Clinical and internal medicine Books

Book SynopsisVolume I is divided into two parts. Part B of volume I in theBen cao gang museries offers a translation of portions of chapter 3 and the complete chapter 4, devoted to pharmaceutical drugs for diseases. This volume is a continuation of volume I, part A. The first portion of chapter 3 is found in part A. TheBen cao gang muis a sixteenth-century Chinese encyclopedia of medical matter and natural history by Li Shizhen (15181593). The culmination of a sixteen-hundred-year history of Chinese medical and pharmaceutical literature, it is considered the most important and comprehensive book ever written in the history of Chinese medicine and remains an invaluable resource for researchers and practitioners. This nine-volume series reveals an almost two-millennia-long panorama of wide-ranging observations and sophisticated interpretations, ingenious manipulations, and practical applications of natural substances for the benefit of human health. Paul U. Unschuld's annotated translation of theBen cao gang mu, presented here with the original Chinese text, opens a rare window into viewing the people and culture of China's past.

Read more less

Book SynopsisThe first edition of this successful reader brought together key readings in the area of developmental cognitive neuroscience for students. Now updated in order to keep up with this fast moving field, the volume includes new readings illustrating recent developments along with updated versions of previous contributions.Trade Review"For child language researchers who wish to gain some background knowledge in this field, we reccommend this volume highly. This text is suitable for academics and students alike. It is an excellent source, and the associated teaching resources available on-line are well constructed and highly useful... The clarity and coherence of the overall argumements contained in the volume make the book a worthwhile component of any developmentalist's library." Vincent Reid & Tricia Striano, Cultural Ontogeny Group, Max Planck Institute for Evolutionary AnthropologyTable of ContentsContributors. Preface.. Part I: Perspectives on Development. Introduction. 1. Critique of the Modern Ethologists Attitude (Konard Lorenz). 2. The Problem of Change (Susan Oyama). 3. The Epigenetic System and the Development of Cognitive Functions (Jean Piaget). 4. From Gene to Organism: The Developing Individual as an Emergent, Interactional, Hierachical System (G. Gottlieb). Part II: Brain Maturation. Introduction. 5. General Principles of CNS Development (R .S. Nowakowski and N.L. Hayes). 6. Intrinsic and Extrinsic Determinants of Neocortial Parcellation: A Radical Unit Model (P. Rakic). 7. Positron Emission Tomography Study of Human Brain Functional Development (Harry T. Chugani, Michael E. Phelps and John C. Mazziotta). 8. Morphometric Study of Human Cerebral Cortex Developemt (Peter R. Huttenlocher). Part III: Brain Maturation and Cognition. Introduction. 9. The Development of Visual Attention: A Cognitive Neuroscience Perspective (Mark H. Johnson). 10. The Ontogeny of Human Memory: A Cognitive Neuroscience Perspective (C.A. Nelson). Part IV: Brain Plasticity. Introduction. 11. Experience and Brain Development (William T. Greenough, James E. Black and Christopher S. Wallace). 12. Do Cortical Areas Emerge from a Protocortex? (Dennis D. M. O'Leary). 13. Emergence of Order in Visual System Development (C.J. Shatz). Part V: Brain Plasticity and Cognition. Introduction. 14. Specificity and plasticity in Neurocognitive Development in Humans (H. Neville and D. Bavelier). 15. Linguistic, Cognitive, and Affective Development in Children with Pre- and Perinatal Focal Brain Injury: A Ten-Year Overview from the San Diego Longitudinal Project (Joan Stiles, Elizabeth A. Bates, Donna Thal, Doris A. Trauner, and Judy Reilly). 16. Cortical Plasticity Underlying Perceptual, Motor, and Cognitive Skill Development: Implications for Neurorehabilitation (Michael M. Merzenich, Beverly A. Wright, William Jenkins, Christina Xerri, Nancy Byl, Steve. Miller and Paula. Tallal). 17. The Instinct to Learn (Peter Marler). Part VI: Self Organization and Development. Introduction. 18. Self-Organization in Developmental Processes: Can system Approaches Work? (Esther Thelen). 19. Development Itself is the Key to Understanding Developmental Disorders. Annette Karmiloff-Smith). 20. Object Recognition and Sensitive Periods: A Computational Analysis of Visual Imprinting (Randall C. O’Reilly and Mark H. Johnson). Part VII: New Directions. Introduction. 21. Connectionism and the Study of Change: Elizabeth Bates and Jeffrey L. Elman). 22. A Model System for Studying the Role of Dopamine in Prefrontal Cortex During Early Development in Humans (Adele Diamond). 23. Genes and Brain: Individual Differences and Human Universals: Bruce F. Pennington). Name Index. Subject Index.

Read more less

Book Synopsisaeo an established bestseller which, in the new edition, is the only current text to give a modern coverage of the subject at this level aeo contains a large number of new illustrations and diagrams aeo covers the significant advances made in our current understanding of the eukaryotic genome.Table of ContentsChemical cytology of the microbial cell; Population growth and death; Substrate uptake and entry to the cell; Energy production; Monomer synthesis; Polymer synthesis and metabolism; Regulation; Growth of individual cells; Morphogenesis and differentiation; Further reading; Glossary; Index

Read more less

Book SynopsisThe first edition of An Aid to the MRCP Short Cases rapidly estabished itself as a classic and has sold over 25,000 copies. The aims of this revised and extended second edition are the same as those of the first: to provide a comprehensive guide for those preparing for the short cases section of the Membership of the Royal College of Physicians examination. The MRCP examination is a major hurdle for all trainee hospital physicians and has a failure rate of over 70%. The largest part of the book consists of 200 short cases that are presented in order of frequency of their occurrence in the examination (based on an extensive survey of successful candidates). The clinical features of each case are fully covered and supported by illustrations and photographs. The emphasis throughout the book is on examination technique and how to present the clinical information in the style that the examiners expect. In short, it is an indispensable guide for anyone pTrade Review"...this is an excellent book, giving good advice on how to become a skilled, thoughtful and knowledgeable physician and hence how to become a MRCP (UK)" Journal of the Royal College of Physicians of London, on the previous edition "The case-by-case approach is useful in preparing for Medicine finals. Together with the examination routines, the book becomes a kind of alternative textbook to conventional clinical examination books such as McCleods." 2nd Opinion, The Magazine of the Scottish Medical Schools "...an invaluable companion to undergraduates in medical finals. It is easy to filter out the more obscure cases but this being said, the vast majority of the information is relevant to House Officers-to-be. This book is excellent value for money; the buy is well worth it." Leech Y Gelen, University of Wales College of Medicine GazetteTable of ContentsPreface to the second edition ix Preface to the first edition xi Introduction xiii Section 1: Preparation 1 Section 2: Examination Routines 7 1 Heart 10 2 Abdomen 14 3 Fundi 18 4 Hands 20 5 Legs 24 6 Chest 28 7 Spot diagnosis 31 8 Eyes 35 9 Face 37 10 Arms 38 11 Neck 42 12 Ask questions 43 13 Pulse 46 14 Visual fields 48 15 Skin 49 16 Gait 51 17 Rash 53 18 Legs and arms 54 19 Cranial nerves 55 20 Thyroid status 58 Section 3: 200 Short Case Records 61 1 Diabetic retinopathy 65 2 Hepatosplenomegaly 69 3 Mitral stenosis (lone) 71 4 Rheumatoid hands 73 5 Mixed mitral valve disease 76 6 Dullness at the lung base 78 7 Splenomegaly (without hepatomegaly) 80 8 Optic atrophy 82 9 Chronic liver disease 84 10 Polycystic kidneys 86 11 Paget’s disease 87 12 Psoriatic arthropathy/psoriasis 90 13 Other combinations of mitral and aortic valve disease 93 14 Mixed aortic valve disease 94 15 Systemic sclerosis/CRST syndrome 96 16 Exophthalmos 98 17 Hepatomegaly (without splenomegaly) 101 18 Spastic paraparesis 102 19 Fibrosing alveolitis 103 20 Aortic incompetence (lone) 104 21 Hemiplegia 106 22 Old tuberculosis 108 23 Acromegaly 109 24 Aortic stenosis (lone) 112 25 Graves’ disease 114 26 Ocular palsy 117 27 Mitral incompetence (lone) 121 28 Motor neurone disease 123 29 Goitre 126 30 Ulnar nerve palsy 129 31 Visual field defect 131 32 Peripheral neuropathy 134 33 Hypertensive retinopathy 136 34 Resuscitation Annie 138 35 Cerebellar syndrome 142 36 Retinitis pigmentosa 144 37 Carcinoma of the bronchus 145 38 Parkinson’s disease 148 39 Chronic bronchitis and emphysema 150 40 Hypothyroidism 152 41 Osler–Weber–Rendu syndrome 155 42 Abdominal mass 157 43 Dystrophia myotonica 159 44 Bronchiectasis 161 45 Wasting of the small muscles of the hand 162 46 Generalized lymphadenopathy 165 47 Papilloedema 166 48 Diabetic foot 168 49 Nystagmus 171 50 Old choroiditis 174 51 Neurofibromatosis (von Recklinghausen’s disease) 176 52 Erythema nodosum 178 53 Horner’s syndrome 180 54 Old polio 182 55 Ankylosing spondylitis 184 56 Abnormal gait 186 57 Irregular pulse 189 58 Single palpable kidney 190 59 Ascites 191 60 Sturge–Weber syndrome 193 61 Necrobiosis lipoidica diabeticorum 195 62 Ventricular septal defect 197 63 Lower motor neurone VIIth nerve palsy 198 64 Clubbing 201 65 Retinal vein thrombosis 203 66 Eisenmenger’s syndrome 205 67 Crohn’s disease 207 68 Mitral valve prolapse 209 69 Cervical myelopathy 211 70 Patent ductus arteriosus 213 71 Tricuspid incompetence 214 72 Purpura 215 73 Xanthomata 218 74 Drug-induced extrapyramidal syndrome 220 75 Bilateral parotid enlargement/Mikulicz’s syndrome 221 76 Primary biliary cirrhosis 222 77 Lupus pernio 224 78 Muscular dystrophy 226 79 Prosthetic valves 228 80 Addison’s disease 229 81 Cushing’s syndrome 231 82 Friedreich’s ataxia 234 83 Peutz–Jeghers syndrome 236 84 Systemic lupus erythematosus 237 85 Superior vena cava obstruction 239 86 Vasculitis 241 87 Deep venous thrombosis/Baker’s cyst/cellulitis 244 88 Cor pulmonale 247 89 Myelinated nerve fibres 248 90 Charcot–Marie–Tooth disease 249 91 Cataracts 251 92 Idiopathic haemochromatosis 253 93 Chest infection/consolidation/pneumonia 255 94 Coarctation of the aorta 256 95 Bulbar palsy 257 96 Choreoathetosis 258 97 Dysarthria 260 98 Dysphasia 261 99 Ehlers–Danlos syndrome 263 100 Erythema ab igne 265 101 Marfan’s syndrome 267 102 Myasthenia gravis 269 103 Osteoarthrosis 272 104 Raised jugular venous pressure 274 105 Pretibial myxoedema 275 106 Retinal artery occlusion 277 107 Vitiligo 279 108 Tophaceous gout 282 109 Fallot’s tetralogy with a Blalock shunt 284 110 Slow pulse 285 111 Guillain–Barré syndrome (acute inflammatory demyelinating polyradiculopathy) 286 112 Pneumonectomy/lobectomy 288 113 Obesity/pickwickian syndrome 290 114 Dermatomyositis 293 115 Hypopituitarism 295 116 Swollen knee 297 117 Pseudobulbar palsy 299 118 Pemphigus/pemphigoid 300 119 Syringomyelia 303 120 Tuberculosis/apical consolidation 305 121 Rheumatoid lung 307 122 Tuberous sclerosis/adenoma sebaceum 308 123 Proximal myopathy 310 124 Pseudoxanthoma elasticum 311 125 Radiation burn on the chest 313 126 Subacute combined degeneration of the cord 314 127 Holmes–Adie–Moore syndrome 315 128 Peripheral vascular disease 316 129 Transplanted kidney 318 130 Glaucoma/peripheral field loss 320 131 Nephrotic syndrome 322 132 Jugular foramen syndrome 323 133 Herpes zoster 325 134 Henoch–Schönlein purpura 327 135 Polymyositis 329 136 Argyll Robertson pupils 330 137 Congenital syphilis 331 138 Carpal tunnel syndrome 333 139 Cerebellopontine angle lesion 335 140 Dextrocardia 336 141 Down’s syndrome 337 142 Gynaecomastia 338 143 Absent ankle jerks and extensor plantars 340 144 Lichen planus 341 145 Lateral popliteal (common peroneal) nerve palsy 343 146 Ptosis 345 147 Osteogenesis imperfecta 348 148 Pulmonary stenosis 349 149 Raynaud’s phenomenon 350 150 Turner’s syndrome 352 151 Mycosis fungoides 354 152 Morphoea 356 153 Laurence–Moon–Bardet–Biedl syndrome 358 154 Short stature 360 155 Pseudohypoparathyroidism 362 156 AIDS related 365 157 Porphyria 368 158 Lupus vulgaris 370 159 Cannon waves 372 160 Polycythaemia rubra vera 373 161 Asteroid hyalosis 374 162 Pernicious anaemia 375 163 Dermatitis herpetiformis 377 164 Urticaria pigmentosa (mastocytosis) 379 165 Pneumothorax 380 166 Tabes 381 167 Tylosis 383 168 Klippel–Feil syndrome 385 169 Pendred’s syndrome 387 170 Secondary syphilis 389 171 Ectodermal dysplasia 391 172 Old rickets 393 173 Partial lipodystrophy 395 174 Fabry’s disease 397 175 Subclavian-steal syndrome 399 176 Reiter’s syndrome/keratoderma blenorrhagica 401 177 Carcinoid syndrome 403 178 Infantile hemiplegia 404 179 Pulmonary incompetence 406 180 Hereditary spherocytosis 408 181 Juvenile chronic arthritis 409 182 Cystic fibrosis 411 183 Infective endocarditis 413 184 Malignant melanoma 415 185 Leg oedema 417 186 Acanthosis nigricans 419 187 Drusen 422 188 Yellow nail syndrome 423 189 Klinefelter’s syndrome/hypogonadism 424 190 Keratoacanthoma 428 191 Thalamic syndrome 429 192 Atrial septal defect 430 193 Pyoderma gangrenosum 431 194 Multiple sclerosis 433 195 Felty’s syndrome 435 196 Hypertrophic obstructive cardiomyopathy 436 197 Radial nerve palsy 437 198 Lateral medullary syndrome (Wallenberg’s syndrome) 438 199 Psychogenic/factitious 440 200 Normal 444 Section 4: Experiences Anecdotes Tips Facts and Figures Quotations 445 Experiences 447 The power and range of the candidate’s observations 449 The candidate’s examination technique 451 The clinical competence of the candidate 453 Common errors 454 Look first 455 Double pathology 456 Tell them of the expert that told you 456 Apologies accepted 457 ‘Even though I didn’t mean to say it—I did’ 457 Invigilator’s diaries 458 Fly on the wall—complete accounts 460 Ungentlemanly clinical methods 466 Some experiences written in the first person 466 Miscellaneous ‘pass’ experiences 467 You never know you’ve failed until the list is published 479 Survivors of the storm 483 Some ‘fail’ experiences 486 Downward spirals 491 Anecdotes 493 Some anecdotes in the first person 498 Useful tips 501 Facts and figures 502 Quotations 503 Adopt good bedside manners 503 Practise clinical examination and presentation 504 Get it right 505 Listen obey and do not stray 505 One wrong does not make one fail 506 If you say less they want more 506 If you know it—say it 506 Humility is more persuasive than self-righteousness 507 Keep cool: agitation generates aggression 507 Simple explanations raise simple questions 507 Think straight look smart and speak convincingly 508 You have seen it all before 508 Use your eyes first and most 508 Doing and forgetting 509 Examiners are different 509 Appendices 511 1 Checklists 513 2 Examination frequency of MRCP short cases 517 3 Examination frequency of examiners’ instructions 522 4 Pocket Snellen’s chart 524 5 Texidor’s twinge and related matters 525 6 Colour photographs of some MRCP short cases 527 7 Detailed contents of Section 4 544 Index 547

