Clinical and internal medicine Books
John Wiley and Sons Ltd The Respiratory System at a Glance
Book SynopsisThe Respiratory System at a Glance The market-leading at a Glance series is popular among healthcare students and newly qualified practitioners for its concise, simple approach and excellent illustrations. Each bite-sized chapter is covered in a double-page spread with clear, easy-to-follow diagrams, supported by succinct explanatory text. Covering a wide range of topics, books in the at a Glance series are ideal as introductory texts for teaching, learning and revision, and are useful throughout university and beyond. Everything you need to know about The Respiratory System at a Glance! Highly-illustrated overview of the structure and function of the lungs and airways, with sections on history, examination, pathophysiology, treatment and management Respiratory System at a Glance is a comprehensive guide to normal lung structure and function and associated pathophysiology, featuring key information on all major respiratory disorders. As per the familiar, easy-to-use at a Glance' format, each topic is presented as a double-page spread, with key facts accompanied by clear diagrams that encapsulate essential knowledge. This one-stop' resource has been revised and updated for this 5thedition to include recent advances in our understanding and/or treatment of asthma, COPD, pulmonary vasculitis, sarcoidosis, cystic fibrosis, respiratory infections (including COVID-19), and the most recent national clinical management guidelines. The accompanying website includes self-assessment case studies, flashcards and MCQs to support learning or for review. Respiratory System at a Glance also provides information on: Structure and function of the respiratory system, the thoracic cage and respiratory muscles, gas laws, diffusion, and elastic forcesAcid-base balance and disorders, control of breathing through chemical and neural mechanisms, and pulmonary circulation and ventilation-perfusion matchingExercise, altitude, and diving, complications of development and congenital disease, lung defense mechanisms, and immunology of the lungs Public health and smoking, respiratory failure, and the pathophysiology and management of asthma, chronic obstructive pulmonary disease and other respiratory disorders With accompanying self-assessment clinical cases and multiple-choice questions, The Respiratory System at a Glance is the ideal companion for anyone about to start a respiratory module or rotation, and will appeal to medical students and junior doctors, as well as nurses, dentists, physiotherapists, technicians, and biomedical scientists. For more information on the complete range of Wiley nursing and health publishing, please visit: www.wiley.com To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email All content reviewed by students for students Wiley Medical Education books are designed exactly for their intended audience. All of our books are developed in collaboration with students. This means that our books are always published with you, the student, in mind. If you would like to be one of our student reviewers, go to www.reviewmedicalbooks.com to find out more. This new edition is also available as an e-book. For more details, please see www.wiley.comTable of ContentsPreface to Fifth Edition vii Units and Symbols viii Abbreviations x Glossary xiii About the companion website xvi Part 1 Structure and function 1 1 Structure of the respiratory system: lungs, airways and dead space 2 2 The thoracic cage and respiratory muscles 4 3 Pressures and volumes during normal breathing 6 4 Gas laws 8 5 Diffusion 10 6 Lung mechanics: elastic forces 12 7 Lung mechanics: airway resistance 14 8 Carriage of oxygen 16 9 Carriage of carbon dioxide 18 10 Acid–base balance 20 11 Acid–base disorders 22 12 Control of breathing I: chemical mechanisms 24 13 Control of breathing II: neural mechanisms 26 14 Pulmonary circulation and anatomical right- to- left shunts 28 15 Ventilation–perfusion mismatching 30 16 Exercise, high altitude and diving 32 17 Development of the respiratory system and birth 34 18 Complications of development and congenital disease 36 19 Lung defence mechanisms 38 20 Immunology of the lung 40 Part 2 History, examination and investigation 43 21 History and examination 44 22 Pulmonary function tests 46 23 Chest imaging and bronchoscopy 48 Part 3 Diseases and treatment 51 24 Public health and smoking 52 25 Respiratory failure 54 26 Asthma: pathophysiology 56 27 Asthma: treatment 58 28 Chronic obstructive pulmonary disease 60 29 Pulmonary hypertension 62 30 Venous thromboembolism and pulmonary embolism 64 31 Pulmonary vasculitis 66 32 Interstitial (diffuse parenchymal) lung disease 68 33 Sarcoidosis 70 34 Pleural diseases 72 35 Occupational and environment- related lung disease 74 36 Cystic fibrosis and bronchiectasis 76 37 Pneumothorax 78 38 Community- acquired pneumonia 80 39 Hospital- acquired (nosocomial) pneumonia 82 40 Pulmonary tuberculosis 84 41 The immune- compromised patient 86 42 Lung cancer 88 43 Acute respiratory distress syndrome 90 44 Mechanical ventilation 92 45 Oxygenation and oxygen therapy 94 46 Sleep disordered breathing 96 47 Coronavirus disease 2019 98 Index 100
£29.40
Wiley-Blackwell Diagnostic Imaging and Anatomy in Acute Care
Book Synopsis
£37.99
Wiley-Blackwell Echocardiography Board Review 600 Multiple
Book Synopsis
£56.99
John Wiley and Sons Ltd Dermatopathology
Book SynopsisDermatopathology The most up-to-date edition of a pattern-based dermatopathology atlas In Dermatopathology: Diagnosis by First Impression, an expert team of dermatopathologists deliver an authoritative guide to the microscopic differentiation of visually similar dermatological diseases that is useful for both trainees and practicing physicians. This latest fourth edition includes new sections on alopecia and immunohistochemistry as well as over 100 new photomicrographs for a total of almost 1000 high-resolution and annotated figures. The Key Differences pages walk the reader through the identification of distinctive diagnostic features, and disease-based and alphabetical indexes make it simple to quickly locate necessary information. Unique amongst dermatopathology atlases, this book remains organized by microscopic pattern???as opposed to disease category???which makes it the perfect companion for slide analysis. It also offers self-assessment questions and algorithms for pattern analysis, as well as: An introduction to gestalt diagnosis Focus on architectural patterns as well as cell type/morphology Practical discussion of immunohistochemistry Expanded sections on melanocytic, soft tissue, and lymphoid lesions as well as alopecia A visual feast for practicing dermatologists and pathologists, Dermatopathology: Diagnosis by First Impression will also earn a place in the libraries of trainees.Table of ContentsPreface, viii Acknowledgments, ix About the Companion Website, xi Introduction, 1 Chapter 1 Shape on Low Power, 23 Epidermis Regular acanthosis, 25 Lobular proliferation, 29 Reticulated proliferation, 35 Central pore, 42 Epidermal perforation, 46 Dermis Circular islands, 49 Cords/tubules and comma shapes, 53 Space with a lining, 59 Papillations, 70 Polypoid (dome-shaped), 77 Square/rectangular, 82 Palisading reactions, 88 Pseudoepitheliomatous hyperplasia above abscesses, 95 Pink ball, (see Chapter 6) Chapter 2 Gestalt: Rash/inflammatory, 99 Epidermal changes Parakeratosis, 101 Spongiosis, 104 Papulosquamous (psoriasiform), 108 Interface (vacuolar), 114 Interface (lichenoid), 119 Inflammation: Specific patterns and cell type Epidermal eosinophils, 125 Perivascular, 129 Band-like dermal/papillary dermal infiltrate, 133 Diffuse/nodular, 139 Subcutaneous, 146 Chapter 3 Cell Type, 153 Melanocytic, 155 Spindle cells, 168 Pleomorphic cells, 186 Epithelioid vs spindle vs pleomorphic cells, 187 Endothelial, 188 Giant, 202 Clear, 212 Chapter 4 Top-Down, 229 Arthropods, 231 Hyperkeratosis/parakeratosis, 237 Upper epidermal change, 244 Acantholysis, 254 Subepidermal space/cleft, 264 Granular “material” in cells, 271 “Busy” dermis, 276 Dermal material, 279 Fat necrosis, 292 Chapter 5 Color – Blue, 295 Blue tumor, 297 Lymphocytes, 307 Mucin and glands or ducts, 315 Mucin, 319 Chapter 6 Color – Pink, 327 Pink ball of spindle cells, 329 Pink material, 332 Pink dermis, 339 Epidermal necrosis, 341 Chapter 7 Miscellaneous, 347 Alopecia, 349 Immunohistochemistry, 354 Index (Pattern), 361 Index (Histological Category), 366 Index (Alphabetical), 369
£93.56
John Wiley and Sons Ltd Training to Change Practice
