Clinical and internal medicine Books
Verlag Unser Wissen Patientensicherheit und Qualität der Pflege -
Book Synopsis
£36.10
Edicoes Nosso Conhecimento Terapia Ocupacional em Neurorreabilitação
Book Synopsis
£33.25
Jaypee Brothers Medical Publishers Manual of ICU Procedures
Book SynopsisManual of ICU Procedures is a comprehensive, step-by-step guide to intensive care procedures. The book is divided into four anatomical sections, and a final miscellaneous section. Section one covers airway and respiratory, followed by; vascular and cardiac; neurological; gastrointestinal, abdominal, and genitourinary procedures. Each section covers an extensive range of procedures, and each chapter begins with basic principles before describing the procedure step-by-step. Enhanced by 428 colour images and illustrations, Manual of ICU Procedures is an ideal resource for all critical care professionals. Key Points Step-by-step guide to a range of intensive care procedures Covers respiratory, cardiovascular, neurological, gastrointestinal, genitourinary and miscellaneous procedures 428 colour images Table of ContentsSection 1 Airway and Respiratory Procedures Bag-Mask Ventilation Endotracheal Intubation Laryngeal Mask Airway Insertion Fiberoptic Intubation Video Laryngoscopy Double Lumen Endotracheal Tube Cricothyroidotomy Percutaneous Tracheostomy Surgical Tracheostomy Bronchoscopy Bronchoalveolar Lavage (BAL) and Mini-BAL Thoracentesis Tube Thoracostomy Non-invasive Ventilation for Acute Respiratory Failure Aerosol Drug Delivery Prone Positioning Manual Chest Physiotherapy in Ventilated Patients Section 2 Vascular and Cardiac Procedures Venous Cannulation: Peripheral Venous Cannulation: Central Venous Catheter Venous Cannulation: Peripherally Inserted Central Catheter Tunneling of Central Venous Catheter Intraosseous Cannulation Umbilical Vascular Catheterization Arterial Blood Sampling and Cannulation Pulmonary Artery Catheterization Transducer and Pressure Monitoring Pericardiocentesis Electrical Cardioversion Temporary Cardiac Pacing Intra-aortic Balloon Pump Counterpulsation Tourniquet for Vascular Injuries Section 3 Neurological Procedures Jugular Venous Oximetry Lumbar Puncture Epidural Analgesia Cranial Burr Hole External Ventricular Drainage Intracranial Pressure Monitoring Nerve and Muscle Biopsy Spine Immobilization in Trauma Patient Section 4 Gastrointestinal/Abdominal/Genitourinary Procedures Nasogastric Tube Placement Nasojejunal Tube Placement Percutaneous Endoscopic Gastrostomy Balloon Tamponade in Upper GI Bleed Gastric Lavage Intra-abdominal Pressure Monitoring Paracentesis Percutaneous Abdominal Drain Bedside Laparoscopy Dynamic Abdominal Wall Closure for Open Abdomen Urethral Catheterization Suprapubic Cystostomy Peritoneal Dialysis Catheter Placement Hemodialysis Section 5 Miscellaneous Bone Marrow Aspiration and Biopsy Postmortem Organ Needle Biopsy Managing Pressure Ulcers Mobilization of Patient Surveillance of ICU-acquired Infection Blood and Urine Sampling for Microbiology Blood Component Handling at Bedside Managing Needle-Stick Injury Index
£999.99
Jaypee Brothers Medical Publishers Color Atlas of Retina & Optic Nerve
Book SynopsisThis atlas is a practical guide to the diagnosis of common retina and optic nerve disorders. Comprising more than 500 archetypal images, each disease is clearly illustrated showing clinical features and signs, from its early to later stages. The images are followed by a brief description highlighting key characteristics of the disease, providing clinicians with a comprehensive overview and enabling them to diagnose ocular conditions with ease. Divided into 15 sections, the book begins with an introduction to the ‘normal’ fundus. The following sections examine different retinal disorders, from retinal degeneration, uveitis, and infections, to traumatic chorioretinopathy and optic disc anomalies. The atlas concludes with chapters on ocular oncology and complications of surgery. A complete section is dedicated to paediatric retinal diseases. Table of Contents NORMAL FUNDUS RETINAL DEGENERATIONS AND DYSTROPHIES PAEDIATRIC RETINAL DISEASES RETINAL VASCULAR DISEASE CHOROIDAL VASCULAR/BRUCH'S MEMBRANE DISEASE CENTRAL SEROUS CHORIORETINOPATHY INFLAMMATORY DISEASE/UVEITIS INFECTIONS EPIRETINAL MEMBRANE, VITREOMACULAR TRACTION, MACULAR HOLE VITREOUS DEGENERATION TRAUMATIC CHORIORETINOPATHY PERIPHERAL RETINAL DEGENERATIONS AND RHEGMATOGENEOUS RETINAL DETACHMENT OPTIC DISC ANOMALIES AND DISEASES ONCOLOGY COMPLICATIONS OF OCULAR SURGERY
£77.90
Jaypee Brothers Medical Publishers Medical Emergencies in General Practice
Book SynopsisTable of ContentsChapter 1: Cardiovascular Emergencies Chapter 2: Respiratory Emergencies Chapter 3: Gastrointestinal Emergencies Chapter 4: Neurological Emergencies Chapter 5: Renal Emergencies Chapter 6: Hematological Emergencies Chapter 7: Endocrinal and Metabolic Emergencies Chapter 8: Emergencies in Infectious and Tropical Diseases Chapter 9: Acute Poisoning Chapter 10: Iatrogenic Emergencies Chapter 11: Shock Syndrome and Critical Allergic Reactions Chapter 12: Environmental Emergencies Chapter 13: Miscellaneous Emergencies
£15.00
Jaypee Brothers Medical Publishers KNV's Manual of Clinical Neurology
Book SynopsisTable of ContentsCHAPTER 1: History Taking in Neurology CHAPTER 2: Examination of the Nervous System CHAPTER 3: Disorders of the Visual Pathway, Pupillary Abnormalities, and Abnormalities of Extraocular Movements CHAPTER 4: Nystagmus CHAPTER 5: Disorders of Trigeminal Nerve (Vth Cranial Nerve) CHAPTER 6: Disorders of the Facial Nerve (VIIth Cranial Nerve) CHAPTER 7: Examination of VIIIth and Lower Cranial Nerves CHAPTER 8: Cerebrovascular Diseases/Stroke CHAPTER 9: Localization of Spinal Cord Disorders CHAPTER 10: Disorders of Peripheral Nerves CHAPTER 11: Motor Neuron Disease CHAPTER 12: Involuntary Movements CHAPTER 13: Parkinsonism and Wilson’s Disease CHAPTER 14: Demyelinating Diseases of the Nervous System CHAPTER 15: Cerebellar Syndromes CHAPTER 16: Spinocerebellar Ataxias CHAPTER 17: Craniovertebral Anomalies CHAPTER 18: Diseases of Muscle and Neuromuscular Junction CHAPTER 19: Disturbances of Speech CHAPTER 20: Headaches and Craniofacial Pains CHAPTER 21: Epilepsy CHAPTER 22: Approach to a Comatose Patient and Narcolepsy CHAPTER 23: Neurocutaneous Markers (Phakomatoses) CHAPTER 24: Urinary Bladder Innervation and Dysfunctions CHAPTER 25: Abnormalities of Gait CHAPTER 26: Brachial Plexus and its Lesions CHAPTER 27: Dysfunctions of the Cerebral Hemispheres CHAPTER 28: Hepatic Encephalopathy and Herpes Simplex Virus Encephalitis CHAPTER 29: Dementias CHAPTER 30: Neurologic Manifestations in Rheumatic Diseases CHAPTER 31: Atlas of Fundus Photographs CHAPTER 32: Neurosyphilis: Recent Trends
£55.10
Jaypee Brothers Medical Publishers Contemporary Topics in Critical Care Medicine
Book SynopsisTable of ContentsSECTION 1: Airway Management — Current Controversies 1. Can Sellick Maneuver Prevent Pulmonary Aspiration in the Critically Ill? 2. Etomidate vs. Ketamine — What Should We Use for Intubation in ICU SECTION 2: Extracorporeal Therapies 3. Plasmapheresis: Current Indications in the Critically Ill 4. Are Super High-Flux Membrane Dialyzers the Future of RRT? 5. What is New in Artificial Liver Support Systems? SECTION 3: Sepsis 6. Back to the Genes: Does Genetic Polymorphism have a Role in Sepsis Management? 7. Controversies in Surviving Sepsis Guidelines 2021 8. Are We Back to Square One? Early Fluids vs. Vasopreressors in Septic Shock 9. Have We Achieved Balance in Fluid Therapy: Balanced Salt Solutions vs. Normal Saline? SECTION 4: Biomarkers 10. Novel Biomarkers During Circulatory Shock 11. Biomarkers in Acute Intoxications 12. Do Biomarkers have a Role in Patients with Primary Brain Injury? 13. Utility of MicroRNAs in the Critically Ill 14. Neutrophil to Lymphocyte Ratio in Critically Ill: A Simple but Useful Marker? 15. Do Vocal Biomarkers have a Future in Critical Care SECTION 5: COVID-19 Pandemic: Lessons Learnt 16. Awake Prone Positioning in ARDS? 17. Immunomodulators for COVID-19 Therapy 18. Has Critical Care Telemedicine Come of Age During the Pandemic 19. Post-COVID Conditions (PCCs) or Long COVID Syndrome 20. Capacity Building During Large Scale Disasters 21. Clearing the Air: Alternatives to Isolation Rooms SECTION 6: Mechanical Ventilation 22. Revisiting Exogenous Surfactant Therapy in Acute Lung Injury and ARDS 23. Mechanical Power 24. Volumetric Capnography in 2022 25. Metabolic Alkalosis in Critical Care: A Classical and Physicochemical Approach 26. Oxygen Revisited SECTION 7 28. High-flow Nasal Cannula: Beyond a COVID-19 Therapy 29. Cefiderocol 30. Newer Fluoroquinolones: Levonadifloxacin, Delafloxacin and Lascufloxacin 31. Newer Combinations of B-Lactam/B-Lactamase 32. Newer Tetracyclines — Eravacycline and Omadacycline 33. Plazomicin: A New Aminoglycoside 34. Lefamulin: A Pleuromutilin Antibiotic 35. Pretomanid for Antitubercular Therapy 36. Contezolid Acefosamil: A New Oxazolidinone 37. Solithromycin and Nafithromycin: The New Macrolides 38. Benapenem and Sulopenem 39. The Dsb (Disulfide bond) 40. Antivirulence Strategies: The Future of Antibacterial Therapy 41. Alternatives to Conventional Antibacterials: Use of Nanomaterials 42. Newer Treatment Approach to Clostridioides Difficile – Fidaxomicin and Bezlotoxumab 43. Recent Advances for Immunotherapies Against Infectious Disease SECTION 8: What's New Elsewhere? 44. Risk Scoring Systems in Upper Gastrointestinal Bleed 45. Has Hypotension Prediction Index Come of Age 46. Postintensive Care Syndrome and Postintensive Care Syndrome-Family 47. Closed-Loop Hemodynamic Resuscitation In Shock 48. Is Electrical Impedance Tomography Finally Here to Stay 49. Cardiac Output Measurement: Capnodynamic Method and Auto VTI Tool 50. What’s New in Glucose Management Technologies for the Critically-ill 51. Vitamins and Trace Element Supplementation for Critically Ill Patients in 2022 Index
£27.55
Jaypee Brothers Medical Publishers A Comprehensive Handbook of IVF
Book SynopsisIn vitro fertilisation (IVF) is one of several techniques available to help people with fertility problems have a baby. During IVF, an egg is removed from the woman''s ovaries and fertilised with sperm in a laboratory. The fertilised egg, called an embryo, is then returned to the woman''s womb to grow and develop.This book is a complete guide to IVF for specialists and trainees in reproductive medicine.Divided into two parts, the first sections discuss clinical aspects of IVF, including laboratory set-up, patient selection and preparation, drugs and stimulation protocols, male infertility, the operating theatre and assisted reproductive technology (ART) techniques, special situations such as endometriosis and recurrent implantation failure; and recent advances in ART.The second part of the book covers laboratory aspects, explaining the physical and practical processes of IVF including management of culture conditions, quality control, male and female gametes, embryo gradation and implantation, cryopreservation and sperm freezing, and advanced embryology.With a recognised, international team of authors, this comprehensive text is further enhanced by diagrams and figures to assist learning. Table of ContentsPART A: IVF CLINICAL ASPECTS SECTION 1: STEPPING UP IN IN VITRO FERTILIZATION SECTION 2: DRUGS AND STIMULATION PROTOCOLS IN IN VITRO FERTILIZATION SECTION 3: MALE INFERTILITY SECTION 4: IN VITRO FERTILIZATION OPERATION THEATER AND TECHNIQUES IN ASSISTED REPRODUCTIVE TECHNOLOGY SECTION 5: SPECIAL SITUATIONS IN IN VITRO FERTILIZATION SECTION 6: LET'S LEARN SOMETHING DIFFERENT PART B: IVF LABORATORY ASPECTS (HANDS ON EMBRYOLOGY) SECTION 7 BUILDING UP THE CULTURE AMBIENCE SECTION 8 KNOW YOUR CULTURE CONDITIONS SECTION 9 HANDLING THE MALE GAMETE SECTION 10 THE BOSS: FEMALE GAMETE SECTION 11 OOCYTE/EMBRYO GRADATION SYSTEMS SECTION 12 OOCYTE, EMBRYO, AND IMPLANTATION SECTION 13 FROZEN LIFE SECTION 14 ADVANCED TECHNIQUES: EMBRYOLOGY ADD-ONS SECTION 15 THE EMBRYOLOGIST
£59.85
Jaypee Brothers Medical Publishers Aravind FAQs in Ophthalmology
