Diseases and disorders Books
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Basic Skills PJ: Praktische Tipps für Chirurgie
Book SynopsisDieses Buch enthält wertvolle praktische Anleitungen und Tipps für die PJ-Tertiale Innere und Chirurgie und bereitet optimal auf das mündliche Staatsexamen vor. Von A wie Anamnese bis Z wie Zugänge legen werden alle Schritte und Handgriffe mit vielen Bildern und kurzen Texten erklärt. Auch schon für die Famulatur ist dieses Buch eine große Hilfe. So können Sie sich ideal auf die Zeit in Praxis und Klinik vorbereiten und wissen Bescheid, wenn Sie beim Patienten sind oder mit Kollegen zusammen arbeiten. Neben der Beschreibung der praktischen Handgriffe bietet das Buch außerdem:• Checklisten – Welches Material benötige ich wofür?• Merksätze – Was sind die Dos and Don´ts?• Zwischenmenschliches – Dinge, die sonst nicht im Lehrbuch stehen.Der HerausgeberDr. Carl Meißner ist Allgemeinchirurg in der Allgemein- und Viszeralchirurgie am Klinikum Magdeburg. Sein PJ ist noch nicht so lange her und er weiß noch sehr genau, welches Handwerkszeug ein junger PJler braucht.Table of ContentsAnamnese und klinische Untersuchung.- Hygiene.- Chirurgische Instrumentenlehre.- Die Visite.- Atemwege.- Zugänge und Katheter.- Diagnostische Punktion (Aszites, Pleura und Kniegelenk).- Im Operationssaal.- Wundbehandlung (Wundversorgung und Wundbeurteilung).- Notfall im klinischen Alltag.- Durchführung und Bewertung internistischer Diagnoseverfahren.- Diagnostik und Beurteilung im Notfall.- Wissenswertes zur Anamnese und Untersuchung.- Anhang.
£22.99
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Pocket Guide Anästhesie
Book SynopsisDieses handliche Kitteltaschenbuch vermittelt anhand von zahlreichen Übersichten, Tabellen und stichwortartigen Fakten absolutes Praxiswissen für den Berufsalltag von Anästhesisten. Gespickt mit vielen Hinweisen zum ganz konkreten Vorgehen sowie auf Fallstricke, Gefahrensituationen und Besonderheiten, bietet es vor allem dem Berufsanfänger in der Anästhesiologie das nötige Wissen, um sowohl bei Erwachsenen als auch bei Kindern eine sichere Anästhesie, Analgesie oder Sedierung durchzuführen. Table of Contents1. Allgemeinanästhesie.- 2.Regionalanästhesie.- 3.Analgosedierung.- 4. Kinderanästhesie.- 5. Arbeitstechniken.-6. Medikamente.- 7. Anästhesie bei Begleiterkrankungen.- 8. Anästhesie in der Allgemein-, Viszeral- und Transplantationschirurgie.- 9. Postanästhesiologisches Management.
£32.99
Springer Antibiotika am Krankenbett 2019 2020
Book SynopsisEinteilung der Antibiotika.- Generika - Handelsnamen.- Handelsnamen. - Generika.- Leitsätze der Antibiotika.- Häufigste Fehler bei der Antibiotikatherapie.- Wichtige Infektionen - wichtige mikrobiologische Diagnostik.- Zusammenarbeit mit Mikrobiologen.- Resistenz klinisch wichtiger Erreger.- Häufigste Erreger - Antibiotikaauswahl.- Antibiotika, Antimykotika: Spektrum Dosierung Nebenwirkungen Kosten.- Antibiotikatherapie der wichtigsten Infektionen bei Kindern und Erwachsenen.- Therapie der häufigsten bakteriellen Endokarditiden.- Mindestbehandlungsdauer von bakteriellen Infektionen.- Versagen der Antibiotikatherapie.- Differentialdiagnose, Fieber unklarer Genese.- Dosierung von Antibiotika bei eingeschränkter Nierenfunktion.- Antibiotikatherapie bei Hämodialyse, Peritonealdialyse und kontinuierlicher Hämofiltration.- Antibiotikatherapie in der Schwangerschaft und Stillzeit.- Antibiotika bei Lebererkrankungen.- Diffusion von Antibioti
£26.59
New India Publishing Agency Wildlife Medicine and Health Management
Book Synopsis
£209.90
Springer Rheumatic Fever
Book SynopsisToday rheumatic fever is still the most common cause of heart disease in children and young adults in developing countries. This disease is typically associated with poverty, in particular with poor housing, overcrowding and inadequate medical care. Rheumatic fever has almost disappeared from economically developed countries; this trend has paralleled improvements in standards of living. However, the recent resurgence of rheumatic fever in middle-class families in the U. S. A. has re-emphasized the importance of this disease in the developed countries as well. Prevention and control of rheumatic fever and rheumatic heart disease is an important part of the WHO cardiovascular disease program. Based on earlier WHO experience, and on the magnitude of the problem, it was realized that concerted action was needed to combat this significant cause of cardiovascular morbidity and mortality. The present program has been developed on the principle that sound knowledge and reliable technology already exist for implementing community programs for the prevention and control of rheumatic fever and rheumatic heart disease with the intention of extending activities toward nationwide coverage. The first edition of this book was an excellent instrument to assist in the control of this disease. The present volume with dissemination of knowledge to health personnel will contribute to closing the gap between knowledge and implementation and it links with WHO's endeavors in prevention and control of rheumatic fever and rheumatic heart disease.Table of Contents1 Definitions, history, and geography.- Definitions of rheumatic fever and related terms.- Brief history of rheumatic fever.- Incidence and prevalence.- Community medicine and public health importance.- 2 Etiology and epidemiology.- Streptococcal infections.- Host factors.- Environment.- 3 Pathogenesis and pathology.- Pathogenesis.- Pathology.- 4 Clinical manifestations.- Mode of onset.- Carditis.- Joint involvement.- Jaccoud’s arthritis.- Chorea.- Subcutaneous nodules.- Erythema marginatum.- Other manifestations.- Duration of the rheumatic attack.- Rheumatic fever in the adult.- 5 Laboratory manifestations.- Evidence of a recent streptococcal infection.- Evidence of systemic inflammation.- Laboratory evidence of heart involvement.- 6 Diagnosis.- Jones criteria.- Critique of the criteria.- 7 Differential diagnosis.- Musculoskeletal conditions simulating rheumatic fever.- Conditions simulating chorea.- Other common diagnostic errors.- Cardiac conditions simulating rheumatic carditis and rheumatic heart disease.- 8 Treatment.- General measures and bed rest.- Antimicrobial treatment.- Analgesic and anti-inflammatory treatment.- Diuretics and cardiotonic medication.- Treatment of chorea.- 9 Sequels of rheumatic fever: chronic rheumatic heart disease.- Prognosis.- Mitral regurgitation.- Aortic regurgitation.- Mitral stenosis.- 10 Rheumatic recurrences.- Quantitative aspects.- Qualitative aspects.- 11 Prevention of recurrent attacks.- Continual parenteral prophylaxis.- Continual oral prophylaxis.- Duration of continual prophylaxis.- Obstacles to continual prophylaxis.- Mass prophylaxis.- 12 Prevention of first attacks of rheumatic fever.- Diagnosis of streptococcal pharyngitis.- Technique of taking a throat culture.- Diagnosis without a throat culture.- Treatment of streptococcal pharyngitis.- 13 Role of health care workers other than physicians in the control of rheumatic fever.- Health education.- 14 The future of rheumatic fever.- Streptococcal vaccine.- Other possible advances.- A future without vaccine.