Book SynopsisTable of ContentsContents Foreword ix Acknowledgements xi CHAPTER 1 Education and Training as a Behaviour Change Intervention 1 Jo Hart, Lucie Byrne-Davis, Wendy Maltinsky, Eleanor Bull, Nicola McCleary and Chris Armitage What Is Continuing Professional Development? 2 The Purpose(s) of CPD 2 The Challenges of Changing Practice through CPD 3 Important Concepts and Theories 4 Miller’s Pyramid 4 Figure 1: The interaction of capability, opportunity, motivation and Miller’s Pyramid 5 A Shared Theoretical Language 6 Why Think about Behavioural Theory? 7 The COM-B Framework 8 Figure 2: Influences on behaviour mapped to capability, opportunity and motivation 8 A Focus on Motivation 9 Why Is Behavioural Science Important? 10 Effective and Enjoyable Training 10 Principles for Effective Training 11 Principle 1. Starting from Where Learners Are 11 Principle 2. Working in Partnership 11 Principle 3. Interactive/Active Learning 12 Principle 4. Communication 13 Principle 5. A Collaborative Learning Environment 13 Principle 6. Individual and Group Voices 14 Principle 7. Time for Reflection 15 Check Your Understanding and Reflect 15 Useful Links and Further Reading 16 Behavioural theories and types of behaviours 16 Dual processing 16 The COM-B Framework 16 PRIME Theory and other briefings on behaviour change 16 References 16 CHAPTER 2 Defining the Behaviours That You Want to Change 20 Jo Hart, Lucie Byrne-Davis, Wendy Maltinsky and Eleanor Bull Introduction 21 Developing a Theory of Change 22 Tips and examples 22 Intended Behavioural Outcomes (IBOs) 23 Tips and examples 24 How to Develop IBOs 24 Tips and examples: Topic guide and cues for a behavioural specification focus group 26 What Does the Evidence Say? 26 Choosing the IBOs on Which to Focus 27 Whose IBOs Are They? 27 Check Your Understanding 28 Useful Links and Further Reading 28 Developing A Theory of Change 28 References 29 CHAPTER 3 Exploring the Influences on Behaviours 30 Jo Hart, Lucie Byrne-Davis, Wendy Maltinsky and Eleanor Bull Influences on Practice 31 Figure 3: The COM-B framework 31 Capability 31 Tips and examples 31 Opportunity 31 Tips and examples 32 Motivation 32 Tips and examples 32 How to Explore Influences on Each IBO 32 Before Developing CPD 33 Tips and examples 33 Tips and examples 35 During CPD 35 Check Your Understanding and Reflect 36 Further Reading 36 More About Exploring Influences on Behaviour 36 References 36 CHAPTER 4 Developing CPD to Change Behaviour 38 Jo Hart, Lucie Byrne-Davis, Wendy Maltinsky and Eleanor Bull The Active Ingredients of Behaviour Change Activities 39 Reminder: What is COM-B Again? 39 BCTs and Communication Skills in Education and Training 40 Tips and examples 40 How to Develop Your Training Activities 41 Capability 44 What Does the Evidence Say? 45 Figure 4: The Johari Window 45 Tips and examples 45 Figure 5: Post-it notes to illustrate an effective practitioner 46 Building Psychological Capability 47 Tips and examples 47 Building Physical Capability 48 Figure 6: A cycle for physical capability improvement (learning a skill) 49 Tips and examples 49 Opportunity 50 Building Physical Opportunity 50 Tips and examples 51 An Appreciative Inquiry Approach 52 Building Social Opportunity 52 Tips and examples 53 Tips and examples 53 Figure 7: Comic book strip 54 Motivation 55 Building Reflective Motivation 55 Tips and examples 56 Building Automatic Motivation 56 Tips and examples 57 Planning the ‘How’ of Your Training 57 Consider Space 57 Consider Numbers 58 Consider Acoustics and Visuals 58 Consider Time 58 Consider Dynamics 58 Consider Technical Equipment and Skills 59 Consider Administrative Support 59 Consider Refreshments 59 Consider Culture/Contexts/Countries 59 Online 60 Blended Learning – Synchronous and Asynchronous 61 Figure 8: Considerations for a blending learning course 62 The Building Blocks of Your Training 63 Figure 9: Overview of training structure 63 Introductions 63 Welcoming 63 Introductory Activities 64 Trainee Introductions 64 Create Name-Plates 64 Introductory Bingo 65 Introduce Your Neighbour 65 Throw the Soft Toy 65 Group Agreements 65 Course Expectations, Hopes and Fears 66 Balancing Training Energy 66 Endings: Reflection, Action Planning and Evaluation 67 Check Your Understanding and Reflect 67 Further Reading 68 References 68 CHAPTER 5 Assessing and Evaluating 70 Jo Hart, Lucie Byrne-Davis, Wendy Maltinsky and Eleanor Bull Process vs. Outcome 71 Why Are You Evaluating? 72 Theories and Frameworks to Help Us Evaluate 72 The Kirkpatrick Model 73 Tips and examples 73 Evaluation of Complex Interventions 74 Assessing Behavioural Influences 75 Topic guide 76 Figure 10: Topic guide example for interviews about the impact of a course on practice at follow-up 76 Assessing Behaviour 78 Check Your Understanding 79 Further Reading 79 References 80 Guides 81 Sample Training Plans 81 Aims 88 Tips and Examples: Setting up A Session 88 Cards for Change 94 Index 111
£33.24
John Wiley and Sons Ltd Personcentred Care in Radiography
Book SynopsisPERSON-CENTRED CARE IN RADIOGRAPHY A helpful guide to patient and person-centered care in radiography, with a particular focus on interpersonal and communication skills Person-centred Care in Radiography: Skills for Providing Effective Patient Care explores the complex interpersonal skills that are required of practitioners and medical imaging professionals which ensure high-quality service is given to person-centred care in radiography. The textbook is also written by a team of expert authors, and grounded in the team's own research, as well as their involvement with the Heads of Radiography Group, the Association of Radiography Educators, the Collaborating Centre for Values-based Practice in Health and Social Care, and the College of Radiographers. The textbook contains a broad range of additional learning features, including case studies, student exercises, annotated further readings, and chapter summaries. Diagrams and illustrations are used throughout the book to provide visual representation of the concepts presented. Learning activities are also included throughout the book to encourage readers to self-discover and reflect and then apply their learning to their own role. Person-centred Care in Radiography includes detailed information on and discussion of: Values, developing resilience, defining compassion, pain and suffering, and professional behaviors and cultureScenarios developed by service users based on real-life practice, to demonstrate the impact of the professional's behavior on the care receivedDiversity of service users, the role of carers, conceptual frameworks, interpersonal communication skills and communicating with patients beyond introductionsValues-based practice, compassionate practice, theoretical models for patient-centered care in radiography and reflections to help readers move forward Targeted at all staff working within diagnostic and therapeutic radiography clinical departments and educational institutions, Person-centred Care in Radiography, can be used in both radiography education by students and educators and by qualified staff who wish to reflect on their own patient care and develop their skills.Table of ContentsList of Contributors v Chapter 1 Introduction 1 Ruth M. Strudwick and Emma Hyde Section I Understanding Ourselves 7 Chapter 2 Exploration of Your Own Values 9 Ruth M. Strudwick, Ann Newton-Hughes, and Jane M. Harvey-Lloyd Chapter 3 Developing Resilience 16 Jane M. Harvey-Lloyd Chapter 4 What Is Compassion? 24 Amy Hancock, Jane Gooch, and Jill Bleiker Chapter 5 Pain and Suffering 34 Ann Newton-Hughes, Amy Hancock, and Jill Bleiker Chapter 6 Professional Behaviours and Culture 46 Ruth M. Strudwick and Amy Hancock Section II Understanding the Service User 59 Chapter 7 Diversity of Service Users 61 Jane M. Harvey-Lloyd, Jane Gooch, and Ruth M. Strudwick Chapter 8 The Role of Carers 68 Jane M. Harvey-Lloyd and Ruth M. Strudwick Chapter 9 A Conceptual Framework for Understanding Compassion in Radiography 73 Amy Hancock and Jill Bleiker Chapter 10 Interpersonal Communication Skills 82 Jane M. Harvey-Lloyd and Emma Hyde Chapter 11 Is There More to Communicating with Patients than #Hellomynameis? 94 Jane Gooch Chapter 12 Values-Based Practice 101 Ruth M. Strudwick and Ann Newton-Hughes Chapter 13 Compassion in Practice 109 Amy Hancock and Jill Bleiker Chapter 14 Theoretical Models for Person-centred Care in Radiography 124 Emma Hyde Chapter 15 Reflection on the Books and Skills Learned 137 Ruth M. Strudwick Appendix A Organisational Measures of Patient Centred Care in Imaging Departments 139 Appendix B Pause and Check Audit Tool for Measuring Patient-Centred Care in Diagnostic Radiography (for use in Projection Radiography, Including Mammography) 144 Index 151
£35.14
Wiley-Blackwell Critical Care Manual of Clinical Nursing
Book Synopsis
£42.74
John Wiley & Sons Inc Biochemistry For Dummies