Book SynopsisThis book is a compilation of frequently asked questions (FAQs) with answers to help students prepare for postgraduate ophthalmology examinations. The third edition, comprising more than 1200 pages, has been fully revised to provide students with the latest information and advances in the field. Answers to questions have been meticulously refined in line with current concepts and knowledge. Divided into fourteen sections, the book begins with an introduction, followed by numerous questions for each part of the eye. As well as exam-oriented questions, the text also features a management summary of commonly kept examination cases and examples of case sheet writing. The final section provides an ophthalmology question bank to assist students with revision and test their understanding. The previous edition (9789386261090) published in 2018.Table of Contents Introduction Cornea Uvea Glaucoma Lens and Cataract Retina Neuro-ophthalmology Orbit Pediatric Ophthalmology and Strabismus Optics and Refraction Miscellaneous Management Summary of Commonly Kept Examination Cases Case Sheet Writing Ophthalmology Question Bank Index
£31.35
Jaypee Brothers Medical Publishers Tips Tricks in Interventional Cardiology
Book SynopsisThis new edition has been fully revised to provide clinicians with the latest advances in interventional cardiology, focusing on key procedures used in practice. Beginning with an overview of percutaneous coronary intervention (PCI), the following sections discuss imaging techniques (IVUS and OCT), instruments such as stents, and techniques for different cardiovascular disorders. A complete chapter is dedicated to drugs used in the catheterisation lab and mechanical circulatory support. The book concludes with discussion on structural and congenital heart disease, and complications of PCI. The third edition has been expanded and includes new topics and features numerous clinical photographs, diagrams and tables. The previous edition (9789352700875) published in 2017.
£36.10
Jaypee Brothers Medical Publishers Retina Atlas
Book SynopsisThis atlas provides ophthalmologists with a collection of images to help with the identification, diagnosis and subsequent treatment of retinal disorders.The images are procured from Eidon scanner technology and also include optical coherence tomography (OCT) pictures to assist with understanding of related pathologies.Divided into nine sections, the book begins with images illustrating the normal fundus. Each of the following sections covers a different retinal disorder including diabetic retinopathy, macula disorders, retinal detachment, ocular tumours and hereditary diseases.Each section features a multitude of images, each with brief descriptive text to assist understanding.The second edition of this illustrative atlas has been fully revised and updated to reflect the latest developments and knowledge in the field.Previous edition (97893895874432) published in 2020.
£80.75
Jaypee Brothers Medical Publishers Hypertension
Book SynopsisHypertensionis another name for high blood pressure. It can lead to severe complications and increases the risk of heart disease, stroke, and death. Blood pressure is the force exerted by the blood against the walls of the blood vessels. This book is a comprehensive guide to the diagnosis and management of high blood pressure. Divided into three sections, the text begins with an overview of the condition, current guidelines on its management, potential organ damage, and nonpharmacological treatments. The next section covers the management of hypertension with associated disorders such as diabetes, cardiovascular disease, stroke, kidney disease, and more. A complete chapter is dedicated to white coat' hypertension. The final section discusses management approaches when initial treatment fails, and hypertensive emergencies. Each chapter is presented as a case scenario, describing prevention, diagnosis, previous control attempts, challenges, and treatments, both pharmalogical and nonpharmalogical. This second edition has been fully revised and updated to provide clinicians and trainees with the latest advances and knowledge in the field. A number of new topics have also been included. Authored by experts from the University of South Carolina, the text is further enhanced by clinical images, figures and tables. The previous edition (9789386261489) published in 2019.
£69.21
Jaypee Brothers Medical Publishers Color Atlas of Cornea
Book Synopsis
£71.25
Jaypee Brothers Medical Publishers Rapid ECG Interpretation
Book SynopsisThe practical substance of this text is aimed at all doctors who assess, and prescribe for patients with cardiovascular problems. It is for clinicians and residents who wish to interpret ECGs accurately. The arrhythmia chapter is packed with clues for diagnosis and therapy, and practical steps. Presents a unique 11-step method for accurate and rapid ECG interpretations in a user-friendly synopsis format. It is thoroughly revised and updated. Includes the latest updates of ECG interpretation along with its importance in assessments of various abnormalities such as ST-segment elevation and also an addition of chapter on enhancing ECG quality. Provides different diagnostic ECG criteria with relevant and instructive ECGs that act as ready-reckoner for proficiency tests and also helpful for physicians who are preparing for the Cardiovascular Diseases Board Examination. The significant information are presented through a succinct writing style and highlighted with bullets. The practical aspects of the book help the clinicians and senior residents for accurate interpretations of the ECG associated with cardiovascular diseases. Table of Contents1Electrocardiogram Basic Concepts must be Mastered 2New Method for ECG Interpretation 3P Wave Abnormalities 4Bundle Branch Block 5ST Segment Abnormalities, ST segment elevation MI, non ST segment elevation MI 6Q Wave Abnormalities 7Atrial and Ventricular Hypertrophy 8T Wave Abnormalities 9Electrical Axis and Fascicular Blocks 10Miscellaneous Conditions 11Arrhythmias 12ECG Board Self-Assessment Quiz 13New placements of limb lead provide superior quality ECG s.
£32.00
Springer Common Bile Duct Exploration: Intraoperative investigations in biliary tract surgery
Book Synopsis2. Stone extraction via the T-tube 89 3. Endoscopic method 89 4. Preparation for stone extraction 90 5. Technique 90 6. Results 91 7. Complications 91 8. Discussion 91 Index of Subjects 99 CHAPTER 1 INTRODUCTION This book was conceived as a descriptive atlas of most reliable indication for common bile duct ex routine biliary surgery i. e. , cholecystectomy and ploration. The cholangioscope allows a visual ex exploration of the common bile duct. For the pro ploration of the biliary tree and permits the re ject the two authors worked together for one week moval of common bile duct calculi and other as biopsy under direct visual con at Ninewells Hospital and Medical School, Dundee procedures such on a series of patients with biliary tract disease trol. Both procedures have been described in detail especially selected for the exercise. With the con with emphasis on the practical aspects of their use. sent of the Tayside Health Board and the patients The era of blind bilary surgery is over and the concerned, all the operations and peri-operative sooner this message is received by all concerned, procedures were filmed by the photographic mem the better the outcome of biliary surgical practice bers of the team, Mr. and Mrs. Paz-Partlow. Ad overall. ditional case material has been obtained from It has not been our intention to produce a com Cedars Sinai Medical Center, Los Angeles.Trade Review`...excellently illustrated... ...of value to all surgeons performing biliary tract surgery.' Gastrointestinal Endoscopy, 31:5 (1985) `...an easy to read and excellent cooperative project from Scotland and the USA between a surgeon, endoscopist and radiologist. It can be commended to abdominal surgeons and will make a useful contribution to safer cholecystectomy.' Journal of the Royal Society of Medicine, 78 (1985) `...should be of help to all surgeons in training.' British Medical Journal, 219 (1985) Table of Contents1. Introduction.- 2. Review of existing problems in biliary tract surgery.- 3. Surgical approach and principles.- 1. Introduction.- 2. Prophylactic measures.- 2.1. Infectious complications.- 2.2. Haemorrhagic complications.- 2.3. Renal failure.- 3. Pre-operative biliary decompression in the jaundiced patient.- 4. Operative principles.- 4.1. Surgical access.- 4.2. Patient positioning.- 4.3. Appropriate incision.- 4.4. Illumination of the operating field.- 4.5. Packing.- 4.6. Exposure of relevant anatomy.- 5. Drainage of the supracolic compartment after biliary operations.- 4. Operative cholangiography (in cooperation with J.A. Hamlin and M. Paz-Partlow).- 1. Introduction.- 2. Common bile duct explorations.- 3. Unsuspected stones.- 4. Cannulation techniques.- 5. Initial and/or completion cholangiograms.- 6. Standard technique.- 6.1. Technique and equipment.- 6.2. Patient’s positioning.- 6.3. Scout film.- 6.4. Injected volume.- 6.5. Contrast material.- 6.6. Coordination of exposure.- 6.7. Mobile C-arm fluoroscope.- 7. Fluoro-cholangiography.- 7.1. Easy positioning of the patient.- 7.2. Optimal beam collimation.- 7.3. Shorter exposure time.- 7.4. Automatic exposure control.- 7.5. Minimal technician activity.- 7.6. Control of the exposure sequence.- 7.7. Serial films.- 7.8. Decreased examination time.- 7.9. Indirect radiography.- 8. Anomalies of surgical importance.- 8.1. Short cystic duct.- 8.2. Drainage of cystic duct in the right hepatic duct.- 8.3. Aberrant ducts.- 8.4. Ductal diverticula and choledochocele.- 8.5. The acute or emergency case.- 9. General aspects.- 10. Radiation protection.- 11. The cystic duct.- 12. Cholecysto-cholangiogram.- 13. The choledocho-cholangiogram.- 13.1. Direct needle puncture.- 13.2. Butterfly needle puncture.- 13.3. Special needle clamp.- 13.4. T-tube insertion.- 14. Contact selective cholangiography.- 15. Reason for failure for operative cholangiography.- 15.1. Overfilled ducts.- 15.2. Underfilled ducts.- 15.3. Poor quality films.- 15.4. Improper positioning.- 15.5. Obscured field.- 16. Artifacts.- 17. Complications of operative cholangiography.- 18. Reformed calculi.- 19. Complications of T-tube removal in the post-operative period.- 20. Results of operative cholangiography.- 20.1. Advantages.- 20.2. Disadvantages.- 5. Operative biliary endoscopy (cholangioscopy) (in cooperation with M. Paz-Partlow).- 1. Introduction.- 2. Instrumentation.- 2.1. Accessories.- 3. Technique.- 3.1. Mobilization of the duodenum.- 3.2. Endoscopic appearance.- 3.3. The cystic stump remnant.- 4. Endoscopic anatomy and pathology.- 4.1. Normal findings.- 4.2. Cholangitis.- 4.3. Calculi.- 4.4. Ampullary stenosis.- 4.5. Neoplasms.- 4.6. Miscellaneous.- 5. Repeated cholangioscopy.- 6. Complications.- 7. General aspects.- 7.1. Sterilization.- 7.2. Maintenance.- 8. Evaluation of results.- 9. Conclusions.- 6. Biliary manometry and debimetry.- 1. Introduction.- 2. Usage.- 3. Pharmacolgy of the sphincter of Oddi (SO).- 3.1. Effect of hormones and peptides.- 3.2. Effect of pharmacological agents.- 4. Biliary pressure indices.- 4.1. Resting (initial, interdigestive) pressure.- 4.2. Passage (yield, opening) pressure.- 4.3. Filling pressure curves.- 4.4. Residual pressure.- 4.5. Flow rate (debimetry).- 4.6. Incremental pressure and recovery time.- 5. Dynamic (transducer) manometry.- 5.1. Endoscopic sphincter zone activity.- 5.2. Technique of operative biliary manometry.- 6. Disorders of the sphincter of Oddi.- 6.1. Iatrogenic stricture.- 6.2. Papillitis/Oedema.- 6.3. Papillary stenosis (choledocho-duodenal junctional stenosis).- 6.4. Functional disorders.- 7. Exploration of the common bile duct.- 1. Introduction.- 2. Technique of CBD exploration.- 2.1. Mobilization of duodenum and head of pancreas.- 2.2. Exposure of the CBD.- 2.3. Choledochotomy.- 2.4. Cholangioscopy.- 2.5. Additional procedures.- 2.6. Insertion of T-tube.- 2.7. Closure of choledochotomy wound.- 3. Trans-duodenal exploration od CBD.- 4. Intra-hepatic calculi.- 5. Assessment of terminal end of the CBD and sphincteric region.- 6. Post-operative removal of T-tube.- 7. Conclusion.- 8. Postoperative removal of retained stones through the T-Tube tract (in cooperation with J.A. Hamlin).- 1. Introduction.- 2. Stone extraction via the T-tube.- 3. Endoscopic method.- 4. Preparation for stone extraction.- 5. Technique.- 6. Results.- 7. Complications.- 8. Discussion.- Index of Subjects.