£42.74
Sunway University Press Diabetes: Disarming the Silent Killer
Book SynopsisGathers a prominent group of global researchers who share expert knowledge and views on diabetes. Readers will gain insights into groundbreaking therapies and approaches to preventing and managing diabetes complications. The book, a result of the 3rd Cambridge-Oxford-Sunway Biomedical Symposium, further shares the most recent advances in diabetes research from a Malaysian perspective.Much research has contributed to a good understanding of diabetes, but a lot remains unknown. In this book, readers will learn about the current knowledge base and new areas of interest in the management of diabetes.This book contains two main sections. In the first, Expert Discourse, leading international professionals in the field share their views on and insights into diabetes and how its prevalence and complications can be reduced. Some contributors include Professor Sir Stephen O'Rahilly and Professor Fiona Gribble from University of Cambridge, and Professor John Todd from University of Oxford. The second section, Extended Abstracts, shares some of the work done by researchers in the field of diabetes.This book is suitable for educators, researchers, medical consultants, public health professionals, and the interested general public.Table of Contents Foreword Preface Introduction About the Editors Expert Discourse Human Obesity and Insulin Resistance: Lessons from Human Genetics - Stephen O'Rahilly What We Can Do to Prevent Diabetes and Its Complications - Khalid Abdul Kadir Prevention of Type 1 Diabetes - John Todd Epidemic and Epigenetic Drivers of Diabetes, Obesity and the "Circadian Syndrome" - Paul Zimmet Control of Metabolism by the Gut-Brain-Pancreatic Axis - Fiona Gribble Exogenous Ketones for Type 2 Diabetes - Kieran Clarke New Approaches to Diabetic Complications - Mark Cooper Type 2 Diabetes: The Search for Sustainable Solutions - Nick Wareham Extended Abstracts Cost-Effective Analysis for the Early Initiation of Insulin in Type 2 Diabetes Mellitus Patients in Malaysia Using a Discrete Event Simulation Model – M.H Wilson, K.C. Lee, B.C. Wu & H. Luh Prevalence, Diagnostic Criteria, Complications and Potential Biomarkers of Gestational Diabetes Mellitus in the Philippines – M. Pineda-Cortel, L. Santiago, T. Mamerto, A. Anastacio & R. Tiongco Interleukin-2 and Interleukin-6 Play Major Roles in the Global Rheumatoid Arthritis/Type 2 Diabetes Comorbidity Network – T.O. Liew, M. Rohit & L. Chandrajit Awareness, Knowledge and Prevention of Heart Attacks Among University Staff – E.C. Martin, L. F. Ng, S. Jemeela & A.J. Mohammed Angiotensin II Type 1 Receptor Methylation is Inversely Associated with HbA1c in Non-Diabetic Young Adults – W.F. Wan Omar, N. Ab Talib, A.N. Mohd Shah, A.S. Mohd Shah & A. Abdullah Fabrication of Oral Nano-Insulin Formulation for Regulating Blood Glucose Level – R. Zaman, I. Othman, A.Z. Zain & E.H. Chowdhury Early Screening of Diabetic Foot Ulcer Using PeDiCare – V. Vikneswaran, Y.F. Chong & M.H. Khaled Prevalence of Diabetes Mellitus Among Urban Population Based on Income – K.L. Liyanage, N.G. Neelawala & W.W. Kumbukgolla Awareness and Risk Perception of University Students Towards Diabetes Mellitus – A.M. Manoj & W.N. Ng Acknowledgements
£999.99
Springer Verlag, Singapore Sphingolipid Metabolism and Metabolic Disease
Book SynopsisThis book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.Table of ContentsChapter 1: Sphingolipids and Cholesterol.- Chapter 2: Sphingolipids in adipose: kin or foe?.- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis.- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins.- Chapter 6: Sphingosine 1-phosphate metabolism and signaling.- Chapter 7: Sphingomyelin synthase family and phospholipase Cs.- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions.- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment.- Chapter 10: Sphingolipids and asthma.- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer.- Chapter 12: Drug development in the field of sphinogolipid metabolism.- Chapter 13: Rare diseases in glycosphingolipid metabolism.
£125.99
Springer Verlag, Singapore Drug Repurposing for Emerging Infectious Diseases
Book SynopsisThis book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.Table of ContentsChapter 1_Repurposing of drugs: Introduction to technologies and application. - Chapter 2_The value added medicine: Pharmacovigilance re-evaluated. - Chapter 3_Polypharmacology and drug repurposing. -Chapter 4_Comparative transcriptome analysis for infectious diseases towards the identification of cellular pathways for drug repositioning. -Chapter 5_Repurposing of drugs for the treatment of microbial diseases. -Chapter 6_RNA-dependent RNA polymerase (RdRp) - a potential therapeutic approach for Coronavirus drug repositioning. -Chapter 7_Drug repurposing for emerging and re-emerging infectious diseases. -Chapter 8_Drug repurposing for the control of COVID-19.-Chapter 9_Repurposing of anti-inflammatory agents in the potential treatment of SARS 2CoV -2 infection. -Chapter 10_Repurposing of immune-modulators for the treatment of cancer with a QSAR approach. -Chapter 11_ Repurposing Cancer drugs towards antiviral targets in developing countries. -Chapter 12_Repurposed drugs for hematological malignancies. -Chapter 13_Reverse translational approach in repurposing of drugs for anticancer therapy. -Chapter 14_Repurposing of Minocycline: a tetracycline antibiotic for neurodegenerative disorders. -Chapter 15_Drug repurposing for Neglected diseases: Approaches, challenges and promising candidates.
£161.99
Springer Artificial Intelligence in Human Health and
Book Synopsis1. The Magic of Artificial Intelligence-1.- 2. Magic of Artificial Intelligence-2.- 3. Deep Reinforcement Learning in Medical Science: Methods, Applications, and Future Directions.- 4. The problem of Generialization and Explainability in deep learning algorithms.- 5. Artificial Intelligence and Omics in Health and Diseases.- 6. Artificial Intelligence in Biomarker Discovery and Disease Diagnosis.- 7. Artificial Intelligence in Biomarker Discovery and Disease Diagnosis-2.- 8. Radiogenomics and Artificial Intelligence in Health and Diseases.- 9. Artificial Intelligence and the Use of Imaging Modalities in Biomedical Sciences.- 10. Artificial Intelligence in Cardiovascular Diseases.- 11. Artificial Intelligence in Obesity and Diabetes.- 12. AI-Powered Revolution in Infectious Disease Management: From Early Diagnostics to Drug Discovery.- 13. Artificial Intelligence in Oncology.- 14. Artificial Intelligence in Precision Oncology, Genomic Medicine and Disease Monitoring.- 15. Artificial Intelligence in Drug Discovery and Drug Target Interactions.- 16. Artificial Intelligence and Cancer Immunotherapy.- 17. Deep Learning Based Techniques for Detection of Cancer.