Book SynopsisTable of ContentsIntroduction 1 About This Book 1 Foolish Assumptions 2 Icons Used in This Book 3 Beyond the Book 3 Where to Go from Here 4 Part 1: Setting the Stage: Basic Biochemistry Concepts 5 Chapter 1: Biochemistry: What You Need to Know and Why 7 Why Biochemistry? 7 What Is Biochemistry and Where Does It Take Place? 8 Types of Living Cells 8 Prokaryotes 9 Eukaryotes 9 Animal Cells and How They Work 10 A Brief Look at Plant Cells 12 Chapter 2: Seems So Basic: Water Chemistry and pH 15 The Fundamentals of H2O 16 Let’s get wet! The physical properties of water 16 Water’s most important biochemical role: The solvent 18 Hydrogen Ion Concentration: Acids and Bases 20 Achieving equilibrium 20 Understanding the pH scale 21 Calculating pOH 23 Applying the Brønsted-Lowry theory 23 Buffers and pH Control 27 Identifying common physiological buffers 27 Calculating a buffer’s pH 28 Chapter 3: Fun with Carbon: Organic Chemistry 31 The Role of Carbon in the Study of Life 31 It’s All in the Numbers: Carbon Bonds 33 When Forces Attract: Bond Strengths 33 Everybody has ‘em: Intermolecular forces 34 Water-related interactions: Both the lovers and the haters 35 How bond strengths affect physical properties of substances 35 Getting a Reaction out of a Molecule: Functional Groups 37 Hydrocarbons 37 Functional groups with oxygen and sulfur 37 Functional groups containing nitrogen 38 Functional groups containing phosphorus 39 Reactions of functional groups 40 pH and functional groups 43 Same Content, Different Structure: Isomerism 44 Cis-trans isomers 44 Chiral carbons 44 Part 2: The Meat of Biochemistry: Proteins 47 Chapter 4: Amino Acids: The Building Blocks of Protein 49 General Properties of Amino Acids 50 Amino acids are positive and negative: The zwitterion formation 50 Protonated? pH and the isoelectric point 51 Asymmetry: Chiral amino acids 52 The Magic 20 Amino Acids 53 Nonpolar (hydrophobic) and uncharged amino acids 53 Polar (hydrophilic) and uncharged amino acids 55 Acidic amino acids 57 Basic amino acids 57 Lest We Forget: Rarer Amino Acids 58 Rudiments of Amino Acid Interactions 59 Intermolecular forces: How an amino acid interacts with other molecules 59 Altering interactions by changing the pH 61 Combining Amino Acids: How It Works 62 The peptide bond and the dipeptide 63 Tripeptide: Adding an amino acid to a dipeptide 64 Chapter 5: Protein Structure and Function 65 Proteins: Not Just for Dinner 65 Primary Structure: The Structure Level All Proteins Have 67 Building a protein: Outlining the process 67 Organizing the amino acids 68 Example: The primary structure of insulin 69 Secondary Structure: A Structure Level Most Proteins Have 69 The -helix 70 The -pleated sheet 71 -turns and the -loops 73 Tertiary Structure: A Structure Level Many Proteins Have 74 Quaternary Structure: A Structure Level Some Proteins Have 75 Dissecting a Protein for Study 75 Separating proteins within a cell and purifying them 75 Digging into the details: Uncovering a protein’s amino acid sequence 78 Chapter 6: Enzyme Kinetics: Getting There Faster 83 Enzyme Classification: The Best Catalyst for the Job 84 Up one, down one: Oxidoreductases 85 You don’t belong here: Transferases 86 Water does it again: Hydrolases 86 Taking it apart: Lyases 87 Shuffling the deck: Isomerases 87 Putting it together: Ligases 87 Enzymes as Catalysts: When Fast Is Not Fast Enough 88 All about Kinetics 90 Enzyme assays: Fixed time and kinetics 91 Rate determination: How fast is fast? 92 Measuring Enzyme Behavior: The Michaelis-Menten Equation 94 Ideal applications 97 Realistic applications 98 Here we go again: Lineweaver-Burk plots 98 Graphing kinetics data 100 Enzyme Inhibition: Slowing It Down 102 Competitive inhibition 102 Noncompetitive inhibition 103 Graphing inhibition 103 Enzyme Regulation 104 Part 3: Carbohydrates, Lipids, Nucleic Acids, and More, Oh My! 107 Chapter 7: What We Crave: Carbohydrates 109 Properties of Carbohydrates 110 They contain one or more chiral carbons 110 They have multiple chiral centers 111 A Sweet Topic: Monosaccharides 113 The most stable monosaccharide structures: Pyranose and furanose forms 113 Chemical properties of monosaccharides 115 Derivatives of monosaccharides 117 The most common monosaccharides 119 The beginning of life: Ribose and deoxyribose 120 Sugars Joining Hands: Oligosaccharides 120 Keeping it simple: Disaccharides 121 Starch and cellulose: Polysaccharides 124 The Aldose Family of Sugars 126 Chapter 8: Lipids and Membranes 129 Lovely Lipids: An Overview 129 Behavior of lipids 130 Fatty acids in lipids 131 A Fatty Subject: Triglycerides 132 Properties and structures of fats 132 Cleaning up: Breaking down a triglyceride 134 No Simpletons Here: Complex Lipids 134 Phosphoglycerides 135 Sphingolipids 137 Sphingophospholipids 137 Membranes: The Bipolar and the Bilayer 138 Crossing the wall: Membrane transport 139 Steroids: Pumping up 142 Prostaglandins, Thromboxanes, and Leukotrienes: Mopping Up 143 Chapter 9: Nucleic Acids and the Code of Life 145 Nucleotides: The Guts of DNA and RNA 146 Reservoir of genetic info: Nitrogen bases 146 The sweet side of life: The sugars 146 The sour side of life: Phosphoric acid 148 Tracing the Process: From Nucleoside to Nucleotide to Nucleic Acid 148 First reaction: Nitrogen base + 5-carbon sugar = nucleoside 148 Second reaction: Phosphoric acid + nucleoside = nucleotide 149 Third reaction: Nucleotide becomes nucleic acid 150 A Primer on Nucleic Acids 151 DNA and RNA in the grand scheme of life 152 Nucleic acid structure 152 Chapter 10: Vitamins: Both Simple and Complex 155 More than One-a-Day: Basics of Vitamins 156 To B or Not to B: B Complex Vitamins 156 Vitamin B1 (thiamine) 157 Vitamin B2 (riboflavin) 158 Vitamin B3 (niacin) 159 Vitamin B6 (pyridoxine) 160 Biotin 160 Folic acid 162 Pantothenic acid 163 The wonders of vitamin B12 163 Vitamin A 164 Vitamin C 166 Vitamin D 166 Vitamin E 169 Vitamin K 169 Chapter 11: Hormones: The Body’s Messengers 171 Structures of Some Key Hormones 172 Proteins 172 Steroids 173 Amines 174 Now and Later: Prohormones 176 Proinsulin 176 Angiotensinogen 177 Fight or Flight: Hormone Function 177 Opening the letter: Hormonal action 178 Models of hormonal action 179 Part 4: Bioenergetics and Pathways 183 Chapter 12: Life and Energy 185 ATP: The Energy Pony Express 185 ATP and free energy 186 ATP as an energy transporter 187 It’s Relative: Molecules Related to ATP 190 The nucleoside triphosphate family 191 As easy as 1, 2, 3: AMP, ADP, and ATP 193 Where It All Comes From 193 Chapter 13: ATP: The Body’s Monetary System 197 Metabolism I: Glycolysis 198 Glycolysis: Phase I 198 Glycolysis: Phase II 201 Releasing the power: Energy efficiency 202 Going in reverse: Gluconeogenesis 202 Alcoholic fermentation: We’ll drink to that 202 Metabolism II: Citric Acid (Krebs) Cycle 204 Let’s get started: Synthesis of acetyl-CoA 208 Three’s a crowd: Tricarboxylic acids 208 Oxidative decarboxylation 209 Production of succinate and GTP 210 Oxaloacetate regeneration 210 Amino acids as energy sources 211 Electron Transport and Oxidative Phosphorylation 212 The electron transport system 213 Oxidative phosphorylation 218 Proposed mechanisms 221 ATP production 221 Involving the fats: β-oxidation cycle 222 Not so heavenly bodies: Ketone bodies 224 Investing in the Future: Biosynthesis 226 Fatty acids 226 Membrane lipids 229 Amino acids 231 Chapter 14: Smelly Biochemistry: Nitrogen in Biological Systems 237 Ring in the Nitrogen: Purine 237 Biosynthesis of purine 238 How much will it cost? 246 Pyrimidine Synthesis 247 First step: Carbamoyl phosphate 247 Next step: Orotate 247 Last step: Cytidine 250 Back to the Beginning: Catabolism 250 Nucleotide catabolism 251 Amino acid catabolism 251 Heme catabolism 252 Process of Elimination: The Urea Cycle 253 Amino Acids Once Again 256 Metabolic Disorders 257 Gout 257 Lesch-Nyhan syndrome 257 Albinism 258 Alkaptonuria 258 Phenylketonuria 258 Part 5: Genetics: Why We Are What We Are 259 Chapter 15: Photocopying DNA 261 Let’s Do It Again: Replication 262 DNA polymerases 265 The current model of DNA replication 265 Mechanisms of DNA repair 268 Mutation: The good, the bad, and the ugly 270 Restriction enzymes 272 Mendel Rolling Over: Recombinant DNA 272 Patterns: Determining DNA Sequences 273 Getting charged up about gel electrophoresis 274 Determining the base sequence 275 The butler did it: Forensic applications 277 Genetic Diseases and Other DNA Testing Applications 279 Sickle cell anemia 280 Hemochromatosis 280 Cystic fibrosis 280 Hemophilia 281 Tay-Sachs disease 282 Chapter 16: Transcribe This! RNA Transcription 283 Types of RNA 284 RNA Polymerase Requirements 285 Making RNA: The Basics 286 Promoting transcription of RNA 286 Prokaryotic cells 287 Eukaryotic cells 291 Not a Secret Any Longer: The Genetic Code 294 Codons 294 Alpha and omega 296 Models of Gene Regulation 297 The Jacob-Monod (operon) model 298 Regulation of eukaryotic genes 300 Chapter 17: Translation: Protein Synthesis 305 Hopefully Not Lost in Translation 305 Who needs translation, anyway? 305 Home, home in the ribosome 306 The Translation Team 307 The team captain: rRNA 307 Here’s the snap: mRNA 307 Carrying the ball: tRNA 308 Charging up the middle: Amino acid activation 310 Hooking Up: Protein Synthesis 312 Activation 313 Initiation 313 Elongation 314 Termination 315 The wobble hypothesis 315 Variation in Eukaryotic Cells 316 Ribosomes 316 Initiator-tRNA 318 Initiation 319 Elongation and termination 319 Part 6: The Part of Tens 321 Chapter 18: Ten Great Applications of Biochemistry 323 Ames Test 323 Pregnancy Testing 324 HIV Testing 324 Breast Cancer Testing 324 Prenatal Genetic Testing 324 PKU Screening 325 Genetically Modified Foods 325 Genetic Engineering 325 Cloning 326 Gene-Replacement Therapy 326 Chapter 19: Ten Biochemistry Careers 327 Research Assistant 327 Nanotechnologist 328 Quality Control Analyst 328 Clinical Research Associate 328 Technical Writer 329 Biochemical Development Engineer 329 Forensic Scientist 329 Patent Attorney 330 Pharmaceutical Sales Representative 330 Biostatistician 330 Index 331
