Epidemiology and Medical statistics Books

Book SynopsisLongitudinal Structural Equation Modeling is a comprehensive resource that reviews structural equation modeling (SEM) strategies for longitudinal data to help readers determine which modeling options are available for which hypotheses. This accessibly written book explores a range of models, from basic to sophisticated, including the statistical and conceptual underpinnings that are the building blocks of the analyses. By exploring connections between models, it demonstrates how SEM is related to other longitudinal data techniques and shows when to choose one analysis over another. Newsom emphasizes concepts and practical guidance for applied research rather than focusing on mathematical proofs, and new terms are highlighted and defined in the glossary. Figures are included for every model along with detailed discussions of model specification and implementation issues and each chapter also includes examples of each model type, descriptions of model extensions, commeTrade Review"This is a "must have" volume on examining change from a SEM perspective. It is thoughtfully put together beginning with a number of basic principles/concepts in the latent variable approach to change (e.g., longitudinal measurement invariance, linear and nonlinear growth). It then moves into a number of intermediate approaches (cross-lagged panel models, latent class, latent transition, and latent growth mixture models). The final chapters provide more advanced topics (time series and dynamic structural equation models, survival analysis, and missing data). The various topics covered are extensive, clearly presented, and well supported with examples and references that readers can use to work through the analyses."Ronald H. Heck, University of Hawaii"This book offers a schematic, comprehensive, and well-structured resource for understanding, applying, and teaching most of the techniques related to Longitudinal SEM. The book follows a specific flow based on the difficulties of the topics. It starts with a clear introduction to latent variable modeling, then moves on widely used longitudinal applications (e.g., measurement invariance, cross-lagged panel models), and finally offers chapters on more advanced and recent topics (e.g., LST, Mixture Modeling, and DSEM). The structure of the book also allows the reader to directly access the topics of interest. Both from an applied and teaching perspective, it is difficult to think of a more complete and better structured book on longitudinal SEM."Enrico Perinelli, University of Trento (Italy)"I've cited Jason Newsom's first edition of Longitudinal Structural Equation Modeling many times, and his second edition continues the tradition of clear, accessible presentations that cover both the basics of analysis and modeling strategies for longitudinal data and extra details that experts would appreciate. An impressive, authoritative work."Rex Kline, Concordia UniversityTable of ContentsContentsList of FiguresList of TablesPreface to the Second EditonPreface to the First EditionAcknowledgementsExample Data SetsChapter 1. Review of Some Key Latent Variable PrinciplesChapter 2. Longitudinal Measurement InvarianceChapter 3. Structural Models for Comparing Dependent Means and Proportions Chapter 4. Fundamental Concepts of Stability and Change Chapter 5. Cross-Lagged Panel ModelsChapter 6. Latent State-Trait ModelsChapter 7. Linear Latent Growth Curve Models Chapter 8. Nonlinear Latent Growth Curve ModelsChapter 9. Nonlinear Latent Growth Curve ModelsChapter 10. Latent Class and Latent TransitionChapter 11. Growth Mixture Models Chapter 12. Intensive Longitudinal Models: Time Series and Dynamic Structural Equation Models Chapter 13. Survival Analysis Models Chapter 14. Missing Data and Attrition Appendix A: Notation Appendix B: Why Does the Single Occasion Scaling Constraint Approach Work? Appendix C: A Primer on the Calculus of ChangeGlossaryIndex

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Book SynopsisModelling Survival Data in Medical Research, Fourth Edition, describes the analysis of survival data, illustrated using a wide range of examples from biomedical research. Written in a non-technical style, it concentrates on how the techniques are used in practice. Starting with standard methods for summarising survival data, Cox regression and parametric modelling, the book covers many more advanced techniques, including interval-censoring, frailty modelling, competing risks, analysis of multiple events, and dependent censoring.This new edition contains chapters on Bayesian survival analysis and use of the R software. Earlier chapters have been extensively revised and expanded to add new material on several topics. These include methods for assessing the predictive ability of a model, joint models for longitudinal and survival data, and modern methods for the analysis of interval-censored survival data.Features:Presents an accessible account oTable of Contents1. Survival analysis 2. Some non-parametric procedures 3. The Cox regression model 4. Model checking in the Cox regression model 5. Parametric regression models 6. Flexible parametric models 7. Model checking in parametric models 8. Time-dependent variables 9. Interval-censored survival data 10. Frailty models 11. Non-proportional hazards and institutional comparisons 12 Competing risks 13. Multiple events and event history modelling 14. Dependent censoring 15. Sample size requirements for a survival study 16. Bayesian survival analysis 17. Survival Analysis with R

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Book SynopsisWith the revolution in information technology, concerns about the proliferation of false, unverified, and misleading information have been growing. As one of the severe public health crises in modern history, the COVID-19 pandemic has provided a novel context for the post-truth research. In a post-truth era, people are no longer interested in investigating objective facts, but tend to curl up in echo chambers and resonate with like-minded others. Against this backdrop, this book (1) systematically conceptualises post-truth and analyzes its defining characteristics and driving forces, (2) examines the nuanced effects of information sources and news consumption behaviours and strategies on COVID-19 misperceptions and knowledge, (3) explores the role of social media in shaping COVID-19-related misperceptions and knowledge, and (4) highlights the importance of news media literacy in navigating the post-truth era.The book will be essential reading for students and scholars of mediTable of Contents1. Conceptualizing the “Post-truth” 2. Information Sources and News Consumption Habitus 3. Social Media as a Pandora’s Box 4. News Media Literacy as a Silver Lining 5. Concluding Remarks

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Book SynopsisThis important book examines how nursing homes experienced the COVID-19 pandemic, how it affected the residents and staff, and how the industry can be reformed to better meet the demands of a similar health crisis in the future.Data-led and richly illustrated with insightful charts throughout, the book begins with a thorough overview of what occurred in nursing homes during the pandemic, situated within a broader perspective of the regulatory system in which long-term care operates in different regions of the world. It then moves on to detail those issues that made managing nursing homes during the pandemic so challenging, before providing an insightful analysis into how nursing homes can reform their policies and practices ahead of a possible future pandemic.Written by a gerontological nurse and Director of Nursing with over 30 years of experience in the long-term care industry, this book will interest researchers and practitioners across public health and n

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisThis guide to statistics for busy mental health professionals describes and applies concepts without mathematics, and includes examples from standard clinical practice. Fully revised and updated in a new edition and covering observational bias, randomization, clinical trials, the overuse of p-values, understanding effect sizes, meta-analysis.Table of Contents1. Why data never speak for themselves; 2. Why you cannot believe your eyes; 3. Levels of evidence; 4. Bias; 5. Randomization; 6. Clinical trials: improving on clinical experience; 7. The p-value: uses and misuses; 8. Forget p-values: the importance of effect sizes; 9. Understanding placebo; 10. Understanding confidence intervals; 11. Observational studies; 12. The alchemy of meta-analysis; 13. Bayesian statistics: why your opinion counts; 14. Causation; 15. A philosophy of statistics; 16. Evidence-based medicine: defense and criticism; 17. Social and economic factors: peer review, funding, and the conventional wisdom; 18. The new canon of psychopharmacology (STAR*D, STEP-BD, CATIE): how clinical trials are misinterpreted; 19. False positive maintenance clinical trials in psychiatry; 20. How to analyze a study; Appendix. Understanding regression; Index.

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Book SynopsisDo you want to know what a parametric test is and when not to perform one? Do you get confused between odds ratios and relative risks? Want to understand the difference between sensitivity and specificity? Would like to find out what the fuss is about Bayes'' theorem? Then this book is for you! Physicians need to understand the principles behind medical statistics. They don''t need to learn the formula. The software knows it already! This book explains the fundamental concepts of medical statistics so that the learner will become confident in performing the most commonly used statistical tests. Each chapter is rich in anecdotes, illustrations, questions, and answers. Not enough? There is more material online with links to free statistical software, webpages, multimedia content, a practice dataset to get hands-on with data analysis, and a Single Best Answer questionnaire for the exam.Trade Review'An accessible book by a practising doctor, aimed at other doctors, which explains key statistical concepts in words and pictures. An excellent foundation for those seeking to understand the numbers in medical journal articles and quantitative reports.' Professor Trish Greenhalgh, University of Oxford, UK'Statistics forms the starting point for evidence based medicine, though most medics would argue that their own statistical awareness is still near the starting point! This book eases you into the awesome, exciting, exhilarating world of statistics, and makes you understand just how cool it really is. It will unleash your inner statistician that no-one knew existed - especially you!' Professor Dan Perry, Children's Orthopaedic Surgeon and Fellow of Wolfson College, University of Oxford, UK'The book provides a light-hearted introduction to the basic concepts in medical statistics. A couple of hundred pages long with short chapters, the book delivers with clear focus the key statistical concepts alongside some general knowledge to lighten what is sometimes a very arid subject. The description of concepts with graphs and figures support the visual learner. I thoroughly enjoyed the quick questions presented alongside the description of concepts to test understanding, with the answers at the end of chapter which linked to bullet point summaries, help to consolidate the concepts covered. I thought it was an excellent way for someone to start on their path to understanding this area. Finally, I particularly appreciated the last chapter with its focus on the work by our dear friend Doug Altman.' Professor Rafael Perera, Professor of Medical Statistics, University of Oxford, UK'This is an excellent introductory book for medical statistics. It's well written, easy to read, with some great examples of statistics in everyday clinical practice. The question and answer format is especially useful in reinforcing key concepts discussed in the chapter. There are lots of additional learning material included in the online resource for those seeking a more detailed understanding of the topic. The author is to be congratulated on making an important but difficult subject appear relatively straightforward and interesting to even the non-expert.' Professor Paul Banaszkiewicz, Consultant Orthopaedic Surgeon North East NHS Surgical Centre (NENSC), Gateshead, UK, and Visiting Professor Northumbria University, Newcastle-upon-Tyne, UK 'The modern practice in orthopaedic and trauma surgery is a completely different practice to that which many of us grew up with and is now firmly founded on research and evidence. And this evidence itself is built around scientific method and statistical analysis. This excellent book provides a comprehensive guide to biostatistics for the orthopaedic surgeon and aspiring clinician scientist. Through clear explanations of complex concepts the author succeeds in simplifying the difficult and I am sure this will become an essential reference for all involved in orthopaedic surgery.' Professor Ben Ollivere, Professor of Orthopaedic Trauma, University of Nottingham, UKTable of ContentsPreface; Acknowledgements; How to get the best out of this book; 1. Medicine and numbers: what is the connection?; 2. Measuring a variable: what is the difference between eye colour and height; 3. Summarising data: communicating easily; 4. Why average and range is not always enough: standard deviation and standard error; 5. The normal distribution: what's so 'normal' about it?; 6. Confidence interval: what is your guesstimate?; 7. Innocent until proven guilty! The null hypothesis; 8. Errors in hypothesis tests: learn your α from your β; 9. The randomized controlled trial: why does it have to be random?; 10. Choosing a statistical test: to t or not to t?; 11. Finding the odd one out: the ANOVA test; 12. Categorically different? The Chi-Squared test; 13. If the line fits: correlation and linear regression; 14. Hindsight is 20/20: logistic regression; 15. Don't risk the odds. risk vs odds as the outcome measure; 16. I will survive! Time to event data analysis; 17. High-ceiling or low threshold? Accuracy of a diagnostic test; 18. Apples or oranges? Meta-analysis of selected studies; 19. Lies, damned lies and statistics: untangling facts from fiction!; Glossary; Appendix 1. Are you ready to test yourself? Single Best Answer questionnaire; Appendix 2. Software and practice problems; Appendix 3. Practice database; Appendix 4. References and further reading; Appendix 5. Further resources.

