Diseases and disorders Books

Book SynopsisDas Referenzwerk zur pädiatrischen Pneumologie wurde von einem neuen Herausgeberteam grundlegend überarbeitet. Spezialisten aus Deutschland, Österreich und der Schweiz haben bei diesem umfassenden Praxisbuch mitgewirkt, das sich an dem European Training Syllabus der European Academy of Paediatrics orientiert. Lückenlos präsentiert das Buch das fundierte Spezialwissen zu Atemwegserkrankungen bei Kindern und Jugendlichen von den respiratorischen Erkrankungen des Früh- und Neugeborenen bis hin zu Asthma, obstruktiven Atemwegserkrankungen, Pneumonie und seltenen Lungenerkrankungen. Der Bogen wird gespannt von den verständlich dargestellten Grundlagen des gesunden Respirationstraktes über die diagnostischen Techniken bis hin zu den Erkrankungen des Respirationstraktes, die nach einer einheitlichen Struktur ausführlich und praxisnah beschrieben sind.Spezielle Therapien wie Inhalationstherapie oder Heimbeatmung bilden einen weiteren Schwerpunkt des Buches. Das wichtige Thema der Interaktionen mit anderen Fachgebieten wurde neu ins Buch aufgenommen, darunter intensivmedizinische Aspekte, Difficult Airway Management oder kinderchirurgische Aspekte. Damit ist dieses Referenzwerk für alle Ärzte nützlich, die mit pädiatrischer Pneumologie in Berührung kommen. Zum Lesen, Lernen und Nachschlagen.Trade ReviewAus den Rezensionen: “... Das Stichwortverzeichnis ist ungewöhnlich gut und ausführlich. ... Das Buch ist jedem klinisch Tätigen und verantwortungsbewussten Kinderarzt zu empfehlen, außerdem ist es das Nachschlagewerk für alle Kinderpneumologen und Spezialisten, die auf diesem wichtigen Arbeitsgebiet der Kinderheilkunde und Jugendmedizin arbeiten.“ (W.Kiess, in: Kinder- und Jugendmedizin, Heft 3, 2014)Table of ContentsI Der gesunde Respirationstrakt1 Strukturelle Entwicklung, Embriologie.- 2 Funktionelle Entwicklung der Lunge (Mechanik, Gasaustausch).- 3 Angewandte Physiologie.- 4 Physiologie des Schlafs und Atemregulation5 Abwehr.- 6 Umweltfaktoren.- 7 Genetik.- 8 EpidemiologieII Diagnostik9 Anamnese.- 10 Klinische Untersuchung.- 11 Lungenfunktionsdiagnostik.- 12 Bronchoskopie13 Bildgebung.- 14 Schlafuntersuchungen.- 15 Ziliendiagnostik.- 16 Gastro-ösophagealer Reflux17 Mikrobiologische Untersuchungstechniken.- 18 Allergologische Techniken.- 19 Immunologische Techniken .- 20 CFTR-Funktionstechniken.- 21 Genetische Diagnostik22 Techniken der Pleurapunktion, Drainagen, Thorakosopie, VATS, LungenbiopsieIII Erkrankungen des Respirationstraktes23 Respiratorische Erkrankungen des Früh- und Neugeborenen.- 24 Angeborene Lungenerkrankungen.- 25 Erkrankungen des pulmonalen Gefäßsystems.- 26 Infektionen.- 27 Obstruktive Atemwegserkrankungen.- 28 Cystische Fibrose.- 29 Bronchieektasen.- 30 PCD.- 31 Seltene Lungenerkrankungen.- 32 Lungentransplantation.- 33 Pädiatrisch-pneumologische Aspekte der Schlafmedizin.- 34 Psychogene und funktionelle Atemstörungen.- 35 Fremdkörperaspiration.- 36 Pleuraerguss, Pneumothorax, Chylothorax, HamatothoraxIV Spezielle Therapien37 Physiotherapie.- 38 Inhalationstherapie.- 39 Spez. Immuntherapie und Management der Anaphylaxie.- 40 Langzeitbetreuung bei chronischen Lungenerkrankungen.- 41 Schulungsprogramme42 Rehabilitation.- 43 Schmerztherapie.- 44 Palliativmedizinische AspekteV Interaktionen mit anderen Fachgebieten45 Intensivmedizinische Aspekte.- 46 Kinderchirurgische Aspekte der Pädiatrischen PneumlogieVI Abklärung klinischer Zeichen und Symptome47 Husten.- 48 Giemen. -49 Dyspnoe/ Tachypnoe.- 50 Verdacht auf zentrale Apnoen.- 51 Stridor52 Schnarchen.- 53 Heiserkeit.- 54 Thoraxschmerz.- 55 ZyanoseVII Anhang56 Weiterbildungskatalog (Dt,CH, Au, Europa).- 57 Online-Weiterbildung.- 58 Wichtige Homepages und Fachgesellschaften

