Endocrinology Books

Book SynopsisBone is a dynamic tissue that undergoes continual adaptation during vertebrate life to preserve skeletal size, shape, and structural integrity and to regulate mineral homeostasis. Bone mass is skilfully regulated through osteoclasts and osteoblasts. Bone mass is reduced through decreased osteoblastic bone formation and increased osteoclastic bone resorption. This decrease induces osteoporosis. Bone loss is also caused in various pathophysiologic states including inflammatory condition, obesity, diabetes, and cancer cell bone metastasis. In addition, malnutrition or undernutrition is often observed with increasing ages and is strongly implicated in the pathogenesis and consequences of bone fracture in the osteoporotic elderly. Nutritional and functional food factors may play a pivotal role in maintaining bone health, and this will be expected as a new biomedical treatment for osteoporosis.

Read more less

Book SynopsisEstradiol is the major steroid hormone which is involved in several organic functions, such as physiological sexual behaviour, development and maintenance of male and female reproductive organs, control of visceral secretion, modulation of immune system, and tumorigenesis. In this compilation, the authors discuss the synthesis, health effects and drug interactions of estradiol. Topics include the occurrence of estradiol in environmental waters; estradiol in the central nervous system and its role in neurodegeneration; the effects of estradiol on male and female reproductive tissues and the influence of endocrine disruptors; estradiol and prostate cancer; hydroxyestradiols and methoxyestradiols as endogenous factors associated to physiological and physiopathological conditions; oestrogen and functional gastrointestinal disorders; estradiol and memory; estradiol in the environment; use of combined therapy of estrogens with antidepressants; oestrogen and nitric oxide as a treatment for diabetes gastroparesis; estradiol synthesis after ovarian tissue cryopreservation and transplantation; estradiol-mediated overmodulation of the neuroendocrine hormone dopamine is central to the pathophysiology of restless leg syndrome during pregnancy; and oestrogen modulation on oxidative stress and synaptic plasticity in the dorsal hippocampus.

Read more less

Book SynopsisLeptin was originally described for its role in obesity and energy homeostasis. This book focuses on the biosynthesis, functions and overall clinical significance of leptin. Leptin''s association to Alzheimer''s diseases and other cognitive disorders is discussed along with the leptin-renal axis; the relationship of leptin and melanoma; the inhibition of oncogenic effects of leptin by cAMP elevation in triple negative breast cancer cells; the leptin regulation of intestinal nutrients absorption; the implications of leptin in male reproductive function; the role of leptin in early life metabolism and its physiological, pathological, and potential therapeutic implications; the skeletal effects of leptin; the physiological roles of leptin in oral and maxillofacial region; the respiratory responses to microinjectons of leptin; and leptin as a reproductive modulator.

Read more less

Book SynopsisType 1 diabetes is a chronic auto-immune disease. Type 1 diabetes was previously called insulin-dependent diabetes mellitus (IDDM) or juvenile-onset diabetes. Type 1 diabetes develops when the body''s immune system destroys pancreatic beta cells, the only cells in the body that make the hormone insulin that regulates blood glucose. To survive, people with type 1 diabetes must have insulin delivered by injection or a pump. Topics discussed in this compilation include genetic and epigenetic studies of type 1 diabetes; blood pressure and diabetes during pregnancy; comparison of diseases-specific quality of life, metabolic control and cardiorespiratory fitness in physically active and inactive youths with type 1 diabetes; stem cells for the treatment of patients with type 1 diabetes; and the causes and potential complications of type 1 diabetes.

