Diseases and disorders Books
Legare Street Press Idiocy and Its Treatment by the Physiological
Book Synopsis
£21.80
Legare Street Press Neurosyphilis Modern Systematic Diagnosis and
Book Synopsis
£23.70
Legare Street Press Brief Notes on the Outbreak of Plague in the
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£10.95
Austin Macauley Publishers Living with the Voices of Watchers and Hope
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£9.27
Springer-Verlag New York Inc. Antisense RNA Design Delivery and Analysis
Book SynopsisThis open access volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Antisense RNA Design, Delivery, and Analysis provides basic knowledge and a large collection of methods to facilitate the work Table of ContentsPart I: Overview 1. Introduction and History of the Chemistry of Nucleic Acids Therapeutics Michael J. Gait and Sudhir Agrawal 2. Antisense RNA Therapeutics: A Brief Overview Virginia Arechavala-Gomeza and Alejandro Garanto Part II: Design and Formulation of Antisense Technology 3. Design of Bifunctional Antisense Oligonucleotides for Exon Inclusion Haiyan Zhou 4. Design and Delivery of SINEUP: A New Modular Tool to Increase Protein Translation Michele Arnoldi, Giulia Zarantonello, Stefano Espinoza, Stefano Gustincich, Francesca Di Leva, and Marta Biagioli 5. How to Design U1 snRNA Molecules for Splicing Rescue Liliana Matos, Juliana I. Santos, Mª Francisca Coutinho, and Sandra Alves 6. Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles Paula Milán-Rois, Ciro Rodriguez-Diaz, Milagros Castellanos, and Álvaro Somoza 7. Determination of Optimum Ratio of Cationic Polymers and Small Interfering RNA with Agarose Gel Retardation Assay Omer Aydin, Dilek Kanarya, Ummugulsum Yilmaz, and Cansu Umran Tunc 8. Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen Valentina Palacio-Castañeda, Roland Brock, and Wouter P.R. Verdurmen Part III: In Vitro Model Systems 9. Development and Use of Cellular Systems to Assess and Correct Splicing Defects Nuria Suárez-Herrera, Tomasz Z. Tomkiewicz, Alejandro Garanto, and Rob W.J. Collin 10. Modeling Splicing Variants Amenable to Antisense Therapy by Use of CRISPR-Cas9-Based Gene Editing in HepG2 Cells Arístides López-Márquez, Ainhoa Martínez-Pizarro, Belén Pérez, Eva Richard, and Lourdes R. Desviat 11. In Vitro Models for the Evaluation of Antisense Oligonucleotides in Skin Jeroen Bremer and Peter C. van den Akker 12. In Vitro Delivery of PMOs in Myoblasts by Electroporation Remko Goossens and Annemieke Aartsma-Rus 13. Rapid Determination of MBNL1 Protein Levels by Quantitative Dot Blot for Evaluation of Antisense Oligonucleotides in Myotonic Dystrophy Myoblasts Nerea Moreno-Cervera, Irene Gonzalez-Martinez, Rubén Artero, and Estefanía Cerro-Herreros 14. Evaluation of Exon Skipping and Dystrophin Restoration in In Vitro Models of Duchenne Muscular Dystrophy Andrea López-Martínez, Patricia Soblechero-Martín, and Virginia Arechavala-Gomeza 15. Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro Pablo Herrero-Hernandez, Atze J. Bergsma, and W.W.M. Pim Pijnappel 16. Eye on a Dish Models to Evaluate Splicing Modulation Kwan-Leong Hau, Amelia Lane, Rosellina Guarascio, and Michael E. Cheetham 17. Establishment of In Vitro Brain Models for AON Delivery Elena Daoutsali and Ronald A.M. Buijsen Part IV: In Vivo Model Systems 18. Considerations for Generating Humanized Mouse Models to Test Efficacy of Antisense Oligonucleotides Irene Vázquez-Domínguez and Alejandro Garanto 19. Generation of Humanized Zebrafish Models for the In Vivo Assessment of Antisense Oligonucleotide-Based Splice Modulation Therapies Renske Schellens, Erik de Vrieze, Ralph Slijkerman, Hannie Kremer, and Erwin van Wijk 20. Use of Small Animal Models for Duchenne and Parameters to Assess Efficiency upon Antisense Treatment Ngoc Lu-Nguyen, Alberto Malerba, and Linda Popplewell 21. In Vivo Models for the Evaluation of Antisense Oligonucleotides in Skin Jeroen Bremer and Peter C. van den Akker 22. Delivery of Antisense Oligonucleotides to the Mouse Retina Alejandro Garanto 23. Delivery of Antisense Oligonucleotides to the Mouse Brain by Intracerebroventricular Injections Tom Metz, Elsa C. Kuijper, and Willeke M.C. van Roon-Mom 24. Intrathecal Delivery of Therapeutic Oligonucleotides for Potent Modulation of Gene Expression in the Central Nervous System Zachary Kennedy, James W. Gilbert, and Bruno M.D.C. Godinho Part V: Safety and Toxicology 25. Preclinical Safety Assessment of Therapeutic Oligonucleotides Patrik Andersson 26. Preclinical Evaluation of the Renal Toxicity of Oligonucleotide Therapeutics in Mice Lucía Echevarría and Aurelie Goyenvalle 27. Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution Kjetil Elvevold, Ingelin Kyrrestad, Karen Kristine Sørensen, and Bård Smedsrød Part VI: Intellectual Property 28. Patent Considerations When Embarking on New Antisense Drug Programs Laurence D.S. Gainey
£31.49
Cambridge University Press The Idea of Epilepsy
Book SynopsisEpilepsy has a fascinating history. To the medical historian Oswei Temkin it was ''the paradigm of the suffering of both body and soul in disease''. It is justifiably considered a window on brain function. And yet its story is more than simply a medical narrative, but one influenced also by scientific, societal and personal themes. Written for a medical and non-medical readership, this book describes the major developments in epilepsy between 18602020, a turbulent era in which science dominated as an explanatory model, medical theories and practices steered an erratic course, and when societal attitudes and approaches to epilepsy fluctuated dramatically. In the middle of this maelstrom was the person with epilepsy at the mercy of social attitudes and legislation, and at times harmed as well as helped by medicine and science. So entangled is the history that intriguingly, as an entity, epilepsy may now be thought not even to exist.Trade Review'… [the author guides] us through the various and different, truly anthropological perspectives on epilepsy by laying out before us readers his vast knowledge and deep wisdom related to the topic. All is so well organized, referenced and formulated in particularly clear and beautiful English.' Jürg Kesselring, Swiss Archives of Neurology, Psychiatry and Psychotherapy'… it presents as a beautiful study book, perfect to work with on a desk; however, it is much more than a study book, it is a book to be read and read again in a comfortable position.' Walter van Emde Boas, Brain Review… a marvellous achievement that is enough to ensure this exceptional work a prominent place in any epilepsy library.' Peter Wolf, Epilepsia Open'… this book is recommended reading for anyone willing to explore why they think about epilepsy the way they do – whether they may be involved professionally with epilepsy, live lives touched by this disease/disorder/condition or are simply interested in the interaction of science, medicine and society.' Markus Reuber, Seizure: European Journal of Epilepsy'… this book is a rich source of interesting aspects of the history of epilepsy in the past 160 years. It is recommended for physicians, in particular neurologists, and those non-medically trained persons interested in epilepsy and its history.' Peter J. Koehler, World NeurologyTable of ContentsPreface; Section 1. The voyage of the good ship epilepsy:; Introduction:; Prologue: a note on the concept of epilepsy; Section 2. 'A plague upon your epileptic visage'; 1. 1860–1914 the birth of modern epilepsy; 2. 1914–1945 epilepsy in the age of catastrophe; 3. 1945–1970 epilepsy and the new world order; 4. 1970–1995 epilepsy in a globalised world; 5. 1995–2020 the epilepsy floods are too recent; Section 3. Epilepsy: The paradigm of the suffering of both body and soul in disease; Epilogue: The separation of the wheat from the chaff; Appendix 1. The epilepsy balance sheet; Appendix 2. Obsolete or failed theories and treatments; Appendix 3. The international league against epilepsy; Glossary of scientific and medical terms in the field of epilepsy; Bibliography; Index of names; Index.
£64.99
McGraw-Hill Education / Medical Harrisons Principles of Internal Medicine Vol 1
Book Synopsis
£80.62
McGraw-Hill Education Anatomy Physiology Disease Foundations for the
Book SynopsisRoiger and Bullock's unique pedagogical and visual approach helps students make the important connections between systems and learn how the body functions normally in homeostasis, and how disruption of homeostasis leads to disease and disorder. With a straightforward, engaging writing style, the authors explain difficult concepts in the context of routine activities, making concepts easier to grasp. Measurable learning outcomes throughout the textbook, workbook, and digital learning and assessment program help direct students through the content so there are no surprises.Anatomy, Physiology, Disease requires no prior knowledge of chemistry or cell biology, and is designed for an anatomy and physiology course or an anatomy, physiology, and pathology course. It is neither too high nor too low and can be customized to accommodate the organization of individual courses.Table of Contents1 The Basics2 Levels of Organization of the Human Body3 The Integumentary System4 The Skeletal System5 The Muscular System6 The Nervous System7 The Nervous System—Senses8 The Endocrine System9 The Cardiovascular System—Blood10 The Cardiovascular System—Heart and Vessels11 The Lymphatic System12 The Respiratory System13 The Digestive System14 The Excretory/Urinary System15 The Male Reproductive System16 The Female Reproductive System
£47.69
McGraw-Hill Companies Loose Leaf for Human Genetics
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£140.40
John Wiley & Sons Lubkins Chronic Illness Impact and Intervention
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£109.00
Pen & Sword Books Ltd The History of the World in 100 Pandemics Plagues
Book SynopsisHighly topical - reveals the 100 (or so) most significant pandemics, plagues and epidemics in world history, from prehistory to Covid-19.