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Book SynopsisKurz vor einer Prüfung gerät man schnell mal unter Zeitdruck. Und die besten Lernpläne schützen nicht vor dem Gefühl, sich doch nicht richtig vorbereitet zu haben.„Innere Medizin“ gehört hier zu den ganz großen Brocken! Eine Menge Stoff, haufenweise Fragen im Examen, Grundlagenwissen für viele andere Fachgebiete – wer da nicht ins straucheln kommt…Glückwunsch.Gut, wenn man aber auf ein Buch zurückgreifen kann, das dank einer durchdachten Gliederung und sinnvoll gewichtetem Inhalt optimal durch die Prüfungsvorbereitung führt.„Innere Medizin… in 5 Tagen“ punktet durch: Praktische Relevanz Hinweise auf typische IMPP Fragen Klare Gliederung Verständlichkeit KürzeDas Werk ist nicht nur als Repetitorium kurz vor einer Prüfung geeignet, sondern auch als vorlesungsbegleitendes Kurzlehrbuch.In der 3. Auflage wurden alle Kapitel sorgfältig überarbeitet und aktualisiert.Trade ReviewAus den Rezensionen:“... ist nicht nur gut zur Vorbereitung auf das zweite Staatsexamen geeignet,sondern stellt auch für den gesamten klinischen Abschnitt des Medizinstudiums eine hervorragende und wichtige Hilfe dar ... eignet sich das Buch sehr gut zum Lernen und ist empfehlenswert. ... Verständlichkeit und Hinweise auf typische IMPP-Fragen begleiten optimal durch die Prüfungsvorbereitung ...“ (Veronika Gebhardt, in: webcritics.de, 6. November 2014) “... Das Buch ist im Kurzlehrbuchstil gehalten und beinhaltet alle wichtigen Erkrankungen der Inneren Medizin, die in stichpunktartiger Form abgehandelt werden. Das Konzept des Buches beruht darauf, das komplette examensrelevante Wissen in 5 Tagen zu lernen. ... Die einzelnen Krankheitsbilder werden zunächst kurz beschrieben und weiterhin in Klinik, Diagnostik und Therapie unterteilt. ... ist die Sprache leicht verständlich und gut zu lesen und die Einteilung in verschiedene Lerntage macht die Organisation der Lernzeit einfacher und übersichtlicher ...“ (in: Fachschaft Medizin Münster, fsmed-muenster.de, 1.Dezember.2014)“... Die Stichpunkte sind immer sehr gut verständlich und an geeigneten Stellen eher satz- bzw. textartig gestaltet. ... Stadien und Klassifikationen werden zudem in Lerntabellen aufgeführt, aber auch im sonstigen Text erläutert ...“ (in: FiMM Fachschaftsinitiative Medizin Mannheim FiMM-online.de, September 2014)Table of ContentsTag 1: Kardiologie und Angiologie.- Tag2: Pneumologie und Infektiologie.- Tag 3: Gastroenterologie und Stoffwechsel.- Tag 4: Hämatologie und Rheumatologie.- Tag 5: Nephrologie und Endokrinologie.

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Book SynopsisTable of ContentsInhaltsangabe.- I. Biologischer Teil.- Physikalische und chemische Vorbemerkungen.- Chemische Wirkungen der radioaktiven Substanzen.- Einfluß der radioaktiven Substanzen auf Fermente.- Einwirkung der Becquerelstrahlen auf pflanzliche Organismen.- Einwirkung der Becquerelstrahlen auf niedere tierische Organismen.- Biologische Wirkungen der radioaktiven Substanzen bei höheren tierischen Organismen.- A. Durch lokale äußere Bestrahlung.- B. Durch Einverleibung.- Applikation und Dosierung der radioaktiven Substanzen.- 1. Beeinflussung des blutbildenden Apparats.- 2. Wirkung auf Herz und Gefäßsystem und auf das chromaffine Gewebe.- 3. Beeinflussung der Atemorgane.- 4. Beeinflussung des Magen-Darmtraktus.- 5. Wirkungen auf die Nieren.- 6. Einwirkung auf die Haut.- 7. Einfluß auf die Keimdrüsen.- 8. Wirkung der radioaktiven Substanzen auf den Stoffwechsel.- 9. Einfluß auf das Nervensystem.- Theoretische Schlußbetrachtungen.- II. Klinischer Teil.- Therapeutische Anwendungsformen.- Allgemeine Gesichtspunkte bei der Indikationsstellung.- I. Gelenkerkrankungen.- II. Erkrankungen des Nervensystems.- III. Erkrankungen der Muskeln.- IV. Erkrankungen des Nasen-Rachenraumes und des Respirationstraktus..- V. Erkrankungen des Herzens und der Gefäße.- VI. Erkrankungen des Intestinaltraktus.- VII. Erkrankungen der Nieren und der Blase.- VIII. Stoffwechselkrankheiten.- IX. Erkrankungen des blutbildenden Apparates.- X. Karzinome und Sarkome.- XI. Erkrankungen der Blutdrüsen.- Literatur.