Read more less

Book SynopsisThis book provides the current knowledge and recent developments to navigate cellular, molecular, and clinical aspects of natriuretic peptides and their receptors in health and disease. State-of-the-art technology in cell and molecular biology has been applied to delineate the expression, function, and regulation of natriuretic peptides and their receptors both in vitro and in vivo model systems. Transgenic and gene-targeted mouse models have clearly demonstrated that the absence of functional natriuretic peptides and/or their cognate receptors cannot only raise blood pressure but also cause severe hypertensive heart, similar to what is seen in untreated human hypertensive patients. The genetically engineered mouse models have been useful to reveal not only the actual functions of the genes for natriuretic peptides and their receptors, but more critically their modifying interactions with other genes. This book presents a comprehensive look at the past developments, current status, and future prospects of the natriuretic peptides and their receptor systems in bedside diagnosis, treatments, and therapeutic advancements. The book comprises of fourteen chapters from eminent scientists in their area of research expertise, and presents a wide range of reviews spanning the research works done on the natriuretic peptides and their receptors. Each chapter provides a comprehensive summary covering the aspects of physiology, molecular biology, and clinical implication of the accomplished experimental findings and future perspectives of research to be performed in this vital and important cardiovascular field. It is expected that this book will provide readers a focused overview of the status and perspectives of the natriuretic peptides and their receptors from the past accomplishments to exciting future investigations.

Read more less

Book SynopsisThe book examines the noradrenaline-emotional psyches (brain-blood barrier) somatic-adrenaline axis. It conceptually updates research advances, diagnostic techniques and therapeutic methods. The authors enhance their discussions with clear illustrations and explicative texts written for researchers, professionals, educators and students alike, which favour its selection as an essential overview of recent medical and scientific advances, allowing the reader to have the satisfaction of finding first-rate accounts of important work. Comparative studies between immediately obtained adrenal vein samples (AVS) and 15 minutes thereafter show that the stress reactions induced by catheter manipulation had an effect on serum cortisol and aldosterone values. A transient increase in cortisol release from both adrenal glands occurs in the majority of the patients who undergo AVS. This stress reaction can influence the assessment of both the selectivity of the catheterisation during the sequential AVS technique and the lateralisation of aldosteronoma bearing gland. The separation of noradrenaline (NA) at brain and adrenaline at blood functions as a homeostatic lame axis by the blood-brain barrier blocking adrenaline feedback in hypothalamic-pituitary-adrenal (HTPA). This leads to postulate an evolution adaptation for the brain dominance over body, which allows a psychoanalytic treatment to function to signal turn-off and return to circadian homeostasis. Decreased glucose could stress the HTPA axis and leads to decreasing metabolites and releasing Mg2+ for integration of the brain-tissue network. Mg2+ changes adenylyl cyclase (AC) from a Ca2+-AC complex to an Mg2+-AC form with responsiveness to NA for short-term memory. The cAMP generated has been postulated for consolidation of long-term memory.

Read more less

Book SynopsisDescriptions of endocrinology will change in the years to come. Endocrinology is not only concerned about the diseases of the known endocrine organs. We know now organs that were not previously recognized as endocrine organs such as the heart and skin are in fact endocrine organs. Endocrinology is a science of knowledge transfer in the human body. Endocrine diseases like diabetes, metabolic syndrome, obesity, polycystic ovary syndrome, hypertension and thyroid disorders are so common in the population. Each exceeds 10% of the total population. Endocrinologic evaluation of whole diseases of emergency situations and critical care situations are important, as well as known endocrine organ diseases in these units. Also, preoperative, perioperative, postoperative evaluation and management of endocrine diseases are very important. This book is the written first edition of a work that may be beneficial for endocrinology and internal medicine residents, surgeons, and medical students. The book purpose is to cover the up-to-date practical endocrine emergencies, perioperative evaluation and endocrine aspects of critical care. If you send us your comments, feedback and chapter headline suggestions, we can make changes in the new edition of this book according to suggestions.

Read more less

Book SynopsisStudies have shown that low quality of life is a risk factor for increased hospitalization, diminished adherence to treatment, and increased morbidity and mortality. Recently, quality of life has been an area of interest in endocrinology. Studies have demonstrated that it is reduced in disturbances such as diabetes mellitus, obesity, thyroid diseases, Cushing''s disease, and pituitary tumors. This book aims at reviewing recently published data on quality of life in endocrine diseases. It presents the available data on quality of life in non-functioning pituitary tumors, prolactinomas, acromegaly, GH deficiency, Cushing''s syndrome, hypo- and hyperthyroidism, hypogonadism, diabetes mellitus, and obesity.