£19.19
John Wiley and Sons Ltd Statistical Thinking for NonStatisticians in Drug
Book SynopsisSTATISTICAL THINKING FOR NON-STATISTICIANS IN DRUG REGULATION Statistical methods in the pharmaceutical industry are accepted as a key element in the design and analysis of clinical studies. Increasingly, the medical and scientific community are aligning with the regulatory authorities and recognizing that correct statistical methodology is essential as the basis for valid conclusions. In order for those correct and robust methods to be successfully employed there needs to be effective communication across disciplines at all stages of the planning, conducting, analyzing and reporting of clinical studies associated with the development and evaluation of new drugs and devices. Statistical Thinking for Non-Statisticians in Drug Regulation provides a comprehensive in-depth guide to statistical methodology for pharmaceutical industry professionals, including physicians, investigators, medical science liaisons, clinical research scientists, medical writers, regulatory personnel, statistical programmers, senior data managers and those working in pharmacovigilance. The author's years of experience and up-to-date familiarity with pharmaceutical regulations and statistical practice within the wider clinical community make this an essential guide for the those working in and with the industry. The third edition of Statistical Thinking for Non-Statisticians in Drug Regulation includes: A detailed new chapter on Estimands in line with the 2019 Addendum to ICH E9Major new sections on topics including Combining Hierarchical Testing and Alpha Adjustment, Biosimilars, Restricted Mean Survival Time, Composite Endpoints and Cumulative Incidence Functions, Adjusting for Cross-Over in Oncology, Inverse Propensity Score Weighting, and Network Meta-AnalysisUpdated coverage of many existing topics to reflect new and revised guidance from regulatory authorities and author experience Statistical Thinking for Non-Statisticians in Drug Regulation is a valuable guide for pharmaceutical and medical device industry professionals, as well as statisticians joining the pharmaceutical industry and students and teachers of drug development.Table of ContentsPreface to the second edition, xv Preface to the first edition, xvii Abbreviations, xxi 1 Basic ideas in clinical trial design, 1 1.1 Historical perspective, 1 1.2 Control groups, 2 1.3 Placebos and blinding, 3 1.4 Randomisation, 3 1.4.1 Unrestricted randomisation, 4 1.4.2 Block randomisation, 4 1.4.3 Unequal randomisation, 5 1.4.4 Stratified randomisation, 6 1.4.5 Central randomisation, 7 1.4.6 Dynamic allocation and minimisation, 8 1.4.7 Cluster randomisation, 9 1.5 Bias and precision, 9 1.6 Between- and within-patient designs, 11 1.7 Crossover trials, 12 1.8 Signal, noise and evidence, 13 1.8.1 Signal, 13 1.8.2 Noise, 13 1.8.3 Signal-to-noise ratio, 14 1.9 Confirmatory and exploratory trials, 15 1.10 Superiority, equivalence and non-inferiority trials, 16 1.11 Data and endpoint types, 17 1.12 Choice of endpoint, 18 1.12.1 Primary variables, 18 1.12.2 Secondary variables, 19 1.12.3 Surrogate variables, 20 1.12.4 Global assessment variables, 21 1.12.5 Composite variables, 21 1.12.6 Categorisation, 21 2 Sampling and inferential statistics, 23 2.1 Sample and population, 23 2.2 Sample statistics and population parameters, 24 2.2.1 Sample and population distribution, 24 2.2.2 Median and mean, 25 2.2.3 Standard deviation, 25 2.2.4 Notation, 26 2.2.5 Box plots, 27 2.3 The normal distribution, 28 2.4 Sampling and the standard error of the mean, 31 2.5 Standard errors more generally, 34 2.5.1 The standard error for the difference between two means, 34 2.5.2 Standard errors for proportions, 37 2.5.3 The general setting, 37 3 Confidence intervals and p-values, 38 3.1 Confidence intervals for a single mean, 38 3.1.1 The 95 per cent Confidence interval, 38 3.1.2 Changing the confidence coefficient, 40 3.1.3 Changing the multiplying constant, 40 3.1.4 The role of the standard error, 41 3.2 Confidence interval for other parameters, 42 3.2.1 Difference between two means, 42 3.2.2 Confidence interval for proportions, 43 3.2.3 General case, 44 3.2.4 Bootstrap Confidence interval, 45 3.3 Hypothesis testing, 45 3.3.1 Interpreting the p-value, 46 3.3.2 Calculating the p-value, 47 3.3.3 A common process, 50 3.3.4 The language of statistical significance, 53 3.3.5 One-sided and two-sided tests, 54 4 Tests for simple treatment comparisons, 56 4.1 The unpaired t-test, 56 4.2 The paired t-test, 57 4.3 Interpreting the t-tests, 60 4.4 The chi-square test for binary data, 61 4.4.1 Pearson chi-square, 61 4.4.2 The link to a ratio of the signal to the standard error, 64 4.5 Measures of treatment benefit, 64 4.5.1 Odds ratio, 65 4.5.2 Relative risk, 65 4.5.3 Relative risk reduction, 66 4.5.4 Number needed to treat, 66 4.5.5 Confidence intervals, 67 4.5.6 Interpretation, 68 4.6 Fisher’s exact test, 69 4.7 Tests for categorical and ordinal data, 71 4.7.1 Categorical data, 71 4.7.2 Ordered categorical (ordinal) data, 73 4.7.3 Measures of treatment benefit, 74 4.8 Extensions for multiple treatment groups, 75 4.8.1 Between-patient designs and continuous data, 75 4.8.2 Within-patient designs and continuous data, 76 4.8.3 Binary, categorical and ordinal data, 76 4.8.4 Dose-ranging studies, 77 4.8.5 Further discussion, 77 5 Adjusting the analysis, 78 5.1 Objectives for adjusted analysis, 78 5.2 Comparing treatments for continuous data, 78 5.3 Least squares means, 82 5.4 Evaluating the homogeneity of the treatment effect, 83 5.4.1 Treatment-by-factor interactions, 83 5.4.2 Quantitative and qualitative interactions, 85 5.5 Methods for binary, categorical and ordinal data, 86 5.6 Multi-centre trials, 87 5.6.1 Adjusting for centre, 87 5.6.2 Significant treatment-by-centre interactions, 87 5.6.3 Combining centres, 88 6 Regression and analysis of covariance, 89 6.1 Adjusting for baseline factors, 89 6.2 Simple linear regression, 89 6.3 Multiple regression, 91 6.4 Logistic regression, 94 6.5 Analysis of covariance for continuous data, 94 6.5.1 Main effect of treatment, 94 6.5.2 Treatment-by-covariate interactions, 96 6.5.3 A single model, 98 6.5.4 Connection with adjusted analyses, 98 6.5.5 Advantages of ANCOVA, 99 6.5.6 Least squares means, 100 6.6 Binary, categorical and ordinal data, 101 6.7 Regulatory aspects of the use of covariates, 103 6.8 Baseline testing, 105 7 Intention-to-treat and analysis sets, 107 7.1 The principle of intention-to-treat, 107 7.2 The practice of intention-to-treat, 110 7.2.1 Full analysis set, 110 7.2.2 Per-protocol set, 112 7.2.3 Sensitivity, 112 7.3 Missing data, 113 7.3.1 Introduction, 113 7.3.2 Complete cases analysis, 114 7.3.3 Last observation carried forward, 114 7.3.4 Success/failure classification, 114 7.3.5 Worst-case/best-case classification, 115 7.3.6 Sensitivity, 115 7.3.7 Avoidance of missing data, 116 7.3.8 Multiple imputation, 117 7.4 Intention-to-treat and time-to-event data, 118 7.5 General questions and considerations, 120 8 Power and sample size, 123 8.1 Type I and type II errors, 123 8.2 Power, 124 8.3 Calculating sample size, 127 8.4 Impact of changing the parameters, 130 8.4.1 Standard deviation, 130 8.4.2 Event rate in the control group, 130 8.4.3 Clinically relevant difference, 131 8.5 Regulatory aspects, 132 8.5.1 Power >80 per cent, 132 8.5.2 Powering on the per-protocol set, 132 8.5.3 Sample size adjustment, 133 8.6 Reporting the sample size calculation, 134 9 Statistical significance and clinical importance, 136 9.1 Link between p-values and Confidence intervals, 136 9.2 Confidence intervals for clinical importance, 137 9.3 Misinterpretation of the p-value, 139 9.3.1 Conclusions of similarity, 139 9.3.2 The problem with 0.05, 140 9.4 Single pivotal trial and 0.05, 140 10 Multiple testing, 142 10.1 Inflation of the type I error, 142 10.1.1 False positives, 142 10.1.2 A simulated trial, 142 10.2 How does multiplicity arise?, 143 10.3 Regulatory view, 144 10.4 Multiple primary endpoints, 145 10.4.1 Avoiding adjustment, 145 10.4.2 Significance needed on all endpoints, 145 10.4.3 Composite endpoints, 146 10.4.4 Variables ranked according to clinical importance: Hierarchical testing, 146 10.5 Methods for adjustment, 149 10.5.1 Bonferroni correction, 149 10.5.2 Hochberg correction, 150 10.5.3 Interim analyses, 151 10.6 Multiple comparisons, 152 10.7 Repeated evaluation over time, 153 10.8 Subgroup testing, 154 10.9 Other areas for multiplicity, 156 10.9.1 Using different statistical tests, 156 10.9.2 Different analysis sets, 156 10.9.3 Pre-planning, 157 11 Non-parametric and related methods, 158 11.1 Assumptions underlying the t-tests and their extensions, 158 11.2 Homogeneity of variance, 158 11.3 The assumption of normality, 159 11.4 Non-normality and transformations, 161 11.5 Non-parametric tests, 164 11.5.1 The Mann–Whitney U-test, 164 11.5.2 The Wilcoxon signed rank test, 166 11.5.3 General comments, 167 11.6 Advantages