£21.25
Hay House Inc Body Belief
Book SynopsisImagine waking up feeling refreshed, strong, and vibrant, with your hormones in balance and your body nourished, stable, and supported on both the emotional and physical levels. For the millions who are grappling with rheumatoid arthritis, Hashimoto's thyroiditis, inflammatory bowel disease, type one diabetes, and numerous other autoimmune conditions, this vision seems so distant from the daily reality that it seems an impossibility. In spite of increasing knowledge and awareness, the causes and effects of autoimmune conditions are often misunderstood, and the connection between inner well-being and physical health is not fully explored.As an acupuncturist and herbalist with over 15 years of clinical experience, Aimee Raupp, M.S., L.Ac., has treated a variety of autoimmune conditions, as well as managed her own. Her Body Belief Plan bridges the gap between our internal and external healing to present a holistic and practical approach based on the core pillars of reconnecting to ourselvTrade Review"Aimee is a beacon of hope for all looking to improve their health and awaken their best life."— Deepak Chopra, M.D."Body Belief is must reading for every person who has ever felt sick and tired and doesn't know what's wrong. Rooted in compassion, rich with solid medical advice, and written by someone who has been there, Body Belief is a true treasure of life-changing information that will assist anyone in healing their body and their life."— Christiane Northrup, M.D., New York Times best-selling author of Women's Bodies, Women's Wisdom"Aimee Raupp is one of the most kind, generous, and talented healers. Her teachings have allowed me to transform the way I think about my body and my healing path. If you are longing to reawaken your health, Body Belief is the book you need and Aimee is the healer you want."— Gabrielle Bernstein, #1 New York Times best-selling author of The Universe Has Your Back"Aimee's teachings are filled with an immense amount of knowledge and research combined with real-life experience and a good dose of humor. In a masterful way, she equips her clients and followers with practical tools for achieving and maintaining optimal health and vitality despite the challenges of a modern lifestyle. She pours her wisdom and expertise and infuses her clients with the healing tools of self-love and self-acceptance."— Agapi Stassinopoulos, author of Wake Up to the Joy of You"Aimee Raupp understands that self-love can heal all parts of you—body and soul—and she can show you the path toward whole health in all its forms."— Rebekah Borucki, author of You Have 4 Minutes to Change Your Life"Aimee's message is a call to action for women of all ages to take control of their health through a path of self-love. The benefits transcend physical healing, aligning body, mind, and spirit to create optimal well-being and vitality."— Claudia Chan, author of This Is How We Rise
£15.19
John Wiley and Sons Ltd Cough
Book SynopsisCough is the most familiar symptom of respiratory disease, and a problem which general practitioners must deal with on a daily basis. This timely volume draws together a wealth of recent research into the mechanisms, pharmacology and therapies for cough, and places these in clinical context. The text incorporates guidelines on the most common causes of cough, discusses treatments and pitfalls in management, summarizes current research on physiology, pharmacology and treatment of cough, and gives practical advice on diagnosis and management issues for the clinician. Cough: Causes, Mechanisms and Therapy is the most comprehensive, up-to-date account of the subject. It will update clinical and basic medical scientists, and promote future research. Readers are encouraged to implement the clinical implications of the discussion into routine practice. This volume will appeal to all those involved in the treatment of respiratory disease, particularly those in hospital Table of ContentsContributors. Preface. Section 1: Introduction. 1 The clinical and pathophysiological challenge of cough. 2 Epidemiology of cough. 3 A brief overview of the mechanisms of cough. Section 2: Cough in the clinic. 4 Clinical assessment of cough. 5 Measurement and assessment of cough. 6 Cough sensitivity: the use of provocation tests. 7 Causes, assessment and measurement of cough in children. 8 The quality of life in coughers Section 3: Clinical conditions with cough. 9 Cough in lower airway infections. 10 Cough in gastro-oesophageal reflux. 11 Cough in postnasal drip, rhinitis and rhinosinusitis. 12 Cough and airway hyperresponsiveness. 13 Cough in chronic obstructive pulmonary disease (COPD). 14 Cough in suppurative airway diseases. 15 Cough in cancer patients. . Section 4: Pathophysiology. 16 Sensory pathways for the cough reflex. 17 Neurogenesis of cough. 18 Plasticity of vagal afferent fibres mediating cough. 19 Motor mechanisms and the mechanics of cough. 20 Mucus hypersecretion and mucus clearance in cough. 21 Animal models of cough. Section 5: Therapy. 22 Mechanisms of actions of centrally acting antitussives - electrophysiological and neurochemical analysis. 23 Pharmacology of peripherally acting antitussives. 24 Current and potential future antitussive therapies. 25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection. 26 Mucoactive agents for the treatment of cough. 27 Management of cough. Index
£128.66
John Wiley and Sons Ltd Syncope
Book SynopsisThe second edition of Syncope: Mechanisms and Management has been completely updated and revised and remains the most comprehensive textbook ever published on this common clinical entity. It provides up-to-date coverage of virtually every known cause of syncope, integrating knowledge of pathophysiology with practical guidelines for diagnosis and management. Incorporating clinical, investigative and experimental work conducted by leading authorities from all over the world, this book will serve as a practical resource for practicing cardiologists, electrophysiologists, neurologists, internists, pediatricians, and family physicians, as well as residents and fellows in these disciplines.Trade Review'The editors succeed in providing a comprehensive and up-to-date description of the broad scope of syncope, which makes this book a principal text in the field of syncope. The book is very well written and is an excellent addition to the library of any physician who seeks information on the causes, evaluation, and management of syncope.' Hamid Afshar (MD, Ochsner Clinic Foundation), DoodysTable of ContentsChapter 1: Syncope: An Overview of Evaluation and Management. Chapter 2: Neurocardiogenic Syncope. Chapter 3: Dysautonomic (Orthostatic) Syncope. Chapter 4: Bradyarrhythmias as a Cause of Syncope. Chapter 5: Tachyarrhythmias as a Cause of Syncope. Chapter 6: Use of Electrophysiologic Studies in Syncope: Practical Aspects of Diagnosis and Management. Chapter 7: Tilt Table Testing. Chapter 8: Use of Implantable Cardioverter Defibrillators in Patients With Syncope. Chapter 9: Neurologic Causes of Syncope. Chapter 10: Structural and Obstructive Causes of Cardiovascular Syncope. Chapter 11: Inherited Arrhythmic and Related Causes of Syncope. Chapter 12: Psychiatric Disorders in Patients With Syncope. Chapter 13: Postural Tachycardia, Orthostatic Intolerance and the Chronic Fatigue Syndrome. Chapter 14: Carotid Sinus Hypersensitivity. Chapter 15: Miscellaneous Causes of Syncope. Chapter 16: Syncope in the Child and Adolescent. Chapter 17: Syncope in the Athlete. Chapter 18: Syncope in the Elderly. Chapter 19: The Implantable Loop Recorder for Diagnosis of Unexplained Syncope. Chapter 20: Driving and Syncope. . Chapter 21: Syncope and the Law
£91.76
John Wiley & Sons Inc ABC of Palliative Care
Book SynopsisThis brand new edition pulls together the most up-to-date information on this complex, multidisciplinary area in a practical, user-friendly manner. It deals with the important social and psychological aspects for palliative care of people with incurable diseases including quality of life, communication and bereavement issues.Table of ContentsContributors vi Foreword viii 1 The principles of palliative care 1Balfour Mount, Geoffrey Hanks, Lorna McGoldrick 2 The principles of control of cancer pain 4Marie Fallon, Geoffrey Hanks, Nathan Cherny 3 Difficult pain 8Lesley Colvin, Karen Forbes, Marie Fallon 4 Breathlessness, cough, and other respiratory problems 13Carol Davis, Gillian Percy 5 Oral health in patients with advanced disease 17Jeremy Bagg, Andrew Davies 6 Anorexia, cachexia, nutrition, and fatigue 21Kenneth Fearon, Matthew Barber 7 Nausea and vomiting 25Kathryn Mannix 8 Constipation, diarrhoea, and intestinal obstruction 29Nigel Sykes, Carla Ripamonti, Eduardo Bruera, Debra Gordon 9 Depression, anxiety, and confusion 36Mari Lloyd-Williams 10 Emergencies 40Stephen Falk, Colette Reid 11 The last 48 hours 44James Adam 12 Palliative care for children 48Ann Goldman 13 Communication 52David Jeffrey 14 The carers 56Julia Addington-Hall, Amanda Ramirez 15 Chronic non-malignant disease 59Marie Fallon, Joanna Chambers, Francis Dunn, Raymond Voltz, Gian Borasio, Rob George, Roger Woodruff 16 Community palliative care 68Keri Thomas 17 Bereavement 74Marilyn Relf 18 Complementary therapies 78Michelle Kohn, Jane Maher Index 83
£39.56
John Wiley & Sons Inc ABC of Obesity
Book SynopsisObesity is a hugely expensive and increasing problem worldwide, leading to disability, reproductive problems, depression and accelerated metabolic and vascular diseases in a large proportion of men, women and children.Table of ContentsContributors vii Foreword ix 1 Obesity—time to wake up 1David Haslam, Naveed Sattar, Mike Lean 2 Assessment of obesity and its clinical implications 4Thang S Han, Naveed Sattar, Mike Lean 3 Management: Part I—Behaviour change, diet, and activity 8Alison Avenell, Naveed Sattar, Mike Lean 4 Management: Part II—Drugs 12Mike Lean, Nick Finer 5 Management: Part III—Surgery 16John G Kral 6 Strategies for preventing obesity 20Mike Lean, Jose Lara, James O Hill 7 Risk factors for diabetes and coronary heart disease 24Sarah H Wild, Christopher D Byrne 8 Obesity and vascular disease 27Debbie A Lawlor, Mike Lean, Naveed Sattar 9 Obesity and cancer 31Donald C McMillan, Naveed Sattar, Mike Lean, Colin S McArdle 10 Obesity and reproduction 34Jane E Ramsay, Ian Greer, Naveed Sattar 11 Childhood obesity 38John J Reilly, David Wilson 12 Obesity—can we turn the tide? 42Mike Lean, Laurence Gruer, George Alberti, Naveed Sattar Index 47
£30.56
John Wiley and Sons Ltd The Evaluation and Treatment of Syncope
Book SynopsisDesigned for the practitioner, this handbook provides an easy-to-read overview of how to evaluate and treat patients with a history of fainting. The 2nd Edition has been fully revised to contain all the latest information concerning diagnosis and treatment. It is based on the 2004 update of the ESC Guidelines on the Management of Syncope and offers up-to-date direction based on comprehensive analysis. All chapters share a consistent structure and are concise - only essential references are included. However, each chapter comes with suggestions for further reading and a comprehensive literature source is provided separately at the end of the book and divided into major interest areas. The ESC Education Series This book is part of the ESC Education Series. The series is designed to provide medical professionals with the latest information about the understanding, diagnosis and treatment of cardiovascular diseases. Where avTrade Review"This comprehensive tome is the most in depth presentation of the evaluation and treatment of patients with a history of fainting that I have come across.... You will learn a lot." (Cardiology News, June 2009)Table of ContentsSection one: Definition, pathophysiology, epidemiology. Chapter 1 Syncope: definition, classification, and multiple potential causes. Jean-Jacques Blanc, David G. Benditt. Chapter 2 Whatis syncope and whatis notsyncope: the importance of definitions. J. Gert van Dijk, Adam P. Fitzpatrick. Chapter 3 Pathophysiology and clinical presentation. Wouter Wieling, J. Gert van Dijk, Johannes J. van Lieshout, David G. Benditt. Chapter 4 Maintaining blood pressure while upright: physiology and potential for disturbances to cause syncope. Christopher J. Mathias. Chapter 5 Epidemiology and social costs of syncope. Rose Anne Kenny, Wishwa N. Kapoor. Section two: Syncope evaluation strategy. Chapter 6 Overview of recommended diagnostic strategies. Richard Sutton, Michele Brignole. Chapter 7 Initial evaluation of the syncope patient. Antonio Raviele, Paolo Alboni. Chapter 8 The role of the prepared questionnaire in initial evaluation of transient losses of consciousness. Anna Serletis, Robert S. Sheldon. Chapter 9 Who