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Book SynopsisDieses Buch enthält wertvolle praktische Anleitungen und Tipps für die PJ-Tertiale Innere und Chirurgie und bereitet optimal auf das mündliche Staatsexamen vor. Von A wie Anamnese bis Z wie Zugänge legen werden alle Schritte und Handgriffe mit vielen Bildern und kurzen Texten erklärt. Auch schon für die Famulatur ist dieses Buch eine große Hilfe. So können Sie sich ideal auf die Zeit in Praxis und Klinik vorbereiten und wissen Bescheid, wenn Sie beim Patienten sind oder mit Kollegen zusammen arbeiten. Neben der Beschreibung der praktischen Handgriffe bietet das Buch außerdem:• Checklisten – Welches Material benötige ich wofür?• Merksätze – Was sind die Dos and Don´ts?• Zwischenmenschliches – Dinge, die sonst nicht im Lehrbuch stehen.Der HerausgeberDr. Carl Meißner ist Allgemeinchirurg in der Allgemein- und Viszeralchirurgie am Klinikum Magdeburg. Sein PJ ist noch nicht so lange her und er weiß noch sehr genau, welches Handwerkszeug ein junger PJler braucht.Table of ContentsAnamnese und klinische Untersuchung.- Hygiene.- Chirurgische Instrumentenlehre.- Die Visite.- Atemwege.- Zugänge und Katheter.- Diagnostische Punktion (Aszites, Pleura und Kniegelenk).- Im Operationssaal.- Wundbehandlung (Wundversorgung und Wundbeurteilung).- Notfall im klinischen Alltag.- Durchführung und Bewertung internistischer Diagnoseverfahren.- Diagnostik und Beurteilung im Notfall.- Wissenswertes zur Anamnese und Untersuchung.- Anhang.

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Book SynopsisDieses handliche Kitteltaschenbuch vermittelt anhand von zahlreichen Übersichten, Tabellen und stichwortartigen Fakten absolutes Praxiswissen für den Berufsalltag von Anästhesisten. Gespickt mit vielen Hinweisen zum ganz konkreten Vorgehen sowie auf Fallstricke, Gefahrensituationen und Besonderheiten, bietet es vor allem dem Berufsanfänger in der Anästhesiologie das nötige Wissen, um sowohl bei Erwachsenen als auch bei Kindern eine sichere Anästhesie, Analgesie oder Sedierung durchzuführen. Table of Contents1. Allgemeinanästhesie.- 2.Regionalanästhesie.- 3.Analgosedierung.- 4. Kinderanästhesie.- 5. Arbeitstechniken.-6. Medikamente.- 7. Anästhesie bei Begleiterkrankungen.- 8. Anästhesie in der Allgemein-, Viszeral- und Transplantationschirurgie.- 9. Postanästhesiologisches Management.

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Book SynopsisEinteilung der Antibiotika.- Generika - Handelsnamen.- Handelsnamen. - Generika.- Leitsätze der Antibiotika.- Häufigste Fehler bei der Antibiotikatherapie.- Wichtige Infektionen - wichtige mikrobiologische Diagnostik.- Zusammenarbeit mit Mikrobiologen.- Resistenz klinisch wichtiger Erreger.- Häufigste Erreger - Antibiotikaauswahl.- Antibiotika, Antimykotika: Spektrum Dosierung Nebenwirkungen Kosten.- Antibiotikatherapie der wichtigsten Infektionen bei Kindern und Erwachsenen.- Therapie der häufigsten bakteriellen Endokarditiden.- Mindestbehandlungsdauer von bakteriellen Infektionen.- Versagen der Antibiotikatherapie.- Differentialdiagnose, Fieber unklarer Genese.- Dosierung von Antibiotika bei eingeschränkter Nierenfunktion.- Antibiotikatherapie bei Hämodialyse, Peritonealdialyse und kontinuierlicher Hämofiltration.- Antibiotikatherapie in der Schwangerschaft und Stillzeit.- Antibiotika bei Lebererkrankungen.- Diffusion von Antibioti

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Table of ContentsCanine Distemper Virus.- Marburg Virus.

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Book SynopsisCon una larga trayectoria de 11 ediciones, Werner & Ingbar. Tiroides ha sido la referencia por excelencia para la cobertura más completa sobre la tiroides. La obra aborda anatomía, desarrollo embrionario, bioquímica, fisiología, fisiopatología, diagnóstico y tratamiento de todos los padecimientos que afectan a la tiroides y de esta forma se convierte en la fuente de información más autorizada sobre el diagnóstico y tratamiento de la glándula tiroidea para médicos endocrinólogos y cirujanos de tiroides.Esta 11.ª edición se encuentra completamente actualizada e incluye nuevo contenido en histopatología e imagen diagnóstica y terapia dirigida para el cáncer de tiroides. La obra se divide en ocho secciones que abarcan los fundamentos (morfología, bioquímica y fisiología), diagnóstico y evaluación de la función tiroidea, tirotoxicosis o hipertiroidismo, hipotiroidismo, bocio, cáncer y clínica de la tiroides en grupos especiales (niñez y embarazo).

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Book SynopsisThis volume is characterised by coloured figures/illustrations and a multimedia area. The textbook, entirely written by Italian academic gastroenterologists, is primarily addressed to medical students attending the different Integrated Courses of Medicine and Surgery, who are preparing the test for passing the exam of Gastroenterology. The present volume has been updated and enriched in order to offer a user-friendly tool to learn basic and clinical Gastroenterology, always in line with the most recent research and pedagogical methodologies.

