Diseases and disorders Books
Oxford University Press Oxford Handbook of Clinical Diagnosis
Book SynopsisThis handbook describes the diagnostic process clearly and logically, aiding medical students and others who wish to improve their diagnostic performance and to learn more about the diagnostic process.Trade ReviewThis is a nice memory aid for new clinicians as well as a refresher for clinicians who have been in the practice of medicine for a long time. * Doody's Notes *This book is useful for medical students of all years... and is perfect for ILAs, finals revision and wards round. As with all Oxford Handbooks, its handy size makes it very placement friendly. * North Wing *Table of Contents1. The diagnostic process ; 2. Interpreting the history and examination ; 3. General and endocrine symptoms and physical signs ; 4. Skin symptoms and physical signs ; 5. Cardiovascular symptoms and physical signs ; 6. Respiratory symptoms and physical signs ; 7. Gastrointestinal symptoms and physical signs ; 8. Urological and gynaecological symptoms and physical signs ; 9. Joint, limb, and back symptoms and physical signs ; 10. Psychiatric and neurological symptoms and physical signs ; 11. Laboratory tests ; 12. Chest x-rays ; 13. Making the diagnostic process evidence-based
£32.29
McGill-Queen's University Press COVID19 A History
Book SynopsisCOVID-19: A History presents a global history of the virus, with a focus on Canada. Jacalyn Duffin’s broad approach ranges from medical interventions, such as the development of tests, treatments, and vaccines, to the practical politics behind quarantines, barrier technologies, lockdowns, and social and financial supports.Trade Review“As a physician, historian, and now volunteer contact-tracer, Duffin provides a unique perspective on the history of COVID-19. This well-written and engaging book is the most detailed historical overview to date on the first waves of the pandemic in Canada and around the world.” Catherine Carstairs, University of Guelph and author of The Smile Gap: A History of Oral Health and Social Inequality“Although there is a COVID book on almost every topic, Jacalyn’s Duffin’s history instantly stands out. She has written a global history that is both measured and sophisticated. Although there will be other histories of the pandemic, I am confident that Duffin’s analysis will occupy an important place in the historiography of COVID-19 for years to come.” The American Review of Canada Studies“With verve and skill, Duffin tells a compelling story that is familiar in its big picture and new in its fine details. In the hands of most any other scholar, a short history of COVID-19 would be a blur, but in the hands of this leading medical historian, it’s a tour-de-force of smart analysis and clear writing. Among Duffin’s many strengths are her ability to draw on ancient, medieval, early modern, and modern history to deepen our understanding of the present, as well as her ability to weave different themes in and out of her text. Two stand out: scapegoating and the social determinants of health.” Literary Review of Canada
£19.94
Tellwell Talent Cancer The Pernicious Clonally Evolving Disease
Book Synopsis
£38.95
Tellwell Talent Pandemics
Book Synopsis
£44.64
Columbia University Press The Origins of Schizophrenia
Book SynopsisTrade ReviewAn excellent introduction to the origins introduction to the origins of schizophrenia, which brings together a large amount of recent work in a readable and critical manner. -- Michael Owen The British Journal of PsychiatryTable of ContentsForeword, by Robert Freedman Acknowledgments Introduction, by Alan S. Brown and Paul H. Patterson Overview: Schizophrenia and the Lifetime Trajectory of Psychotic Illness: Developmental Neuroscience and Pathobiology, Redux, by John L. Waddington, Robin J. Hennessy, Colm M. P. O'Tuathaigh, Olabisi Owoeye, and Vincent Russell Part 1. Clinical Research on Risk Factors for Schizophrenia Section 1. Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia 1. Maternal Infection and Schizophrenia, by Alan S. Brown 2. Prenatal Nutrition and the Etiology of Schizophrenia, by Kristin N. Harper and Alan S. Brown 3. Obstetric Complications and Schizophrenia: Historical Overview and New Directions, by Mary Clarke, Sarah Roddy, and Mary Cannon 4. Maternal Stress During Pregnancy and Schizophrenia, by Mary C. Iampietro and Lauren M. Ellman 5. Advancing Paternal Age and the Risk for Schizophrenia, by Sarah Crystal, Karine Kleinhaus, Mary Perrin, and Dolores Malaspina 6. Cannabis Use as a Component Cause of Schizophrenia, by Paola Casadio, Marta Di Forti, and Robin M. Murray Section 2. Genetics and Epigenetics 7. Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies?, by Alan R. Sanders, Jubao Duan, and Pablo V. Gejman 8. Genetic Architecture of Schizophrenia: The Contribution of Copy Number Variation, by Maria Karayiorgou, Rebecca J. Levy, and Bin Xu 9. The Epigenetics of Schizophrenia, by Iris Cheung, Mira Jakovcevski, and Schahram Akbarian Part 2. Preclinical Research on Etiologies of Schizophrenia Section 1. Animal Models of Environmental Factors and Schizophrenia 10. Animal Models of the Maternal Infection Risk Factor for Schizophrenia, by Paul H. Patterson 11. Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia, by Xiaoying Cui, Darryl W. Eyles, Thomas H. J. Burne, and John J. McGrath 12. Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia, by Lisa M. Tarantino, Teresa M. Reyes, and Abraham A. Palmer 13. Animal Models of the Maternal Stress Risk Factor for Schizophrenia, by Paul H. Patterson Section 2. Animal Models of Genetic Factors and Schizophrenia 14. DISC1: A New Paradigm for Schizophrenia and Biological Psychiatry, by David Porteous 15. Mutant Models of Nrg1 and ErbB4: Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia, by Yachi Chen, Lorna W. Role, and David A. Talmage List of Contributors Index
£67.20
Dorling Kindersley Ltd The Diabetes Handbook
Book SynopsisRosemary Walker worked for many years as a diabetes specialist nurse and has been at the forefront of national initiatives to improve diabetes care. Her philosophy is to acknowledge people's ability to make their own decisions about what is right for them. In 2002, she founded In Balance Healthcare UK with fellow diabetes nurse, Jill Rodgers, to provide training for people with diabetes and for health professionals, to make diabetes services more effective. Rosemary's present company, Successful Diabetes, provides information, workshops, and resources for living and working with diabetes. She is an established writer of books, articles, and comment about diabetes, including the book Diabetes: A practical guide to managing your health (DK 2004) with Jill Rodgers.
£12.99
University of Washington Press An Integrative Metaregression Framework for
Book SynopsisFirst book-length treatment of model-based meta-analytic methods for descriptive epidemiologyTable of ContentsFigures Tables Acknowledgments Introduction | by Abraham D. Flaxman, Theo Vos, and Christopher J.L. Murray 1. An Introductory Example 2. A Motivating Example 3. From Systematic Review to Metaregression 4. History of Generic Disease Modeling 5. What is Not in This Book Section One | Theory and Methods 1. Background material on Bayesian methods / Abraham D. Flaxman 1.1 A meta-analysis example 1.2 Another meta-analysis example 1.3 Summary 2. Statistical models for rates, ratios, and durations / Abraham D. Flaxman 2.1 A motivating example 2.2 Binomial model 2.3 Beta-binomial model 2.4 Poisson model 2.5 Negative-binomial mode 2.6 Transformed normal models 2.7 Lower-bound data model 2.8 Quantification of uncertainty 2.9 Comparison 2.10 Summary and future work 3. Age pattern models / Abraham D. Flaxman 3.1 Definition of spline models 3.2 Choosing knots 3.3 Penalized spline models 3.4 Augmenting the spline model 3.5 Summary and future work 4. Expert priors on age patterns / Abraham D. Flaxman 4.1 Priors on level 4.2 Priors on monotonicity 4.3 Priors are not just for splines 4.4 Hierarchical similarity priors on age patterns 4.5 Summary and future work 5. Statistical models for heterogeneous age groups / Abraham D. Flaxman 5.1 Overlapping age-group data 5.2 Midpoint model 5.3 Disaggregation model 5.4 Midpoint model with group width covariate 5.5 Age-standardizing and age-integrating models 5.6 Model comparison 5.7 Summary and future work 6. Covariate modeling / Abraham D. Flaxman 6.1 Cross-walk fixed effects to explain bias 6.2 Predictive fixed effects to improve out-of-sample estimation 6.3 Fixed effects to explain variance 6.4 Random effects for spatial variation 6.5 Covariates and consistency 6.6 Summary and future work 7. Prevalence estimates from other data types / Abraham D. Flaxman 7.1 A motivating example 7.2 System dynamics model of disease in a population 7.3 Endemic equilibrium 7.4 Forward simulation examples 7.5 Summary and future work 8. Numerical algorithms / Abraham D. Flaxman 8.1 Markov chain Monte Carlo 8.2 The Metropolis-Hastings step method 8.3 The Adaptive Metropolis step method 8.4 Convergence of the MCMC algorithm 8.5 Initial values for MCMC 8.6 A meta-analysis example 8.7 Empirical Bayesian priors to borrow strength between regions 8.8 Summary and future work 8.9 Challenges and limitations Section Two | Applications 9. Knot selection in spline models / Yong Yi Lee, Theo Vos, Abraham D. Flaxman, Jed Blore, and Louisa Degenhardt 10. Unclear age pattern, requiring expert priors / Hannah M. Peterson, Yong Yi Lee, Theo Vos, and Abraham D. Flaxman 11. Empirical priors / David Chou, Hannah M. Peterson, Abraham D. Flaxman, Christopher J.L. Murray, and Mohsen Naghavi 12. Overlapping, heterogeneous age groups / Mohammad H. Forouzanfar, Abraham D. Flaxman, Hannah M. Peterson, Mohsen Naghavi, and Sumeet Chugh 13. Dealing with geographical variation / Abraham D. Flaxman, Khayriyyah Mohd Hanaah, Justina Groeger, Hannah M. Peterson, and Steven T. Wiersma 14. Cross-walking with fixed effects / Amanda Baxter, Jed Blore, Abraham D. Flaxman, Theo Vos, and Harvey Whiteford 15. Improving out-of-sample prediction / Ali Mokdad, Abraham D. Flaxman, Hannah M. Peterson, Christopher J.L. Murray, and Mohsen Naghavi 16. Risk factors / Stephen S. Lim, Hannah M. Peterson, and Abraham D. Flaxman 17. The compartmental model / Sarah K. Wulf, Abraham D. Flaxman, Mohsen Naghavi, and Giuseppe Remuzzi 18. Knot selection in compartmental spline models / Marita Cross, Damian Hoy, Theo Vos, Abraham D. Flaxman, and Lyn March 19. Expert priors in compartmental models / Alize Ferrari, Abraham D. Flaxman, Hannah M. Peterson, Theo Vos, and Harvey Whiteford 20. Cause-specific mortality rates / Theo Vos, Jed Blore, Abraham D. Flaxman, Hannah M. Peterson, and Juergen Rehm Conclusion / Abraham D. Flaxman, Christopher J.L. Murray, and Theo Vos Appendix: GBD Study 2010 spatial hierarchy References Contributors About the editors Index
£18.99
National Academies Press Malaria Control During Mass Population Movements
Book SynopsisMalaria Control During Mass Population Movements and Natural Disasters provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.Table of Contents1 Front Matter; 2 1. Introduction; 3 2. Malaria and Mobility -- A Brief History and Overview; 4 3. Epidemiology of Malaria; 5 4. Essential Components/Design of an Optimal Malaria Control Program; 6 5. Public Health Surveillance System; 7 6. Curative Services: Malaria Therapy and Case Management; 8 7. Preventive Interventions; 9 8. Community Involvement in Malaria Control and Prevention; 10 9. Special Studies and Operational Research; 11 10. Prophylaxis and Personal Protection for Relief Workers; 12 11. Return, Repatriation, or Resettlement of Displaced Populations; 13 12. Improving Malaria Control in Complex Emergencies; 14 References; 15 Appendix A: Description of Antimalarial Drugs; 16 Appendix B: Methodology for Efficacy Assessment of In Vivo Malaria Therapy; 17 Appendix C: Alternative Treatment Regimens for Severe Malaria; 18 Appendix D: Malaria Research and Technical Resources; 19 Appendix E: About the Authors
£38.95
National Academies Press PEPFAR Implementation Progress and Promise
Book SynopsisIn 2003 Congress passed the United States Leadership Against HIV/AIDS, Tuberculosis, and Malaria Act, which established a 5-year, $15 billion initiative to help countries around the world respond to their AIDS epidemics. This book recommends that the program should focuses on the long-term strategic planning and capacity building.