£170.99
HardPress Publishing The Elements of Medicine or a Translation of the Elementa Medicinae Brunonis
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£24.75
£10.72
Bookvault Publishing NATURAL REMEDIES SUSTAIN ME Over 100 Herbal Remedies For Different Kinds of Ailments What The BIG Pharma Doesnt Want You To Know
£29.99
Taylor & Francis Perceived Health and Adaptation in Chronic Disease
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£39.99
Taylor & Francis Ltd Analysis of Complex Diseases
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£56.04
Taylor & Francis Ltd Colitis
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£39.99
Taylor & Francis Ltd Dangerous Sexualities
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£171.00
Taylor & Francis Ltd Dangerous Sexualities
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£44.64
Taylor & Francis The Disease of Virgins Green Sickness Chlorosis and the Problems of Puberty
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£128.25
Taylor & Francis Exercise and Chronic Disease
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£65.54
Taylor & Francis The Disease of Virgins Green Sickness Chlorosis and the Problems of Puberty
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£43.99
Taylor & Francis Ltd Chronic Illness Vulnerability and Social Work
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£137.75
Taylor & Francis Epidemic Malaria and Hunger in Colonial Punjab
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£128.25
Taylor & Francis Ltd When the Bubble Bursts
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£49.39
Cambridge University Press The Concepts of Illness Disease and Morbus
Book SynopsisDr Taylor's book analyses the disease concept as it developed in medical history and seeks to clarify it with the help of concepts largely derived from logical class theories. A solution is proposed to the problem of how to distinguish between the class of 'patients' and the class of 'healthy persons' which corresponds to the actual diagnostic practices of doctors. The earliest theories of disease postulated concrete entities which exist independently of the body. The notion of disease entity has lost its original ontological connotations and instead its important feature has become the possession of a unitary and self-contained character. Dr Taylor describes the modern theories as essentially 'reactive' in character, that is the symptoms of a disease are the bodily reactions to the 'noxae'. After seeing the subject in its historical content, Dr Taylor goes on to discuss in detail the notion of the classification of diseases, making extensive use of modern views on the logic of classesTable of ContentsAcknowledgements; 1. Early notions of disease; 2. Ontological theories of disease; 3. Reactive theories of disease; 4. Source indicators and their perception; 5. Classes and classifications; 6. Morbidity; 7. Morbi; 8. Molecular morbi; 9. Summary; References; Name index; Subject index.
£29.44
Cambridge University Press Nitric Oxide in Bone and Joint Disease
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£34.19
Cambridge University Press Histiocytic Disorders of Children and Adults
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£75.99
Cambridge University Press Hyperthermic and Hypermetabolic Disorders
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£47.49
Cambridge University Press WHO Manual for the Standardized Investigation and Diagnosis of the Infertile Couple
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£24.99
Cambridge University Press Hyperthermic and Hypermetabolic Disorders
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£121.50
Cambridge University Press The Cambridge Historical Dictionary of Disease
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£29.99
Cambridge University Press Making Sense of Illness
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£73.14
Cambridge University Press Making Sense of Illness
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£33.24
Cambridge University Press Functional Somatic Syndromes Etiology Diagnosis and Treatment
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£145.00
Cambridge University Press The Skin Microflora and Microbial Skin Disease
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£75.99
Cambridge University Press Functional Somatic Syndromes
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£82.64
Cambridge University Press The Cambridge Historical Dictionary of Disease
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£70.29
Cambridge University Press Orthorexia Nervosa
Book Synopsis
£28.49
Cambridge University Press The Movement Disorders Prescribers Guide to
Book SynopsisThis concise, yet authoritative, clinical reference guide fulfils the needs of diverse clinicians, pharmacists and allied health professionals prescribing for Parkinson''s disease and movement disorders in contemporary clinical practice. With chapters on newly approved drugs and their effects on motor and non-motor symptoms, information is also given on their use in particular populations including the elderly and patients with cognitive impairment. Each chapter includes pharmacological/biochemical rationale for drug use, a general guide to therapeutic use, pharmacokinetics, interaction profile, adverse effects, dosing and use, special population considerations, costs and value for money considerations, clinical vignette, a summary overview, and suggested reading. Ordered alphabetically and perfect for quick reference use, the guide is practical and essential for all prescribers with responsibility for patients with Parkinson''s disease, including neurologists, geriatricians, internists, neurosurgeons, psychiatrists, family physicians, pharmacists as well as allied health professionals and resident, fellow, and student trainees in all related medical fields.
£47.49
HarperCollins Publishers Inc Survival of the Sickest
Book Synopsis
£999.99
HarperCollins Publishers Inc Genomic Messages
Book SynopsisTwo leaders in the field of genetics—a bioethicist-health lawyer and an obstetrician-gynecologist geneticist—answer the most pressing questions about the application of new genetics to our universal medicine and what personalized medicine means for individual healthcare.Breakthroughs in genetic research are changing modern medicine and pharmaceuticals. But what are these changes and how do they affect our individual care? Genomic Messages examines these groundbreaking changes and the questions they raise: What kind of specific medical innovation do we have to look forward to now and tomorrow? How will this “flood” of genetic messages change our lives, our interaction with our physicians and our healthcare system?Groundbreaking and provocative, Genomic Messages fuses the often conflicting worlds of medicine and law to provide information and insight that will impact the health choices of every one of us, from how medicine is pra
£999.99
HarperCollins Publishers Inc The Cancer Code A Revolutionary New Understanding
Book Synopsis
£999.99
Pearson Education (US) Genetic Analysis
Book SynopsisAbout our authors Mark F. Sanders has been a faculty member in the Department of Molecular and Cellular Biology at the University of California, Davis, since 1985. In that time, he has taught more than 150 genetics courses to nearly 35,000 undergraduate students. Although he specializes in teaching the genetics course for which this book is written, his genetics teaching experience also includes a genetics laboratory course, an advanced human genetics course for biology majors, and a human heredity course for nonscience majors, as well as introductory biology and courses in population genetics and evolution. He has also served as an advisor to undergraduate students and in undergraduate education administration, and he has directed several undergraduate education programs. Dr. Sanders received his B.A. degree in Anthropology from San Francisco State University, his M.A. and Ph.D. degrees in Biological Anthropology from the University of California, LTable of Contents1. The Molecular Basis of Heredity, Variation, and Evolution 2. Transmission Genetics 3. Cell Division and Chromosome Heredity 4. Inheritance Patterns of Single Genes and Gene Interaction 5. Genetic Linkage and Mapping in Eukaryotes 6. Genetic Analysis and Mapping in Bacteria and Bacteriophage Application Chapter: Part I: Genetic Counseling 7. DNA Structure and Replication 8. Molecular Biology of Transcription and RNA Processing 9. The Molecular Biology of Translation Application Chapter: Part II: Genetic Testing 10. Chromosome Chapter Title TBD 11. Gene Mutation, DNA Repair, and Homologous Recombination 12. Chromosome Chapter Title TBD 13. Regulation of Gene Expression in Bacteria and Bacteriophage 14. Regulation of Gene Expression in Eukaryotes 15. Analysis of Gene Function by Forward Genetics and Reverse Genetics Application Chapter: Part III: Cancer Genetics 16. Recombinant DNA Technology and Its Applications 17. Genomics: Genetics from a Whole-Genome Perspective 18. Organelle Inheritance and the Evolution of Organelle Genomes 19. Developmental Genetics 20. Genetic Analysis of Quantitative Traits Application Chapter: IV: Personalized Medicine 21. Population Genetics and Evolution at the Population, Species, and Molecular Levels Application Chapter: V: Forensic Genetics
£243.66
Random House USA Inc Saving Milly
Book SynopsisMorton Kondracke never intended to wed Millicent Martinez, but the fiery daughter of a radical labor organizer eventually captured his heart. They married, raised two daughters, and loved and fought passionately for twenty years. Then, in 1987, Milly noticed a glitch in her handwriting, a small tremor that would lead to the shattering diagnosis of Parkinson’s disease. Saving Milly is Kondracke’s powerfully moving chronicle of his vital and volatile marriage, one that has endured and deepened in the face of tragedy; it also follows his own transformation from careerist to caregiver and activist, a man who will “fight all the way, without pause or rest, to ‘save’ his beloved Milly.” *(* Linda Bowles, The Washington Times)
£12.60
Thomas Nelson Publishers The Great Physicians Rx for Heartburn and Acid
Book SynopsisJordan Rubin, along with Joseph Brasco, MD, is not so sure that taking antacids and powerful proton pump inhibitors best for people's healing or their health. The Great Physician's Rx for Heartburn and Acid Reflux reveals a more natural approach to beating heartburn and acid reflux based on the Seven Keys to Health and Wellness.