£40.49
Springer Transport and Inherited Disease: Monograph based upon Proceedings of the Seventeenth Symposium of The Society for the Study of Inborn Errors of Metabolism
Book SynopsisMany clinical problems of transport have been known for decades, par ticularly those disorders involving the liver and kidney. As a result of the dramatic increase in interest in transport at the membrane level the Society devoted its Seventeenth Symposium, held at Leeds during September 1979, to Transport and Inherited Disease, the result of that meeting forming the basis of this monograph. For the occasion over a hundred members and guests of the Society were joined by many invited speakers from Europe and the USA to discuss this rapidly developing field with special reference to the direct interests of the Society - in herited metabolic disease. The major theme of the meeting was opened with formal scientific presentations on membrane structure, synthesis and the regulation of epithelial transport. These were followed by discussions of specific prob lems of transport in brain, kidney and red blood cells. Almost all of these later lectures had clinical applications with cystic fibrosis and nephro genic diabetes insipidus featuring as examples of the common inherited diseases. The Hudson Memorial Lecture was delivered by Professor H. Bickel (Heidelberg). This outstanding review lecture on 'Phenylketonuri- past, present and future' is reproduced in the Journal of the Society - the Journal of Inherited Metabolic Disease (Volume 3 No.4, pp.123-132). xiii xiv PREFACE The members' papers (both oral and poster) are also being reprinted in various issues of the Journal (published by MTP Press Ltd., Lancaster, UK).Table of ContentsSection One.- 1 The inherited methylmalonic acidaemias: a model system for the study of vitamin metabolism and apoenzyme-coenzyme Interactions — The Milner Lecture.- Section Two Biochemistry of Membranes.- 2 Membrane structure.- 3 Synthesis of membranes.- 4 Some regulatory principles in epithelial transport.- Section Three Transport in Brain.- 5 The needs of the brain for amino acids and how they are transported across the blood-brain barrier.- 6 Some aspects of the transport of glucose and ketone bodies into the brain and retina.- Section Four Renal Transport.- 7 The function and organization of kidney microvillar proteins.- 8 Cyclic nucleotides and the regulation of water and electrolyte transport.- 9 Mineralocorticoids and sodium transport.- 10 Sodium transport in cystic fibrosis.- 11 Nephrogenic diabetes insipidus.- 12 Mendelian hypophosphataemias as probes of phosphate and sulphate transport by mammalian kidney (X-linked hypophosphataemia. Autosomal hypophosphataemia in man and Hyp mutation in mouse).- 13 Renal transport of cystine by isolated renal tubules and brush-border membrane vesicles.- 14 5-Oxoprolinuria and other inborn errors related to the ?-glutamyl cycle.- Section Five Transport in Red Blood Cells.- 15 Anion transport in red blood cells.- 16 Inherited disorders of red-cell cation transport.- 17 Red-cell amino acid and nucleoside transport: inherited lesions and related enzyme deficiencies in sheep.
£40.49
Springer Inborn Errors of Metabolism in Humans: Monograph based upon Proceedings of the International Symposium held in Interlaken, Switzerland, September 2–5, 1980
Table of ContentsSection One Pathogenic Mechanisms of Inborn Errors: Clinical Implications of Biochemical Diversity.- 1 Molecular aspects of genetic heterogeneity.- 2 Inborn errors of purine metabolism-The Milner Lecture.- 3 Vitamin-responsive inherited metabolic disorders: propionic acidaemia and methylmalonic acidaemia.- 4 Homocystinuria: clinical and biochemical heterogeneity.- 5 Hereditary defects of steroid biosynthesis.- 6 Blood-brain barrier amino-acid transport: clinical implications.- Section Two Treatment: New Aspects and Limits, Transplantation, Replacement Therapy, Genetic Engineering.- 7 Recent studies on the maturation of lysosomal enzymes.- 8 Enzyme substitution by fibroblast transplantation.- 9 Artificial cell-encapsulated enzymes and adsorbents in congenital metabolic disorders.- 10 Prospects for enzyme replacement therapy in heritable metabolic disorders.- Section Three Inborn Errors of Metabolism affecting Brain Development (Animal Models).- 11 Inborn errors of metabolism affecting brain development-Introduction.- 12 Mutations in mice affecting brain development and their correlations with human diseases.- 13 Murine mutations affecting myelination: models to study myelin diseases in the human.- 14 The effect of phenylalanine on myelin metabolism in adolescent rats.- 15 Abnormal oligodendrocyte differentiation in a mouse mutant with defect in myelination.- Section Four Consequences of Inborn Errors of Metabolism for the Individual, the Family and Society.- 16 Inborn errors of metabolism consequences of long-term treatment for the individual, as derived from observations in phenylketonuria.- 17 Social aspects of the handicapped person.- 18 Psychological and educational aspects of handicap.- 19 Repercussions of screening.- 20 Some principles in the management of inherited metabolic disease.
£40.49
Springer Problems in Arthritis and Rheumatism
Book SynopsisThis series of books is designed to help general practitioners. So are other books. What is unusual in this instance is their collec tive authorship; they are written by specialists working at district general hospitals. The writers derive their own experi ence from a range of cases less highly selected than those on which textbooks are traditionally based. They are also in a good position to pick out topics which they see creating difficulties for the practitioners of their district, whose personal capacities are familiar to them; and to concentrate on contexts where mistakes are most likely to occur. They are all well-accustomed to working in consultation. All the authors write from hospital experience and from the viewpoint of their specialty. There are, therefore, matters important to family practice which should be sought not within this series, but elsewhere. Within the series much practical and useful advice is to be found with which the general practitioner can compare his existing performance and build in new ideas and improved techniques. These books are attractively produced and I recommend them.Table of ContentsSection 1 General Aspects.- 1 Introduction.- Importance of rheumatology in practice.- Classification of rheumatic disorders.- Frequency of rheumatic disorders in family practice.- The outcome and prognosis of rheumatic diseases.- 2 Some illustrative problems.- Ankylosing spondylitis.- Non-steroidal anti-inflammatory drugs.- Pain and paraesthesiae in arms.- The acute back.- The painful foot.- A gouty attack.- The painful hip.- A knee effusion.- Laboratory investigations.- The acute neck.- Helpful organizations.- Polymyalgia rheumatic.- Early rheumatoid arthritis.- The painful shoulder.- Tennis elbow.- 3 Diagnosis and assessment of rheumatic disorders.- Symptoms, signs and their diagnostic significance.- X-rays and laboratory investigations.- Early diagnosis: indications for referral for further opinion.- 4 Effect of the psyche on rheumatism.- Assessment of the ‘psychological overlay’.- Psychological and emotional disturbance: their manifestations in rheumatology.- pure — psychogenic rheumatism.- 5 Basic management of arthritis and rheumatism.- Pain relief.- Disease activity and its reduction.- Improvement of mobility and function.- Analgesics.- Anti-inflammatory drugs.- Practical procedures in family practice.- Physiotherapy.- Occupational therapy and rehabilitation.- Section 2 The Common Rheumatic Disorders.- 6 Soft-tissue (non-articular) rheumatism.- Classification.- Clinical varieties and treatment.- 7 Osteoarthritis.- Aetiology and pathology.- Clinical varieties.- Management in family practice.- Management in hospital.- 8 Rheumatoid arthritis.- Early recognition.- Complications.- Differential diagnosis.- Management of the early case in practice.- Hospital management.- Rheumatoid arthritis in children and the elderly.- 9 Ankylosing spondylitis and seronegative spondarthritis.- Concept of seronegative spondarthritis.- Ankylosing spondylitis.- Clinical features.- Management in practice.- 10 Gout and crystal deposition arthritis.- Crystal deposition arthritis: clinical varieties.- Gout: investigation of patients.- Treatment of gout.- Investigation and treatment of chondrocalcinosis.- Section 3 Regional Pain Syndromes.- 11 Pain in the neck and back.- Common causes of pain.- Investigation of neck pain syndromes.- Treatment of neck pain syndromes.- Investigation of low back pain.- Treatment of low back pain.- 12 Pain syndromes of the upper limb.- Causes of pain.- Diagnosis and treatment of pain.- 13 Pain syndromes of the lower limb.- Causes of pain.- Diagnosis and treatment of pain.- Causes of painful feet.- Section 4 Appendix.- Glossary of rheumatic disorders.- Further reading.
£44.99
Springer Basic and Clinical Hepatology
Book SynopsisThe liver has been an organ of mystery for centuries. Slowly but surely its secrets have been disclosed by both basic research and clinically oriented investigators whose current concepts have been brought together in this book by authors from five different countries. Three major groups with many subgroups have made inroads into our better understanding of the liver. The first of these comprises the basic scientists whose study of single hepatocytes may provide the key to comprehension of mechanisms that will lead eventually to improvement in the morbidity and mortality associated with a variety of hepatic disorders. The second group has been concerned with studies in depth of the liver's response to a variety of hormones, drugs, viruses, and infections. Both early and late results are their concern in the diagnosis and treatment of the individual patient. A third group comprises the surgeons who have become increasingly aggressive in the removal of one or more segments of the liver. They have increased the scope of hepatic resection as a result of a better understanding gained from studies of various segments of the liver. They have accepted the term, segmentectomy, and have extended feasible procedures to include trisegmentectomy. Indeed, trans plantation of the liver has been successfully accomplished.Table of Contents1. Segments of the liver: the anatomical basis for partial hepatectomy.- 2. Fine structure of human liver cells.- 3. Scanning electron microscopy of the mammalian liver.- 4. Freeze-fracture of hepatic fine structure under normal and experimental conditions.- 5. Morphofunctional features of cultured liver cells.- 6. Microcirculation of the liver, with special reference to the peribiliary portal system.- 7. Liver stereology.- 8. Liver physiology and biochemistry.- 9. Electron microscopy in human liver pathology.- 10. Radiology of the liver.- 11. Clinical aspects of modern hepatology.- 12. Trends and developments in hepatic surgery.