and disadvantages of non-parametric methods, 168 11.7 Outliers, 169 12 Equivalence and non-inferiority, 170 12.1 Demonstrating similarity, 170 12.2 Confidence intervals for equivalence, 172 12.3 Confidence intervals for non-inferiority, 173 12.4 A p-value approach, 174 12.5 Assay sensitivity, 176 12.6 Analysis sets, 178 12.7 The choice of Δ, 179 12.7.1 Bioequivalence, 179 12.7.2 Therapeutic equivalence, 180 12.7.3 Non-inferiority, 180 12.7.4 The 10 per cent rule for cure rates, 182 12.7.5 The synthesis method, 183 12.8 Biocreep and constancy, 184 12.9 Sample size calculations, 184 12.10 Switching between non-inferiority and superiority, 186 13 The analysis of survival data, 189 13.1 Time-to-event data and censoring, 189 13.2 Kaplan-Meier curves, 190 13.2.1 Plotting Kaplan-Meier curves, 190 13.2.2 Event rates and relative risk, 192 13.2.3 Median event times, 192 13.3 Treatment comparisons, 193 13.4 The hazard ratio, 196 13.4.1 The hazard rate, 196 13.4.2 Constant hazard ratio, 197 13.4.3 Non-constant hazard ratio, 197 13.4.4 Link to survival curves, 198 13.4.5 Calculating Kaplan-Meier curves, 199 13.5 Adjusted analyses, 199 13.5.1 Stratified methods, 200 13.5.2 Proportional hazards regression, 200 13.5.3 Accelerated failure time model, 201 13.6 Independent censoring, 202 13.7 Sample size calculations, 203 14 Interim analysis and data monitoring committees, 205 14.1 Stopping rules for interim analysis, 205 14.2 Stopping for efficacy and futility, 206 14.2.1 Efficacy, 206 14.2.2 Futility and conditional power, 207 14.2.3 Some practical issues, 208 14.2.4 Analyses following completion of recruitment, 209 14.3 Monitoring safety, 210 14.4 Data monitoring committees, 211 14.4.1 Introduction and responsibilities, 211 14.4.2 Structure and process, 212 14.4.3 Meetings and recommendations, 214 15 Bayesian statistics, 215 15.1 Introduction, 215 15.2 Prior and posterior distributions, 215 15.2.1 Prior beliefs, 215 15.2.2 Prior to posterior, 217 15.2.3 Bayes theorem, 217 15.3 Bayesian inference, 219 15.3.1 Frequentist methods, 219 15.3.2 Posterior probabilities, 219 15.3.3 Credible intervals, 220 15.4 Case study, 221 15.5 History and regulatory acceptance, 222 15.6 Discussion, 224 16 Adaptive designs, 225 16.1 What are adaptive designs?, 225 16.1.1 Advantages and drawbacks, 225 16.1.2 Restricted adaptations, 226 16.1.3 Flexible adaptations, 227 16.2 Minimising bias, 228 16.2.1 Control of type I error, 228 16.2.2 Estimation, 229 16.2.3 Behavioural issues, 230 16.2.4 Exploratory trials, 232 16.3 Unblinded sample size re-estimation, 232 16.3.1 Product of p-values, 232 16.3.2 Weighting the two parts of the trial, 233 16.3.3 Rationale, 234 16.4 Seamless phase II/III studies, 234 16.4.1 Standard framework, 234 16.4.2 Aspects of the p-value calculation, 235 16.4.3 Logistical challenges, 236 16.5 Other types of adaptation, 236 16.5.1 Changing the primary endpoint, 236 16.5.2 Focusing on a sub-population, 237 16.5.3 Dropping the placebo arm in a non-inferiority trial, 237 16.6 Further regulatory considerations, 238 16.6.1 Impact on power, 238 16.6.2 Non-standard experimental settings, 239 17 Observational studies, 241 17.1 Introduction, 241 17.1.1 Non-randomised comparisons, 241 17.1.2 Study types, 241 17.1.3 Sources of bias, 243 17.1.4 An empirical investigation, 244 17.1.5 Selection bias in concurrently controlled studies: An empirical evaluation, 245 17.1.6 Selection bias in historically controlled studies: An empirical evaluation, 246 17.1.7 Some conclusions, 246 17.2 Guidance on design, conduct and analysis, 247 17.2.1 Regulatory guidance, 247 17.2.2 Strengthening the Reporting of Observational Studies in Epidemiology, 248 17.3 Evaluating and adjusting for selection bias, 249 17.3.1 Baseline balance, 249 17.3.2 Adjusting for imbalances using stratification and analysis of covariance, 250 17.3.3 Propensity scores, 250 17.3.4 Different methods for adjustment: An empirical evaluation, 253 17.3.5 Some conclusions, 256 17.4 Case–control studies, 257 17.4.1 Background, 257 17.4.2 Odds ratio and Relative risk, 259 18 Meta-analysis, 261 18.1 Definition, 261 18.2 Objectives, 263 18.3 Statistical methodology, 264 18.3.1 Methods for combination, 264 18.3.2 Confidence intervals, 265 18.3.3 Fixed and random effects, 265 18.3.4 Graphical methods, 266 18.3.5 Detecting heterogeneity, 266 18.3.6 Robustness, 269 18.3.7 Rare events, 269 18.3.8 Individual patient data, 269 18.4 Case study, 270 18.5 Ensuring scientific validity, 271 18.5.1 Planning, 271 18.5.2 Assessing the risk of bias, 273 18.5.3 Publication bias and funnel plots, 273 18.5.4 Preferred Reporting Items for Systematic Reviews and Meta-Analyses, 275 18.6 Further regulatory aspects, 275 19 Methods for the safety analysis and safety monitoring, 277 19.1 Introduction, 277 19.1.1 Methods for safety data, 277 19.1.2 The rule of three, 278 19.2 Routine evaluation in clinical studies, 279 19.2.1 Types of data, 280 19.2.2 Adverse events, 281 19.2.3 Laboratory data, 284 19.2.4 ECG data, 287 19.2.5 Vital signs, 288 19.2.6 Safety summary across trials, 288 19.2.7 Specific safety studies, 289 19.3 Data monitoring committees, 289 19.4 Assessing benefit–risk, 290 19.4.1 Current approaches, 290 19.4.2 Multi-criteria decision analysis, 291 19.4.3 Quality-Adjusted Time without Symptoms or Toxicity, 297 19.5 Pharmacovigilance, 299 19.5.1 Post-approval safety monitoring, 299 19.5.2 Proportional reporting ratios, 300 19.5.3 Bayesian shrinkage, 302 20 Diagnosis, 304 20.1 Introduction, 304 20.2 Measures of diagnostic performance, 304 20.2.1 Sensitivity and specificity, 304 20.2.2 Positive and negative predictive value, 305 20.2.3 False positive and false negative rates, 306 20.2.4 Prevalence, 306 20.2.5 Likelihood ratio, 307 20.2.6 Predictive accuracy, 307 20.2.7 Choosing the correct cut-point, 307 20.3 Receiver operating characteristic curves, 308 20.3.1 Receiver operating characteristic, 308 20.3.2 Comparing ROC curves, 309 20.4 Diagnostic performance using regression models, 310 20.5 Aspects of trial design for diagnostic agents, 312 20.6 Assessing agreement, 313 20.6.1 The kappa statistic, 313 20.6.2 Other applications for kappa, 314 21 The role of statistics and statisticians, 316 21.1 The importance of statistical thinking at the design stage, 316 21.2 Regulatory guidelines, 317 21.3 The statistics process, 321 21.3.1 The statistical methods section of the protocol, 321 21.3.2 The statistical analysis plan, 322 21.3.3 The data validation plan, 322 21.3.4 The blind review, 322 21.3.5 Statistical analysis, 323 21.3.6 Reporting the analysis, 323 21.3.7 Pre-planning, 324 21.3.8 Sensitivity and robustness, 326 21.4 The regulatory submission, 327 21.5 Publications and presentations, 328 References, 331 Index, 339
£60.29
John Wiley and Sons Ltd ABC of Equality Diversity and Inclusion in
Book SynopsisTable of ContentsPreface vii Contributors ix 1 Why Inclusion Matters 1 Shehla Imtiaz-Umer and John Frain 2 The Impact of Bias in Healthcare 11 Habib Naqvi 3 Racism in Healthcare 17 Olivia King and Anton Emmanuel 4 Ethnicity and Disease 27 Mohammad Rizwan Ali, Shehla Imtiaz-Umer, and John Frain 5 Representation in Healthcare Training 37 Diana Akpeki, Zunaira Dara, and John Frain 6 Women in Healthcare 45 Olivia O’Connell and Anna Frain 7 Sexual Orientation and Gender Identity 53 Duncan McGregor 8 Disability Disparities and Ableism in Medicine 61 Lisa I. Iezzoni 9 Migrants and Displaced People 69 James Smith 10 Mental Health 75 Oluwaseun Oluwaranti 11 Privilege, Power and Intersectionality in Healthcare 83 Shehla Imtiaz-Umer 12 Allyship and Being an ‘Active Bystander’ 93 Diana Lautenberger 13 Teaching Equality, Diversity and Inclusion in Healthcare 101 Sylk Sotto-Santiago Index 109
£24.70
John Wiley and Sons Ltd The Advanced Practitioner
Book SynopsisTable of ContentsContributors xviii Preface xxv Acknowledgements xxvii Chapter 1 Advanced Clinical Practice 1 Sadie Diamond-Fox and Vikki-Jo Scott Learning Outcomes 1 Introduction 1 The Concept and History of Advanced-Level Practice 3 Frameworks and Toolkits for Advanced Clinical Practice 3 Ensuring Quality and Governance in Advanced Practice 3 How to Use this Book 5 Conclusion 5 References 7 Further Reading 8 Self-Assessment Questions 8 Glossary 8 Chapter 2 The Advanced Clinical Practice Curriculum 10 Rachael Daw and Ollie Phipps Learning Outcomes 10 Introduction 10 Curriculum Development 12 Understanding the Context of ACP 14 The Clinical Practice Curriculum 14 The Leadership and Management Curriculum 15 The Education Curriculum 15 The Research Curriculum 16 Assessment for ACP 16 Specialist Curriculums, Credentials and Capability Frameworks 18 First Contact Practitioners and Advanced Practitioners – Roadmaps to Practice 19 Supervision and CPD Strategies 19 Conclusion 21 References 22 Further Reading 23 Self-Assessment Questions 24 Glossary 24 Chapter 3 Scope of Practice and Management of Patient Care 25Ollie Phipps Learning Outcomes 25 Introduction 25 The Multi-Professional Framework (MPFFACP) 26 Governance 27 Legal Issues 27 Regulation Statements of Standards and Code of Conducts 28 Nursing and Midwifery Council (NMC) 28 Health and Care Professions Council (HCPC) 