£9.70
Johns Hopkins University Press Adrenaline and the Inner World
Book SynopsisIt includes an extensive glossary.Trade ReviewThe only book you'll need to thoroughly understand the topic and its related health issues. California Bookwatch 2006 An interesting, well-written book geared to academics and professionals but also intended for patients and people supporting them. Choice 2006Table of ContentsPreface1. The Inner WorldThe Seed and the SoilCannon's CanonsThe Comfort Level in Building 10An Amazing Cooking ExperimentDeath by FootballThe Sleeper HoldSnakes That Faint?Rules of the GameSame DifferenceThe All-Day Sucker2. The "Automatic Nervous System"TransformersVeggingGood HousekeepingThe Hot LineHow Does the Autonomic Nervous System Work?3. The Arbiters of the Inner WorldThe Fat above the KidneysOn the Risk of Being a Physician's SonWhat's in a Name?Catecholamines Look Like CatsAdrenaline's Effects on the BodyNeuronal Soda PopThe Getaway Car AnalogyThe Atavistic Catecholamine"First I Secreted a Hell of a Lot of Adrenaline"A Play-Doh Model of the BrainThe Nobel Chemicals4. The Rest of the CastThe Axis PowersThe Water Works and Kosher Pickle TreatmentSalt SenseYour Own Brand of MorphineCytokinesSexLeptin5. Stress as a Scientific IdeaA Brief History of StressStress Response Patterns6. DistressCharacteristics of DistressBiblical Lie DetectionDistress versus the General Adaptation SyndromeFight Isn't FlightThe Nose of GodStressToonsStress in Evolutionary PerspectiveWhy Evolution Is a Worthwhile Theory and Creationism Isn'Darwin and EthologyThe Price of Complexity Is Eternal StressPrimitive Specificity8. DysautonomiasThe "Mind-Body" ProblemPrimary versus Secondary DysautonomiasSecondary DysautonomiasPrimary Dysautonomias9. Tests for DysautonomiasPhysiological TestsNeuropharmacological TestsNeurochemical TestsNeuroimaging Tests10. Treatments for DysautonomiasNondrug TreatmentsDrug Treatments11. Drugs and the FamilyCatecholamines as DrugsLegal AddictionsCocaineSpeed KillsMorphineBarbs and BenzosYou Aren't What You Eat, Luckily12. The Future: Scientific Integrative MedicineReturn of the Getaway CarAllostatic Load for People Who Hate SnakesThe DialecticDarwinian MedicineTactics and Strategies of Scientific Integrative MedicineWhat, How, and WhyConclusionGlossaryReferencesIndex
£32.30
Johns Hopkins University Press Mechanism Experiment Disease
Book SynopsisBertoloni Meli's critical study of this key figure and the works of his contemporaries-including Borelli, Swammerdam, Redi, and Ruysch-opens a wonderful window onto the scientific and medical worlds of the seventeenth century.Trade ReviewThe strength of Meli's work lies in his attention to detail in highly complex Latin works, and in his sensitivity to unpublished work, correspondence, diaries, and above all, to the technologies of illustration. -- William Poole Times Higher Education Distinguished as this work was, in Mechanism, Experiment, Disease Domenico Bertoloni Meli maintains there is a great deal more to Marcello Malpighi. In this new book-part biography, part intellectual history of anatomy (the philosophy and mechanics of the body), and part history of medicine in the 17th century-Bertoloni Meli tells readers why. What he does wonderfully is to locate Malpighi as a practicing physician during Italy's scientific revolution. Bertoloni Meli conveys the excitement of the new science, voices the tumult that ensued as opposing schools of thought clashed, and reminds readers that priority disputes are nothing new. JAMA Bertoloni Meli makes great use of Malpighi's wonderful epistolary consultations to remind readers that boundaries between research and practice have been drawn too sharply by historians. His use of overlooked medical correspondence increases the presence of Malpighi, the medical practitioner, working from bench to bedside four centuries before translational research hit the headlines. -- Helen Bynum JAMA The most comprehensive account to date of the works of Marcello Malpighi. -- Stephanie Eichberg The British Journal for the History of Science Bertoloni Meli's book is a very valuable and welcome contribution to the ongoing reassessment of the Scientific Revolution as a manifold process that involved all areas of natural knowledge-from physics to medicine-and reconfigured each and their mutual relations. -- Maria Pia Donato Isis Among the many lessons to be taken from Domenico Bertoloni Meli's carefully researched, persuasive and, at times, beautifully rendered book is that the life sciences in the early modern period must be studied with an eye to the history of science, medicine and philosophy... There is too much to praise and to learn from Meli's book to do it justice in a short review such as this. For several years now his work has represented a vital and inspiring force in the history medicine, and Mechanism, Experiment, Disease: Marcello Malpighi and Seventeenth-Century Anatomy in particular will enliven the study of early modern medicine in ways we cannot pretend to anticipate. But one thing we are confident about is that Meli's latest book should shape the new work to be done on eighteenth-century notions of mechanism, the emergence of pathology, and the history of visualization and its practices. -- Cynthia Klestinec and Gideon Manning MetascienceTable of ContentsAcknowledgmentsIntroduction: Anatomy, Medicine, and the New Philosophy1. Anatomical Research in the Second Half of the Seventeenth Century2. Malpighi's Role on the Anatomical Stage3. Medical Locations: The Sites of Malpighi's Work4. Mechanism and Mechanics5. Experiment and Collaboration6. Disease and Anatomy7. Structure and OrganizationPart I: The Rise of Mechanistic and Microscopic Anatomy: Malpighi's Formation and Association with Borelli1. The New Anatomy, the Lungs, and Respiration1.1. Changing Anatomical Horizons1.2. Malpighi's Bologna Apprenticeship: Anatomical Venues and Vivisection1.3. Malpighi's Pisa Apprenticeship: Microscopy and the New Philosophy1.4. Malpighi's Epistolae on the Lungs1.5. The Purpose of Respiration: Thruston, Lower, and Hooke2. Epidemic Fevers and the Challenge to Galenism2.1. Galenic Traditions and New Medical Thinking2.2. Borelli and the Sicilian Epidemics of 1647–482.3. Borelli, Malpighi, and the Pisa Epidemics of 16612.4. The 1665 Controversy between the Neoterics and the Galenists2.5. Malpighi's Risposta to Galenistarum triumphus3. The Anatomy of the Brain and of the Sensory Organs3.1. Atomism and the Anatomy of the Senses3.2. Brain Research in the 1660s: Willis, Steno, and Malpighi3.3. Malpighi's Anatomical Findings on Taste and Touch3.4. Fracassati's Far-Reaching Investigations3.5. Bellini and Rossetti: Atomistic Anatomy of Taste