£44.65
Elsevier - Health Sciences Division Nutritional Foundations and Clinical Applications
Book SynopsisTable of ContentsPART I: Wellness, Nutrition, and the Nursing Role 1. Wellness Nutrition 2. Personal and Community Nutrition PART II: Nutrients, Food, and Health 3. Digestion, Absorption, and Metabolism 4. Carbohydrates 5. Fats 6. Protein 7. Vitamins 8. Water and Minerals PART III: Health Promotion Through Nutrition and Nursing Practice 9. Energy, Weight and Fitness 10. Nutrition Across the Life Span PART IV: Overview of Medical Nutrition Therapy 11. Nutrition Assessment and Patient Care 12. Food-Related Issues 13. Nutrition for Disorders of the Gastrointestinal Tract 14. Nutrition for Disorders of the Liver, Gallbladder, and Pancreas 15. Nutrition for Diabetes Mellitus 16. Nutrition in Metabolic Stress: Burns, Trauma, and Surgery 17. Nutrition for Cardiopulmonary Disease 18. Nutrition for Diseases of the Kidneys 19. Nutrition for Neuro-Psychiatric Disorders 20. Nutrition in Cancer and HIV-AIDS Glossary Index
£72.89
Random House USA Inc Saving Milly
Book SynopsisMorton Kondracke never intended to wed Millicent Martinez, but the fiery daughter of a radical labor organizer eventually captured his heart. They married, raised two daughters, and loved and fought passionately for twenty years. Then, in 1987, Milly noticed a glitch in her handwriting, a small tremor that would lead to the shattering diagnosis of Parkinson’s disease. Saving Milly is Kondracke’s powerfully moving chronicle of his vital and volatile marriage, one that has endured and deepened in the face of tragedy; it also follows his own transformation from careerist to caregiver and activist, a man who will “fight all the way, without pause or rest, to ‘save’ his beloved Milly.” *(* Linda Bowles, The Washington Times)
£11.90
W. W. Norton & Company Psychosomatic Medicine
£19.00
John Wiley & Sons Inc The Handbook of Memory Disorders
Book SynopsisThe eagerly awaited 2nd edition of this classic handbook is a critical, thorough account of memory disorders relating to neurological processes and to developmental and acquired brain damage and presents comprehensive sections on theory, assessment, treatment and management of memory disorders.Trade Review“…incorporates several changes and additions that reflect the progress that has been made…promises to be a valuable resource…” (The Quarterly Journal of Experimental Psychology, Vol 57A(5), 2004)Table of ContentsAbout the Editors. List of Contributors. Preface. Preface to the First Edition. SECTION I: THEORETICAL BACKGROUND. The Psychology of Memory (A. Baddeley). Neurobiological Foundations of Human Memory (D. Tranel and A.Damasio). Functional Neuroimaging of Memory (M. Rugg). The Medial Temporal Lobe and Memory for Facts and Events (J. Mannsand L. Squire). Connectionist Models for Memory Disorders (J. Murre). Psychopharmacology of Human Memory (H. Curran and H.Weingartner). SECTION II: VARIETIES OF MEMORY DISORDER. The Amnesic Syndrome: Overview and Subtypes (M. O'Connor and M.Verfaillie). Theories of Anterograde Amnesia (A. Mayes). Retrograde Amnesia (M. Kopelman). Transient Global Amnesia (G. Goldenberg). Recovery of Memory Function in Neurological Disease (N. Kapur andK. Graham). Neuropsychological Impairments of Verbal Short-term Memory (G.Vallar and C. Papagano). Neuropsychological Impairments of Visual and Spatial Working Memory(S. Della Sala and R. Logie). Disorders of Semantic Memory (J. Snowden). The Cognitive Neuroscience of Confabulation: A Review and a Model(A. Gilboa and M. Moscovitch). Frontal Lobes and Memory (J. Baldo and A. Shimamura). Posttraumatic Amnesia and Residual Memory Deficit after Closed HeadInjury (H. Levin and G. Hanten). Schizophrenia (P. McKenna et al.). Memory and Emotional Disorder (T. Dalgleish and S. Cox). Psychogenic Amnesia (M. Kopelman). SECTION III: DEVELOPMENT AND MEMORY. Memory Development During the Childhood Years (S.Gathercole). Children with Intellectual Disabilities (S. Vicari and G.Carlesimo). Developmental Amnesias and Accquired Amnesias of Childhood (C.Temple). Memory in Elderly People (J. Kester et al.). The Memory Deficit in Alzheimer's Disease (J. Becker and A.Overman) Memory Disorders in Subcortical Dementia (J. Brandt and C.Munro). SECTION IV: ASSESSMENT AND MANAGEMENT OF MEMORY PROBLEMS. Assessment of Memory Disorders (B. Wilson). Separating Memory from Other Cognitive Disorders (D. Howieson andM. Lezak). Management and Remediation of Memory Problems in Brain-injuredAdults (B. Wilson). Assessment and Management of Memory Problems in Children (J.Middleton). Assessment and Intervention in Dementia of Alzheimer Type (L.Clare). Reducing the Impact of Cognitive Impairment in Dementia (B.Woods). External Memory Aids and Computers in Memory Rehabilitation (N.Kapur et al.). Emotional and Social Consequences of Memory Disorders (R.Tate). Author Index. Subject Index.
£208.76
University of California Press Who Survives Cancer
Book SynopsisHoward P. Greenwald takes an incisive look at how class, race, sex, psychological state, type of health care, and available treatments affect one's chance of surviving cancer. Drawing on a ten-year survival study of cancer patients, he synthesizes medical, epidemiological, and psychosocial research in a uniquely interdisciplinary and eye-opening approach to the question of who survives cancer and why. Scientists, health care professionals, philanthropists, government agencies, and the public all agree that significant resources must be allocated to fight this dreaded disease. But what is the most effective way to do it? Greenwald argues that our priorities have been misplaced and calls for a fundamental rethinking of the way the American medical establishment deals with cancer. He asserts that prevention and experimental therapy have only limited value, whereas the availability of conventional medical care has a greater influence on cancer survival. Class and race become strikingly significant in predicting who has access to health care and thus can obtain medical treatment in a timely, effective manner. Greenwald counters the popular notion that personality and psychological factors strongly affect survival, and he underscores the importance of early detection. His research shows that health maintenance organizations, while sometimes prone to delays, offer low-income patients a better chance of ultimate survival. Greenwald pleads for immediate attention to the inadequacies and inequalities in our health care delivery system that deter patients from seeking early medical care. Instead of focusing on research and the hope for a breakthrough cure, Greenwald urges renewed emphasis on ensuring available health care to all Americans. In its challenge to the thrust of much biomedical research and its critique of contemporary American health care, as well as in its fresh and often counterintuitive look at cancer survival, Who Survives Cancer? is invaluable for policymakers, health care professionals, and anyone who has survived or been touched by cancer. This title is part of UC Press's Voices Revived program, which commemorates University of California Press's mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1992.
£28.90
Cambridge University Press The Concepts of Illness Disease and Morbus
Book SynopsisDr Taylor's book analyses the disease concept as it developed in medical history and seeks to clarify it with the help of concepts largely derived from logical class theories. A solution is proposed to the problem of how to distinguish between the class of 'patients' and the class of 'healthy persons' which corresponds to the actual diagnostic practices of doctors. The earliest theories of disease postulated concrete entities which exist independently of the body. The notion of disease entity has lost its original ontological connotations and instead its important feature has become the possession of a unitary and self-contained character. Dr Taylor describes the modern theories as essentially 'reactive' in character, that is the symptoms of a disease are the bodily reactions to the 'noxae'. After seeing the subject in its historical content, Dr Taylor goes on to discuss in detail the notion of the classification of diseases, making extensive use of modern views on the logic of classesTable of ContentsAcknowledgements; 1. Early notions of disease; 2. Ontological theories of disease; 3. Reactive theories of disease; 4. Source indicators and their perception; 5. Classes and classifications; 6. Morbidity; 7. Morbi; 8. Molecular morbi; 9. Summary; References; Name index; Subject index.
£30.99
Access Health International A Covid Back To School Guide
Book Synopsis
£9.00
iUniverse Lost Eye Coping with Monocular Vision after Enucleation or Eye Loss from Cancer Accident or Disease
£16.67
£9.50
John Wiley and Sons Ltd Obesity
Book SynopsisThis extremely important book is the comprehensive and authoritative independent consensus report of the British Nutrition Foundation''s Task Force on Obesity. The Task Force was invited by the Council of the British Nutrition Foundation to review the present state of knowledge of the causes, consequences, prevention and treatment of obesity, and to prepare a report and should it see fit, to draw conclusions, make recommendations and identify areas for future research. Obesity is an authoritative and definitive landmark publication covering all major aspects of this vitally important condition. Bringing together a huge wealth of research information from a wide variety of disciplines, in a well-presented, clear and carefully-edited format, Obesity is an indispensable guide for all personnel involved in the prevention and treatment of obesity, or for those studying and researching in this area. The book provides comprehensive coverage of the health risks of obesity, clinical assessmTable of ContentsTerms of reference. Obesity Task Force Membership. Acknowledgements. 1. Introduction (Dr Michele Sadler). 2. Health Risks of Obesity (Professor John Garrow). 3. Clinical Assessment of Obesity (Professor John Garrow). 4. Epidemiology of Obesity in the UK (Dr Ann Gehily). 5. Aetiology of Obesity I: Introduction (Dr Andrew Prentice). 6. Aetiology of Obesity II: Genetics (Professor Peter Kopelman). 7. Aetiology of Obesity III: Critical Periods for the Development of Obesity (Dr Mary Flynn, Ms Gail Goldberg, Dr Andrew Prentice, Dr Tim Cole). 8. Aetiology of Obesity IV: Metabolic Factors (Dr Andrew Prentice). 9. Aetiology of Obesity V; Macronutrient Balance (Dr Andrew Prentice). 10. Aetiology of Obesity VI: Appetite Control, Physiological Factors (Dr Andrew Prentice, Dr James Stubbs). 11. Aetiology of Obesity VII: Endocrine Causes (Dr Nick Finer, Dr Andrew Prentice). 12. Aetiology of Obesity VIII: Psychological Factors (Professor Jane Wardle). 13. Aetiology of Obesity IX: Dietary Factors. (Dr Andrew Prentice, Dr Susan Jebb). 14. Aetiology of Obesity X: Food Choice, Food Policy and Eating Patterns (Dr David Mela, Professor Christopher Ritson, Ms Sharon Kuznesof). 15. Aetiology of Obesity XI: Physical Inactivity (Professor Kenneth Fox). 16. Significance of within Person Weight Variation (Professor John Garrow). 17. Prevention of Obesity (Professor John Garrow). 18. Treatment of Obesity I: Introduction (Professor John Garrow, Ms Mary O'Kane). 19. Treatment of Obesity II: Dietary Treatment of Obesity (Professor John Garrow, Ms Mary O'Kane). 20. Treatment of Obesity III: Physical Activity and Exercise (Professor Kenneth Fox). 21. Treatment of Obesity IV: Behavioural Treatment (Professor Jane Wardle). 22. Treatment of Obesity V: Pharmacotherapy for Obesity (Professor Peter Kopelman). 23. Treatment of Obesity VI: Surgical Treatments (Professor John Garrow). 24. Treatment of Obesity VII: Resources and Evaluation (Professor John Garrow). 25. Suggestions of Further Reading. 26. Recommendations of the BNF Task Force on Obesity. Appendix : Answers to Questions from medical journalists. Glossary. References. Index.