28 General Pharmaceutical Council (GPhC) 28 Scope and Capability 28 Defining Scope of Practice 28 Competency vs Capability 29 Knowledge, Skills and Behaviours 29 Competence 29 Multiprofessional Registrations and Scope of Practice 30 Expanding Scope and Scope Creep 30 Responsibility and Accountability 30 Dunning–Kruger Effect 31 Imposter Syndrome 31 Professional Issues 31 Indemnity 33 Indemnity Insurance 33 Negligence 34 Duty of Care 34 Breach of Duty 34 Causation 34 Mental Health Act 1983 and Sections 35 Mental Capacity Act 36 Ethics 37 Autonomy 37 Non-maleficence 38 Beneficence 38 Justice 38 The Right to Life and the Right to Dignity 38 Consent 39 Gillick Competence 39 Confidentiality 39 Development and Regulation 39 Conclusion 40 References 40 Further Reading 42 Self-Assessment Questions 42 Glossary 43 Chapter 4 Principles of Physiology for Advanced Practice 44 Colin Chandler, Alison Wood, and Robin Hyde Learning Outcomes 44 Introduction 45 How the Body Adapts to Different Situations 47 Key Concepts of the Cell 52 Contents vii Control – How the Body Allows us to Achieve Action and Participation in Society 55 Changes to Physiology Through the Life Course 57 Microbiome/Microbiota and Interactions with the Microbiological Environment 61 Conclusion 62 References 63 Further Reading 64 Self-Assessment Questions 64 Glossary 64 Chapter 5 Principles of Pathophysiology 66 Sarah Ashelford and Vanessa Taylor Learning Outcomes 66 Introduction 67 The Main Disease Mechanisms 68 Cancer 69 Aetiology and Pathogenesis of Cancer 70 Clinical Investigations 72 Learning Events 72 Clinical Effects of Cancer 72 Learning Event 72 Cardiovascular Disease and Stroke 73 Investigations 73 Pathogenesis of Atherosclerosis 73 Pharmacological Principles 76 Investigations 76 Diabetes 76 Clinical Presentation 76 Learning Event 77 Aetiology and Pathogenesis of Type 1 Diabetes 77 Aetiology and Pathogenesis of Type 2 Diabetes 78 Acute Complications of Diabetes 79 Respiratory Disease 81 Asthma 81 Aetiology and Pathogenesis of Asthma 81 Pharmacological Principles 83 Learning event 83 Chronic Obstructive Pulmonary Disease 83 Aetiology and Pathogenesis of COPD 83 Conclusion 86 References 86 Further Reading 89 Self-Assessment Questions 89 Glossary 89 Chapter 6 Principles of Pharmacology 90 Ihab Ali and Phil Broadhurst Learning Outcomes 90 Introduction 90 Pharmacotherapy 91 Pharmacokinetics (PK) 91 VIII Contents Pharmacodynamics (pd) 93 Pharmacodynamics: Drug–Receptor Interactions 94 Pharmacodynamics: Drug Concentration 94 Therapeutic Drug Monitoring (TDM) 96 Plasma Protein Binding 98 Drug-induced Adverse Effects 100 Drug Interactions 103 Contraindications 103 Excipients 104 Adherence 104 Conclusion 107 References 107 Further Reading 111 Self-Assessment Questions 111 Glossary 111 Chapter 7 Supplementary and Independent Prescribing 113 Brigitta Fazzini, Esther Clift, and Jill Bentley Learning Outcomes 113 Introduction 113 Education 115 General Pharmacological Principles 115 Prescribing in Paediatrics 115 Prescribing in Mental Health 116 Prescribing in Critical Care 117 Absorption 117 Distribution 117 Metabolism 118 Excretion 119 Assessing Drug Therapy in Critical Illness 119 Prescribing in Older People 120 Medication Reviews 120 Pharmacokinetics 121 Guidelines on Drug Prescription for Older People 122 Antibiotics Stewardship 123 Authorisation of Blood Components and Products 125 Legal Aspects and Governance 125 Patient Consent 126 Clinical Decision Making 126 De-Prescribing 127 Health Promotion 127 Why is This Important to Us as Prescribers? 128 So What Can We Do? 128 Social Prescribing 129 Conclusion 130 References 130 Further Reading 131 Self-Assessment Questions 131 Glossary 131 Chapter 8 Core Procedural Skills 132 Mark Cannan, Kirstin Geer, and Stuart Cox Learning Outcomes 132 Introduction 132 Consent/Assent 133 Clinical Competence for Procedures 134 Preparation: Positioning 135 Core Procedural Skills 137 Airway: Basic Manoeuvres and Adjuncts 137 Airway: Supraglottic Airway Devices 137 Breathing: Intercostal Drain Insertion 137 Preprocedure Set-up and Equipment for ICD Insertion 137 Procedure for ICD Insertion (Seldinger) – Small Bore 139 Procedure for ICD Insertion – Large Bore (Lloyd 2019) 141 Postprocedure Checks 141 Pearls and Pitfalls 141 Circulation: Venepuncture 142 Practitioner Safety 142 Technique 143 Postprocedure Checks 144 Pearls and Pitfalls 144 Circulation: Peripheral Intravenous Cannulation 144 Technique 145 Postprocedure Checks 146 Pearls and Pitfalls 146 Circulation: Arterial Puncture and Cannulation 147 Technique 148 Postprocedure Checks 149 Pearls and Pitfalls 149 Circulation: Central Venous Access Via Central Venous Catheter 149 Technique 150 Pearls and Pitfalls 151 Circulation: Intraosseous Needle Insertion 152 Preprocedure Considerations 152 Pearls and Pitfalls 152 Disability: Lumbar Puncture 153 Technique 154 Pearls and Pitfalls 155 Exposure: Nasogastric Tube Insertion 156 Technique – Awake Patient 156 Technique - Unconscious/Anaesthetised/Intubated Patient 157 Postprocedure Checks 157 Pearls and Pitfalls 157 Learning From Patient Safety Events 158 Conclusion 158 References 159 Further Reading 161 Self-Assessment Questions 161 Glossary 161 Chapter 9 Clinical History Taking and Physical Examination 162 Sadie Diamond-Fox, Rebecca Connolly, Alexandra Gatehouse, and John Wilkinson Learning Outcomes 162 Introduction 162 The Consultation as a Diagnostic Tool 163 Communication 164 The Cone Technique 164 Ideas, Concerns and Expectations (ICE) 165 Triggers to Consultation 165 Consultation Models 165 Calgary-Cambridge Guide to the Medical Interview 167 Patient Perspective of Consultation 168 Kinesics Interviewing 168 Aspects of Obtaining a Medical History 169 History Taking in Special Circumstances: Time-Critical Situations 171 History Taking for Neurodiverse and Non-verbal Populations 172 History Taking for Ethnic Minority Populations 173 History Taking for LGBTQIA+ Populations 173 Clinical Assessment – Aspects of Physical Examination 175 Introduction 175 General Inspection 176 Vital Signs 176 Physical Examination Techniques 177 Hands and Nails 177 Upper Limbs 181 Head and Neck 181 Thorax 185 Abdomen 188 Lower Limbs 190 Closing the Consultation 190 Conclusion 191 References 191 Further Reading 194 Self-Assessment Questions 194 Glossary 194 Chapter 10 Clinical Decision Making and Diagnostic Reasoning 195 Helen Francis-Wenger and Colin Roberts Learning Outcomes 195 Introduction 195 Clinical Reasoning and Clinical Decision Making 197 Recognition 200 Probability 200 Reasoning 200 Watching and Waiting 200 Selective Doubting 201 Iteration and Reiteration 201 Thinking, Growing and Evolving 201 Contents xi Decision-Making Theories 203 Normative, Prescriptive and Descriptive Interactions 203 Descriptive Approach 203 Normative Approach 203 Prescriptive Approach 204 Intuition 204 Hypothetico-Deductive Reasoning 205 Cue Acquisition Stage 205 Hypothesis Generation 205 Cue Interpretation 206 Hypothesis Evaluation 206 The Cognitive Process 206 Biases 207 Assistive Tools and Concepts: Risk Assessments/Probability Scores/Risk Stratification 210 Odds Ratios 210 Numbers Needed to Treat 210 Bayes’ Theorem: Sensitive (Rule Out) and Specific (Rule In) 210 Risk Stratification 211 Conclusion 211 References 211 Further Reading 213 Self-Assessment Questions 213 Glossary 213 Chapter 11 Diagnostic Interpretation 214 Colin Roberts, Christine Eade, and Helen Francis-Wenger Learning Outcomes 214 Introduction 214 Principles to Follow 216 Principles of Ordering and Interpretation 216 Reference Ranges 217 Patient and Clinician Factors to Consider When Interpreting Results: Context 217 The Full Blood Count 217 Haemoglobin 217 A Stepwise Approach 218 White Cells (Leucocytes) 219 Platelets (Thrombocytes) 219 Raised Platelets (>400) 219 Low Platelets (<150) 219 Inflammatory Markers 220 C-Reactive Protein 220 Plasma Viscosity 220 Renal Function 220 Range 220 Creatinine (Cr) 221 Urea (U) 221 Acute Kidney Injury 221 Chronic Kidney Injury 221 Electrolytes: Sodium and Potassium 221 Electrolytes: Calcium and Magnesium 223 Liver Function Tests 225 Alanine Aminotransferase (ALT) 225 Alkaline Phosphatase (ALP) 225 Bilirubin (Br) 225 Patterns of Liver Disease 225 Thyroid Function Tests 226 Hypothyroidism (Underfunctioning) 226 Hyperthyroidism (Overfunctioning) 226 Subclinical Hypothyroidism and Hyperthyroidism 227 Diagnostic Interpretation: Imaging 228 Fundamental Principles 228 The Essentials of Each Imaging Modality are Considered Below 229 Plain Film 229 Ultrasound 232 Lung Ultrasound 232 FAST Scan 233 Echo 233 Computed Tomography 233 Imaging Summary 234 References 235 Further Reading 236 Self-Assessment Questions 236 Glossary 236 Chapter 12 Public Health: Prevention, Promotion and Empowerment 238 Joanna Lavery and Sharon Riverol Learning Outcomes 238 Introduction 238 Accreditation Considerations 240 Clinical Examination 242 Leg assessment 244 Clinical investigation – point-of care (POC) D-dimer testing 244 Diagnosis – Class 1 Cellulitis 245 Pharmacology 245 Follow-up Plan 246 Clinical Examination 248 Results 249 Management 249 Pharmacology 249 Clinical Examination 251 NEWS2 – 0 