£40.49
Springer Inherited Disorders of Carbohydrate Metabolism: Monograph based upon Proceedings of the Sixteenth Symposium of The Society for the Study of Inborn Errors of Metabolism
Book SynopsisThe sixteenth annual symposium of the Society for the Study of Inborn Errors of Metabolism was held in Bristol from 12th to 14th July, 1978. About 25 invited speakers and 150 participants came from many parts of Europe and North America to consider the topic, 'Inherited Disorders of Carbohydrate Metabolism'. Although some aspects of these disorders have formed part of the programme of previous symposia organized by the Socie ty, this was the first attempt to discuss them in a systematic manner. The subject, carbohydrate disorders, embraces both familiar and well documented conditions and some lesser known aspects of genetic disease. In all of these there remains much to be learnt about clinical and laboratory diagnosis, treatment, biochemical screening and pathogenesis. Thus one aim of the Society, to combine clinical and scientific interest, can rarely have been better achieved in a single symposium. Since the programme included diseases from six different areas of car bohydrate metabolism and contained so many distinguished speakers, it is impossible to highlight the more important aspects of this symposium within a short space. Each section made a notable contribution to knowledge and, when time was available, lively discussions ensued which have been recorded in the book. However, we wish to mention our two special lectures, because they recognise people to whom the Society owes a great deal. The Milner lecture has been given for the past 6 years as a tribute to Mr J.Table of ContentsSection One Introduction.- 1 Carbohydrate metabolism and its regulation — The Milner Lecture.- Section Two Disorders of Carbohydrate Absorption.- 2 Basic causes of carbohydrate malabsorption.- 3 Clinical aspects of disordered carbohydrate absorption.- Section Three Disorders of Galactose Metabolism.- 4 Galactose metabolism, hereditary defects and their clinical significance.- 5 Clinical aspects of Galactosaemia.- 6 How long should galactosaemia be treated?.- 7 Pregnancy in classical galactosaemia.- 8 Screening for galactosaemia.- 9 Prenatal diagnosis of classical galactosaemia.- 10 Discussion.- Section Four Disorders of Fructose Metabolism.- 11 Clinical and genetic studies of disorders in fructose metabolism.- 12 Pathogenic mechanisms of disorders in fructose metabolism.- 13 Discussion.- Section Five Disorders of Pyruvate Metabolism.- 14 Pathways and regulation of pyruvate metabolism.- 15 Pyruvate dehydrogenase deficiencies.- 16 Pyruvate carboxylase deficiency, studies on patients and on an animal model system.- Section Six Glycogen Storage Diseases.- 17 Recent advances and problems in the glycogen storage diseases.- 18 Hepatic glycogenosis: diagnosis and management — The F. P. Hudson Memorial Lecture.- 19 Recent work on treatment of Type I glycogen storage disease.- 20 Pre- and postnatal diagnosis of glycogen storage disease.- 21 Type VI glycogenosis: identification of subgroups.- 22 Discussion.- Section Seven Genetic Aspects of Diabetes.- 23 Clinical studies of the inheritance of diabetes mellitus.- 24 HLA antigens and diabetes.- 25 Juvenile diabetes and optic atrophy.- 26 Discussion.
£44.99
Springer Diabetes and Atherosclerosis
Book Synopsis1. Atherosclerosis.- 2. Gastrointestinal Regulatory Peptide Control of Insulin Secretion and its Relevance to Diabetes Mellitus.- 3. Insulin Resistance.- 4. Diabetes Mellitus and Atherosclerosis.- 5. Risk Factors for Atherosclerosis in Diabetes Mellitus.- 6. Lipid Metabolism and its Disorders in Diabetes Mellitus.- 7. Diabetes Mellitus and Raised Blood Pressure.- 8. Insulin and Atherosclerosis.- 9. The Possible Role of Glycation in the Pathogenesis of Atherosclerosis.- 10. Haemostatic Disorders in Diabetes Mellitus.- 11. Proteinuria in Relation to Cardiovascular Mortality and Morbidity in Diabetes Mellitus.- 12. Non-ischaemic Heart Disease in Diabetes Mellitus.- 13. Experimental Atherosclerosis and Diabetes Mellitus.Trade Review' This book is of interest to clinicians of different specialties participating in the management of diabetic patients, but it is also good reference source for researchers in this field. ' Journal of the Royal Col. of Phy. of London 26:4 1992 '....but I can thoroughly recommend it to cardiologists, diabetologists, endocrinologists, general physicians, geriatricians, pathologists and vascular surgeons.' Age and Ageing 22:1 1993 'I will find the book a useful source. I recommend the book to those who are interested in the all too common problem that it is atherosclerosis that most commonly leads to the clinical morbidity and early death of our diabetic patients.' The Ulster Medical Journal 61:1 1992 Table of Contents1. Atherosclerosis.- 2. Gastrointestinal Regulatory Peptide Control of Insulin Secretion and its Relevance to Diabetes Mellitus.- 3. Insulin Resistance.- 4. Diabetes Mellitus and Atherosclerosis.- 5. Risk Factors for Atherosclerosis in Diabetes Mellitus.- 6. Lipid Metabolism and its Disorders in Diabetes Mellitus.- 7. Diabetes Mellitus and Raised Blood Pressure.- 8. Insulin and Atherosclerosis.- 9. The Possible Role of Glycation in the Pathogenesis of Atherosclerosis.- 10. Haemostatic Disorders in Diabetes Mellitus.- 11. Proteinuria in Relation to Cardiovascular Mortality and Morbidity in Diabetes Mellitus.- 12. Non-ischaemic Heart Disease in Diabetes Mellitus.- 13. Experimental Atherosclerosis and Diabetes Mellitus.
£170.99
Springer Peritoneal Dialysis: Third edition
Book SynopsisPeritoneal dialysis represents an internal technique for membrane are becoming apparent. Studies of peritoneal blood purification. In this dialyzer the blood path, the dialysis increase understanding of the anatomy and phy membrane and the dialysate compartment are provided by siology of biological membranes and the factors influencing nature. The developments of chronic peritoneal catheters, the passive movement of solutes across the microcirculation and related structures. Peritoneal dialysis provides a 'win automated cycling equipment, solution preparation by reversed osmosis, manipulations of transport with drugs dow' to the visceral microcirculation in animals and hu and the experiences with continuous ambulatory peritoneal mans. dialysis and continuous cycling peritoneal dialysis have Peritoneal dialysis may be useful to treat problems other increased the interest in peritoneal dialysis. Publications than renal failure. Beneficial effects in the treatment of related to peritoneal dialysis probably exceed 400 annually. dysproteinemias, psoriasis, hypothermia, and many meta Peritoneal Dialysis International (formally Peritoneal Dialy bolic problems have been reported. The intraperitoneal sis Bulletin) the official journal of the International Society administration of chemotherapeutic agents draws upon and for Peritoneal Dialysis is a journal solely devoted to contributes to our understanding of peritoneal dialysis.Trade Review`This book can be recommended to any nephrologist with a strong interest in peritoneal dialysis.' R. Gutman, Dialysis and Transplantation, February 1990Table of Contents1. History of peritoneal dialysis.- 2. The peritoneal dialysis system.- 3. Role of the peritoneal microcirculation in peritoneal dialysis.- 4. Peritoneal cavity lymphatics.- 5. Peritoneal ultrastructure.- 6. Transport kinetics.- 7. Ultrafiltration with peritoneal dialysis.- 8. New approaches to intermittent peritoneal dialysis therapies.- 9. Continuous ambulatory peritoneal dialysis.- 10. Continuous cyclic peritoneal dialysis.- 11. Pharmacologic alteration of peritoneal transport rates.- 12. Comments on dialysis solution, antibiotic transport, poisonings, and novel uses of peritoneal dialysis.- 13. Nutritional management of patients undergoing peritoneal dialysis.- 14. Peritonitis.- 15. Complications other than peritonitis or those related to the catheter and the fate of uremic organ dysfunction in patients receiving peritoneal dialysis.- 16. Peritoneal dialysis access.- 17. Peritoneal dialysis in children.- 18. Peritoneal dialysis in diabetics.- 19. The stability and kinetics of peritoneal mass transfer.- 20. The USA CAPD registry. Characteristics of participants and selected outcome measures for the period January 1, 1981, through August 31, 1987.- 21. Peritoneal dialysis results in the EDTA registry.- 22. Quality of life in peritoneal dialysis patients: instruments and application.- Index of subjects.