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Book SynopsisLeprosy (Hansen’s disease) is an infectious disease caused by Mycobacterium leprae. It is one of the most disabling disorders in developing countries, with a peak incidence in the tropics and subtropics. With globalization, leprosy is now increasingly spreading to the western world. The impact of this infectious disorder is relevant for the human community due to its transmissible nature, and also important for the individual because of its debilitating consequences. Leprosy is a multifaceted systemic disease with variable presentation and clinical picture. Its identification may therefore not be straightforward, especially outside endemic areas. During its chronic course, leprosy is characterized by acute phases during which there may be exacerbation of symptoms and rapid progression of damage. When leprosy affects the eyes, nerves, and kidneys, it can represent a true medical emergency. The aim of this book is to make the reader familiar with the characteristic signs of disease, including abnormalities of the skin, nerves, eyes, hands, feet, testes, and bone. Early identification of the disease is critical to prevent patient disability and establish appropriate therapy. Emphasis will be given to the current diagnostic tools to identify and quantify the organ damage, including electrophysiology, ultrasonography, magnetic resonance imaging, laboratory tests, and histopathology. Specific topics such as leprosy and pregnancy, leprosy and HIV infection, epidemiology, and leprosy control will also be covered.Table of ContentsI GENERAL SECTION: 1 History, Coppelman (Paris, France). 2 Microbiology, Clappason (Genova, Italy). 3 Genetics, Fava, Mira (Curitiba, Brazil). 4 Immunology, Ribeiro (Victoria, Brazil). 5 Pathophysiology, Nunzi, Massone (Genova, Italy). 6 Classifications, Nunzi, Massone (Genova, Italy).- II CLINICAL EXAMINATION: 7 Patient’s History, Nunzi (Genova, Italy). 8 Physical examination: Skin, Nunzi (Genova, Italy). 9 Physical examination: Nerves, Reni, Noto (Genova, Italy).- III SKIN: 10 Clinical Features, Nunzi (Genova, Italy). 10 Histopathology, Massone (Genova, Italy). 11 Differential Diagnosis, Nunzi (Genova, Italy).- IV LEPROSY REACTIONS: 12 Naafs, Noto (Leiden, The Netherlands; Genova, Italy). 13 Lucio Leprosy, Magana (Mexico City, Mexico).- V NERVES: 14 Clinical Features, Reni, Noto (Genova, Italy). 15 Differential Diagnosis, Reni, Noto (Genova, Italy). 16 Disability, Brandsma (Nepal). 17 Neurophysiology, Reni (Genova, Italy). 18 Imaging, Martinoli (Genova, Italy).- VI OTHER ORGAN INVOLVEMENT: 19 Eyes, Nunzi (Genova, Italy). 20 ORL, Talhari A, Talhari S. 21Other Organs, Nunzi (Genova, Italy).- VII MANAGEMENT OF PATIENTS: 22 Diagnostic Work-up, Nunzi (Genova, Italy). 23 Drugs in Leprosy: Pharmacology, Pharmacokinetics, Side Effects, Talhari S (Manaus, Brazil). 24 Medical Therapy, Bobin (Bordeaux, France). 25 Surgical Therapy, Gennaro (Genova, Italy). 26 Rehabilitation, Brandsma (Nepal).- VIII LEPROSY AND COMMUNITY: 27 Epidemiology, Noto (Genova, Italy). 28 Leprosy Control, Deepak (Bologna, Italy). 29 TeleDermatology, Massone, Schettini, Soyer, (Brisbane, Australia, Manaus, Brazil, Graz, Austria). 30 Leprosy in Pregnancy, Massone. 31 Leprosy in HIV, Talhari C, Talhari S (Manaus, Brazil)

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Book SynopsisKinderfysiotherapie en spasticiteit.- Psychometrische verantwoording van metingen.- Meten van spiertonus.- Tonusonderzoek van Amiel-Tison.- Fysiotherapie als hulpverlening aan kinderen.- Betrouwbaarheidsonderzoek van het bewerkte tonusonderzoek.

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Book Synopsis‘The story of oncology is not only fascinating but also contains many accounts of dead ends, chance discoveries, illusions, mistakes and disappointments alongside the few successes.’These words are taken from the introduction to this book. The author, professor emeritus of Medical Oncology, reviews all aspects of the problem of cancer from a historical perspective, from the oldest existing records to the latest scientific and medical advances. It will interest the many people engaged in the treatment of cancer to read how the current therapeutic methods came about, and the book may also provide inspiration for cancer researchers, and for all those directly or indirectly involved with cancer. The layman looking for background information on a particular treatment may find it useful too. The various chapters can be read independently. A glossary and a few explanatory diagrams augment the text.This book grew out of an invitation the author received to lecture on the history of oncology. During his background reading, he discovered that there was no single volume dealing with the entire history of the subject. Fortunately, however, a great deal of information could be found here and there in the literature. As he read, he was struck by the fascinating stories behind many discoveries, and felt impelled to put them together in a single comprehensive account. The results of his labors are presented in this remarkable volume.The author, Prof. D.J.Th. (Theo) Wagener, was head of the department of Medical Oncology at the Radboud University Nijmegen Medical Centre in the Netherlands from 1982 to 2001, chairman of the Educational Committee of the European Society of Medical Oncology (ESMO), a member of the Educational Committee of the American Society of Clinical Oncology (ASCO) and a member of various international scientific working groups, mainly of the European Organization for Research and Treatment of Cancer (EORTC).Table of Contents1. Introduction.- 2. The occurrence of cancer in ancient times and the development of ideas about the nature of the complaint.- 3. The treatment of cancer in the past.- 4. The maturing of surgery as a treatment for cancer.- 5. The historical development of radiotherapy.- 6. The development of chemotherapy.- 7. The history of the hormonal treatment of cancer.- 8. The background of targeted therapy and the emergence of a new approach.- 9. Immunotherapy in the past and the present.- 10. The origins of psycho-oncology.

