Baseline quality measures 212 22.5 The lesion 213 22.6 Predictors of response 215 22.7 Predictors of initial response to therapy 215 22.8 Future considerations 217 22.9 Conclusions 217 23 Combined modality therapy in locally advanced esophageal cancer 221Geoffrey Y. Ku and David H. Ilson 23.1 Introduction 221 23.2 Pre-operative chemotherapy 221 23.3 Post-operative therapy 222 23.4 Chemoradiation for medically inoperably patients 224 23.5 Pre-operative chemoradiation 224 23.6 Pre-operative chemoradiation vs. chemotherapy 225 23.7 Definitive vs. pre-operative chemoradiation 225 23.8 Newer chemoradiation regimens 226 23.9 Targeted therapies 226 23.10 Positron emission tomography-directed therapy 227 23.11 Conclusion 228 24 Surgery in locally advanced esophageal cancer 231Nabil Rizk 24.1 Introduction 231 24.2 Chemotherapy, chemoradiation and surgical complications 231 24.3 Technical considerations 232 24.4 Risks of salvage surgery 233 24.5 Conclusion 234 25 Radiation therapy for locally advanced esophageal cancer 237Heath D. Skinner and Bruce D. Minsky 25.1 Introduction 237 25.2 Definitive therapy in unresectable locally advanced esophageal cancer 237 25.3 Trimodality therapy 240 25.4 Techniques of radiation therapy 243 25.5 Conclusions 245 26 Systemic therapy and targeted agents in advanced esophageal cancer 251Mark A. Lewis and Harry H. Yoon 26.1 Introduction 251 26.2 Chemotherapy 251 26.3 Targeted therapy 253 26.4 Future directions 258 26.5 Conclusions 259 27 Role of endoscopy and nutritional support in advanced esophageal cancer 265Manol Jovani, Andrea Anderloni and Alessandro Repici 27.1 Introduction 265 27.2 Nutritional support in advanced esophageal cancer 266 27.3 Palliative endoscopy in inoperable esophageal cancer 266 27.4 Conclusion 273 Index 277

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Book SynopsisGastroenterology and Hepatology Lecture Notes is a comprehensive yet easy-to-read overview of luminal gastroenterology and hepatology. Covering the epidemiology, causes, clinical features, investigation, treatment and prognosis of all the main gut and liver conditions, it is ideal for both exam preparation and fact finding.Table of ContentsPreface to the second edition vii Preface to the first edition viii About the companion website ix Part I Clinical Basics 1 Approach to the patient with abdominal pain 3 2 Approach to the patient with liver disease 13 3 Approach to the patient with luminal disease 20 4 Nutrition 34 5 Gastrointestinal infections 46 6 Gastrointestinal investigations 53 Part II Gastrointestinal Emergencies 7 Acute gastrointestinal bleeding 63 8 Acute upper and lower gastrointestinal emergencies 67 9 Acute liver failure 75 10 Pancreatobiliary emergencies 81 Part III Regional Gastroenterology 11 Oral cavity 91 12 Oesophagus 93 13 Stomach and duodenum 101 14 Small intestine 107 15 Small and large bowel disorders 115 16 Colon 128 17 Anorectum 135 18 Pancreatic diseases 141 19 Biliary diseases 149 20 Consequences of chronic liver disease 160 21 Liver transplantation 174 22 Alcoholic liver disease 182 23 Non‐alcoholic fatty liver disease 186 24 Viral hepatitides 190 25 Drug‐induced liver injury 204 26 Autoimmune hepatitis 209 27 Liver tumours and lesions 212 28 Vascular liver diseases 218 29 Pregnancy‐related liver disease 229 30 Hereditary and congenital liver diseases 233 Part IV Study Aids and Revision Gastrointestinal history check-list 255 Abdominal examination routine 257 Rectal examination routine 259 Common OSCE cases 260 Surgical sieve 261 Part V Self‐Assessment: Answers Self-assessment: Answers 265 Index 271

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Book SynopsisThis revised and updated second edition of the popular and comprehensive guide to the study of gastroenterology The revised second edition of Essentials of Gastroenterology provides a highly practical and concise guide to gastroenterology. The text covers every major disorder likely to be encountered during both GI training and in clinical practice. It also offers a handbook for preparing for Board examinations (e.g., USMLE and Internal Medicine Board examinations) as well as a handy clinical consultation tool. Fully updated to reflect the latest scientific information and practice guidelines, each section of the book covers a specific area of the gastroenterology tract and follows a standard outline: general information, normal physiology, etiology and pathophysiology, clinical presentation, diagnosis, differential diagnosis, complications, prognosis, and treatment. The text provides easy-to-assimilate information on each disorder and includes the key faTable of ContentsContributor List xi Foreword xv Preface xvii Acknowledgments xix Tribute to Shanthi V. Sitaraman xxi Luminal Gastrointestinal Tract 1Shreya Raja and Melanie S. Harrison 1 Gastroesophageal Reflux Disease 3Shani Woolard and Jennifer Christie 2 Dysphagia 19Emad Qayed and Shanthi Srinivasan 3 Peptic Ulcer Disease 35Meena A. Prasad and Lawrence S. Friedman 4 Common Upper Gastrointestinal Surgeries 49Rebecca G. Lopez and Edward Lin 5 Acute Diarrhea 71Jan]Michael A. Klapproth 6 Chronic Diarrhea 89Sonali S. Sakaria and Robin E. Rutherford 7 Irritable Bowel Syndrome 105Kavya M. Sebastian 8 Inflammatory Bowel Disease 113Jan]Michael A. Klapproth 9 Constipation 133Shreya Raja and Shanthi Srinivasan 10 Colorectal Neoplasms 149Pruthvi Patel and Vincent W. Yang Liver 165JP Norvell 11 Liver Anatomy and Histopathology 167Joel P. Wedd 12 Liver Biochemical Tests 179Nader Dbouk and Samir Parekh 13 Viral Hepatitis 195Anjana A. Pillai and Lawrence S. Friedman 14 Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease 211Stephen H. Berger and Ryan M. Ford 15 Chronic Liver Disease 227Preeti A. Reshamwala 16 Portal Hypertension 245JP Norvell Pancreas and Biliary System 269Stephan Goebel and Lisa Cassani 17 Pancreatic Anatomy and Function 271Field F. Willingham 18 Acute Pancreatitis 283Steven Keilin 19 Chronic Pancreatitis 301Anthony M. Gamboa and Qiang Cai 20 Bile Acid Metabolism 315Nicole M. Griglione and Field F. Willingham 21 Gallstones and Complications 325Julia Massaad Common Problems in Gastroenterology 339Emad Qayed and Meena A. Prasad 22 Acute Gastrointestinal Bleeding 341Tanvi Dhere 23 Abdominal Pain 359Kamil Obideen 24 Jaundice 367Nader Dbouk and Preeti A. Reshamwala 25 Abdominal Emergencies 381Stephan Goebel Picture Gallery 399Sonali S. Sakaria and Saurabh Chawla 26 Classic Skin Manifestations 401Melanie S. Harrison, Robert A. Swerlick, and Zakiya P. Rice 27 Classic Images 413Pardeep K. Mittal, Courtney C. Moreno, William C. Small, and Saurabh Chawla 28 Classic Pathology 443Sujaata R. Dwadasi, Mary M. Flynn, Stephen K. Lau, and Meena A. Prasad Index 471