Read more less

Book SynopsisUsing images and anatomic illustrations, Rad Tech''s Guide to MRI: Imaging Procedures, Patient Care, and Safety provides the reader with a quick overview of MRI for quick reference and examination preparation. As part of the Rad Tech''s Guide Series, this volume features an overview of anatomy, imaging tips, scanning procedures, and the latest information on protocols--all in the context of patient care and safety. Each book in the Rad Tech''s Guide Series covers the essential basics for those preparing for their certifying examinations and those already in practice.Table of Contents1 Patient Care and Safety for Magnetic Resonance Imaging 1 Introduction to Patient Care and Safety for MRI 3 Screening Patients and Personnel 3 Ancillary Equipment and Implants 8 Assessing and Monitoring 19 Contrast Agents for MRI 21 Life-Threatening Situations 24 Safety Precautions for Placement of Electrical Conductors 24 Environmental Considerations Temperature and Humidity 25 Gauss Line and Magnetic Field Strength 25 Emergency Procedures 27 Quench 27 Evacuation 29 Biologic Considerations 29 Radio Frequency Fields 29 Static Field Strength 32 FDA Guidelines for State Magnetic Fields 35 Gradient Magnetic Fields (Time-Varying Magnetic Fields) 35 Future Safety Considerations 38 2 Introduction to Clinical MRI Procedures 41 Introduction to Clinical MR. 41 Patient Preparation for Clinical: MRI 42 Special Considerations for Pediatric Patients 43 Choosing the Right Protocol 43 Parameters for Image Contrast in MRI 44 Pulse Sequences 47 Parameters for Signal-to-Noise and Resolution 51 Creating Artifact-Free Images 53 Types of FDA-Approved Contrast Agents 55 3 Imaging Procedures: Head and Neck Imaging. 57 Introduction of Head and Neck MRI 57 Standard Protocols for Imaging of the Brain 58 Anatomy and Physiology of the Brain 60 Patient Set-Up and Positioning for Brain Imaging 64 Indicators for Contrast Agents for Brain Imaging 65 Indicators for High-Resolution Brain Imaging 67 4 Spine Imaging Procedures 71 Introduction to Spine Magnetic Resonance Imaging 71 Standard Protocols for Imaging the Spine 72 Additional Spine Sequences for High Resolution 74 Anatomy and Physiology of the Spine 74 Patient Set-Up and Positioning for Spine Imaging 76 Indicators for Contrast Agents for Spine Imaging 79 Cervical Spine Imaging 80 Thoracic Spine Imaging 80 Lumber Spine Imaging 82 5 Musculoskeletal Imaging Procedures 85 Introduction to Musculoskeletal Magnetic Resonance Imaging 86 Standard Protocols for Imaging the Musculoskeletal System 86 Patient Set-Up and Positioning for Musculoskeletal Imaging 90 Indicators for Contrast for Musculoskeletal Imaging 92 Standard Dose and Administration for Gadolinium 92 Magnetic Resonance Imaging of the Temporomandibular joint 93 Magnetic Resonance Imaging of the Upper Extremities 94 Magnetic Resonance Imaging of the Lower Extremities 101 6 Thorax Imaging Procedures. 111 Introduction to Thorax Magnetic Resonance Imaging 111 Standard Protocols for Imaging the Thorax 112 Patient Set-Up and Positioning for Thorax Imaging 116 Indicators for Contrast Agents for Thorax Imaging 121 Magnetic Resonance Imaging of the Breast 123 7 Abdomen Imaging Procedures 131 Introduction to Abdomen Magnetic Resonance Imaging 131 Standard Protocols for Imaging the Abdomen 132 Anatomy and Physiology of the Abdomen 136 Patient Set-Up and Positioning for Abdomen Imaging 138 Indicators for Contrast Agents for Abdomen Imaging 140 8 Pelvis Imaging Procedures 143 Introduction to Pelvis Magnetic Resonance Imaging 143 Standard Protocols for Imaging the Pelvis 144 Patient Set-Up and Positioning for Pelvis Imaging 144 Indicators for Contrast Agents for Pelvis Imaging 146 Standard Dose and Administration for Gadolinium 147 Standard Protocols for Female Pelvis MRI 147 Standard Protocols for Male Pelvis MRI 152 9 Vascular Imaging Procedures 155 Introduction to Vascular Magnetic Resonance Imaging 156 Flow Imaging: An Overview 156 Magnetic Resonance Angiography: An Overview 158 Body Magnetic Resonance Angiography Changes 163 Anatomy and Physiology of the Vascular System 166

Read more less

Book SynopsisPharmacovigilance from A to Z is an authoritative text focusing on the common questions and procedures involved in prescribed-drug monitoring. The alphabetized format provides an easy-to-use reference, while a separate section of the book guides the reader logically from topic to topic to form related chapters.Table of ContentsForeword. Introduction. Abbreviations. A. B. C. D. E. F. G. H. I. JKL. M. N. O. PQ. R. S. T. U. V. W. XYZ.

Read more less

Book SynopsisHelps veterinary nurses with various types of calculations. This book includes numerous worked examples to develop the reader's confidence in carrying out the procedures involved. It enables the reader to progress from an explanation of the arithmetic principles involved, to the application of these principles to useful veterinary calculations.Trade Review"every veterinary practice should keep a copy in its library, so that the practice nurses can remind themselves of how to work out calculations in their day-to-day work. This is a very readable book and one that I unreservedly recommend.” Veterinary Nursing Table of ContentsPreface. Disclaimer. Common Abbreviations Used in Text. Units, Conversion Factors and Related Medical Abbreviations. Basic Principles. Changing the Concentration of a Solution. Calculating Energy Requirements. Dosages - Oral Route. Dosages - Injections. Rehydration of the Patient. Fluid Therapy - Rates of Administration. Anaesthetic Gases - Flow Rates. Radiography. Value Added Tax (VAT). Examination Techniques. Index

Read more less

Book SynopsisThis revision of a popular title gives an overview of internal medicine, highly relevant as a study and clinical aid. Complex material is distilled and organized in a logical, succinct and accessible way, with integration of clinical, laboratory/imaging and therapeutic information. Extensively re-written with the assistance of two new authors, each chapter has been carefully reviewed. Up-to-date and portable, this little book caters to day-to-day clinical decision making, while also targeting postgraduate examination preparation. Each body system is dealt with in a separate chapter, with additional chapters on pharmacology and best evidence. In addition, material is further organized into clinical clues, pathophysiology, diagnosis, and treatment. For medical students and junior doctors this is an important study aid and clinical reference. For allied health practitioners it is a straightforward reference, which can be used in the office or on the wards. For established practTrade Review"Money extremely well spent, I would recommend it to anyone trying to pass finals at the moment." (Sphincter, Liverpool Medical Students' Society Magazine) "This is an excellent pocket-sized edition, which will prove to be invaluable in revision for the membership examinations.... A useful reference book, both for learning and revision. It achieves what many MCQ books fail to deliver - the complete answer, not just the reason why a stem is correct..." (Barts and the London Chronicle, Autumn 2000) "...It is tight-lipped. It neatly summarises each field/subject. It uses tables and bulleted sentences. It fits neatly into a pocket. It tells you nothing that isn't essential. It's about internal medicine. It does exactly what is says on the cover." (Black Bag - Bristol Medical School Gazette, 2000)Table of ContentsPreface. Acknowledgements. Abbreviations. 1 Epidemiology, sSatistics and Evaluation of the Literature. 2 Pharmacology. 3 Cardiology. 4 Respiratory Medicine. 5 Gastroenterology. 6 Hepatology. 7 Nephrology. 8 Neurology. 9 Endocrinology. 10 Haematology. 11 Oncology and palliative medicine. 12 Immunology and allergy. 13 Rheumatology. 14 Infectious diseases. 15 Medical dermatology. 16 Psychiatry. Index.

Read more less

Book SynopsisBotulinum toxin A is a remarkably versatile treatment with a steadily expanding list of indications, which include strabismus, hemifacial spasm, focal dystonias such as spasmodic torticollis, dysphonia and writer's cramp, as well as adult and childhood spasticity.Trade Review"...a comprehensive and succinct overview..." Hospital Update "...an essential companion..." JNNP "...a valuable tool...recommended..." Neuro-ophthalmologyTable of ContentsPART ONE: General. Chp 1. History and current applications of botulinum toxin *Moore & Naumann. Chp 2. The molecular basis of the activity of botulinum toxin. *Montecucco & Rosetto. Chp 3. General and clinical aspects of treatment with botulinum toxin. *Moore & Naumann. Chp 4. EMG and Imaging. *Poewe and Wissel. PART TWO: Disorders of Movement. Chp 5. Dystonia. *Brin. 5.1 Cranio-facial dystonia. *Brin. 5.2 Laryngeal and pharyngeal dystonia. *Blitzer, Sulica & Verhayden. 5.3 Cervial and axial (spinal) dystonia. *Benecke. 5.4 Limb and occupational dystonia (including non limb variants). *Sheean. Chp 6. Spasticity in adults: Introduction. *Gracies & Simpson. 6.1 Upper limbs and neck. *Gracies & Simpson. 6.2 Lower limbs. *Hefter. Chp. 7 Spasticity in children. *Graham, Heinen & Berweck. Chp 8. Other involuntary muscle activity - Tremor. *Findlay & Senanayake. Chp 9. Exotic movement disorder indications. *Jankowic & M Thomas. PART THREE: Autonomic Disorders. Chp 10. Disorders of secretion. *Naumann. Chp 11. Pelvic floor and gastrointestinal uses. *Jost. PART FOUR: Other Indications. Chp 12. Ophthalmic. *Lee. Chp 13. Pain. *Nurmikko. Chp 14. Cosmetic Use. *Lowe & Sommer. Chp 15. The future of neurotoxins. *Moore & Naumann

Read more less

Book SynopsisEdited by an orthopaedic surgeon and a haematologist who are leading specialists in the treatment of haemophilia, Inhibitors in Patients with Haemophilia reviews the different haemostatic products and protocols for the control of bleeding and surgery in haemophilic patients with inhibitors. The book draws together in a single volume all of the clinical issues involved in the treatment of inhibitors from numerous specialists worldwide. It will be an invaluable resource for all those treating inhibitors in people with haemophilia.Table of ContentsContributors. Preface. HAEMATOLOGY. 1 Natural history of inhibitor in severe haemophilia A and B: incidence and prevalence. Jeanne Lusher (USA). 2 Characterisation of inhibitors in congenital haemophilia. Kathelijne Peerlinck and Marc Jacquemin (Belgium). 3 Incidence and prevalence of inhibitors and type of blood product in haemophilia A. Christine Lee and Thynn Thynn Yee (UK). 4 Genetic basis of inhibitor development in severe haemophilia A and B. Edward Tuddenham (UK) and Johannes Oldenburg (Germany). . MANAGEMENT OF TREATMENT. 5 Therapeutic products: human FVIII, porcine FVIII, prothrombin complex concentrates, activated prothrombin complex concentrates and recombinant FVIIa. Thierry Lambert (France). 6 Methods: plasmapheresis and protein A immuno-adsorption. Eric Berntorp (Sweden). 7 Venous access in children with inhibitors. Rolf Ljund (Sweden). IMMUNETOLERANCE. 8 Immunetolerance: high dose regimen. Hans Brackmann and Thomas Wallny (Germany) (To be agreed). 9 Immunetolerance: low dose regimen. Eveline Mauser-Bunschotten (Netherlands). 10 Immunotolerance and choice of concentrates. Wolfgang Kreutz (Germany). 11 Immunetolerance regimen: the North America registry (To be agreed). Donna DiMichele (USA). . MEDICAL MANAGEMENT OF BLEEDING EPISODES. 12 Treatment of bleeding episodes in children. Joan Tusell (Spain). 13 General medical management of bleeding episodes: haemarthroses, muscle haematoma, mucocutaneous bleed, haematuria. Manuel Quintana (Spain). 14 Life- and limb-threatening bleeding episodes and intracranial bleeds. Sam Schulman (Sweden). . INHIBITORS IN HAEMOPHILIA B. 15 Inhibitors in haemophilia B patients. India Warrier (USA). 16 Inhibitors in mild/moderate haemophilia. Charles Hay (UK). 17 Acquired inhibitors to FVIII. Craig Kessler (USA). . MUSCULOSKELETAL ISSUES. 18 Pathogenesis of musculoskeletal complications of haemophilia. E C Rodriguez-Merchan (Spain). 19 Orthopaedic management of haemarthroses. E C Rodriguez-Merchan (Spain). 20 Synoviorthesis with Rifampicin. Horacio Caviglia (Argentina) and F Fernandez-Palazzi (Venezuela). 21 Radiosynoviorthesis. Eric Berntorp (Sweden). 22 Musculoskeletal MRI. Rachel Nuss and Jerome Wiedel (USA). 23 Iliopsoas haematomas and limb compartment syndromes. Michael Heim (Israel). 24 Pseudotumours. Marvin Gilbert (USA). 25 Haemophilia patients with inhibitors: a rheumatologist´s point of view. John York (Australia). 26 Rehabilitation. Felipe Querol and José Aznar (Spain). 27 Physiotherapy. Karen Beeton (UK). 28 Elective orthopaedic surgery in patients with high responding inhibitors-. Ivan Hvid, J Soballe and J Ingerslev (Denmark). . GENERAL SURGERY. 29 General and emergency surgery in patients with high responding inhibitors. Owen Smith & Barry White (Ireland). 30 Dental extractions. Uri Martinowitz (Israel). . PSYCHOSOCIAL ISSUES. 31 Psychological issues. Pilar Arranz (Spain). . 32 GENERAL STRATEGY FOR MANAGEMENT OF INHIBITOR PATIENTS. Inga Scharrer (Germany). Index

Read more less

Book SynopsisMedicine and Surgery is an exciting new book that contains the core information needed by medical students in the run up to exams. This is the only book available that covers both medicine and surgery. It encompasses all of the major systems and core subjects Every condition is discussed under the key headings of definition, epidemiology, aetiology, pathophysiology, clinical features, investigations, management and prognosis The content follows a very consistent and familiar style, so that information is easily accessible, digestible and memorable Each chapter opens with an overview of clinical method before discussing the most common conditions relevant to that speciality Medicine and Surgery: A Concise Textbook is written specifically for medical students as essential revision preparation, for junior doctors as a refresher on the wards and for other allied health professionals who want a quick remindTrade Review''I like the way the book goes through each disease using the same system of definition, aetiology etc. This makes it easier to learn….The content is exactly what the undergraduate brain needs” Final year student, University of OxfordTable of Contents1 Principles and Practice of Medicine and Surgery. 2 Cardiovascular System. 3 Respiratory System. 4 Gastrointestinal System. 5 Hepatic, Biliary & Pancreatic Systems. 6 Genitourinary Systems. 7 Nervous System. 8 Musculoskeletal System. 9Dermatology & Soft Tissues. 10 Breast Disorders. 11Endocrine System. 12 Haematological System. 13 Nutritional and Metabolic Disorders. 14 Genetic Syndromes. 15 Overdose, Poisoning and Addictions. Index