£73.76
Wiley Insulin Resistance
Book SynopsisInsulin resistance, defined as a reduced biological action of insulin, has emerged as a major factor in the development and progression of a number of common non-communicable diseases in man. The role of insulin resistance in the aetiology of type 2 diabetes is particularly well-established. However, insulin resistance has also come to be regarded as a key component of a broader syndrome of common metabolic defects that conspire to increase the risk of atherosclerotic coronary heart disease. The ramifications of insulin resistance now embrace many different medical specialties. The objective of this book is to summarize the current state of knowledge about insulin resistance. Section 1 (Pathophysiology of Insulin Resistance) considers the development of current concepts of insulin resistance. This is followed by a critical review of techniques for the assessment of insulin action in humans. The section concludes with an outline of current hypotheses concerning the molecular Table of ContentsSection 1. Pathophysiology of insulin resistance. . 1.1 Introduction. 1.2 Normal physiology. 1.2.1 Hormonal regulation of metabolism. . 1.2.2 The insulin receptor. 1.2.3 Post-binding events. 1.2.4 Glucose metabolism. . 1.2.5 Lipid metabolism. . 1.2.6. Protein metabolism. 1.2.7. Ion transport. . 1.3 The concept of insulin resistance. 1.3.1 Early studies of insulin action. 1.4 Definitions of insulin resistance. 1.5 Assessment of insulin action in vivo. 1.5.1 Fasting insulin concentration. 1.5.2 Dynamic tests - endogenous insulin. 1.5.3 Dynamic tests - exogenous insulin. 1.5.4 Mathematical modelling techniques. 1.5.5 The insulin suppression test. 1.5.6 The hyperinsulinaemic euglycaemic clamp technique. 1.6. Mechanisms of insulin resistance. . 1.6.1 Genetic causes of insulin resistance. . 1.6.2 Acquired causes of insulin resistance. . 1.6.3.Fetal origins hypothesis. . Further Reading. . Section 2. Insulin resistance in clinical medicine. 2.1 Clinical features. . 2.2 Factors influencing insulin sensitivity. . 2.2.1 Normal variation in insulin action. . 2.2.2 Sex. 2.2.3 Age. . 2.2.4 Physical activity. . 2.2.5 Tobacco. . 2.2.6 Alcohol. . 2.3. Physiological states of insulin resistance. 2.3.1 Puberty. . 2.3.2 Pregnancy. 2.3.4 The menopause. . 2.4 Severe insulin resistance syndromes. . 2.5 Insulin resistance and cardiovascular risk. 2.5.1 Syndrome X. 2.5.2 Obesity. . 2.5.3 Regional adiposity. . 2.5.4 Impaired glucose tolerance. . 2.5.5 Type 2 diabetes. . 2.5.6 Essential hypertension. 2.5.7 Dyslipidaemia. . 2.5.8 Endothelial dysfunction. . 2.5.9 Microalbuminuria. . 2.5.10. Hyperuricaemia. . 2.5.11 Impaired Fibrinolysis. 2.5.12 Polycystic ovary syndrome. . 2.5.13 Non-alcoholic steatohepatitis. 2.6 Other disorders associated with insulin resistance. . 2.6.1 Counter-regulatory hormone secretion. . 2.6.2 Endocrinopathies. . 2.6.3 Chronic renal failure. 2.6.4 Cirrhosis. . 2.6.5 Cardiac failure. . 2.7 Miscellaneous inherited disorders. 2.8 Drug-induced insulin resistance. Further Reading. . . Section 3. Management of insulin resistance and associated conditions. 3.1 Non-pharmacological measures. 3.1.1 Medical nutrition therapy. . 3.1.3 Alcohol. . 3.1.4 Tobacco. . 3.2 Drugs for type 2 diabetes. . 3.2.1 Biguanides. 3.2.2 Thiazolidinediones. . 3.2.3 Sulphonyulreas. . 3.2.4 Repaglinide. 3.2.5 a-glucosidase inhibitors. . 3.2.6 Insulin therapy. . 3.3 Anti-obesity drugs. . 3.4 Lipid-modifying drugs. . 3.5 Anti-hypertensive drugs. 3.6 Experimental therapies
£73.76
Harvard University Press Hermaphrodites The Medical Invention of Sex
Book SynopsisPunctuated with remarkable case studies, this book explores extraordinary encounters between hermaphrodites and the medical and scientific professionals who grappled with them in late 19th-century France and England. It takes us inside the doctors’ chambers to see how and why medical and scientific men constructed sex, gender, and sexuality.Trade ReviewIn her study of the medical response to human hermaphrodites, Alice Dreger draws on over 300 scientific and medical commentaries in France and Britain, of which over half the cases reported occurred between 1860 and 1915...As Dreger observes, there was no single opinion among doctors or the public at large about which traits were essentially male or female, or even what they might signify. In Britain, female facial hair was likely to be associated with insanity, while in France it was more likely to be seen as a mark of remarkable strength. Other interesting differences emerge...Hermaphrodites and the Medical Invention of Sex is richly researched, detailed and fascinating. -- Angelique Richardson * Times Literary Supplement *This is a well-researched, sober history of a problem that Alice Dreger shows has directly affected more people than we might think and which shapes the sense of sexual identity of us all...Avoiding preachy judgementalism, Dreger shows how deeply ingrained are our assumptions about gender normality (sexual anatomy is destiny) and on how flimsy a basis they have been grounded. The book offers us all a lesson in self-awareness. -- Roy Porter * Nature *Alice Dreger ascribes the growing visibility of the hermaphrodite to Victorian anxieties about gender-blurring social phenomena, including homosexuality and feminism, as well as to improvements in medical science. During the Victorian era, Dreger argues, a greater number of women gained access to gynecological care, and as a result, infant anatomy came under more professional scrutiny; medical journals of the period, widely accessible for the first time, publicized anomalous cases. Scientific knowledge of embryological development began turning the one-time monster or marvel into, in the words of the turn-of-the-century French doctor Xavier Delore, 'a scientific matter and a degraded organism.' -- Emily Nussbaum * Lingua Franca *Dreger...has found a rich mine in the clinical case histories of hermaphroditism, which outline the physicians' complex struggle to find a foolproof way of fitting individuals into a binary sexual scheme. -- Laurence A. Marschall * The Sciences *This engaging, well-written book will benefit scholars and lay readers interested in the history of sex, sexuality, gender, and medicine. The book traces the evolution of what makes a person male or female and shows how the answer has changed depending on when the question was asked and where it was asked. Dreger has succeeded in compelling the reader to ask the same question. -- Patricia Y. Fechner * New England Journal of Medicine *The historic records of [hermaphrodites]...are carefully documented by this meticulous author and merit study...To read this book is to become aware of the tremendous complexity of human sexuality and gender identity--beyond genitals, hormones, enzymes, and even chromosomes and genes. Behavior, feelings, and values blend with intellect and how each individual is sexually drawn to each other. -- Domeena C. Renshaw, MD * Journal of the American Medical Association (JAMA) *Most people have heard the term 'hermaphrodite,' but aren't quite sure what it means. [This book serves] as an introduction to that topic, bringing the voices of intersex people...into dialogue with...experts. Dreger also includes many fascinating historical photographs. Her stories of detective doctors presiding over 'doubtful-sex gatherings' show how 'again and again, consultations with fellow medical men almost invariably, rather than clearing up confusion, resulted instead in deeper and broader doubt...Medical men often discovered that too many diagnosers spoiled the certainty'...What makes [this book] important and provocative also makes [it] a little dangerous because [it] is so ahead of [its] time. -- Leonore Tiefer * Women's Review of Books *This is a very strange and a very good book, tackling an important topic with humanity, and in a readable style. This is a subject where biology, psychology and medical authority conflict, and where prudery, ignorance and dogmatism drive people to suicide. Dreger deals with the history of definitions of man or woman by myth and by medicine, and provides case histories, together with photographs of the problematic genitalia...As biologists, we should treasure variation--if you doubt that for human sexuality, read this book. -- Jack Cohen * Biologist *Through a collection of dramatic and moving medical case histories from the late 19th and early 20th centuries, Dreger argues that the medical profession increasingly claimed the knowledge and authority to determine 'true' gender and to effectuate such determination by surgical means...[This] is a wonderful example that historical writing is not merely about revisiting the past, but reshaping the future. This book will prove fascinating and moving reading for those concerned with the ways in which biomedical knowledge is deployed in the service of the cultural regulation of gender and sexuality. -- Vernon Rosario * Harvard Gay and Lesbian Review *[A] perceptive, erudite and superbly-written book...Concentrating on late-nineteenth- and early twentieth-century Britain and France, Dreger analyses how defining and 'managing' hermaphroditism were crucial to the destabilization as well as a simultaneous--and only seemingly paradoxical--reinforcement of the sexual division of humanity into male and female. In a surprisingly well-integrated epilogue of the book, she establishes that present-day treatment of hermaphrodites in America, in spite of phenomenal advancements in surgical technologies and theoretical understanding of sexual physiology, continues to be guided by ideas about the nature and meaning of sex that would not have seemed unfamiliar to fin-de-siècle doctors. -- Chandak Sengoopta * Medical History *In her compelling, highly engaging and carefully researched book, Dreger charts the individual stories of many hermaphrodites--often with accompanying photographs...[It is] vital reading for feminists in that [it] offers detailed illustrations of scientific and medical complicity with social norms of 'sex' and 'gender', and raises important questions about how cultures enforce ideas about 'normal' bodily conditions and behaviours. -- Celia Kitzinger * Feminism & Psychology *Dregerhas produced a well-written, lucid and sensitive account of the medical treatment of hermaphrodites from the latter half of the nineteenth century through to the present day...Dreger's description of the way modern doctors persist in assuming that they, and not the individual concerned or society, have the right to define an individual's sex are particularly illuminating. This book will be immensely interesting to historians working in this area and anyone concerned with intersexuality. -- Helen Blackman * Social History of Medicine *In her book, Alice Dreger sets out to convince the reader that the history of hermaphrodites, or people of ambiguous sex, is an important and interesting topic, and she more than accomplishes her goal. Not only does she deliver, but she does so with grace, ease, and compassion. This is a marvelous book, an unexpected surprise which is as readable and engaging as it is informative...Within pages of opening the book, I was enthralled. -- H. Hughes Evans * Journal of the History of Medicine *Traces the history of the biomedical treatment of hermaphrodites during what Dreger calls the "Age of Gonads."...She offers the reader a complex and lucid account of the process by which hermaphrodites moved from a public space (some as performers in traveling circuses and shows) to a private space where all hermaphrodite identities became increasingly shaped and defined by physicians who gained in power and prestige by intervening in the lives of these individuals...Dreger makes a convincing argument for a new approach to individuals born with ambiguous genitalia. -- Heather Harris * Journal of the History of Biology *Dreger has identified an important and suggestive topic, not only in the history of medicine, but for cultural history more generally. Hermaphrodites were, after all, only among the most striking members of the parade of anomalies that engaged the attention of both specialists and the general public at the turn of the century. Any liminal creature was apt to trigger anxieties about the defense of social as well as natural boundaries, and any breach of the barriers that divided the sexes was particularly unnerving. -- Harriet Ritvo, Massachusetts Institute of TechnologyThe casual browser who picks up this book and thinks that hermaphrodism has nothing to do with her or him is mistaken. Dreger illuminates the process by which medicine appropriated to itself the authority first to interpret and then to 'fix' sex difference. This is a specific example of a widespread but largely invisible phenomenon, in which cultural agendas are disguised as scientific authority. The medical abuse of individuals born with atypical sex anatomy in fact serves everyone who holds the unscientific belief that the world is divided neatly into two clearly distinguished sexes. Dregerhas written a book that should interest not only medical historians, professionals concerned with intersexuality, and intersexuals themselves, but everyone who thinks she knows her sex. -- Cheryl Chase, Director Intersex Society of North AmericaIn Hermaphrodites and the Medical Invention of Sex, Alice Dreger illuminates life stories that had been recast, subsumed, and ultimately 'disappeared' by the medical profession...Dreger's book is clearly written and easy to read. Fascinating, entertaining, disturbing, and thought-provoking all at once, it makes one ask, 'what is the difference between a male and a female?' and even more unsettling, 'why does it matter so much in our society.' * Synapse: University of California San Francisco Weekly *This fascinating book consists of numerous case studies on hermaphrodites (intersexes) and their abusive treatment by the medical and scientific community during the late 19th century and early 20th centuries in Britain and France... Dreger believes that by studying the cultural history and climate that prevailed relating to intersexuality at the turn of the last century, we may be better able to understand the concept of gender, sex, and sexuality. There are interesting sections on famous hermaphrodites and hermaphrodites in love. -- H.S. Pitkow * Choice *This history is important to our understanding of how the categories of "male" and "female" have come to be understood in the medical community. This history is also relevant to the current questioning of modern intersex medicine Overall, this book is well written and considers important influences of history on the treatment of hermaphrodites that have been previously ignored. -- Amy B Wisniewski, Ph.D. * The Journal of Nervous and Mental Disease *In Hermaphrodites and the Medical Invention of Sex, Alice Domurat Dreger looks at the debates concerning intersexed peole which circulated in the medical communities of France and Britain in the late 19th and early 20th centuries. In so doing, Dreger has also offered insight into our own fin-de-siècle quandaries about the limits of usefulness of the concepts of sex and gender as categorizations of human beings...Overall, Hermaphrodites and the Medical Invention of Sex is an excellent book. -- Holly Devor * Journal of Sex Research *Table of Contents* Acknowledgments * Prologue: But My Good Woman, You Are a Man! * Doubtful Sex * Doubtful Status * In Search of the Veritable Vulva * Hermaphrodites in Love * The Age of Gonads * Epilogue: Categorical Imperatives * Notes * Index
£26.31
Harvard University Press Periphery
Book SynopsisMoses Chao argues that activity in the peripheral nervous system predicts the onset of neurological and psychiatric conditions such as Parkinson’s disease, autism, and dementia. Responsible for regulating a range of involuntary bodily processes and for detecting smells, sounds, and touch, the peripheral system may also be a key to better health.Trade ReviewA sweeping tour…Chao proves to be a capable guide, and at many points it feels as if he is a personal mentor sitting at the front of a small classroom, expounding on his years of experience. -- Sara Manning Peskin * American Scientist *[An] eye-opening debut…Chao makes a convincing case that scientists would do well to focus research on the [peripheral nervous system] and its relationship with disease. * Publishers Weekly *An excellent guide to an important topic. The peripheral nervous system has long been seen as a second-class citizen with respect to the brain, but Chao shows that this is deeply misguided: without the periphery, the brain would be unable to sense the world, act in it, or even survive. -- Joseph E. LeDoux, author of The Four Realms of Existence: A New Theory of Being HumanA long-awaited book, revealing just how deeply the brain is embedded in the body. By illuminating the neuronal and humoral systems that coordinate our physiology—both with and without the brain—Chao shows that the peripheral nervous system is not at all peripheral in terms of importance. -- György Buzsáki, author of The Brain from Inside OutEngaging and well-written. Chao makes a compelling case for the role the peripheral nervous system plays in contributing to diseases that affect the central nervous system, delightfully weaving together historical accounts of neurological diseases with cutting-edge science. -- Ahmet Hoke, Director of the Division of Neuromuscular Diseases, Johns Hopkins University School of Medicine
£22.46
Hachette Books The Carpal Tunnel Helpbook
Book SynopsisThere are more than 500,000 carpal tunnel surgeries done annually in the United States but approximately 30 percent of these patients will be no better as a result. The truth is, most physicians are too quick to consider surgery as the first line of defence against carpal tunnel and other repetitive-strain injuries. In this comprehensive guide to recognizing and treating these debilitating conditions, Dr. Scott Fried takes a strong position against surgery and offers self-healing alternatives that have better results. From understanding the signs and symptoms at an early stage to modifying work and lifestyle from proven alternative therapies and helpful medications to nutrition and exercise, The Carpal Tunnel Helpbook provides authoritative advice and practical, up-to-date information to spare many patients the ordeal of surgery to treat their injuries.