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£40.49
Springer Practical Developments in Inherited Metabolic Disease: DNA Analysis, Phenylketonuria and Screening for Congenital Adrenal Hyperplasia: Proceedings of the 23rd Annual Symposium of the SSIEM, Liverpool, September 1985
Table of ContentsThe 23rd Annual Symposium of the SSIEM: Liverpool.- to recombinant DNA.- Human biochemical genetics of enzyme proteins in the new age of molecular genetics.- Direct DNA analysis in family studies.- Application and limitations of direct DNA analysis in genetic prediction.- DNA analysis for ornithine transcarbamylase deficiency.- Molecular genetics of PKU.- Human DNA repair defects.- Molecular basis of ai-antitrypsin deficiency and its potential therapy by gene transfer.- Direct alteration of a gene in the human genome.- Diabetes mellitus, atherosclerosis, and the 5’ flanking polymorphism of the human insulin gene.- Workshop on Screening for Congenital Adrenal Hyperplasia (steroid 21-hydroxylase deficiency).- Clinical aspects of congenital adrenal hyperplasia: early diagnosis and prognosis.- Biochemical aspects of congenital adrenal hyperplasia.- Large-Scale Pilot Studies.- Review of CAH screening programmes and the Scottish experience.- Neonatal screening programme for congenital adrenal hyperplasia in a homogenous Caucasian population.- Neonatal screening for congenital adrenal hyperplasia: a pilot study in France.- Existing Clinical Diagnoses.- Congenital adrenal hyperplasia in Birmingham: a retrospective analysis (1958-1985).- Prevalence of adrenal 21-hydroxylase deficiency in neonates born in the West Midlands: a retrospective study.- Clinical Symposium - Phenylketonuria.- and explanation.- Maternal phenylketonuria.- Dietary problems of phenylketonuria: effect on CNS transmitters and their possible role in behaviour and neuropsychological function.- Diagnosis in relationship to treatment of hyperphenylalaninaemia.- Problems related to diet management of maternal phenylketonuria.- Short Communications.- Preface and Free Communications.- Molecular biology of phenylalanine hydroxylase.- Hepatic phenylalanine hydroxylase and dietary tolerance in hyperphenylalaninaemic patients.- Phenylalanine metabolites in treated phenylketonuric children.- Magnesium-deficient rickets in a phenylketonuric patient on dietary treatment.- Termination of strict diet in phenylketonuria: neurophysiological, psychological and biochemical studies.- Effects of stopping phenylalanine-restricted diet on intellectual progress of children with phenylketonuria.- Maternal hyperphenylalaninaemia: dietary treatment during pregnancy.- Maternal hyperphenylalaninaemia in Israel.- Maternal phenylketonuria with increased tyrosine supplements.- Screening for phenylketonuria in Yugoslavia (SR Croatia) 1979–1984.- Incidence of phenylketonuria and hyperphenylalaninaemia in a sample of the Turkish newborn population.- Atypical phenylketonuria with mild mental retardation caused by tetrahydrobiopterin deficiency in a Chinese family.- Dihydropteridine reductase deficiency: clinical, biochemical and therapeutic aspects.- Partial dihydropteridine reductase deficiency and mental retardation.- Urine amino acid analysis by HPLC in the investigation of inborn errors of metabolism.- Plasma amino acid patterns in critically ill children.- Treatment of hereditary tyrosinaemia (fumarylacetoacetase deficiency) by enzyme substitution.- Presentation of the data of the Italian registry for oculocutaneous tyrosinaemia.- A new case of hyperlysinaemia with saccharopinuria.- Failure of early diazepam treatment in a neonate with non-ketotic hyperglycinaemia.- Gyrate atrophy of the choroid and retina: 3 cases in one Italian family.- Methylenetetrahydrofolate reductase and methyltetrahydrofolate methyltransferase in human fetal tissues and chorionic villi.- Kinetic studies on the glucose-6-phosphate transport system in rat hepatic microsomal membrane.- Long term cornstarch therapy in glycogen storage disease types I, lb and III.- Galactose-l-phosphate-uridyl transferase activity in chorionic villi: a first trimester prenatal diagnosis of galactosaemia.- Molecular heterogeneity of McArdle disease.- Decreased affinity of phosphorylase ? for glucose-1 -phosphate in polymorphonuclear leukocytes of patients with glycogenosis type VI.- The diagnosis and treatment of a patient with medium-chain acyl-CoA dehydrogenase deficiency: overnight fasting does not result in the expected urinary metabolite profile.- A new case of familiar C6-C14 dicarboxylic aciduria with favourable evolution.- Pyruvate carboxylase responsive to ketosis in a multiple carboxylase deficiency patient.- Neonatal screening for biotinidase deficiency: an update.- GM2 gangliosidosis with hexosaminidase A and B defect: report of a family with motor neuron disease-like phenotype.- A comparison between hepatocytes and macrophages of sphingomyelin, cholesterol and acid lipase in various types of Niemann-Pick disease.- Juvenile dystonia without vertical gaze paralysis: Niemann-Pick type C disease.- Pre- and postnatal diagnosis of the cerebro-hepato-renal (Zellweger) syndrome via a simple method directly demonstrating the presence or absence of peroxisomes in cultured skin fibroblasts, amniocytes or chorionic villi fibroblasts.- Impaired cholesterol side chain cleavage activity in liver from patients with cerebro- hepato-renal (Zellweger) syndrome in relation to the accumulation of di- and trihydroxycoprostanoic acid in serum.- Deficiency of dihydroxyacetonephosphate acyltransferase and catalase-containing particles in patients with infantile Refsum’s disease.- Peroxisomal abnormalities in rhizomelic chondrodysplasia punctata.- Cytogenetic studies of three families with ataxia-telangiectasia (Louis-Bar syndrome).
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Springer Organic Acidurias: Proceedings of the 21st Annual Symposium of the SSIEM, Lyon, September 1983 The combined supplements 1 and 2 of Journal of Inherited Metabolic Disease Volume 7 (1984)
Book SynopsisThe first symposium of the Society for the Study ofInborn valuable overview of advances in the application of Errors of Metabolism (SSIEM) on the organic acid urias chemical analysis of amniotic fluid to their early prenatal was held in Leeds in 1971 and published by the Society in diagnosis. The continuing complexity of diagnosis, 1972 (the 9th Annual SSIEM Symposium). Although biochemistry and aetiology ofthe dicarboxylic acid urias relatively few of these disorders were recognized at that has been admirably reduced by the papers from Dr time, the symposium was prompted by the then recent Gregersen and Dr Goodman, with Dr Goodman clearly identification between 1966 and 1970 of isovaleric identifying the primary defect in the polycystic variant of acidaemia, methylmalonic aciduria, propionic aci- multiple acyl CoA dehydrogenase deficiency ("glutaric daemia, pyroglutamic aciduria and 3-methylcrotonyl- aciduria type II") as a deficiency of electron transfer glycinuria. Identification and diagnosis of diseases of this flavoprotein (ETF) dehydrogenase. Dr Engel's paper kind had greatly improved primarily through the also provides a useful overview from currently available application of gas chromatography and mass spectro- data of the place of L-carnitine in the organic acid urias, metry to medicine, although the complexity of the an area in which rapid developments are occurring. The underlying biochemistry and the genetic heterogeneity of emerging understanding of the aetiologies of the the organic acidurias was not then realised.Table of ContentsPreface.- Section I: Clinical aspects: management and outcome.- Neonatal management of organic acidurias. Clinical update (Hudson Memorial Lecture).- Long term outcome of organic acidurias: survey of 105 French cases (1967-1983).- The management and long term outcome of organic acidaemias.- Prenatal diagnosis of the organic acidurias.- Symptoms and signs in organic acidurias.- Section II: Dicarboxylic acidurias and acyl-CoA dehydrogenase deficiencies.- Fatty acyl-CoA dehydrogenase deficiency: enzyme measurement and studies on alternative metabolism.- Glutaric acidaemia type II (multiple acyl-CoA dehydrogenation deficiency).- Carnitine metabolism and inborn errors.- Gas chromatography—mass spectrometry (GC—MS) diagnosis of 2 cases of medium chain acyl-CoA dehydrogenase deficiency.- The differential diagnosis of dicarboxylic aciduria.- Animal models for dicarboxylic aciduria.- Section III: Disorders of the respiratory chain and the lactic acidaemias.- Mitochondrial oxidative phosphorylation and respiratory chain: review.- Mitochondrial myopathies: disorders of the respiratory chain and oxidative phosphorylation.- Lactic acidaemia.- Pyruvate carboxylase deficiency.- Organic acids in urine of patients with congenital lactic acidoses: an aid to differential diagnosis.- Section IV: A new disorder: 4-hydroxybutyric aciduria.- Clinical review.- Biochemical findings.- Enzymology and mode of inheritance.- Section V: Short Communications.- Preface to Short Communications.- Free Communications.- Electron-transferring flavoprotein deficiency in the multiple acyl-CoA dehydrogenation disorders, glutaric aciduria type II and ethylmalonic-adipic aciduria.- Glutaric aciduria type II: multiple defects in isolated muscle mitochondria and deficient ?-oxidation in fibroblasts.- Glutaryl CoA dehydrogenase activity determined with intact electron-transport chain: application to glutaric aciduria type II.- Medium chain acyl-CoA dehydrogenase deficiency: apparent Km and Vmax values for fibroblast acyl-CoA dehydrogenase towards octanoyl-CoA in patient and control cell lines.- Mitochondrial myopathy with partial cytochrome oxidase deficiency and impaired oxidation of NADH-linked substrates.- L-Carnitine insufficiency in disorders of organic acid metabolism: response to L-carnitine by patients with methylmalonic aciduria and 3-hydroxy-3-methylglutaric aciduria.- An evaluation of urine lactate for detection of inborn errors of metabolism.- Metabolic acidosis versus a compensation of respiratory alkalosis in four children with Leigh’s disease.- Chemical diagnosis of dihydrolipoyl dehydrogenase deficiency.- 3-Hydroxy-3-methylglutaric, 3-methylglutaconic and 3-methylglutaric acids can be non-specific indicators of metabolic disease.- Different organic acid patterns in urine and in cerebrospinal fluid in a patient with biotinidase deficiency.- Biotinidase deficiency: the possible role of biotinidase in the processing of dietary protein-bound biotin.- Biotin-responsive multiple carboxylase deficiency (MCD): deficient biotinidase activity associated with renal loss of biotin.- Organic acids in urine: sample preparation for GC/MS.- Experience with prenatal diagnosis of propionic acidaemia and methylmalonic aciduria.- Methylmalonic aciduria with homocystinuria.- Two cases of ß-ketothiolase deficiency: a comparison.- L-Glyceric aciduria (primary hyperoxaluria type 2) in siblings in two unrelated families.- The antenatal diagnosis and aid to the management of hereditary tyrosinaemia by use of a specific and sensitive GC—MS assay for succinylacetone.- The enzyme defects in hereditary tyrosinaemia type I.- The possibility for prenatal diagnosis of PKU by linkage analyses based on phenylalanine hydroxylase locus specific DNA-polymorphisms.- Complementation between argininosuccinate synthetase-deficient and argininosuccinate lyase-deficient fibroblasts depends on intercellular communication.- Molecular lesion of non-ketotic hyperglycinaemia.- Prolidase deficiency: detection of cases by a newborn urinary screening programme.- Type Ib glycogen storage disease: an in vivo and in vitro study of two cases.- The lactate concentration of the urine, a parameter for the adequacy of dietary treatment of patients with glucose-6-phosphatase deficiency.- Sorbitol dehydrogenase deficiency in a family with congenital cataracts.- Thiamin-responsive megaloblastic anaemia: a disorder of thiamin transport?.- Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms.- Steroid sulphatase deficiency. Steroid sulphatase and arylsulphatase C determination in normal and affected fibroblasts.- Steroid sulphatase deficiency is present in patients with the syndrome’ ichthyosis and male hypogonadism’ and with’ Rud syndrome’.
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Springer Medico-Social Management of Inherited Metabolic Disease: A Monograph Derived from The Proceedings of the Thirteenth Symposium of The Society for the Study of Inborn Errors of Metabolism
Book SynopsisThe study of inherited metabolic disease became a subject of more than academic interest in 1953 when Bickel, Gerrard and Hickmans dis covered that the totally disabling consequences of phenylketonuria could be prevented if treatment was instituted in the first months of life. This required the widespread screening of all newborn babies and 7 years later this had been successfully achieved in the United King dom. The next 10 years was a period of consolidation: screening methods were improved and extended to include other disorders; treatment of phenylketonuria was vastly improved with the stimulus of the increasing numbers of patients being detected, and research into new forms of therapy for some of the other disorders being detected has been initiated. The success of this scheme is illustrated by the remarkable achievement reported by the Phenylketonuria Registry referred to in the present volume. But at what cost has this progress been made? It is unnecessary to discuss the financial cost for many of the developments would not have been started if their economic value in the system of health care had not been unequivocally established.Table of ContentsThe Nature and Size of the Problem.- 1 The need for a national policy for the management of inherited metabolic disease.- 2 Genetic screening and allied services: structure, process and objective.- Present Methods of Management.- 3 The role of the paediatrician.- 4 Management of dietary treatment in the home.- 5 Residential management.- Community Reaction to Present Practice.- 6 Parent reaction to medical care and screening.- 7 Screening for Tay—Sachs disease.- 8 Genetic counselling clinics.- 9 The coming of the second genetic code: eugenic abortion in the United Kingdom.- Aspects of Management Requiring Central Policy.- 10 The basis for prescriptive screening.- 11 Resources for nutritional treatment: basic principles and a national ‘Food Bank’.- 12 Detection of heterozygotes.- 13 Prenatal diagnosis.- 14 The phenylketonuria register for the United Kingdom.- 15 Computerized central registers.- 16 Mechanized storage and retrieval of information.- 17 Computer-aided diagnosis of inherited metabolic disease.- The Fourth Milner Lecture.- 18 The biochemical autopsy: a tool for studies of genetically-determined brain disorders.