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Book SynopsisYAMADA''S Handbook of Gastroenterology The GI doctor's classic portable, clinically-focused and authoritative reference, revised and updated The revised and updated fourth edition of Yamada's Handbook of Gastroenterology focuses on the clinical aspects of patients presenting with gastrointestinal and liver disease. The book is a portable, quick reference tool designed to assist trainees and practicing gastroenterologists in the practical assessment and clinical management of patients. The Handbook is divided into two parts; the first is symptom focused and the second highlights diseases. Each chapter features key practice points, essentials of diagnosis, potential pitfalls and case studies. In addition, the book includes multiple choice questions and answers to enhance understanding. The fourth edition includes updated clinical practice guidelines from National Societies (American Gastroenterological Association, American Society for GastrointestinTable of ContentsColor Plates List vii Preface ix List of Abbreviations xi Part 1 Approach to Patients with Gastrointestinal Symptoms or Signs 1 The Patient with Dysphagia or Odynophagia 3 2 The Patient with Heartburn or Chest Pain 13 3 The Patient with Gastrointestinal Bleeding 23 4 The Patient with Unexplained Weight Loss 37 5 The Patient with Nausea and Vomiting 47 6 The Patient with Abdominal Pain 57 7 The Patient with Gas and Bloating 69 8 The Patient with Ileus or Obstruction 79 9 The Patient with Constipation 89 10 The Patient with Diarrhea 99 11 The Patient with an Abdominal Mass 115 12 The Patient with Jaundice or Abnormal Liver Biochemical Tests 125 13 The Patient with Ascites 143 14 The Patient Requiring Nutritional Support 157 15 The Patient Requiring Endoscopic Procedures 171 Part 2 Specific Gastrointestinal Diseases 16 Motor Disorders of the Esophagus 187 17 Gastroesophageal Reflux Disease and Eosinophilic Esophagitis 197 18 Esophageal Neoplasia 207 19 Disorders of Gastric Emptying 217 20 Acid Peptic Disorders 229 21 Functional Dyspepsia 239 22 Gastric Neoplasia 245 23 Celiac Disease 255 24 Short Bowel Syndrome 265 25 Small Intestinal Neoplasia 273 26 Diverticular Disease of the Colon 281 27 Irritable Bowel Syndrome 289 28 Inflammatory Bowel Disease 299 29 Colonic Neoplasia 317 30 Anorectal Diseases 327 31 Pancreatitis 335 32 Pancreatic Neoplasia 349 33 Biliary Tract Stones and Cysts 359 34 Viral Hepatitis 369 35 Genetic and Metabolic Diseases of the Liver 383 36 Cholestatic Liver Diseases 391 37 Alcoholic Liver Disease 401 38 Autoimmune Hepatitis 407 39 Complications of Cirrhosis 413 40 Primary Hepatic Neoplasms 423 41 Infections of the Gastrointestinal Tract 431 42 Gastrointestinal Vascular Lesions 447 43 Medical, Surgical, and Endoscopic Treatment of Obesity 457 44 Questions and Answers 463 Index 517

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Book SynopsisTable of ContentsPreface Section 1 Introduction 1 Liver Tests Section 2 Take-Home Primers: Managing The Patient with Unexplained Abnormal Liver Tests 2 Primary Care Section 3 Take-Home Primers: Managing The Patient With Unexplained Abnormal Serum Liver Tests In Secondary Care 3 Global Perspective 4 Intensive Care 5 Infections Affecting The Liver In Immuno 6 The Post-Operative Patient 7 Pregnancy 8 Endocrinology And Metabolic Diseases (Including Diabetes) 9 Abnormal Serum Liver Tests In Cardiac Disease 10 Respiratory Disease 11 Gastroenterology 12 Renal medicine 13 Dermatology 14 Oncology 15 Haematology 16 Mental health & Neurology 17 Non-alcoholic Fatty Liver Disease (NAFLD) Section 4 Practical Issues In Patients With Liver Abnormalities 18 Prescribing In Patients With Abnormal Liver Tests Or Liver Disease - A Pragmatic Approach 19 Invasive Procedures In Those With Liver Disease 20 Diagnosing Drug Induced Liver Injury Index