Read more less

Book SynopsisWith contributions from over 100 leading authorities within the fields of exercise physiology, clinical internal medicine, sports medicine and traumatology, this book offers comprehensive coverage of both basic science and clinical aspects of sports injury and physical activity.Trade Review"This book is a welcome addition to the field of sports medicine and nicely covers a wide range of topics. It provides up-to-date, practical, and theoretical information for those who study or take care of active populations. Busy clinicians will find this to be a helpful reference that they routinely consult."(Scott Paluska, MD, @Doody's Review Service)Table of ContentsSection 1: Basic science of physical activity and sports injuries - Principles of training. 1.1 Cardiovascular and respiratory adaptation to physical training. 1.2 Metabolism during exercise - energy expenditure, hormonal changes. 1.3 Skeletal muscle: physiology, training and repair after injury. 1.4 Neuromuscular aspects and joint neurophysiology in exercise - adaptive responses evoked by strength training. 1.5 Biomechanics of locomotion. 1.6 Connective tissue in ligaments, tendon and muscle: physiology and repair, and musculoskeletal flexibility 1.7 Cartilage tissue - loading and overloading. 1.8 Bone tissue -training and injury. Section 2: Aspects of human performance. 2.1 Recovery after training - inflammation, metabolism, and tissue repair, overtraining. 2.2 Principles of Rehabilitation following sports injuries. 2.3 Physical activity and environment. 2.4 Nutrition and fluid intake with training. 2.5 Ergogenic aids (doping) and pharmacological injury treatment. Section 3: Physical achievements vs sports injury. 3.1 Epidemiology and prevention of sports injuries. 3.2 Exercise as disease prevention. 3.3 Physical activity in the elderly. 3.4 Exercise in healthy children and in those who have a chronic disease. 3.5 Disabled individuals and exercise. Section 4: Exercise in acute and chronic medical diseases. 4.1 Athletes' heart - cardiovascular and peripheral vessel diseases. 4.2 Exercise and infectious diseases. 4.3 Osteoarthritis. 4.4 Exercise in the treatment of type 2 and 1 diabetes. 4.5 Asthma and chronic airway disease. 4.6 Amenorrhea, osteoporosis, and eating disorders in athletes. 4.7 Physical Activity and obesity. 4.8 Exercise in acute snd chronic medical conditions: gastrointestinal considerations. Section 5: Imaging in Sports Injuries. 5.1 Imaging in Sports Injuries. Section 6: Regional considerations. 6.1 Lower leg, ankle and foot. 6.2 Knee. 6.3 Athletic injuries to the hip, groin and pelvis. 6.4 Head injuries. 6.5 Spine. 6.6 Shoulder. 6.7 Elbow, wrist and hand. 6.8 Practical sports and medicine

Read more less

Book SynopsisSports concussions make headlines, but you don't have to be an NFL star to suffer traumatic brain injury. In Shaken Brain, Elizabeth Sandel, MD, shares stories and research from her decades treating and studying brain injuries. She explains what concussions do to our bodies, how to avoid them, and how to recover.Trade ReviewA fascinating page turner. Propelled by Dr. Sandel’s exceptional storytelling and clinical expertise, Shaken Brain sheds light on the myths and misunderstandings surrounding concussions, and their consequential impact on so many lives. -- Marilyn Spivack, cofounder and past President, Brain Injury Association of AmericaA thoroughly engaging and enlightening account, this book explores the often perplexing issues and controversies surrounding post-concussion symptoms. A vital read. -- Mel Glenn, MD, Spaulding Rehabilitation NetworkI was a doctor in 2002 when I suffered a traumatic brain injury. Even in my position, it was difficult to find information about post-concussive consequences and care. Shaken Brain fills in the gaps. Uniting clinical research, scientific data, and personal stories, this crucial resource is one that both physicians and their patients can look to for answers. -- Cheryle Sullivan, MD, author of Brain Injury Survival KitThe first step to improving concussion care is improving concussion education. Whether you’re an athlete, a parent, a medical professional, or none of the above, having the proper knowledge about what a concussion is and what to do when one is sustained can often be the difference between a quick recovery and a lengthy one. A book like Shaken Brain offers needed information. -- Brittni Souder, former soccer player and Board Member, PINK ConcussionsShaken Brain is frank, accessible, and authoritative—a crucial tool for sharing medical knowledge. Read this book if you are a traumatic brain injury survivor, a clinician, a family member, or simply interested in learning more about brain health. -- David Cifu, MD, Virginia Commonwealth University School of Medicine and the US Department of Veterans AffairsA physician with over 25 years’ experience studying and treating concussion details what happens in the human brain when it is injured, and how medical providers can help…Emphasizing that it isn’t just athletes who need to worry, Sandel examines the high incidence of concussion among certain vulnerable populations, including the very young, elderly, homeless or impoverished, and victims of child abuse or domestic violence. To that end, she looks at prevention as a public health issue…Her expertly presented and researched work will be invaluable for anyone concerned about concussions. * Publishers Weekly *I recommend Shaken Brain to anyone interested in a deeper, nuanced understanding of concussion/mild TBI. Dr. Sandel effortlessly conveys the information typically found in a textbook with the ease and style of a novelist. It is a valuable resource for patients who have experienced concussion and their families, as well as for the physicians, therapists, and scientists who have made it their life’s work to help them. -- John Leddy * Brain Injury *

Read more less

Book SynopsisIn the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. This title traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell 'mild' in a social setting.Trade ReviewWinner of the 2014 Robert B. Textor and Family Prize for Excellence in Anticipatory Anthropology, American Anthropological Association Winner of the 2011 Amaury Talbot Prize for African Anthropology, Royal Anthropological Institute "Duana Fullwiley has produced an extraordinary work that incorporates the insights of anthropology as well as science and technology studies of genetics and race. It is also exceptional in its multi-sited focus on Senegal and France, since many similar studies of genetics have tended to focus on the US and Europe."--Elisha P. Renne, Anthropological Quarterly "The Enculturated Gene is the product of over ten years of research beginning in the late 1990s. The book is stunning in its scope and attention to a full range of issues, from discoveries in the lab to knowledge production in the clinic to global health responses... By elucidating ethnographically the contingencies that have produced the local and global health responses to sickle cell disease, Fullwiley shows us that health policy is as much a product of culture and subjectivity as affective responses to physical and existential pain."--Carolyn Rouse, Medical Anthropology QuarterlyTable of ContentsList of Illustrations viii Preface ix Acknowledgments xxv Chapter One: Introduction: The Powers of Association 1 Chapter Two: Healthy Sicklers with "Mild" Disease: Local Illness Aff ects and Population- Level Eff ects 45 Chapter Three: The Biosocial Politics of Plants and People 77 Chapter Four: Attitudes of Care 119 Chapter Five: Localized Biologies: Mapping Race and Sickle Cell Difference in French West Africa 158 Chapter Six: Ordering Illness: Heterozygous "Trait" Suff ering in the Land of the Mild Disease 197 Chapter Seven: The Work of Patient Advocacy 221 Conclusion: Economic and Health Futures amid Hope and Despair 250 Notes 275 References 307 Index 329

Read more less

Book SynopsisTrade Review"Winner of the 2018 Don K. Price Award, Science, Technology & Environmental Politics Section of the American Political Science Association""Winner of the 2018 Louis Brownlow Book Award, National Academy of Public Administration""Persuasive."---Carey Goldberg, WBUR's CommonHealth blog"The United States stands out among rich countries in resisting evidence-based medicine--not in theory, perhaps, but in practice. In this informative book, the authors, all political scientists, document this phenomenon and then consider why ordinary people, physicians, and politicians all resist public spending on research that would produce obvious benefits for everyone."---Richard N. Cooper, Foreign Affairs"Unhealthy Politics connects the dots in the complex relationships among physicians, medical societies, the public, and politicians. . . . Unhealthy Politics, in the end, is most convincing in describing the limited extent to which evidence can guide the activities of key actors. The irony is this: For those who wish to see evidence-based medicine implemented, more and better medical evidence might not be the answer. Rather, we need better evidence about how to implement what we already know."---Romana Hasnain-Wynia, Health Affairs"A remarkable example of the contribution that political science has to make to discussions of policy problems that have chiefly concerned other fields . . . . Patashnik, Gerber, and Dowling bring to bear not only a wealth of original survey evidence . . . but also a wealth of theoretical insights from the policy process and legislative politics literatures." * Journal of Politics *

Read more less

Book SynopsisThis enlightening and individualistic narrative traces the development of the BMA from its inception, through two world wars and the advent of the NHS

Read more less

Book SynopsisCovering both the pharmacological and the more controversial non-pharmacological management of pain relief, this comprehensive text, edited by an internationally renowned specialist, provides practical guidance to all involved in this aspect of labour care.

Read more less

Book SynopsisReviews various aspects of the investigation of neurological disease. This book features topics including: Neuropsychological assessment; Vision; Visual loss; Eye movements; Disorders of balance; Peripheral neuropathy; and, Muscle disease. It is intended as a reference for neurologists, neurosurgeons, and psychiatrists.Table of ContentsContributors; Introdution, R.A.C Hughes; Electroencephalography, C.D. Binnie, P.F. Prior; Imagining the head: the brain, Dr I. Mosley; Imagining the head: blood vessels, Dr. R. Sellar; Imagining the head: PET, Dr G.V. Sawle; Imagining the spinal cord, Dr J.M. Stevens; Intracranial pressure, Professor J.D. Pickard; Cerebrospinal fluid, Dr E.J. Thompson; Encephalography, Dr C. Binnie; Neuropsychological testing, Professor E. Warrington; Neuro-ophthalmology - visual disorders, Mr. M. Sanders; Neurotology, including eye movement disorders, Professor C. Kennard; Vestibulocerebellar abnormality, Dr A. Bronstein, Dr P. Rudege; Investigating peripheral neuropathy, Professor J.G. McLeod; Investigating muscle disease, Dr B.R.F. Lecky; Neurogenic bladder, Dr. C. Fowler; Metabolic disorders, Dr P.D. Swanson; Cerebrospinal fluid, E.J. Thompson; Multimodalmonitoring in neurointensive care, P.J. Kirkpatrick, M. Czosnyka, J.D. Pickard; Index

Read more less

Book SynopsisThis third, fully revised edition, brings the reader up to date with recent advances made in the study of disease at the molecular and cellular level, and examines the new possibilities for treatment. Subjects covered include methods used in molecular medicine and the polymerase chain reaction.Table of ContentsMolecular and cell biology in clinical medicine; methods in molecular medicine; the polymerase chain reaction - a tool for molecular medicine; an introduction to cells; stem cells in normal growth and disease; cell reproduction; apoptosis (programmed cell death); cell to cell and cell to matrix adhesion; how do receptors at the cell surface transmit signals to the cell interior?; membrane traffic, from cell to clinic; cytoskeleton and disease; the cell nucleus' gene regulation and transcription factors; genes and cancer; human congenital malformations - insights from molecular genetics; molecular genetics of common diseases; impact of molecular biology on clinical genetics; monoclonal antibodies in medicine; production and use of therapeutic agents; gene therapy.

Read more less

Book SynopsisTransport affects everyone - it enables access to social activities, employment, leisure, goods, and services. This report highlights the various ways in which transport policy affects health, considering not the more obvious effects but also other consequences of transport policy. It is for students, policy makers, town planners, and doctors.Table of ContentsIntroduction. Patterns of transport use in Great Britain. The health benefits of road transport policy. The health impact of road transport. Reducing health risks and increasing health benefits through transport policy. Towards road transport and health. References. Index.

Read more less

Book SynopsisA book which discusses the role of narrative in medicine from various angles, covering both theoretical and practical aspects. It includes real examples of patients' narratives, the use of narrative as a therapeutic tool, teaching narrative to students and the narrative medical record. It is aimed at General Practitioners and medical educators.Trade Review"Add NBM to your EBM and discard your medical mythology" - Journal of the Royal Society of MedicineTable of ContentsIntroduction. 1.Why study narrative?. 2.Turtles all the way down. Illness stories. 3.Themedian isn't the message. 4.The night my life changed. 5.The good bleed guide. 6.Stories of dying. 7.Have i got epilepsy or has it got me?. Filler: the conker tree. Narrative in medicine. 8.Pain narratives. 9.Following hte story: continuity of care in general practice. 10.Narrative and mental health. 11.Sirens, stray dogs and the narrative of hilda thomson. 12.The surgeon's narrative. Filler: pressuring mrs thomas to accept her treatment. Learning and teaching narrative. 13.Literature in medicine. 14.Teaching humanities in the undergraduate medical curriculum. 15.The golden narrative in british medicine. 16.Nursing, narrative and the moral imagination. Filler: Upwardly mobile. Understanding narrative in health care. 17.Stories that we hear and stories we tell. 18.Narrative in psychotherapy. 19.The narrative in medical record. 20.Anecdote in clinical practice. Filler: Dead notes. Broader perspectives on narrative in health care. 21.Narrative in medical ethics. 22.Cross cultural medical narratives: some case studies from latvia and siberia. 23.The narrative stream in medical negligence. 24.Narrative based medicine in an evidence based world. Filler: Dear tom

Read more less

Book SynopsisA comprehensive text from the leading transplant centres on the medical management of thoracic organ transplantation, covering the assessment of patients for possible transplantation, through to managing patients after transplantation including any possible complications and shared care aspects of long term managementTable of ContentsIdentification of the suitable heart transplant recipient. Identification of the suitable lung transplant recipient. Medical management of the potential donor. Cardiac transplantation. Choice of procedure and early post-operative management of the lung transplant recipient. Microbiology aspects of heart and heart-lung transplantation. Histopathology of heart and lung transplantation. General management of the heart transplant recipient. Cardiac complications following cardiac transplantation. General management of the lung recipient including aspects of postoperative shared care

Read more less

Book SynopsisThe aim of this work is to reduce the risks of medical treatment and enhance the safety of patients in all areas of healthcare. The first section discusses the incidence of harm to patients, while other sections examine features of the healthcare systems that are essential to safe practice.Trade Review"Recommended for all in health care because safety has always been an issue." (Eye News, 2011) "Therefore I believe that this book should be read by anyone involved in, or responsible for healthcare . . . This makes a compelling case to benefit from the safety and quality improvement approaches described in the book." (The Bulletin of the Royal College of Pathologists, 1 July 2011)Table of ContentsUnderstanding adverse events. Errors and adverse events in medicine. The development of risk management. Clinical governance. Reducing risks in obstetrics. Reducing risks in paediatrics. Risk management in anaesthesia. Risk management in surgery. Risk management in A&E medicine. Reducing risks in hospital general medicine. Risk management in clinical oncology. Risk management in psychiatry. Risk management in general practice. Communicating risk. Guidelines and pathways. The role of human factors engineering. Working time, stress and fatigue. Training and supervision. Teams, culture and managing risk. Creating and maintaining safe systems. Impementation of risk management. Clinical incident reporting. Investigation and analysis of adverse events. Caring for patients harmed by treatment. Supporting staff. Dealing with complaints. Resolving disputes. Claims management

Read more less

Book SynopsisThe first sustained UK textbook devoted to the newly-emerging Medical Humanities Focusing on the human experiences at the heart of medical care, health, illness, disability and suffering Exploring aspects of clinical medicine which are not captured by natural sciences Integrating a range of contributing humanities disciplines.Table of ContentsSection 1: Humanities Reflecting Society. The nature and role of the medical humanities. Society, community, well being. Evaluating the outcome of arts and health initiatives. Medical record as catalogues of experience. Section 2: Patients and Professionals. The consultation as Rubik's cube. The new genetics - re-telling and re-interpreting an old story. Poetry as a key for healthcare. Spirituality as an integral part of care. Section 3: Changing Attitudes. Portfolio learning. Creative arts in the medical curriculum. Memorials. Why medical humanities now?. Medical humanities - means, ends and evaluation. Section 4: Understanding Medical Knowledge. Validating the facts of experience in medicine. The humanities role. Philosophy's gaze

Read more less

Book SynopsisThis book provides a practical set of rules to guide and help trainee obstetricians and midwives to understand the concepts of labour ward management, treatments, and prevention of complications. Labour ward management is a vital tool in learning to secure safe outcomes for both mothers and babies.Table of ContentsIntroduction. Stages of Labour. Fetal Monitoring. Induction of Labour. Operative Deliveries. Complex Deliveries. - Breech Deliveries. - Twin Deliveries. - Shoulder Dystocia. - Preterm Deliveries. Obstetric Haemorrhage and Shock. Infection. Hypertension. Postnatal Problems. Conclusions

Read more less

Book SynopsisThis is a workbook for health professionals working with diabetic patients. It is based on the experiences of one group of health care workers in an inner city area. It illustrates how using individual patients'' stories can inform and help health care workers to understand and manage their patients'' difficulties better. In this way it has similar aims to the narrative based medicine books. It also provides the interactive learning element with suggested learning objectives, assignments and further reading in each unit.Table of ContentsAcknowledgements. Introduction. About this workbook. About the Diabetes Sharing Stories Project. About storytelling. About learning in groups. Group work objectives. Unit 1 Learning about diabetes care - where should we start?. Unit 2 The diagnosis of diabetes. Unit 3 Diabetes in the family. Unit 4 Check-ups and visits to the doctor. Unit 5 Medication. Unit 6 Supporting positive lifestyle choices. Unit 7 Loneliness and lack of support. Unit 8 Communicating across cultures. Unit 9 Educating and supporting other health professionals. Unit 10 Diabetes and women's health. Appendix: Template for writing up a story. Index.