£15.19
Health Communications Up the Down Escalator
Book SynopsisA memoir of triumph in the face of a terrifying diagnosis, Up the Down Escalator recounts Dr. Lisa Doggett’s startling shift from doctor to patient, as she learns to live with multiple sclerosis while running a clinic for uninsured patients in central Austin. Recounting before and after the discovery of her MS, she chronicles vexing symptoms while trying to be an attentive mother, wife, and a caring family doctor. 2024 Gold Winner, Benjamin Franklin Awards, Health & Fitness Category 2024 Silver Winner, Nautilus Book Awards, Medical Memoir Category 2024 Best of Austin in Austin Chronicle Readers Poll, Nonfiction Writer Category 2024 Winner, International Book Awards, Autobiography/Memoir Category and Health: Women''s Health Category 2024 Finalist, International Book Awards, Parenting and Family Category and Women''s Issues/Women''s Studies Category 2023 Finalist, IAN Book of the Year Awards, Non-Fiction: Health/Medicine/Fitness/Dietin
£14.41
Thomas Nelson Publishers The Great Physicians Rx for Heartburn and Acid
Book SynopsisJordan Rubin, along with Joseph Brasco, MD, is not so sure that taking antacids and powerful proton pump inhibitors best for people's healing or their health. The Great Physician's Rx for Heartburn and Acid Reflux reveals a more natural approach to beating heartburn and acid reflux based on the Seven Keys to Health and Wellness.
£7.99
Chelsea House Publishers Infectious Diseases of the Mouth Deadly Diseases
Book Synopsis
£27.16
Johns Hopkins University Press Adrenaline and the Inner World
Book SynopsisIt includes an extensive glossary.Trade ReviewThe only book you'll need to thoroughly understand the topic and its related health issues. California Bookwatch 2006 An interesting, well-written book geared to academics and professionals but also intended for patients and people supporting them. Choice 2006Table of ContentsPreface1. The Inner WorldThe Seed and the SoilCannon's CanonsThe Comfort Level in Building 10An Amazing Cooking ExperimentDeath by FootballThe Sleeper HoldSnakes That Faint?Rules of the GameSame DifferenceThe All-Day Sucker2. The "Automatic Nervous System"TransformersVeggingGood HousekeepingThe Hot LineHow Does the Autonomic Nervous System Work?3. The Arbiters of the Inner WorldThe Fat above the KidneysOn the Risk of Being a Physician's SonWhat's in a Name?Catecholamines Look Like CatsAdrenaline's Effects on the BodyNeuronal Soda PopThe Getaway Car AnalogyThe Atavistic Catecholamine"First I Secreted a Hell of a Lot of Adrenaline"A Play-Doh Model of the BrainThe Nobel Chemicals4. The Rest of the CastThe Axis PowersThe Water Works and Kosher Pickle TreatmentSalt SenseYour Own Brand of MorphineCytokinesSexLeptin5. Stress as a Scientific IdeaA Brief History of StressStress Response Patterns6. DistressCharacteristics of DistressBiblical Lie DetectionDistress versus the General Adaptation SyndromeFight Isn't FlightThe Nose of GodStressToonsStress in Evolutionary PerspectiveWhy Evolution Is a Worthwhile Theory and Creationism Isn'Darwin and EthologyThe Price of Complexity Is Eternal StressPrimitive Specificity8. DysautonomiasThe "Mind-Body" ProblemPrimary versus Secondary DysautonomiasSecondary DysautonomiasPrimary Dysautonomias9. Tests for DysautonomiasPhysiological TestsNeuropharmacological TestsNeurochemical TestsNeuroimaging Tests10. Treatments for DysautonomiasNondrug TreatmentsDrug Treatments11. Drugs and the FamilyCatecholamines as DrugsLegal AddictionsCocaineSpeed KillsMorphineBarbs and BenzosYou Aren't What You Eat, Luckily12. The Future: Scientific Integrative MedicineReturn of the Getaway CarAllostatic Load for People Who Hate SnakesThe DialecticDarwinian MedicineTactics and Strategies of Scientific Integrative MedicineWhat, How, and WhyConclusionGlossaryReferencesIndex
£31.94
Johns Hopkins University Press Mechanism Experiment Disease
Book SynopsisBertoloni Meli's critical study of this key figure and the works of his contemporaries-including Borelli, Swammerdam, Redi, and Ruysch-opens a wonderful window onto the scientific and medical worlds of the seventeenth century.Trade ReviewThe strength of Meli's work lies in his attention to detail in highly complex Latin works, and in his sensitivity to unpublished work, correspondence, diaries, and above all, to the technologies of illustration. -- William Poole Times Higher Education Distinguished as this work was, in Mechanism, Experiment, Disease Domenico Bertoloni Meli maintains there is a great deal more to Marcello Malpighi. In this new book-part biography, part intellectual history of anatomy (the philosophy and mechanics of the body), and part history of medicine in the 17th century-Bertoloni Meli tells readers why. What he does wonderfully is to locate Malpighi as a practicing physician during Italy's scientific revolution. Bertoloni Meli conveys the excitement of the new science, voices the tumult that ensued as opposing schools of thought clashed, and reminds readers that priority disputes are nothing new. JAMA Bertoloni Meli makes great use of Malpighi's wonderful epistolary consultations to remind readers that boundaries between research and practice have been drawn too sharply by historians. His use of overlooked medical correspondence increases the presence of Malpighi, the medical practitioner, working from bench to bedside four centuries before translational research hit the headlines. -- Helen Bynum JAMA The most comprehensive account to date of the works of Marcello Malpighi. -- Stephanie Eichberg The British Journal for the History of Science Bertoloni Meli's book is a very valuable and welcome contribution to the ongoing reassessment of the Scientific Revolution as a manifold process that involved all areas of natural knowledge-from physics to medicine-and reconfigured each and their mutual relations. -- Maria Pia Donato Isis Among the many lessons to be taken from Domenico Bertoloni Meli's carefully researched, persuasive and, at times, beautifully rendered book is that the life sciences in the early modern period must be studied with an eye to the history of science, medicine and philosophy... There is too much to praise and to learn from Meli's book to do it justice in a short review such as this. For several years now his work has represented a vital and inspiring force in the history medicine, and Mechanism, Experiment, Disease: Marcello Malpighi and Seventeenth-Century Anatomy in particular will enliven the study of early modern medicine in ways we cannot pretend to anticipate. But one thing we are confident about is that Meli's latest book should shape the new work to be done on eighteenth-century notions of mechanism, the emergence of pathology, and the history of visualization and its practices. -- Cynthia Klestinec and Gideon Manning MetascienceTable of ContentsAcknowledgmentsIntroduction: Anatomy, Medicine, and the New Philosophy1. Anatomical Research in the Second Half of the Seventeenth Century2. Malpighi's Role on the Anatomical Stage3. Medical Locations: The Sites of Malpighi's Work4. Mechanism and Mechanics5. Experiment and Collaboration6. Disease and Anatomy7. Structure and OrganizationPart I: The Rise of Mechanistic and Microscopic Anatomy: Malpighi's Formation and Association with Borelli1. The New Anatomy, the Lungs, and Respiration1.1. Changing Anatomical Horizons1.2. Malpighi's Bologna Apprenticeship: Anatomical Venues and Vivisection1.3. Malpighi's Pisa Apprenticeship: Microscopy and the New Philosophy1.4. Malpighi's Epistolae on the Lungs1.5. The Purpose of Respiration: Thruston, Lower, and Hooke2. Epidemic Fevers and the Challenge to Galenism2.1. Galenic Traditions and New Medical Thinking2.2. Borelli and the Sicilian Epidemics of 1647–482.3. Borelli, Malpighi, and the Pisa Epidemics of 16612.4. The 1665 Controversy between the Neoterics and the Galenists2.5. Malpighi's Risposta to Galenistarum triumphus3. The Anatomy of the Brain and of the Sensory Organs3.1. Atomism and the Anatomy of the Senses3.2. Brain Research in the 1660s: Willis, Steno, and Malpighi3.3. Malpighi's Anatomical Findings on Taste and Touch3.4. Fracassati's Far-Reaching Investigations3.5. Bellini and Rossetti: Atomistic Anatomy of Taste and TouchPart II: Secretion and the Mechanical Organization of the Body: Glands as the Centerpiece of Malpighi's Investigations4. The Glandular Structure of the Viscera4.1. The Revival of Glands4.2. Changing Perceptions on Glands: Glisson, Wharton, and Steno4.3. Malpighi's Treatise on the Liver4.4. The Brain and the Cerebral Cortex4.5. The Kidneys: Bellini and Malpighi4.6. The Spleen and Its Problems5. Fat, Blood, and the Body's Organization5.1. The Necessity of Matter and the Animal's Benefit5.2. Descartes on Fat, Blood, and Nutrition5.3. Malpighi on Fat and Its Philosophical Implications5.4. Blood Transfusions5.5. Malpighi on Heart Polyps and the Nature of Blood6. The Structure of Glands and the Problem of Secretion6.1. Different Perspectives on Glands6.2. Intestinal Glands and Their Implications6.3. The Mode of Operation of Glands6.4. Glands in the Theatre: Bellini, Sbaraglia, and Malpighi6.5. Nuck's New Taxonomy of GlandsPart III: Between Anatomy and Natural History: Malpighi andthe Royal Society7. The Challenge of Insects7.1. Changing Perceptions on Insects7.2. Redi: Experiments and Generation7.3. Malpighi: Historia and Anatomy7.4. Swammerdam: Metamorphosis and Classification7.5. Swammerdam and Malpighi: Microstructure and Iconography8. Generation and the Formation of the Chick in the Egg8.1. Generation and Its Problems8.2. Harvey: Epigenesis and the Role of the Faculties8.3. The Organs of Generation and the Problem of Fecundation8.4. Swammerdam and the Amsterdam Circle on Preformation8.5. Malpighi and the Formation of the Chick in the Egg9. The Anatomy of Plants9.1. Plants between Anatomy and Natural History9.2. Malpighi's Anatomy of Plants: Structure, Iconography, and Experiment9.3. Trionfetti, Malpighi, Cestoni, and the Vegetation of Plants9.4. Grew and Camerarius: Iconography, "OEconomy," and SexualReproductionPart IV: Anatomy, Pathology, and Therapy: Malpighi's Posthumous Writings10. The Fortunes of Malpighi's Mechanistic Anatomy10.1. Mechanistic Anatomy and Malpighi's Vita10.2. Writing about the Self10.3. Levels of Mechanical Explanation in Borelli and Malpighi10.4. Paolo Mini and the Soul-Body Problem10.5. Ruysch's Challenge and Boerhaave11. From the New Anatomy to Pathology and Therapy11.1. A Bologna Controversy and Its Wider Implications11.2. Sbaraglia's Challenge to Malpighi's Research11.3. Malpighi: The Medical Signifi cance of the New Anatomy11.4. Sbaraglia's Empiricism and Methodological Concerns11.5. Young Morgagni's Covert Intervention12. Medical Consultations12.1. Between Theory and Practice, Carnival and Lent12.2. Publishing Malpighi's Consultations12.3. Structure and Contents of Malpighi's Consultations12.4. Curing with the Pen: Francesco Redi12.5. A Broader Look at Medical Consultations: Vallisneri and MorgagniEpilogueList of AbbreviationsNotesReferencesIndex
£75.05
Johns Hopkins University Press Mechanism Experiment Disease