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Book SynopsisShould be read by anyone with a body. . . . Relentlessly researched and undeniably smart.The New York TimesNamed one of BuzzFeed''s Best Books of 2021What Doesn't Kill You is the riveting account of a young journalist's awakening to chronic illness, weaving together personal story and reporting to shed light on living with an ailment forever.Tessa Miller was an ambitious twentysomething writer in New York City when, on a random fall day, her stomach began to seize up. At first, she toughed it out through searing pain, taking sick days from work, unable to leave the bathroom or her bed. But when it became undeniable that something was seriously wrong, Miller gave in to family pressure and went to the hospitalbeginning a yearslong nightmare of procedures, misdiagnoses, and life-threatening infections. Once she was finally correctly diagnosed with Crohn's disease, Miller faced another battle: accepting that sh

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Book Synopsis“Fascinating.…[Ravella’s writing] breathes life into biological functions.” —Grace Wade, New Scientist A riveting investigation of inflammation—the hidden force at the heart of modern disease—and how we can prevent, treat, or even reverse it.Trade Review"A fascinating, case-oriented story of inflammation, diet and disease." -- Andrew Robinson - Nature"Compelling, thoughtful and rigorously researched." -- Rhys Blakely - Times"As gripping as a mystery story and as useful as a self-help book." -- Bee Wilson, author of First Bite and The Way We Eat Now"Controlling inflammation is the key to good health, and this beautifully written and researched book is the best way to understand it." -- Tim Spector, author of Food for Life"Shilpa Ravella’s deeply researched, far-ranging book shows us how inflammation links the pathologies of modern life. Even better, it lets us in on a practicing gastroenterologist’s insights on the role of diet and what we can do to stop or even reverse the effects of ‘inflammaging.’ This necessary book has the power to change the way we think and eat." -- Amit Majmudar, MD, author of What He Did in Solitary"Ravella’s fascinating, poetic, exploration of the body, food, and history will sweep you up sentence by sentence. A book that could not only reshape readers’ understanding of their own systems and choices but possibly medicine itself." -- Lauren Sandler, author of This Is All I Got"Inflammation is a double-edged sword that heals and destroys; it has already saved your life, but most likely will contribute to ending it…Shilpa Ravella takes us on a grand tour of the medical science and…the whys and ways of this fundamental process." -- Martin J. Blaser, MD, author of Missing Microbes"A must-read for anyone interested in cutting-edge medicine. It is no exaggeration to say that low-level inflammation may be an insidious factor contributing to numerous diseases of aging, and Shilpa Ravella, a gastroenterologist with a writer’s gift for translating complex science into clean, beautiful prose, is the perfect person to tell this gripping tale." -- Kathleen McAuliffe, author of This Is Your Brain on Parasites"A spellbinding tale taking us from the early Greek physicians to the COVID-19 pandemic.… The insights Shilpa Ravella reveals point to a pathway that can enhance both our personal well-being today and that of the planet we pass on to our grandchildren." -- Walter C. Willett, MD, DrPH, professor of epidemiology and nutrition, Harvard T.H. Chan School of Public Health"Critical to our health is understanding how to stave off inflammatory diseases.… Shilpa Ravella makes this complex topic accessible and engaging, winding together a wonderful historical perspective with cutting-edge science." -- Justin Sonnenburg, coauthor of The Good Gut

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Book SynopsisCombat digestive symptoms and get trustworthy information to keep yourself healthy from the inside out Gut Health For Dummies can help you restore and optimize your gut and its microbes, for better health day to day. Clear away the confusion and debunk the unscientific information found on social media with this essential guide. You'll learn what makes the gut so important and how it influences the rest of your body, including your brain. Figure out how to manage digestive disorders and gut symptoms, confidently navigate the world of probiotics and other gut health supplements, and find inspiration for the diet and lifestyle changes that will support your health for years to come. This jargon-free Dummies guide will set you on the right path, giving you tips for adopting healthy habits, healing your gut biome, and being proactive for wellbeing and longevity. Learn how the gut works and explore what may be causing your digestive symptomsCombat IBS and other gut disorders with the latest scienceSteer clear of myths, scams, and misinformationdiscover what actually worksBe proactive in managing your gut health to ensure robust health and wellbeing at every ageFor those who currently experience gastrointestinal symptoms, and anyone interested in learning about evidence-based ways to optimize gut health, Gut Health For Dummies is the right choice.

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Book SynopsisWe know that gut health is key to our wellbeing so it''s high time we break the taboos and get familiar with our poo!In Regular, digestive health expert and medical nutritionist Tamara Duker Freuman tackles this less than glamorous topic and teaches you all you need to know about your bowel health. Offering tailored solutions for the most common - and uncommon - issues, including irritable bowel syndrome, reflux and Coeliac disease, this book will guide readers to identify the specific cause of their irregularity and provide personalised solutions and tips, including:-questions to take to your next doctor''s visit-an interactive quiz that will help you identify the quality of your stool -tables and charts listing problematic foods and suggested alternatives-sample menus, and more.Whether you or a loved one suffers from chronic diarrhoea or constipation, Regular covers the most common causes of bowel irregularity with detailed descri

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Book SynopsisA comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Whole-body health can be restored with Dr. Stengler's integrative program, which includes prebiotic and probiotic recipes.Here's the truth: the health of your gut (including your microbiome) affects the health of all organs in the body. Your gut is also the epicenter of your immune system, so supporting it is crucial if you want more resiliency to infection or to be less prone to autoimmune disorders—or even cancer. The Holistic Guide to Gut Health dives into the gut-body connection so you can discover the true cause of many of your health issues—including leaky gut—and how to resolve them through scientific and clinically proven holistic methods.Whether you’re concerned about a specific condition or overall health, this book offers recommendations for nutrition, supplements, and lifestyle habits as well as gut-healing recipes to support your goals. You’ll also get Dr. Stengler's successful healing protocols for many common digestive issues such as acid reflux (GERD), candida overgrowth, IBS and IBD, and SIBO; and even non-digestive issues such as allergies and asthma, anxiety, depression, diabetes, fatigue, insomnia, joint pain and osteoarthritis, menopause systems, and PMS. The Holistic Guide to Gut Health arms you with all you need to make the right choices for you on your gut-healing journey.