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Book SynopsisWhen new fellows join my lab, I give them some reading materials so that they can orient themselves in their assignment in a new eld. When fellows leave my lab, some after writing their dissertations, I prefer to give them a book as a symbolic present. I was longing for a book that contained something on more or less eve- thing about the islets. At the same time, I wished it contained information as recent as possible. There are a few such books in the market but they are pretty outdated. I started picking islets myself from October 1990, when I joined the Rolf Luft Center, Karolinska Institutet. Over the years my fascination for islet research remained high. Since last year, I felt a stronger urge to do more for these mysterious and hidden mini-organs that are directly or indirectly involved in the pathogenesis of all forms of diabetes that affects ?250 million people in the world. After I launched the Islet (landesbioscience. com/journals/islets) and founded the Islet Society (isletso- ety. org), there was a momentum that could be utilized to create something equally meaningful i. e. this book. The idea cracked in September 2008. Starting September 19, 2008, I contacted an estimated 90% of the authors who published anything on the islets during 2007–2008 and who could be traced from the internet.Trade Review"It looks very comprehensive and covers all current areas of interest and includes chapters written by world renowned contributors - very nice!"Matthias von Herrath, MDProfessor and Director, Center for Type 1 Diabetes ResearchLa Jolla Institute for Allergy and Immunology, La Jolla CA, USA "This book will be welcomed by islet researchers and clinicians interested in the latest developments and theories from which new therapeutics for diabetes can emerge". Martha Pavlakis, MDAssociate Professor of Medicine, Harvard Medical SchoolMedical Director, Kidney and Pancreas TransplantationBeth Israel Deaconess Medical CenterBoston, MA, USA "The field of islet biology is assuming increasing importance with the recognition that beta-cell dysfunction is a critical feature of type II diabetes. Improving b-cell function and/or b-cell mass may be the best approach to treating diabetes. Thus, the publication of a book covering so many aspects of this field is timely". Fred Levine, M.D., Ph.D.Professor, Burnham Institute for Medical ResearchDirector, Sanford Children's Health Research CenterLa Jolla, CA, USA "The growing prevalence of both type 1 and type 2 diabetes make islet cell biology a critical concern for a wide range of scientists and health professionals. From anatomy and developmental biology, through islet physiology and biochemistry, to issues of immunology and transplantation, this book is a terrific resource".Jonathan M.W.Slack, Ph.D., F.Med.Sci. Director, Stem Cell Institute, University of Minnesota, Medical SchoolMinneapolis, MN, USA "This book allows you to enjoy an adventurous and instructive guided tour in the archipelago of the islets of Langerhans. A team of expert and enthusiastic explorers will not only conduct the voyager through almost all niches of this complex and fascinating environment, but also provide him with clues and keys for future exploration of still hidden sites".Prof. Pellegrino MasielloDept. of Experimental Pathology,University of Pisa,Pisa, Italy "The pancreatic islet is a complex mini-organ whose dysfunction is critical in all forms of diabetes. This book provides a comprehensive review of the molecular and cellular processes in islet development, gene expression, and physiology and reviews how a better understanding of the pancreatic islet will advance efforts to develop new therapeutic approaches for diabetes. This book should be quite useful for anyone interested in the pancreatic islet or diabetes".Alvin C. Powers, M.D.Joe C. Davis Chair in Biomedical Science Professor of Medicine, Molecular Physiology and BiophysicsDirector, Vanderbilt Diabetes CenterVanderbilt UniversityNashville, TN USA "A very timely book on the Islet of Langerhans that coincides with the realization that pancreatic ß-cell failure is key