should be evaluated and treated in hospital, and who can be managed as an outpatient?. David G. Benditt. Chapter 10 Organizing management of syncope in the hospital and clinic (the syncope unit). Rose Anne Kenny, Michele Brignole. Chapter 11 Impact of syncope guidelines on clinical care. Michele Brignole. Section three: Specific diagnostic procedures. Chapter 12 Ambulatory electrocardiographic monitoring for evaluation of syncope. Adam P. Fitzpatrick, David G. Benditt. Chapter 13 Hemodynamic sensors: the future evaluation of syncope. David G. Benditt. Chapter 14 The basic autonomic assessment. Richard Sutton, David G. Benditt. Chapter 15 Electrophysiological testing. Fei Lü, Lennart Bergfeldt. Chapter 16 Miscellaneous diagnostic procedures: when are they indicated?. Lennart Bergfeldt, Piotr Kulakowski. Chapter 17 Neurologic diagnostic procedures in syncope. J. Gert van Dijk. Chapter 18 Contribution of psychiatric disorders to apparent syncope. George Theodorakis. Section four: Causes of syncope and syncope mimics, and treatment. Chapter 19 Who to treat. Michele Brignole, Rose Anne Kenny. Chapter 20 Specific causes of syncope: their evaluation and treatment strategies. Part 1 Neurally mediated reflex syncope. David G. Benditt, Jean-Jacques Blanc. Part 2 Orthostatic syncope. Angel Moya, Wouter Wieling. Part 3 Cardiac arrhythmias and conduction system disease as a primary cause of syncope. Angel Moya. Part 4 Structural cardiac and pulmonary causes of syncope. Jean-Jacques Blanc, Jan Janousek. Part 5 Cerebrovascular disorders as the primary cause of syncope. J. Gert van Dijk. Chapter 21 Syncope and other causes of transient loss of consciousness in children, teenagers, and adolescents. Wouter Wieling, Karin S. Ganzeboom, Jan Janousek. Chapter 22 Syncope in the older adult (including driving implications). Rose Anne Kenny, David G. Benditt. Chapter 23 Conditions that mimic syncope. J. Gert van Dijk. Section five: Selected references since 1990. Index
£81.65
John Wiley and Sons Ltd The Fainting Phenomenon
Book SynopsisFainting, the sudden and often unpredictable loss of consciousness, can be a frightening experience. While often benign, fainting can sometimes be the sign of serious illness. Recurrent fainting can significantly disrupt a person's life, and make them prone to injury and, on occasion, death. The Fainting Phenomenon, Second Edition is a valuable information resource for anyone whose life is affected by fainting. Written for the layperson, this book will help you: Understand the different reasons why people faint and their significance Seek proper medical attention and treatment Deal with related conditions such as Postural Tachycardia Syndrome and Orthostatic Hypertension This is an indispensable and reassuring guide for parents, families and care givers.Trade Review"This book would be a very useful introductory text for medical students and nurses to read … .A useful size and covers theory to an appropriate depth." (Cardiology News, October - November 2007) Review of edition 1: This book is packed with information in ‘layman’s terms’ – @we ordinary (non-medical) people’ can then start to understand different types of faints that are being experienced or witnessed. The book can get very technical in parts, but not overly, regarding the heart, brain and systems. The Fainting Phenomenon book by Blair Grub should be in every surgery in the UK, it is a must that every Dr should have to hand. This is also a very good book for anyone who faints, be they patient, parents or carers, it will set them off on the road to ask the right questions with medical people to obtain a diagnosis for faints to put people (old or young) who suffer from this phenomenon at ease. It is a must read and should be a best seller in every UK surgery and hospital!Table of Contents1 Introduction.. 2 The Fainting Phenomenon.. 3 The Normal Nervous System.. 4 The Normal Cardiovascular System.. 5 Orthostatic Intolerance and Orthostatic (postural) Hypotension.. 6 Neurocardiogenic Syncope.. 7 Postural Tachycardia Syndrome and Chronic Fatigue Syndrome.. 8 Other Possible Causes of Fainting.. 9 Fainting in Children and Adolescents and in Older People.. 10 Diagnosing the Underlying Causes of Fainting.. 11 Treating Fainting.. 12 Wrapping Up. Glossary of useful terms. Index.
£25.60
John Wiley and Sons Ltd Case Management of Longterm Conditions
Book SynopsisThe importance of appropriate and effective management of patient with long term chronic conditions cannot be underestimated.Case Management of Long-Term Conditions aims to provide all appropriate practitioners (including nurses, pharmacists, physiotherapists, andsocial care practitioners) who might be involved in delivery of proactive case management with a practical understanding of how their knowledge and skills can be utilised to improve outcomes for people with chronic long-term conditions. The text contains some broad reflections on care and service delivery based on reviews of evidence and views from clinicians in the use of these skills and competencies to deliver improved outcomes for clients.Table of ContentsIntroductionix 1 Background to the Implementation of Case Management Models for Chronic Long-Term Conditions within the National Health Service 1 Introduction 1 Primary care management of long-term conditions 2 How management approaches have been developed 3 Developing and delivering care 4 Future of care 5 The impact and cost of chronic disease 6 Identifying patients who require case management 7 National guidelines and evidence-based practice 8 Embedding evidence in practice 8 Making progress in the management of chronic conditions 9 Modernising care in the National Health Service 10 Developing case management and care delivery 10 Case management in the National Health Service 11 Promotion of self-management and self-care 13 Partnerships and expectations 13 Conclusion 15 References 15 2 Case Management Models: Nationally and Internationally 18 Introduction 18 The context for case management in the NHS 20 Impact of managed care models 21 International models of care reviewed 22 The Alaskan Medical Service 22 Kaiser Permanente (North California) 24 Group Health Cooperative (Seattle, Washington) 25 HealthPartners (Minnesota) 25 Touchpoint Health Plan (Wisconsin) 26 Anthem Blue Cross and Blue Shield (Connecticut) 26 UnitedHealth Europe Evercare 26 Amsterdam HealthCare System (the Netherlands) 27 Outcome intervention model (New Zealand) 28 National model of chronic disease prevention and control (Australia) 28 Guided Care (United States) 28 PACE (United States) 28 Veterans Affairs (Unites States) 29 Improving Chronic Illness Care (Seattle) 29 Expanded Chronic Care Model (Canada) 29 Pfizer (United States) 29 Green Ribbon Health: Medicare in health support (Florida) 30 What do these models provide? 30 Models in use in England 30 Care management in social care 32 Case management models in the NHS 32 Joint NHS and social care 36 Data for case management 38 Evaluation 38 Conclusion 40 References 41 3 Competencies for Managing Long-Term Conditions 43 Introduction 43 Development of the competency framework 44 What the competencies are expected to deliver 46 The competencies: what are they? 46 Domain A: advanced clinical nursing practice 47 Domain B: leading complex care co-ordination 49 Domain C: proactively manage complex long-term conditions 52 Domain D: managing cognitive impairment and mental well-being 52 Domain E: supporting self-care, self-management and enabling independence 55 Domain F: professional practice and leadership 57 Domain G: identifying high-risk people, promoting health and preventing ill health 58 Domain H: end-of-life care 59 Domain I: interagency and partnership working 60 What the competencies aim to do 61 Developing educational models to develop competencies 62 Conclusion 64 References 64 4 Outcomes for Patients – Managing Complex Care 66 Introduction 66 The areas of competence and deliverables for patients: Leading complex care co-ordination 66 Identifying high-risk patients, promoting health and preventing ill health 74 Interagency and partnership working 77 Conclusion 82 References 82 5 Outcomes for Patients – Advanced Nursing Practice 85 Introduction 85 Advanced clinical nursing practice 85 Proactively manage complex long-term conditions 91 Professional practice and leadership 94 Managing care at the end of life 97 Conclusion 101 References 102 6 Outcomes of Case Management for Social Care and Older People 105 Introduction 105 Policy drivers for the care of older people 105 Health and social care integration 108 Cost of care for older people 109 What do people expect in old age and how will these services be commissioned? 111 What does case management offer to older people? 112 Integrated models of care 114 Impact of case management on older people 114 Managing resources 118 Outcomes for older people 118 Conclusions 119 References 120 7 Outcomes for Patients – Cancer Care and End-of-Life Care 123 Introduction 123 Gold Standards Framework for Palliative Care 125 Integrated Cancer Care Programme 125 Preparing for the pilot programmes 127 Delivering the pilots 129 Programme outcomes 130 Case Management and ICCP 131 Case management competencies – what can/should patients expect? 132 The real need for competencies 137 Advanced care planning 139 Preferred place of care and delivering choice programmes 140 Conclusion 140 References 142 8 Leadership and Advancing Practice 144 Introduction 144 What is leadership? 144 What does leadership provide? 145 Leadership framework in the NHS 146 Skills in leadership 147 Political understanding and functioning 148 Setting targets and delivering outcomes 148 Empowerment and influencing 149 Levels of competence 150 Other leadership frameworks 150 What does good leadership do? 153 Impact on organisations 153 Leadership in case management 154 Leadership and change 155 Leadership is in every role 156 Advanced practice 157 Prescribing 158 Advanced practice in long-term conditions 159 Conclusions 160 References 161 9 Self-Care and Patient Outcomes 164 Introduction 164 What is self-care? 164 Self-care and practitioners 167 Systems for self-care 168 Expert Patient Programme 168 Effectiveness of self-care programmes 169 Promoting self-care: staff role 170 Self-care: models 171 Self-care: the evidence base 173 Using information and technology for self-care 175 How do we engage patients in self-care? 179 Conclusions 180 References 183 10 What Does This Mean for Patients? 185 Introduction 185 Government expectations 186 What do patients want from care? 186 Reported outcomes from management of long-term conditions 187 Modernisation to enable outcomes for users of services 188 Do patients really see improvement? 188 Understanding the patient experience, how we find out? 190 Public Service Agreement targets 192 Other assessments of user/patient experiences 192 Patient-centred care 195 Allowing patients to tell their tale 195 Outcomes of care and patient experience 195 Experience in case management 197 Partnerships with patients: impact on experience 199 Quality for patients 200 Impact of the provision of information on patients’ views and outcomes 201 Conclusions 201 References 203 Index 207
£38.66
Author Solutions Inc OVERCOMING A BAD GENE The story of the discovery and successful treatment of Phenylketonuria a genetic disease that causes mental retardation
£14.03
Taylor & Francis Inc Cancer Epigenetics
Book SynopsisDuring the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers DNA methylation and cancer Histone modifTable of ContentsThe Role of Epigenetics in Cancer. DNA Hypomethylation in Cancer. DNA Hypermethylation in Oncogenesis. Imprinting Alterations in Tumorigenesis. Proteins that Modulate DNA Methylation Aberrations in Cancer. The Role of DNA Methylation in Cancer Progression. Alterations in Histone Acetylation in Tumorigenesis. Histone Methylation and the Initiation of Cancer. The Role of Sirtuins in Aging and Tumorigenesis. Proteins that Alter Histone Modifications in Cancer. Dietary and Environmental Influences on Histone Modifications in Cancer. Noncoding RNAs in Cancer. Cancer-linked DNA Hyper- and Hypomethylation: Chromosome Positional Effects. Chromatin Remodeling and Cancer. Poly-ADP-ribosylation in Cancer. Polycomb Group Proteins in Tumorigenesis. Cancer and Aging: The Epigenetic Connection. DNA Methylation in Tumor Diagnosis. DNA Methylation Profiles as Prognostic Markers for Cancer. Diagnosing Cancer Using Histone Modification Analysis. Histone Modifications in Cancer Biology and Prognosis. Histone Deacetylase Inhibitors in Cancer Therapy. Methylation Changes in Neoplasia: Diagnostic and Therapeutic Implications. Clinical Trials and Approved Drugs for Epigenetic Cancer Therapy. Future Directions in Epigenetic Cancer Research.