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Book SynopsisThere have been significant developments in the fields of gastroenterology and hepatology since the previous edition and this new edition has been entirely revised, updated and considerably expanded. The format and layout have also been updated to include key points at the start of each chapter, bulleted lists and text boxes for tips and warnings. A new author team - which, for the first time, is international - has brought a new global perspective to this book. This is still the leading book for trainees/fellows in gastroenterology and hepatology, as well as junior doctors and general medicine interns. The series title is ''Pocket Consultant'' - and that''s exactly what the reader gets - the advice and guidance of a consultant on hand when and where they need it.Trade Review"This is a very accessible book: the style is didactic, all problems are expressed in a very pragmatic manner [...] all information sought can be found easily (the index is close to perfection); [the book] will stay very visible on my desk in the ward for everyday needs of invaluable information from an up-to-date and sound source." Digestive and Liver Disease "Overall I would strongly recommend this book as a starter text for senior SHOs and junior registrars. Those more experienced will also find it a useful revision tool." Dr Kate Evans SpR Gastroenterology "This is a fantastic book for newly appointed gastroenterology registrars/fellows and other professionals with an interest in the field." TiGs "This is a welcome third edition of a well known book for a wide audience. Dr Simon Travis has enlisted the help of gastroenterology experts from a larger field giving the book a more global appeal." MRCP Gastroenterology Specialist Registrar On previous editions ... "The 'Pocket Consultants' are a popular series of books aimed at doctors in training, both under- and post-graduate. Thus this is akin to carrying around a consultant-like opinion and font of knowledge in your pocket, and acting as an aid to making your opinion comparable to that of a senior colleague. It is also like having a slice out of one of the bigger textbooks, but being able to carry it around, and maybe, surreptitiously look up a topic." Gastroenterology Today "This little book is valuable support for junior hospital staff and general practitioners." Scandinavian Journal of GastroenterologyTable of ContentsPreface vii Acknowledgements ix 1 Alimentary Emergencies 1 2 Oesophagus 49 3 Stomach and Duodenum 75 4 Pancreas 111 5 Liver 133 6 Gall Bladder and Biliary Tree 185 7 Small Intestine 205 8 Inflammatory Bowel Disease 243 9 Large Intestine 285 10 Irritable Bowel Syndrome 333 11 Gastrointestinal Infections 347 12 Nutrition 369 13 The Gut in Systemic Disorders 395 14 Procedures and Investigations 409 Appendices 1 Useful addresses 435 2 Further reading 442 3 Height and weight charts 450 4 Diagnostic dilemmas 455 Index 457

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Book SynopsisFatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It appeals to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease. It will improve your diagnostic acumen for people with abnormal liver tests, advance your knowledge about this important subject and help with your specialist or undergraduate exams, and management of a common disorder.Trade Review"A superb updated review of a topic of dramatically increasing importance, written by leading authorities in the field. The book is well organised and balanced with excellent homogeneity" "A comprehensive book of invaluable help in diagnosing and managing NAFLD/NASH. Again, an outstanding source of current data concerning this epidemiologically important problem" Digestive and Liver Disease "Fatty Liver Disease is a state-of-the-art textbook coauthored by a number of top-notch experts and should be viewed as an invaluable contribution to the proper management of fatty liver diseases and all its coexisting conditions." New England Journal of Medicine, 353;20 November 2005Table of ContentsContributors. Preface. 1 Overview: an introduction to NASH and related fatty liver disorders. 2 Pathology of hepatic steatosis, NASH and related conditions. 3 The epidemiology and risk factors of NASH. 4 Insulin resistance in NAFLD: potential mechanisms and therapies. 5 NASH as part of the metabolic (insulin resistance) syndrome. 6 NASH is a genetically determined disease. 7 The pathogenesis of NASH: human studies. 8 Animal models of steatohepatitis. 9 Fatty acid metabolism and lipotoxicity in the pathogenesis of NAFLD/NASH. 10 Cytokines and inflammatory recruitment in NASH: experimental and human studies. 11 Mitochondrial injury and NASH. 12 Cell biology of NASH: fibrosis and cell proliferation. 13 Clinical manifestations and diagnosis of NAFLD. 14 The clinical outcome of NAFLD including cryptogenic cirrhosis. 15 Practical approach to the diagnosis and management of people with fatty liver diseases. 16 Management of NASH: current and future perspectives on treatment. 17 NAFLD, NASH and orthotopic liver transplantation. 18 NAFLD/NASH is not just a ‘Western’ problem: some perspectives on NAFLD/NASH from the East. 19 NAFLD/NASH in children. 20 Steatohepatitis resulting from intestinal bypass. 21 Specific disorders associated with NAFLD. 22 Hepatocellular carcinoma in NAFLD. 23 Does NASH or NAFLD contribute to comorbidity of other liver diseases?. 24 Recent advances. Index