Read more less

Book SynopsisThe human body''s endocrine system includes eight major glands, which make hormones and travel through the bloodstream to tissues or organs. In this book, the authors'' focus on the risk factors, genetics, diagnosis and management of gynecomastia (a benign condition characterized by enlargement of the male breast) and addresses the puzzling controversies surrounding menopausal hormone replacement therapy (HRT) and its health outcomes, which have been the subject of extensive investigation in recent years. The book concludes with a bibliography on recent titles published in the field that readers might find of interest.

Read more less

Book SynopsisDiabetes is a prevalent disorder throughout the world; it has become a universal topic for conversation superseding topics like heart disease or cancer. Self-care and taking responsibility for the illness are integrally important in diabetes so that the patient stays healthy and complications do not develop. Self-care consists of the following: a prescribed diabetes diet, indulging in daily physical activities and taking prescribed doses of insulin. Self-care is promoted through repeated education by doctors and allied health professionals who are knowledgeable in diabetes, pathophysiology and clinical diabetes care. The Handbook of Diabetes for General Practitioners is written for doctors to apprise the fundamentals of diabetes including its recognition as an entity, the discovery of insulin for the treatment of diabetes, pathophysiology of diabetes, and the development and progression of diabetic complications and how to minimize or prevent the complications. Also, several chapters are written to focus on the common flaws in the diagnosis and improper treatment of diabetes. Incorrect diagnosis and treatment of drug-induced hyperglycemia leads to the development of overt diabetes with a range of complications. Diabetic complications are serious, disabling and economically disastrous for healthcare providers. By reading this book, doctors and allied health professionals will be better prepared to deal with the adversities of diabetes to ultimately help their patients live a complication-free life.

Read more less

Book SynopsisThe prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide, and it is becoming a public health concern. In this book, the pathophysiological risk factors of progression from normoglycemia to prediabetes and the lifestyle modifications and pharmacological interventions for preventing or delaying the development of glucose intolerance is examined. Furthermore, the insulin signaling pathway regulates the cellular uptake of glucose and wholebody metabolic homeostasis in mammalians. This book explores the improvement of estrogen signaling in preventing the comorbidities of insulin resistance. The next chapter focuses on nutritional management during the perioperative period, focusing on glucose metabolism and insulin sensitivity. There are three major problems for nutritional management during the perioperative period. These problems are addressed and suggestions are made on how to alleviate them. Finally, Cystic Fibrosis (CF) is the most common lethal inherited disorder in Caucasians, affecting 1 in 2,500 - 2,800 live births. The last chapter examines impaired glucose tolerance in cystic fibrosis.

Read more less

Book Synopsis

Read more less

Book SynopsisThyroid nodules are commonly diagnosed in adults, although they are rare in children affecting only 1% - 2% of this population. Since the late 1960''s, ultrasound (US) has become essential in the examination of the thyroid gland as a non-invasive, rapid and easily reproducible imaging study. This book provides the reader with a framework from which to develop a differential diagnosis, risk factors and evaluation plan for both children and adults presented with thyroid nodules. Risk factors and management of a thyroidectomy are presented as well, and the challenges it poses for the surgeon who undertakes endocrine surgery. The final chapter evaluates the association between Hashimoto''s thyroiditis and differentiated thyroid cancer.

Read more less

Book SynopsisThis monograph presents an overview of the lysosome and its different roles in the maintenance of cellular homeostasis. It also provides a description of the various pathophysiologic changes associated with the lysosomal storage disorders. Therapeutic considerations and aspects relating to genetic counselling are covered in the final section. Several diagrams are provided to facilitate greater understanding of relevant themes. Additionally, contextual material is given at the end of each chapter, which elaborates on some of the entries brought up in the discussions. The book is written by an expert in the field who has been engaged in basic and clinical research. It offers a broad perspective and should appeal to both novices and experts in the field who seek a single resource that provides a comprehensive examination of the relevant topics. Issues covered should appeal to both the basic scientist and the clinician.