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Springer Inborn Errors of Immunity and Phagocytosis: Monograph based upon Proceedings of the Fifteenth Symposium of The Society for the Study of Inborn Errors of Metabolism
Book SynopsisThe rapid growth of immunology has greatly increased our understanding of disease; this growth has also generated a subject which at times appears separated from some of the basic medical sciences. Recent studies in the areas of purine metabolism and of polymorphonuclear neutrophil phago cyte function have, however, linked immunology and clinical medicine with biochemistry. The precise defects of the inborn errors of metabolism have now provided good evidence for the importance of purine metabolism specifically the enzymes adenosine deaminase and nucleoside phosphorylase in lymphocyte function. In view of this and the steady advance of clinical and biochemical investigation of the polymorphonuclear neutrophil phago cyte, it appeared timely to review the inborn errors of immunity and phagocytosis at the fifteenth annual symposium of the Society for the Study of Inborn Errors of Metabolism at Elsinore, Denmark on September II-14th, I~77. The papers presented at that meeting form the basis of this volume which brings together contributions from immunologists, biochemists and clinicians. This interdisciplinary communication should be helpful to those concerned with immune function in their patients or in the laboratory. The book is divided into four sections, One: defects of cell-mediated immunity, Two: enzyme defects and immunodeficiency, Three: disorders of non-specific immunity and Four: screening for immunodeficiency. Section One contains two reviews, one on immunodeficiency from Robert Good's group in New York and another on the genetics of the immune system from Arne Svejgaard of Copenhagen.Table of ContentsSection One Defects of Cell-mediated Immunity.- 1 Immunodeficiency diseases — a review.- 2 Genetics of the immune system.- Section Two Enzyme Defects and Immunodeficiency.- 3 Inborn errors of specific immunity: adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency — The Milner Lecture.- 4 Adenosine deaminase deficiency: enzyme replacement therapy and investigations of the biochemical basis of immunodeficiency.- 5 Prenatal diagnosis and heterozygote detection in adenosine deaminase deficiency.- 6 Pathogenic mechanisms in deficiencies of adenosine deaminase and purine nucleoside phosphorylase.- 7 Purine nucleoside phosphorylase deficiency associated with cellular immunodeficiency: immunological studies during treatment.- 8 Purine nucleoside phosphorylase deficiency associated with cellular immunodeficiency: metabolic studies during treatment.- 9 Severe combined immunodeficiency with B lymphocytes: a selective defect of precursor T cells.- 10 Purine metabolism and the control of lymphocyte proliferation. Effects of exogenous adenosine on normal human lymphocytes.- 11 Activity of adenosine deaminase and purine nucleoside phosphorylase in lymphocytes of man, horse and cattle.- 12 Ageing and activities of purine metabolizing enzymes in leukocytes.- 13 Immune function in Down’s syndrome.- Section Three Disorders of Non-specific Immunity.- 14 Morphological and biochemical alterations of polymorphonuclear neutrophil (PMN) leukocytes from patients with inborn errors of phagocytic function: a comprehensive review.- 15 Experimental approaches to the role of mononuclear phagocytes in non-specific immunity.- 16 Molecular bases of the metabolic excitability of phagocytes.- 17 Chronic granulomatous disease — biochemistry with special reference to oxygen metabolism.- 18 The protective role of glutathione.- 19 Defective initiation of the metabolic stimulation in phagocytizing granulocytes.- 20 Modification of genetic expression in phagocytes.- 21 Neutrophil granulocyte chemotaxis in a reversible Boyden chamber.- 22 Simplified tests of leukocytic function.- 23 Antigen-induced neutrophil dysfunction in a patient with chronic eczema, recurrent ‘cold’ staphylococcal infections and hyperimmunoglobulinaemia E.- 24 Lack of myeloperoxidase-mediated iodination in granulocytes from a patient with generalized pustular psoriasis.- 25 Functional characteristics of neutrophil granulocytes from children with recurrent respiratory infections.- 26 Pneumocystis carinii infection in a girl with chronic granulomatous disease treated with transfusions of granulocytes.- Discussion.- Section Four Screening for Immunodeficiency.- Round Table Discussion.
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Springer Inborn Errors of Skin, Hair and Connective Tissue: Monograph Based Upon Proceedings of the Eleventh Symposium of The Society for the Study of Inborn Errors of Metabolism
Book SynopsisFollowing the pattern of previous years the 11th symposium of the S.S.I.E.M. held in the beautiful sylvan surroundings of Sussex Univ ersity, concentrated on a relatively small section of the field of inborn errors. The subject chosen-Inborn Errors of Skin, Hair and Con nective Tissue, was a highly topical one. Intensive research during the last few years particularly on the structure and disorders of connective tissue has considerably advanced our knowledge on this subject. We believe that the range of diseases covered, and the depth in which they were discussed, made this meeting unique. The proceedings contain much original material and reference information which should make them an invaluable addition to the literature on metabolic disorders. The work involved is multi-disciplinary involving among others physicists, organic chemists, biochemists, clinical chemists, paedia tricians, physicians, geneticists and neurologists. The bringing together of workers of many disciplines to contribute to the particular subject under discussion at our Symposia has always been an important objective of the Society. In this case we were very fortunate in gathering together experts from all the fields mentioned above. In particular we were honoured that Professor A. Dorfman of Chicago could accept our invitation to give the second Milner Lecture. We were also privileged to have some excellent contributions from the research scientists on whom we must rely for our ultimate understanding of the diseases, and rational approach to treatment.Table of ContentsInborn Errors and Skin.- 1 Inborn errors of skin.- Inborn Errors and Hair.- 2 Inherited conditions affecting the proteins of hair.- 3 Some aspects of the use of hair follicles for the biochiemcal study of inborn errors of metabolism.- Inborn Errors of Connective Tissue.- 4 Morphological aspects of the mucopolysaccharidoses.- 5 Glycosaminoglycans of foetal tissue in two cases of Hurler’s syndrome.- 6 The mucolipidioses: with special reference to I-cell disease.- 7 Structure and biosynthesis of collagen.- 8 Biosynthesis of collagen cross-links : relationship of heritable disorders.- 9 Molecular conformations of connective tissue mucopolysaccharides.- 10 Mucopolysaccharides in ageing.- 11 Genetic aspects of mucopolysaccharidoses with special reference to heterozygous carriers.- The Second Milner Lecture.- 12. Genetic defects of the degradation of glycosaminoglycans: the mucopolysaccharidoses.- 13 Chemistry of dermatan sulphate accumulated intracellularly in Hunter’s disease.- 14 The treatment of genetic mucopolysaccharidoses.- Laboratory Aspects of the Mucopolysaccharides Including diagnosis and screening.- 15 The laboratory diagnosis of the mucopolysaccharidoses.- 16 Screening newborns for mucopolysaccharidoses.- 17 Acid glycosaminoglycan excretion in the mucopolysaccharidoses: determination of glycosaminoglycans in urine and amniotic fluid using new micro-analytical techniques.- 18 An evaluation of methods suitable for a clinical laboratory study of abnormal glycosaminoglycan excretion.
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Springer Nutrition and Exercise in Obesity Management
Book SynopsisIt is a pleasure to present, Nutrition and Exercise in Obesity Management, for reference and textbook use. The text is an outgrowth of the Obesity Weight Control Track of the 1982 La Crosse Health and Sports Science Symposium, sponsored annually by the La Crosse Exercise Program, University of Wisconsin-La Crosse. With versatile faculty, topics, and attending professionals, the Obesity-Weight Control Track stimulated an effort to produce interdisciplinary resources on obesity. Out of this effort, three books have been compiled and edited. The first book, Evaluation and Treatment of Obesity, introduces an inter disciplinary, practical approach to obesity management. This book, Nutrition and Exercise in Obesity Management, compiles the information specifically related to nutrition and exercise management of obese indi viduals. The third book, Behavioral Management of Obesity, relates be havioral theories to the modification of eating habits and activity patterns. These three books apply the latest information from the fields of medi cine, nutrition, exercise, and psychology to the problem of obesity. The information is intended to guide health professionals in the interdisci plinary management of obesity. In 1983 the Obesity-Weight Control Track focused on controversial issues of theoretical and practical concern. The speakers from this track contributed their expertise to the compilation of two additional books. Thus, Trends and Controversies in Obesity Research and Innovation in Obesity Program Development will complete the series. Consider the five volumes a consolidated, comprehensive reference related to the growing, interdisciplinary field of weight control.Table of Contents1. Review of Popular Diets.- 2. Nutritional Management of the Obese Individual.- 3. Protein-Sparing Modified Fasting and Behavior Therapy.- 4. Myths and Misconceptions in Exercise for Weight Control.- 5. Exercise Testing and Training for the Obese.- 6. Exercise Concerns and Precautions for the Obese.
£40.49
Springer Principles of Biological Control
Book SynopsisThe study of the normal function of the animal and human organisms and of the diseases which disturb that normal func tion is largely the study of control mechanisms. These control mechanisms are essential for the survival of an organism in a more or less hostile environment. In many ways they clearly resemble the control mechanisms devised by electronic engin eers for running machinery of all kinds and there are many remarkable parallels between biology and engineering. However, it should not be forgotten that the biological systems were on the scene first and that the engineering is a parallel and independent development. It is therefore perhaps a pity that in recent years the study of biological control systems has tended to be dominated by mathematicians and engineers who have moved from these more precise disciplines into biology. As a consequence of this dominance, one often gets the impression that the principles of biological control can be understood only after one has undergone a rather high-powered course in elec tronic control theory. It often seems to be assumed that it is electronics which must do all the teaching while biology and medicine must do all the learning. In fact I suspect that biolo gical control mechanisms are considerably more sophisticated than anything yet available in the world of the physical sciences and that in the long run biology will teach more to control engineers than vice versa.Table of Contents1 Introduction.- 2 Basic principles of control.- 3 Negative and positive feedback.- 4 The value of disturbance detectors.- 5 The influence of the type of stress on the design of a control system.- 6 Systems with multiple detectors and multiple effectors.- 7 Alteration of the behaviour of control mechanisms.- 8 Implications for research.- 9 Application of control theory to a particular research problem-high arterial pressure.- Further reading.- Appendix-renal hypertension.
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£40.49
Springer A short history of breast cancer
Book SynopsisThe Third Breast Cancer Working Conference of the Breast Cancer Cooperative Group of the European Organization for Research on Treatment of Cancer, to be held in Amsterdam on April 27-29, 1983, was the principle motive for writing this book. It was feh that a short review of the main pathogenetic conceptions and therapeutic principles which have presented themselves with regard to mammary cancer in the Course of Western history , might help to draw a more complete picture of where we stand today. It is not easy to decide which ideas, although discarded, deserve yet to be remembered and which authors from the past may be considered to be truly representative of the scientific climate of their age. Twenty centuries have produced quite a lot of ideas and the number of medical authors who advanced, or rejected, or modified, or revived them, is really uncountable. So the historian has to make a selec tion and choices are perforce subjective and open to criticism. In writing this book I tried to consult original sources in the original language as much as possible. These sources were not always strictly medical since I aimed at placing the problem of malignant breast disease - which might serve as a paradigm of cancer in general - in a somewhat wider context. For the history of medicine is not only a history of ideas, but also that of people, of institutions, of society.Table of Contents1. Antiquity.- 2. The Middle Ages.- 3. The Renaissance.- 4. Pathophysiological concepts in the Age of Enlightenment.- 5. Diagnosis and therapy in the eighteenth century.- 6. Europe during Napoleon and after.- 7. Scientific developments in the second half of the nineteenth century.- 8. Mammary carcinoma in the light of new developments.- 9. Surgical treatment in the second half of the nineteenth century.- 10. The twentieth century.- Epilogue.- Notes.- Index of names.