Read more less

Book SynopsisGeneral practitioners and other primary care professionals have a leading role in contemporary health care, which Trisha Greenhalgh explores in this highly praised new text.Trade Review"Trish Greenhalgh is one of the international stars of general practice and a very clever thinker. This new book is a wonderful new resource for primary health care and general practice. Every general practice registrar should read this book and so should every general practice teacher and every primary care researcher."—Professor Michael Kidd, Head of the Department of General Practice, The University of Sydney and Immediate Past President of The Royal Australian College of General Practitioners "General practice in the U.K. is responsible for more patient care than ever before, and its input to medical training and research is at an all-time high. But its broadening roles and changing political context are at risk of causing an identity crisis. We are fortunate that Professor Trish Greenhalgh has brought her passion, intelligence and scholarship to bear on one of the key questions for health professionals today - what is the best of primary care about, and why is it essential for patients and doctors? She encourages debate while supporting and inspiring primary care, because she tells a modern story of a discipline whose purpose is valuable and which can rise to its new challenges. I am personally very glad to have read this timely and exciting book."—Amanda Howe, MA MD MEd FRCGP ILT(M), Professor of Primary Care & MB/BS Course Director Institute of Health University of East Anglia Norwich NR4 7TJ Norfolk "This book meets a real need for a lively, engaging and perceptive book that brings together the population with the individual perspective and describes the key concepts that underpin contemporary primary care with admirable clarity. This book deserves to become a classic and will be welcomed by enquiring undergraduates and postgraduates alike who want a book that will both challenge and inform."—Professor Andy Haines, Director, London School of Hygiene & Tropical Medicine, London, UK "This important new book by one of primary care's most accomplished authors sets out clearly the academic basis for further developments in primary health care. Health systems will only function effectively if they recognise the importance of high quality primary care so I strongly recommend this book to students, teachers, researchers, practitioners and policy makers."—Professor Martin Marshall, Deputy Chief Medical Officer, Department of HealthTable of ContentsAcknowledgements. Preface. Foreword. 1 Introduction. 1.1 What is primary (health) care? 1.2 What is academic study?. 1.3 What are theories – and why do we need them? 2 The 'ologies' (underpinning academic disciplines) of primary health care. 2.1 Biomedical sciences. 2.2 Epidemiology. 2.3 Psychology. 2.4 Sociology. 2.5 Anthropology. 2.6 Literary theory. 2.7 Philosophy and ethics. 2.8 Pedagogy. 3 Research methods for primary health care. 3.1 What is good research in primary health care? 3.2 Qualitative research. 3.3 Quantitative research. 3.4 Questionnaire research. 3.5 Participatory ('action') research. 3.6 Research data – and analysing it. 3.7 Critical appraisal of published research papers. 3.8 Systematic review. 3.9 Multi-level approaches to primary care problems. 4 The person who is ill. 4.1 The sick role. 4.2 The illness narrative. 4.3 Lifestyle choices and 'changing behaviour'. 4.4 Self-management. 4.5 Health literacy. 5 The primary care clinician. 5.1 The role of the generalist. 5.2 Clinical method I: rationalism and Bayes' theorem. 5.3 Clinical method II: humanism and intuition. 5.4 Clinical method III: the patient-centred method. 5.5 Influencing clinicians’ behaviour. 5.6 The ‘good’ clinician. 6 The clinical interaction. 6.1 The clinical interaction I: a psychological perspective. 6.2 The clinical interaction II: a sociolinguistic perspective. 6.3 The clinical interaction III: a psychodynamic perspective. 6.4 The clinical interaction IV: a literary perspective. 6.5 The interpreted consultation. 7 The family – or lack of one. 7.1 Family structure in the late modern world. 7.2 The mother–child relationship (or will any significant other do these days?) 7.3 Illness in the family – nature, nurture and culture. 7.4 Homelessness. 8 The population. 8.1 Describing disease in populations. 8.2 Explaining the ‘causes’ of disease. 8.3 Detecting disease in populations. 8.4 'Risk': an epidemiological can of worms? 9 The community. 9.1 Unpacking health inequalities I: deprivation. 9.2 Unpacking health inequalities II: social networks and social capital. 9.3 Unpacking health inequalities III: life course epidemiology and 'risk regulators'. 9.4 Developing healthy communities I: community oriented primary care. 9.5 Developing healthy communities II: participatory approaches. 10 Complex problems in a complex system. 10.1 Illness in the twenty-first century: chronicity, comorbidity and the need for coordination. 10.2 Coordinating care across professional and organisational boundaries. 10.3 The electronic patient record: a road map for seamless care? 10.4 The end of an era? 11 Quality. 11.1 Defining and measuring quality. 11.2 A rational biomedical perspective: evidence-based targets, planned change and criterion-based audit. 11.3 A narrative perspective: significant event audit. 11.4 A social learning perspective: peer review groups and quality circles. 11.5 A phenomenological perspective: the patient as mystery shopper. 11.6 A sociological perspective: Quality Team Development as organisational sensemaking. Index

Read more less

Book SynopsisExplores the intellectual basis of narrative in medicine. This book provides an interface between evidence based and patient centred medicine.Table of Contents1. The ethicality of narrative medicine. 2. Soldiers become casualties: doctor's accounts of the SARS epidemic. 3. Poems from the heart: living with heart failure. 4. performance narratives in the clinical world. 5. "I cut because it helps": narratives of self injury. 6. The DIPex project: collecting personal experiences. 7. Narratives of spirituality and religion in the end-of-life care. 8. The death of the narrator. 9. Narrative, emotion and understanding. 10. The voice of experience and the voice of the expert - can they speak to each other?. 11. Wounded or warrior? Stories of being or becoming deaf. 12. Narrative analysis and contested allogations of Munchausen syndrome by proxy. 13. Confounding the experts: the vindication of parental testimony in shaken baby syndrome. 14. Narratives of compound loss: parents' stories from the organ retention scandal. 15. The power of stories over statistics: lessons form neonatal jaundice and infant airplane safety. 16. Narratives of health inequality: interpreting the determinants of health. 17. Narratives of displacement and identity. 18. A thrice-told tale: new readings of an old story. 19. The role of stories and storytelling in organisational change efforts: a field study of an emerging "community of practice" within the UK National Health Service. 20. Meta-narrative mapping: a new approach to the systematic review of complex evidence. 21. How narratives work in psychiatric science: an example from the biological psychiatry of PTSD. 22. Storytelling policy: constructions of risk in proposals to reform UK mental health legislation. 23. The temporal construction of medical narratives

Read more less

Book SynopsisBrings you up to speed on recognising the symptoms of serious illnesses. This book provides information on diagnosis and action. It answers the express need of doctors to avoid making diagnostic errors.Trade Review"A must have [that] will surely come in handy, even if it saves just one patients life in the future.... Overall grade/score: 5/5." (Leicester Scrubs, January 2010) "This is a valuable and well-edited collection of potentially serious speciality-specific symptoms. It is highly informative and should alert the reader to the 'alarm bells' that may present in their clinical practice. The book should prove a valuable asset to the library of anyone involved in the practice of medicine including medical students, GPs and hospital doctors." (Annals Royal College of Surgeons of England, 2006)Table of ContentsList of contributors. Introduction. Acknowledgement. Abbreviations. Breast surgery. Cardiology. Cardiothoracic surgery. Care of the elderly. Dermatology. Endocrinology. ENT. Gastroenterology and colorectal surgery. Genito-urinary medicine. Gynaecology. Haematology. Heptology and hepatobiliary surgery. HIV medicine. Immunology. Metabolic medicine. Neurology. Neurosurgery. Obstetrics. Oncology. Ophthalmology. Oral and maxillofacial surgery. Orthopaedics. Paediatrics. Paediatric surgery. Plastic surgery. Psychiatry. Renal medicine. Respiratory medicine. Rheumatology. Transplantation. Upper GI surgery. Urology. Vascular surgery. Index

Read more less

Book SynopsisA detailed guide to the clinical trial process Content designed in consultation with doctors and patients who have taken part in trials Helps workers to discuss the pros and cons of participation with patients Allows patients to make well-informed decisions on whether to take part in a clinical trial.Table of ContentsChapter 1 Overview and Purpose of this Guide to Clinical Trials in the NHS. Overview and purpose of this guide. Who should use this guide to clinical trials in the NHS?. Chapter 2 Clinical Trials Explained. What are clinical trials?. Why are clinical trials needed?. Who is involved in a clinical trial?. How are clinical trials designed and approved?. Progression of a medical intervention through the clinical trial phases. Summary. Chapter 3 Clinical Trial Approval, Regulation and Funding. How are clinical trials approved and regulated?. Ethical approval. Informed consent. How are trials managed?. Who pays for a clinical trial?. Summary. Chapter 4 Understanding Clinical Trial Design and Results. Understanding randomisation and blinding in clinical trials. Understanding controls and placebos. Why are placebos used in clinical trials?. What about trials that are not controlled or blinded?. Understanding clinical trial results. Summary. Chapter 5 Questions About Clinical Trials: A Framework for Discussion. What are patients’ rights?. Why do patients take part in clinical trials?. Why do patients decline to take part in a clinical trial or withdraw from a clinical trial they are involved in?. How can patients be empowered during their involvement in a. clinical trial?. Will patients involved in clinical trials need extra help and support from. their carers?. What are the likely costs of and reimbursement for patients participating. in clinical trials?. Summary. Appendix A Finding Out About Clinical Trials that are Currently or Soon to be Recruiting. Appendix B ECRI Evidence Report: Patients’ Reasons for Participation in Clinical Trials and Effect of Trial Participation on Patient Outcomes. Glossary. Index

Read more less

Book Synopsis* A thoughtful and insightful textbook introduction to how health policy is made. * Pays attention to the social and political processes which structure what decisions are taken about health policy.Trade Review"This readable and accessible book provides many novel insights into the policy-making process, a broad span of well-chosen historical and contemporary health examples, and a range of perspectives to consider in relation to the analysis of health policy making."Health Sociology Review"This introductory text offers a novel approach to health policy making, challenging the conception of policy as a rational process. Written in an accessible style it is essential reading for undergraduate students of health policy."Jonathan Gabe, Royal Holloway, University of London "This book should be essential reading for any student interested in engaging with and critically reflecting on how health policy is shaped in contemporary society. Drawing on well chosen historical and contemporary examples, Making Health Policy engages with the complex, contingent, and contested arena of health policy making. Students will find the valuable insights provided in this book enormously useful in understanding contemporary and ongoing debates around the fashioning of health policy."Nick Emmel, University of Leeds "Alaszewski and Brown's historical reach and deep understanding of health policy going back 30 years makes this a highly readable, original, insightful and well-informed study that also manages to be remarkably up-to-date. Recommended reading for everyone interested in how health policy gets made and why it doesn't always happen as intended."David J. Hunter, Durham UniversityTable of ContentsPreface Introduction 1. What is health policy? Part 1 Rationality in policy making 2. Trying to achieve rational health policy: the search for appropriate knowledge and expertise 3. The competition for money and the limits of instrumental rationality 4. Power and influence in policy making: Policy communities and networks 5. The pressure of events: Disasters, inquiries and the dynamics of blame Part 2 The limits of rationality in policy making 6. Identifying health and social problems: Competition between interest groups and claims making 7. How does the nature of modern democracy shape the formation of health policy? 8. Ideology and policy: legitimating, bounding and framing 9. The impact of the media on health policy making Part 3 Conclusion 10. So how and why are health policies made? Some final comments References

Read more less

Book SynopsisSteadily increasing numbers of Americans have been diagnosed with asthma in recent years, attracting the attention of biomedical researchers, including those searching for a genetic link to the disease. The high rate of asthma among African American children has made race significant to this search for genetic predisposition. One of the primary sites for this research today is Barbados. The Caribbean nation is considered optimal because of its predominantly black population. At the same time, the government of Barbados has promoted the country for such research in an attempt to take part in the biomedical future.In Biomedical Ambiguity, Ian Whitmarsh describes how he followed a team of genetic researchers to Barbados, where he did fieldwork among not only the researchers but also government officials, medical professionals, and the families being tested. Whitmarsh reveals how state officials and medical professionals make the international biomedical research part of state caTrade ReviewWhitmarsh's investigation compels a rethinking of the biomedical stabilization of race and of enigmatic illnesses like asthma. His insight into the process by which race, genes, and environmental factors are negotiated in the Caribbean at the request of large corporations and scientific research teams is important. It will help the reader understand how such ideas, practices, and drugs are being marketed worldwide. -- Malcolm N. Blumenthal, MD * New England Journal of Medicine *

Read more less

Book SynopsisWhen Your Spouse Has a Stroke will relieve your burden and strengthen your partnership.Trade ReviewThis book is unique and clearly needed by many families of stroke survivors. -- Andreas R. Luft CardioPulse This book is a treasure that each caregiving spouse can mine for helpful suggestions and better ways of handling the kinds of issues we all face. -- Sandra M. Fowler PsycCRITIQUESTable of ContentsAcknowledgmentsPrologue: Setting the Stage for Life after StrokeIntroduction: When Stroke Moves In: How Stroke Affects You and Your Marriage1. The Secret Ingredient: Stroke and Social Support2. You Are the One: Balancing the Roles of Caregiver and Marriage Partner3. A Fine Romance: Sex and Intimacy after Stroke4. Give Me a Break: Support for the Caregiving Spouse5. In Sickness and in Health: Rebuilding Your Marriage after Stroke6. 'Til Death Do Us Part: Going the Distance with Your Spouse after StrokeEpilogue: From This Day On: The Future of CaregivingNotesResourcesIndex

Read more less

Book SynopsisPrecision medicine is rapidly becoming the standard-of-care for the treatment of cancer patients. Precision Medicine Oncology: A Primer is a concise review of the fundamental principles and applications of precision medicine, and intended for clinicians, particularly those working in the field of oncology.Table of ContentsPreface: Introduction to Precision Medicine Authors: Lorna Rodriguez-Rodriguez, MD, PhD, Kim M. Hirshfield, MD, PhD, Shridar Ganesan, MD, PhD Chapter I: Genomic Technology/Next-Generation Sequencing Authors: Hossein Khiabanian, PhD, Shridar Ganesan, MD, PhD, Kim M. Hirshfield, MD, PhD, Gregory Riedlinger, MD, PhD, Chapter II: The Precision Medicine Oncology Molecular Tumor Board: Interpreting and Applying Precision Medicine to Patient Care Authors: Shridar Ganesan, MD, PhD, Kim M. Hirshfield, MD, PhD, Gregory Riedlinger, MD, PhD, Lorna Rodriguez-Rodriguez, MD, PhD Chapter III: Clinical Research in Precision Medicine Oncology Authors: Kim M. Hirshfield, MD, PhD, Shridar Ganesan, MD, PhD Chapter IV: Infrastructures in Precision Medicine Oncology: Biobanks, Biomedical Informatics, and Big Data Authors: Shridar Ganesan, MD, PhD, Kim M. Hirshfield, MD, PhD Chapter V: Future Directions in Precision Medicine Oncology Authors: Shridar Ganesan, MD, PhD, Kim M. Hirshfield, MD, PhD, Lorna Rodriguez-Rodriguez, MD, PhD