Read more less

Book SynopsisPituitary adenomas are benign neoplasms that are associated with a variety of endocrinological disorders, which in turn cause substantial difficulties not only in the physical health of the affected individuals, but also in their psychosocial state. Consequently, the imperative need for a prompt and accurate diagnosis of this tumor mobilises investigators to concentrate and carry out their basic research in this particular area. Moreover, the wish to develop and try new therapeutic methods in daily practice brings together physicians from different medical disciplines; all of them cooperate harmonically to achieve the best for their patients. It is the intention of Pituitary Adenoma: Pathophysiology, Diagnosis and Treatment Options to illustrate the current scientific results regarding the pathogenesis and progression of this neoplasm and also to explain in every detail the diverse diagnostic and therapeutic modalities used nowadays. In order to accomplish this aim, leading specialists were invited to participate with certain topics in the book, according to their field of expertise. In brief, this completed work fulfills the initial expectations of the editor, the authors and the publisher, which are indeed glad to present this book to its wide intended audience. All of them are convinced that the content of its chapters will be a useful guide not only for medical professionals and students, but also for other neuroscientists exploring the secrets of pituitary adenomas pathogenesis.

Read more less

Book SynopsisWide variety of pesticides and other synthetic chemicals may disrupt the normal function of the endocrine system, cause alteration and also attack the immune system of humans and wildlife at very low concentration levels. Chapter One of this book provides an overview of analytical methods, including sample preparation steps, chromatographic separation and detection of endocrine disrupting pesticides in a variety of food, environmental and biological matrices. Chapter Two studies endocrine disrupting compound (EDC) exposure from recycled wastewater compared to other water related risks in developed and developing nations. Chapter Three summarizes the role of EDCs on pregnancy and birth outcomes, included but not limited to fertility problems, premature birth, low birth weight, and miscarriage along with in-vitro, animal, and epidemiological studies. In the last chapter, the worst EDCs will be revealed and their related potential hazardous health risks to humans are discussed. Furthermore, suggestions to help the reader avoid such toxic chemicals are presented.

Read more less

Book SynopsisA Clinical Guide to Thyroidectomies is a comprehensive compilation that gives extensive detail on thyroid surgery, with examples illustrated by photographs and artwork. It aims to help surgeons practice safe and adequate thyroid surgery and provides updates on new technologies and techniques, such as robotic and remote site thyroidectomy. Thyroid surgery is practiced not only by dedicated endocrine surgeons, but also by general surgeons, surgical oncologists, and head and neck otolaryngologists. This book will be useful for practitioners in all of these disciplines.

Read more less

Book SynopsisSurgery remains a challenge for young learners. Perhaps the most difficult of all surgeries are those done on the liver, biliary tree and pancreas. These organs are difficult to expose, difficult to operate and the patients are often difficult to recover. There are significant consequences for any missteps on what is a narrow pathway to a successful outcome. The skills needed to master surgery on these organs are hard to acquire. The volume of information presented to students is enormous and complex to parse. HPB textbooks contain a large amount of information from various authors but are often poorly coordinated. Surgical manuals contain significant anatomic details and descriptions but have difficulty transferring key concepts. Experienced surgeons are often oblivious to their skills and communicate poorly to their students regarding the things they do or understand that make them wise. This book tries to capture this wisdom. The topics in this book are most applicable to hepatobiliary and pancreatic surgeons but really extend to all general surgeons. Anyone who operates in the abdomen must have a basic understanding of these dominant organs; general surgery trainees and staff are an additional focus of this book. The skills needed for a modern surgeon to succeed are much broader than the scalpel tip. Section I, HPB Surgical Craft, imparts important lessons on the laws of human interactions and cognitive aspects of surgery. Sections on the anatomy and operations on the liver, pancreas and bile ducts are presented. The expanded gallbladder section and pancreatitis chapters are of particular importance to general surgery residents. This book has been written in a readable and entertaining style, with many fun historical and contemporary quotes dotted throughout. The Wise Scalpel is an attempt to impart knowledge and understanding to students and practicing surgeons at all levels. The book focuses on tips, traps and underlying truths about the diseases of these organs and their surgical treatment. While this book will not supplant the struggle needed to move from novice to expert surgeon, hopefully it will quicken the process and help avoid some of the dangers and frustrations along the way.

Read more less

Book SynopsisA comprehensive selection of teaching tools for general anatomy and pathology. Each flip chart in the series offers a complete overview and understanding of the subject matter. Ideal for student or patient education. Suitable for the home, the school library, or physicians office. Can be written on by dry marker.