Book SynopsisBertoloni Meli's critical study of this key figure and the works of his contemporaries-including Borelli, Swammerdam, Redi, and Ruysch-opens a wonderful window onto the scientific and medical worlds of the seventeenth century.Trade ReviewThe strength of Meli's work lies in his attention to detail in highly complex Latin works, and in his sensitivity to unpublished work, correspondence, diaries, and above all, to the technologies of illustration. -- William Poole Times Higher Education Distinguished as this work was, in Mechanism, Experiment, Disease Domenico Bertoloni Meli maintains there is a great deal more to Marcello Malpighi. In this new book-part biography, part intellectual history of anatomy (the philosophy and mechanics of the body), and part history of medicine in the 17th century-Bertoloni Meli tells readers why. What he does wonderfully is to locate Malpighi as a practicing physician during Italy's scientific revolution. Bertoloni Meli conveys the excitement of the new science, voices the tumult that ensued as opposing schools of thought clashed, and reminds readers that priority disputes are nothing new. JAMA Bertoloni Meli makes great use of Malpighi's wonderful epistolary consultations to remind readers that boundaries between research and practice have been drawn too sharply by historians. His use of overlooked medical correspondence increases the presence of Malpighi, the medical practitioner, working from bench to bedside four centuries before translational research hit the headlines. -- Helen Bynum JAMA The most comprehensive account to date of the works of Marcello Malpighi. -- Stephanie Eichberg The British Journal for the History of Science Bertoloni Meli's book is a very valuable and welcome contribution to the ongoing reassessment of the Scientific Revolution as a manifold process that involved all areas of natural knowledge-from physics to medicine-and reconfigured each and their mutual relations. -- Maria Pia Donato Isis Among the many lessons to be taken from Domenico Bertoloni Meli's carefully researched, persuasive and, at times, beautifully rendered book is that the life sciences in the early modern period must be studied with an eye to the history of science, medicine and philosophy... There is too much to praise and to learn from Meli's book to do it justice in a short review such as this. For several years now his work has represented a vital and inspiring force in the history medicine, and Mechanism, Experiment, Disease: Marcello Malpighi and Seventeenth-Century Anatomy in particular will enliven the study of early modern medicine in ways we cannot pretend to anticipate. But one thing we are confident about is that Meli's latest book should shape the new work to be done on eighteenth-century notions of mechanism, the emergence of pathology, and the history of visualization and its practices. -- Cynthia Klestinec and Gideon Manning MetascienceTable of ContentsAcknowledgmentsIntroduction: Anatomy, Medicine, and the New Philosophy1. Anatomical Research in the Second Half of the Seventeenth Century2. Malpighi's Role on the Anatomical Stage3. Medical Locations: The Sites of Malpighi's Work4. Mechanism and Mechanics5. Experiment and Collaboration6. Disease and Anatomy7. Structure and OrganizationPart I: The Rise of Mechanistic and Microscopic Anatomy: Malpighi's Formation and Association with Borelli1. The New Anatomy, the Lungs, and Respiration1.1. Changing Anatomical Horizons1.2. Malpighi's Bologna Apprenticeship: Anatomical Venues and Vivisection1.3. Malpighi's Pisa Apprenticeship: Microscopy and the New Philosophy1.4. Malpighi's Epistolae on the Lungs1.5. The Purpose of Respiration: Thruston, Lower, and Hooke2. Epidemic Fevers and the Challenge to Galenism2.1. Galenic Traditions and New Medical Thinking2.2. Borelli and the Sicilian Epidemics of 1647–482.3. Borelli, Malpighi, and the Pisa Epidemics of 16612.4. The 1665 Controversy between the Neoterics and the Galenists2.5. Malpighi's Risposta to Galenistarum triumphus3. The Anatomy of the Brain and of the Sensory Organs3.1. Atomism and the Anatomy of the Senses3.2. Brain Research in the 1660s: Willis, Steno, and Malpighi3.3. Malpighi's Anatomical Findings on Taste and Touch3.4. Fracassati's Far-Reaching Investigations3.5. Bellini and Rossetti: Atomistic Anatomy of Taste and TouchPart II: Secretion and the Mechanical Organization of the Body: Glands as the Centerpiece of Malpighi's Investigations4. The Glandular Structure of the Viscera4.1. The Revival of Glands4.2. Changing Perceptions on Glands: Glisson, Wharton, and Steno4.3. Malpighi's Treatise on the Liver4.4. The Brain and the Cerebral Cortex4.5. The Kidneys: Bellini and Malpighi4.6. The Spleen and Its Problems5. Fat, Blood, and the Body's Organization5.1. The Necessity of Matter and the Animal's Benefit5.2. Descartes on Fat, Blood, and Nutrition5.3. Malpighi on Fat and Its Philosophical Implications5.4. Blood Transfusions5.5. Malpighi on Heart Polyps and the Nature of Blood6. The Structure of Glands and the Problem of Secretion6.1. Different Perspectives on Glands6.2. Intestinal Glands and Their Implications6.3. The Mode of Operation of Glands6.4. Glands in the Theatre: Bellini, Sbaraglia, and Malpighi6.5. Nuck's New Taxonomy of GlandsPart III: Between Anatomy and Natural History: Malpighi andthe Royal Society7. The Challenge of Insects7.1. Changing Perceptions on Insects7.2. Redi: Experiments and Generation7.3. Malpighi: Historia and Anatomy7.4. Swammerdam: Metamorphosis and Classification7.5. Swammerdam and Malpighi: Microstructure and Iconography8. Generation and the Formation of the Chick in the Egg8.1. Generation and Its Problems8.2. Harvey: Epigenesis and the Role of the Faculties8.3. The Organs of Generation and the Problem of Fecundation8.4. Swammerdam and the Amsterdam Circle on Preformation8.5. Malpighi and the Formation of the Chick in the Egg9. The Anatomy of Plants9.1. Plants between Anatomy and Natural History9.2. Malpighi's Anatomy of Plants: Structure, Iconography, and Experiment9.3. Trionfetti, Malpighi, Cestoni, and the Vegetation of Plants9.4. Grew and Camerarius: Iconography, "OEconomy," and SexualReproductionPart IV: Anatomy, Pathology, and Therapy: Malpighi's Posthumous Writings10. The Fortunes of Malpighi's Mechanistic Anatomy10.1. Mechanistic Anatomy and Malpighi's Vita10.2. Writing about the Self10.3. Levels of Mechanical Explanation in Borelli and Malpighi10.4. Paolo Mini and the Soul-Body Problem10.5. Ruysch's Challenge and Boerhaave11. From the New Anatomy to Pathology and Therapy11.1. A Bologna Controversy and Its Wider Implications11.2. Sbaraglia's Challenge to Malpighi's Research11.3. Malpighi: The Medical Signifi cance of the New Anatomy11.4. Sbaraglia's Empiricism and Methodological Concerns11.5. Young Morgagni's Covert Intervention12. Medical Consultations12.1. Between Theory and Practice, Carnival and Lent12.2. Publishing Malpighi's Consultations12.3. Structure and Contents of Malpighi's Consultations12.4. Curing with the Pen: Francesco Redi12.5. A Broader Look at Medical Consultations: Vallisneri and MorgagniEpilogueList of AbbreviationsNotesReferencesIndex
£41.50
John Wiley and Sons Ltd Functional Foods and Nutraceuticals in Cancer
Book SynopsisIncreasing numbers of people are turning to the use of dietary vegetables, medicinal herbs, and plant extracts to treat cancer. This title brings together a leading group of experts on the different aspects of nutrient supplementation, foods and plant extracts in cancer prevention and treatment.Table of ContentsContirbutors. Preface. Acknowledgments. Part I. Approaches to Cancer Prevention: Role of Nutrition. 1. Antioxidents as Cancer Therapies. 2. Cancer and Nutrition. 3. Vitimin E in Cancer Prevention and Treatment. 4. Chemical Versus Food Forms of Selenium in Cancer Prevention. 5. Nutients to Stimulate Cellular Immunity: Role in cancer Prevention and Therepy. 6. Nutrition and Skin Cancer Risk Prevention. 7. Nutritional Startegies for the Prevention of Cervical Cancer. Part II. Fruits, Vegetables, and Herbs in Cancer Prevention. 8. Tomato and Cancer. 9. The Role of Dietary Fiber in Colon cancer Prevention. 10. Soy Food and Breast cancer. 11. Prevention and Therepeutic Effects of Dietary Phytochemicals on Cancer Development. 12. Phytomedicines and Cancer Prevention. 13. Phytoesrogens and Cancer. 14. Herbals and Cancer Prevention. 15. Cruciferous Vegetables and Cancer Prevention. 16. Breast Cancer Prevention. Index.
£187.16
John Wiley and Sons Ltd Functional Foods Nutraceuticals and Degenerative
Book SynopsisFunctional Foods, Nutraceuticals and Degenerative Disease Prevention is a compilation of different segments of functional foods and nutraceuticals focusing on their mechanism of action in the human body leading to disease prevention. Numerous chapters deal with different functional foods in terms of their efficacy, highlighting the mechanism of action of their ingredients. The book focuses on the biochemistry and molecular biology of the disease prevention process rather than simply compiling the benefits of functional foods and nutraceuticals. Aimed primarily at an audience comprised of researchers, industry professionals, food scientists, medical professionals and graduate level students, Functional Foods, Nutraceuticals and Degenerative Disease Prevention offers a mechanism-based interpretation for the effect of nutraceuticals within the human body. Ultimately, the discussion of the biological effects of a variety of functional foods will provide a wholesome approTable of ContentsContributors xv Preface xvii About the Editors xix 1 Functional Foods, Nutraceuticals, and Disease Prevention: A Window to the Future of Health Promotion 3 Gopinadhan Paliyath and Kalidas Shetty 1.1 Chronic Degenerative Diseases in Modern Society: Implications on Life Quality, Productivity, Economic Burden 3 1.1.1 Diet and lifestyle changes: the missing foods 3 1.1.2 Social and economic burden of chronic degenerative diseases 4 1.2 Health Regulatory Properties of Foods: “Prevention Is Better Than Cure” 5 1.2.1 Fruit and vegetable consumption and disease prevention 6 References 8 2 Functional Foods and Nutraceuticals 11 Chung-Ja C. Jackson and Gopinadhan Paliyath 2.1 Introduction 11 2.2 Definition of Functional Foods and Nutraceuticals 12 2.2.1 Effects of functional foods and nutraceuticals on major chronic diseases 16 2.3 Sources and Biological Effects of Functional Foods and Nutraceuticals in Nature 19 2.3.1 Flaxseed (Linum usitatissimum) 20 2.3.2 Phytoestrogens 21 2.3.3 Tomatoes 21 2.3.4 Garlic (Allium sativum) 21 2.3.5 Cruciferous vegetables 22 2.3.6 Citrus fruits 22 2.3.7 Cranberry 23 2.3.8 Tea 23 2.3.9 Wine and grapes 24 2.3.10 Chocolate 24 2.3.11 Fish 25 2.3.12 Dairy products 25 2.3.13 Carbohydrates 26 2.3.14 Meat 26 2.3.15 Vitamins 26 2.3.16 Minerals 27 2.4 Functional Foods and Nutraceuticals: Health Claims and Benefits 27 2.4.1 Oats 27 2.4.2 Psyllium 27 2.4.3 Soybeans 28 2.4.4 Phytosterols 29 2.4.5 Fiber 29 2.4.6 D-Tagatose 29 2.5 Qualifi ed Health Claims 29 2.5.1 Selenium and cancer 29 2.5.2 Antioxidant vitamins and cancer 30 2.5.3 Nuts (e.g., walnuts) and heart disease 30 2.5.4 Omega-3 fatty acids and CHD 30 2.5.5 Phosphatidylserine/Phosphatidylcholine and cognitive dysfunction and dementia 30 2.5.6 Folic acid and neural tube birth defects 30 2.6 Functional Foods and Nutraceuticals: Safety Issues 30 2.6.1 Echinacea 31 2.6.2 Ephedra (also called “ma huang, herbal ecstasy, or mahuanggen”) 31 2.6.3 Feverfew 31 2.6.4 Garlic 31 2.6.5 Ginger 32 2.6.6 Gingko biloba 32 2.6.7 Ginseng 32 2.6.8 Kava kava products 32 2.6.9 St. John’s Wort 32 2.7 Regulation of Functional Foods and Nutraceuticals 33 2.8 Public Education and Dietary Guidance 35 2.9 Concluding Remarks 36 References 37 3 Nutritional Genomics: Fundamental Role of Diet in Chronic Disease Prevention and Control 45 Amy J. Tucker, Branden Deschambault, and Marica Bakovic 3.1 Introduction 45 3.2 Nutrigenetics 46 3.2.1 Gene polymorphisms 46 3.2.2 Single nucleotide polymorphisms (SNPs) 47 3.2.3 Nonsynonymous single nucleotide polymorphisms (nsSNPs) 47 3.2.4 Regulatory single nucleotide polymorphisms (rSNPs) 48 3.2.5 Splice site single nucleotide polymorphisms (ssSNPs) 48 3.2.6 Trans-Acting rSNPs 48 3.3 Complexities of chronic disease research in nutrigenetics 49 3.4 Chronic Disease and Rare SNPs 50 3.4.1 Copy number variants 50 3.5 CVD and Nutrigenetics 51 3.6 Nutrigenetics and Cancer 51 3.7 Summary of Nutrigenetic Research Potential 51 3.8 Nutriepigenetics 52 3.8.1 Role of the epigenome 52 3.8.2 Cause of epimutations 52 3.9 Epimutations in Chronic Disease 53 3.9.1 Epimutations and macronutrients/micronutrients 53 3.9.2 Epimutations and phytochemicals 54 3.10 Summary of Epigenetic Research Potential 54 3.11 Nutrigenomics 54 3.11.1 Genomic impact of diet 55 3.11.2 Carbohydrates and gene interactions 55 3.12.3 Cholesterol and gene interactions 56 3.11.4 FAs, lipids, and gene interactions 58 3.11.5 Lipids and APOE 59 3.11.6 Diet and APOE 60 3.11.7 Lipids and hepatic lipase (HL) 60 3.11.8 Diet and LIPC 61 3.11.9 Interaction between APOE and HL 61 3.12 Vitamin A and Gene Interactions 61 3.12.1 Dual roles of vitamin A 62 3.13 Vitamin E and Nutrigenomics 62 3.13.1 Vitamin E and atherosclerosis 62 3.13.2 Vitamin E and cholesterol biosynthesis 63 3.14 Vitamin D and Gene Interactions 63 3.14.1 Vitamin D and breast cancer 63 3.14.2 Vitamin D and FAs 64 3.15 Phytoestrogens and Gene Interactions 64 3.15.1 Phytoestrogens and breast cancer 64 3.15.2 Phytoestrogens and lipid, glucose metabolism 64 3.16 Phytosterols and Gene Interactions 65 3.16.1 Phytosterols and cholesterol metabolism 65 3.16.2 Phytosterols and cancer 65 3.17 Polyphenols and Gene Interactions 65 3.17.1 Polyphenols and CVD 65 3.17.2 Polyphenols and cancer 66 3.18 Nutrigenomics Summary: Advantages, Limitations, Future 66 3.19 Conclusions 67 References 67 4 Nutraceuticals and Antioxidant Function 75 Denise Young, Rong Tsao, and Yoshinori Mine 4.1 Introduction 75 4.2 Oxidative Stress and ROS 75 4.2.1 Endogenous sources of ROS 76 4.2.2 Exogenous sources of ROS 77 4.3 Antioxidants and Antioxidative Defense Systems 77 4.3.1 Endogenous antioxidants and antioxidative defenses 77 4.3.2 Dietary antioxidants 79 4.4 Phytochemicals 79 4.4.1 Polyphenols 80 4.4.2 Amides 85 4.4.3 Carotenoids 86 4.4.4 Mechanism of antioxidant action 87 4.5 Antioxidant Amino Acids, Peptides, and Proteins 90 4.6 Mechanism of Action of Antioxidant and Antioxidative Stress Amino Acids, Peptides, and Proteins 91 4.6.1 Amino acids 91 4.6.2 Peptides and proteins 91 4.7 Production of