£171.00
Taylor & Francis Inc Chronic Lymphocytic Leukemia
Book SynopsisWritten by authors from the world's most prominent cancer centers, Chronic Lymphocytic Leukemia supplies a comprehensive, up-to-date picture of CLL and how to better treat patients inflicted with the disease.New information on developments in the molecular pathogenesis of this disease impacts how physicians approach and treat patients with CLL. The various predisposing factors for the disease are addressed along with current and future treatment modalities and recommended standards of care.Key features include: introduction by Kanti Rai, MD who developed the Rai Classification and Staging system used in CLL diagnosis CLL in relationship to gene expression profiling and molecular abnormalities familial clustering and gene predisposition targeted therapy trials clinical patient management based upon stage and progression of disease Table of Contents1. Origin and Nature of the CLL Cell. 2. Gene Expression Profiling. 3. Molecular Pathogenesis. 4. CLL and the B Cell Receptor. 5. Epidemiology and Familial CLL. 6. Apoptosis Disregulation in CLL. 7. Differential Diagnosis, Staging, and Prognostic Factors. 8. Frontline Therapy. 9. Treatment of Relapsed Disease. 10. New Therapies. 11. Transplant in CLL. 12. Gene therapy, vaccines and immune modulation. 13. PLL. 14. CLL Specific Complications: Autoimmunity and Richter’s Syndrome. 15. Infections in CLL.
£161.50
Johns Hopkins University Press Life Histories of Genetic Disease
Book SynopsisWritten for historians, sociologists, and anthropologists of science and medicine, as well as bioethics scholars, physicians, geneticists, and families affected by genetic conditions, Life Histories of Genetic Disease is a profound exploration of the scientific culture surrounding malformation and mutation.Trade ReviewBy presenting a historical review of the critical scientific literature for these clinical examples, the narrative provides an excellent demonstration of the sequential, developmental process of scientific discovery and acceptance of disease mechanisms... Recomended. ChoiceTable of ContentsPreface Acknowledgments Introduction: Pursuing a Better Birth Chapter 1 Genetics Detectives Chapter 2 Chromosomal Cartography Chapter 3 The Genome's Morbid Anatomy Chapter 4 Seeing with Molecules Chapter 5 Institutionalized Disorders Chapter 6 Getting the Whole Picture Epilogue: The Genomic Gaze Notes Index
£35.00
Johns Hopkins University Press Riverblindness in Africa
Book SynopsisThe remarkable story of how a large public-private partnership worked to control and defeat riverblindnessa scourge which had devastated rural communities and impeded socioeconomic development throughout much of Sub-Saharan Africa for generations. Riverblindness (onchocerciasis)a pervasive neglected disease, transmitted by the blackfly, that causes horrific itching, disfigurement, and loss of visionis also known as lion's stare in reference to the fixed, lifeless glare of the eyes blinded by the disease. The disease has destroyed countless lives for generations, particularly in Africa. Its effects are so devastating that the areas where it is most common (large expanses of land around rivers where the fly breeds) end up abandoned as villages move farther and farther away to more arid environments in order to escape the fly-biting, and hence the disease. The disease devastates communities from multiple angles: a large portion of each stricken community's population is disabled, often Table of ContentsForeword, by James D. WolfensohnPrefaceAcknowledgmentsChapter 1. The ChallengeChapter 2. Launching and Scaling Up the Onchocerciasis Control Program Chapter 3. Expansion and RescueChapter 4. The Game Changer—IvermectinChapter 5. Getting Mectizan to Africa, Concluding the OCPChapter 6. A Closer Look at Socioeconomic DevelopmentChapter 7. Widening the Effort to All of AfricaChapter 8. Deepening and Widening the ObjectiveChapter 9. Learning from the Past, Looking to the FuturePeople InterviewedAcronyms and AbbreviationsNotesBibliographyIndex
£38.70
Xlibris The Homeopathic Treatment for Childrens Disease
Book Synopsis
£14.00
£9.68
John Wiley and Sons Ltd The Metabolic Syndrome
Book SynopsisThe Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syTrade Review"It's rare to find an academic book as engaging as this one. While clearly focused on a specific disease entity, the magnitude of the metabolic disease epidemic coupled with the comprehensive review of the topic this book delivers, should make it interesting reading to a diverse audience." (Doody's, 3 February 2012) "This excellent book must be considered the flagship text in the Wiley series encompassing obesity, diabetes and insulin resistance." (Practical Diabetes, 2011) "In all, the text provides a valuable summary of current knowledge, and it may even convince doubters of the existence of the metabolic syndrome! The information that is provided will be of considerable interest to both applied scientists and clinicians who study and treat the epidemics of physical inactivity and obesity that currently afflict so many countries." (Faculty of Physical Education & Health, 2011) Table of ContentsList of Contributors vii Foreword, Professor Sir George Alberti xi Preface xiii 1 The Epidemiology of the Metabolic Syndrome and its Association with Diabetes, Cardiovascular Disease and Other Conditions 1Sarah H. Wild and Christopher D. Byrne 2 Metabolic Syndrome and Ethnicity 19Therese Tillin and Nita G. Forouhi 3 Developmental Origins of Endothelial Dysfunction: a Key Step in Cardiometabolic Disease 45Christopher Torrens, Geraldine F. Clough and Mark A. Hanson 4 Developmental Origins of Insulin Resistance and Type 2 Diabetes 60Susan E. Ozanne and Kenneth Siddle 5 The Metabolic Syndrome in Childhood 81Ram Weiss and Sonia Caprio 6 Assessment of Insulin Sensitivity 88Julia Szendroedi, Esther Phielix and Michael Roden 7 Recent Progress in Identifying Genes Contributing to Type 2 Diabetes and Metabolic Syndrome 106Weijia Xie, Timothy M. Frayling and Michael N. Weedon 8 Endocrine Aspects of the Metabolic Syndrome 120Richard I.G. Holt and Peter H. Sönksen 9 Brain Insulin Resistance 139Katharine F. Hunt, Yee Seun Cheah and Stephanie A. Amiel 10 Cardiorespiratory Fitness and the Metabolic Syndrome 165Paul A. McAuley and Steven N. Blair 11 Metabolic Syndrome and Mental Illness 177Richard I.G. Holt and Robert C. Peveler 12 Atherothrombosis and the Metabolic Syndrome 194Kristina F. Standeven and Peter J. Grant 13 Inflammation and Metabolic Syndrome 210Sridevi Devaraj, David Siegel and Ishwarlal Jialal 14 Adipocytokine Dysregulation, Obesity and the Metabolic Syndrome 229Ulf Smith and Xiaolin Yang 15 Non-Alcoholic Fatty Liver Disease 245Mohamed H. Ahmed and Christopher D. Byrne 16 Polycystic Ovary Syndrome 278Naveed Sattar 17 Nutrition: Its Relevance in Development and Treatment of the Metabolic Syndrome 297Lisa Te Morenga and Jim Mann 18 Treatments for the Metabolic Syndrome 327Markolf Hanefeld, Ulrike Schatz and Frank Schaper 19 Metabolic/Bariatric Surgery Therapy for the Metabolic Syndrome 347Henry Buchwald Index 357
£80.96
Amberley Publishing Eyam
Book SynopsisA look in to the history behind the village of Eyam when the plague came killing the majority of the population.