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Springer Multidisciplinary Management of Liver Metastases in Colorectal Cancer: Early Diagnosis and Treatment
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£116.99
Springer Verlag, Singapore Introduction to Biliary Atresia
Book SynopsisThis book offers a comprehensive overview of the latest standard medical procedures and surgical techniques for biliary atresia (BA), as well as the perioperative care, long-term follow-up and transitions. Experts on pediatrics in such fields as hepatology, surgery, pathology, and liver transplantation present their research findings and analyses of this rare and intractable disease of unknown etiology. In Japan, shared experience and sound understanding based on conferences and guidelines have led to standardization of management and clinical care and, as a result, better outcomes. Providing insights into improving surgical outcomes, and including special chapters focusing on social support systems for patients and families as well as recent advances in early diagnosis, this book a valuable resource for medical professionals around the globe who are involved in treating biliary atresia. It is especially useful for pediatric hepatologists, pediatric surgeons and transplant surgeons.Table of ContentsBiliary Atresia: A Historical OverviewHistory of The Japanese Biliary Atresia Society (JABS)Japanese Biliary Atresia Registry (JBAR)Pathogenesis: Overview Pathogenesis: Genetics/EpigeneticsPathogenesis: Viral InfectionPathogenesis: Maternal Microchimerism Epidemiology: Incidence and Gender RatioEpidemiology: Ethnic Variations/Family Histories/HeredityEpidemiology: Gestational Age/Birth Weight /Associated AnomaliesClassifications Mass Screening Stool Color Card System Prenatal Diagnosis and Signs/SymptomsIntracranial HemorrhagePathology Biomarkers Differential Diagnosis Diagnostic Modalities Preoperative Management and Direct CholangiographyOperative Procedures: Open Kasai ProcedureOperative Procedures: Laparoscopic Kasai ProcedureOperative Procedures: Re-do Kasai ProcedureOperative Procedures: Cadaveric Liver TransplantationOperative Procedures: Living Donor Liver TransplantationMedical Treatment: UDCA/Steroid Medical Treatment: Kampo MedicinePrevention/Treatment of Postoperative CholangitisNutritional Support Protocols of Follow-up ManagementPrognostic IndicatorsLong-term Complications: Gastro-Esophageal VaricesLong-term Complications: Hypersplenism Long-term Complications: Cholangitis/Gall StonesLong-term Complications: Hepatopulmonary SyndromeLong-term Complications: Portopulmonary HypertensionLong-term Complications: Liver Cirrhosis/Hepatic Encephalopathy Long-Term Results, GeneralLong-Term Results, Deformity of Intrahepatic Bile DuctsLong-Term Results, Social Performance Long-Term Results, Liver Transplantation Biliary Atresia and Pregnancy/Delivery Biliary Atresia and Malignancy Future Prospects Transition in Biliary Atresia Society of Patients and Families Clinical Guidelines for Biliary Atresia
£999.99
Springer Verlag, Singapore Pharmacokinetics: Basics to Applications
Book SynopsisThis textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.Table of ContentsChapter 1: Fundamentals of Pharmacokinetics.- Chapter 2: Drug absorption.- Chapter 3: The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding.- Chapter 4: Pharmacokinetic models and drug distribution.- Chapter 5: Drug metabolism .- Chapter 6: Drug elimination and nonlinear kinetics.- Chapter 7: Pharmacokinetic drug-drug interactions.- Chapter 8: Pharmacokinetic applications.- Chapter 9: Pharmacokinetic sample collection and processing.- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics.- Chapter 11: Statistics in pharmacokinetics.- Chapter 12: Pharmacokinetic software and tools.- Chapter 13: Pharmacokinetic laboratory-based experiments.- Chapter 14: Pharmacokinetic numerical problems with solutions.- Chapter 15: Questions, and questions & answers for practice.
£54.99
Oxford University Press Oxford Handbooks Clinical Tutor Study Cards
Book SynopsisFully updated for the second edition, these handy pocket-sized study cards remain an innovative and versatile revision solution. Containing vital techniques and tips, the study cards condense revision into short essential bursts. Ideal for revising quickly on the move, students can also use them when carrying out examinations, or as a reminder before ward rounds and teaching sessions. Arranged into clear sections, the cards allow the reader to find and digest topics easily, whilst full colour illustrations aid quick and confident diagnoses. Taking a system-based approach, the set covers all essential diseases and syndromes in just 166 double-sided cards. Each card first describes the clinical examination and symptoms, before covering the need-to-know essentials: aetiology, indications, differential diagnoses, complications and suitable investigations. The final part of each card covers the treatment or management of the disease.
£31.19
Anatomical Chart Co. Temporomandibular Joint (TMJ) Anatomical Chart
Book Synopsis
£25.98
Elsevier - Health Sciences Division Physical Diagnosis Secrets
Book SynopsisTable of ContentsTop 100 Secrets 1. General Appearance, Facies, and Body Habitus 2. Vital Signs 3. The Skin 4. The Eye 5. The Ear 6. Nose and Mouth 7. The Neck 8. The Thyroid 9. The Breast 10. The Cardiovascular Exam 11. Heart Sounds and Extra Sounds 12. Heart Murmurs 13. Chest Inspection, Palpation, and Percussion 14. Lung Auscultation 15. The Abdomen 16. Male Genitalia, Hernias, and Rectal Exam 17. Female Genitalia and the Pelvis 18. Lymph Nodes 19. The Neurologic System 20. The Musculoskeletal System 21. The Extremities and Peripheral Vascular System
£35.99
Elsevier Health Sciences Talley and OConnors Examination Medicine
a huge range and FREE tracked UK delivery on ALL orders.
£83.99
Pharmaceutical Press Handbook of Drug Administration via Enteral
Book SynopsisThe Handbook of Drug Administration via Enteral Feeding Tubes furnishes you with the background knowledge to inform clinical decision making as well as providing over 400 drug monographs.Trade Review"5 stars!...drug monographs are organized in a way that allows quick access to information and it is very easy to determine if the medication is safe to be administered through the enteral route. Information is current and properly referenced...This is a convenient and useful guide to have on the medical floor as a point of care reference for nurses, pharmacists, or any healthcare providers..." Melissa M. Ranieri, BS, PharmD, Doody's Notes, May 2015. -- Melissa M. Ranieri * Doody's Notes *Table of Contents1. Introduction; 2. Types of enteral feeding tubes; 3. Flushing enteral feeding tubes; 4. Restoring and maintaining patency of enteral feeding tubes; 5. Drug therapy review; 6. Choice of medication formulation; 7. The legal and professional consequences of administering drugs via enteral feeding tubes; 8. Health and safety and clinical risk management; 9. Syringes and ports; 10. Defining interactions; 11. Medicines optimisation; Individual drug monographs.
£999.99
Johns Hopkins University Press Precepting Medical Students in the Office
Book SynopsisAs medical education curricula continue to evolve, many medical schools are implementing programmes which allow students to spend a portion of their time observing primary care physicians in their offices. This is a how-to guide to educating medical students in the patient-care setting.Trade ReviewThe editors are to be applauded for giving us an excellent how-to-manual devoted to this essential aspect of the art of medical education. Journal of the American Board of Family PracticeTable of ContentsForewordPrefaceList of ContributorsPart I: Introduction to Community-Based PreceptingChapter 1. The History and Value of PreceptorshipsChapter 2. How Do I Get Involved in Precepting?Chapter 3. Pitfalls of PreceptingPart II: Characteristics and Needs of LearnersChapter 4. What Medical Students Want and Need From a PreceptorshipChapter 5. Learning Needs of Medical Students Chapter 6. The Teaching MomentPart III: Clinical TeachingChapter 7. Learning During the PreceptorshipChapter 8. Being a Role ModelChapter 9. Integrating the Student Into the Practice Chapter 10. Orienting Medical StudentsChapter 11. Learning ContractsChapter 12. Using Goals and Objectives in Community RotationsChapter 13. SupervisionChapter 14. Teaching and Learning StylesChapter 15. Formative FeedbackChapter 16. Summative Feedback, Evaluation, and Grading StudentsChapter 17. Advising From a Preceptor's PerspectiveChapter 18. Dealing with Learners at Different LevelsChapter 19. Dealing with the Problem LearnerPart IV: Organization of the Preceptorship CurriculumChapter 20. The Ideal PreceptorshipChapter 21. Reinventing the Community-Based PreceptorshipChapter 22. Costs of Precepting and How to DecreaseChapter 23. LogisticsChapter 24. Involving Your Office Staff in TeachingPart V: Relationships to Medical Schools and Other AgenciesChapter 25. Working with Preceptorship Sponsors: Medical Schools and Clinical Departments Chapter 26. Preparing for a Site VisitChapter 27. Working with Local Hospital Administrators Chapter 28. Working with Local Hospital AdministratorsChapter 29. Preceptors in Managed Care OrganizationsPart VI: Legal and Ethical Aspects of PreceptingChapter 30. Liability Issues for PreceptorsChapter 31. Ethics of PreceptingPart VII: Faculty Benefits and ResourcesChapter 32. Support Services and Products Available for Community PreceptorsChapter 33. Electronic Communication for Community PreceptorsChapter 34. Faculty DevelopmentAppendix A. Health Care Financing Administration Rules for Student Documentation in Medicare Patients' ChartsAppendix B. Sample Preceptor-University ContractIndex
£23.85
Johns Hopkins University Press The Medical Care of Terminally Ill Patients
Book SynopsisEnck places great emphasis on enhancing the quality of life while addressing the most common symptoms of terminal illness.Trade ReviewA very well thought out and organized professional book... A thorough book for physicians. -- Carolyn Whitman, M.S., R.N. Inside GCM This Second Edition demonstrates the enormous advances that have been made in the understanding of the treatment of the terminally ill. It provides the clinician with a clear, readable and practical guide to managing clinical problems at the end of life. -- Roger Woodruff International Association for Hospice and Palliative Care Newsletter We can congratulate and thank [Dr. Enck] for adding to the comfort and care of a great many of our fellow human beings as death draws near. Doody's 3-Star ReviewTable of ContentsContents: Preface to the Second Edition List of Abbreviations 1. The Prognostication of Survival Cancer Dementia Motor Neuron Disease Acquired Immunodeficiency Syndrome (AIDS) Central Nervous System Anoxia Advanced Pulmonary Disease Heart Disease Summary I. The Management of Symptoms Common Among Dying Patients 2. General Symtoms of Dying Patients Pain Gastrointestinal Symptoms Nausea and Vomiting Anorexia and Cachexia nutritional Probllmes Hydration Constipation Central Nervous System Symptoms Delirium Depression Systemic Symptoms Dyspnea Urinary Incontinence Pressure Sores Summary 3. Other Problems of Patients with Cancer Malignant Intestinal Obstruction Malignant Dysphagia Neuromuscular Dysfunction Malignant Ulceration Summary 4. Other Problems of Patients with Nonmalignant Diseases Dementia Motor Neuron Disease Acquired Immunodeficiency Syndrom (AIDS) Chronic Vegetative State Advanced Pulmonary Disease Heart Disease Summary 5. Palliative Surgery Principles of Preoperative Care Principles of Operating for Advanced Cancer Principles of Postoperative Care Indications for Surgery Summary II. The Management of Pain 6. An Overview of Pain Management Principles of Pain Management The Ladder Approach Managing the Complications of Pain Treatment Summary 7. Opioids Oral Morphine Parenteral Opioids Alternative Routes of Administration Summary 8. Adjuvant Analgesic Drugs Anticonvulsants Phenothiazines Antidepressants Antihistamines Steroids Antibiotics Amphetamines Butyrophenones Summary 9. Complications of Pharmacologic Therapy Opioids Nonsteroidal Anti-inflammatory Drugs Summary 10. Bone Pain Pathopysiolgoy Radiation Therapy Pharmacotherapy Summary References Index 11. Surgery and Other Nonpharmacologic Interventions to Manage PainSurgery Acupuncture Transcutaneous Electrical Nerve Stimulation Relaxation Techniqu eComplimentary/Alternative Medicine Summary III. The Management of Symptoms During the Last Few Days 12. The Final Moments Terminal Symptoms and Their Managment Drug-Induced Terminal Sedation Summary 13. Issues Concerning the Sustaining of Life Do Not Resuscitate Advance Directives Physician-Assisted Suicide and Euthanasi aSummary References Index