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Book SynopsisIntestinal failure is a challenging, emerging field that has been the subject of much research and debate in recent years and has only recently become widely accepted as a distinct clinical syndrome. This comprehensive book provides an in-depth review of scientific theory and clinical practice relating to intestinal failure with specific emphasis on assessment and management as part of a multidisciplinary team. Compiled by an internationally recognised editorial team, the book provides a practical how-to guide to the management of adult and pediatric patients with intestinal failure, focusing on quality-of-life issues that are at the heart of patient care. World experts from centers of excellence share their clinical experience and expertise, offering the first ever authoritative resource on intestinal failure All aspects of patient management are covered, from diagnosis and medical and surgical manageTrade Review“This is a useful, comprehensive, practical guide to modern assessment and management of complex intestinal failure cases. The book was compiled by experienced clinicians resulting in an authoritative, novel resource on intestinal failure.” (Doody's Reviews, March 2009) “A comprehensive overview of the far-reaching effects of loss of the gut. It is a good update on state-of-the-art treatment of patients … and the authors also go behind the scenes to discuss aspects of care … .Intestinal Failure gives insight into recent progress in the understanding of intestinal failure, covers the most important topics that the clinician working in this area will face … .Despite major improvements in the survival of patients with severe intestinal failure, the treatment of patients with poor gut function remains an exciting and challenging area of medicine, and this book enables the reader to have a good overview and understanding of the topic.” (New England Journal of Medicine, November 2008) Table of ContentsList of Contributors. Foreword. Preface. Abbreviations. Part 1 Introduction. 1 The History of Intestinal Failure and Transplantation: Alan N. Langnas (University of Nebraska Medical Center). Part 2 Intestinal Physiology and Immunology. 2 Intestinal Morphology, Intestinal Regeneration and the Promise of Tissue Engineering: David A.J. Lloyd (St Mark’s Hospital Harrow) and Simon M. Gabe (St Mark’s Hospital Harrow). 3 Basic Physiology of Motility, Absorption and Secretion: Greger Lindberg (Karolinska Institutet). 4 Immunology of the Small Intestine: Liam O’Mahony (University College Cork). 5 Intestinal Adaptation: The Biology of the Intestinal Response to Resection and Disease: Marc S. Levin (St Louis VA Medical Center) and Deborah C. Rubin (Washington University School of Medicine). Part 3 Intestinal Failure: Definition and Pathophysiology. 6 Intestinal Failure: Definitions and Classifications: Dominique M. Jan (Columbia University). 7 Causes of Intestinal Failure in the Newborn: Yigael Finkel (Karolinska Institutet). 8 Congenital Enteropathies Causing Permanent Intestinal Failure: Olivier Goulet (University of Paris-Descartes). 9 Causes of Intestinal Failure in the Adult: Harry C. Sax (The Warren Alpert Medical School of Brown University). 10 Intestinal Failure Related to Bariatric Surgery: Jon S. Thompson (University of Nebraska Medical Center). 11 Inflammatory Bowel Disease and the Short Bowel Syndrome: Ramsey K. Umar (Feinberg School of Medicine) and Alan L. Buchman (Feinberg School of Medicine). 12 Motility Disorders: Hayat Mousa (Center for Advanced Research in Neuromuscular Gastrointestinal Disorders (C.A.R.I.N.G)) and Carlo Di Lorenzo (The Ohio State University and Columbus Children’s Hospital). Part 4 Assessment and General Management of Intestinal Failure. 13 Assessment of Intestinal Failure Patients: Clarivet Torres (Georgetown University Hospital). 14 Guidelines for Home Parenteral Nutrition Support in Chronic Intestinal Failure Patients: Bernard Messing (Reference Centre for Rare Digestive Diseases), Francisca Joly (Reference Centre for Rare Digestive Diseases) and Virginie Colomb (Reference Centre for Rare Digestive Diseases). 15 Home Parenteral Nutrition: Complications, Survival, Costs and Quality of Life: John K. DiBaise (Mayo Clinic). 16 Vascular Access, Including Complications: Sanja Kolaček (Children’s Hospital Zagreb) and Julije Meštrović(Spit University Hospital). 17 Enteral Support for Children with Intestinal Failure: Daniel S. Kamin (Children’s Hospital, Boston) and Christopher Duggan (Children’s Hospital, Boston). 18 The Use of Enteral Nutrition in the Adult with Intestinal Failure: Khursheed N. Jeejeebhoy (University of Toronto). 19 The Enteric Flora in Intestinal Failure: Small Intestinal Bacterial Overgrowth and Gut-Derived Sepsis: Eamonn M.M. Quigley (National University of Ireland, Cork), Rodrigo Quera (Hospital Clinico Universidad de Chile) and Ahmed Abu-Shanab (National University of Ireland, Cork). 20 Management of Complex Fluid and Electrolyte Disturbances: Stuart S. Kaufman (Georgetown University Transplant Institute and Children’s National Medical Center) and Erin M. Fennelly (Georgetown University Transplant Institute). 21 Intestinal Failure-Associated Liver Disease: Sue V. Beath (Birmingham Children’s Hospital) and Jeremy M. Woodward (Addenbrooke’s Hospital). 22 Psychiatric Issues in the Assessment of the Patient with Intestinal Failure: James H. Sorrell (Nebraska Medical Center). 23 Munchausen Syndrome by Proxy: Paul E. Hyman (University of Kansas School of Medicine) and Brenda Bursch (David Geffen School of Medicine at UCLA). Part 5 Pharmacological Approaches to Intestinal Failure. 24 Luminal Nutrient Factors in Intestinal Adaptation and Their Use in Therapy: Jon A. Vanderhoof (Children’s Hospital, Boston) and Rosemary J. Young (Boys Town National Research Hospital). 25 The Role of Humoral Factors in Intestinal Adaptation: Jennifer N. Woodard (University of Illinois at Urbana-Champaign) and Kelly A. Tappenden (University of Illinois at Urbana-Champaign). Part 6 Autologous Reconstruction of the GI Tract. 26 Autologous Reconstruction of the GI Tract: Debra Sudan (University of Nebraska). Part 7 Organ Replacement Therapy for Intestinal Failure. 27 Intestinal Transplantation: Indications and Patient Selection: Kareem M. Abu-Elmagd (University of Pittsburgh Medical Center). 28 Isolated Small Bowel Transplantation and Combined Liver-Small Bowel Transplantation: Douglas G. Farmer (Dumont-UCLA Transplant Center). 29 Living Donor Intestinal Transplantation: Enrico Benedetti (University of Illinois at Chicago), Fabrizio Panaro (University of Illinois at Chicago) and Giuliano Testa (University of Chicago Medical Center). 30 Isolated Liver Transplantation for Intestinal Failure-Associated Liver Disease: Jean F. Botha (University of Nebraska Medical Center) and Alan N. Langnas (University of Nebraska Medical Center). 31 Preservation of the Intestine: Vincent B. Nieuwenhuijs (University Medical Center Groningen), Mihai Oltean (Sahlgrenska University Hospital), Henri G. Leuvenink (University of Groningen) and Rutger J. Ploeg (University Medical Center Groningen). 32 Immediate Postoperative Care of the Intestinal Transplant Recipient: Gabriel J. Hauser (Georgetown University Children’s Medical Center), Jeffrey S. Plotkin (Georgetown University Hospital) and Thomas Fishbein (Georgetown University Hospital). 33 Surgical Complications of Intestinal Transplantation: Wendy J. Grant (University of Nebraska Medical Center). 34 Infections in Small Bowel Transplant Recipients: Alison Freifeld (University of Nebraska Medical Center) and Andre Kalil (University of Nebraska Medical Center). 35 Immunosuppression after Intestinal Transplantation: Raquel Garcia-Roca (University of Minnesota) and Rainer Gruessner (University of Arizona). 36 Immunology of Intestinal Allograft Rejection: Kenneth A. Newell (Emory University) and Jonathan P. Fryer (Feinberg School of Medicine). 37 Histopathology of Intestinal Transplantation: Tong Wu (University of Pittsburgh Medical Center) and Anthony J. Demetris (University of Pittsburgh Medical Center). 38 Long-Term Management of Intestinal Transplant Recipients: Frances R. Malone (Children’s Hospital and Regional Medical Center Seattle) and Simon P. Horslen (Children’s Hospital and Regional Medical Center Seattle). 39 Management of Posttransplant Lymphoproliferative Disease: Thomas G. Gross (The Ohio State University). 40 Results of Intestinal Transplantation: David R. Grant (University of Toronto) and Shimul A. Shah (University of Massachusetts Memorial Medical Center). 41 Psychosocial Assessment and Management of the Transplant Patient/Family in Intestinal Transplantation: Jodi Gentleman (The Nebraska Medical Center), Leonard W. Penkoski (University of Nebraska Medical Center). and James H. Sorrell (Nebraska Medical Center). 42 Financial, Economic and Insurance Issues Pertaining to Intestinal Transplantation: When Is Too Much Not Enough?: Roger W. Evans (Consultant in Health Care Rochester). Index