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Book SynopsisTranslating the evidence from the bedside to populations This sixth edition of the best-selling Epidemiology, Evidence-based Medicine and Public Health Lecture Notes equips students and health professionals with the basic tools required to learn, practice and teach epidemiology and health prevention in a contemporary setting. The first section, Epidemiology', introduces the fundamental principles and scientific basis behind work to improve the health of populations, including a new chapter on genetic epidemiology. Applying the current and best scientific evidence to treatment at both individual and population level is intrinsically linked to epidemiology and public health, and has been introduced in a brand new second section: Evidence-based Medicine' (EBM), with advice on how to incorporate EBM principles into your own practice. The third section, ''Public Health'', introduces students to public health practice, including strategies anTrade ReviewThis introductory overview for pre-med and medical students, public health students, and junior doctorssets out key concepts, processes, measurements, and types of studies in epidemiology, and outlinesmajor elements of evidence-based medicine, with chapters on diagnosis, prognosis, effectiveness,systematic reviews and meta-analysis, health economics, and research ethics. Final chapters on publichealth discuss healthcare inequalities. This sixth edition contains new chapters on genetic epidemiologyand on global health and climate change, along with new global case studies. The reader-friendly colorlayout features objectives, boxes, checklists, key points, charts, and process illustrations. Otherlearning features include a glossary and in-depth case quizzes with explained answers. Each chapterends with further reading and a list of web sites. Editor Ben-Schlomo teaches clinical epidemiology atthe University of Bristol, UK. (Book News, June 2013)Table of ContentsPreface, vi List of contributors, viii Part 1 Epidemiology 1 Epidemiology: defining disease and normality, 3 Sara T. Brookes and Yoav Ben-Shlomo 2 Measuring and summarising data, 11 Sara T. Brookes and Yoav Ben-Shlomo 3 Epidemiological concepts, 20 Sara T. Brookes and Yoav Ben-Shlomo 4 Statistical inference, confidence intervals and P-values, 26 Kate Tilling, Sara T. Brookes and Jonathan A.C. Sterne 5 Observational studies, 36 Mona Jeffreys and Yoav Ben-Shlomo 6 Genetic epidemiology, 46 David M. Evans and Ian N.M. Day 7 Investigating causes of disease, 55 Debbie A. Lawlor and John Macleod Self-assessment questions – Part 1: Epidemiology, 63 Part 2 Evidence-based Medicine 8 An overview of evidence-based medicine, 69 Yoav Ben-Shlomo andMatthew Hickman 9 Diagnosis, 74 Penny Whiting and Richard M.Martin 10 Prognosis, 84 Yoav Ben-Shlomo andMatthew Hickman 11 Effectiveness, 92 Sara T. Brookes and Jenny Donovan 12 Systematic reviews and meta-analysis, 102 Penny Whiting and Jonathan Sterne 13 Health economics, 112 William Hollingworth and Sian Noble 14 Audit, research ethics and research governance, 120 Joanne Simon and Yoav Ben-Shlomo Self-assessment questions – Part 2: Evidence-based medicine, 128 Part 3 Public Health 15 Public health, 135 Matthew Hickman, Ruth Kipping and David Gunnell 16 Screening, 145 Angela E. Raffle 17 Infectious disease epidemiology and surveillance, 152 Caroline Trotter, Isabel Oliver and Matthew Hickman 18 Inequalities in health, 160 Bruna Galobardes,Mona Jeffreys, and George Davey Smith 19 Health improvement, 170 Bruce Bolam 20 Evaluating public health and complex interventions, 177 Yoav Ben-Shlomo and Rona Campbell 21 Health care targets, 184 Maya Gobin and Gabriel Scally 22 Global health, 191 Sanjay Kinra, David L. Heymann and Shah Ebrahim Self-assessment questions – Part 3: Public health, 202 Glossary of terms, 205 Self-assessment answers – Part 1: Epidemiology, 221 Self-assessment answers – Part 2: Evidencebased medicine, 224 Self-assessment answers – Part 3: Public health, 228 Index, 233

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Book SynopsisStatistical ideas have been integral to the development of epidemiology and continue to provide the tools needed to interpret epidemiological studies. Although epidemiologists do not need a highly mathematical background in statistical theory to conduct and interpret such studies, they do need more than an encyclopedia of "recipes."Statistics for Epidemiology achieves just the right balance between the two approaches, building an intuitive understanding of the methods most important to practitioners and the skills to use them effectively. It develops the techniques for analyzing simple risk factors and disease data, with step-by-step extensions that include the use of binary regression. It covers the logistic regression model in detail and contrasts it with the Cox model for time-to-incidence data. The author uses a few simple case studies to guide readers from elementary analyses to more complex regression modeling. Following these examples through several chapters makes it easy to compare the interpretations that emerge from varying approaches.Written by one of the top biostatisticians in the field, Statistics for Epidemiology stands apart in its focus on interpretation and in the depth of understanding it provides. It lays the groundwork that all public health professionals, epidemiologists, and biostatisticians need to successfully design, conduct, and analyze epidemiological studies.Trade Review"Jewell's book can certainly be included in any group of useful books on statistics in epidemiology. It actually might be the one with which I would start."-Technometrics, February 2005, Vol. 47, No. 1 "This is a useful and thought-provoking book written by an expert in the field, providing a very valuable supplement to more introductory texts as well as a guide to more advanced sources. "-Journal of the Royal Statistics Society "…It is a good companion text … The numerous worked examples and references to further reading at the end of each chapter are very good … I would find the book a useful reference for the teacher of statistical methods for epidemiology …"-Statistics in Medicine, 2005 "Good points of the book are the exercises, comments and further reading at the end of each chapter, the availability of the data sets used … and the extensive discussion of confounding … this is a good, well-written piece of work."-Pharmaceutical Statistics, 2004 "This book is excellent; a real breakthrough in texts on statistics in epidemiology, especially in its attention to causation and bias." -Sander Greenland, Department of Epidemiology, UCLA"Using examples, this experienced statistician identifies scientific issues and clearly links them to statistical approaches. Statistical theory and formality are grounded in manageable yet realistic examples. Coverage includes the basics and important topics such as measurement error and causal analysis. The book has excellent references, an informative index and glossary."-ISI Short Book Reviews, August 2004Table of ContentsIntroduction. Measures of Disease Occurrence. The Role of Probability on Observational Studies. Measures of Disease-Exposure Association. Study Designs. Assessing Significance in a 2 x 2 Table. Estimation and Inference for Measures of Association. Causal Inference and Extraneous Factors: Confounding and Interaction. Control of Extraneous Factors. Interaction. Exposures at Several Discrete Levels. Regression Models Relating Exposure to Disease. Estimation of Logistic Regression Model Parameters. Confounding and Interaction Within Logistic Regression Mode. Epilogue - the Examples.

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Book SynopsisAn Introduction to Stata for Health Researchers, Fifth Edition updates this classic book that has become a standard reference for health researchers. As with previous editions, readers will learn to work effectively in Stata to perform data management, compute descriptive statistics, create meaningful graphs, fit regression models, and perform survival analysis. The fifth edition adds examples of performing power, precision, and sample-size analysis; working with Unicode characters; managing data with ICD-9 and ICD-10 codes; and creating customized tables.With many worked examples and downloadable datasets, this text is the ideal resource for hands-on learning, whether for students in a statistics course or for researchers in fields such as epidemiology, biostatistics, and public health who are learning to use Stata's tools for health research.Table of ContentsI The basics 1. Getting started 2. Getting help—and more 3. Command syntax II Data management 4. Variables 5. Getting data in and out of Stata 6. Adding explanatory text to data 7. Calculations 8. Commands affecting data structure 9. Taking good care of your data III Analysis 10. Description and simple analysis 11. Regression analysis 12. Time-to-event data 13. Power, precision, and sample-size analysis 14. Measurement and diagnosis 15. Miscellaneous IV Graphs 16. Graphs V Advanced topics 17. Advanced topics