£15.29
HarperCollins Publishers (Australia) Pty Ltd What Really Happened In Wuhan
Book SynopsisWalkley Award-winning journalist, Sharri Markson is the Investigations Editor at The Australian and host of prime-time show Sharri on Sky News Australia. The origins of Covid-19 are shrouded in mystery. Scientists and government officials insisted, for a year and a half, that the virus had a natural origin, ridiculing anyone who dared contradict this view. Tech giants swept the internet, censoring and silencing debate in the most extreme fashion. Yet it is undeniable that a secretive facility in Wuhan was immersed in genetically manipulating bat-coronaviruses in perilous experiments. And as soon as the news of an outbreak in Wuhan leaked, the Chinese military took control and gagged all laboratory insiders. Part-thriller, part-expose, What Really Happened in Wuhan is a ground-breaking investigation from leading journalist Sharri Markson into the origins of Covid-19, the cover-ups, the conspiracies and the classified research. It features never-before-seen primary documents exposin
£9.49
Xlibris Cancer Biology A Study of Cancer Pathogenesis
Book Synopsis
£21.85
Little, Brown Book Group How to Beat Panic Disorder One Step at a Time
Book SynopsisHow to Beat Panic Disorder One Step at a Time is specifically addressed to low-intensity patients and follows an evidence-based cognitive behavioural therapy (CBT) approach.This book is the perfect resource for helping you to beat panic attacks and panic disorder, either by yourself or in conjunction with the support of an IAPT service. Written in a friendly, engaging (and jargon-free!) style, the book encourages interactive reading through tables, illustrations and worksheets. Real-life case studies illustrate the use of each intervention and demonstrate how you can work through your condition. This book will help you to understand your panic cycle, and to face your fears through gradual exposure.Paul Farrand and Marie Chellingsworth have both worked at a national level in the area of CBT self-help research and training, with past involvement in organisations and programmes as diverse as the Department of Health, British Psychological Society, P
£8.54
Little, Brown Book Group How to Beat Worry and Generalised Anxiety
Book SynopsisHow to Beat Worry and Generalised Anxiety Disorder One Step at a Time is specifically addressed to low-intensity patients and follows an evidence-based cognitive behavioural therapy (CBT) approach. This book is the perfect resource for helping you to beat worry or Generalised Anxiety Disorder, either by yourself or in conjunction with the support of an IAPT service. The book is written in a friendly, engaging (and jargon-free!) style and encourages interactive reading through tables, illustrations and worksheets. Real-life case studies illustrate the use of each intervention and demonstrate how you can work through your anxiety. The book teaches you effective CBT techniques for managing your worry more effectively and releasing tension through Progressive Muscle Relaxation.
£10.44
Little, Brown Book Group How to Tell Anxiety to Sod Off
Book SynopsisAn accessible, comforting and practical book for anyone experiencing anxiety, from the author of The Recovery Letters and How to Tell Depression to Piss Off.Despite more and more people opening up about their mental health, anxiety is still taboo. We''re not supposed to be anxious; we''re supposed to be resilient and able to ''get on with it''. We are expected to excel while juggling a hectic, pressurised schedule at home and at work, despite the lines between the two being more blurred than ever.This book dispels that taboo. It is for anyone who has experienced general anxiety disorder, trauma-related anxiety, clinical anxiety and those with ''low-level'' anxieties.At once empathetic and entertaining, How to Tell Anxiety to Sod Off offers 40 ways to get to a better place with anxiety. They are born out of the author''s personal experience of managing his own anxiety and his many years of working as a counselor helping people with Trade ReviewJames takes a super-serious message and delivers it with a twinkle in his eye. You end up accidentally learning loads of stuff -- Andy Cope, bestselling author of The Art of Being BrilliantThere are two notable elements to this book. Firstly, the entertaining and self-deprecating (and funny) but personal style of writing means that it is easy to connect with the author, and not see him as a preachy guru from on high. Secondly, the book is packed with solid advice for how we can relate to our anxiety in way that still allows us to live our best life. Highly recommended -- Nic Hooper, senior lecturer in psychology and author of The Unbreakable StudentA book to play anxiety bingo with and one that will help you realise you are not alone in experiencing absurd mental terrors that feel horribly real. James makes it very funny too, because the ludicrousness of where our anxiety imagination can take us can be as funny on the page as it is horrifying when it is playing out in our mind. You will laugh and come away from this tooled up for the next battle in your mind's darker corners -- Robin Ince, comedianJames has written a wonderfully light-hearted, down-to-earth and practical book that has the potential to help many people and in many ways. How to Tell Anxiety to Sod Off is a joy to read, and James' jargon-free and authentic style will appeal to all those who need help with anxiety -- Richard Nicholls, writer and psychotherapistOne of the best ways to tell anxiety to sod off is to laugh. Which is where James Withey's book is different to many other books about how to stop worrying. It's funny! I mean, really side-splitting, roar-out-loud funny. Crammed with good advice as well as laughs, I now have it by my bedside -- Rachel Kelly, mental health advocate and Sunday Times bestselling author of Black RainbowIt's a rare gift to be able to engage with the serious subject of anxiety and be entertaining and funny at the same time. However, James Withey nails both in his new book. Any reader who applies his straight-talking, accessible advice to their anxiety will most certainly have it sodding off in no time -- Dr Aaron Balick, psychotherapist and authorAs a person with anxiety who loves swearing, this book is sodding helpful -- Julie Cohen, bestselling authorA humorous, accessible and genuinely helpful pick 'n' mix of anecdotes and tips to help put anxiety back in its box -- Lucy Nichol, author and mental health campaigner
£12.59
John Murray Press In Pursuit of Memory
Book SynopsisTrade ReviewJoseph Jebelli's wonderfully clear, vividly readable and comprehensive survey of the search for a cure . . . The world is closing in on Alzheimer's. There is nowhere left for it to hide * THE TIMES *A fascinating quest at the frontiers of neuro-degeneration... and a moving, sober and forensic study of the past, present and future of Alzheimer's from the point of view of a neurologist who has lived with the disease, at home and in the lab, from a very young age. The story Jebelli tells illustrates the tantalising mystery of Alzheimer's: it's both highly visible yet agonizingly elusive...a timely analysis [that] might give comfort. -- ROBERT McCRUM * OBSERVER *A personal story and smart scientific thinking reveal the history and humanity behind an epidemic that affects 44 million people worldwide * NEW SCIENTIST *A riveting debut... the very human story of the disease that is now an epidemic * BOOKSELLER, SCIENCE BOOK OF THE MONTH *In Pursuit of Memory is a remarkable combination of fine writing, personal honesty and deep scientific insight - about a devastating and baffling disease that is becoming all too common. Jebelli weighs up all the evidence and all the theories about Alzheimer's and even allows us a glimpse of optimism about a cure * MATT RIDLEY *An accessible, diligently researched and well-travelled overview of the disease that is more deadly than cancer. Jebelli poignantly weaves the current science with the tragic stories of affected families, not least his own * SUNDAY TIMES *The definitive portrait of Alzheimer's disease - an illness that is rapidly becoming the defining plague of the 21st century * Big Issue *On the surface it's about Alzheimer's disease but more than that it demonstrates how challenging it is to understand the brain -- Suzanne O'Sullivan * Observer, BOOKS OF THE YEAR *An elegant and precise writer, Jebelli follows every lead for a cure with the panache of a detective novelist, giving readers much to hope for despite the devastation Alzheimer's has left in its wake. Based on his meticulous and wide-ranging research, he makes a convincing argument that Alzheimer's will be defeated in the decades to come. Jebelli analyzes every facet of Alzheimer's with personal empathy and scientific rigor, a combination that makes for enthralling reading. * Kirkus, starred review *
£11.69
Scribner Book Company The Gene An Intimate History
Book Synopsis
£28.00
Springer Viral Infections of Humans
Book SynopsisI. Concepts & Methods.- 1.Concepts in Viral Disease Epidemiology & Control.- 2.Virologic Detection & Characterization.- 3.Immunologic Detection & Characterization.- 4.Surveillance & Epidemiologic Investigation.- 5.Viral Dynamics & Mathematical Models.- II. Viruses Causing Acute Syndromes.- 6.Adenoviruses.- 7.Alphaviruses:Equine Encephalitis & Others.- 8.Arenaviruses:Lassa Fever, Lymphocytic Choriomeningitis & Others.- 9.Bunyaviruses:Hantavirus & Others.- 10.Coronaviruses: Severe Acute Respiratory Syndrome & Others.- 11.Enteroviruses &Parechoviruses: Echoviruses, Coxsackieviruses, & Others.- 12.Enteroviruses:Enterovirus 71.- 13.Enteroviruses:Polio.- 14.Filoviruses: Marburg & Ebola.- 15.Flaviviruses: Dengue.- 16.Flaviviruses: Yellow Fever, Japanese B, West Nile & Others.- 17.Hepatitis A Virus.- 18.Hepatitis E Virus.- 19.Influenza Viruses.- 20.Noroviruses, Sapoviruses, & Astroviruses.- 21.Orthopoxviruses: Variola, Vaccinia, Cowpox & Monkeypox.- 22.Paramyxoviruses: Henipaviruses.- 23.Paramyxoviruses: Measles.- 24.Paramyxoviruses: Mumps.- 25.Paramyxoviruses Parainfluenza Virus.- 26.Paramyxoviruses: Respiratory Syncytial Virus & Metapneumovirus.- 27. Parvoviruses.- 28.Rhabdovirus: Rabies.- 29. Rhinoviruses: Colds.- 30. Rotaviruses.- 31. Rubella Virus.-III. Viruses Causing Acute & Chronic Syndromes &/or Malignancy.- 32. Hepatitis viruses: Hepatitis B & Hepatitis D.- 33.Hepatitis viruses: Hepatitis C.- 34. Hepatitis viruses: Hepatocellular Carcinoma.- 35. Human Herpesviruses: Cytomegalovirus.- 36.Human Herpesviruses: Herpes Simplex Types 1 & 2.- 37.Human Herpesvirus: Human Herpesvirus 6.- 38.Human Herpesviruses: Infectious Mononucleosis & Other Non-Malignant Diseases.- 39.Human Herpesviruses: Kaposi Sarcoma & Other Malignancies.- 40.Human Herpesviruses: Malignant Lymphoma.- 41.Human Herpesviruses: Nasopharyngeal Carcinoma & Other EpithelialTumors.- 42.Human Herpesviruses: Varicella & Zoster.- 43.Human Immunodeficiency Viruses Types 1 & 2.- 44.Human Papillomaviruses: Cervical Cancer & Warts.- 45.Human T Cell Leukemia Viruses Types 1 & 2.- 46.Polyomaviruses: Progressive Multifocal Leukoencephalopathy & Other Diseases.- IV Other Transmissible Agents.- 47.Prions & Transmissible Spongiform Encephalopathy.Table of ContentsI. Concepts & Methods.- 1.Concepts in Viral Disease Epidemiology & Control.- 2.Virologic Detection & Characterization.- 3.Immunologic Detection & Characterization.- 4.Surveillance & Epidemiologic Investigation.- 5.Viral Dynamics & Mathematical Models.- II. Viruses Causing Acute Syndromes.- 6.Adenoviruses.- 7.Alphaviruses:Equine Encephalitis & Others.- 8.Arenaviruses:Lassa Fever, Lymphocytic Choriomeningitis & Others.- 9.Bunyaviruses: Hantavirus & Others.- 10.Coronaviruses: Severe Acute Respiratory Syndrome & Others.- 11.Enteroviruses & Parechoviruses: Echoviruses, Coxsackieviruses, & Others.- 12.Enteroviruses:Enterovirus 71.- 13.Enteroviruses:Polio.- 14.Filoviruses: Marburg & Ebola.- 15.Flaviviruses: Dengue.- 16.Flaviviruses: Yellow Fever, Japanese B, West Nile & Others.- 17.Hepatitis A Virus.- 18.Hepatitis E Virus.- 19.Influenza Viruses.- 20.Noroviruses, Sapoviruses, & Astroviruses.- 21.Orthopoxviruses: Variola, Vaccinia, Cowpox & Monkeypox.- 22.Paramyxoviruses: Henipaviruses.- 23.Paramyxoviruses: Measles.- 24.Paramyxoviruses: Mumps.- 25.Paramyxoviruses Parainfluenza Virus.- 26.Paramyxoviruses: Respiratory Syncytial Virus & Metapneumovirus.- 27. Parvoviruses.- 28.Rhabdovirus: Rabies.- 29. Rhinoviruses: Colds.- 30. Rotaviruses.- 31. Rubella Virus.- III. Viruses Causing Acute & Chronic Syndromes &/or Malignancy.- 32. Hepatitis viruses: Hepatitis B & Hepatitis D.- 33.Hepatitis viruses: Hepatitis C.- 34. Hepatitis viruses: Hepatocellular Carcinoma.- 35. Human Herpesviruses: Cytomegalovirus.- 36.Human Herpesviruses: Herpes Simplex Types 1 & 2.- 37.Human Herpesvirus: Human Herpesvirus 6.- 38.Human Herpesviruses: Infectious Mononucleosis & Other Non-Malignant Diseases.- 39.Human Herpesviruses: Kaposi Sarcoma & Other Malignancies.- 40.Human Herpesviruses: Malignant Lymphoma.- 41.Human Herpesviruses: Nasopharyngeal Carcinoma & Other Epithelial Tumors.- 42.Human Herpesviruses: Varicella & Zoster.- 43.Human Immunodeficiency Viruses Types 1 & 2.- 44.Human Papillomaviruses: Cervical Cancer & Warts.- 45.Human T Cell Leukemia Viruses Types 1 & 2.- 46.Polyomaviruses: Progressive Multifocal Leukoencephalopathy & Other Diseases.- IV Other Transmissible Agents.- 47.Prions & Transmissible Spongiform Encephalopathy.