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Book SynopsisThis concise introduction to the gastrointestinal system encapsulates the fundamental facts and principles of this rapidly growing and changing specialty. Written by experienced clinicians and teachers, the text covers the basic concepts of both the science surrounding the gastrointestinal system and the basics of clinical practice in an accessible, lucid format.Now fully supported by a companion website at www.ataglanceseries.com/gastro containing interactive MCQs and downloadable digital flashcards, The Gastrointestinal System at a Glance is the ideal revision aid for medical and allied health students, and provides valuable insight for anyone seeking a comprehensive and concise guide to this subject area. Fully revised and updated to include further coverage of diagnostic and therapeutic endoscopy, revised liver chapters and a new chapter on embryology Now in full colour throughout Table of ContentsPreface 6 Acknowledgements 6 List of abbreviations 7 Introduction and overview 8 Part 1 Structure and function 1 Mouth and teeth 10 2 Salivary glands 12 3 Tongue and pharynx 14 4 Oesophagus 16 5 Stomach 18 6 Duodenum 20 7 Pancreas 22 8 Liver 24 9 Biliary system 26 10 Hepatic portal system 28 11 Jejunum and ileum 30 12 Caecum and appendix 32 13 Colon 34 14 Rectum and anus 36 Part 2 Integrated function 15 Embryology 38 16 Enteric motility 40 17 Enteric endocrine system 42 18 Enteric and autonomic nerves 44 19 Mucosal immune system 46 20 Digestion and absorption 48 21 Digestion of carbohydrates, proteins and fats 50 22 Digestion of vitamins and minerals 52 23 Nutrition 54 24 Fluid and electrolyte balance 56 25 Hepatic metabolic function 58 26 Hepatic synthetic function 60 27 Hepatic detoxification and excretion 62 Part 3 Disorders and diseases 28 Nausea and vomiting 64 29 Diarrhoea 66 30 Constipation 68 31 Functional disorders and irritable bowel syndrome 70 32 Gastro-oesophageal reflux and hiatus hernia 72 33 Peptic ulcer and Helicobacter pylori 74 34 Gastroenteritis and food poisoning 76 35 Gastrointestinal system infections 78 36 Ulcerative colitis and Crohn’s disease 80 37 Coeliac disease 82 38 Obesity and malnutrition 84 39 Colon and rectal cancer 86 40 Gastrointestinal, pancreatic and liver tumours 88 41 Haemorrhoids and anorectal disease 90 42 Gallstones and pancreatitis 92 43 Hepatitis and acute liver disease 94 44 Cirrhosis and chronic liver disease 96 Part 4 Diagnosis and treatment 45 History, examination and tests 98 46 Diagnostic endoscopy 100 47 Therapeutic endoscopy 102 48 Radiology and imaging 104 49 Functional tests 106 50 Pharmacotherapy 108 51 Gastrointestinal surgery 110 Index 112