Read more less

Book SynopsisThis book addresses consequences on the cardiovascular system that arise from iatrogenesis— the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one’s expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors.Table of ContentsTABLE OF CONTENTS Part I: MEDICAL HARM 1. The Concept and Spectrum of "Iatrogenicity" I. Gussak and J. Kostis 2. Iatrogenicity: Definition, History and Modern Context M. Gussak, I. Gussak, and J. Kostis 3. Epidemiology and Public Health Aspects and Implications: Regulatory, Legal and Ethical Dimensions of Iatrogenicity S. Jones and M. Gonzalez 4. Risk Management: The Medical Center Administration Perspective S. Jones and M. Gonzalez 5. Iatrogenicity from the Patient's Perspective J. Dobrzynski, S. Jones, and M. Gonzalez 6. A Naturopathic Perspective on Iatrogenesis C. Fleetwood Part II: IATROGENICITY OF CARDIOVASCULAR DURGS AND CARDIOVASCULAR TOXICITY OF NON-CARDIAC DRUGS 7. Clinical Manifestations of Acute and Chronic Drug-Induced Iatrogenic Cardiovascular Diseases and Syndromes I. Gussak, G. Yan, A. Jahangir, and J. Kostis 8. Drug-Induced Cardiac Arrhythmias and Sudden Cardiac Death A. Narichania, Y. Yokoyama, and W.K. Shen 9. Chemotherapy-Induced Cardiomyopathies E. Birati and B. Jessup 10. Iatrogenicity of Blood Pressure Mesaurement in the Diagnosis of Hypertension T. Giles, G. Sander, I. Gussak, and J. Kostis 11. Antihypertensive Drug-Induced Iatrogenic Cardiovascular Syndromes R. Kalaitzidis and G. Bakris 12. Iatrogenicity of Cardiovascular Drugs Associated with Cardiac and Non-Cardiac Toxicities: Antihypertensive Agents and Biologics E. Hermes-Desantis and J. Barone 13. Iatrogenic Aspects of Hypertension in Pregnancy: Focus on Preeclampsia C. Thomopoulos and T. Makris 14. Women and Iatrogenic Cardiovascular Disease: Menopausal Estrogen as the Prime Suspect G. Bachmann, M. Rees, and N. Phillips 15. Iatrogenic Aspects of Lipid-Lowering Agents, Thrombolytic, Antiplatelet, and Antithrombotic Agents C. Tsioufis, D. Konstantinidis, N. Vogiatzakis, and K. Dimitriadis 16. Iatrogenic Effects of ‘Urologic' Drugs on the Cardiovascular System K. Stavropoulos, C. Boutari, K. Imprialos, and M. Doumas 17. Iatrogencity and Antianginal Drugs A. Moreyra and W.J. Kostis 18. Anti-Diabetic Drugs and Cardiovascular Risk: Where Do We Stand? R. Kumar 19. Cardiovascular Iatrogenicity in Older Adults A. Khan, #. Ali, #. Iyengar, #. Hagiwara, #. Periyakoil, #. Patel, #. Malone Part III: IATROGENCITY OF DIAGNOSTIC AND THERAPEUTIC, INVASIVE AND NON-INVASIVE CARDIOVASCULAR INTERVENTION, DEVICES, AND SURGERIES 20. Iatrogenic Aspects of Non-Invasive and Invasive Diagnostic Methods in Interventional Cardiology C. Dösch, D. Loßnitzer, T. Papavassiliu 21. Iatrogenicity Associated with Interventional Treatment Modalities N.V. Pothineni, A. Garg, H. Paydak, and J.L. Mehta 22. Iatrogenicity of Diagnostic and Therapeutic, Invasive and Non-Invasive Cardiovascular Interventions, Devices and Surgeries M. Behnes, T. Becher, S. Baumann, and I. Akin 23. Iatrogenic Aspects in Cardiac Electrophysiology B. Rudic, E. Tülümen, and V. Liebe 24. Iatrogenic Aspects in Cardiac Device Therapy S. Röger and J. Kuschyk 25. Cardiovascular Iatrogencity of Respiratory Therapeutic Modalities M.S. Nolledo, P. Lerma and T.V. Santiago Part IV: IATROGENIC ASPECTS OF SPORT CARDIOLOGY AND LIFE-STYLE MODIFICATIONS 26. Professional Athletes G. Mancia 27. Sports Cardiology G. Campanile 28. Dangers of Lifestyle Modification Advice G. Campanile Part V: IATROGENICITY OF DIETARY SUPPLEMENTS, HERBAL PRODUCTS, AND OTHER NON-TRADITIONAL THERAPIES IN CARDIOVASCULAR MEDICINE 29. Safety of Over-the-Counter ‘Natural Substances’ and Vitamins: Side-effects and Contraindications S. Sultan, A. Jahangir, C. Ding, H. Cao, J.B. Kostis, I.B. Gussak, and A. Jahangir 30. Interactions Between Supplements and Prescription Medications S. Sultan, A. Jahangir, C. Ding, H. Cao, J.B. Kostis, I.B. Gussak, and A. Jahangir Acknowledgments Index

Read more less

Book SynopsisThis book addresses consequences on the cardiovascular system that arise from iatrogenesis— the occurrence of untoward effects resulting from actions of health care providers, including medical errors, medical malpractice, practicing beyond one’s expertise, adverse effects of medication, unnecessary treatment, inappropriate screenings, and surgical errors.Table of ContentsTABLE OF CONTENTS Part I: MEDICAL HARM 1. The Concept and Spectrum of "Iatrogenicity" I. Gussak and J. Kostis 2. Iatrogenicity: Definition, History and Modern Context M. Gussak, I. Gussak, and J. Kostis 3. Epidemiology and Public Health Aspects and Implications: Regulatory, Legal and Ethical Dimensions of Iatrogenicity S. Jones and M. Gonzalez 4. Risk Management: The Medical Center Administration Perspective S. Jones and M. Gonzalez 5. Iatrogenicity from the Patient's Perspective J. Dobrzynski, S. Jones, and M. Gonzalez 6. A Naturopathic Perspective on Iatrogenesis C. Fleetwood Part II: IATROGENICITY OF CARDIOVASCULAR DURGS AND CARDIOVASCULAR TOXICITY OF NON-CARDIAC DRUGS 7. Clinical Manifestations of Acute and Chronic Drug-Induced Iatrogenic Cardiovascular Diseases and Syndromes I. Gussak, G. Yan, A. Jahangir, and J. Kostis 8. Drug-Induced Cardiac Arrhythmias and Sudden Cardiac Death A. Narichania, Y. Yokoyama, and W.K. Shen 9. Chemotherapy-Induced Cardiomyopathies E. Birati and B. Jessup 10. Iatrogenicity of Blood Pressure Mesaurement in the Diagnosis of Hypertension T. Giles, G. Sander, I. Gussak, and J. Kostis 11. Antihypertensive Drug-Induced Iatrogenic Cardiovascular Syndromes R. Kalaitzidis and G. Bakris 12. Iatrogenicity of Cardiovascular Drugs Associated with Cardiac and Non-Cardiac Toxicities: Antihypertensive Agents and Biologics E. Hermes-Desantis and J. Barone 13. Iatrogenic Aspects of Hypertension in Pregnancy: Focus on Preeclampsia C. Thomopoulos and T. Makris 14. Women and Iatrogenic Cardiovascular Disease: Menopausal Estrogen as the Prime Suspect G. Bachmann, M. Rees, and N. Phillips 15. Iatrogenic Aspects of Lipid-Lowering Agents, Thrombolytic, Antiplatelet, and Antithrombotic Agents C. Tsioufis, D. Konstantinidis, N. Vogiatzakis, and K. Dimitriadis 16. Iatrogenic Effects of ‘Urologic' Drugs on the Cardiovascular System K. Stavropoulos, C. Boutari, K. Imprialos, and M. Doumas 17. Iatrogencity and Antianginal Drugs A. Moreyra and W.J. Kostis 18. Anti-Diabetic Drugs and Cardiovascular Risk: Where Do We Stand? R. Kumar 19. Cardiovascular Iatrogenicity in Older Adults A. Khan, #. Ali, #. Iyengar, #. Hagiwara, #. Periyakoil, #. Patel, #. Malone Part III: IATROGENCITY OF DIAGNOSTIC AND THERAPEUTIC, INVASIVE AND NON-INVASIVE CARDIOVASCULAR INTERVENTION, DEVICES, AND SURGERIES 20. Iatrogenic Aspects of Non-Invasive and Invasive Diagnostic Methods in Interventional Cardiology C. Dösch, D. Loßnitzer, T. Papavassiliu 21. Iatrogenicity Associated with Interventional Treatment Modalities N.V. Pothineni, A. Garg, H. Paydak, and J.L. Mehta 22. Iatrogenicity of Diagnostic and Therapeutic, Invasive and Non-Invasive Cardiovascular Interventions, Devices and Surgeries M. Behnes, T. Becher, S. Baumann, and I. Akin 23. Iatrogenic Aspects in Cardiac Electrophysiology B. Rudic, E. Tülümen, and V. Liebe 24. Iatrogenic Aspects in Cardiac Device Therapy S. Röger and J. Kuschyk 25. Cardiovascular Iatrogencity of Respiratory Therapeutic Modalities M.S. Nolledo, P. Lerma and T.V. Santiago Part IV: IATROGENIC ASPECTS OF SPORT CARDIOLOGY AND LIFE-STYLE MODIFICATIONS 26. Professional Athletes G. Mancia 27. Sports Cardiology G. Campanile 28. Dangers of Lifestyle Modification Advice G. Campanile Part V: IATROGENICITY OF DIETARY SUPPLEMENTS, HERBAL PRODUCTS, AND OTHER NON-TRADITIONAL THERAPIES IN CARDIOVASCULAR MEDICINE 29. Safety of Over-the-Counter ‘Natural Substances’ and Vitamins: Side-effects and Contraindications S. Sultan, A. Jahangir, C. Ding, H. Cao, J.B. Kostis, I.B. Gussak, and A. Jahangir 30. Interactions Between Supplements and Prescription Medications S. Sultan, A. Jahangir, C. Ding, H. Cao, J.B. Kostis, I.B. Gussak, and A. Jahangir Acknowledgments Index

Read more less

Book SynopsisHaving had the privilege of working throughout Africa, Asia, and Latin America, as well as in the great medical centers of Europe and the United States, the author presents the essential details for understanding pathogenesis, clinical manifestations, therapy, and prevention of the major tropical diseases.Trade Review"Diplomats who must deal with the after-effects of man-made and natural disasters are well aware that epidemic diseases flourish as societies collapse, and that more people usually die in such circumstances from preventable illnesses than from armed conflicts. This is an essential book for those who seek to restore peace and stability in war-torn and disaster areas. It considers the critical interrelationships of medicine and statesmanship, and it is one of the reasons why I have asked the author to serve as my Chief Adviser on Humanitarian and Public Health issues." -- -H.E. Nassir Al Nasser President, United Nations General Assembly, Sixty-sixth Session "This revised and expanded edition of Tropical Medicine: A Clinical Text reflects the personal experience of the author over many years of direct and intimate contact with countries in the Third World, ranging from those in Africa to those in South America. It has been the standard textbook used by many generations of both medical students and postgraduate physicians studying tropical medicine at the Royal College of Surgeons in Ireland and in other academic centers around the world. It is a practical and very readable textbook." -- -Herbert Gilles, M.D., C.M.G. Professor Emeritus, The Liverpool School of Tropical Medicine; Past President, The Royal Society of Tropical Medicine and Hygiene "... A 'must' for any medical collection. It provides a world history of tropical medicine approaches and comes from a doctor who himself has worked throughout the world in both Third World and developed countries." -California Bookwatch

Read more less

Book SynopsisFrom its initial clinical use, over 28 years ago, to its current extensive use (over 100,000 times annually in the US alone), balloon pump equipment has developed into sophisticated, computer--assisted technology for mechanically aiding circulation.Trade Review"...well written and well organized. It should be welcome as a reference text to the libraries of multidisciplinary teams caring for cardiac patients." --Canadian Journal of Surgery "This book presents a comprehensive and up to date review of the use of the intra-aortic balloon pump (IABP) ...The sections on balloon pump equipment, consoles and catheters, and the physiology of balloon pumping are all particularly good, and perhaps should be mandatory reading for all trainees in cardiac surgery, cardiac anesthesia, invasive cardiology and clinical perfusion. "It is a worthwhile addition to the library of a busy cardiovascular critical care unit in which IABPs are used frequently, and is a good reference text for anyone who is considering research involving the IABP." --Canadian Journal of AnesthesiaTable of ContentsSection I: Assisted Circulation. 1. The Principle of Circulatory Assist. 2. Pulsatile Assist Devices and Counterpulsation. Section II: Cardiac Function and Pathophysiology of Cardiac Failure. 3. Cardiac Function and Classification Of Cardiac Failure. 4. Cardiogenic Shock. Section III: The Intra-Aortic Balloon Pump. 5. Historical Background. 6. Balloon Pump Equipment. 7. Balloon Pump Consoles and Catheters. 8. Physiology of Balloon Pumping. 9. General Criteria, Contraindications and Guidelines for Balloon Pumping. 10. Methods of Insertion and Removal of Intra-Aortic Balloon Catheter. 11. Complications of Balloon Pumping. Section IV: Management of Patients on Intra-Aortic Balloon Pump. 12. Nursing Care Of Patients on Intra-Aortic Balloon Pump. 13. Hemodynamic Monitoring, Data Acquisition and Assessment of Efficacy of Diastolic Augmentation. 14. Pharmacologic Treatment. 15. Management of Patients on Intra-Aortic Balloon Pump in Special Situations. 16. Problems With Use of Balloon Pumping. 17. Weaning from Intra-Aortic Balloon Pump Assist. 18. System Management in Patients on Intra-Aortic Balloon Pump. 19. Ancillary Measures in Care of Patients on Intra-Aortic Balloon Pump. Section V: Indications for Use of Intra-Aortic Balloon Pump. 20. An Overview. 21. Intra-Aortic Balloon Pump for Coronary Artery Disease. 22. Balloon Pumping in Cardiogenic Shock. 22. Balloon Pumping in Cardiac Surgery. 23. Miscellaneous Indications for Balloon Pumping