£269.99
Springer-Verlag New York Inc. An Introduction to Mathematical Epidemiology
Book SynopsisThe book is a comprehensive, self-contained introduction to the mathematical modeling and analysis of infectious diseases. It includes model building, fitting to data, local and global analysis techniques. Various types of deterministic dynamical models are considered: ordinary differential equation models, delay-differential equation models, difference equation models, age-structured PDE models and diffusion models. It includes various techniques for the computation of the basic reproduction number as well as approaches to the epidemiological interpretation of the reproduction number. MATLAB code is included to facilitate the data fitting and the simulation with age-structured models.Trade Review“The current book is an introductory text that starts at the level of the neophyte and gradually brings the student to the level of current research. … The target readers include advanced undergraduate and graduate students in mathematics as well as graduate students in other fields. … This is an appealing book, well-written and thoughtfully organized.” (William J. Satzer, MAA reviews, maa.org, January, 2016)“This book does not limit itself by any means to be just an introductory level textbook, aiming actually to be a comprehensive, self-contained reference text for mathematical epidemiologists. … The presentation is example-based, well thought out and very carefully organized. … The book has the clarity of a textbook while having the depth of a monograph, the author always being successful in conveying the content of a topic regardless of its difficulty.” (Paul Georgescu, zbMATH 1333.92006, 2016)Table of ContentsIntroduction.- Introduction to Epidemic Modeling.- The SIR Model with Demography: General Properties of Planar Systems.- Vector-Borne Diseases.- Techniques for Computing R0.- Fitting Models to Data.- Analysis of Complex ODE Epidemic Models: Global Stability.- Multi-strain Disease Dynamics.- Control Strategies.- Ecological Context of Epidemiology.- Zoonotic Disease, Avian Influenza and Non-autonomous Models.- Age-structured Epidemic Models.- Class-age Structured Epidemic Models.- Immuno-Epidemiological Modeling.- Spatial Heterogeneity in Epidemiological Models.- Discrete Epidemic Models.
£62.99
iUniverse Multiple Sclerosis from Both Sides of the Desk
Book Synopsis
£12.71
Humana Press Inc. Neisseria meningitidis
Book SynopsisNeisseria meningitidis is a major causative agent, worldwide, of potentially life-threatening meningitis and septicaemia, which carry with them a high mortality rate and permanent physical and neurological issues for survivors. Neisseria meningitidis: Advanced Methods and Protocols offers a collection of methods and protocols that reflect the development and refinement of several new technologies applied to the meningococcus as presented by expert researchers. Several of the chapters in this book describe methods that rely on the collection of complete sets of biological data, for example, using the genome to generate transcriptomes, proteomes, and metabolomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Table of Contents1. Neisseria meningitidis: Biology, Microbiology, and Epidemiology Nadine G. Rouphael and David S. Stephens 2. Classification and Pathogenesis of Meningococcal Infections Petter Brandtzaeg and Marcel van Deuren 3. Detection of Neisseria meningitidis in Cerebrospinal Fluid Using a Multiplex PCR and the Luminex Detection Technology Jens Kjølseth Møller 4. Generating Knock-Out and Complementation Strains of Neisseria meningitides Vincent van Dam and Martine P. Bos 5. Identification and Functional Characterization of sRNAs in Neisseria meningitides Yvonne Pannekoek and Arie van der Ende 6. Expression, Purification, and Crystallization of Neisserial Outer Membrane Proteins Muhammad Saleem, Jeremy Moore, and Jeremy P. Derrick 7. Genome-Scale Metabolic Models: Reconstruction and Analysis Gino J.E. Baart and Dirk E. Martens 8. TMT Labeling for the Quantitative Analysis of Adaptive Responses in the Meningococcal Proteome Karsten Kuhn, Christian Baumann, Jan Tommassen, and Thorsten Prinz 9. Meningococcal Ligands and Molecular Targets of the Host Darryl J. Hill and Mumtaz Virji 10. In Vivo Imaging of Meningococcal Disease Dynamics Hong Sjölinder and Ann-Beth Jonsson 11. Methods for Studying Neisseria meningitidis Biofilms Michael A. Apicella, Jianqiang Shao, and R. Brock Neil 12. A Laminar-Flow Chamber Assay for Measuring Bacterial Adhesion Under Shear Stress Magali Soyer and Guillaume Duménil 13. Techniques to Measure Pilus Retraction Forces Nicolas Biais, Dustin Higashi, Magdalene So, and Benoit Ladoux 14. Human Dendritic Cell Culture and Bacterial Infection Hannah E. Jones, Nigel Klein, and Garth L.J. Dixon 15. Hydrogen-Deuterium Exchange Coupled to Mass Spectrometry (H/DX-MS) to Investigate Ligand-Receptor Interactions Jessmi M.L. Ling, Leslie Silva, David C. Schriemer, and Anthony B. Schryvers 16. Visualizing PAMP-PRR Interactions Using Nanoscale Imaging Kathy Triantafilou and Martha Triantafilou 17. Transcriptome Analyses in the Interaction of Neisseria meningitidis with Mammalian Host Cells Biju Joseph, Matthias Frosch, Christoph Schoen, and Alexandra Schubert-Unkmeir 18. The Use of the Pan-Neisseria Microarray and Experimental Design for Transcriptomics Studies of Neisseria Nigel J. Saunders and John K. Davies 19. Analysis of Parameters Associated with Prevention of Cellular Apoptosis by Pathogenic Neisseriae and Purified Porins Paola Massari and Lee M. Wetzler 20. Analysis of the Immune Response to Neisseria meningitidis Using a Proteomics Approach Jeannette N. Williams, Myron Christodoulides, and John E. Heckels 21. Antigen Identification Starting from the Genome: A "Reverse Vaccinology" Approach Applied to MenB Emmanuelle Palumbo, Luigi Fiaschi, Brunella Brunelli, Sara Marchi, Silvana Savino, and Mariagrazia Pizza 22. A DNA Vaccine Strategy for Effective Antibody Induction to Pathogen-Derived Antigens Jason Rice and Myron Christodoulides
£114.75
University of Nebraska Press Diabetes in Native Chicago
Book SynopsisMargaret Pollak explores experiences, understandings, and care of diabetes in a Native urban community in Chicago made up of individuals representing more than one hundred tribes from across the United States and Canada.Trade Review"Pollak's book is an important and valuable addition to medical historiography. It will be beneficial to a wide audience in the field of history as well as for medical professionals and clinicians. The use of oral history is important in a study like this to give voice to those who have been previously hidden from history. The book is extremely well written and has an excellent flow. It was an enjoyable read and covers a fascinating scope."—Lauren Young, H-Sci-Med-Tech"Drawing on extensive ethnographic interviews, observations, informal conversations, surveys, and field literature, Pollak offers a rich exploration of indigenous Chicagoans' experiences, care, and cultural understandings, noting how diabetes shapes beliefs and practices among those living with the disease and care providers. The study concludes by broadly examining historical and contemporary factors that led to the ongoing epidemic, and subsequently formulated indigenous lay perceptions of illness and health, and how that knowledge may be incorporated into the health-care system to strengthen outcomes, making this book an important contribution."—G. R. Campbell, Choice“The interdisciplinary approach to this subject makes an important contribution not only to medical anthropology and Native American studies but also to public health, medical humanities, American studies, and cultural studies. Pollak deftly and simply lays out the discursive turns of biomedical explanations about diabetes within historical context and also demonstrates the structural injustices that complicate biomedical interventions.”—Sandra L. Garner, author of To Come to a Better Understanding: Medicine Men and Clergy Meetings on the Rosebud Reservation, 1973–1978Table of ContentsList of Tables Acknowledgments Introduction 1. The Building of Chicago’s Contemporary Indigenous American Population 2. Native Chicago 3. Diabetes among Indigenous Americans 4. Diabetes in Native Chicago 5. Local Understandings and Explanations of Diabetes 6. Care in the Context of Chronicity Conclusion Appendix 1: Interview Participants Appendix 2: Sample Questions Appendix 3: Research Approval Notes Bibliography Index
£40.50
Atria Books Influenza The HundredYear Hunt to Cure the 1918
Book Synopsis
£14.45
Cornell University Press Walking Corpses Leprosy in Byzantium and the
Book SynopsisTrade ReviewA very readable introduction to a fascinating subject and a valuable example of the importance of studying the Byzantine origins of medieval institutions. * Church History *This is a compact, accessible study, which delivers on its promise to bring the insights provided by studies of late antique Greek leprosy to bear on medieval Latin ones. * History of Religions *A welcome resource for the teaching of medieval leprosy, a fraught and fascinating topic in undergraduate classrooms. Walking Corpses both expands the field of study and shows directions in which this necessary endeavor can be continued. * Comitatus *
£21.59
Skyhorse Publishing Recovery from Lyme Disease: The Integrative
Book SynopsisFrom the foreword by world-leading Lyme expert Joseph J. Burrascano, Jr., MD:A detailed and thoughtful road map is sorely needed. And it is in this context that I am so pleased that we have this book by Dr. Kinderlehrer. I wish I’d had a book like this back in the day to guide me! It covers just about everything—the infections, diagnostic tests, treatments, and yes, the all-important terrain. It gives the reader an in-depth, but easily understandable, guide through the many subtleties of tick-borne illnesses. I am impressed with the knowledge presented and grateful for this information, which has helped so many people recover from chronic illness.To anyone touched by tick-borne diseases, be they a patient, a caregiver, loved one, or health practitioner, this book is a must-read. It will serve as a continuing reference as it gets read and reread to assimilate all it has to offer. I congratulate Dr. Kinderlehrer and thank him for this most impressive work.The ultimate guide to recognizing, coping with, and overcoming chronic infection.Lyme Disease is a substantial problem. While the CDC reported 427,000 new cases in 2017 based on surveillance criteria, actual numbers based on clinical diagnosis put that number at over one million. It is now well accepted that 10 to 20 percent of these cases go on to become a chronic illness, and these numbers don't even include those people who became chronically ill without ever witnessing a tick attachment or a bulls-eye rash. In other words, hundreds of thousands of people develop a chronic illness every year.This is why Dr. Dan Kinderlehrer’s book is so important and timely and has the potential to help millions who are victims of this epidemic. His integrative approach offers the most up-to-date and comprehensive plan available for treating and beating this disease. It will discuss brand new treatments such as disulfiram, which is being hailed as a major breakthrough, as well as the use of cannabis to treat pain and anxiety, among other developments in the field. With the staggering growth we are seeing in numbers of people afflicted, this book becomes more important every day.Kinderhlehrer is in a unique position to write this book. After completing a residency in Internal Medicine in 1979, he opened one of the first practices in the US in what was then called Holistic Medicine. After becoming an expert in nutrition and environmental illness, he became ill himself with Lyme disease complex. His long road to recovery has given him insights into what patients are going through; his background in internal medicine trained him to understand the complexities of his multi-systemic illness; his knowledge of environmental illness has enabled him to evaluate immune dysregulation; and his study of energetic medicine, spiritual alignment, and healing from trauma has yielded insights into how to help patients shift their belief systems to being well.Recovery from Lyme Disease is by far the most thorough book available on Lyme Disease Complex. It will provide patients with information that will guide them on their healing journeys, as well as supplying doctors with instruction on appropriate diagnosis and treatment approaches.