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Book SynopsisThe Evidence-based Practice Workbook is an ideal tool for use by GPs, medical specialists and other healthcare professionals to learn the concepts of evidence-based practice (EBP). Practical and interactive, this workbook provides simple methods to help health professionals find and use the best evidence to answer clinical questions, developing their skills in: asking clinical questions searching for answers discriminating good from poor information and research using the answers to make clinical decisions. This attractive, colour workbook provides a clear explanation of EBP skills and concepts. Written by internationally respected authors, this expanded and updated edition has been developed from evidence-based practice workshops run by the Centre for Evidence-Based Medicine at the University of Queensland and Oxford, and contains information and exercises to help health professionals learn how to use EBP in their clinicaTable of ContentsNote from the authors iv Acknowledgements iv Introduction to this workbook v How to use this workbook vi Part 1: Introduction to evidence-based practice 1 What is evidence-based practice? 3 Some evidence-based cases 14 Part 2: The steps in evidence-based practice 19 EBP Step 1: Formulate an answerable question 21 EBP Step 2: Track down the best evidence 39 EBP Step 3: Critically appraise the evidence 71 EBP Step 4: Apply the evidence 133 Part 3: Further critical appraisal exercises 141 Critical appraisal of studies for a prognosis question 143 Critical appraisal of studies for a diagnostic test accuracy question 161 Part 4: Reflections and further information 175 How am I doing? Diary of a reflective practitioner 177 Useful sources of evidence 182 Further reading 185 Glossary 186 Answers to quizzes and appraisals 191 Endpiece 198 Index 199

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Book SynopsisGastroenterology is a critically important specialty in medicine, encompassing the GI tract and two vital organs - the pancreas and the liver. Gastroenterology: Clinical Cases Uncovered includes reference to the new JCHMT curriculum for acute and internal medicine concerning gastroenterology and hepatology and presents real-life patient cases and outcomes as seen on the wards and in exams leading students through a practical approach to recognize, understand, investigate and manage gastroenterological and hepatological disorders and conditions. Following a question-answer approach, with self-assessment MCQs, EMQs and SAQs, and a ''refresher'' section on basic science, Gastroenterology: Clinical Cases Uncovered features investigations and the treatment options available for patients with upper and lower GI disorders, liver disease, biliary and pancreatic disease, and problems of nutrition. Gastroenterology: Clinical Cases Uncovered is ideal for medical stTable of ContentsPreface, vii How to use this book, viii List of abbreviations, ix Part 1 Basics, 1 Basic science, 1 Approach to the patient, 14 Part 2 Cases, 29 Upper gastrointestinal Case 1 A 61-year-old woman with progressive dysphagia, 29 Case 2 A 52-year-old man with atypical chest pain, 34 Case 3 A 57-year-old woman with upper abdominal discomfort, 40 Case 4 A 36-year-old man with upper abdominal discomfort and heartburn, 45 Case 5 A 27-year-old woman with nausea and vomiting, 51 Case 6 A 73-year-old man with haematemesis and melaena, 56 Case 7 A 68-year-old woman with fatigue, weight loss and altered bowel habit, 63 Lower gastrointestinal Case 8 A 23-year-old woman with constipation, 69 Case 9 A 24-year-old woman with chronic diarrhoea, 74 Case 10 A 51-year-old woman with acute nausea, vomiting and diarrhoea, 80 Case 11 A 79-year-old woman with altered bowel habit and weight loss, 85 Case 12 A 54-year-old man with rectal bleeding, 90 Case 13 A 66-year-old woman with anaemia, 95 Liver disease Case 14 A 64-year-old man with abnormal liver function tests, 100 Case 15 A 45-year-old man with acute jaundice, 109 Case 16 A 53-year-old woman with jaundice and abnormal liver tests, 115 Case 17 A 53-year-old man with abdominal swelling, 120 Case 18 A 36-year-old man who drinks alcohol, 125 Biliary and pancreatic disease Case 19 A 79-year-old man with right upper quadrant colicky abdominal discomfort, 131 Case 20 A 19-year-old man with acute abdominal pain, 136 Nutrition Case 21 A 35-year-old woman with anorexia, 143 Case 22 A 48-year-old man with an increased body mass index, 148 Functional disorders Case 23 A 21-year-old student with chronic abdominal pain, 153 Part 3 Self-assessment, 159 MCQs, 159 EMQs, 162 SAQs, 166 Answers, 167 Further reading, 173 Index of cases by diagnosis, 175 Index, 177 The colour plate section can be found facing p.54.

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Book SynopsisColorectal cancer is a common cause of morbidity and mortality in which prevention, screening and early detection are vital. Beginning with the patient perspective and following the patient pathway, this new second edition covers epidemiology and prevention, screening programmes, decision support networks, the role of primary care, and supportive care for patients with colorectal cancer. The ABC of Colorectal Cancer provides the core knowledge on clinical genetics, diagnosis, imaging, therapy and surgery options and the latest evidence based guidelines for treating and managing colorectal cancer patients within the multidisciplinary team. Highly illustrated and accessible, it covers the full spectrum of the disease to provide the basis to make a real difference to clinical management. This is an invaluable practical guide for the non-specialist on all aspects of colorectal cancer, and is ideal for general practitioners, junior doctors, nurses and allied health professTrade Review“This short clinical review book of CRC strikes an excellent balance being both concise but with thorough and up-to-date coverage of the subject matter. The chapters based on their size, layout, and supporting figures are very approachable and I would suspect the book to be very useful to its intended audience of general practitioners and physicians in training. The text would seem to be most useful to those practicing clinical medicine, but could also serve as supplemental reading for those preparing for board-type examinations.” (Gastroenterology, 1 August 2012) “The information in the ABC of Colorectal Cancer is very well presented and the coverage is more than a GP would need in clinical practice.” (Australian Family Physician, 4 April 2012)Table of ContentsContributors vii Preface ix 1 The Patient Perspective 1 Kevin Bond 2 Epidemiology and Prevention 4 Peter Boyle, Patrick Mullie, Maria Paula Curado and David Zaridze 3 Pathways of Carcinogenesis 8 Michael Christie and Oliver Sieber 4 Clinical Genetics in the Management of Colon Cancer 13 Kai Ren Ong, Vicky Bowyer and Trevor Cole 5 Screening for Colorectal Cancer 19 Julietta Patnick and Wendy S. Atkin 6 Decision Support Networks 22 Matthew Kelly, Mark Austin and Sir Michael Brady 7 Pathology of Colorectal Cancer 26 Mohammad Ilyas 8 Imaging of Colorectal Cancer 31 Andrew Slater 9 The Role of Primary Care 36 Sue Wilson and Richard Hobbs 10 Radiotherapy for Rectal Cancer 40 Andrew Weaver 11 Surgical Interventions 44 Shazad Ashraf and Neil Mortensen 12 Adjuvant Therapy 48 Zenia Saridaki-Zoras and David Kerr 13 Treatment of Advanced Disease 52 David Watkins and David Cunningham 14 Innovative Treatment for Colorectal Cancer 58 Joanne L. Brady and David Kerr 15 Supportive Care for Patients with Colorectal Cancer 63 Pauline McCulloch and Annie Young 16 Follow-up 69 John Primrose Index 74