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Book SynopsisIn 2014, a 28-year old British doctor found himself co-running the Ebola isolation unit in Sierra Leone’s main hospital after the doctor in charge had been killed by the virus. Completely overwhelmed and wrapped in stifling protective suits, he and his team took it in turns to provide care to patients while removing dead bodies from the ward. Against all odds he battled to keep the hospital open, as the queue of sick and dying patients grew every day. Only a few miles down the road the Irish Ambassador and Head of Irish Aid worked relentlessly to rapidly scale up the international response. At a time when entire districts had been quarantined, she travelled around the country, and met with UN agencies, the President and senior ministers so as to be better placed in alerting the world to the catastrophe unfolding in front of her. In this blow-by-blow account, Walsh and Johnson expose the often shocking shortcomings of the humanitarian response to the outbreak, both locally and internationally, and call our attention to the immense courage of those who put their lives on the line every day to contain the disease. Theirs is the definitive account of the fight against an epidemic that shook the world.Trade ReviewGetting to Zero is a compelling read, full of compassion, grief, ingenuity and stories of courage and unstinting commitment of local nurses, cleaners and others who remain unsung heroes of Ebola. But it is also full of tales of denial, extraordinary lapses in leadership and awkward truths that will make uncomfortable reading for many, locally and internationally. * Guardian *Written in an honest and engaging tone, their experience behind the scenes of the outbreak is illuminating and highlights important lessons for the management of future outbreaks, and the operational errors that increased the number of lives lost in the west African outbreak of 2014–16. * Lancet *Hundreds of reports have been written on the 2014 epidemic – the most widespread Ebola outbreak since the virus was discovered – but none is nearly as insightful, compassionate or unsparing as this. * Irish Times *A brave, bold, yet humble account from the frontlines of the Ebola outbreak in Sierra Leone. This is vital reading to help us all do better next time. * David Miliband, President and CEO of the International Rescue Committee *Courage in extreme clinical danger, courage to challenge obstructive bureaucracy, courage to make tough decisions and the courage to endure. This is the courage that Sinead Walsh and Oliver Johnson displayed in Sierra Leone. Their compelling book is essential reading for all who care about global health. * Eldryd Parry, founder of the Tropical Health and Education Trust *A captivating and brutally honest account of the Ebola epidemic from two brave, committed individuals who unexpectedly found themselves at its epicentre. The authors pull no punches, and leave us asking: will these lessons be learned, or will the world once again forget and move on? * Jeremy Farrar, Director of the Wellcome Trust *This powerful book asks important questions about aid and development and offers insights that everyone working in global health should absorb – as well as being a personal and very moving account of an epidemic that killed thousands. * Lord Nigel Crisp, Co-Chair of the All Party Parliamentary Group on Global Health *Walsh and Johnson represent the best of international intervention. This book reveals the complexities and level of cooperation that made “getting to zero” possible. Offers excellent insight into those trying times. * O.B. Sisay, Director of the Situation Room at the National Ebola Response Centre, Sierra Leone *An extraordinary account from the thick of the battle against Ebola. This is history’s first draft, and a powerful example of persistent and pragmatic leadership. Mandatory reading for anyone concerned with global health in the broadest sense. * Paul Farmer, Harvard Medical School, and co-founder of Partners in Health *Takes us behind the scenes to the harrowing frontlines of the Ebola epidemic – highlighting a set of lessons that an inter-connected world would ignore at our peril. A compelling read. * Samantha Power, former US Ambassador to the UN *A detailed, up-close-and-personal perspective on the Ebola epidemic in Sierra Leone, important for all who want to understand what it is to confront a terrible health threat. * Tom Frieden, President and CEO of Resolve to Save Lives, and former Director of the Centers for Disease Control and Prevention *Johnson and Walsh provide a frank, beautifully written, and essential guide to the lessons learned from the heart of the outbreak. Their first-hand experiences in battling this terrible disease will take your breath away. A must read. * Tulip Mazumdar, Global Health Correspondent for BBC News *Table of ContentsMaps Preface 1. New Beginnings: Sierra Leone before the Outbreak of Ebola 2. A Dubious Start: Ebola in Guinea 3. Ebola Emerges in Sierra Leone 4. Kenema Explodes 5. Armageddon 6. The Long Wait for Action 7. The Response Kicks Off 8. The Response Bears Fruit 9. Getting to Zero 10. Conclusion Afterword: If We Had to Do It All Again…

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Book SynopsisA real-life thriller about a nation in crisis, and the controversial decisions its leaders made during the Covid-19 pandemic. First, the government instituted no restrictions. Then, it didn’t order the wearing of face masks. While the rest of the world looked on with incredulity, condemnation, admiration, and even envy, a small country in Northern Europe stood alone. As Covid-19 spread across the globe rapidly, the world shut down. But Sweden remained open. The Swedish Covid-19 strategy was alternately lauded and held up as a cautionary tale by international governments and journalists alike — with all eyes on what has been dubbed ‘The Swedish Experiment’. But what made Sweden take such a different path? In The Herd, journalist Johan Anderberg narrates the improbable story of a small nation that took a startlingly different approach to fighting the virus, guiding the reader through the history of epidemiology and the ticking-clock decisions that pandemic decision-makers were faced with on a daily basis.Trade Review‘One of Sweden’s most popular books about its pandemic.’ -- Derek Scally * The Irish Times *‘In his fine book The Herd, the Swedish journalist Johan Anderberg has chronicled the development of the Swedish policy and how tough it was for its architect, Anders Tegnell, to stay the course as country after country was stampeded into compulsory and comprehensive lockdowns.’ -- Matt Ridley * The Telegraph *‘The Herd is a thrilling read about tight-knit groups of microbiologists and epidemiologists, old grudges, new alliances, and fiery emails … Anderberg is ambitious, knowledgeable, and fearless.’ -- Dagens Nyheter‘The Herd is exemplary journalism of the kind that comes close to the truth through skilled craftsmanship. Anderberg portrays the events in the right order. He relies on relevant facts. He puts the last year in a historical context. He examines without preconceived opinions … Anderberg’s book is like a Corona commission in its own right and a beautiful example of the important role journalism plays in the service of the truth.’ * Barometern *‘Reading Johan Anderberg’s book is not just a way to get perspective and background, detailed descriptions of how the Swedish strategy was formed and what it led to. It is also a way to be released from the debate, both in social and other media. It is extremely cooling. The Herd is no debate book; it is a nuanced report from an incredibly strange time. So strange you need help finding the words to talk about it.’ * Aftonbladet *‘Journalist Johan Anderberg makes a brave effort to tell the story about how Sweden chose its path through the pandemic … Anderberg’s narrative has an effortless ease that manifests itself once the writer has a clear overview, and truly masters his subject without getting sidetracked and stuck on details.’ * Sydsvenskan *‘Anderberg masters to perfection the societal reportage that closely examines the authorities, effortlessly taking us into the meeting rooms and email inboxes where the Swedish Corona strategy took shape. With efficiency and humour, he visualises his protagonists … In a climate where media personalities — myself included — often acted as supporters, critics, and hobby epidemiologists, Anderberg has instead buried himself in facts and tried to paint the overall picture … Questions remain after having finished reading The Herd, but this in no way takes away the honour of having accomplished this impressive pioneering work with such energy and wit from Johan Anderberg. The Herd is sure to greatly impact the debate that we’ve only seen the nascent beginnings of so far.’ * Expressen *‘When the world went into lockdown, Sweden went its own way, and this is the fascinating inside story – superb long journalism.’ * The Sydney Morning Herald *‘A gripping history of Sweden’s Covid response. The people and the power struggles — and how science beat panic.’ -- Fraser Nelson * The Spectator *‘[C]onvincing debut from Swedish journalist Anderberg … Anderberg’s account is peppered with details that add depth to the colourful cast … This is a fascinating addition to the growing body of work on Covid-19.’ * Publishers Weekly *‘A gripping analysis of the Swedish response, which examines how tensions between science, policy and politics heightened as the virus held on. If any book were capable of turning scientific debate into a thriller, this one does so; and for the armchair experts on Covid-19 that many of us have become, it is a must-read.’ -- Frieda Klotz * Sunday Independent *

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Book SynopsisThis book will help you to understand and appraise clinical research articles and guidelines and assess how they should influence your practice. Assuming no prior knowledge, Clinical Evidence Made Easy starts by explaining the theory of evidence-based practice, including: understanding the hierarchy of evidence how to recognize bias assessing research papers making sense of qualitative research making use of clinical guidelines what to do with evidence from pharmaceutical companies how to apply the evidence in real life. The book concludes with a section covering clinical evidence at work (completely updated for this new edition) which: provides you with simple appraisal tools that you can use to evaluate research papers and clinical guidance uses extracts from original journal articles to show how you can put the appraisal tools and theory into practice. This new edition has been thoroughly revised and updated, and now features ‘Test your understanding’ questions for each chapter, along with answers at the end of the book.Table of ContentsUnderstanding clinical evidence 1. The importance of clinical evidence 2. Asking the right questions 3. Looking for evidence 4. Choosing and reading a paper 5. Recognizing bias 6. Statistics that describe 7. Statistics that predict 8. Randomized controlled trials 9. Cohort studies 10. Case–control studies 11. Research on diagnostic tests 12. Qualitative research 13. Research that summarizes other research 14. Clinical guidelines 15. Health economic evidence 16. Evidence from pharmaceutical companies 17. Applying the evidence in real life Clinical evidence at work 18. Asking the right questions 19. Choosing the right statistical test 20. Randomized controlled trials 21. Cohort studies 22. Case–control studies 23. Research on diagnostic tests 24. Qualitative research 25. Research that summarizes other research 26. Clinical guidelines 27. Health economic evidence 28. Evidence from pharmaceutical companies 29. Putting it all together…

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Book SynopsisThis book addresses current topics on pathogenic Vibrio spp. from a comprehensive and holistic perspective. Here, experts in the field provide timely chapters, ranging from genomics, pathogen emergence, and epidemiology to pathogenesis, virulence regulation and host colonization. Questions addressed include: How does climate change affect the spread of these bacteria? What is the status of current vaccines? Are there novel therapeutic options to treat Vibrio infections? Is there likelihood of emergence of new pathogenic strains or species? Can insights from mathematical models and epidemiology lead to prediction of pathogen outbreaks?Recent decades have seen a steady increase in Vibrio spp. infections originating in aquatic and marine habitats, driven by higher human population densities, warming of polluted oceans, natural and human-made disasters, and mass seafood production. These conditions increase the likelihood of pathogenic Vibrio spp. coming into contact with humans, making their study even more timely and relevant as these problems escalate over time. This book is a valuable resource for health management professionals, experienced microbiologists/ microbial ecologists, and early career scientists alike who want to learn more about these important environmental human pathogens. The ideas and technologies presented in this book for preventing, controlling, and monitoring Vibrio spp. infections contribute to the UN Sustainable Development Goal 3: Good Health and Well-Being. Table of ContentsChapter 1. Vibrio Infections and the Twenty-First Century.- Chapter 2. New Insights into Vibrio Cholerae Biofilms from Molecular Biophysics to Microbial Ecology.- Chapter 3. Type VI Secretion Systems: Environmental and Intra-Host Competition of Vibrio cholerae.- Chapter 4. Motility Control as a Possible Link Between Quorum Sensing to Surface Attachment in Vibrio Species.- Chapter 5. The Vibrio Polar Flagellum: Structure and Regulation.- Chapter 6. Environmental Reservoirs of Pathogenic Vibrio Spp. and Their Role in Disease: The List Keeps Expanding.- Chapter 7. Cholera Dynamics and the Emergence of Pandemic Vibrio cholerae.- Chapter 8. Role of Bacteriophages in the Evolution of Pathogenic Vibrios and Lessons for Phage Therapy.- Chapter 9. Vibrio vulnificus, an Underestimated Zoonotic Pathogen.- Chapter 10. The Role of Nutrients and Nutritional Signals in the Pathogenesis of Vibrio cholerae.- Chapter 11. Stress Responses in Pathogenic Vibrios and Their Role in Host and Environmental Survival.- Chapter 12. Vibrio parahaemolyticus Epidemiology and Pathogenesis: Novel Insights on an Emerging Foodborne Pathogen.- Chapter 13. The Viable but Non-Culturable (VBNC) State in Vibrio Species: Why Studying the VBNC State Now, Is More Exciting than Ever.- Chapter 14. Structural Insights into Regulation of Vibrio Virulence Gene Networks.- Chapter 15. When Vibrios Take Flight: A Meta-Analysis of Pathogenic Vibrio Species in Wild and Domestic Birds.- Chapter 16. What Whole Genome Sequencing Has Told Us About Pathogenic Vibrios.