£29.70
Johns Hopkins University Press Supportive Care of Children with Cancer 3e
Book SynopsisThe third edition features a new chapter on recognition, prevention, and remediation of burnout in pediatric oncology staff members, while throughout the book, chapters have been revised and updated to reflect the impact of new antibiotic agents, new antiemetics, and new approaches to pain management.Trade ReviewThe authors have collected very valuable, extensive and up-to-date information on the subjects treated: an ideal reference for all professionals involved in the multidisciplinary care of pediatric cancer patients. -- Susanne Suter European Journal of Pediatrics 2004 This third edition of Supportive Care of Children with Cancer is a highly useful, ready-reference handbook for nurses, medical staff and oncologists involved in paediatric oncology care. Cancer World 2005Table of ContentsForewordPrefaceAbbreviationsList of ContributorsChapter 1. The Prevention of InfectionChapter 2. ImmunizationChapter 3. The Management of Fever and NeutropeniaChapter 4. Blood Component TherapyChapter 5. Hemorrhagic and Thrombotic ComplicationsChapter 6. Hematopoietic Growth FactorsChapter 7. Monitoring and Management of Drug Toxicity Chapter 8. The Management of Drug Extravasation Chapter 9. Side Effects of Radiation TherapyChapter 10. Chemotherapy-Induced Nausea and VomitingChapter 11. The Management of Pain Chapter 12. Oncologic EmergenciesChapter 13. Nutritional SupportChapter 14. Mouth CareChapter 15. Central Venous AccessChapter 16. The Sexually Mature Young Adult Patient With CancerChapter 17. Care of the Hematopoietic Stem Cell Transplant Patient After Leaving the Transplant CenterChapter 18. Psychosocial CareChapter 19. Recognition, Prevention, and Remediation of Burnout in Pediatric Oncology StaffChapter 20. Complementary and Alternative Medicine in Pediatric OncologyChapter 21. Palliative CareIndex
£31.50
Johns Hopkins University Press The Foot Book
Book SynopsisNow completely revised and updated! The ultimate guide to taking care of your feet. Written by leading experts with decades of experience in podiatry, this new edition of The Foot Book covers everything you need to know to care for your feet. It addresses the entire foot, inside and out, describing in plain English its anatomy and biomechanical operations. The second edition also: Provides an overview of common and rare foot injuries and syndromes Includes information on alignment and balance problems, heel pain, skin and toe conditions, flat feet, arthritis, and more Offers guidance on medications, exercises, stretches, inserts, therapy, and surgery Explains how to select the right footwear and provides shoe recommendations Covers foot issues in children, athletes, people with diabetes, and people with nerve or vascular problems Includes links to supplemental videos that guide you through stretching, flexibility, and strengthening exercisesIllustrated with nearly 100 images, The FoTable of ContentsPrefacePart I. IntroductionChapter 1. A Guide to the Foot and How We WalkChapter 2. Personal Care and Professional Help for FeetChapter 3. About ShoesPart II. Foot Disorders and Other ProblemsChapter 4. Foot Alignment ProblemsChapter 5. Flat Feet and High-Arched FeetChapter 6. Skin Conditions Affecting the FootChapter 7. Toenail DisordersChapter 8. Bunions and Other Toe Conditions Chapter 9. Heel PainChapter 10. Nerve Syndromes Affecting the Foot and AnkleChapter 11. Arthritis Affecting Foot and Ankle JointsChapter 12. Tendon InjuriesPart III. People with Special Foot NeedsChapter 13. Foot Problems That Start in ChildhoodChapter 14. Common Sports Injuries and the Sports Enthusiast's FootChapter 15. Foot Health for People with DiabetesChapter 16. Orthotic Devices to Alleviate Foot ProblemsChapter 17. Puncture Wounds and Foreign BodiesResourcesIndex
£18.45
John Wiley & Sons Inc Pocket Guide to Teaching for Clinical Instructors
Book SynopsisThe Pocket Guide to Teaching for Clinical Instructors, 3rd edition, provides a concise introduction to teaching. Written by experienced medical educators from the Advanced Life Support Group and Resuscitation Council (UK), this best-selling guide gives comprehensive and practical advice on the most effective teaching methods. Pocket Guide to Teaching for Clinical Instructors covers basic principles and practical aspects of teaching in a variety of modalities. This edition includes material which reflects current developments within instructor courses and includes new material on feedback, an awareness of non-technical skills, the teaching of teams and supporting learners. This book is essential reading for anyone interested in teaching doctors and healthcare professionals in any context. It is aimed at the relative newcomer to the teaching role in all its variety and provides essential, practical advice as to how to get the best out of learners.Table of ContentsWorking group vii Contributors to the third edition ix Contributors to the first and second editions xi Foreword xiii Preface to the third edition xvii Preface to the first edition xix Acknowledgments xxi 1 Adult learning 1 2 A structured approach to teaching 11 3 Lecturing effectively 15 4 Teaching skills 27 5 Managing simulations 33 6 Facilitating discussions 43 7 Getting assessment right 51 8 Feedback 59 9 e-Learning 69 10 Supporting learning 75 11 Teaching teams 81 Index 85
£22.75
John Wiley and Sons Ltd Pediatric Incontinence
Book SynopsisPediatric incontinence: evaluation and clinical management offersurologists practical,''how-to'' clinical guidance towhat is a verycommon problem affecting up to 15% of children aged 6 years old. Introductory chapters cover theneurophysiology, psychological and genetic aspects, as well as theurodynamics of incontinence, before it moves on to itscore focus, namelythe evaluation and management of the problem. All types of management methods will be covered, including behavioural, psychological, medical and surgical, thus providing the reader with a solution to every patient''s specific problem. The outstanding editor team led by Professor Israel Franco, one of the world's leading gurus of pediatric urology, have recruited a truly stellarteam of contributors each of whom haveprovided first-rate, high-quality contributions on theirspecific areas of expertise.Clear management algorithms for each form of treatment support the text, topics of controversyare covereTable of ContentsList of contributors xi Preface xv Section 1: Pathophysiology of bowel and bladder dysfunctionIsrael Franco 1 Neurophysiology of voiding 3Oreoluwa Ogunyemi and Hsi‐Yang Wu 2 Neurophysiology of defecation 15Cecilie Ejerskov and Charlotte Siggaard Rittig 3 Functional brain imaging in bowel and bladder control 21Israel Franco Section 2: Epidemiological aspects of bowel and bladder dysfunctionAlexander von Gontard 4 The epidemiology of childhood incontinence 37Anne J. Wright 5 Quality of life factors in bladder and bowel dysfunction 61Eliane Garcez da Fonseca 6 Psychological aspects in bladder and bowel dysfunction 67Alexander von Gontard 7 Neuropsychiatric disorders and genetic aspects of bowel or bladder dysfunction 73Israel Franco Section 3: Evaluation of bowel and bladder dysfunctionYves Homsy 8 Urodynamics in the pediatric patient 91Beth A. Drzewiecki and Stuart B. Bauer 9 Uroflowmetry and postvoid residual urine tests in incontinent children 99Stephen Shei‐Dei Yang and Shang‐Jen Chang 10 Evaluation of the child with voiding dysfunction 107Yves Homsy 11 Evaluation of constipation and fecal incontinence 121Marc A. Benninga Section 4: Treatments of functional bowel and bladder dysfunctionPaul F. Austin 12 Implementation of urotherapy 133Wendy F. Bower and Janet W. Chase 13 The concept of physiotherapy for childhood BBD 139Janet W. Chase and Wendy F. Bower 14 Biofeedback for the treatment of functional voiding problems 145Ann Raes and Catherine Renson 15 Pharmacotherapy of the child with functional incontinence and retention 153Paul F. Austin and Israel Franco 16 Treatment of functional constipation and fecal incontinence 163Vera Loening‐Baucke and Alexander Swidsinski 17 Peripheral tibial nerve stimulation therapy for the treatment of functional voiding problems 171Mario De Gennaro and Maria Luisa Capitanucci 18 Sacral nerve stimulation therapy for the treatment of functional voiding problems 175Alonso Carrasco Jr, Moira E. Dwyer, and Yuri E. Reinberg 19 Superficial stimulation therapy for the treatment of functional voiding problems 183Ubirajara Barroso, Jr 20 Botulinum toxin in the treatment of the functional bladder 189Luitzen‐Albert Groen and Piet Hoebeke 21 Psychological management of BBD 201Monika Equit and Alexander von Gontard Section 5: Nocturnal enuresisIsrael Franco 22 Pathophysiology of nocturnal enuresis 209Soren Rittig and Konstantinos Kamperis 23 Evaluation of the enuretic child 221Tryggve Neveus 24 Management of monosymptomatic nocturnal enuresis (enuresis) 227Johan Vande Walle 25 Psychological aspects in evaluation and management of nocturnal enuresis (NE) 245Dieter Baeyens and Alexander von Gontard Section 6: Neurogenic bladder and bowel dysfunctionStuart Bauer 26 Diagnostic evaluation in children with neurogenic bladder 257Tom P.V.M. de Jong, Aart J. Klijn, Pieter Dik and Rafal Chrzan 27 Medical management of the neurogenic bladder 263Paul F. Austin and Stuart B. Bauer 28 Treatment of constipation and fecal incontinence: Neuropathic 273Mark P. Cain 29 Neuromodulation for neurogenic bladder in pediatric spinal dysraphism 281Elizabeth B. Yerkes and William E. Kaplan 30 Botulinum toxin in the treatment of neuropathic lower urinary tract dysfunction 293Paul F. Austin and Israel Franco 31 The surgical management of the neurogenic bladder 299Elias Wehbi and Antoine E. Khoury 32 Surgery for bowel dysfunction 309Terry L. Buchmiller 33 Neurological surgery for neurogenic bladder dysfunction 317Michael S. Park and Gerald F. Tuite Index 327
£87.26
Mac Keith Press Examination of the Child with Minor Neurological
Book SynopsisThis highly practical book brings the examination of minor neurological dysfunction developed by Bert Touwen and his colleagues in Groningen right up to date, which is timely in view of the increasing interest in and use of this approach. The approach is a detailed and extensive neurological examination with the aim of detecting a possible neurobiological basis for learning, behavioural and motor coordination problems in a child and thus informing decision-making and management. It provides a refined, sensitive and age-appropriate technique, designed to take into account the developmental aspects of the child’s rapidly changing nervous system. This third edition of Bert Touwen’s classic handbook has been updated by Mijna Hadders-Algra to reflect contemporary clinical practice. A new chapter assesses the reliability and validity of the methodology, and the book now includes norms for comparison, as well as practical management guidelines based on current clinical practice. Entirely new photographs and diagrams illustrate the assessment techniques clearly. Videos illustrating typical and atypical performance and an electronic assessment form accompany the book. Contact admin@mackeith.co.uk for access ReadershipPaediatric neurologists, physicians working in neuropaediatrics, developmental paediatrics, child and adolescent psychiatry, and paediatric rehabilitation.Table of ContentsContents Foreword - Professor Bert C L TouwenForeword - Dr Robert Forsyth1. Introduction2. Assessment of minor neurological dysfunction3. Assessment technique and psychometric properties4. Assessment of the Child Sitting - part I5. Assessment of the Child Standing6. Assessment of the child walking7. Assessment of the child lying8. Assessment of the child sitting - part 29. General data10. Interpretation of findings
£52.25
Wiley-Blackwell TNM Classification of Malignant Tumours 9th Editi
Book Synopsis
£36.05