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Book SynopsisThis comprehensive resource for fellows/trainees and candidates for recertification in gastroenterology summarizes the field in a modern, fresh format. Prominent experts from around the globe write on their areas of expertise, and each chapter follows a uniform structure. The focus is on key knowledge, with the most important clinical facts highlighted in boxes. Color illustrations reinforce the text.Table of ContentsContributors. Preface. Foreword. Part 1: Pathobiology of the Liver and Biliary Tract. 1 Anatomy, Embryology and Histology (Nirusha Lachman, Wojciech Pawlina). 2 Immunology of the Liver and Mechanisms of Inflammation (Konstantinos N. Lazaridis). Part 2: Diagnostic Approaches in Liver Disease. 3 Approach to History Taking and Physical Examination in Liver and Biliary Disease (David D. Douglas). 4 Assessment of Abnormal Liver Injury Tests (Mashal Jatoi Batheja, Hugo E. Vargas). 5 Imaging of the Liver and Biliary Tree (Alvin C. Silva). 6 ERCP and Biliary Manometry (Todd H. Baron). 7 Endoscopic Techniques used in the Management of Liver and Biliary Tree Disease: EUS (Ferga C. Gleeson, Elizabeth Rajan). 8 Upper Gastrointestinal Endoscopy in the Management of Liver Disease (Hugo E. Vargas). 9 Liver Biopsy and Paracentesis (John J. Poterucha, Timothy J. Gunneson). Part 3: Problem-Based Approach to Liver Disease. 10 Jaundice and Pruritus (Andrea Gossard, Keith Lindor). 11 Liver Mass Found Incidentally on Abdominal Imaging (Thomas J. Byrne). 12 Right Upper Quadrant Abdominal Pain (Feng Li, Cuong Nguyen). 13 Acute Liver Failure (J. Eileen Hay). Part 4: Problems Related to Chronic Liver Disease. 14 Portal Hypertension (Nayantara Coelho-Prabhu, Patrick S. Kamath). 15 Hepatocellular Carcinoma (Lewis R. Roberts). 16 Pregnancy and Liver Disease (Elizabeth J. Carey, J. Eileen Hay). 17 Biliary Atresia and Cystic Fibrosis: Transitioning Care from Pediatrics to Internal Medicine (Veena Venkat, Benjamin L. Shneider). Part 5: Diseases of the Liver. 18 Acute Viral Hepatitis: Hepatitis A, Hepatitis E and Other Viruses (Juan F. Gallegos-Orozco, Jorge Rakela). 19 Hepatitis B and C (W. Ray Kim, John J. Poterucha). 20 Bacterial and Other Non-Viral Infections of the Liver (Maria Teresa A. Seville, Ann McCullough, Shimon Kusne). 21 Metabolic Liver Diseases (John B. Gross). 22 Hepatic Steatosis and NAFLD (Paul Angulo). 23 Drug-induced Liver Injury (Einar S. Björnsson, Naga Chalasani). 24 Alcoholic Liver Disease (Helga Paula, Vijay Shah). 25 Autoimmune Liver Diseases (Jayant A. Talwalkar, Keith D. Lindor). 26 Vascular Diseases of the Liver (Bashar A. Aqel). 27 Hepatic Complications of Bone Marrow Transplantation (Kelly K. Curtis, James L. Slack, Hugo E. Vargas). 28 Hepatic Manifestations of Systemic Diseases (Stephen Crane Hauser). Part 6: Liver Transplantation. 29 Indications and Patient Selection (Saleh Alqahtani, Kymberly D.S. Watt). 30 What Hepatologists Should Know About Liver Transplant Surgery (Kristin L. Mekeel, David C. Mulligan). 31 Immunosuppression: The Essentials (David J. Post, David D. Douglas). 32 Liver Transplantation: Early and Long Term Management and Complications (Chakri Panjala, Denise M. Harnois). Part 7: Problem-Based Approach to Biliary Tract Disease and Gallbladder. 33 Gallstones, Gallbladder Polyps and Their Complications: Epidemiology, Pathogenesis, Diagnosis and Management (Ethan D. Miller, M. Edwyn Harrison). 34 Functional Gallbladder and Sphincter of Oddi Disorders (Bret T. Petersen). 35 Cancer of the Gallbladder and Biliary Tree (David J. Rea, David M. Nagorney, Charles B. Rosen). 36 Biliary Strictures and Leaks (Erin W. Thackeray, William Sanchez). Index.

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