and TouchPart II: Secretion and the Mechanical Organization of the Body: Glands as the Centerpiece of Malpighi's Investigations4. The Glandular Structure of the Viscera4.1. The Revival of Glands4.2. Changing Perceptions on Glands: Glisson, Wharton, and Steno4.3. Malpighi's Treatise on the Liver4.4. The Brain and the Cerebral Cortex4.5. The Kidneys: Bellini and Malpighi4.6. The Spleen and Its Problems5. Fat, Blood, and the Body's Organization5.1. The Necessity of Matter and the Animal's Benefit5.2. Descartes on Fat, Blood, and Nutrition5.3. Malpighi on Fat and Its Philosophical Implications5.4. Blood Transfusions5.5. Malpighi on Heart Polyps and the Nature of Blood6. The Structure of Glands and the Problem of Secretion6.1. Different Perspectives on Glands6.2. Intestinal Glands and Their Implications6.3. The Mode of Operation of Glands6.4. Glands in the Theatre: Bellini, Sbaraglia, and Malpighi6.5. Nuck's New Taxonomy of GlandsPart III: Between Anatomy and Natural History: Malpighi andthe Royal Society7. The Challenge of Insects7.1. Changing Perceptions on Insects7.2. Redi: Experiments and Generation7.3. Malpighi: Historia and Anatomy7.4. Swammerdam: Metamorphosis and Classification7.5. Swammerdam and Malpighi: Microstructure and Iconography8. Generation and the Formation of the Chick in the Egg8.1. Generation and Its Problems8.2. Harvey: Epigenesis and the Role of the Faculties8.3. The Organs of Generation and the Problem of Fecundation8.4. Swammerdam and the Amsterdam Circle on Preformation8.5. Malpighi and the Formation of the Chick in the Egg9. The Anatomy of Plants9.1. Plants between Anatomy and Natural History9.2. Malpighi's Anatomy of Plants: Structure, Iconography, and Experiment9.3. Trionfetti, Malpighi, Cestoni, and the Vegetation of Plants9.4. Grew and Camerarius: Iconography, "OEconomy," and SexualReproductionPart IV: Anatomy, Pathology, and Therapy: Malpighi's Posthumous Writings10. The Fortunes of Malpighi's Mechanistic Anatomy10.1. Mechanistic Anatomy and Malpighi's Vita10.2. Writing about the Self10.3. Levels of Mechanical Explanation in Borelli and Malpighi10.4. Paolo Mini and the Soul-Body Problem10.5. Ruysch's Challenge and Boerhaave11. From the New Anatomy to Pathology and Therapy11.1. A Bologna Controversy and Its Wider Implications11.2. Sbaraglia's Challenge to Malpighi's Research11.3. Malpighi: The Medical Signifi cance of the New Anatomy11.4. Sbaraglia's Empiricism and Methodological Concerns11.5. Young Morgagni's Covert Intervention12. Medical Consultations12.1. Between Theory and Practice, Carnival and Lent12.2. Publishing Malpighi's Consultations12.3. Structure and Contents of Malpighi's Consultations12.4. Curing with the Pen: Francesco Redi12.5. A Broader Look at Medical Consultations: Vallisneri and MorgagniEpilogueList of AbbreviationsNotesReferencesIndex
£71.10
Johns Hopkins University Press Mechanism Experiment Disease
Book SynopsisBertoloni Meli's critical study of this key figure and the works of his contemporaries-including Borelli, Swammerdam, Redi, and Ruysch-opens a wonderful window onto the scientific and medical worlds of the seventeenth century.Trade ReviewThe strength of Meli's work lies in his attention to detail in highly complex Latin works, and in his sensitivity to unpublished work, correspondence, diaries, and above all, to the technologies of illustration. -- William Poole Times Higher Education Distinguished as this work was, in Mechanism, Experiment, Disease Domenico Bertoloni Meli maintains there is a great deal more to Marcello Malpighi. In this new book-part biography, part intellectual history of anatomy (the philosophy and mechanics of the body), and part history of medicine in the 17th century-Bertoloni Meli tells readers why. What he does wonderfully is to locate Malpighi as a practicing physician during Italy's scientific revolution. Bertoloni Meli conveys the excitement of the new science, voices the tumult that ensued as opposing schools of thought clashed, and reminds readers that priority disputes are nothing new. JAMA Bertoloni Meli makes great use of Malpighi's wonderful epistolary consultations to remind readers that boundaries between research and practice have been drawn too sharply by historians. His use of overlooked medical correspondence increases the presence of Malpighi, the medical practitioner, working from bench to bedside four centuries before translational research hit the headlines. -- Helen Bynum JAMA The most comprehensive account to date of the works of Marcello Malpighi. -- Stephanie Eichberg The British Journal for the History of Science Bertoloni Meli's book is a very valuable and welcome contribution to the ongoing reassessment of the Scientific Revolution as a manifold process that involved all areas of natural knowledge-from physics to medicine-and reconfigured each and their mutual relations. -- Maria Pia Donato Isis Among the many lessons to be taken from Domenico Bertoloni Meli's carefully researched, persuasive and, at times, beautifully rendered book is that the life sciences in the early modern period must be studied with an eye to the history of science, medicine and philosophy... There is too much to praise and to learn from Meli's book to do it justice in a short review such as this. For several years now his work has represented a vital and inspiring force in the history medicine, and Mechanism, Experiment, Disease: Marcello Malpighi and Seventeenth-Century Anatomy in particular will enliven the study of early modern medicine in ways we cannot pretend to anticipate. But one thing we are confident about is that Meli's latest book should shape the new work to be done on eighteenth-century notions of mechanism, the emergence of pathology, and the history of visualization and its practices. -- Cynthia Klestinec and Gideon Manning MetascienceTable of ContentsAcknowledgmentsIntroduction: Anatomy, Medicine, and the New Philosophy1. Anatomical Research in the Second Half of the Seventeenth Century2. Malpighi's Role on the Anatomical Stage3. Medical Locations: The Sites of Malpighi's Work4. Mechanism and Mechanics5. Experiment and Collaboration6. Disease and Anatomy7. Structure and OrganizationPart I: The Rise of Mechanistic and Microscopic Anatomy: Malpighi's Formation and Association with Borelli1. The New Anatomy, the Lungs, and Respiration1.1. Changing Anatomical Horizons1.2. Malpighi's Bologna Apprenticeship: Anatomical Venues and Vivisection1.3. Malpighi's Pisa Apprenticeship: Microscopy and the New Philosophy1.4. Malpighi's Epistolae on the Lungs1.5. The Purpose of Respiration: Thruston, Lower, and Hooke2. Epidemic Fevers and the Challenge to Galenism2.1. Galenic Traditions and New Medical