But Blood Pressure Found to Be Hypotensive 251 Neuro assessment 251 Management 253 Reflections 255 Admission Avoidance 255 Advanced Care Practitioner and Patient Empowerment 255 References 256 Further Reading 261 Self-Assessment Questions 261 Glossary 262 Chapter 13 Managing Complexity 263 Jaclyn Proctor and Sadie Diamond-Fox Learning Outcomes 263 Introductions 263 Medical Complexity 265 Measuring Complexity in a Healthcare Context 266 Situational Complexity 269 Systems Complexity 270 NHS Long Term Plan (2019) 270 Advanced Clinical Practice 272 Conclusion 275 References 276 Further Reading 277 Self-Assessment Questions 277 Glossary 277 Chapter 14 Frailty: Principles of Rehabilitation and Reablement, Palliative Care and Organ Donation 278 Esther Clift and Stevie Park Learning Outcomes 278 Introduction 278 Discharge Planning 279 Intermediate Care 280 Rehabilitation 281 Reablement 282 Pathways 282 Technology 282 Home-based Care 282 Virtual Wards 283 Urgent Community Response 283 Palliative or End-of-Life Care 284 Gold Standard Framework 285 Care Plans 285 Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) 286 Pain and Symptom Control 286 Verifying Death 287 Organ Donation 287 Diagnosing Death by Neurological Criteria (Brainstem Death Testing) 287 Role of the SN-OD and Referral Process 288 Tissue Donation 288 Clinical Frailty 288 Diagnosis Tools for Diagnosis and CGA 288 Exercise 290 Nutrition 290 Social Isolation and Loneliness 291 Conclusion 293 References 293 Further Reading 295 Self-Assessment Questions 295 Chapter 15 Mental Health, Learning Disability and Autism 296 Clare Allabyrne and Jo Delrée Learning Outcomes 296 Introduction 297 Parity of Esteem 297 Diagnostic Overshadowing and Unconscious Bias 297 Mental Health and Ethnicity 298 Communication 298 Therapeutic Communication 298 Fundamental Principles of Therapeutic Communication 298 Specific Issues in Communication Clients with ASD/LD 299 Clinical Investigations 299 Mental Health Screening Tools 299 Holistic Mental Health Assessment 299 Ten-point Guide to Mental State Examination 301 Risk Assessment in Mental Health 301 Assessing Different Groups 302 Assessing Children and Young People 302 Assessing People with Autism 303 Assessing People with Learning Disability 304 A Note on Challenging Behaviour 307 Pharmacological Principles 307 Resources 309 Learning Disability Learning Event 309 Mental Health Learning Event 309 Mental Health UK states 309 Conclusion 310 References 310 Further Reading 313 Self-Assessment Questions 313 Glossary 313 Chapter 16 Education and Learning 315 Joe Wood and Elizabeth Midwinter Learning Outcomes 315 Introduction 316 Principles of Teaching and Learning 316 Understanding How We Learn 316 Recognising Adult Learners 317 Dual Coding Theory 317 Evidence-based Practice 318 Contents xv Self-directed Learning 318 Supporting Others to Develop Knowledge and Skills 318 Feedback 318 Appraisal Processes and Continuing Professional Development 319 Learning From Mistakes: Safety I and Safety II 319 Coaching, Mentoring and Role Modelling 319 Creating an Effective Learning Environment 320 Optimise the Space 320 Physial 320 Virtual 321 Ensure Learner-centredness 321 Get to Know the Learner 322 Plan the Process 322 Create Psychological Safety 323 Promote Continual Improvement Via Reflection 324 Simulation and Technological Advances in Healthcare Education 324 Simulation 324 Teaching Practical Skills – Reflections from Clinical Experience 325 Human Factors 325 Interprofessional Education 326 Types of Simulation 327 The Concept of Fidelity 328 In Situ Simulation 329 Designing Simulated Learning 329 Scenario Writing 330 Practical Considerations 330 Introductions and Orientation 330 Pre-brief 330 Programmed vs On the Fly 331 Debrief 331 Technology-enhanced Learning 333 Conclusion 334 References 334 Further Reading 338 Self-Assessment Questions 338 Glossary 338 Chapter 17 The Advanced Practitioner as Educator 339 Phil Broadhurst Learning Outcomes 339 Introduction 339 Providing Feedback 342 Feeding Back and Feeding Forward 343 The One-Minute Preceptor 345 Conclusion 347 References 347 Further Reading 349 Self-Assessment Questions 350 Glossary 350 Chapter 18 Research Principles 351 Brigitta Fazzini and Roberta Borg Learning Outcomes 351 Why Research Is Important 351 The Research Process 352 Critical Appraisal and the Hierarchy of Evidence 353 Designing a Research Project 354 Every Research Project Starts with a Question 354 Research Methods 355 Scientific Hypothesis 355 Quantitative versus Qualitative Research Methods 356 Quantitative Research Method 357 Qualitative Research Method 359 Healthcare Research Ethics 360 Quality Improvement 362 Conclusion 364 References 364 Further Reading 365 Self-Assessment Questions 366 Glossary 366 Chapter 19 Leading Research in Advanced Practice 367 Leanne Dolman, Joanna De Souza, and Sara Stevenson-Baker Learning Outcomes 368 Introduction 368 Enabling Evidence-Based Practice 369 Using Local Procedures and Protocols – Role Modelling and Ensuring Continuity of Practice 370 Auditing Current Practice 370 Utilising Clinical Audit 371 Setting Standards and Developing New Protocols 371 Setting Intended Outcomes 371 Patient-reported Outcome Measures 372 Reviewing your Protocol (Quality Control) 372 Developing Guidelines at a National/International Level 373 Developing New Evidence for Practice 373 Leading on Quality Improvement 374 Dissemination of Existing and New Knowledge 377 Local Dissemination 377 Presenting at an External Conference 377 Developing a Conference Abstract 378 Developing a Poster 378 Developing an Oral Presentation 378 Writing for Publication 378 Joining a National Forum or Guideline Development Group 378 Developing the Advanced Practitioner as a Clinical Academic 379 Creating A Research Culture at Organisational Level to Improve Person-Centred Healthcare 380 Conclusion 381 References 382 Further Reading 384 Self-Assessment Questions 384 Glossary 384 Chapter 20 Innovations in Practice 386 Vanessa Taylor and Sarah Ashelford Learning Outcomes 386 Introduction 386 Innovation, Practice Development and Service Improvement 388 Innovation and Advanced-level Practice and the Advanced Practitioner Role 392 Advanced-level Practice and Workforce Transformation: An Example of Healthcare Service Innovation 392 Advanced Practitioner as Clinical (Practice Development/ Improvement) and Professional (Service/System Development) Innovator 394 Conclusion 400 References 401 Self-Assessment Questions 403 Glossary 403 Chapter 21 Professional Development and Transition 404 Vikki-Jo Scott and Esther Clift Learning Outcomes 404 Introduction 405 Personal Professional Development 405 Continuing Professional Development and Role Transition 410 Supporting Professional Development Within a Team 412 Contribution to Broader Development of Advanced Practice 415 What Next? 416 Conclusion 416 References 417 Further Reading 417 Self-Assessment Questions 418 Glossary 418 Index 419
£35.14
Wiley-Blackwell A Guide to Genetic Counseling
Book Synopsis
£57.90
McGraw-Hill Education Greenspans Basic and Clinical Endocrinology Tenth
Book SynopsisA full-color guide to the entire field of clinical endocrinology and its scientific underpinnings â updated with the latest breakthroughs and developmentsA Doodyâs Core Title for 2022! Greenspanâs Basic & Clinical Endocrinology delivers a succinct, leading-edge overview of the underlying molecular biology of the endocrine system and the latest perspectives on the diagnosis and treatment of specific diseases and disorders. Featuring an enhanced design that includes hundreds of full-color illustrations and clinical photographs, Greenspanâs is a true must-have during traditional or integrated courses in endocrinology, endocrinology rotation, or exam prep in internal medicine and endocrinology and as reference for disease management.Greenspanâs provides clinically relevant coverage of metabolic bone disease, pancreatic hormones and diabetes mellitus, hypoglycemia, obesity, geriatric endoc
£68.39
John Wiley & Sons Inc Hematology