£17.99
Skyhorse Publishing Recovery from Lyme Disease: The Integrative
Book SynopsisFrom the foreword by world-leading Lyme expert Joseph J. Burrascano, Jr., MD:A detailed and thoughtful road map is sorely needed. And it is in this context that I am so pleased that we have this book by Dr. Kinderlehrer. I wish I’d had a book like this back in the day to guide me! It covers just about everything—the infections, diagnostic tests, treatments, and yes, the all-important terrain. It gives the reader an in-depth, but easily understandable, guide through the many subtleties of tick-borne illnesses. I am impressed with the knowledge presented and grateful for this information, which has helped so many people recover from chronic illness.To anyone touched by tick-borne diseases, be they a patient, a caregiver, loved one, or health practitioner, this book is a must-read. It will serve as a continuing reference as it gets read and reread to assimilate all it has to offer. I congratulate Dr. Kinderlehrer and thank him for this most impressive work.By far the most thorough work available on Lyme Disease Complex, this book provides patients with information that will guide them on their healing journeys, as well as supplying doctors with instruction on appropriate diagnosis and treatment approaches.Lyme Disease is a major problem. While the CDC reported 427,000 new cases in 2017 based on surveillance criteria, actual numbers based on clinical diagnosis put that number at well over one million. It is now well accepted that 10 to 20 percent of these cases go on to become a chronic illness, and these numbers don’t even include those people who became chronically ill without ever witnessing a tick attachment or a bull’s-eye rash. In other words, hundreds of thousands of people develop a chronic illness every year with Lyme disease.This is why Dr. Kinderlehrer’s book is so critical and timely and has the potential to help millions who are victims of this epidemic. His integrative approach offers the most up-to-date and comprehensive plan available for treating and beating this disease. It discusses brand new treatments such as disulfiram, which is being hailed as a major breakthrough, as well as the use of cannabis to treat pain, anxiety, and inflammation among other developments in the field. With the staggering growth we are seeing in numbers of people afflicted, this book becomes more important every day.Trade Review“Many of the illnesses that have proven difficult to treat effectively—such as lupus, multiple sclerosis, Alzheimer’s disease, and Lou Gehrig’s disease—are diseases without known cause. In Recovery from Lyme: The Integrative Medicine Guide to Diagnosing and Treating Tick-Borne Illness, Dr. Daniel Kinderlehrer shows that tick-borne illnesses such as Lyme disease (Borreliosis), Bartonellosis, and Babesiosis, may be associated with a surprisingly wide range of symptoms and diseases, from multiple sclerosis to PANS (pediatric acute onset neuropsychiatric syndrome) to depression to rheumatoid arthritis and many more. Dr. Kinderlehrer describes how to recognize, evaluate, and treat these tick-borne illnesses, and the important lessons he offers in this book could alleviate suffering for the many in whom these diseases often go unrecognized. I recommend this book highly for anyone dealing with the diverse symptoms that may be related to tick-borne illnesses.”—Dale Bredesen, MD, professor and New York Times bestselling author of The End of Alzheimer’s "Dr. Kinderlehrer’s approach to treating Lyme is a model of how medicine should be practiced. He combines meticulous, compassionate attention to all aspects of a patient’s health together with both rigorous attention to evidence informed by extensive knowledge of published and unpublished studies as well as an openness to consider novel therapies when more traditional therapies prove ineffective."—Peter Van Etten, former President/CEO of Stanford Medical Center “Dr. Daniel Kinderlehrer has written a comprehensive and readable book for both physicians and consumers that will provide them with an excellent understanding of what Lyme disease is and how to treat it. Recovery from Lyme is filled with patient stories that will enable the public to resonate to this information and assimilate it more easily. Having struggled with his own Lyme disease and finding his own path to healing, who better to provide this guide?”—Neil Nathan, MD, author of Toxic: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness “In this comprehensive and informative book, Dr. Kinderlehrer brings to the table his many years of research and experience with chronic Lyme disease patients. He shares in a succinct, yet easy to understand format, the multifaceted challenges of treating one of today's most complex and debilitating diseases. Perhaps even more importantly, he provides solid, research-based solutions that have been helpful for enabling many thousands of Lyme disease patients to recover their lives. These include natural as well as pharmaceutical remedies, as well as therapies that restore every organ and system of the body. Dr. Kinderlehrer's approach goes beyond removing infections, and addresses the healing of the whole person, which is key to recovering from this disease. Readers will find a wealth of powerful insights and keys in this book that will enable them and/or their patients to overcome and get their lives back.”—Connie Strasheim, health consultant, medical researcher, and co/author of 12+ books on Lyme disease, cancer, detoxification, nutrition, sleep, and spiritual/emotional healing“If you are a health practitioner unfamiliar with Lyme disease and other tick-borne infections, or if you have been treating these conditions for years (or if you are anywhere in between), Daniel Kinderlehrer’s Recovery from Lyme Disease will likely become your most valued guide for how to best diagnose and treat these patients. And if you are not a medical person but wish or need to learn how a master physician would evaluate and treat you, this is the book for you. It is written in language that a layperson will easily understand and yet has the depth that any health professional will appreciate. What is so unique and immensely skillful of Dr. Kinderlehrer’s work is that he is able to broaden one’s perspective while seamlessly holding a magnifying glass over critical details. It is so rare in my experience to read a book that is both academic and yet is equally clinical. And it is additionally rare and even precious that a doctor can be both authoritative and humble. It is most evident that Dr. Kinderlehrer has dedicated himself to learning everything he has been able to learn to best understand and help his patients. And now, as the teacher he is, he has given us a true gift to become more skillful with Lyme patients and truly better physicians. Bravo, Dr. Kinderlehrer!”—Ralph Golan, MD, author of Optimal Wellness: Where Mainstream and Alternative Medicine Meet “Dr. Kinderlehrer's book is the most authoritative compendium to date on the numerous facets of an illness that deserves so much more than a simple four-letter label. For the masses suffering with this complex, multi-factorial illness that does not exist in the medical mainstream, Dr. Kinderlehrer's book will come as an inspiration for patients and a guiding light for physicians. He shares the culmination of nearly 50 years' clinical practice in this gem of a book that will enrich generations to come. There is no praise high enough for his work both with patients and teaching other physicians. Thanks to Dr. Kinderlehrer for teaching me the subtleties and nuances of treating this labyrinthine disease.”—Julie M. Barter, ND “In Recovery from Lyme: The Integrative Guide to the Diagnosis and Treatment of Tick-Borne Illness, which draws from the author's over 40 years’ experience as a holistic practitioner, Dan Kinderlehrer, MD, shares a comprehensive approach to the treatment of Lyme disease and the myriad factors that it often entails. Having had his own at-times devastating journey through Lyme disease which ultimately served as one of his greatest gifts and teachers, Kinderlehrer shares his passion, wisdom, and experience in hopes of helping others to recover their lives.”—Scott Forsgren, FDN-P, editor and founder of BetterHealthGuy.com “In his book, Recovery from Lyme Disease: The Integrative Guide to the Diagnosis and Treatment of Tick-Borne Illness, Dr. Dan Kinderlehrer outlines the controversies associated with this condition. That there remains an ongoing misconception, perpetuated by major organizations in the medical community, dismissing that the condition ‘Chronic Lyme Disease’ even exists. In this treatise, the lack of evidence for the dismissal of this condition, weighed against both animal and human studies supporting the existence of this condition, is articulated. In so doing, Dr. Kinderlehrer uses the opportunity to help validate the real nature of this entity for so many afflicted. Further, Dr. Kinderlehrer outlines a number of potential integrative interventions that may help empower individuals in the management of their own recoveries.”