Thinking2.2. Borelli and the Sicilian Epidemics of 1647–482.3. Borelli, Malpighi, and the Pisa Epidemics of 16612.4. The 1665 Controversy between the Neoterics and the Galenists2.5. Malpighi's Risposta to Galenistarum triumphus3. The Anatomy of the Brain and of the Sensory Organs3.1. Atomism and the Anatomy of the Senses3.2. Brain Research in the 1660s: Willis, Steno, and Malpighi3.3. Malpighi's Anatomical Findings on Taste and Touch3.4. Fracassati's Far-Reaching Investigations3.5. Bellini and Rossetti: Atomistic Anatomy of Taste and TouchPart II: Secretion and the Mechanical Organization of the Body: Glands as the Centerpiece of Malpighi's Investigations4. The Glandular Structure of the Viscera4.1. The Revival of Glands4.2. Changing Perceptions on Glands: Glisson, Wharton, and Steno4.3. Malpighi's Treatise on the Liver4.4. The Brain and the Cerebral Cortex4.5. The Kidneys: Bellini and Malpighi4.6. The Spleen and Its Problems5. Fat, Blood, and the Body's Organization5.1. The Necessity of Matter and the Animal's Benefit5.2. Descartes on Fat, Blood, and Nutrition5.3. Malpighi on Fat and Its Philosophical Implications5.4. Blood Transfusions5.5. Malpighi on Heart Polyps and the Nature of Blood6. The Structure of Glands and the Problem of Secretion6.1. Different Perspectives on Glands6.2. Intestinal Glands and Their Implications6.3. The Mode of Operation of Glands6.4. Glands in the Theatre: Bellini, Sbaraglia, and Malpighi6.5. Nuck's New Taxonomy of GlandsPart III: Between Anatomy and Natural History: Malpighi andthe Royal Society7. The Challenge of Insects7.1. Changing Perceptions on Insects7.2. Redi: Experiments and Generation7.3. Malpighi: Historia and Anatomy7.4. Swammerdam: Metamorphosis and Classification7.5. Swammerdam and Malpighi: Microstructure and Iconography8. Generation and the Formation of the Chick in the Egg8.1. Generation and Its Problems8.2. Harvey: Epigenesis and the Role of the Faculties8.3. The Organs of Generation and the Problem of Fecundation8.4. Swammerdam and the Amsterdam Circle on Preformation8.5. Malpighi and the Formation of the Chick in the Egg9. The Anatomy of Plants9.1. Plants between Anatomy and Natural History9.2. Malpighi's Anatomy of Plants: Structure, Iconography, and Experiment9.3. Trionfetti, Malpighi, Cestoni, and the Vegetation of Plants9.4. Grew and Camerarius: Iconography, "OEconomy," and SexualReproductionPart IV: Anatomy, Pathology, and Therapy: Malpighi's Posthumous Writings10. The Fortunes of Malpighi's Mechanistic Anatomy10.1. Mechanistic Anatomy and Malpighi's Vita10.2. Writing about the Self10.3. Levels of Mechanical Explanation in Borelli and Malpighi10.4. Paolo Mini and the Soul-Body Problem10.5. Ruysch's Challenge and Boerhaave11. From the New Anatomy to Pathology and Therapy11.1. A Bologna Controversy and Its Wider Implications11.2. Sbaraglia's Challenge to Malpighi's Research11.3. Malpighi: The Medical Signifi cance of the New Anatomy11.4. Sbaraglia's Empiricism and Methodological Concerns11.5. Young Morgagni's Covert Intervention12. Medical Consultations12.1. Between Theory and Practice, Carnival and Lent12.2. Publishing Malpighi's Consultations12.3. Structure and Contents of Malpighi's Consultations12.4. Curing with the Pen: Francesco Redi12.5. A Broader Look at Medical Consultations: Vallisneri and MorgagniEpilogueList of AbbreviationsNotesReferencesIndex
£41.50
John Wiley and Sons Ltd Functional Foods Nutraceuticals and Degenerative
Book SynopsisFunctional Foods, Nutraceuticals and Degenerative Disease Prevention is a compilation of different segments of functional foods and nutraceuticals focusing on their mechanism of action in the human body leading to disease prevention. Numerous chapters deal with different functional foods in terms of their efficacy, highlighting the mechanism of action of their ingredients. The book focuses on the biochemistry and molecular biology of the disease prevention process rather than simply compiling the benefits of functional foods and nutraceuticals. Aimed primarily at an audience comprised of researchers, industry professionals, food scientists, medical professionals and graduate level students, Functional Foods, Nutraceuticals and Degenerative Disease Prevention offers a mechanism-based interpretation for the effect of nutraceuticals within the human body. Ultimately, the discussion of the biological effects of a variety of functional foods will provide a wholesome approTable of ContentsContributors xv Preface xvii About the Editors xix 1 Functional Foods, Nutraceuticals, and Disease Prevention: A Window to the Future of Health Promotion 3 Gopinadhan Paliyath and Kalidas Shetty 1.1 Chronic Degenerative Diseases in Modern Society: Implications on Life Quality, Productivity, Economic Burden 3 1.1.1 Diet and lifestyle changes: the missing foods 3 1.1.2 Social and economic burden of chronic degenerative diseases 4 1.2 Health Regulatory Properties of Foods: “Prevention Is Better Than Cure” 5 1.2.1 Fruit and vegetable consumption and disease prevention 6 References 8 2 Functional Foods and Nutraceuticals 11 Chung-Ja C. Jackson and Gopinadhan Paliyath 2.1 Introduction 11 2.2 Definition of Functional Foods and Nutraceuticals 12 2.2.1 Effects of functional foods and nutraceuticals on major chronic diseases 16 2.3 Sources and Biological Effects of Functional Foods and Nutraceuticals in Nature 19 2.3.1 Flaxseed (Linum usitatissimum) 20 2.3.2 Phytoestrogens 21 2.3.3 Tomatoes 21 2.3.4 Garlic (Allium sativum) 21 2.3.5 Cruciferous vegetables 22 2.3.6 Citrus fruits 22 2.3.7 Cranberry 23 2.3.8 Tea 23 2.3.9 Wine and grapes 24 2.3.10 Chocolate 24 2.3.11 Fish 25 2.3.12 Dairy products 25 2.3.13 Carbohydrates 26 2.3.14 Meat 26 2.3.15 Vitamins 26 2.3.16 Minerals 27 2.4 Functional Foods and Nutraceuticals: Health Claims and Benefits 27 2.4.1 Oats 27 2.4.2 Psyllium 27 2.4.3 Soybeans 28 2.4.4 Phytosterols 29 2.4.5 Fiber 29 2.4.6 D-Tagatose 29 2.5 Qualifi ed Health Claims 29 2.5.1 Selenium and cancer 29 2.5.2 Antioxidant vitamins and cancer 30 2.5.3 Nuts (e.g., walnuts) and heart disease 30 2.5.4 Omega-3 fatty acids and CHD 30 2.5.5 Phosphatidylserine/Phosphatidylcholine and cognitive dysfunction and dementia 30 2.5.6 Folic acid and neural tube birth defects 30 2.6 Functional Foods and Nutraceuticals: Safety Issues 30 2.6.1 Echinacea 31 2.6.2 Ephedra (also called “ma huang, herbal ecstasy, or mahuanggen”) 31 2.6.3 Feverfew 31 2.6.4 Garlic 31 2.6.5 Ginger 32 2.6.6 Gingko biloba 32 2.6.7 Ginseng 32 2.6.8 Kava kava products 32 2.6.9 St. John’s Wort 32 2.7 Regulation of Functional Foods and Nutraceuticals 33 2.8 Public Education and Dietary Guidance 35 2.9 Concluding Remarks 36 References 37 3 Nutritional Genomics: Fundamental Role of Diet in