Antioxidant Peptides 95 4.8 Recent Advances in Analytical Techniques for Measuring Antioxidant Capacity and Oxidative Damage 96 4.8.1 Chemical antioxidant capacity assay 96 4.8.2 Cell-based antioxidant assays 99 4.9 Health Benefi ts of Nutraceutical Antioxidants 101 4.9.1 Evidence of antioxidant efficacy in disease states 101 4.9.2 Failure of antioxidants to demonstrate efficacy 102 4.10 Conclusion 102 References 103 5 Composition and Chemistry of Functional Foods and Nutraceuticals: Infl uence on Bioaccessibility and Bioavailability 113 Jissy K. Jacob and Gopinadhan Paliyath 5.1 Introduction 113 5.2 Polyphenols as Antioxidants 115 5.2.1 Free radicals and endogenous antioxidant defense mechanisms 115 5.2.2 Diet and exogenous antioxidants (flavonoids) 115 5.2.3 Antioxidant properties of flavonoids 117 5.3 Antioxidant Activity of Anthocyanins 118 5.4 Anthocyanin Biosynthesis and Localization 119 5.5 Bioaccessibility and Bioavailability of Polyphenols 121 5.6 Microstructural Characteristics of Grape Juice 122 5.7 Physicochemical Properties of the Dialyzed Juice Fraction 123 5.8 Ultrastructural Analysis of Juice Fractions 124 5.9 Composition of Juice Fractions 126 5.10 Antioxidant Activity of Juice Fractions 129 5.11 Metabolism and Bioavailability of Flavonoids 132 5.12 Dietary Polyphenols and Prevention of Diseases 135 5.12.1 Polyphenols and cardiovascular diseases 135 5.12.2 Polyphenols and cancer 136 5.13 Increasing Health Benefi cial Properties of Juices 137 References 139 6 Cruciferous Vegetable-Derived Isothiocyanates and Cancer Prevention 147 Ravi P. Sahu and Sanjay K. Srivastava 6.1 Introduction 147 6.2 Metabolism of Xenobiotics 149 6.3 ITCs and Inhibition of Cancer 150 6.3.1 Pancreatic cancer 150 6.3.2 Brain cancer 152 6.3.3 Prostate cancer 152 6.3.4 Lung cancer 154 6.3.5 Breast cancer 155 6.3.6 Colon cancer 156 6.3.7 Hepatic cancer 156 6.3.8 Bladder cancer 157 6.3.9 Multiple myeloma (MM) 158 6.3.10 Head and neck squamous cancer 159 6.3.11 Ovarian cancer 159 6.3.12 Skin cancer 160 Acknowledgments 161 References 161 7 The Disease-Preventive Potential of Some Popular and Underutilized Seeds 171 Rajeev Bhat 7.1 Introduction 171 7.2 Oil Seeds and Their Therapeutic Potential 172 7.2.1 Nigella seeds (Nigella sativa L.) 172 7.2.2 Sunfl ower seed (Helianthus annuus L.) 172 7.2.3 Groundnut seed (Arachis hypogea L.) 183 7.2.4 Sesame seeds (Sesamum indicum L.) 184 7.2.5 Oilseed rape (Brassica napus L.) 184 7.2.6 Saffl ower (Carthamus tinctorius L.) 184 7.2.7 Linseed (Linum usitatissimum L.) 185 7.3 Spice Seeds as Medicine 185 7.3.1 Coriander seeds (Coriandrum satium L.) 185 7.3.2 Caraway (Cumin carvi L.) 186 7.3.3 Pepper seeds (Piper nigrum L.) 186 7.3.4 Cumin seeds (Cuminum cyminum L.) 186 7.3.5 Fenugreek seeds (Trigonella foenum-graecum L.) 187 7.4 Legumes and Medicinal Use 187 7.4.1 Soybeans (Glycine max (L.) Merrill) 187 7.4.2 Mucuna pruriens L. 188 7.4.3 Tamarind seeds (Tamaridus indica L.) 188 7.5 Underutilized Seeds 189 7.5.1 Perilla (Perilla frutescens [Hassk.]) 189 7.5.2 Hunteria umbellata ([K. Schum] Hallier f.) 189 7.5.3 Microula sikkimensis (Hemsl.) 189 7.5.4 Chinese chive seeds (Allium tuberosum Rottl.) 190 7.5.5 Grape seeds (Vitis vinifera L.) 190 7.5.6 Pumpkin seeds (Cucurbita sp.) 191 7.5.7 Horse chestnut seeds (Aesculus hippocastanum L.) 192 7.6 Future Outlook 192 References 193 8 Effects of Carotenoids and Retinoids on Immune-Mediated Chronic Inflammation in Infl ammatory Bowel Disease 213 Hua Zhang, Ming Fan, and Gopinadhan Paliyath 8.1 Introduction 213 8.2 Carotenoids 213 8.3 IBDs 214 8.4 Phytochemicals and Downregulation of IBD 215 8.4.1 Antioxidative capacity of carotenoids to reduce oxidative stress generated from inflammation 215 8.4.2 Immune-modulating activity of carotenoids 216 8.5 Effects of Carotenoids on Immune Genetic Mechanism of IBD 221 8.5.1 Potential role of retinoid receptors in attenuation of inflammatory diseases 222 8.5.2 Modulation of inflammatory responses through activation of nuclear receptors containing RXR heterodimers 223 8.6 Effects of Retinoids and Carotenoids on the Oxidative Stress Signaling Pathway 226 References 229 9 Ruminant Trans Fat as Potential Nutraceutical Components to Prevent Cancer and Cardiovascular Disease 235 Ye Wang, Catherine J. Field, and Spencer D. Proctor 9.1 Introduction 235 9.2 c9,t11-CLA Isomer and Health Implications 237 9.2.1 CLA modulates carcinogenesis 237 9.3 Mechanisms of CLA Action on Cancer 245 9.4 CLA Modulates CHD Risk Factors 245 9.5 Mechanisms of CLA Action on CHD 246 9.6 Vaccenic Acid 252 9.6.1 VA modulates carcinogenesis 253 9.6.2 VA modulates CVD risk factors 253 9.7 Dairy Fat Enriched with VA and CLA 254 9.7.1 Enriched dairy fat modulates carcinogenesis 254 9.7.2 Enriched dairy fat modulates CVD risk factors 255 9.8 Discussion 255 References 256 10 Nanotechnology for Cerebral Delivery of Nutraceuticals for the Treatment of Neurodegenerative Diseases 263 Jasjeet Kaur Sahni, Sihem Doggui, Lé Dao, and Charles Ramassamy 10.1 Introduction 263 10.2 Oxidative Stress in Mild Cognitive Impairment (MCI) and AD 264 10.3 Efficacy of Selected Components of Nutraceutical Compounds in the Amyloid Cascade and in the Prevention of AD 266 10.4 Targeted NPs for Delivery of Bioactives Compounds from Foods for the Treatment of AD 272 10.4.1 Catechins coupled with NPs 272 10.4.2 NPs targeted with ApoE containing curcumin 273 10.4.3 Resveratrol-loaded NPs protect againt Aß-induced toxicity 275 10.5 Conclusion 275 References 275 11 Cancer Prevention by Polyphenols: Influence on Signal Transduction and Gene Expression 285 Fatima Hakimuddin and Gopinadhan Paliyath 11.1 Introduction 285 11.2 Genetic Mechanisms of Carcinogenesis 285 11.3 Biochemical Mechanisms of Carcinogenesis 287 11.3.1 Pathways and signals involved in neoplastic cell transformation and carcinogenesis 287 11.3.2 Extracellular signal transduction 288 11.3.3 Intracellular signal transduction 289 11.4 Signaling Pathways in Breast Cancer 291 11.4.1 Calcium homeostasis and signaling 292 11.4.2 Role of calcium in regulating cell proliferation and cell cycle 293 11.4.3 Regulation of the cell cycle by calmodulin 293 11.4.4 Calcium signaling and cell death 293 11.4.5 Mitochondria, calcium signaling, and apoptosis 294 11.5 Cancer Prevention and Therapy 294 11.5.1 Targeted therapies 294 11.5.2 Phytochemicals and cancer prevention 296 11.6 Grapes and Red Wine as a Dietary Source of Polyphenols 298 11.6.1 Health benefi ts of red wine 298 11.6.2 Modulation of signaling pathways by fl avonoids 306 11.7 Genetic Approach: Identifi cation of Flavonoid Mediated Molecular Targets 308 11.8 Estrogen Metabolism, Breast Cancer, and Flavonoids 311 11.9 Polyphenols and Estrogen Signaling 312 References 313 12 Potato–Herb Synergies as Food Designs for Hyperglycemia and Hypertension Management 325 Fahad Saleem, Ali Hussein Eid, and Kalidas Shetty 12.1 Introduction 325 12.2 Phenolic-Enriched Chilean Potato and Select Species of Apiaceae and Lamiaceae Families in Diet 327 12.3 Combination of Potato with Seeds and/or Herbs for Hypertension and Hyperglycemia Management 331 12.3.1 Chilean potato (Solanum tuberosum ssp. tubersocum L.) 331 12.3.2 Apiaceae family 333 12.3.3 Lamiaceae family 335 12.4 Conclusions: Combining the Chilean Potato with Seeds and Herbs from the Apiaceae and Lamiaceae Families 336 References 338 13 Fermentation-Based Processing of Food Botanicals for Mobilization of Phenolic Phytochemicals for Type 2 Diabetes Management 341 Chandrakant Ankolekar and Kalidas Shetty 13.1 Introduction 341 13.2 Diabetes: The Rising Burden 342 13.3 Fermentation and Health: A Historical Perspective 342 13.4 Fermentation: Adding Value 343 13.4.1 Preservation of food through acid/alcohol formation 343 13.4.2 Enrichment of food substrates through formation of micro and macro nutrients 344 13.4.3 Flavor, aroma, and texture development 344 13.4.4 Detoxification of substrates during fermentation 345 13.5 Phenolic Antioxidants and Diabetes Management 345 13.6 Microbial Aerobic Growth and Fermentation and Its Anti-Diabetes Potential by Phenolic and Antioxidant Mobilization 346 13.6.1 Solid State Growth (SSG) 346 13.6.2 Liquid state (submerged) fermentation 347 13.7 Fruit Juice Fermentation for Healthy Food Ingredients for Management of Type 2 Diabetes 348 13.7.1 Apple juice fermentation 348 13.7.2 Pear juice fermentation 349 13.7.3 Cherry juice fermentation 349 13.8 Summary 350 References 351 14 Postharvest Strategies to Enhance Bioactive Ingredients for Type 2 Diabetes Management and Heart Health 357 Dipayan Sarkar and Kalidas Shetty 14.1 Introduction 357 14.2 Changing Dietary Patterns: A Historical Perspective 357 14.3 Noncommunicable Chronic Diseases: Era of New Global Epidemics 358 14.4 Healthy Diet: “Prevention Is Better Than Cure” 360 14.4.1 Fruits and vegetables: from garden of eden to modern horticulture 360 14.5 Bioactive Ingredients 361 14.6 Dietary Polyphenols: Impact on Human Health 362 14.6.1 Role of polyphenols in glucose metabolism 362 14.6.2 Polyphenols and cardiovascular disease 364 14.7 Phenolic Biosynthesis: Biological Mechanism to Improve Dietary Polyphenols in Plant Models 365 14.8 Postharvest Strategies to Improve Bioactive Ingredients in Fruits and Vegetables 367 14.8.1 Temperature 367 14.8.2 Light and oxygen 368 14.8.3 Chemical treatment and natural compounds 368 14.9 Phenolic-Linked Antioxidant Activity During Postharvest Stages in Fruits and Relevance for Type 2 Diabetes 369 14.10 Future Direction of Research: When Functional Food and Diet Become “Panacea” 370 14.10.1 Stage 1: physiology and growth during germination to maturity 370 14.10.2 Stage 2: postharvest management 371 14.10.3 Stage 3: food processing 371 14.10.4 Stage 4: biotechnological tools 372 14.10.5 Stage 5: in vitro studies 372 14.10.6 Stage 6: animal, clinical, and epidemiological studies 372 14.10.7 Stage 7: marketing, awareness, and education 373 14.11 Conclusions 373 References 373 15 Enhancing Functional Food Ingredients in Fruits and Vegetables 381 Shaila Wadud and Gopinadhan Paliyath 15.1 Introduction 381 15.2 Strategies for Nutritional Enhancement 382 15.3 Improving the Mineral Content of Plant Foods 383 15.3.1 Iron and zinc 384 15.4 Improving the Antioxidants Content of Plant Foods 385 15.4.1 Lycopene and ß-carotene 385 15.4.2 Vitamin E 387 15.4.3 Flavonoids 387 15.5 Improving the Amino Acid Content of Proteins of Plant Foods 389 15.6 Improving the Fatty Acid Composition of Plant Seed Oil 390 15.7 Influence of Processing and Storage in the Nutritive Value of Plant Foods 391 15.7.1 Processing of plant oils 391 15.7.2 Processing of fruits and vegetables 391 References 392 Index 395
£190.90
Wayne State University Press Right Hemisphere Stroke A Victim Reflects on Rehabilitative Medicine William Beaumont Hospital Series in Speech and Language Pathology
£28.45
Duke University Press Disease in the History of Modern Latin America
Book SynopsisChallenging traditional approaches to medical history, this work advances understandings of disease as a social and cultural construction in Latin America. It provides a look at the research in the history of medicine through essays about how disease was experienced and managed in different Latin American countries and regions, at different times.Trade Review“This book is an extraordinary contribution that brings together the very best scholars of Latin American public health and social history. Its emphasis on the social conditions that lead to epidemic disease as well as the political and social forces that shape practice is a welcome corrective to a literature still too often dominated by positivist traditions.”—David Rosner, director of the Center for the History and Ethics of Public Health, Columbia University”I was fascinated by all the essays in Disease in the History of Modern Latin America. They are theoretically aware and sophisticated while they remain accessible and oriented to the complexity of historical experience. This collection is a powerful argument for the richness of an interdisciplinary approach to cultural history.”—Daniel James, author of Doña Maria's Story: Life History, Memory, and Political IdentityTable of ContentsPreface vii Disease in the Historiography of Modern Latin America / Diego Armus 1 “The Only Serious Terror in These Regions”: Malaria Control in the Brazilian Amazon / Nancy Leys Stepan 25 An Imaginary Plague in Turn-of-the-Century Buenos Aires: Hysteria, Discipline, and Languages of the Body / Gabriella Nouzeilles 51 Tropical Medicine in Brazil: The Case of Chagas’ Disease / Marilia Coutinho 76 Tango, Gender, and Tuberculosis in Buenos Aires, 1900–1940 / Diego Armus 101 The State, Physicians. and Leprosy in Modern Colombia / Diana Obregón 130 Revolution, the Scatological Way: The Rockefeller Foundation’s Hookworm Campaign in 1920s Mexico / Anne-Emanuelle Birn 158 Between Risk and Confession: State and Popular Perspectives of Syphilis Infection in Revolutionary Mexico / Katherine Elaine Bliss 183 Dying of Sadness: Hospitalism and Child Welfare in Mexico City, 1920-1940 / Ann S. Blum 209 Mental Illness and Democracy in Bolivia: The Manicomio Pacheco, 1935–1950 / Ann Zulawski 237 Stigma and Blame during an Epidemic: Cholera in Peru, 1991 / Marcus Cueto 268 Nation, Science, and Sex: AIDS and the New Brazilian Sexuality / Patrick Larvie 290 Contributors 315 Index 317