Read more less

Book SynopsisIn the last two decades, tremendous strides in the field of mechanical support have extended the lives of countless sufferers of congestive heart failure, who total close to 1% of the US population.Trade Review"Five Stars.... a very thorough and concise review of all cardiac assist devices. The content is exceptional in completeness.... The quality of this book is excellent. It is a complete reference on this interesting and constantly changing topic. The book is highly educational and an outstanding contribution to the field." (Doody's Review Service) "Cardiac Assist Devices fills an important need by covering a fast-growing field in cardiac medicine and surgery." (Texas Heart Institute Journal) "Drs. Goldstein and Oz have put their names to a landmark book in the field of mechanical cardiac support. They have drawn 70 authors together, each well known in this field and each recognized for their contribution to this rapidly developing service. These authors represent the historical breadth and world's experience of this fascinating subject.... All those in the field will want access to it and because of its quality will want to own it. All those who wish to comment on this subject will be better informed by reading it. And those who just wish to be aware of what is going on in the arena of mechanical assistance of the failing heart will thoroughly enjoy the authoritative read." (Perfusion) "This book is invaluable to the practicing cardiac surgeon and cardiologists who deal with patients who may require cardiac support devices." (Current Surgery) "This book is an excellent reference for this highly specialized field of cardiology." (Pediatric Cardiology)Table of ContentsForeword. Bill Frist, MD. Part I: General Aspects of Mechanical Support. 1. Clinical Left Heart Assist Devices: A Historical Perspective. O.H. Frazier, MD, John M. Fuqua, Jr., and David N. Helman, MD. 2. Physiology of Ventricular Interactions During Ventricular Assistance. David J. Farrar, PhD. 3. Device Selection. Benjamin C. Sun, MD. 4. Options for Mechanical Support in Pediatric Patients. Tom R. Karl, MD and Stephen B. Horton, MD. 5. Anesthetic Considerations During Left Ventricular Assist Device Implantation. Marc L. Dickstein, MD, Berend Mets, MB, ChB, FRCA, PhD, and Mark J.S. Heath, MD. 6. Perioperative Management of Bleeding. Clifford H. Van Meter, Jr., MD. 7. Management of Perioperative Right-Sided Circulatory Failure. Jonathan M. Chen, MD and Eric A. Rose, MD. 8. Perioperative Management of Arrhythmias in Recipients of Left Ventricular Assist Devices. Matthew Williams, MD and James Coromilas, MD. 9. Management of Vasodilatory Hypotension after Left Ventricular Assist Device Placement. Michael Argenziano, MD and Donald W. Landry, MD, PhD. 10. Left Ventricular Recovery During Left Ventricular Assist Device Support. Johannes Mueller, MD and Roland Hetzer, MD. 11. Exercise Performance in Patients with Left Ventricular Assist Devices. Donna Mancini, MD and Ainat Beniaminovitz, MD. 12. Outpatient Support. Katherine A. Catanese, MSN and David L.S. Morales, MD. 13. Rehabilitation of the Ventricular Assist Device Recipient. Theresa M. Morrone, MS, PT, C.C.S. and Lori A. Buck, MS, PT, C.C.S. 14. Quality of Life Issues Associated with the Use of Left Ventricular Assist Devices. Peter A. Shapiro, MD. 15. Economic Considerations of LVAD Implantation. Alan J. Moskowitz, MD, Deborah L. Williams, MPH, Anita Tierney, MPH, Ronald G. Levitan, BS, Joshua Zivin, PhD, and Annetine C. Gelijns, PhD. 16. Immunobiology of Left Ventricular Assist Devices. Jan-Hendrik Ankersmit, MD and Silviu Itescu, MD. . Part II: Available Devices:. A. Extracorporeal Devices. 17. Extracorporeal Support: Centrifugal Pumps. Jack J. Curtis, MD and Colette Wagner-Mann, DVM, PhD. 18. Extracorporeal Support: The ABIOMED BVS 5000. G. Kimble Jett, MD and Robert R. Lazzara, MD. 19. Extracorporeal Support: The Thoratec Device. D. Glenn Pennington, MD, Timothy E. Oaks, MD, and Douglas P. Lohmann, M.Eng.. 20. Extracorporeal Membrane Oxygenation in Adults. Richard J. Kaplon, MD and Nicholas G. Smedira, MD. 21. Extracorporeal Support: The Berlin Heart. Matthias Loebe, MD, PhD, Friedrich Kaufmann, and Roland Hetzer, MD, PhD. . Part II: Available Devices:. B. Intracorporeal Devices. 22. Intracorporeal Support: The Intra-aortic Balloon Pump. David N. Helman, MD and Gus J. Vlahakes, MD. 23. Intracorporeal Support: Thermo Cardiosystems Ventricular Assist. Daniel J. Goldstein, MD. 24. Intracorporeal Support: Novacor Left Ventricular Assist System. Naraynan Ramasamy, PhD, Rita L. Vargo, MSN, RN, Robert L. Kormos, MD, and Peer M. Portner, Phd. 25. Intracorporeal Support: Cardiowest Total Artificial Heart. Jack Copeland, MD, Francisco Arabia, MD, Richard Smith, MSEE, and Paul Nolan, PhDPart III: Future Devices. 26. Axial Flow Pumps. Joseph J. DeRose, Jr., MD and Robert K. Jarvik, MD. 27. The DeBakey Ventricular Assist Device. George P. Noon, MD, Deborah Morley, PhD, Suellen Irwin, RN, and Michael E. DeBakey, MD. 28. Epicardial Compression Mechanical Devices. John H. Artrip, MD and Daniel Burkhoff, MD, PhD. 29. The Pennsylvania State University Totally Implantable LVAD and Total Artificial Heart. Sanjay M. Mehta, MD and Walter E. Pae, Jr., MD. 30. The HeartSaver VAD: A Fully Implantable VAD for Long-Term Support. Tofy Mussivand, Paul J. Hendry, Roy G. Masters, and Wilbert J. Keon

Read more less

Book SynopsisOffering a holistic view of the development of drug delivery systems, Advanced Drug Delivery presents the essential aspects necessary to understand and apply for effective drug delivery fundamentals, including practical issues, integration of pharmaceutics, and molecular biology.Trade Review“This book is a welcome addition to the range of study materials available at this level and can be unreservedly recommended to both aspiring and existing pharmaceutical professionals.” (ChemMedChem, 1 January 2015) “A suitable text for graduate and advanced undergraduate students, the book is logically divided into four sections: fundamentals, delivery approaches, disease applications, and future directions. Discussing design, in vitro studies, clinical evaluation, and regulatory approval, each chapter includes objectives and assessment questions.” (Newbooks.lib, 11 September 2014Table of ContentsPREFACE xi ABOUT THE AUTHORS xiii CONTRIBUTORS xv PART I INTRODUCTION AND BASICS OF ADVANCED DRUG DELIVERY 1 1 Physiological Barriers in Advanced Drug Delivery: Gastrointestinal Barrier 3 D. Alexander Oh and Chi H. Lee 2 Solubility and Stability Aspects in Advanced Drug Delivery 21 Hoo-Kyun Choi, Robhash K. Subedi, and Chi H. Lee 3 The Role of Transporters and the Efflux System in Drug Delivery 47 Varun Khurana, Dhananjay Pal, Mukul Minocha, and Ashim K. Mitra 4 Biomaterial in Advanced Drug Delivery 75 Megha Barot, Mitesh Patel, Xiaoyan Yang, Wuchen Wang, and Chi H. Lee PART II STRATEGIES FOR ADVANCED DRUG DELIVERY 103 5 Strategies of Drug Targeting 105 Ravi S. Shukla, Zhijin Chen, and Kun Cheng 6 Prodrug and Bioconjugation 123 Ramya Krishna Vadlapatla, Sujay Shah, Aswani Dutt Vadlapudi, and Ashim K. Mitra 7 Nanoscale Drug Delivery Systems 141 Mitan R. Gokulgandhi, Ashaben Patel, Kishore Cholkar, Megha Barot, and Ashim K. Mitra 8 Stimuli-Responsive Target Strategies 157 Chi H. Lee 9 Implants 183 Aswani Dutt Vadlapudi, Ashaben Patel, Ramya Krishna Vadlapatla, Durga Paturi, and Ashim K. Mitra 10 Aptamers in Advanced Drug Delivery 201 Weiwei Gao, Omid C. Farokhzad, and Nazila Kamaly 11 Nanofiber 219 Megha Barot, Mitan R. Gokulgandhi, Animikh Ray, and Ashim K. Mitra 12 Biomimetic Self-Assembling Nanoparticles 231 Maxim G. Ryadnov 13 Protein and Peptide Drug Delivery 241 Mitesh Patel, Megha Barot, Jwala Renukuntla, and Ashim K. Mitra 14 Delivery of Nucleic Acids 257 Shaoying Wang, Bin Qin, and Kun Cheng 15 Delivery of Vaccines 275 Hari R. Desu, Rubi Mahato, and Laura A. Thoma PART III TRANSLATIONAL RESEARCH OF ADVANCED DRUG DELIVERY 297 16 Regulatory Considerations and Clinical Issues in Advanced Drug Delivery 299 Mei-Ling Chen 17 Advanced Drug Delivery in Cancer Therapy 323 Wanyi Tai and Kun Cheng 18 Advanced Delivery in Cardiovascular Diseases 341 Gayathri Acharya, Wuchen Wang, Divya Teja Vavilala, Mridul Mukherji, and Chi H. Lee 19 Recent Advances in Ocular Drug Delivery 365 Varun Khurana, Deep Kwatra, Vibhuti Agrahari, and Ashim K. Mitra 20 Advanced Drug Delivery Against STD 381 Chi H. Lee 21 Advanced Drug Delivery to the Brain 405 Nanda K. Mandava, Mitesh Patel, and Ashim K. Mitra PART IV FUTURE APPLICATIONS OF ADVANCED DRUG DELIVERY IN EMERGING RESEARCH AREAS 423 22 Cell-Based Therapeutics 425 Zhaoyang Ye, Yan Zhou, Haibo Cai, and Wen-Song Tan 23 Biomedical Applications and Tissue Engineering of Collagen 445 Chi H. Lee and Yugyung Lee 24 Molecular Imaging of Drug Delivery 469 Zheng-Rong Lu ANSWERS 489 INDEX 511

Read more less

Book SynopsisThis book is an introduction to the emerging field of nanomedicine and its applications to health care. It describes the many multidisciplinary challenges facing nanomedicine and discusses the required collaboration between chemists, physicists, engineers and clinicians.Trade Review“This volume is most handy for those in the physics, chemistry, or materials science fields who are interested in biomedical applications of nanotechnology; it would also be useful for those in the biological or medical fields who are interested in learning how nanotechnology would be beneficial to their research. Summing Up: Recommended. Upper-division undergraduates and above.” (Choice, 1 January 2013)Table of ContentsPreface xiii Acknowledgments xv 1 Introduction 1 1.1. Nanomedicine: A Global Vision 1 1.2. The Nanotechnology Revolution: Realization of Asimov’s Fiction 3 1.3. Nanomedicine: A New Era in Personalized Medicine 7 1.4. Nanomedicine: A Promise or Reality? 9 1.5. A New Frontier: Multidisciplinary Challenges and Opportunities 10 1.6. Scope of the Book: Multidisciplinary Education, Training, and Research 12 References 13 2 The Human Body 15 2.1. Introductory Concepts 16 2.2. Cellular Structure 18 2.3. Various Types of Cells 23 2.4. Biochemical Makeup of Cells 25 2.5. Other Important Cellular Components 29 2.6. Cellular Processes 30 2.7. Organization of Cells into Tissues 37 2.8. Types of Tissues and Their Functions 39 2.9. Various Organs and Organ Systems in the Body 40 2.10. Tumors and Cancers 45 Highlights of the Chapter 46 Exercises 48 References 49 3 Nanocarriers 51 3.1. Nanocarriers: Delivering Payloads to Needed Sites 52 3.2. The Various Nanoformulations for Nanomedicine 53 3.3. Viruses as Nanocarriers 55 3.4. Polymeric Nanocarriers 56 3.5. Lipid-Based Nanocarriers 58 3.6. Dendrimers 59 3.7. Carbon Nanostructures 61 3.8. Inorganic Nanoparticles 63 3.9. PEBBLE 65 3.10. Nanoclinics 66 3.11. Nanoplexes 68 3.12. New-Generation Nanocarriers 69 Highlights of the Chapter 70 Exercises 72 References 73 4 Nanochemistry of Nanocarriers 77 4.1. Nanochemistry and Nanomedicine 78 4.2. Top-Down Approaches 78 4.2.1. Mechanical Milling 79 4.2.2. Dip-Pen Nanolithography 79 4.2.3. PRINT Process 81 4.2.4. Laser Ablation 81 4.3. Bottom-Up Approaches 83 4.3.1. Dendrimers 83 4.3.2. Microemulsion Chemistry 86 4.3.3. Hot-Colloidal Synthesis 87 4.3.4. Seed-Mediated Synthesis of Anisotropic Metallic Nanostructures 90 4.3.5. Reprecipitation Method 90 4.4. Combination of Bottom-Up and Top-Down Approaches 92 4.5. Nanoparticle Surface Modifi cation 93 4.6. Functionalization and Bioconjugation 95 Highlights of the Chapter 97 Exercises 99 References 100 5 Multifunctionalities for Diagnostics and Therapy 103 5.1. The Various Functionalities 104 5.2. Optical Functionalities 105 5.3. Optical Nanoprobes 110 5.4. Magnetic Functionality 116 5.5. Thermal Functionality 120 5.6. Radioactive Functionality 121 5.7. Biological Functionality 124 5.8. Multifunctionality 125 Highlights of the Chapter 128 Exercises 130 References 131 6 Crossing the Biological Barriers 135 6.1. Various Delivery Pathways 135 6.2. Various Biological Barriers 137 6.3. Stealth Nanoparticles 140 6.4. The Various In Vitro Barrier Models 141 Highlights of the Chapter 144 Exercises 145 References 146 7 Biotargeting 149 7.1. Biotargeting: Why We Need It 149 7.2. Targeted Biological Sites 150 7.3. Intracellular Uptake 151 7.4. Targeting Strategies 153 7.5. Targeting Groups 155 Highlights of the Chapter 159 Exercises 160 References 161 8 Multimodal Biomedical Imaging 163 8.1. Biomedical Imaging Techniques 164 8.2. Optical Bioimaging 170 8.2.1. Fluorescence Microscopy 170 8.2.2. Quantitative FRET Microscopy 172 8.2.3. Technical Challenges for In Vitro Imaging 175 8.2.4. In Vivo Optical Imaging 177 8.2.5. Optical Coherence Tomography 177 8.2.6. Super-Resolution Fluorescence Microscopy 181 8.3. Magnetic Resonance Imaging 185 8.4. X-Ray CT Imaging 188 8.5. Radio Imaging 190 8.6. Ultrasound Imaging 190 8.7. Photoacoustic Imaging 191 8.8. Multimodal Imaging 192 Highlights of the Chapter 193 Exercises 200 References 201 9 Biosensing 207 9.1. Principles of Biosensing 208 9.2. Optical Biosensors 211 9.2.1. Fluorescencs Sensors 211 9.2.2. Plasmonic Sensors 218 9.2.3. Photonic Crystal Sensors 227 9.3. Magnetic Biosensors 228 9.4. Electrical Biosensing 234 9.5. Electrochemical Biosensing 236 9.6. Electrochemiluminescence Biosensing 238 9.7. In Vivo Bioelectronic Sensors 239 Highlights of the Chapter 241 Exercises 245 References 247 10 High-Throughput Multiplexed Diagnostics 253 10.1. Comprehensive Diagnostic Strategy 254 10.2. Flow Cytometry 255 10.3. Enzyme-Linked Immunosorbent Assay (ELISA) 264 10.4. Microarrays Technology 269 10.5. Suspension Bead Assay 277 Highlights of the Chapter 281 Exercises 285 References 286 11 Nanopharmacotherapy 291 11.1. Nanopharmacotherapy: An Overview 292 11.2. Modes of Nanoformulation for Nanopharmacotherapy 294 11.3. Pharmacokinetics 296 11.4. Biodistribution 297 11.5. Pharmacodynamics 298 11.6. Controlled Release by External Activation 299 Highlights of the Chapter 300 Exercises 302 References 303 12 The Human Circulatory System and Theranostics 305 12.1. Blood Fluidics and Cardiovascular System 306 12.2. Circulatory-System-Based Disease Profi ling 309 12.3. Methods to Monitor Blood Flow 312 12.4. Therapeutic Approaches Utilizing Manipulation of Blood Flow 318 12.5. Lymph Node Mapping 320 12.6. Lymphatic Drug Delivery 322 Highlights of the Chapter 322 Exercises 326 References 327 13 Nanotechnology for Cancer 331 13.1. Benefits of Cancer Nanotechnology 332 13.2. Chemotherapy 335 13.3. Cancer Gene Therapy 339 13.4. Photodynamic Therapy 340 13.5. Magnetic Therapy 349 13.6. Photothermal Therapy 353 13.7. Neutron Capture Therapy 357 13.8. Circulating Tumor Cells 359 13.9. NCI Alliance for Cancer Nanotechnology 360 Highlights of the Chapter 360 Exercises 362 References 364 14 Gene Therapy 371 14.1. The Principles, Steps, and Impact of Gene Therapy 372 14.2. Methods of Gene Delivery 374 14.3. Gene Augmentation Therapy 381 14.4. Gene Silencing Therapy 381 14.5. Indirect Gene Therapy Modulating Innate Immune Response 384 14.6. Transmucosal Gene Delivery 385 Highlights of the Chapter 386 Exercises 388 References 390 15 Nanotechnology for Infectious Diseases 393 15.1. Pathogen Infections and Nanoparticle-Based Approaches 394 15.2. HIV 401 15.2.1. Diagnosis 402 15.2.2. Vaccines and Antimicrobial Drugs 404 15.2.3. Therapy 405 15.3. Influenza 408 15.3.1. Diagnosis 408 15.3.2. Vaccines 409 15.3.3. Therapy 409 15.4. Tuberculosis 410 15.4.1. Diagnosis 410 15.4.2. TB Vaccine 412 15.4.3. Therapy 412 15.5. Malaria 416 15.5.1. Vaccines 418 15.5.2. Therapy 420 Highlights of the Chapter 422 Exercises 424 References 426 16 Rejuvenation Therapy 433 16.1. Rejuvenation Therapy: Fantasy or Reality? 433 16.2. Free Radical Scavenging 436 16.3. Chelation Therapy 439 16.4. Hormone Therapy 441 Highlights of the Chapter 442 Exercises 443 References 444 17 Stem Cell Biotechnology 447 17.1. Stem Cell Biotechnology: Overview 448 17.2. Cell Reprogramming 449 17.3. Gene Transfection 452 17.4. Somatic Cell Transdifferentiation 453 17.5. Stem Cell Sorting 454 17.6. Stem Cell Tracking 454 Highlights of the Chapter 456 Exercises 456 References 457 18 Tissue Engineering 461 18.1. Tissue Engineering: Overview 462 18.2. Tissue Regeneration 464 18.3. Nanotechnology in Tissue Engineering 467 18.4. Nanofi bers for Tissue Engineering 472 18.5. Nanoparticle Delivery of Biomolecules 473 18.6. Magnetically Assisted Tissue Engineering 474 18.7. Tissue/Organ Printing 475 18.8. Tissue Bonding 477 Highlights of the Chapter 479 Exercises 482 References 484 19 Nanodermatology and Nanocosmetics 487 19.1. Delivery Through Skin 487 19.2. Skin Care and Nanotechnology 488 19.3. Various Nanoparticles for Dermatology and Cosmetics 491 19.4. Nanodermatology 492 19.5. Nanocosmetics 494 19.6. Nanotoxicology of the Skin 497 Highlights of the Chapter 497 Exercises 498 References 499 20 Nanodentistry 503 20.1. Nanotechnology for Dental Care 504 20.2. Nanoparticles for Preventive Dentistry 507 20.3. Nanomaterials for Restorative Dentistry 509 20.4. Regenerative Dentistry 516 20.5. Nanoparticle-Enhanced Dental Imaging and Oral Diagnostics 519 20.6. Nanorobotics for Dentistry 522 Highlights of the Chapter 522 Exercises 524 References 525 21 Nanotoxicity 529 21.1. Toxicity of Nanoparticles 529 21.2. Cytotoxicity 533 21.3. In Vitro Cytotoxicity Assays 535 21.4. In Vivo Toxicity 539 21.5. In Vivo Toxicity Evaluation 542 21.6. Nanotoxicity Studies on Selected Nanoparticles 542 Highlights of the Chapter 547 Exercises 550 References 551 Index 555