Chronic Disease Prevention and Control 45 Amy J. Tucker, Branden Deschambault, and Marica Bakovic 3.1 Introduction 45 3.2 Nutrigenetics 46 3.2.1 Gene polymorphisms 46 3.2.2 Single nucleotide polymorphisms (SNPs) 47 3.2.3 Nonsynonymous single nucleotide polymorphisms (nsSNPs) 47 3.2.4 Regulatory single nucleotide polymorphisms (rSNPs) 48 3.2.5 Splice site single nucleotide polymorphisms (ssSNPs) 48 3.2.6 Trans-Acting rSNPs 48 3.3 Complexities of chronic disease research in nutrigenetics 49 3.4 Chronic Disease and Rare SNPs 50 3.4.1 Copy number variants 50 3.5 CVD and Nutrigenetics 51 3.6 Nutrigenetics and Cancer 51 3.7 Summary of Nutrigenetic Research Potential 51 3.8 Nutriepigenetics 52 3.8.1 Role of the epigenome 52 3.8.2 Cause of epimutations 52 3.9 Epimutations in Chronic Disease 53 3.9.1 Epimutations and macronutrients/micronutrients 53 3.9.2 Epimutations and phytochemicals 54 3.10 Summary of Epigenetic Research Potential 54 3.11 Nutrigenomics 54 3.11.1 Genomic impact of diet 55 3.11.2 Carbohydrates and gene interactions 55 3.12.3 Cholesterol and gene interactions 56 3.11.4 FAs, lipids, and gene interactions 58 3.11.5 Lipids and APOE 59 3.11.6 Diet and APOE 60 3.11.7 Lipids and hepatic lipase (HL) 60 3.11.8 Diet and LIPC 61 3.11.9 Interaction between APOE and HL 61 3.12 Vitamin A and Gene Interactions 61 3.12.1 Dual roles of vitamin A 62 3.13 Vitamin E and Nutrigenomics 62 3.13.1 Vitamin E and atherosclerosis 62 3.13.2 Vitamin E and cholesterol biosynthesis 63 3.14 Vitamin D and Gene Interactions 63 3.14.1 Vitamin D and breast cancer 63 3.14.2 Vitamin D and FAs 64 3.15 Phytoestrogens and Gene Interactions 64 3.15.1 Phytoestrogens and breast cancer 64 3.15.2 Phytoestrogens and lipid, glucose metabolism 64 3.16 Phytosterols and Gene Interactions 65 3.16.1 Phytosterols and cholesterol metabolism 65 3.16.2 Phytosterols and cancer 65 3.17 Polyphenols and Gene Interactions 65 3.17.1 Polyphenols and CVD 65 3.17.2 Polyphenols and cancer 66 3.18 Nutrigenomics Summary: Advantages, Limitations, Future 66 3.19 Conclusions 67 References 67 4 Nutraceuticals and Antioxidant Function 75 Denise Young, Rong Tsao, and Yoshinori Mine 4.1 Introduction 75 4.2 Oxidative Stress and ROS 75 4.2.1 Endogenous sources of ROS 76 4.2.2 Exogenous sources of ROS 77 4.3 Antioxidants and Antioxidative Defense Systems 77 4.3.1 Endogenous antioxidants and antioxidative defenses 77 4.3.2 Dietary antioxidants 79 4.4 Phytochemicals 79 4.4.1 Polyphenols 80 4.4.2 Amides 85 4.4.3 Carotenoids 86 4.4.4 Mechanism of antioxidant action 87 4.5 Antioxidant Amino Acids, Peptides, and Proteins 90 4.6 Mechanism of Action of Antioxidant and Antioxidative Stress Amino Acids, Peptides, and Proteins 91 4.6.1 Amino acids 91 4.6.2 Peptides and proteins 91 4.7 Production of Antioxidant Peptides 95 4.8 Recent Advances in Analytical Techniques for Measuring Antioxidant Capacity and Oxidative Damage 96 4.8.1 Chemical antioxidant capacity assay 96 4.8.2 Cell-based antioxidant assays 99 4.9 Health Benefi ts of Nutraceutical Antioxidants 101 4.9.1 Evidence of antioxidant efficacy in disease states 101 4.9.2 Failure of antioxidants to demonstrate efficacy 102 4.10 Conclusion 102 References 103 5 Composition and Chemistry of Functional Foods and Nutraceuticals: Infl uence on Bioaccessibility and Bioavailability 113 Jissy K. Jacob and Gopinadhan Paliyath 5.1 Introduction 113 5.2 Polyphenols as Antioxidants 115 5.2.1 Free radicals and endogenous antioxidant defense mechanisms 115 5.2.2 Diet and exogenous antioxidants (flavonoids) 115 5.2.3 Antioxidant properties of flavonoids 117 5.3 Antioxidant Activity of Anthocyanins 118 5.4 Anthocyanin Biosynthesis and Localization 119 5.5 Bioaccessibility and Bioavailability of Polyphenols 121 5.6 Microstructural Characteristics of Grape Juice 122 5.7 Physicochemical Properties of the Dialyzed Juice Fraction 123 5.8 Ultrastructural Analysis of Juice Fractions 124 5.9 Composition of Juice Fractions 126 5.10 Antioxidant Activity of Juice Fractions 129 5.11 Metabolism and Bioavailability of Flavonoids 132 5.12 Dietary Polyphenols and Prevention of Diseases 135 5.12.1 Polyphenols and cardiovascular diseases 135 5.12.2 Polyphenols and cancer 136 5.13 Increasing Health Benefi cial Properties of Juices 137 References 139 6 Cruciferous Vegetable-Derived Isothiocyanates and Cancer Prevention 147 Ravi P. Sahu and Sanjay K. Srivastava 6.1 Introduction 147 6.2 Metabolism of Xenobiotics 149 6.3 ITCs and Inhibition of Cancer 150 6.3.1 Pancreatic cancer 150 6.3.2 Brain cancer 152 6.3.3 Prostate cancer 152 6.3.4 Lung cancer 154 6.3.5 Breast cancer 155 6.3.6 Colon cancer 156 6.3.7 Hepatic cancer 156 6.3.8 Bladder cancer 157 6.3.9 Multiple myeloma (MM) 158 6.3.10 Head and neck squamous cancer 159 6.3.11 Ovarian cancer 159 6.3.12 Skin cancer 160 Acknowledgments 161 References 161 7 The Disease-Preventive Potential of Some Popular and Underutilized Seeds 171 Rajeev Bhat 7.1 Introduction 171 7.2 Oil Seeds and Their Therapeutic Potential 172 7.2.1 Nigella seeds (Nigella sativa L.) 172 7.2.2 Sunfl ower seed (Helianthus annuus L.) 172 7.2.3 Groundnut seed (Arachis hypogea L.) 183 7.2.4 Sesame seeds (Sesamum indicum L.) 184 7.2.5 Oilseed rape (Brassica napus L.) 184 7.2.6 Saffl ower (Carthamus tinctorius L.) 184 7.2.7 Linseed (Linum usitatissimum L.) 185 7.3 Spice Seeds as Medicine 185 7.3.1 Coriander seeds (Coriandrum satium L.) 185 7.3.2 Caraway (Cumin carvi L.) 186 7.3.3 Pepper seeds (Piper nigrum L.) 186 7.3.4 Cumin seeds (Cuminum cyminum L.) 186 7.3.5 Fenugreek seeds (Trigonella foenum-graecum L.) 187 7.4 Legumes and Medicinal Use 187 7.4.1 Soybeans (Glycine max (L.) Merrill) 187 7.4.2 Mucuna pruriens L. 188 7.4.3 Tamarind seeds (Tamaridus indica L.) 188 7.5 Underutilized Seeds 189 7.5.1 Perilla (Perilla frutescens [Hassk.]) 189 7.5.2 Hunteria umbellata ([K. Schum] Hallier f.) 189 7.5.3 Microula sikkimensis (Hemsl.) 189 7.5.4 Chinese chive seeds (Allium tuberosum Rottl.) 