to all forms of diabetes mellitus and research in the field is exploding. It contains very thoughtful chapters, each by renown experts in their field, and tackles the complexity of this micro-organ in health and disease very comprehensively and thoughtfully. It will likely become a Reference for years to come for basic researchers, clinicians and students interested is diabetes research"Marc Prentki, PhDProfessor of Nutrition and BiochemistryCanada Research Chair in Diabetes and MetabolismMDRC DirectorMontreal, QCCanada Table of ContentsCHAPTER 1 : Microscopic anatomy of the human islet of Langerhans - Peter In't Veld and Miriam Marichal CHAPTER 2 : The comparative anatomy of islets - Scott Heller CHAPTER 3: Approaches for imaging of islets: recent advances and future prospects - Ulf Ahlgren and Martin Gotthardt CHAPTER 4: Islet-cell Development - Anabel Rojas, Adrian Khoo, Juan R. Tejedo, Francisco J. Bedoya, Bernat Soria and Franz Martín CHAPTER 5: High fat programming of b-cell failure - Marlon. E. Cerf CHAPTER 6: Nutrient regulation of insulin secretion and b-cell functional integrity - Philip Newsholme, Celine Gaudel, and Neville H McClenaghan CHAPTER 7: Electrophysiology of islet cells - Gisela Drews, Peter Krippeit-Drews and Martina Düfer CHAPTER 8: ATP sensitive potassium channels in health and disease - Rebecca Clark and Peter Proks CHAPTER 9: Role of mitochondria in b-cell function and dysfunction - Pierre Maechler, Ning Li, Marina Casimir, Laurène Vetterli, Francesca Frigerio, Thierry Brun CHAPTER 10: Basement membrane in pancreatic islet function - Martin Kragl and Eckhard Lammert CHAPTER 11: Calcium signaling in the islets - Md. Shahidul Islam CHAPTER 12: Electrical bursting, calcium oscillations, and synchronization of pancreatic islets - Richard Bertram, Arthur Sherman, and Leslie S. Satin CHAPTER 13: Cyclic AMP signaling in pancreatic islets - Brian Furman, Wee Kiat Ong, and Nigel Pyne CHAPTER 14: Exocytosis in islet b-cells - Haruo Kasai, Hiroyasu Hatakeyama, Mitsuyo Ohno and Noriko Takahashi CHAPTER 15: The novel roles of glucagon-like peptide-1, angiotensin II, and vitamin D in islet function - Po Sing Leung CHAPTER 16: Proteomics and islets research - Meftun Ahmed CHAPTER 17: Wnt signaling in pancreatic islets - Zhengyu Liu and Joel F. Habener CHAPTER 18: Molecular pathways underlying the pathogenesis of pancreatic a-cell dysfunction - Dan Kawamori,Hannah J. Welters, and Rohit N. Kulkarni CHAPTER 19: Mechanisms of pancreatic b-cell apoptosis in diabetes and its therapies - James D. Johnson, Dan S. Luciani CHAPTER 20: b-cell function in obese-hyperglycaemic mice [ob/ob mice] - Per Lindström CHAPTER 21: Islet structure and function in the GK rat - B. Portha, G. Lacraz, A. Chavey, F. Figeac, M. Fradet, C. Tourrel-Cuzin, F. Homo-Delarche, M-H. Giroix, D. Bailbé, MN. Gangnerau, J. Movassat CHAPTER 22: The b-cell in human type 2 diabetes - Piero Marchetti, Roberto Lupi, Silvia Del Guerra, Marco Bugliani, Lorella Marselli and Ugo Boggi CHAPTER 23: Clinical approaches to preserve b-cell function in diabetes - Bernardo L. Wajchenberg CHAPTER 24: Immunology of b-cell destruction - Daria La Torre, and Åke Lenmark CHAPTER 25: Toll-like receptors and type 1 diabetes - Danny Zipris CHAPTER 26: Prevention of b-cell destruction in autoimmune diabetes: current approaches and future prospects - Saikiran K Sedimbi and Carani B Sanjeevi CHAPTER 27: In vivo regeneration of insulin-producing b-cell - Hee-Sook Jun CHAPTER 28: Customized cell-based treatment options to combat autoimmunity and restore b-cell function in Type I diabetes mellitus: current protocols and future perspectives - Fred Fändrich and Hendrik Ungefroren CHAPTER 29: The progammable cell of monocytic origin (PCMO): A potential adult stem/progenitor cell source for the generation of islet cells - Hendrik Ungefroren and Fred Fändrich CHAPTER 30: Islet isolation for clinical transplantation - Tatsuya Kin CHAPTER 31: Human islet autotransplantation: the trail thus far and the highway ahead - Martin Hermann, Raimund Margreiter and Paul Hengster CHAPTER 32: Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes - Lorenzo Piemonti, Luca G. Guidotti,