Read more less

Book SynopsisThe aim of this book is twofold: to promote an awareness of cultural differences in connection with sexual medicine among health care providers, and to demonstrate how such differences are relevant to the care and treatment of patients with sexual issues. Individual sexuality represents the cumulative effects of biological, psychological, and cultural influences. Yet much of the study of sexuality—including issues ranging from sexual identity to sexual response—has been conducted through a Western lens. Although a substantial body of work in anthropology has taken up the study of human sexuality from a cross-cultural perspective, two points are notable. First, this work seldom crosses the desks of medical and psychological health practitioners, and second, the relevance of specific cultural differences is rarely apparent to the typical sexual health practitioner. To address this situation, this book adopts a global perspective, focusing on how cultural practices and values can impact health care, treatment, and outcomes. In this regard, it covers three broad domains: Sexual Identity and Orientation; Sexual Response and Dysfunction; and Sexual Diversity. Each chapter consists of two parts: a general description of the relevant issues, and a discussion of how these issues can be relevant to clinical practice. The book offers a valuable, practical tool for specialists in sexual medicine and sexual psychology, for sexual healthcare givers, and for sexological researchers who want to better serve their patients by developing an awareness of and sensitivity to cultural differences, and by providing a framework for dealing with issues of sexuality and sexual health that takes cultural values into consideration, while adhering to best practices in patient care.Trade Review“The book has something to teach everyone, from the novice just beginning to understand the cross disciplinary nature of sexual health care to the seasoned sexual health professional looking to enhance their understanding of specific cultures or sub-cultures. As an educational resource tool, the book is worth being read and kept as a resource … . having read it, I look forward to treating my patients more effectively and to the many lively discussions that will be engendered by this work.” (Elisabeth Gordon, Journal of Sex & Marital Therapy, May 6, 2021)Table of ContentsPart I: Introduction.- Culture and Practice: Identifying the Issues.- Role of Medical Anthropology in Understanding Cultural Differences in Sexuality.- Part 2: Sexual Issues, Identity, and Challenges.- Socio-cultural perspectives, challenges, and approaches to sexual health in the Indian subcontinent.- Lesbian, Gay, and Bisexuality from a Cross-Cultural Perspective.- Transcultural Homo- and Trans-Phobia.- Impact of Chinese Traditional Culture on Sexuality.- Sexual Fluidity Behind Culture.- Part 3: Dealing with Sexual Issues.- Middle East Cultural Challenges and the Treatment of Sexual Problems in Men.- Central Asian Challenges in Sexual Issues.- Western, Asian, and Middle Eastern societies’ cultural attitudes and barriers impacting the management of sexual health care.- Latin American and Latina/Latino Issues in Sexual Health.- Cultural Issues Impacting the Acceptance of Psychosexual Therapy.- Normal or normative? Italian medical experts' discourses on sexual ageing in the Viagra era.- Part 4: Sexual Differences and Cultural Variation.- Pleasure, Orgasm, and Sexual Mutilations in Different Cultural Settings.- Disposition and Treatment of Paraphilia in Non-Western Cultures.- Disability and Sexuality.- Sexual Surgery through the Ages, in Varying Cultures.- Pornography Use: What Do Cross-Cultural Patterns Tell Us?.- Cross Cultural Research: Opportunities and Strategies for Discovery.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book SynopsisThe sixth edition of this highly popular text retains its comprehensive coverage of endocrine basics from previous editions while featuring entirely new chapters on several topics, including the assessment of endocrine function, sexual differentiation, growth regulation, the thyroid, the adrenals, and calcium homeostasis. Chapters have been updated and reorganized to make information easily accessible in concise form, and new figures and tables have been added to enhance the presentation of complex concepts. Fundamental principles of endocrine physiology are reinforced with illustrative examples from clinical observation and the limitations of current knowledge are properly identified. The ideal resource for students entering the field, the Textbook of Endocrine Physiology aims to provide for all a solid basis in fundamentals of endocrinology and for some, inspiration for the pursuit of advanced medical or graduate studies in the field.Trade ReviewReview(s) from previous edition(s)provides a succinct account of basic endocrine function * Baslib Book List *The second and third chapters "Genes and Hormones" and "Mechanisms of Hormone Action" are clear and useful guides to understanding the molecular and biochemical bases of hormonal action ... valuable for the medical student. * General and Comparative Endocrinology 91 *the expertise of the contributors in their fields is evident throughout; and the approach and level of detail are appropriate in the UK for second-year preclinical students, for those studying endocrine options and for those in clinical years needing to refresh and apply their knowledge of physiology. * BM. A. Radcliffe, Experimental Physiology *Excellent introductory text. * Joseph Jarabak, University of Chicago *It is a must read for graduate students and fellows. * Doris Baktuska, M.D., Medical College of Pennsylvania *Excellent text. I would recommend it as required reading for all medical students. * Romesh Khardori, M.D., Southern Illinois University School of Medicine *Well written by the best experts in the field. * Michael D. Lumpkin, PhD, Georgetown University Medical School *This text succeeds in providing excellent, very readable coverage of the field of endocrinology. The clearness of writing is commendable. This text can be highly recommended for graduate level courses and for medical students beyond the first year. * Endocrine News *In summary, this textbook incorporates modern concepts inan excellent, readable, concise, and comprehensive introduction or review of endocrine physiology. * Annals of the Royal College of Physicians and Surgeons of Canada *The coverage, readability, currency, and cost make Griffin and Ojeda's newest edition a best buy for classroom use or overall review purposes. * Item *It remains a solid text book of endocrinology written in a clear, no-nonsense style. * Physiology News, No 58 *Table of ContentsContributors ; 1. Organization of the Endocrine System ; 2. Genes and Hormones ; 3. Mechanisms of Hormone Action ; 4. Assessment of Endocrine Function ; 5. The Anterior Pituitary and Hypothalamus ; 6. The Posterior Pituitary and Water Metabolism ; 7. Sexual Differentiation ; 8. Female Reproductive Function ; 9. Male Reproductive Function ; 10. Fertilization, Implantation, and Endocrinology of Pregnancy ; 11. Growth Regulation ; 12. The Thyroid ; 13. The Adrenal Glands ; 14. Calcium Homeostasis ; 15. Glucose, Lipid, and Protein Metabolism ; Index