Read more less

Book SynopsisA comprehensive review of all types of medical therapeutic delivery solutions from traditional pharmaceutical therapy development to innovative medical device therapy treatment to the recent advances in cellular and stem cell therapy development. It also includes associated regulatory requirements for the development of these therapies.Table of ContentsPreface vii Contributors ix ACKNOWLEDGMENT xi Section 1 Requirements and Issues encountered in Regulatory Submissions in the Pharmaceutical, Cell Therapy and Medical Device Industries 1 1 Challenges to Quality and Regulatory Requirement in the United States—Drugs, Medical Device, and Cell Therapy 3 Section 2 Traditional Pharmaceutical Drug Therapy Development 35 2 Development of Tablets 37 3 Formulation of Poorly Soluble Drugs for Oral Administration 67 Section 3 Overview, Current Trends and Strategies of Special Medical Device Development 105 4 Overview of Drug Delivery Devices 107 5 Local Delivery of Bone Growth Factors 135 6 Delivery of Insulin: From Glass Syringes to Feedback-Controlled Patch Pumps 163 Section 4 Advances and Innovations in Cellular and Stem Cell Therapeutic Delivery 179 7 Endocrine Therapeutic Delivery: Pancreatic Cell Transplant and Growth 181 8 Cell-Based Biologic Therapy for the Treatment of Medical Diseases 207 9 Development of Stem Cell Therapy for Medical Uses 239 Section 5 Analytical Support Needed For the Research and Development 269 10 Specification Setting and Stability Studies in the Development of Therapeutic Delivery Solution 271 11 LC-MS for Pharmaceutical Analysis 315 12 Biorelevant Dissolution Testing 335 13 I CH Quality Guidelines: Their Global Impact 367 14 Out of Specification/Atypical Result Investigation 381 Index 405

Read more less

Book SynopsisYour ticket to acing Clinical Anatomy Clinical anatomy is the study of human anatomy as it relates to clinical practice. Unlike a basic anatomy and physiology course designed to teach general anatomical knowledge, clinical anatomy focuses on specific structures and issues that people may encounter in a clinical setting.Table of ContentsIntroduction 1 About This Book 1 Conventions Used in This Book 1 What You’re Not to Read 2 Foolish Assumptions 2 How This Book is Organized 2 Part I: Beginning with Clinical Anatomy Basics 3 Part II: Understanding the Thorax, Abdomen, and Pelvis 3 Part III: Looking at the Head, Neck, and Back 3 Part IV: Moving to the Upper and Lower Extremities 3 Part V: The Part of Tens 3 Icons Used in This Book 4 Where to Go from Here 4 Part I: Beginning with Clinical Anatomy Basics 5 Chapter 1: Entering the World of Clinical Anatomy 7 Studying the Body in Different Ways 7 Looking under the microscope or with your eyes 7 Speaking clinically: Terms used in clinical anatomy 8 Dividing the Body into Systems and Regions 8 Organizing the body by systems 9 Organizing the body by regions 10 Chapter 2: Getting a Grip on Terms Used in Clinical Anatomy 13 Describing Anatomy by Position, Region, and Plane 13 Beginning with the anatomical position 14 Figuring out what goes where in anatomical regions 14 Knowing what’s up, down, back, and front in specific terms 16 Slicing the body into anatomical planes 17 Labeling Anatomical Movement 19 Bending and straightening 19 Going away and getting closer 19 Moving in circles 20 Surveying other ways to move 20 Chapter 3: Examining the Integumentary, Musculoskeletal, and Nervous Systems 23 Showing Interest in Integument 23 Looking at the layers and structures of the skin 24 Going in farther to the fascia 26 Boning Up on the Skeleton 26 Figuring out what makes a bone 26 Surveying the shapes of bones 27 Feeling out bumps, ridges, and indentations 28 Catching Up to Cartilage 29 Joining the Joints 29 Making the Body Move with Muscles 31 Moving the bones with skeletal muscle 31 Keeping the heart ticking with cardiac muscle 33 Having no control over smooth muscle 34 Getting on Your Nerves 34 Determining what’s in (and on) a neuron 35 Coordinating input and signals with the central nervous system 36 Touching and moving with the peripheral nervous system 36 Feeling and reacting with the somatic nervous system 37 Taking control with the autonomic nervous system 37 Chapter 4: Moving Along with the Cardiovascular and Respiratory Systems 39 Tracing Circulatory Pathways in the Cardiovascular System 39 Making the rounds: Systemic circulation 40 Fueling up: Pulmonary circulation 41 Moving Blood Away from the Heart with Arteries 43 Looking inside large elastic arteries 44 Moving to medium muscular arteries 44 Surveying small arteries and arterioles 44 Taking Blood Back to the Heart with Capillaries and Veins 45 Exchanging gases, nutrients, and wastes in capillaries 45 Peeking into veins and venules 46 Breathing In and Out: The Respiratory System 47 Chapter 5: Looking at the Immune and Lymphatic Systems 49 Beginning with Red Bone Marrow and Leukocytes 49 Fighting infection with lymphocytes 50 Binging on bacteria with phagocytes 50 Controlling histamines with basophils 51 Surveying the Lymphatic System 51 Networking with lymphatic capillaries and vessels 51 Filtering lymph through nodes 52 Collecting lymph in ducts 53 Assessing Additional Lymphoid Organs 54 The thymus 54 The spleen 55 The tonsils, the appendix, and the gut 55 Chapter 6: Delving into the Digestive, Urinary, and Endocrine Systems 57 Breaking Down and Absorbing Your Food: The Digestive System 57 Starting in the mouth 58 Continuing through the esophagus and into the stomach 58 Finishing in the small intestine with help from the pancreas, gallbladder, and liver 59 Forming and removing bulk in the large intestine 59 Removing Wastes: The Urinary System 60 Handling Hormones: The Endocrine System 61 The master gland: The pituitary 61 The pituitary’s assistants: The hypothalamus and pineal glands 62 The body’s metabolism booster: The thyroid gland 62 Fighting infection: The thymus 63 Stressing out: The suprarenals 64 Digestive aid: The pancreas 64 Mars and Venus: The testes and the ovaries 65 Part II: Understanding the Thorax, Abdomen, and Pelvis 67 Chapter 7: Checking Out the Thoracic Cage and Coverings 69 Getting Under Your Skin: Thoracic Bones, Joints, Muscles, and More 69 Forming the thoracic cage: The bones 70 Moving just a little: The joints 72 Helping you breathe: The respiratory muscles 73 Running through the thorax: The nerves and blood vessels 76 Covering It All Up: The Surface Anatomy of the Thorax 78 Using imaginary lines in your assessment 78 Looking at the anterior chest wall 79 Examining the posterior chest wall 82 Chapter 8: Assessing the Thoracic Organs 85 Understanding the Mediastinum and Pleural Cavities 85 The mediastinum 85 The pleural cavities 86 Looking at the Lungs 87 Surveying the lungs’ surfaces and borders 88 Getting air in and out with the trachea 88 Branching into the bronchi 88 Checking out the lobes 89 Flowing with nerves, blood vessels, and lymphatics 90 Having a Heart 93 Surrounding the heart with the pericardium 93 Examining the surfaces of the heart 93 Putting together the four chambers 95 Feeding the heart: Arteries and veins 97 Giving the heart its spark 98 Exploring Thoracic Circulation 101 Circulating blood in the major vessels 101 Moving lymph through the lymphatic vessels 102 Discovering What Else is in the Thoracic Cavity 103 Chapter 9: Bellying Up to the Abdominal Wall 105 Drawing Quadrants and Regions on the Abdominal Wall 105 Using two lines: The four quadrants 106 Using four lines: The nine regions 106 Making Up the Abdominal Wall: Muscles and More 107 Absolutely fabulous abdominal muscles 107 Nerves, blood vessels, and lymphatics for maintaining tissues 108 Lining the abdomen: The peritoneum 112 Inspecting the Inguinal Region 112 The inguinal ligament and the iliopubic tract 112 The inguinal canal 113 The spermatic cord 114 The testes 114 The scrotum 115 Seeing the Skin and Surface Anatomy of the Abdominal Wall 116 Chapter 10: Probing the Abdominal Organs 119 Poking Around the Peritoneum 119 The mesentery and the peritoneal folds and ligaments 120 The greater and lesser omentums 120 Digging into the Main Digestive Organs 121 Entering the esophagus 121 Churning in the stomach 122 Winding through the small intestine 124 Moving into the large intestine 126 Observing Organs that Assist with Digestion 128 Locating the liver 128 Glancing at the gallbladder 132 Pinpointing the pancreas 132 Identifying Renal Anatomy 133 Knowing the kidneys 134 Tracing the ureters 135 Spying the suprarenal glands 135 Figuring Out What Else is in the Abdominal Cavity 136 The spleen 136 Nerves 137 Major abdominal blood vessels 139 Lymphatics 142 Chapter 11: Seeing the Pelvis and the Perineum 145 Pinpointing the Pelvic Structures 145 Forming the pelvic girdle: Bones and joints 146 Making note of muscles and fascia 148 Personal space: The peritoneum 149 Feeling out the nerves of the pelvis 150 Viewing blood vessels 152 Looking at lymphatics 154 Comparing Pelvic Organs 155 Locating pelvic organs that everyone has 155 Finding Mars: The male pelvic organs 157 Finding Venus: The female pelvic organs 159 Exit Strategy: The Perineum 162 The male perineum 164 The female perineum 164 Part III: Looking at the Head, Neck, and Back 167 Chapter 12: Head of the Class 169 Sticking to the Skull Bones 169 Cradling the brain in the cranial cavity 170 Facing forward with the facial bones 172 Encasing the Brain: The Meninges 173 The dural infoldings 173 The dural venous sinuses 174 Locating the Areas and Structures of the Brain 175 Thinking about the cerebrum 177 Going inside the diencephalon 177 Balancing the cerebellum 177 Surveying the brainstem 178 Draining the brain with the ventricles 178 Getting the glands 178 Counting the cranial nerves 179 Serving the brain: The blood supply 182 Putting on a Face 183 Expressing yourself with facial muscles 183 Moving with motor nerves 185 Feeling out sensory nerves 185 Viewing blood vessels 187 Getting a handle on lymphatics 190 Enveloping the Head: Facial Surface Anatomy and the Scalp 190 Chapter 13: Seeing, Smelling, Tasting, and Hearing 193 Seeing into the Eyes 193 Taking cover with eyelids 194 Having a ball — an eyeball, that is 195 Rolling your eyes with extraocular muscles 197 Serving the eyes: The nerves 199 Providing blood flow to and from the eyes 200 Knowing the Nose 201 Sniffing out the exterior of the nose 201 Scoping out the nasal cavity 201 Insinuating your way into the paranasal sinuses 203 Sensing the nerves, blood vessels, and lymphatics 204 Investigating the Mouth 204 Open wide: The oral cavity 204 Chew on this: The teeth and gums 205 Picking on the palate 205 Sticking out your tongue 207 Making spit in the salivary glands 209 Tapping into the temporomandibular joint 209 Noting nerves 211 Viewing blood vessels 212 Sorting through lymphatics 212 Entering the Ear 213 Examining the external ear 213 Moving into the middle ear 214 Diving deeper into the inner ear 216 Keeping an ear out for nerves and vessels 217 Chapter 14: It’s Neck and Neck 219 Sizing Up the Superficial Structures: Muscles, Nerves, and Blood Vessels 219 Dividing the triangles: The sternocleidomastoid 220 Going back to the posterior triangle of the neck 221 Understanding the anterior triangle of the neck 223 Neck Deep: Diving into the Deep Structures 226 Flexing the neck: The prevertebral muscles 226 Rooting around the root of the neck 228 Homing In on the Neck Organs 230 Front and center: Thyroid and parathyroid glands 230 Speaking of the pharynx, larynx, and trachea 231 Locating lymphatic vessels and nodes 236 Surrounding the Neck: Skin and Surface Anatomy 237 Chapter 15: Back to Back 239 Stacking Up the Vertebral Column 239 Analyzing a typical vertebra 240 Putting the vertebrae into groups 241 Connecting with the vertebral joints 244 Studying the Spinal Cord and Meninges 246 Spying on the spinal cord and nerves 246 Coverings and cushions: Understanding the meninges and cerebrospinal fluid 247 Flexing Your Back Muscles 249 Shouldering the load: The extrinsic muscles 249 Twisting and turning: The intrinsic muscles 249 Nodding your head: The suboccipital muscles 252 Providing Blood Flow and Lymphatic Drainage in the Back 254 Assessing the Surface Anatomy of the Vertebrae and Back Muscles 254 Looking for curves in the spine 255 Seeing bones on the back’s surface 255 Viewing the back muscles 256 Part IV: Moving to the Upper and Lower Extremities 257 Chapter 16: Shouldering the Load: The Pectoral Girdle and the Arm 259 Boning Up on the Shoulder and the Arm 259 Looking at the bones of the pectoral girdle 260 It’s not funny, but it’s humerus 261 Joining the Parts 262 Collaring the sternoclavicular joint 262 Reviewing the acromioclavicular joint 262 Hanging on to the humerus 263 Sniffing around the Axilla (Armpit) 264 Forming the apex, the base, and the walls 264 Tracking the axillary artery and vein 265 Moving the Shoulder and the Arm 265 Taking a look at the anterior muscles 265 Moving to the posterior muscles 267 Shaping up the shoulder muscles 267 Maintaining the Tissues 269 Acknowledging the nerves and blood supply 269 Remembering the lymphatic vessels 273 Covering Your Shoulders and Arms: The Surface Anatomy 274 Chapter 17: Bending the Elbow and Focusing on the Forearm 277 Forming the Elbow and the Forearm: The Bones 277 Handling the humerus 277 Regarding the radius 278 Understanding the ulna 278 Joining the Elbow and the Forearm 279 Bending the elbow 279 Reviewing the radioulnar joints 279 Making the Elbow and Forearm Move: The Muscles 280 The muscles of the arm 280 The muscles of the forearm 282 Giving a Nod to the Nerves and Blood Supply 282 Nerves 284 Blood supply 284 Looking Only Skin Deep: The Surface Anatomy 285 Chapter 18: Shaking Hands and Grabbing the Wrist 287 Putting Your Hands (and Wrists) Together 287 Starting with the carpal bones 288 Moving to the metacarpal bones 289 Finding the phalanges 290 Waving and Wiggling with the Help of Joints 290 Looking at the wrist joints 290 Handing over the hand joints 291 Pointing to the finger joints 291 Making the Most of Wrist and Hand Muscles 292 Flexing and extending the wrist 292 Sticking out your thumb with the thenar muscles 296 Honing in on the hypothenar muscles 296 Investigating the interosseous muscles and the lumbricals 297 Knowing the Nerves and Blood Supply of the Wrist and Hand 297 Getting a feeling for the nerves 298 Uncovering the arteries and veins 299 Fitting Like a Glove: The Surface Anatomy of the Wrist and Hand 300 Chapter 19: Getting Hip to the Hip and the Thigh 303 Honing In on Hip and Thigh Bones 303 Understanding the Hip and Thigh Joints 306 Seeking the sacroiliac joint 306 Surveying the symphysis pubis 307 Looking at the acetabulofemoral joint 307 Swaying Your Hips and Moving Your Thighs with the Help of Muscles 308 Minding the muscles of the buttocks 308 Turning with the thigh muscles 310 Maintaining the Hip and Thigh Tissues 312 Knowing the nerves 313 Flowing through the arteries and veins 315 Looking at the lymphatics 316 Summing Up the Surface Landmarks 317 Chapter 20: Knowing the Knee and the Leg 319 Logging the Knee and Leg Bones 319 Knocking the Knee Joint 322 Coming up with cartilage and the joint capsule 322 Balancing the menisci 322 Hanging on with the ligaments 324 Bumping up against the bursae 325 Kneeling on the patellofemoral joint 326 Supervising the superior tibiofibular joint 326 Mastering the Muscles that Affect the Knee and Leg 326 Starting with thigh muscles that work with the knee 327 Aiming at the anterior compartment 327 Looking at the lateral compartment 328 Pondering the posterior compartment 328 Noticing the Nerves, Blood Vessels, and Lymphatics of the Knee and Leg 329 Noting the nerves 329 Analyzing the arteries and veins 331 Listing the lymph nodes 332 Summing Up the Surface Landmarks 332 Chapter 21: Finding the Ankle and the Foot 335 Looking at the Framework of the Ankle and Foot 335 Aiming for the ankle bones 336 Assessing the architecture of the foot bones 336 Taking In the Ankle and Foot Joints 337 Moving up and down: The ankle joint 337 Supporting your weight: The foot and toe joints 338 Bending Your Ankle and Curling Your Toes: The Muscles 341 Turning to leg muscles that move the ankle and the foot 341 Minding the muscles of the foot 343 Getting Maintenance with Nerves, Blood Vessels, and Lymphatics 344 Naming the nerves 345 Looking at blood vessels and lymphatics 346 Summing Up the Surface Landmarks of the Ankle and the Foot 347 Part V: The Part of Tens 349 Chapter 22: Ten Helpful Clinical Anatomy Mnemonics 351 Thinking about the Cranial Bones 351 Focusing on the Facial Bones 352 Memorizing the Cranial Nerves 352 Summing Up the Heart-Valve Sequence 353 Ordering the Abdominal Muscles 353 Tracking the Intestinal Tract 354 Remembering the Rotator Cuff Muscles 354 Concentrating on the Carpal Bones 354 Looking at the Lateral Rotator Muscles of the Hip 355 Taming the Tarsal Bones 355 Chapter 23: Ten Ways to Look into the Body without Cutting It Open 357 Conventional Radiography 357 Computerized Tomography 358 Magnetic Resonance Imaging 358 Positron Emission Tomography 358 Fluoroscopy 359 Mammography 359 Ultrasonography 359 Opthalmoscopy 360 Upper Endoscopy 360 Colonoscopy 360 Index 361