190 7.5.5 Grape seeds (Vitis vinifera L.) 190 7.5.6 Pumpkin seeds (Cucurbita sp.) 191 7.5.7 Horse chestnut seeds (Aesculus hippocastanum L.) 192 7.6 Future Outlook 192 References 193 8 Effects of Carotenoids and Retinoids on Immune-Mediated Chronic Inflammation in Infl ammatory Bowel Disease 213 Hua Zhang, Ming Fan, and Gopinadhan Paliyath 8.1 Introduction 213 8.2 Carotenoids 213 8.3 IBDs 214 8.4 Phytochemicals and Downregulation of IBD 215 8.4.1 Antioxidative capacity of carotenoids to reduce oxidative stress generated from inflammation 215 8.4.2 Immune-modulating activity of carotenoids 216 8.5 Effects of Carotenoids on Immune Genetic Mechanism of IBD 221 8.5.1 Potential role of retinoid receptors in attenuation of inflammatory diseases 222 8.5.2 Modulation of inflammatory responses through activation of nuclear receptors containing RXR heterodimers 223 8.6 Effects of Retinoids and Carotenoids on the Oxidative Stress Signaling Pathway 226 References 229 9 Ruminant Trans Fat as Potential Nutraceutical Components to Prevent Cancer and Cardiovascular Disease 235 Ye Wang, Catherine J. Field, and Spencer D. Proctor 9.1 Introduction 235 9.2 c9,t11-CLA Isomer and Health Implications 237 9.2.1 CLA modulates carcinogenesis 237 9.3 Mechanisms of CLA Action on Cancer 245 9.4 CLA Modulates CHD Risk Factors 245 9.5 Mechanisms of CLA Action on CHD 246 9.6 Vaccenic Acid 252 9.6.1 VA modulates carcinogenesis 253 9.6.2 VA modulates CVD risk factors 253 9.7 Dairy Fat Enriched with VA and CLA 254 9.7.1 Enriched dairy fat modulates carcinogenesis 254 9.7.2 Enriched dairy fat modulates CVD risk factors 255 9.8 Discussion 255 References 256 10 Nanotechnology for Cerebral Delivery of Nutraceuticals for the Treatment of Neurodegenerative Diseases 263 Jasjeet Kaur Sahni, Sihem Doggui, Lé Dao, and Charles Ramassamy 10.1 Introduction 263 10.2 Oxidative Stress in Mild Cognitive Impairment (MCI) and AD 264 10.3 Efficacy of Selected Components of Nutraceutical Compounds in the Amyloid Cascade and in the Prevention of AD 266 10.4 Targeted NPs for Delivery of Bioactives Compounds from Foods for the Treatment of AD 272 10.4.1 Catechins coupled with NPs 272 10.4.2 NPs targeted with ApoE containing curcumin 273 10.4.3 Resveratrol-loaded NPs protect againt Aß-induced toxicity 275 10.5 Conclusion 275 References 275 11 Cancer Prevention by Polyphenols: Influence on Signal Transduction and Gene Expression 285 Fatima Hakimuddin and Gopinadhan Paliyath 11.1 Introduction 285 11.2 Genetic Mechanisms of Carcinogenesis 285 11.3 Biochemical Mechanisms of Carcinogenesis 287 11.3.1 Pathways and signals involved in neoplastic cell transformation and carcinogenesis 287 11.3.2 Extracellular signal transduction 288 11.3.3 Intracellular signal transduction 289 11.4 Signaling Pathways in Breast Cancer 291 11.4.1 Calcium homeostasis and signaling 292 11.4.2 Role of calcium in regulating cell proliferation and cell cycle 293 11.4.3 Regulation of the cell cycle by calmodulin 293 11.4.4 Calcium signaling and cell death 293 11.4.5 Mitochondria, calcium signaling, and apoptosis 294 11.5 Cancer Prevention and Therapy 294 11.5.1 Targeted therapies 294 11.5.2 Phytochemicals and cancer prevention 296 11.6 Grapes and Red Wine as a Dietary Source of Polyphenols 298 11.6.1 Health benefi ts of red wine 298 11.6.2 Modulation of signaling pathways by fl avonoids 306 11.7 Genetic Approach: Identifi cation of Flavonoid Mediated Molecular Targets 308 11.8 Estrogen Metabolism, Breast Cancer, and Flavonoids 311 11.9 Polyphenols and Estrogen Signaling 312 References 313 12 Potato–Herb Synergies as Food Designs for Hyperglycemia and Hypertension Management 325 Fahad Saleem, Ali Hussein Eid, and Kalidas Shetty 12.1 Introduction 325 12.2 Phenolic-Enriched Chilean Potato and Select Species of Apiaceae and Lamiaceae Families in Diet 327 12.3 Combination of Potato with Seeds and/or Herbs for Hypertension and Hyperglycemia Management 331 12.3.1 Chilean potato (Solanum tuberosum ssp. tubersocum L.) 331 12.3.2 Apiaceae family 333 12.3.3 Lamiaceae family 335 12.4 Conclusions: Combining the Chilean Potato with Seeds and Herbs from the Apiaceae and Lamiaceae Families 336 References 338 13 Fermentation-Based Processing of Food Botanicals for Mobilization of Phenolic Phytochemicals for Type 2 Diabetes Management 341 Chandrakant Ankolekar and Kalidas Shetty 13.1 Introduction 341 13.2 Diabetes: The Rising Burden 342 13.3 Fermentation and Health: A Historical Perspective 342 13.4 Fermentation: Adding Value 343 13.4.1 Preservation of food through acid/alcohol formation 343 13.4.2 Enrichment of food substrates through formation of micro and macro nutrients 344 13.4.3 Flavor, aroma, and texture development 344 13.4.4 Detoxification of substrates during fermentation 345 13.5 Phenolic Antioxidants and Diabetes Management 345 13.6 Microbial Aerobic Growth and Fermentation and Its Anti-Diabetes Potential by Phenolic and Antioxidant Mobilization 346 13.6.1 Solid State Growth (SSG) 346 13.6.2 Liquid state (submerged) fermentation 347 13.7 Fruit Juice Fermentation for Healthy Food Ingredients for Management of Type 2 Diabetes 348 13.7.1 Apple juice fermentation 348 13.7.2 Pear juice fermentation 349 13.7.3 Cherry juice fermentation 349 13.8 Summary 350 References 351 14 Postharvest Strategies to Enhance Bioactive Ingredients for Type 2 Diabetes Management and Heart Health 357 Dipayan Sarkar and Kalidas Shetty 14.1 Introduction 357 14.2 Changing Dietary Patterns: A Historical Perspective 357 14.3 Noncommunicable Chronic Diseases: Era of New Global Epidemics 358 14.4 Healthy Diet: “Prevention Is Better Than Cure” 360 14.4.1 Fruits and vegetables: from garden of eden to modern horticulture 360 14.5 Bioactive Ingredients 361 14.6 Dietary Polyphenols: Impact on Human Health 362 14.6.1 Role of polyphenols in glucose metabolism 362 14.6.2 Polyphenols and cardiovascular disease 364 14.7 Phenolic Biosynthesis: Biological Mechanism to Improve Dietary Polyphenols in Plant Models 365 14.8 Postharvest Strategies to Improve Bioactive Ingredients in Fruits and Vegetables 367 14.8.1 Temperature 367 14.8.2 Light and oxygen 368 14.8.3 Chemical treatment and natural compounds 368 14.9 Phenolic-Linked Antioxidant Activity During Postharvest Stages in Fruits and Relevance for Type 2 Diabetes 369 14.10 Future Direction of Research: When Functional Food and Diet Become “Panacea” 370 14.10.1 Stage 1: physiology and growth during germination to maturity 370 14.10.2 Stage 2: postharvest management 371 14.10.3 Stage 3: food processing 371 14.10.4 Stage 4: biotechnological tools 372 14.10.5 Stage 5: in vitro studies 372 14.10.6 Stage 6: animal, clinical, and epidemiological studies 372 14.10.7 Stage 7: marketing, awareness, and education 373 14.11 Conclusions 373 References 373 15 Enhancing Functional Food Ingredients in Fruits and Vegetables 381 Shaila Wadud and Gopinadhan Paliyath 15.1 Introduction 381 15.2 Strategies for Nutritional Enhancement 382 15.3 Improving the Mineral Content of Plant Foods 383 15.3.1 Iron and zinc 384 15.4 Improving the Antioxidants Content of Plant Foods 385 15.4.1 Lycopene and ß-carotene 385 15.4.2 Vitamin E 387 15.4.3 Flavonoids 387 15.5 Improving the Amino Acid Content of Proteins of Plant Foods 389 15.6 Improving the Fatty Acid Composition of Plant Seed Oil 390 15.7 Influence of Processing and Storage in the Nutritive Value of Plant Foods 391 15.7.1 Processing of plant oils 391 15.7.2 Processing of fruits and vegetables 391 References 392 Index 395
£190.90