—Samuel Shor, MD, FACP, chair of Loudoun County Lyme Commission, past president of International Lyme and Associated Diseases Society, associate clinical professor at George Washington University Health Care Sciences “I enjoyed reading Dr. Kinderlehrer’s book. It is a well-written scientific text that provides a comprehensive review of Lyme and other tick-borne diseases. It provides the need for an updated text on the subject. It reviews thoroughly the complex subject from diagnosis to treatment and describes the controversy between the mainstream medical community and a minority of physicians described as ‘Lyme Literate Doctors' (LLD). The majority, headed by the IDSA (Infectious Diseases Society of America), don’t acknowledge the extent of those diseases, their chronicity, their impact on the American society, and the need for prolonged and multidisciplinary treatment approach for these patients. It is disappointing that a group of diseases leading to disabling neuropsychiatric diseases is managed by rheumatologists and infectious disease specialists. Dr. Kinderlehrer represents a relatively small group of physicians that through years of clinical and scientific experience have recognized the complexity of tick-borne diseases’ diagnosis and treatments. We are in an era of medical practice where patients’ conditions are broken into different disciplines and referred to specialists who not infrequently fail to communicate with each other. Dr. Kinderlehrer is one of those rare physicians capable of seeing the patient as a whole person, which is the only approach that can lead to successful management of the chronically ill complex patients. Dr. Kinderlehrer’s book represents this approach and in addition to treatments brought by allopathic medicine provides treatments offered by integrative medicine. The book is an important addition to the very much needed comprehensive literature on Lyme and tick-borne diseases. The book is a must for every open-minded practitioner. Highly recommended!”—Amiram Katz, MD “Dr. Kinderlehrer writes with the heart of a philosopher and the head of a scientist. This comprehensive book is much needed to advance our current understanding of Lyme and its related infections. Dr. Kinderlehrer presents this material in a clear and concise way that can be easily understood by both patients and clinicians. This is a must-read for anyone searching for a balanced approach to this complex, and often misunderstood, group of infections.”—Dr. Wayne Anderson, ND"In their quest to heal, patients sick with Lyme and co-infections can lose their way amidst the hopelessness of denialism, the woo of snake oil, and the frightening stories online. If you have been searching for real help, heave a sigh of relief and stop here. With the rigor of classic training in Western medicine, decades at the forefront of integrative medicine, and the sensitivity that comes from being a Lyme patient himself, the brilliant Dr. Kinderlehrer clearly and deftly rolls out the inside science of Lyme disease and the treatments and lifestyle changes, both allopathic and alternative, that have helped his patients regain their lives."—Pamela Weintraub, author of Cure Unknown: Inside the Lyme Epidemic "Dr. Dan Kinderlehrer has been on the front lines of Lyme and other tick-borne diseases for decades. He writes this book from the perspective of a physician who has the long-term responsibility of treating and helping these very challenging patients. After experiencing what he has seen with this epidemic, he has been motivated to take the responsibility to share his observations and research by writing this book. I thank Dr. Kinderlehrer for taking the time and effort to organize and share his experiences and insights to help others." —Robert C. Bransfield, MD, DLFAPA
£14.99
John Murray Press The Complex PTSD Workbook: A Mind-Body Approach
Book SynopsisThose affected by complex PTSD commonly feel as though there is something fundamentally wrong with them - that somewhere inside there is a part of them that needs to be fixed. Though untrue, such beliefs can feel extremely real and frightening. Difficult as it may be, facing one's PTSD from unresolved childhood trauma is a brave, courageous act - and with the right guidance, healing from PTSD is possible.Clinical psychologist Dr Arielle Schwartz has spent years helping those with C-PTSD find their way to wholeness. She also knows the territory of the healing firsthand, having walked it herself. This book provides a map to the complicated, and often overwhelming, terrain of C-PTSD with Dr. Schwartz's knowledgeable guidance helping you find your way.In The Complex PTSD Workbook, you'll learn all about C-PTSD and gain valuable insight into the types of symptoms associated with unresolved childhood trauma, while applying a strength-based perspective to integrate positive beliefs and behaviours.Examples and exercises through which you'll discover your own instances of trauma through relating to PTSD experiences other than your own, such as the following:* Information about common PTSD misdiagnoses such as bipolar disorder, ADHD, anxiety disorders, major depressive disorder, and substance abuse, among others.* Explorations of common methods of PTSD therapy including somatic therapy, EMDR, CBT, DBT, and mind-body perspectives.* Chapter takeaways that encourage thoughtful consideration and writing to explore how you feel as you review the material presented in relation to your PTSD symptoms.The Complex PTSD Workbook aims to empower you with a thorough understanding of the psychology and physiology of C-PTSD so you can make informed choices about the path to healing that is right for you and discover a life of wellness, free of C-PTSD, that used to seem just out of reach.Trade ReviewThis is a practical guide for all those who have experienced childhood trauma. Drawing upon her extensive practice as a body-centered psychotherapist, Dr. Schwartz has created a self-care plan that includes reflective questions and easy to use mindfulness exercises that can be implemented immediately. * Barb Maiberger, author of EMDR Essentials: A Guide for Clients and Therapists and founder of the Maiberger Institute, an EMDRIA-approved provider of EMDR Trainings *Dr. Arielle Schwartz combines simplicity, compassion, humility, and deep knowledge of the field in this book for sufferers of Complex PTSD. The Complex PTSD Workbook is an immensely useful guide to negotiating the turbulent waters of this all too common human malady. * Betty Cannon, Ph.D., author of Sartre and Psychoanalysis and Founder of Applied Existential Psychotherapy (AEP) *I highly recommend this book to anyone who struggles with childhood trauma and neglect, and their painful aftermath. Step-by-step, you will find rich resources to help yourself on your journey to wholeness. Therapists who work with both mind and body will also find this a welcoming and integrative book. * Kathy Steele, MN, CS, private practice and co-author of Treating Trauma-related Dissociation, Coping with Trauma-Related Dissociation, and The Haunted Self *The Complex PTSD Workbook offers powerful somatic therapy tools for deep healing, complemented by mindfulness strategies to increase stabilization and enhance overall wellbeing. Dr. Schwartz's emphasis on finding 'wholeness' will strengthen your resilience wherever you are in your life. * Donna Roe Daniell, LCSW, Balance Your Life Coaching & Psychotherapy, creator of the “Midlife Transition Healing Wave” and toolbox for Women in Midlife Transitions *Those who suffer from traumatic stress sometimes find beginning a personal practice intimidating. The Complex PTSD Workbook, with Dr. Arielle Schwartz as a compassionate guide, helps readers create a personal practice using yoga and mindfulness in the service of healing trauma. * Rob Schware, Executive Director, The Give Back Yoga Foundation *Healing from trauma is a profound process, one that undoubtedly involves confronting outstanding pain and suffering. In this book, Dr. Arielle Schwartz offers a unique emphasis on resilience and growth as related to Complex PTSD by providing a profoundly supportive and essential method for healing from trauma and grief. * Wendy Stern, Founder and Executive Director, The Grief Support Network *This is a comprehensive and usable guide to understanding and transforming complex trauma. Through relatable vignettes, The Complex PTSD Workbook explores trauma and treatment methods in accessible language suited for everyday use. Readers are invited to use journalling and self-reflection exercises to review and integrate what they've learned, so that the journey through the workbook is not only informational but experientially relevant as well. * J. Ryan Kennedy, PsyD, Executive Director, Noeticus Counseling Center and Training Institute *
£13.49
Nova Science Publishers Inc Zika Virus Disease: Prevention & Cure
Book Synopsis
£195.19
Nova Science Publishers Inc Advances in Health & Disease: Volume 1
Book SynopsisBariatric surgery (BS) is a set of effective surgical procedures used for weight reduction and improvement of insulin sensitivity in morbidly obese patients, in comparison with non-invasive techniques such as drug treatment or changes in lifestyle. Chapter one discusses the effects of bariatric surgery on weight and diabetes, while Chapter Two focuses on peri, postoperative and late complications. Chapter Three covers Gastroesophageal reflux disease (GERD), a disease characterised by abnormal reflux of gastric content and can be non-erosive or erosive, and the efficacy of a dietary compound containing chondroitin sulphate, aluminium hydroxide and hyaluronic acid. Chapter Four covers the role that the Transforming Growth Factor-beta family plays in the lives of metazoans, controlling key physiological processes from embryonic development to adult tissue homeostasis. In Chapter Five, the authors discuss their ongoing study on destroying food proteins that are responsible for allergy by different food processing techniques. Nickel, lead and cadmium are frequently unintentionally added to cosmetics as impurities during manufacturing. Chapter Six proposes an exhaustive focus on what metals are of interest, and what is the state of the art about analytical methodologies suitable to detect these toxic metals in cosmetics and personal care products. Chapter Seven examines the influence friend and family factors have on lifetime e-cigarette use, past year e-cigarette use, and perceptions of trying e-cigarettes soon in a national sample of Hispanic junior high and high school students.
£205.59
Nova Science Publishers Inc Enterococci & Bacterial Diseases: Risk Factors,
Book SynopsisAcute lower respiratory infections are one of the most common diseases in worldwide. Sometimes they constitute the most usual cause of death in children aged less than five years, with pneumonia like the leading origin. In Chapter One, the epidemiology (community-acquired and hospital-acquired pneumonia), causes, risk factors and clinical basic aspects of bacterial pneumonia are presented. The genus Enterococcus coexists with several Gram-positive bacteria. Chapter Two discusses how new tools must be developed to track glycopeptide resistance dissemination by using ISs as markers in epidemiological investigations across the world. Chapter Three summarises the different antibiotic resistances that are being found in enterococci isolates from food and clinical cases and also its possible relationship.
£78.39