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Book SynopsisThis is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials.This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals.The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives.Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. Trade Review“This book aims to assist investigators in improving the quality of their clinical trials and protocols by discussing fundamental concepts with examples and in-depth review of the literature. … This is a valuable resource for students, clinicians, and researchers who are interested in designing a clinical trial or in critically appraising the published literature on clinical trials.” (Pooja Sethi, Doody’s Book Reviews, December, 2015)Table of ContentsIntroduction to Clinical Trials.- Ethical Issues.- What is the Question?.- Study Population.- Basic Study Design.- The Randomization Process.- Blinding.- Sample Size.- Baseline Assessment.- Recruitment of Study Participants.- Data Collection and Quality Control.- Assessment and Reporting of Harm.- Assessment of Health Related Quality of Life.- Participant Adherence.- Survival Analysis.- Monitoring Committee Structure & Function.- Statistical Methods Used in Interim Monitoring.- Issues in Data Analysis.- Closeout.- Reporting and Interpreting of Results.- Multicenter Trials.- Regulatory Issues.

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Book SynopsisThe COVID-19 global pandemic has triggered health insecurity, food insecurity, and economic insecurity among many others in South Asia. It has profound impact on every sector of human activities ranging from the economic to environment. There is a need for a critical study of the implications of the COVID-19 pandemic for human security in order to fathom the emerging theoretical and policy issues in the region. Hence, the book provides an understanding of the consequences of the COVID-19 global pandemic for human security in South Asia. This intellectually stimulating book provides a critical analysis and insights on this contemporary challenge to policy makers, health professionals, academics, students, researchers, NGO workers working with health, human security and anyone interested in health and human security in South Asia. The book covers major human security areas, i.e. health security, food security, economic security, and environment issue. The role of regional cooperation and global health governance is also covered in the domain of COVID-19. This book fills the existing knowledge gap on the human security in South Asia in general and linking with COVID-19 in particular. From the perspective of policy, the insights of the study would guide the policy makers in South Asia in reframing their security policies emphasising human security issues and challenges. Finally, this book contributes to the evolving debate and discourse on the impact of the COVID-19 on the South Asian region from a human security perspective.

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Book Synopsis'Beautifully written, passionate and moving, this is the book everyone should read about COVID-19' Kate Mosse'Hard to put down' Rachel Clarke'Gripping, humane, eye-opening and seriously tense' Ian DuntThe first book to tell the full story of the COVID-19 pandemic from a doctor on the frontline.ALL ROYALTIES FROM SALES GO TO HEROES, A CHARITY PROTECTING AND SUPPORTING HEALTHCARE WORKERS. On the 8th of February, Dr Dominic Pimenta encountered his first suspected case of coronavirus. Within a week, he began wearing a mask on the tube, and within a month, he moved over to the Intensive Care Unit to help fight the virus.From the initial whispers coming out of China and the collective hesitation to class this as a pandemic to full lockdown and the continued battle to treat whoever came through the doors, Dr Pimenta tells the heroic stories of how the entire system shifted to tackle this outbreak and how, ultimately, the staff managed to save lives.This incredible account captures the shock and surprise, the panic and power of an unprecedented time, and how, at this moment of despair, human generosity and kindness prevailed.'A startlingly personal account ... It can be described as a memoir, a thriller or a horror story, but it is really all at once' Observer'Reads like a thriller – a first-hand account of a group of individuals facing a terrible adversary – but it also moved me sometimes to tears because it communicates the humanity of the patients, as well as the NHS staff. As with all great writing, its honesty shines out' Tim Walker'An excellent book ... Moving and fascinating in equal measure' Xand van TullekenTrade Review'Duty of Care is a tense and gripping account of the unfolding pandemic from a doctor who was there. The bravery and dedication of NHS staff are extraordinary, the looming dangers vividly described. I found it hard to put down' -- Dr Rachel Clarke, Sunday Times bestselling author of Dear Life and Your Life in My Hands.'Gripping, humane, eye-opening and seriously tense. Public interest journalism which reads like a thriller novel' -- Ian Dunt.'Truly wonderful ... Brilliant at explaining what it means to be at the heart of things, the growing sense of menace ... Absolutely essential reading ... It deserves to be on every recommended reading list and pressed into the hands of every politician ... Beautifully written, passionate and moving, this is the book everyone should read about COVID-19' -- Kate Mosse.'A startlingly personal account ... It can be described as a memoir, a thriller or a horror story, but it is really all at once' * Observer. *'Reads like a thriller – a first-hand account of a group of individuals facing a terrible adversary – but it also moved me sometimes to tears because it communicates the humanity of the patients, as well as the NHS staff. As with all great writing, its honesty shines out' -- Tim Walker.'An excellent book ... Moving and fascinating in equal measure' -- Xand van Tulleken.Table of Contents0

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Book SynopsisAn award-winning genetic researcher and a tenacious journalist examine each phase of the Ebola epidemic in West Africa, the largest and deadliest of its kind. Their postmortem identifies factors that kept key information from reaching doctors, complicated the government's response to the crisis, and left responders unprepared for the next outbreak.Trade ReviewA must read for anyone with an interest in disease outbreaks, pandemics, and the international response during an emerging crisis. * Choice *[Sabeti and Pardis] uncover the chaos behind the world’s response to the 2014–2016 Ebola outbreak, and posit how it could have been avoided…Rooted in personal stories and testimonies, the book is a critical, poignant postmortem of the epidemic. -- Erin Blakemore * Washington Post *Puts a human face on the challenges by telling the stories of researchers, clinicians, and patients…The power of Outbreak Culture is its universality. It describes dynamics common at varying levels in every humanitarian emergency…A much-needed call for greater justice next time. -- Nahid Bhadelia * Nature *The authors deftly weave surveys, interviews, and retrospectives on previous outbreaks into a concise depiction of the Ebola epidemic, with particular focus on human behaviors that exacerbated the course of the outbreak. -- William E. Pewen * Science *During epidemics and crises we see the best and worst of humanity. Outbreak Culture provides a thought-provoking account of the behaviors and ensuing politics that transpired throughout the Ebola outbreak of 2014–2016. This book offers important lessons, critically needed, to ensure that we are better prepared for the next epidemic. -- Peter Piot, Director, London School of Hygiene and Tropical MedicineA forceful and instructive account, as passionate and heartfelt as it is learned, Outbreak Culture reveals the experience most Ebola responders had but could not name. Through laboratory data and survey responses from hundreds of individuals directly involved in the world’s largest public health endeavor, Sabeti and Salahi uncover competition, sabotage, fear, blame, and disorganization bordering on chaos, features that are seen in just about any lethal epidemic. -- Paul Farmer, cofounder of Partners in HealthA heroic saga of human nature at its very best and worst. Sabeti and Salahi shed light on the fragmented and uncoordinated global response to the Ebola epidemic. All of us who respond to outbreaks now have a mandatory moral and cultural guide. -- Joseph B. McCormick, coauthor of The Virus Hunters: Dispatches from the FrontlineThis book, written eloquently by a journalist and a scientist, highlights many lessons learned from the Ebola epidemic. The need for transparency, collaboration, and coordination among individual actors and agencies is more important than ever. -- Sylvia Blyden, former Sierra Leone Minister of Social Welfare, Gender and Children’s Affairs

