Description
Book SynopsisOffering a holistic view of the development of drug delivery systems, Advanced Drug Delivery presents the essential aspects necessary to understand and apply for effective drug delivery fundamentals, including practical issues, integration of pharmaceutics, and molecular biology.
Trade Review“This book is a welcome addition to the range of study materials available at this level and can be unreservedly recommended to both aspiring and existing pharmaceutical professionals.” (ChemMedChem, 1 January 2015)
“A suitable text for graduate and advanced undergraduate students, the book is logically divided into four sections: fundamentals, delivery approaches, disease applications, and future directions. Discussing design, in vitro studies, clinical evaluation, and regulatory approval, each chapter includes objectives and assessment questions.” (Newbooks.lib, 11 September 2014
Table of ContentsPREFACE xi
ABOUT THE AUTHORS xiii
CONTRIBUTORS xv
PART I INTRODUCTION AND BASICS OF ADVANCED DRUG DELIVERY 1
1 Physiological Barriers in Advanced Drug Delivery: Gastrointestinal Barrier 3
D. Alexander Oh and Chi H. Lee
2 Solubility and Stability Aspects in Advanced Drug Delivery 21
Hoo-Kyun Choi, Robhash K. Subedi, and Chi H. Lee
3 The Role of Transporters and the Efflux System in Drug Delivery 47
Varun Khurana, Dhananjay Pal, Mukul Minocha, and Ashim K. Mitra
4 Biomaterial in Advanced Drug Delivery 75
Megha Barot, Mitesh Patel, Xiaoyan Yang, Wuchen Wang, and Chi H. Lee
PART II STRATEGIES FOR ADVANCED DRUG DELIVERY 103
5 Strategies of Drug Targeting 105
Ravi S. Shukla, Zhijin Chen, and Kun Cheng
6 Prodrug and Bioconjugation 123
Ramya Krishna Vadlapatla, Sujay Shah, Aswani Dutt Vadlapudi, and Ashim K. Mitra
7 Nanoscale Drug Delivery Systems 141
Mitan R. Gokulgandhi, Ashaben Patel, Kishore Cholkar, Megha Barot, and Ashim K. Mitra
8 Stimuli-Responsive Target Strategies 157
Chi H. Lee
9 Implants 183
Aswani Dutt Vadlapudi, Ashaben Patel, Ramya Krishna Vadlapatla, Durga Paturi, and Ashim K. Mitra
10 Aptamers in Advanced Drug Delivery 201
Weiwei Gao, Omid C. Farokhzad, and Nazila Kamaly
11 Nanofiber 219
Megha Barot, Mitan R. Gokulgandhi, Animikh Ray, and Ashim K. Mitra
12 Biomimetic Self-Assembling Nanoparticles 231
Maxim G. Ryadnov
13 Protein and Peptide Drug Delivery 241
Mitesh Patel, Megha Barot, Jwala Renukuntla, and Ashim K. Mitra
14 Delivery of Nucleic Acids 257
Shaoying Wang, Bin Qin, and Kun Cheng
15 Delivery of Vaccines 275
Hari R. Desu, Rubi Mahato, and Laura A. Thoma
PART III TRANSLATIONAL RESEARCH OF ADVANCED DRUG DELIVERY 297
16 Regulatory Considerations and Clinical Issues in Advanced Drug Delivery 299
Mei-Ling Chen
17 Advanced Drug Delivery in Cancer Therapy 323
Wanyi Tai and Kun Cheng
18 Advanced Delivery in Cardiovascular Diseases 341
Gayathri Acharya, Wuchen Wang, Divya Teja Vavilala, Mridul Mukherji, and Chi H. Lee
19 Recent Advances in Ocular Drug Delivery 365
Varun Khurana, Deep Kwatra, Vibhuti Agrahari, and Ashim K. Mitra
20 Advanced Drug Delivery Against STD 381
Chi H. Lee
21 Advanced Drug Delivery to the Brain 405
Nanda K. Mandava, Mitesh Patel, and Ashim K. Mitra
PART IV FUTURE APPLICATIONS OF ADVANCED DRUG DELIVERY IN EMERGING RESEARCH AREAS 423
22 Cell-Based Therapeutics 425
Zhaoyang Ye, Yan Zhou, Haibo Cai, and Wen-Song Tan
23 Biomedical Applications and Tissue Engineering of Collagen 445
Chi H. Lee and Yugyung Lee
24 Molecular Imaging of Drug Delivery 469
Zheng-Rong Lu
ANSWERS 489
INDEX 511