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Book SynopsisThis book is one of the first scientific publications that the subject food combines with genetics and genomics and information provides about new options for prevention and management of disease. This complex interplay between genes, food and environment is not only a fascinating new field of research but a new vital area for maintaining health and adequate healthcare. The book gives the most recent knowledge about the effects on chronic diseases such as neurological and cardio vascular disorders and a number of rare metabolic disorders such as phenylketonuria (PKU and coeliac disease. The meaning for pregnancy and the first years of life is prominently described. The situation in developing countries (India) is discussed with proposals for structural improvements. The authors have written their contributions on request of patient organisations who wish a scientific basis for health policy and action in this field. The book will be published under auspices of the World Alliance of Organisations for the Prevention of Birth Defects.

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Book SynopsisMultidrug-resistant tuberculosis: past, present and future Ivan Bastian and Franyoise Portaels Mycobacteriology Unit. Institute of Tropical Medicine. Antwerp. Belgium The Lord hath created medicines out of the earth and he that is wise will not abhor them. Ecclesiasticus 38:4, quoted by Selman Waksman when accepting the 1952 Nobel Prize for Medicine that was awarded for the discovery of the first effective antituberculosis drug. streptomycin. which was derived from the soil bacterium, Streptomyces grisells. 1. HISTORICAL PERSPECTIVE This book has been published at the close of the twentieth century when the medical profession and the general community are increasingly concerned about the threat of multidrug-resistant tuberculosis (MDRTB)[1. 2]. However, at this epoch, it is enlightening to move back from our immediate concerns about MDRTB 'hot spots' in Asia, South America, and the former Soviet Union [3], and to place our current predicament in an historical context. If the results of the global survey of antituberculosis drug resistance conducted by the World Health Organisation (WHO) and the International Union against Tuberculosis and Lung Disease (IUATLD) can be extrapolated, only 2. 2% of TB cases worldwide are due to multi drug­ resistant strains [3]. At the beginning of the 20th century, all TB cases were refractory to all available therapies. Great advances had been made during the 19th century in the understanding of the epidemiology and pathogenesis of TB, and in the diagnosis of the disease (reviewed in references 4-7).Table of Contents1. Introduction: Multidrug-resistant tuberculosis: past, present and future; I. Bastian, F. Portaels. 2. The epidemiology of multidrug-resistant tuberculosis in the United States and other established market economies; M. Moore, E. McCray, I.M. Onorato. 3. Epidemiology of multidrug-resistant tuberculosis in low- and middle-income countries; M.A. Espinal. 4. The interaction of human immunodeficiency virus and multidrug-resistant tuberculosis; E. McCray, I.M. Onorato. 5. Clinical mismanagement and other factors producing antituberculosis drug resistance; A. Pablos-Mendez, K. Lessnau. 6. The molecular mechanisms of drug resistance in mycobacterium tuberculosis; H.E. Takiff. 7. DOTS and multidrug-resistant tuberculosis; M.C. Raviglione. 8.Conventional methods for antimicrobial susceptibility testing of mycobacterium tuberculosis; L. Heifets. 9. Novel rapid antimicrobial susceptibility tests for mycobacterium tuberculosis; J.C. Palomino. 10. Pharmacology of the second-line antituberculosis drugs; C.A. Peloquin, B. Auclair. 11. Treatment of multidrug-resistant tuberculosis; M.D. Iseman, G.A. Huitt. 12. Treatment of multidrug resistant tuberculosis in developing countries; J. Crofton, A. van Deun. 13. Treatment outcome of multidrug-resistant tuberculosis; E.E. Telzak. 14. Chemoprophylaxis and BCG in contacts of multidrug resistant tuberculosis; R.A. Stapledon, R. Lumb, I.S. Lim. 15. Multidrug-resistant tuberculosis and the health care worker; D.M. Weinstock, K.A. Sepkowitz. 16. The development of new chemotherapeutics for multidrug-resistant tuberculosis; C.E. Barry. 17. Population dynamics and control of multidrug-resistant tuberculosis; C. Dye, B.G. Williams. 18. Administrative, engineering, and personal protective measures for controlling mycobacterium tuberculosis; C. Richards, W.R. Jarvis. 19. Making DOTS plus work; P.E. Farmer, S.S. Shin, J. Bayona, J.Y. Kim, J.J. Furin, J.G. Brenner.

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Book SynopsisDDDDDDDDDDDD Effective management logically follows accurate diagnosis. Such logic often is difficult to apply in practice. Absolute diagnostic accuracy may not be possible, particularly in the field of primary care, when management has to be on analysis of symptoms and on knowledge of the individual patient and family. This series follows that on Problems in Practice which was con­ cerned more with diagnosis in the widest sense and this series deals more definitively with general care and specific treatment of symp­ toms and diseases. Good management must include knowledge of the nature, course and outcome of the conditions, as well as prominent clinical features and assessment and investigations, but the em­ phasis is on what to do best for the patient. Family medical practitioners have particular difficu1ties and ad­ vantages in their work_ Because they often work in professional isolation in the community and deal with relatively small numbers of near-normal patients their experience with the more serious and more rare conditions is restricted. They find it difficult to remain up-to-date with medical advances and even more difficult to decide on the suitability and application of new and relatively untried methods compared with those that are 'old' and well proven. Their advantages are that because of long-term continuous care for their patients they have come to know them and their families FOREWORD well and are able to become familiar with the more common and less serious diseases of their communities.Trade Review`The information is clearly laid out and well presented. The need for patient education and information is implicit throughout the book.' Journal of the Institute of Health Education, Vol. 23 (3).Table of Contents1. Making a diagnosis in general practice.- 2. Immunization.- 3. Self-care.- 4. Respiratory tract infections.- 5. Urinary tract infection.- 6. Vaginal discharge and pelvic infection.- 7. Sexually transmitted diseases.- 8. Gastrointestinal infections.- 9. Hepatitis; AIDS.- 10. Central nervous system infections.- 11. The common infectious diseases.- 12. Skin infections.- 13. Imported infections.- 14. Good standards.

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Book SynopsisThe development of immunization has been one of the most striking features in the control of infectious disease in the twentieth century. This book takes into account the need for a simple, concise account of immunization procedures not only in the UK and USA but also in other countries, and to this end a special chapter on immunization in developing countries has been included. Following two introductory chapters, there are nine chapters on various diseases and the vaccines that have been developed to combat them. In each of these chapters, a short discussion of the epidemiology of the disease and the history of immunization against it is followed by a description of the vaccine, its efficacy, contraindications to its use and future developments. These are followed by four general chapters on vaccines for travel, vaccines for selective use, passive immunization and immunization in tropical environments and the book concludes with a chapter on the smallpox vaccination and one on new vaccines. The demand for this book follows the popularity of a series of articles on immunization which appeared in Update. These have been expanded and largely rewritten. I have drawn on many expert sources and have made an effort to provide a balanced and non-controversial opinion with a discussion of alternative procedures where indicated.Table of Contents1 Introduction.- 2 Vaccines and Schedules.- 3 Diphtheria.- 4 Tetanus.- 5 Whooping Cough.- 6 Poliomyelitis.- 7 Measles (Rubeola).- 8 Rubella.- 9 Tuberculosis.- 10 Vaccines for Selective Use.- Influenza.- Viral Hepatitis.- Mumps.- Meningococcal Meningitis.- Pneumococcal Infections.- Anthrax.- 11 Vaccination for Travel.- Cholera.- Yellow Fever.- Typhoid Fever.- Others.- 12 Immunization in Developing Countries.- 13 Passive Immunization.- 14 Smallpox (Variola).- 15 New Vaccines.