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Book SynopsisWell-heeled American corporations have long had a financial stake in undermining scientific consensus and manufacturing uncertainty. In The Triumph of Doubt, former Obama and Clinton official David Michaels details how corrupt science becomes public policy -- and where it''s happening today. Opioids. Concussions. Obesity. Climate Change.America is a country of everyday crises -- big, long-spanning problems that persist despite their toll on the country''s health. And for every case of government inaction on one of these issues, there is a set of familiar, doubtful refrains: The science is unclear. The data are inconclusive. Regulation is unjustified. It''s a slippery slope.Is it?The Triumph of Doubt traces the ascendance of science-for-hire in American life and government, from its origins in the tobacco industry in the 1950s to its current manifestations across government, public policy, and even professional sports. Amid fraught conversations of alternative facts and truth decay, The Triumph of Doubt wields its unprecedented access to shine a light on the machinations and scope of manipulated science in American society. It is an urgent, revelatory work, one that promises to reorient conversations around science and the public good for the foreseeable future.Trade Review[Michaels] documents not only a shocking disregard for human welfare on the part of big business, but also a co-ordinated effort to compromise the culture of knowledge itself. * Times Literary Supplement *...chock full of good examples that were clearly researched (averaging over 30 references per chapter) and supplemented with Michaels' personal experiences. I think any scientist who wants to bridge the realm of research, policy, politics and ethics would benefit from reading this book. * JULIE POLLOCK, Chemistry World *It is so refreshing to read David Michaels' The Triumph of Doubt. He has the facts researched, vetted and thoroughly cited, and is not afraid to lay blame, call people liars and companies frauds. * San Francisco Review of Books *David Michaels opens our eyes to the methods corporations employ that bend the facts of science in order to make a profit. * Chemistry World *David Michaels is that rare combination: the fearless expert. He not only knows where the bodies are buried, he knows who buried them. The Triumph of Doubt and its predecessor, Doubt Is Their Product, are timely, readable, and essential guides for anyone seeking to understand how the corruption of science is damaging the health of everyone from football players and factory workers to soda drinkers and truck drivers-in short, anyone with a pulse. * Dan Fagin, author of the Pulitzer Prize-winning Toms River *David Michaels lays bare the dark money and the corporate science racket that kept the lethalities of tobacco, asbestos, lead, silica, pesticides, and scores of other life- and health-destroying products on the market and in the workplace, escaping the reach of the law. He names names of people and companies fronted by their so-called 'product defense' business and its corporate attorney enablers; delays, obfuscation, falsehood, and retaliation against ethical whistleblowers are the coins of their insidious realms. This book is written to get you angry enough to want to learn how to defend yourselves, your communities, and our vulnerable planet. Let it grip you toward detection and defiance." * Ralph Nader *As a society, it's vital we properly debate issues using data and research. The Triumph of Doubt, David Michaels's wonderfully deep dive into the well-funded war on scientific consensus and certainty, makes the stakes clear: our planet. Read this." * Adam Savage, Mythbusters *No one has done more to expose the deep corruption in American safety regulation that harms us all-and especially our kids. After spending seven years as America's chief safety regulator, David Michaels offers a beautifully crafted argument for how much more we need to do. Required-if frightening-reading for anyone who cares about a clean and safe environment for America and the world." * Lawrence Lessig, author of Fidelity and Constraint *A page-turner-one you'll wish was fiction. From hired guns to dark money, The Triumph of Doubt unravels corporations' playbook for deceiving the public through misinformation.^ * Mona Hanna-Attisha, author of What the Eyes Don't See *The Triumph of Doubt is an industry-by-industry account of how corporations manipulate science and scientists to promote profits, not public health. Nothing less than democracy is at stake here, and we all should be responding right away to David Michaels' call for action. * Marion Nestle, author of Unsavory Truth *It takes real courage to speak out against entrenched corporate interests and big industry. I saw that courage firsthand when I worked alongside Dr. Michaels in the Obama administration to protect workers at construction sites from cancer-causing silica dust. The Triumph of Doubt doesn't just tell the story of how we overcame the falsehoods of industry-funded studies, it shines a disinfecting light on the ways corporations obscure the truth and downplay risk to pump up their bottom line. This is a must-read." * Tom Perez, former U.S. Labor Secretary *A compelling and necessary work for anyone interested in the truth and those who seek to bury it. Michaels details the methods used by those in power to hide the truth-and the moral bankruptcy at work when they do so." * Demaurice Smith, National Football League Players Association Executive Director *As a third-generation coal miner from a family who has suffered the deadly consequences of Black Lung, I know firsthand that worker safety should never be politicized. David Michaels's book is a must-read for business, labor and the scientific community." * Richard Trumka, AFL-CIO President *David Michaels provides well-written evidence in his book about how corporations that produce dangerous products-tobacco, big oil, chemicals, pharmaceuticals-use 'product defense' science to sow doubt about the hazards hidden in their products to consumers. His evidence highlights the important role unbiased government scientists play in protecting the public health of Americans and our environment from exposure to toxic materials and from corporate deceit. * Senator Tom Udall *From the pharmaceutical industry's role in the opioid crisis to the Koch brothers' climate denial apparatus, Michaels examines big industry's jarring history of manufacturing false scientific doubt in the name of profit. This is an important book that will serve as a tool in exposing corporate deceit. * Senator Sheldon Whitehouse *Whether it's the tobacco industry, the pharmaceutical industry, or the fossil fuel industry, vested interests have repeatedly sought to attack and discredit scientific findings that have revealed the public endangerment by their products. David Michaels should know-he's been fighting the good fight for more than a decade to expose the bad actors and bring them to justice. Read this book to learn what we're up against and how to fight back. * Michael E. Mann, author of The Madhouse Effect *Poisoning the well of public debate is the ultimate act of cynicism. As David Michaels makes breathtakingly clear, one industry after another has lied and manipulated in order to make more money, and the rest of us have borne the terrible costs." * Bill McKibben, author of Falter *While the truth can be inconvenient, corporations and government leaders cannot continue to manufacture alternative narratives that place their interests and profits above our humanity; this culture, if left unchallenged, will result in our doom. The Triumph of Doubt reminds us that there can only be one truth." * Bennet Omalu, author of Truth Doesn't Have a Side *Few people have done more to document disinformation about science than David Michaels. His new book is an important addition to the growing literature on doubt, disinformation, and deception. * Naomi Oreskes, author of Merchants of Doubt *In the NFL, team doctors answer to the organization; players joke that it's like Dracula running the blood bank. It's a microcosm of what David Michaels brilliantly illuminates in The Triumph of Doubt: When corporations manipulate science and launch marketing campaigns to sow doubt, they ensure human suffering. Michaels's work is vital reading for everyone to understand these industry tactics. * Chris Borland, former NFL player *Scientist, public servant, and passionate advocate for health and safety, Michaels has written an absorbing sequel to his path-breaking work on manufactured doubt. He documents how powerful corporations have turned 'product defense' into a new political strategy, using dark money to pummel good science and keep dangerous products on the market. A must-read in the fight to restore public trust in regulatory science." * Sheila Jasanoff, Harvard Kennedy School *Driven by scientific interest, The Triumph of Doubt is a measured but passionate argument for protecting the public from harmful substances via federal oversight." * Foreword Reviews *[An] excoriating account of the corporate denial industry... It is a brave and important book, raising the alarm about the systemic corruption of science. * Felicity Lawrence, Nature *A tour de force that examines how frequently, and easily, science has been manipulated to discredit expertise and accountability on issues ranging from obesity and concussions to opioids and climate change. * Science *David Michaels shows that Big Tobacco's well-known denial tactics have not faded into history, but instead have become an integral part of corporate America's standard business practices. * Undark Magazine *A no-holds barred page-turner. In a series of case studies, it names names and describes how powerful players prioritize a requirement of absolute proof over precaution when it comes to exposures' impacts on human health. * Union of Concerned Scientists *[Michaels'] book is a timely, must read indictment of product defense 'science.'" * Pittsburgh Post-Gazette *David Michaels opens our eyes to the methods corporations employ that bend the facts of science in order to make a profit. * Chemistry World *[A] close look at how powerful corporations fund junk science and misinformation campaigns in order to obscure evidence and undercut regulatory efforts." * Vox *The Triumph of Doubt is a carefully researched review of corporate-funded strategies and practices that undermine public health policies of all kinds. And while it sometimes makes one's blood boil, it is still a gripping read. * New Solutions *[An] excoriating account of the corporate denial industry.... It is a brave and important book, raising the alarm about the systemic corruption of science. * Nature *Table of Contents1. Introduction 2. The Science of Deception 3. The Forever Chemical 4. The NFL's Head Doctors 5. A Spirited Denial 6. The Deal with Diesel 7. On Opioids 8. Deadly Dust 9. Working the Refs 10. Volkswagen's Other Bug 11. The Climate Denial Machine 12. Sickeningly Sweet 13. The Party Line 14. Science for Sale 15. Future in Doubt

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Book SynopsisAlthough the spatial dimension of ecosystem dynamics is now widely recognized, the specific mechanisms behind species patterning in space are still poorly understood and the corresponding theoretical framework is underdeveloped. Going beyond the classical Turing scenario of pattern formation, Spatiotemporal Patterns in Ecology and Epidemiology: Theory, Models, and Simulation illustrates how mathematical modeling and numerical simulations can lead to greater understanding of these issues. It takes a unified approach to population dynamics and epidemiology by presenting several ecoepidemiological models where both the basic interspecies interactions of population dynamics and the impact of an infectious disease are explicitly considered.The book first describes relevant phenomena in ecology and epidemiology, provides examples of pattern formation in natural systems, and summarizes existing modeling approaches. The authors then explore nonspatial models of population dynamics and epidemiology. They present the main scenarios of spatial and spatiotemporal pattern formation in deterministic models of population dynamics. The book also addresses the interaction between deterministic and stochastic processes in ecosystem and epidemic dynamics, discusses the corresponding modeling approaches, and examines how noise and stochasticity affect pattern formation. Reviewing the significant progress made in understanding spatiotemporal patterning in ecological and epidemiological systems, this resource shows that mathematical modeling and numerical simulations are effective tools in the study of population ecology and epidemiology.Table of ContentsIntroduction. Models of Temporal Dynamics. Spatiotemporal Dynamics and Pattern Formation: Deterministic Approach. Spatiotemporal Patterns and Noise. References. Index.

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Book SynopsisComputational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading:You will have the basics of R and be able to dive right into specialized uses of R Trade Review'This book provides a basic overview of computational tools developed in R for carrying out data analyses in genomics. It can be a valuable companion for anyone whowants to utilise the computational tools developed within the Bioconductor and R environments for education and research. This book’s main target audience are students of computational biology to get a first look at the diversity of machine learning methods. Thebook will also servewell biomedical researchers needing a guide to packages that can help them with the analysis of data that they encounter in their work.' - Krzysztof Podgórski, International Statistical Review (2021) doi: 10.1111/insr.12453 Table of Contents Introduction to Genomics. 2. Introduction to R for Genomic Data Analysis 3. Statistics for Genomics 4. Exploratory Data Analysis with Unsupervised Machine Learning 5. Predictive Modeling with Supervised Machine Learning 6. Operations on Genomic Intervals and Genome Arithmetic 7. Quality Check, Processing and Alignment of High-throughput Sequencing Reads 8. RNA-seq Analysis 9. ChIP-seq analysis 10. DNA methylation analysis using bisulfite sequencing 11. Multi-omics Analysis.