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

978-0306448096

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

Book Synopsis

Read more less

Book SynopsisAn eye-opening book that reveals crucial information every woman taking hormonal birth control should know This groundbreaking book sheds light on how hormonal birth control affects women--and the world around them--in ways we are just now beginning to understand. By allowing women to control their fertility, the birth control pill has revolutionized women's lives. Women are going to college, graduating, and entering the workforce in greater numbers than ever before, and there's good reason to believe that the birth control pill has a lot to do with this. But there's a lot more to the pill than meets the eye.Although women go on the pill for a small handful of targeted effects (pregnancy prevention and clearer skin, yay!), sex hormones can't work that way. Sex hormones impact the activities of billions of cells in the body at once, many of which are in the brain. There, they play a role in influencing attraction, sexual motivation, stress, hunger, eating patterns, emotion regulation, friendships, aggression, mood, learning, and more. This means that being on the birth control pill makes women a different version of themselves than when they are off of it. And this is a big deal. For instance, women on the pill have a dampened cortisol spike in response to stress. While this might sound great (no stress!), it can have negative implications for learning, memory, and mood. Additionally, because the pill influences who women are attracted to, being on the pill may inadvertently influence who women choose as partners, which can have important implications for their relationships once they go off it. Sometimes these changes are for the better . . . but other times, they're for the worse. By changing what women's brains do, the pill also has the ability to have cascading effects on everything and everyone that a woman encounters. This means that the reach of the pill extends far beyond women's own bodies, having a major impact on society and the world. This paradigm-shattering book provides an even-handed, science-based understanding of who women are, both on and off the pill. It will change the way that women think about their hormones and how they view themselves. It also serves as a rallying cry for women to demand more information from science about how their bodies and brains work and to advocate for better research. This book will help women make more informed decisions about their health, whether they're on the pill or off of it.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less

a huge range and FREE tracked UK delivery on ALL orders.

Read more less