£25.19
ME - Fordham University Press Figures of Medicine
Book SynopsisIn this provocative collection of essays, François Delaporte shows how every epistemological concern demands its own mode of engagement. Through six seemingly disparate cases, Figures of Medicine reanimates the methodological and intellectual stakes at the core of the history of science and medicine.Trade Review"As always with Delaporte the scholarship is impressive, innovative and impeccable, and the analyses acute." -- -Camille Limoges Centre interuniversitaire de recherche sur la science et la technologie (CIRST-UQAM) Montreal "Lucid, focused, and rigorous ... An outstanding book that makes important contributions to intellectual history, the history of medicine, and their methodologies." -- -Jonathan Strauss Miami University
£62.90
Fordham University Press Figures of Medicine
Book SynopsisIn this provocative collection of essays, François Delaporte shows how every epistemological concern demands its own mode of engagement. Through six seemingly disparate cases, Figures of Medicine reanimates the methodological and intellectual stakes at the core of the history of science and medicine.Trade Review"As always with Delaporte the scholarship is impressive, innovative and impeccable, and the analyses acute." -- -Camille Limoges Centre interuniversitaire de recherche sur la science et la technologie (CIRST-UQAM) Montreal "Lucid, focused, and rigorous ... An outstanding book that makes important contributions to intellectual history, the history of medicine, and their methodologies." -- -Jonathan Strauss Miami University
£21.59
Taylor & Francis Inc Colorectal Cancer
Book SynopsisWritten by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.Table of ContentsGenetic Susceptibility to Colorectal Cancer. Epidemiology of Colorectal Cancer. Colorectal Cancer Screening. Pathology. Familial Cancer Management. The Surgical Principles of Managing Colorectal Cancer. Adjuvant Therapy for Colorectal Cancer. The Role of Radiotherapy in the Treatment of Rectal Cancer. Hepatic Directed Therapy. Pharmacogenomics of Colorectal Cancer. Drug Development for Advanced Colorectal Cancer in the U.S.
£171.00
Taylor & Francis Inc Molecular Interventions in LifestyleRelated
Book SynopsisThe Japanese Ministry of Health, Labor and Welfare, officially recognizing that various risk factors for disease are present in our environment, has proposed the concept of lifestyle-related diseases. These include those diseases that are tied to such lifestyle choices as excessive alcohol consumption, cigarette smoking, exposure to stress, and poor diet.Ongoing attention to this issue led to an International Symposium on Free Radicals and Health: Molecular Interventions and Protection of Lifestyle-Related Diseases bringing together the top experts in that area. With the belief that the recognition of the occurrence of risk factors and their identification are important to overcoming lifestyle-related diseases, three of those experts invited prominent participants at the symposium to contribute to a book. Molecular Interventions in Lifestyle-Related Diseases is the result of that effort.This book is divided into three main sections:Free Radicals, Lifestyle-Related DTable of ContentsFree Radicals, Lifestyle-Related Diseases, and Their Protection. Free Radicals, Brain Diseases, and Their Protection. Nutraceuticals, Functional Foods, Micronutrients, and Pharmacological Interventions.
£266.00
CABI Publishing Worms and Human Disease
Book SynopsisThis second edition of the popular advanced student textbook (previously published as Worms and Disease: A Manual of Medical Helminthology) has been thoroughly updated and revised since it was first published in 1975. It includes contributions and a chapter by Prof. Derek Wakelin, University of Nottingham, UK. An authoritative handbook covering all human helminth infections with particular emphasis on diagnosis, treatment, clinical manifestations, pathogenesis, epidemiology and control. Practical guidelines are given for estimating the clinical and public significance of helminthiases, vital in areas where the majority of inhabitants are infected with many helminths but only a few are sick.Table of Contents1: The Trematodes 2: The Cestodes 3: The Acanthocephalans 4: The Nematodes 5: Oher Groups 6: Immunology of Helminths 7: Epidemiological Aspects of Helminth Infections 8: Helminthological Techniques
£52.15
CABI Publishing Diseaserelated Malnutrition
Book SynopsisDisease-related malnutrition is a global public health problem. The consequences of disease-related malnutrition are numerous, and include shorter survival rates, lower functional capacity, longer hospital stays, greater complication rates, and higher prescription rates. Nutritional support, in the form of oral nutritional supplements or tube feeding, has proven to lead to an improvement in patient outcome. This book is unique in that it draws together the results of numerous different studies that demonstrate the benefits of nutritional support and provides an evidence base for it. It also discusses the causes, consequences, and prevalence of disease-related malnutrition, and provides insights into the best possible use of enteral nutritional support.Table of Contents1: Scientific criteria for defining malnutrition 2: Prevalence of disease-related malnutrition 3: Causes of disease-related malnutrition 4: Consequences of disease-related malnutrition 5: Framework for establishing an evidence base for nutritional intervention 6: Evidence base for oral nutritional supplements 7: Evidence base for enteral tube feeding 8: Combined analysis of the effects of oral nutritional supplements and enteral tube feeding 9: Parenteral nutrition: a comparison with enteral tube feeding 10: Undertaking clinical nutrition intervention trials 11: Conclusions 12: Appendices 13: References
£174.02
John Libbey & Co Liver Regeneration
Book Synopsis
£21.59
Taylor & Francis Ltd Feeding and Swallowing Disorders in Dementia
Book SynopsisThis informative manual draws on expert research to highlight the feeding and swallowing difficulties that can occur with dementia. It is also a practical guide that offers potential strategies to manage these problems. Professionals are encouraged to focus on the needs of the individual by providing practical questions that should be asked when making an assessment. This is achieved through a step-by-step process, which allows a worker to observe, document and manage feeding and swallowing difficulties. Forms, schedules and checklists that can be photocopied are provided to aid in implementation. This is a detailed, practical resource which offers support and direction for speech and language therapists, and others with an interest in swallowing problems, working with people with dementia. It includes case studies to illustrate theory in practice, as well as a wide ranging bibliography.Trade Review"A detailed, extremely practical book ... This book’s value is in its thorough treatment of this often complex area of clinical work ... undoubtedly a valuable source of information." — RCSLT Bulletin"This practical, spiral-bound book is a popular and useful text ... recommended to neuroscience nurses ... should be in every nursing library." — British Journal of Neuroscience Nursing"Comprehensive and easy to use text...this is a well presented, easy to read, comprehensive text; a must for any clinician working in the field." — International Journal of Geriatric Psychiatry"This manual draws on research to highlight the feeding and swallowing difficulties that may accompany dementia...needs assessment is guided by a discussion of a wide range of sensory, psychomotor, neurological and emotional factors." — Exceptional Child Educational Resources"She has produced a detailed, extremely practical book...This book’s value is in its thorough treatment of this often complex area of clinical work." — Bulletin"The Layout is clear and concise; it provides good value for money and is defiantly a practical reference." — Speech & Language Therapy on Practice"The book provides a balanced mix of theory and practice. All professionals will find the assessment forms and case studies useful. There is an excellent section on the ethics of tube feeding in severe dementia...The book advocates a team approach, which is reflected by the fact that all health professionals will find it a useful addition to their libraries." — Therapy Weekly"The book is well-structured and useful for therapists who are interested in this area of practice." — British Journal of Occupational TherapyTable of ContentsList of Tables, Acknowledgements, About the Author, Introduction, 1 Dementia, 2 Production and Use of this Resource Pack, 3 History-Taking – Feeding and Swallowing Problems, 4 Assessment and Management of Feeding and Swallowing, 5 Assessment Profiles, 6 Management Strategies – Checklists, Bibliography
£46.54
John Wiley and Sons Ltd Obesity American Heart Association Monograph
Book SynopsisObesity is becoming increasingly prevalent in a worldwide context, and has been recognised as a major contributing factor in heart disease. This volume was authored by the participants in a 1998 AHA sponsored conference on the impact of obesity on cardiovascular disease. The three main sections of the book set out to evaluate current research pertaining to causation and cardiovascular sequela of obesity. Part I defines obesity, exploring its epidemiology, its genetic and non-genetic influences and its contribution to the problem of cardiovascular disease. Special attention is given to the primary prevention of obesity as a means of avoiding specific sequelae as well as the difficulties experienced by those who try to lose weight. Part II deals with the relatively new and much heralded discovery of obesity related genes the current state of diet drugs and valvular heart disease, and the interaction of obesity and metabolism, hormonal regulation and various other biological systems. RTrade Review"This is a superb and needed book."—American Journal of Cardiology "This book may best be considered an excellent update on obesity."—Texas Heart Institute Journal "Excellent Four Stars. A comprehensive review of an important clinical area in which treatment options are badly needed."—Mayo Clinic ProceedingsTable of ContentsContributors. Acknowledgement. Preface. (S.M. Grundy). Part 1: Epidemiology of Obesity. Chapter 1. Epidemiology of Obesity in Adults in Relationship to Cardiovascular Disease. (L.H. Kuller). Chapter 2. Obesity in Children, Adolescents and Families. (E. Obarzanek). Chapter 3. Developmental Aspects of Obesity: Genetic Influences. (T.L. Burns). Chapter 4. Developmental Aspects of Obesity: Nongenetic Influences. (L.L. Hayman). Chapter 5. Prevention of Obesity. (S.R. Daniels). Part 2: Pathophysiology of Disease. Chapter 6. Obesity Related Genes. (R.M. Krauss). Chapter 7. Diet Drugs and Valvular Heart DIsease. (G.P. Aurigemma). Chapter 8. Mechanisms of Obesity Hypertension and Relevance to Essential Hypertension. (J.E. Hall, M.W. Brands, D.W. Jones, E.W. Shek, J. Henegar). Chapter 9. Obesity and Lipoprotein Metabolism: Relationship to Cardiovascular Disease. (B.V. Howard). Chapter 10. Is Insulin Resistance and Independent Risk Factor for Coronary Heart Disease? (S.M. Grundy). Chapter 11. Obesity and Postmenopausal Women. (K.M. Newton). Chapter 12. Late Breaking Advances in the Biological Understanding of Obesity and its Sequelae. (R.H. Eckel). Part 3: Assessment, Interventions, Treatment and Outcomes. Chapter 13. Body Composition Assessment: Epidemiological, Clinical and Research Tools. (M.E. Sweeney). Chapter 14. Dietary Strategies: Issues of Diet Composition. (S.T. St. Jeor, J.M. Ashley). Chapter 15. Energy Expenditure and Obesity. (J.O. Hill, Adamandia D. Kriketos). Chapter 16. Physical Activity in the Management of Obesity: Issues and Implementation. (M.L. Stefanick). Chapter 17. Efficacy and Safety of Pharmacological Interventions for the Overweight Patient. (G.A. Bray). Chapter 18. Behavioural Interaction. (J.P. Foreyt, W.S. Carlos Poston). Chapter 19. Strategies to Enhance Compliance to Weight-Loss Treatment. (L.E. Burke). Chapter 20. Quality of Life and Obesity. (M.R. Kinney). Chapter 21. Economic Impact of Obesity and its Cardiovascular Sequelae in Managed Care Settings. (K. McManus). Summary. (G.F. Fletcher). Index.