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Book SynopsisThis book provides a comprehensive overview of the recent developments in clinical decision support systems, precision health, and data science in medicine. The book targets clinical researchers and computational scientists seeking to understand the recent advances of artificial intelligence (AI) in health and medicine. Since AI and its applications are believed to have the potential to revolutionize healthcare and medicine, there is a clear need to explore and investigate the state-of-the-art advancements in the field. This book provides a detailed description of the advancements, challenges, and opportunities of using AI in medical and health applications. Over 10 case studies are included in the book that cover topics related to biomedical image processing, machine learning for healthcare, clinical decision support systems, visualization of high dimensional data, data security and privacy, bioinformatics, and biometrics. The book is intended for clinical researchers and computati

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Book SynopsisMedical Risk Prediction Models: With Ties to Machine Learning is a hands-on book for clinicians, epidemiologists, and professional statisticians who need to make or evaluate a statistical prediction model based on data. The subject of the book is the patientâs individualized probability of a medical event within a given time horizon. Gerds and Kattan describe the mathematical details of making and evaluating a statistical prediction model in a highly pedagogical manner while avoiding mathematical notation. Read this book when you are in doubt about whether a Cox regression model predicts better than a random survival forest.Features: All you need to know to correctly make an online risk calculator from scratch. Discrimination, calibration, and predictive performance with censored data and competing risks. R-code and illustrative examples. InterpreTrade Review"Two of the top researchers in the field of clinical prediction models have produced a highly innovative book that brings a very technical topic to public grasp by throwing out the formulas and just talking straight from the heart of practical experience. While clinicians and medical residents can now learn how to build, diagnose and validate risk models themselves, all public health researchers, old and new, will reap the benefits and enjoyment from reading this book."~Donna Ankerst, Technical University of Munich "Two of the top researchers in the field of clinical prediction models have produced a highly innovative book that brings a very technical topic to public grasp by throwing out the formulas and just talking straight from the heart of practical experience. While clinicians and medical residents can now learn how to build, diagnose and validate risk models themselves, all public health researchers, old and new, will reap the benefits and enjoyment from reading this book."~Donna Ankerst, Technical University of Munich "Overall, the book offers a well-written, complete and illustrative overview of clinical prediction models with clear stances and directions on the modelling methods, choices and strategies. I find this a very welcome and much needed addition to the literature because prediction is the backbone of medical decision-making; few books are dedicated to modelling strategies and artificial intelligence is ascending in medical research. I thereby highly recommend this book for anyone who would be interested in performing predictive modelling for prognostic or diagnostic research." -Evangelos I. Kritsotakis, International Society for Clinical Biostatistics, 72, 2021 Table of Contents Software. 2. I am going to make a prediction model. What do I need to know? 3. Regression model. 4. How should I prepare for modeling? 5. I am ready to build a prediction model. 7. Does my model predict accurately? 7. How do I decide between rival models? 8. Can't the computer just take care of all of this? 9. Things you might have expected in our book.

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Book SynopsisIntelligent Modeling, Prediction, and Diagnosis from Epidemiological Data: COVID-19 and Beyond is a handy treatise to elicit and elaborate possible intelligent mechanisms for modeling, prediction, diagnosis, and early detection of diseases arising from outbreaks of different epidemics with special reference to COVID-19. Starting with a formal introduction of the human immune systems, this book focuses on the epidemiological aspects with due cognizance to modeling, prevention, and diagnosis of epidemics. In addition, it also deals with evolving decisions on post-pandemic socio-economic structure. The book offers a comprehensive coverage of the most essential topics, including: A general overview of pandemics and their outbreak behavior A detailed overview of CI techniques Intelligent modeling, prediction, and diagnostic measures for pandemics Prognostic models Post-pan

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Book SynopsisDisease is an ever-present threat faced by all human societies. Today, this concept has become an influential area of study known as the global burden of disease, which encompasses contemporary health concerns such as the economic costs of disease, the societal impact of illness in developing nations, and infectious diseases resulting from lifestyle exposures. Before we can ease this global burden, it is essential to establish an accurate view of the current status of human health and disease around the world.Addressing key areas that reflect our understanding of disease, The Changing Face of Disease: Implications for Society explores the evolution of disease, the implications for human societies, its ecology, and the current human response. This volume aims to broaden our view of disease at the dawn of the 21st century through topics such as epidemiological transition, mathematical modeling of disease evolution, parasitic disease, urban pollution and illness, and under-nutritTable of ContentsPART 1. HISTORICAL ASPECTS. Emerging Diseases in the Third Epidemiological Transition. Life History Perspectives on Human Disease. The Evolution, Transmission and Geographic Spread of Infectious Diseases in Human Populations: Questions and Models. PART 2. CURRENT CHALLENGES. Genetic Epidemiology of Parasitic Diseases. Urban Pollution, Disease and the Health of Children. Protecting Pregnant Women from Malaria. Interdisciplinary Research on Schitosoma japonicum. Unravelling Gene-Environment Interactions in Type 2 Diabetes. Investigating The 'Hidden' Epidemic: Sexual Behaviour and Representations of HIV / AIDS Amongst Business People and Medical Personnel in Five Central and Eastern European Nations. The Evolution of Disease and the Devolution of Health Care for American Indians. The Public's Health: The Changing Role of Public Health. Human Behaviour and the Changing Pattern of Disease.

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Book SynopsisTake a front row seat with Professor Luke O'Neill on a high-octane year. Luke has become one of the most well-known and trusted voices of Ireland's COVID-19 pandemic. A world-renowned immunologist, he was thrust into the spotlight as we struggled to make sense of a crisis that saw the country grind to a halt. In these compelling diaries, Luke reveals what life was like behind the scenes as he endeavoured to keep calm and trust that the science would save us.Set against a national backdrop of banana-bread baking, TikTok dancing and outdoor bingo, as well as the devastation to life and livelihood suffered by many, Luke's lockdown diaries reveal the highs and lows of work at the cutting edge of science in his Trinity College lab along with how he coped personally with the pressures of public life.Shot through with the natural positivity and humour that have made Luke a home-grown hero, Keep Calm and Trust the Science is an unputdownable account of one of the most

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Book SynopsisPublished by Sinauer Associates, an imprint of Oxford University Press. Increasingly, scientists find themselves facing exponentially larger data sets and analyses without suitable tools to deal with them. Many biologists end up using spreadsheet programs for most of their data-processing tasks and spend hours clicking around or copying and pasting, and then repeating the process for other data files.Practical Computing for Biologists shows you how to use many freely available computing tools to work more powerfully and effectively. The book was born out of the authors'' own experience in developing tools for their research and helping other biologists with their computational problems. Although many of the techniques are relevant to molecular bioinformatics, the motivation for the book is much broader, focusing on topics and techniques that are applicable to a range of scientific endeavors. Twenty-two chapters organized into six parts address these topics (and more; see Contents): * Trade ReviewPractical Computing for Biologists is a clear guide to methods that unlock the power of the personal computer. Although the breadth of subjects covered is certainly an asset of this volume, what really makes the book stand out is how well the authors clearly describe each technique and its applicability to biological sciences. It is a great launching point for any necessary further investigation of computational techniques. * Matthew Aiello-Lammens, The Quarterly Review of Biology *The book covers a wide range of subjects that truly justifies the title of 'practical computing.' In addition to the usual programming-related topics, it also includes a thorough introduction to the programming environment, approaches to combining different programs together, a description of the basic text manipulation tools such as regular expressions, and even an introduction to dealing with digital art and images. As such the book is great value for the money, being at least three books in one. * Olga G. Troyanskaya, Cell *My copy of Practical Computing for Biologists arrived last week, and I've been very impressed. It is a well-written, well-paced guide to basic computing skills for scientists and engineers of all stripes (not just biologists). It is beautifully produced: full-color printing and great graphical design make this book a joy to read. If I ever do turn Software Carpentry into a book, I might skip the topics PCB covers and just tell people to go and buy it. * Greg Wilson, software-carpentry.org *When considering my research and use of time, this book has been the most important book I've read in the last year, and perhaps the last decade. Striking a perfect balance by guiding you through tutorials and nudging your own self-exploration, the book has just enough guided direction to not annoy or overwhelm. It has helped (and is still helping) me to do what I was doing before, but more efficiently. * Cyme & Cystidium *Table of ContentsBefore You Begin.- PART I: TEXT FILES.- Getting Set Up.- Regular Expressions: Powerful Search & Replace.- Exploring the Flexibility of Regular Expressions.- PART II: THE SHELL.- Command-line Operations: The Shell.- Handling Text in the Shell.- Scripting with the Shell.- PART III: PROGRAMMING.- Components of Programming.- Beginning Python Programming.- Decisions and Loops.- Reading and Writing Files.- Merging Files.- Modules and Libraries.- Debugging Strategies.- PART IV: COMBINING METHODS.- Selecting and Combining Tools.- Relational Databases.- Advanced Shell and Pipelines.- PART V: GRAPHICS.- Graphical Concepts.- Working with Vector Art.- Working with Pixel Images.- PART VI: ADVANCED TOPICS.- Working on Remote Computers.- Installing Software.- Electronics: Interacting with the Physical World.- APPENDICES.- Working with other Operating Systems.- Regular Expression Search Terms.- Shell Commands.- Python Quick Reference.- Template Programs.- Binary, Hex, and ASCII.- SQL Commands.- Index.