Read more less

Book SynopsisNanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presentinga thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare,this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology and bioimaging Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference With a multidisciplinary approach and aTable of ContentsContributors ix PREFACE xiii Acknowledgments xix 1 Historical Perspective on Nanoparticles in Imaging from 1895 to 2000 1Mikhail Y. Berezin Part I Nanoparticle design, synthesis and characterization 25 2 Iron Oxide-Based Magnetic Nanoparticles Synthesized from the Organic Solution Phase for Advanced Biological Imaging 27Sen Zhang and Shouheng Sun 3 Lipid-Based Pharmaceutical Nanocarriers for Imaging Applications 49Tamer Elbayoumi and Vladimir Torchilin 4 Hollow Nanocapsules in Biomedical Imaging Applications 83Sergey A. Dergunov and Eugene Pinkhassik 5 Nanoparticles as Contrast Agents for Optoacoustic Imaging 111Anton V. Liopo and Alexander A. Oraevsky 6 Nanoparticles for Bioimaging: Analytical Characterization and Measurements 151Kate Nelson, Patrick Winter, Monica Shokeen, Steven Wang, and Mikhail Y. Berezin Part II Imaging modalities: from concepts to applications 193 7 Radio-Labeled Nanoparticles for Biomedical Imaging 195Tolulope Aweda, Deborah Sultan, and Yongjian Liu 8 MRI with Gadolinium-Based Nanoparticles 223François Guérard, Geoffrey L. Ray, and Martin W. Brechbiel 9 In Vivo Molecular Fluorescence Imaging 263Yasaman Ardeshirpour, Victor Chernomordik, Moinuddin Hassan, Dan Sackett, and Amir H. Gandjbakhche 10 Photoacoustic and Ultrasound Imaging with Nanosized Contrast Agents 293Mansik Jeon and Chulhong Kim 11 Surface-Enhanced Raman Scattering-Based Bioimaging 325Limei Tian and Srikanth Singamaneni Part III Nanotechnology in biomedical imaging and beyond 347 12 Pandia®: Gold Nanorods and their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and their Potential Application to Humans 349Christian Schoen and Cheryl London 13 Imaging Genetic Information 373John-Stephen Taylor 14 The Application of Plant Viral Nanoparticles in Tissue-Specific Imaging 401Amy M. Wen, Choi-Fong Cho, John D. Lewis, and Nicole F. Steinmetz 15 Design and Development of Theranostic Nanomedicines 429Jelena M. Janjic and Mingfeng Bai 16 Animal Models for Preclinical Imaging 467Grayson Talcott and Walter J. Akers Index 487

Read more less

Book SynopsisA guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team oTable of ContentsEditors vi Contributors vii Introduction ix 1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1Saranya Chumsri and Keith L. Knutson 2 Monoclonal Antibody Therapy 12Elizabeth A. Mittendorf and Sabitha Prabhakaran 3 Somatic Mutations and Immunotherapy 24Eric Tran 4 Checkpoint Blockade 37Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder 5 Myeloid Leukemia Vaccines 54Paul M. Armistead and Jonathan S. Serody 6 Cancer Vaccines for Solid Tumors 72Timothy J. Vreeland Garth S. Herbert and George E. Peoples 7 Immunotherapy with Non–Genetically Modified T Cells 91Cassian Yee 8 Immunotherapy with Genetically Modified T Cells 101Liora Schultz and Crystal Mackall 9 Immunomodulation with Adjuvants and Cytokines 115Dae won Kim and Adi Diab 10 Immune Cell Migration in Cancer and Immunotherapy 132Timothy Murray and Daniel E. Speiser 11 Repurposing of Drugs for Immunotherapy 143Jyothishmathi Swaminathan and Vidya Gopalakrishnan 12 Immunomodulation with Radiation 161Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh 13 Good Manufacturing Practices Facilities for Cellular Therapy 177Andrew D. Fesnak and Bruce L. Levine 14 T Cell Receptor Mimic Antibodies 186Gheath Alatrash and Jeffrey J. Molldrem 15 Stem Cell Transplantation for Treatment of Malignancy 201Lohith S. Bachegowda and Richard E. Champlin 16 Natural Killer Cell–Based Immunotherapy 215Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee 17 Immunologic Monitoring in Immuno‐Oncology 228William R. Gwin and Mary L. Disis 18 Cell‐Based Therapies for Canine Cancer 252Nicola J. Mason and M. Kazim Panjwani 19 Interaction between Targeted Therapy and Immunotherapy 268Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo Index 286

Read more less

Book SynopsisBone Marrow Diagnosis, Third Edition, is an essential resource for pathologists and haematologists who need to report bone marrow trephine biopsies. Practical and highly illustrated this edition has been comprehensively updated whilst remaining succinct and concentrating on the core information necessary to make an accurate diagnosis. The text provides comparisons of the common methods of sample collection, fixation and staining, and a clear description of how to examine a trephine section. Applying a consistent approach, the chapters cover the range of disorders of bone marrow, discussing the clinical features, histopathology of bone marrow and diagnostic problems of each condition. Each chapter closes with a summary of key points and each diagnostic entity is accompanied by high quality images, over 900 in all, showing typical and more unusual examples of histological features. This compact text, oriented at diagnosis and comprehensively accompanied by Table of ContentsPreface to the third edition vi Preface to the first edition vii 1 Introduction 1 2 The normal bone marrow 4 3 Infections including human immunodeficiency virus 18 4 Anaemias and aplasias 32 5 The myelodysplastic syndromes 42 6 Myeloproliferative neoplasms 49 7 Acute leukaemia 69 8 Lymphomas: an overview 89 9 Precursor B and T lymphoblastic leukaemia (acute lymphoblastic leukaemia) and lymphoblastic lymphoma 101 10 Mature B cell neoplasms 108 11 Mature T and NK cell neoplasms 161 12 Hodgkin lymphoma 179 13 Metastatic disease 188 14 Bone stroma and miscellaneous changes 196 15 Technical considerations 209 Index 215

Read more less

Book SynopsisIssues of thrombosis, bleeding, and transfusion are extremely common, and often complex, in critically ill patients. Haematology in Critical Care: A Practical Handbookprovidesa dependable source of expert guidance on how to handle common haematological problems seen in the critical care setting, as well as the acute care of patients with a primary haematological disorder. Full-time clinical haematologists, regularly attending on intensive care, the Editors begin with an approach to abnormal laboratory tests, following with a disease-orientated approach to topics such as coagulation and haematological malignancy. Other key topics include paediatric and neonatal care, transfusion, point of care testing and the emergency presentation of haematological disease. This title brings together two of the most highly scientific specialties in clinical practice, delivering a practical approach to these problems, and guiding the clinician through the diagnosis Table of ContentsList of Contributors, v Preface, ix Acknowledgements, x Section 1 Approach to Abnormal Blood Tests 1 Diagnostic Approach to Anaemia in Critical Care, 3Stephen F. Hawkins and Quentin A. Hill 2 Leukopenia, 9Stephen F. Hawkins, Jecko Thachil and Quentin A. Hill 3 Thrombocytopenia in the Intensive Care Unit, 12Jecko Thachil 4 High Blood Counts, 16Quentin A. Hill 5 The Abnormal Clotting Profile, 26Jecko Thachil 6 Understanding the Blood Film, 31Stephen F. Hawkins and Quentin A. Hill Section 2 Approach to Coagulation Problems 7 Venous Thromboembolism in Intensive Care, 39Sarah A. Bennett and Roopen Arya 8 Reversal and Monitoring of Anticoagulants, 45Joost J. van Veen 9 Disseminated Intravascular Coagulation, 52Jecko Thachil 10 Heparin-Induced Thrombocytopenia, 58Jerrold H. Levy and Anne M. Winkler 11 Thrombotic Microangiopathies, 62Mari Thomas and Marie Scully 12 Critical Care of Patients with a Congenital Bleeding Disorder, 69Vanessa Martlew Section 3 Approach to Transfusion Problems 13 Blood Components and Their Contents, 77Shubha Allard 14 Transfusion Reactions, 86Therese A. Callaghan 15 The Management of Non-traumatic Massive Haemorrhage, 93Nicola S. Curry and Simon J. Stanworth 16 Plasma Exchange, 100Khaled El-Ghariani Section 4 Approach to Red Cell Problems 17 Appropriate Haemoglobin in Intensive Care, 107Jonathan Wallis and Stephen Wright 18 Sickle Cell Disease and Thalassaemia in the Critical Care Setting, 112Andrew Retter and Jo Howard 19 Management of Patients Who Refuse Blood Transfusion, 118Derek R. Norfolk and Fran Hartley Section 5 Approach to White Cell Problems 20 Infectious Complications in the Immunosuppressed Patient, 125Tim Collyns and Elankumaran Paramasivam 21 Haematopoietic Stem Cell Transplantation (HSCT), 135John Snowden and Stephen Webber 22 Multiple Myeloma and Hyperviscosity Syndrome, 144Amin Rahemtulla and Joydeep Chakrabartty, 23 Palliative Care for the Patient with Haematological Malignancy in Intensive Care, 148Suzanne Kite Section 6 Admission to Intensive Care 24 Haematological Malignancy Outside Intensive Care: Current Practice and Outcomes, 159Charlotte Kallmeyer 25 Early Care of the Unstable Patient: Preventing Admission to the Intensive Care Unit, 165Andrew Breen 26 Decisions to Intensify Treatment: Who Will Benefit from Intensive Care?, 171Quentin A. Hill and Peter A. Hampshire Section 7 Point-of-Care Testing 27 The Relevance of Thromboelastography in Intensive Care Patients, 179Jon Bailey and Nicola S. Curry Section 8 Haematology Drugs in Critical Care 28 Recombinant Activated Coagulation Factor VII (rFVIIa) in Critical Care, 187Leon Cloherty and Richard Wenstone 29 The Use of Haemostatic Drugs in Post-operative Bleeding, 192Catharina Hartman and Nigel Webster 30 Delivering Chemotherapy on Intensive Care, 196Arvind Arumainathan and Daniel Collins Section 9 Haematology in Paediatric and Neonatal Intensive Care 31 Neonatal Anaemia, 207Michael Richards 32 Haemolysis, 213Michael Richards 33 Approach to Thrombocytopenia, 219Amrana Qureshi 34 Blood Component Therapy in Children and Neonates, 224Anne Kelly, Simon J. Stanworth and Helen V. New Section 10 Haematological Emergencies 35 Haematological Emergencies, 235Quentin A. Hill and Amin Rahemtulla Appendix A: Adult, Paediatric and Neonatal Haematology Reference Intervals, 243Quentin A. Hill Index, 249

Read more less

Book SynopsisHuman factors relates to the interaction of humans and technical systems. Human factors engineering analyzes tasks, considering the components in relation to a number of factors focusing particularly on human interactions and the interface between people working within systems. This book will help instructors teach the topic of human factors.Trade Review“Though pocket-sized, this guide offers a lot, drawing attention to the challenges and opportunities created by human factors in healthcare. Its objectives are clear, coverage broad, and advice informed and practical. It achieves its purpose and is recommended.” (Doody’s, 3 January 2014)Table of ContentsWorking group, vi Contributors, vii Foreword, viii Preface, ix Acknowledgements, xii Contact details and further information, xiii Chapter 1 Introduction to human factors in medicine, 1 Chapter 2 Human cognition and error, 10 Chapter 3 Situation awareness, 20 Chapter 4 Leadership and teamworking, 28 Chapter 5 Personality and behaviour, 36 Chapter 6 Communication and assertiveness, 42 Chapter 7 Decision making, 51 Chapter 8 Fatigue and stress, 61 Chapter 9 Key elements in communication: briefing and debriefing, 71 Chapter 10 Organisational culture, 79 Chapter 11 Guidelines, checklists and protocols, 85 Anthology, 91 Index, 97

Read more less