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Book SynopsisDDDDDDDDDDDD Effective management logically follows accurate diagnosis. Such logic often is difficult to apply in practice. Absolute diagnostic accuracy may not be possible, particularly in the field of primary care, when management has to be on analysis of symptoms and on knowledge of the individual patient and family. This series follows that on Problems in Practice which was con­ cerned more with diagnosis in the widest sense and this series deals more definitively with general care and specific treatment of symp­ toms and diseases. Good management must include knowledge of the nature, course and outcome of the conditions, as well as prominent clinical features and assessment and investigations, but the emphasis is on what to do best for the patient. Family medical practitioners have particular difficulties and advantages in their work. Because they often work in professional isolation in the community and deal with relatively small numbers of near-normal patients their experience with the more serious and more rare conditions is restricted. They find it difficult to remain up-to-date with medical advances and even more difficult to decide on the suitability and application of new and relatively untried methods compared with those that are 'old' and well proven. vii Their advantages are that because of long-term continuous care for their patients they have come to know them and their families well and are able to become familiar with the more common and less serious diseases of their communities.Table of Contents1. Introduction.- 2. The Pancreas.- 3. Thyroid Disease.- 4. The Parathyroid Gland and Calcium Metabolism.- 5. Endocrine Diseases of the Ovary and Breast.- 6. The Testis.- 7. Disorders of the Pituitary.- 8. Disorders of the Adrenal Gland.

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Book SynopsisTumours of the prostate are the commonest types of neoplasm in the male. Whilst the benign form is virtually a universal condition in the ageing male, malignant tumours rank amongst the top causes of cancer death. Despite the fact that the involvement of the testis in the growth of the prostate has been recognised for almost two centuries, it was not until the early 1940s that Charles Huggins' studies on the effect of orchidectomy and oestrogen therapy on prostatic cancer initiated endocrine manipulation in the management of this malignancy. During the 1960s progress in the understanding of the mechanism of hormone action, achieved through advances in molecular biology and the recognition of certain aspects of hormonal control in relation to the genome, introduced a new dimension for approaching endocrine manipulation of prostatic tumours. By the end of that decade a new scientific discipline devoted to prostate research had been born, which brought together investigators in the fields of molecular biology, biochemistry, endocrinology, immunology, urology and pathology to search for the cause and to explore methods for advancing the management of abnormal prostatic growth. Since then a wealth of scientific data has accumulated on the prostate in which endocrinology has manifested itself as the cardinal aspect to which most of the findings can be related.Table of Contents1 The development and morphology of the prostate.- 2 Histopathology of prostatic tumours.- 3 Hormonal environment of the normal prostate.- 4 Hormonal control and rationale for endocrine therapy of prostatic tumours.- 5 Biochemical and morphometric evaluation of prostatic epithelial and stromal cells.- 6 Metabolism of steroids in the prostate.- 7 Mechanism of action of androgens in the prostate.- 8 Analysis of steroid receptors in the prostate.- 9 Predictive role of steroid receptors in evaluating the response to endocrine therapy.- 10 The response of malignant prostate to endocrine treatment.- 11 The response of benign hypertrophied prostate to endocrine treatment.- 12 Experimental models in prostatic research.

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Table of ContentsI Embryology.- 1 The role of mesonephros in ovarian organogenesis.- II Ovarian Follicle Biodynamics.- 2 Hormonal control of ovarian follicular development.- 3 Recruitment selection and maturation of the dominant ovarian follicle in the menstrual cycle.- 4 Intraovarian regulation of maturation of granulosa cells.- 5 Influence of cyclic variations in gonadotrophin and steroid hormones on follicular growth in the human ovary.- 6 Hormonal control of Leydig cell function.- III Clinical Pathology.- 7 Evolution and function of non-ovulatory follicles.- 8 The menopausal ovary.- 9 The ovarian stroma after the menopause: activity and ageing.- 10 Ovary and pregnancy.- IV Clinical Physiopathology.- 11 Clinical investigation of luteal defect: a model for understanding the endocrine correlates of the menstrual cycle disorders.- 12 Gonadotrophin-resistant ovaries: a desensitization syndrome?.

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Book Synopsis

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Book Synopsis

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Book SynopsisThis book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.Table of Contents1. Basic Pharmacokinetic Principles.- 2. Antibiotic Pharmacodynamics.- 3. Physiological Manifestations of Critical Illness.- 4. Dosing in Obese Critically Ill Patients.- 5. Hypoalbuminemia and Altered Protein Binding.- 6. Antibacterial Pharmacokinetic/Pharmacodynamic Considerations in the Critically ill.- 7. Augmented Renal Clearance.- 8. Antibiotic Dosing During Extracorporeal Membrane Oxygenation.- 9. Therapeutic Drug Monitoring: More than Avoiding Toxicity.- 10. Generic and Optimised Antibacterial Dosing Strategies in the Critically Ill.- 11. Antifungal PK/PD in the Critically Ill.- 12. Antibiotic Dosing in Pediatric Critically Ill Patients.- 13. Antibiotic Stewardship in the Intensive Care Unit.

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