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Book SynopsisSince the identification of the first cases of the coronavirus in December 2019, there has been a significant amount of confusion regarding the origin and spread of the so-called ''coronavirus'', SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the virus, unproven therapies, and inconsistent public health measures, have all served to increase anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? In this concise and accessible introduction, a leading expert provides answers to these commonly asked questions. This revised and updated edition now also covers how the virus mutates, how important these mutations are, how vaccines work, and what we can expect in the near and long-term future.Trade Review'With all the technology and medical knowledge of the 21st century a pandemic virus has defeated us. This book tells us why and how that could happen and what we can do about it. And as a bonus we get a comparison with the 1918 pandemic Flu. All this wrapped up in a clear, understandable and interesting way. We learn what is happening to us now and how to better prepare for the future.' Arnold J. Levine, Institute for Advanced Study, Princeton, New Jersey'An extremely concise and important book that everyone should read to understand the dynamics of the COVID-19 pandemic.' Siddhartha Mukherjee, Columbia University, New York, and author of The Gene and The Emperor of All Maladies'Raul Rabadan has written an essential book for the first pandemic of the 21st century, COVID19 caused by SARS-CoV-2. It's a wonderfully concise and accessible explanation of everything you want to know about the virus, the disease, and the outbreak. If you want to learn what is a coronavirus, how the outbreak started, what are the therapeutic options, and much more, I highly recommend this book. Professor Rabadan explains viruses in a way that is accessible to all.' Vincent Racaniello, Columbia University, New York'A much-needed primer that offers basic information … What Understanding Coronavirus does very well is clarify virology and epidemiology basics. Asking how quickly the virus spreads means explaining the basic reproduction number R0 and concepts such as 'flattening the curve' and herd immunity that everyone has been confronted with. It explains the symptoms, the typical course of the disease, how deadly it is, and that, yes, children and young adults get infected too, but their symptoms are usually less severe … Understanding Coronavirus overall provides a lot of relevant information in a very readable and concise format. And at this price, you cannot really go wrong.' Leon Vlieger, Natural History Book Service'A clear scientific guide to COVID-19 ... (it) illuminates coronavirus science not only with clear writing but also with good graphics and illustrations.' Clive Cookson, Financial Times'This small book could be required reading for many politicians and journalists …' Tilli Tansey, Nature'Another great value of this small book is the citation of the original research papers Rabadan used. I highly recommend this volume for biology students, teachers, and college professors. The publication presents the main concepts and facts needed to understand the COVID-19 pandemic clearly and concisely.' Monica Trujillo, The Quarterly Review of Biology'Following this slim, concise, accessible, recently updated, and nicely illustrated introduction to the coronavirus may take some effort, but readers are sure to find it well worthwhile … The book concludes with the author's comments on diagnosis, prevention, and treatment of COVID-19 and the role vaccines and the immune system play in confronting this virus … Essential.' S. W. Moss, Choice ConnectTable of ContentsPreface; 1. Introduction; 2. How Is the Coronavirus Spreading?; 3. What Is a Coronavirus?; 4. How Is the Coronavirus Changing?; 5. How Did the COVID-19 Outbreak Start and Evolve?; 6. How Does the COVID-19 Outbreak Compare to the SARS Outbreak in 2003?; 7. How Does the COVID-19 Outbreak Compare to Seasonal and Pandemic Influenza?; 8. How Can We Treat the Virus and Prevent Infections?; Conclusions; Summary of Common Misunderstandings; Suggested Further Reading.

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Book SynopsisA fully updated third edition covering the current research and clinical aspects on the interactions between cannabis and mental illness. Extensively expanded to include new chapters on prenatal cannabis exposure, addiction genetics, cannabis withdrawal, and cannabis and sleep. Essential reading for all members of the mental health team.Trade Review'The 3rd edition of this authoritative book is remarkably up-to-date and reflects well the current state of play in both the neuroscience and clinical approaches at the interface between mental health and cannabis. The updated textbook covers the essentials of cannabis and health and, most importantly, policy in an integrated and impressively comprehensive manner. Each chapter includes both important recent publications as well as seminal papers, particularly important given the evolution of information on cannabis and contemporary considerations for public health. The chapters, authored by world renowned experts, are well written and I particularly liked the explicit tables/ boxes. My distinguished colleagues and friends Drs D'Souza, Castle, and Murray are to be congratulated for providing us with this outstanding, authoritative, and remarkably contemporary book on mental health and cannabis.' Peter F. Buckley, M.D., Chancellor, The University of Tennessee Health Science Center, Memphis, TennesseeTable of ContentsPart I. Pharmacology of Cannabis and the Endocannabinoid System: 1. How cannabis works in the brain Ken Mackie; 2. The function of the endocannabinoid system Nathan D. Winters and Sachin Patel; 3. Synthetic cannabinoids Liana Fattore and Matteo Marti; Part II. The Changing Face of Cannabis: 4. The epidemiology of cannabis use and cannabis use disorder Deborah Hasin; 5. Is cannabis becoming more potent? Tom P. Freeman and Sam Craft; 6. Policy implications of the evidence on cannabis use and psychosis Wayne Hall and Louisa Degenhardt; Part III. Cannabis and the Brain: 7. The impact of pubertal exposure to cannabis on the brain: a focus on animal studies Erica Zemberletti and Tiziana Rubino; 8. The impact of cannabis exposure on the adolescent brain: humans studies and translational insights Jacqueline-Marie Ferland, Alexandra Chisholm and Yasmin L. Hurd; 9. Cannabis and cognition: an update on short- and long-term effects Lisa-Marie Greenwood, Valentina Lorenzetti and Nadia Solowij; 10. Is there a cannabis-associated psychosis subtype? Lessons from biological typing in the b-snip project, and implications for treatment Godfrey Pearlson and Matcheri S. Keshavan; Part IV. Cannabis, Anxiety and Mood: 11. Cannabis and anxiety Grace Lethbridge, Beth Patterson and Michael Van Ameringen; 12. Cannabis consumption and risk of depression and suicidal behaviour Gabriella Gobbi; 13. Cannabis and bipolar disorder Jairo Pinto and Mauren Leticia Ziak; Part V. Cannabis and Psychosis: 14. Cannabis and psychosis proneness Rajiv Radhakrishnan, Shubham Kamal, Sinan Guloksuz and Jim van Os; 15. Which cannabis users develop psychosis? Edoardo Spinazzola, Marta Di Forti and Robin M. Murray; 16. Cannabis causes positive, negative, cognitive symptoms and produces impairments in electrophysiological indices of information processing Ashley Martin-Schnakenberg, Mohini Ranganathan and D. Cyril D'Souza; Part VI. Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications: 17. Does cannabis cause schizophrenia? Emmet Power, Colm Healy, Robin M. Murray and Mary Cannon; 18. Postmortem studies of the brain cannabinoid system in schizophrenia Suresh Sundram, Brian Dean and David Copolov; 19. The endocannabinoid system in schizophrenia Paul Morrison; 20. Cannabidiol as a potential antipsychotic F. Markus Leweke and Cathrin Rohleder; 21. Genetic explanations for the association between cannabis and schizophrenia Sarah M. Colbert and Emma Johnson; Part VII. Cannabis and its Impact on Schizophrenia: 22. Acute effects of cannabinoids in people with a psychotic illness Suhas Ganesh, Cécile Henquet, R. Andrew Sewell, Rebecca Kuepper, Mohini Ranganathan and Deepak Cyril D'Souza; 23. Cannabis and the long-term course of schizophrenia Tabea SchoeleR; 24. Treating cannabis use in schizophrenia and other psychotic disorders Alexandria S. Coles, Ashley E Kivlichian, David J. Castle and Tony P. George; Part VIII. Special Topics: 25. Prenatal cannabis exposure: associations with development and behavior Sarah E. Paul, Cynthia E. Rogers and Ryan Bogdan; 26. Cannabis use and violence Giulia Trotta, Paolo Marino, Victoria Rodriguez, Robin M. Murray and Evangelos Vassos; 27. Cannabis withdrawal Jane Metrik and Kayleigh McCarty; 28. Cannabis and addiction Valerie Curran, Will Lawn and Tom P. Freeman; 29. Tobacco use among cannabis users: insights into co-use and why it matters for people with psychosis Rachel A. Rabin, Erin A. McClure and Tony P. George; 30. Cannabis addiction genetics Suhas Ganesh and Arpana Agrawal; 31. Snoozing on pot: cannabis and sleep Patrick D. Skosnik and Toral S. Surti; 32. Cannabinoids as medicines: what the evidence says and what it does not say Marco De Toffol, Elena Dragioti, Andre Ferrer Carvalho, and Marco Solmi.

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Book SynopsisNow in its fourth edition, this book allows for early career occupational hygienists and occupational health and safety professionals or students to develop their basic skills and knowledge to anticipate, recognize, evaluate, and control workplace hazards that can result in injury, illness, impairment, or affect the well-being of workers and members of the community. Principles of Occupational Health and Hygiene: An Introduction, Fourth Edition offers a comprehensive overview of occupational health risks and hazardous environments encountered in a range of industries and organizational settings.This new edition offers information on the current techniques and equipment used in assessing workplace hazards. Methods of assessment are developing at a rapid rate due to the new technologies now available. Featuring new chapters on occupational hygiene statistics and psychosocial hazards and fully updated throughout, leading industry professionals and educators explain how to

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Book SynopsisThis book provides a practical, application-driven guide to using R for public health and health data science, accessible to both beginners and those with some coding experience. Each module starts with data as the driver of analysis before introducing and breaking down the programming concepts needed to tackle the analysis in a step-by-step manner. This book aims to equip readers by offering a practical and approachable programming guide tailored to those in health-related fields. Going beyond simple R examples, the programming principles and skills developed will give readers the ability to apply R skills to their own research needs. Practical case studies in public health are provided throughout to reinforce learning.Topics include data structures in R, exploratory analysis, distributions, hypothesis testing, regression analysis, and larger scale programming with functions and control flows. The presentation focuses on implementation with R and assumes readers have had an

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Book SynopsisThis book is an introductory guide to programming and coding in Stata. Commonly encountered code in the field of medical statistics as well as the analyses of observational data are presented.For those who are involved in the analyses of observational studies, the need to sometimes assemble large datasets will necessitate a detailed understanding of loops and macros. This book covers these materials early on and then describes other commonly required coding commands.For those who program in a controlled environment (.e.g. medical statisticians who perform analyses for regulatory bodies), the production of log files, a suggested folder structure and analysis pathway are covered. This book also includes a wide range of tabulation commands and other methods of producing tables of descriptive statistics. The text also then provides a clear explanation of how to perform some inferential analyses (including how to extract and format the coefficients for use in subsequent rep