£106.35
John Wiley and Sons Ltd Vascular Dementia
Book SynopsisSummarizes concepts concerning the epidemiology, etiology, risk factors, neuropathology and pathogenesis of Vascular dementia (VAD) and Alzheimer's disease (DAT), and mixtures of the two, and reviews their multiple causes, including microvascular and hemorrhagic lesions, and ischemic and inflammatory changes affecting both white and gray matter.Table of ContentsContributors iii Foreword Honorary editor: James F. Toole, President of World Federation of Neurology ivPreface Editors: John S. Meyer, Gaiane M. Rauch, Helmut Lechner, Carlo Loeb, James F. Toole vi Chapter 1 Epidemiology of Vascular Dementia 1Md. Anwarul Haque, John S. Meyer, Gaiane M. Rauch Chapter 2 Cardiovascular Risk Factors Contributors to Cerebral Degenerative Changes, Cognitive Decline, and Dementia 19John S. Meyer, Gaiane M. Rauch, Ronald A. Rauch Chapter 3 Risk Factors for Vascular Dementia 41Helmut Lechner Chapter 4 Neuropathological Correlates of Vascular Dementia 59Carlo Loeb Chapter 5 Microvascular Pathology in Vascular and Related Dementias 77Alberto Portera-Sanchez, Jesus Porta-Etessam Chapter 6 Recent Advances in Vascular Dementia Research 101David W. Desmond Chapter 7 Clinical Feautures of Patients with Vascular Dementia Versus Alzheiner’s Disease 119Gaiane M. Rauch, john S. Meyer Chapter 8 Neuropsychological Assessments for Cognitive Decline 131Md. Anwarul Haque, John S. Meyer, Gaiane M. Rauch Chapter 9 Subcortical Arteriosclerotic Encephalopathy Binswanger Type or Chronic Microvascular Leukoencephalopathy Syndrome 155Carlo Loeb Chapter 10 Criteria for Diagnosis of Vascular Dementia 181Carlo Loeb, John S. Meyer, Gaiane M. Rauch Chapter 11 Classification of Subtypes of Vascular Dementia Including Subcortical Versus Cortical Dementias 203John S. Meyer, Gaiane M. Rauch Chapter 12 Neuroimaging in Vascular Dementia 221John S. Meyer, Gaiane M. Rauch. Ronald A. Rauch Chapter 13 Clinical Observation During Long-Term Follow-Up of Outcome in Vascular Dementia 235Helmut Lechner, Gotz Bertha Chapter 14 Prevention and Treatment of Vascular Dementia 251John S. Meyer, Gaiane M. Rauch Chapter 15 Scientific Basis for Plasmapheresis in Vascular Dementia 263Helmut Lechner Chapter 16 Estrogen Therapy for Prevention of Dementia in Postmenopausal Women 279Gaiane M. Rauch, John S. Meyer Chapter 17 Factors Influencing Long-Term Survival Among Patients with Vascular Dementia Versus Alzheimer’s Disease 289John S. Meyer, Gaiane M. Rauch Index 307
£180.86
John Wiley and Sons Ltd Cerebrovascular Disease American Heart
Book SynopsisIn this book, an international group of investigators from a broad array of clinical and basic disciplines present the ideas and concepts in the foreground of cerebrovascular disease. Included in their discussion are perspectives on topics that continue to guide current investigations.Trade ReviewFive Stars ***** "This book should be on the shelf of anyone caring for patients with stroke or who are involved in its diagnosis and treatment as it offers the most up-to-date review of the scientific basis for the decision process. The book cannot be compared to any other book in the field as it is the compilation of papers delivered at a conference where a broad range of clinical and basic science topics are covered. This, like all editions of the Princetion Conference Proceedings, should be cherished." Doody's Review Service: Cathy M. Helgason, MD, University of Illinois at Chicago College of MedicineTable of ContentsSECTION I. Extracranial-Intracranial Bypass Surgery: Time for a New Clinical Trial?. Chapter 1. Overview. Ralph G. Dacey Jr., MD and William J. Powers, MD. Chapter 2. Cerebral Hemodynamics and Stroke Risk. Robert L. Grubb Jr., MD, Colin P. Derdeyn, MD, Susanne Fritsch, RN, William J. Powers, MD. Chapter 3. Extracranial-Intracranial Bypass: Surgical Considerations. Marc R. Mayberg, MD. Chapter 4. Extracranial-Intracranial Surgery for Patients with Proven Hemodynamic Compromise: Is There Sufficient Evidence for a Second-Phase EC/IC Trial?. Henry J.M. Barnett, MD. SECTION II. Mediators and Modulators of Ischemic Injury: Hot Topics. Chapter 5. Poly(ADP-ribose) Polymerase in Ischemia-Reperfusion Injury. Valina L. Dawson, PhD and Ted M. Dawson, MD, PhD. Chapter 6. Superoxide Dismutase in Cerebral Ischemia. Pak H. Chan, PhD. Chapter 7. Estrogen as Neuroprotectant in Stroke. Patricia D. Hurn, PhD, Nabil J. Alkaayed, MD, PhD, Barbara J. Crain, MD, PhD, Valina L. Dawson, PhD, Ted M. Dawson, MD, PhD, Allen S. Mandir, MD, PhD, Renata Rusa, MD, Kenji Sampei, MD, Masahiko Sawada, MD, Thomas J.K. Toung, MD, Richard J. Traystman, PhD. Chapter 8. HMG-coAReductase Inhibitors Reduce Cerebral Infarct Size by Upregulating Endothelial Nitric Oxide Synthase. Matthias Endres, MD, Ulrich Laufs, MD, James K. Liao, MD and Michael A. Moskowitz, MD. SECTION III. White Matter Ischemia - Unique Mechanisms of Injury?. Chapter 9. Ischemic Injury to the Cerebral White Matter: Neuropathology of Human and Experimental Lesions. Leonardo Pantoni, MD, and Julio H. Garcia, MD (deceased). Chapter 10. Approaches to the Study of the Cellular and Molecular Pathogenesis of Perinatal White Matter Injury. Stephen A. Back, MD, PhD. Chapter 11. White Matter Ischemia: Unique Mechanisms of Injury. Peter K. Stys, MD. Chapter 12. CADASIL: What can we Learn about White Matter Stroke?. Marie-Germaine Bousser, MD, Hugues Chabriat, MD, Anne Joutel, MD and Elizabeth Tournier-Lasserve, MD. SECTION IV. Inflammation. Chapter 13. Introduction. John M. Hallenbeck, MD. Chapter 14. Infection and Stroke Risk. Mark Fisher, MD. Chapter 15. The Extracellular Matrix and Focal Cerebral Ischemia. Gregory J. del Zoppo, MD. Chapter 16. Some Principles of the Inflammatory Reaction to Brain Ischemia: Sense and Purpose. Julie A. Ellison, PhD, Franc C. Barone, PhD and Giora Feuerstein, MD. Chapter 17. Reperfusion Damage in the Brain. Ping-An Li, MD, PhD, Tibor Kristian, PhD, Yi-Bing Ouyang, PhD and Bo K. Siesjö, MD, PhD. Chapter 18. Debate: Heparin Should Be Used to Treat Patients Presenting with Acute Stroke or Stroke-in–Evolution: Affirmative Position. Louis R. Caplan, MD. Chapter 19. Debate: Antiocoagulation in Acute Ischemic Stroke: Not Indicated. Roger P. Simon, MD and William J. Powers, MD. SECTION V. Beyond Diffusion: Imaging Measurements of Cerebral Blood Flow and Metabolism. Chapter 20. Overview. Justin A. Zivin, MD, PhD and Marc Fisher, MD. Chapter 21. Measuring Oxygen Saturation Using Magnetic Resonance Imaging. E. Mark Haacke, PhD, Weili Lin, MD, Benjamin Lee, MD, Daniel Kido, MD, Chung Y. Hsu, MD and William J. Powers, MD. Chapter 22. Quantitative Measurement of Regional Blood Flow by Magnetic Resonance with Arterial Spin Tagging. Alan C. McLaughlin, PhD, Frank Q Ye, PhD, Venkata S. Mattay, MD, Joseph A. Frank, MD, Daniel R. Weinberger, MD. SECTION VI. Delayed Neuronal Death. Chapter 23. The GluR2 Hypothesis of Ischemia-Induced Damage: Implications for Neuroprotection and Rescue. Domenico E. Pellegrini-Giampietro, MD, PhD, Keiji Oguro, MD, PhD, Thoralf Opitz, PhD, Agata Calderone, MD, Michael V.L. Bennett, PhD and R. Suzanne Zukin, PhD. Chapter 24. Fluorescent Indicator Measurements of Ca2+ Homeostasis in Postischemic CA1 Hippocampal Neurons. John A. Connor, PhD, Anders C. Greenwood, PhD, Seddigheh Razani-Boroujerdi, PhD, Jeffrey J. Petrozzino, PhD and Rick C.S. Lin, PhD. Chapter 25. Delayed Neuronal Death: A Perspective and Synthesis. Myron D. Ginsberg, MD. SECTION VII. Cortical Reorganization and Post-Acute Stroke Treatment. Chapter 26. Introduction. Alexander W. Dromerick, MD and Larry B. Goldstein, MD. Chapter 27. Functional Remodeling of Motor Cortex after Stroke. Randolph J. Nudo, PhD, Jeffrey A. Kleim, PhD and Kathleen M. Friel, MD. Chapter 28. Growth Factors and Stroke Recovery. Jing Mei Ren, MD, John Markman, MD, and Seth P. Finklestein, MD. Chapter 29. Activity-Associated Growth Factor Expression and Related Neural Events in ecovery of Function after Brain Injury. Timothy J. Schallert, PhD, J. Leigh Humm, MA, Sondra Bland, BA, Theresa Jones, PhD, Bryan Kolb, PhD, Jaroslaw Aronowski, PhD and James Grotta, MA. SECTION VIII. Clinical Treatment Trials. Chapter 30. Recent Clinical Trials of Neuroprotective Agents and Thrombolytic Therapy for Acute Stroke. Gregory W. Albers, MD. Chapter 31. Debate: MRI is a Good Endpoint for Determining the Efficacy of Stroke Treatment Trials: Affirmative position. Steven J. Warach, MD, PhD. Chapter 32. Debate: MRI is a Good Endpoint for Determining the Efficacy of Stroke Treatment Trials: Arguments against. Joseph P. Broderick, MD
£166.46
Lifelight Publishing A Beginnerss Guide to MECFS
£7.29
Laughing Grape Publishing Stoppa sköldkörtelskandalen
£22.18
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