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Book SynopsisTable of ContentsList of Tables xv List of Figures xix Acknowledgements xxv Preface xxvii Preface to the Second Edition xxxv Website xxxvii Part 1: Introduction 1 How a Meta-Analysis Works 3 2 Why Perform a Meta-Analysis 9 Part 2: Effect Size and Precision 3 Overview 17 4 Effect Sizes Based On Means 21 5 Effect Sizes Based On Binary Data (2 × 2 Tables) 33 6 Effect Sizes Based On Correlations 39 7 Converting Among Effect Sizes 43 8 Factors That Affect Precision 49 9 Concluding Remarks 55 Part 3: Fixed-Effect Versus Random-Effects Models 10 Overview 59 11 Fixed-Effect Model 61 12 Random-Effects Model 65 13 Fixed-Effect Versus Random-Effects Models 71 14 Worked Examples (Part 1) 81 Part 4: Heterogeneity 15 Overview 97 16 Identifying and Quantifying Heterogeneity 99 17 Prediction Intervals 119 18 Worked Examples (Part 2) 127 19 An Intuitive Look At Heterogeneity 139 20 Classifying Heterogeneity As Low, Moderate, Or High 155 Part 5: Explaining Heterogeneity 21 Subgroup Analyses 161 22 Meta-Regression 197 23 Notes On Subgroup Analyses and Meta-Regression 213 Part 6: Putting It All In Context 24 Looking At the Whole Picture 223 25 Limitations of the Random-Effects Model 233 26 Knapp–Hartung Adjustment 243 Part 7: Complex Data Structures 27 Overview 253 28 Independent Subgroups Within a Study 255 29 Multiple Outcomes or Time-Points Within A Study 263 30 Multiple Comparisons Within a Study 277 31 Notes On Complex Data Structures 281 Part 8: Other Issues 32 Overview 287 33 Vote Counting – A New Name For An Old Problem 289 34 Power Analysis For Meta-Analysis 295 35 Publication Bias 313 Part 9: Issues Related To Effect Size 36 Overview 335 37 Effect Sizes Rather Than P-Values 337 38 Simpson’s Paradox 343 39 Generality of the Basic Inverse-Variance Method 349 Part 10: Further Methods 40 Overview 361 41 Meta-Analysis Methods Based On Direction and P-Values 363 42 Further Methods For Dichotomous Data 369 43 Psychometric Meta-Analysis 377 Part 11: Meta-Analysis In Context 44 Overview 391 45 When Does It Make Sense To Perform a Meta-Analysis? 393 46 Reporting The Results of a Meta-Analysis 401 47 Cumulative Meta-Analysis 407 48 Criticisms of Meta-Analysis 413 49 Comprehensive Meta-Analysis Software 425 50 How To Explain the Results of An Analysis 443 Part 12: Resources 51 Software For Meta-Analysis 471 52 Web Sites, Societies, Journals, and Books 473 Web sites 473 Professional societies 476 Journals 476 Special issues dedicated to meta-analysis 477 Books on systematic review methods and meta-analysis 477 References 479 Index 491

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Book SynopsisThe pandemic presented religion as a paradox: faith is often crucial for helping people weather life’s troubles and make difficult decisions, but how can religion continue to deliver these benefits and provide societal structure without social contact? The topical volume, An Epidemic among My People explains how the COVID-19 pandemic stress tested American religious communities and created a new politics of religion centered on public health.The editors and contributorsconsider how the virus and government policy affected religion in America. Chapters examine the link between the prosperity gospel and conspiracy theories, the increased purchase of firearms by evangelicals, the politics of challenging public health orders as religious freedom claims, and the reactions of Christian nationalists, racial groups, and female clergy to the pandemic (and pandemic politics). As sharp lines were drawn between people and their governments during this uncertain time, Trade Review“What power does religion hold in times of crisis? Drawing on a wealth of research conducted over the first two years of the coronavirus pandemic, the thoughtful editors and contributors to An Epidemic among My People uncover how faith communities and religious identities shaped responses to the pandemic. At the same time, the broad range of research contained here underscores how a crisis impacts religious beliefs and practices. This unique collection of essays from across the social sciences showcases findings and insights essential to understanding how religious forces matter in our collective experience of major national and worldwide events.”—Janelle Wong, Professor of American Studies and Government and Politics at the University of Maryland, and author of Immigrants, Evangelicals, and Politics in an Era of Demographic Change“COVID-19 had colossal impacts on public health and mortality, with immense social, political, economic, and psychological consequences. Our understanding of its more precise consequences in particular spheres of society remains thin. An Epidemic among My People offers a reliable, in-depth account of the impacts of COVID-19 on one major area of social life—religion. An impressive array of scholars use very strong empirical data to insightfully sort out the many ways religion and the pandemic interacted, and with what consequences. It is essential reading not only on religion, but for anyone wishing to understand the impact of COVID-19 in society generally.”—Christian Smith, Wm. R. Kenan Jr. Professor of Sociology at the University of Notre Dame "The book covers a lot of territory, with unexpected findings throughout....Through its remarkable collection of new research and data analysis, this book provides a broad foundation for scholars to build on to better understand the complex, multifaceted relationship between the Covid-19 pandemic and American religion and politics.”— Politics and Religion

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Book SynopsisThis book presents a unified and up-to-date introduction to ROC methodologies, covering both diagnosis (classification) and prediction. The emphasis is on the conceptual underpinning of ROC analysis and the practical implementation in diverse scientific fields. A plethora of examples accompany the methodologic discussion using standard statistical software such as R and STATA. The book arrives after two decades of intensive growth in both the methods and the applications of ROC analysis and presents a new synthesis. The authors provide a contemporary, integrated exposition of ROC methodology for both classification and prediction and include material on multiple-class ROC. This book avoids lengthy technical exposition and provides code and datasets in each chapter. ROC Analysis for Classification and Prediction in Practice is intended for researchers and graduate students, but will also be useful for those that use ROC analysis in diverse disciplines such as diagnostic medicineTable of Contents1. Introduction 2. Measures of Diagnostic and Predictive Performance 3. Statistical inference for the ROC curve 4. Comparing ROC curves 5. The ROC surface and k-class classification for k > 2 6. ROC regression 7. Missing data and errors-in-variables in ROC analysis

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Book Synopsis"Jim Shepard is a fiction writer of peculiar but tantalizing gifts." The New York TimesIn a tiny settlement on the west coast of Greenland, 11-year-old Aleq and his best friend, frequent trespassers at a mining site exposed to mountains of long-buried and thawing permafrost, carry what they pick up back into their village, and from there Shepard's harrowing and deeply moving story follows Aleq, one of the few survivors of the initial outbreak, through his identification and radical isolation as the likely index patient. While he shoulders both a crushing guilt for what he may have done and the hopes of a world looking for answers, we also meet two Epidemic Intelligence Service investigators dispatched from the CDC--Jeannine, an epidemiologist and daughter of Algerian immigrants, and Danice, an MD and lab wonk. As they attempt to head off the cataclysm, Jeannine--moving from the Greenland hospital overwhelmed with the first patients to a Level 4 high-security facility in the Rocky Mountains--does what she can to sustain Aleq.Both a chamber piece of multiple intimate perspectives and a more omniscient glimpse into the megastructures (political, cultural, and biological) that inform such a disaster, the novel reminds us of the crucial bonds that form in the midst of catastrophe, as a child and several hyper-educated adults learn what it means to provide adequate support for those they love. In the process, they celebrate the precious worlds they might lose, and help to shape others that may survive.Trade ReviewJim Shepard is a fiction writer of peculiar but tantalizing gifts. * The New York Times *If you've been waiting for the great novel of the COVID-19 era, it's in your hands. I read Phase Six with a galloping heart. With heroic humor and a poet's ear and eye for what makes humanity worth saving, Shepard's polyphonic novel of contagion and collapse is also the story of love's unlikely survival in the most hostile conditions -- Karen Russell, author of Swamplandia!Jim Shepard not only writes at the cutting edge of literature, but he IS the cutting edge of literature. He excavates the twin crises of our era-climate change and pathogens-and builds a story that is as poignant as it is true. The writing is stunning. The research is stunning. The after-effect is stunning. Phase Six is a great book for our times: the past, the present and those that-we hope-are yet to come. -- Colum McCann, author of ApeirogonNo amount of prior admiration for Jim Shepard's fiction prepared me for the magnificent Phase Six-a book at once so wise and so funny, so bleak and so tender. With astonishing virtuosity, he conveys huge amounts of information in a way that is not only lucid but utterly gripping, and he creates characters who make me want to rush into the novel to save them from the virus and themselves. What a triumph! -- Margot Livesey, author of The Boy in the FieldImagining catastrophe is, now more than ever, an essential task, and no one does it better than Jim Shepard. At once scary and timely, funny and absorbing, Phase Six is a must-read. -- Elizabeth Kolbert, author of Under a White SkyPaced like a prophetic thriller . . . Shepard has frequently employed research as a foundation for his literary creations, but never before in such pulse-racing fashion . . . Readers will find themselves in territory that feels eerily familiar-panic, politics, uncertainty, fear, a resistance to quarantine, an overload of media noise-as Shepard's command of tone never lets the tension ease . . . All the narrative propulsion of escapist fiction without the escape. * Kirkus Reviews (starred review) *Phase Six is a fast-paced, suspenseful story about what happens when a different microbe is unleashed on the world . . . [A]n ode to family, friends, lovers, hard work and the beautiful, heartbreaking innocence of childhood * Daily Mail *Thrilling . . . a very human story, full of emotion and inevitable sorrow and pain. * Irish Indepedent *

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Book SynopsisThis new volume provides exhaustive knowledge on a wide range of natural products and holistic concepts that have provided promising in the treatment of leishmaniasis. Including the major natural therapies as well as traditional formulations, over 300 medicinal plants and 150 isolated compounds that are reported to have beneficial results in the treatment of the disease are explored in this comprehensive work. This book also acts as an important resource on various anti-inflammatory plants used to treat various inflammatory conditions of the disease.Trade Review"This book fills an important niche and is usefully written in the broadest sense of the subject. The authors are immensely experienced and knowledgeable university teachers. Despite the explosion of online information available with the click of mouse, this is a handy and easy-to-read book that has been carefully conceived and crafted by experts becomes indispensable. I congratulate Dr. Bhatia and Dr. Divakar for bringing out this reference book on leishmaniasis, and I am sure the book will find respectable space in the bookshelves of academicians, busy practitioners, and students alike."—From the Foreword by Professor T. V. Narayana, Secretary, Indian Pharmaceutical Congress Association; Vice President, Indian Pharmaceutical AssociationTable of ContentsAyurveda and Leishmaniasis. Pharmacology of Leishmaniasis. Diagnosis and Strategies to Control Leishmaniasis. Immunomodulatory Agents for Leishmaniasis. Ayurvedic Treatments for Leishmaniasis. Phytotherapy for Leishmaniasis. Elements Supplementation in Leishmaniasis. Alternative Therapies for Leishmaniasis. Inflammation and Leishmaniasis. Modern Treatment for Leishmaniasis.

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