Book SynopsisHematology Timely morphology resource based on ongoing series of morphology updates published in the American Journal of Hematology since 2008 This is the first book of its kind, written by renowned author Professor Barbara J. Bain, featuring a collection of instructive cases with interesting morphological features initially published in the American Journal of Hematology. This new book aims to bring these interesting and instructive cases to a wider readership. This book features updated cases and a Test Yourself section to aid in reader comprehension and information retention. Cases covered in Hematology: 101 Morphology Updates include: The significance of irregularly contracted cells and hemighosts in sickle cell disease, and striking dyserythropoiesis in sickle cell anemia following an aplastic crisis Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient, and unusual aspects of G6PD Table of ContentsPreface x Note to the reader xi Acknowledgements xii Abbreviations xv 1 Malaria – one swallow makes a summer 1 2 The significance of irregularly contracted cells and hemighosts in sickle cell disease 2 3 Striking dyserythropoiesis in sickle cell anemia following an aplastic crisis 3 4 A normal mean cell volume does not exclude a diagnosis of megaloblastic anemia 4 5 Prominent Howell–Jolly bodies when megaloblastic anemia develops in a hyposplenic patient 6 6 A ghostly presence – G6PD deficiency 7 7 G6PD deficiency in patients identified as female 8 8 The cause of sudden anemia revealed by the blood film 9 9 Choreo-acanthocytosis 10 10 Lead poisoning 12 11 Dysplastic neutrophils in an HIV-positive woman 14 12 Help with HELLP 15 13 Neutrophil dysplasia induced by granulocyte colony-stimulating factor 16 14 COVID-19 and acute kidney injury 17 15 Diagnosis of pyrimidine 5′nucleotidase deficiency suspected from a blood film 19 16 Bone marrow aspirate in Chédiak–Higashi syndrome 20 17 Phytosterolemia 21 18 Pseudo-Chédiak–Higashi inclusions together with Auer rods in acute myeloid leukemia 22 19 Botryoid nuclei resulting from cocaine abuse 23 20 Infantile pyknocytosis 25 21 Splenic rupture in cytomegalovirus infection 27 22 A new diagnosis of monoclonal B-cell lymphocytosis with cytoplasmic inclusions in a patient with COVID-19 29 23 Pseudoplatelets and apoptosis in Burkitt lymphoma 31 24 What is a promonocyte? 32 25 Persistent neonatal jaundice resulting from hereditary pyropoikilocytosis 34 26 Auer rods or McCrae rods? 36 27 Observation of Auer rods in crushed cells in acute promyelocytic leukemia 37 28 Alpha chain inclusions in peripheral blood erythroblasts and erythrocytes 39 29 Dyserythropoiesis in visceral leishmaniasis 41 30 Compound heterozygosity for hemoglobins S and D 42 31 Granular B lymphoblastic leukemia 43 32 Hyposplenism in adult T-cell leukemia/lymphoma 44 33 Voxelotor in sickle cell disease 45 34 The importance of a negative image 48 35 Seeing what isn’t there 49 36 A young woman with sudden onset of a severe coagulation abnormality 50 37 Immature Plasmodium falciparum gametocytes in bone marrow 51 38 Acute myeloid leukemia with myelodysplasia-related changes showing basophilic differentiation 52 39 Thiamine-responsive megaloblastic anemia in an Iraqi girl 53 40 Teardrop poikilocytes in metastatic carcinoma of the breast 54 41 A blood film that could have averted a splenectomy 55 42 Russell bodies and Mott cells 57 43 Dutcher bodies 59 44 Acute myeloid leukemia with inv(16)(p13.1q22) 61 45 Dysplastic macropolycytes in myelodysplasia-related acute myeloid leukemia 63 46 Diagnosis of cystinosis from a bone marrow aspirate 64 47 Emperipolesis in a patient receiving romiplostim 65 48 Mechanical hemolysis: a low mean cell volume does not always represent microcytosis 66 49 Transplant-associated thrombotic microangiopathy 67 50 Neuroblastoma in the bone marrow 69 51 Gray platelet syndrome 70 52 Diagnosis of systemic lupus erythematosus from a bone marrow aspirate 71 53 Diagnosis from a blood film following a dog bite 72 54 Interpreting a postpartum Kleihauer test 73 55 Dengue fever in returning travellers 74 56 Auer rod-like inclusions in multiple myeloma 76 57 Azurophilic granules in myeloma cells 77 58 Plasmodium knowlesi 78 59 The cytological features of NPM1-mutated acute myeloid leukemia 79 60 Irregularly contracted cells in Wilson disease 81 61 Pseudo-Pelger–Huët neutrophil morphology due to sodium valproate toxicity 82 62 The distinctive cytological features of T-cell prolymphocytic leukemia 83 63 Eosinophil morphology in the reactive eosinophilia of Hodgkin lymphoma 86 64 Malaria pigment 87 65 Salmonella colonies in a bone marrow film 88 66 Severe babesiosis due to Babesia divergens acquired in the UK 89 67 Congenital acute megakaryoblastic leukemia 91 68 Basophilic differentiation in transient abnormal myelopoiesis 92 69 Methylene blue-induced Heinz body hemolytic anemia in a premature neonate 93 70 Neutrophil vacuolation in acetominophen-induced acute liver failure 95 71 Howell–Jolly bodies in acute hemolytic anemia 96 72 The distinctive micromegakaryocytes of transformed chronic myeloid leukemia 97 73 Copper deficiency 98 74 Chronic neutrophilic leukemia 99 75 Neutrophilic leukemoid reaction in multiple myeloma 101 76 Persistent polyclonal B lymphocytosis 103 77 Non-hemopoietic cells in the blood and bone marrow 104 78 It’s a black day – metastatic melanoma in the bone marrow 105 79 Dehydrated hereditary stomatocytosis 106 80 Circulating lymphoma cells in intravascular large B-cell lymphoma 107 81 Unusual inclusions in hemoglobin H disease post-splenectomy 108 82 An unexpectedly bizarre blood film in hemoglobin H disease 109 83 Acute myeloid leukemia with a severe coagulopathy and t(8;16)(p11;p13) 111 84 Cold autoimmune hemolytic anemia secondary to atypical pneumonia 113 85 A confusing ‘white cell count’ – circulating micromegakaryocytes in post-thrombocythemia myelofibrosis 114 86 Diagnosis of follicular lymphoma from the peripheral blood 115 87 Transformation of follicular lymphoma 117 88 Cytology of systemic mastocytosis 118 89 Systemic mastocytosis – the importance of looking within bone marrow fragments 119 90 Schistocytosis is not always microangiopathic hemolytic anemia 120 91 Hemoglobin C disease 121 92 Hemoglobin St Mary’s 122 93 Congenital sideroblastic anemia in a female 123 94 A puzzling case of methemoglobinemia 125 95 Hodgkin lymphoma in a bone marrow aspirate 127 96 Giant proerythroblasts in pure red cell aplasia due to parvovirus B19 infection in a patient with rheumatoid arthritis 128 97 A myeloid neoplasm with FIP1L1::PDGFRA presenting as acute myeloid leukemia 129 98 Breast implant-associated anaplastic large cell lymphoma 131 99 Large granular lymphocytosis induced by dasatinib 132 100 The distinctive cytology and disease evolution of blastic plasmacytoid dendritic cell neoplasm 134 101 Platelet phagocytosis as a cause of pseudothrombocytopenia 136 Test yourself 137 Answers to test cases 145 Index 152
£42.74
Wiley-Blackwell The Advanced Practitioner in Pathophysiology and
Book Synopsis
£35.14
John Wiley & Sons Inc ABC of EvidenceBased Healthcare
Book SynopsisA practitioner guide summarizing the aims and achievements of evidence-based healthcare and why it is crucial to modern clinical practice ABC of Evidence-Based Healthcare explains how evidence is developed and formulated into guidance for clinicians. It details how to interpret and apply this evidence to one's own practice and patients, covering areas such as diagnosis and screening, therapy, harm, and prognosis. Some of the key aspects discussed in this book include understanding choice of study design, the roles of quantitative and qualitative research, selecting and using appraisal tools and key statistical concepts. Additionally, the book also covers how to interpret the results of research studies, apply results to the needs of patients, communicate results to colleagues and incorporate them into student training, as well as discussing treatment options, risks, and benefits with patients. As in all ABC books, the text is complemented with practical examples of evidence in practic
£26.99
Wiley-Blackwell Acute Medicine A Practical Guide to the Managemen t of Medical Emergencies 6th Edition
£53.15
John Wiley & Sons Inc Fundamentals of Children and Young Peoples
Book SynopsisThe latest edition of an essential resource for nursing and healthcare students covering the anatomy and physiology of children and young people Fundamentals of Children and Young People's Anatomy and Physiology, 3rd Edition contains the critical knowledge associated with anatomy and physiology required to provide safe and effective care to children and young people. Emphasising the application of evidence-based theory to practice, this comprehensive yet accessible textbook helps nursing and healthcare students understand how children's anatomical and physiological systems influence disease processes and treatment options differently than in adults. This third edition includes an expanded focus on ethnic minority communities and representation of gender and LGBTQI+ issues to ensure a more inclusive understanding of diversity in the population. Readers will also find: A collection of effective pedagogical tools designed to enhance learning, including chapter-specific learning objectives
£38.90
Wiley-Blackwell The Cardiovascular System
Book Synopsis
£20.89
John Wiley & Sons Inc The Nervous System
Book SynopsisA concise, illustrated, and accessible guide to the nervous system Each of the twelve volumes in Peate's Body Systems series is rooted in the belief that a deep and thorough understanding of the human body is essential for providing the highest standard of care. Offering clear, accessible and up-to-date information on different body systems, this series bridges the gap between complex scientific concepts and practical, everyday applications in health and care settings. This series makes for an invaluable resource for those committed to understanding the intricacies of human biology, physiology and the various systems that sustain life. The Nervous System is the perfect companion for students and newly registered practitioners across nursing and allied health fields with an interest in neurological care, providing a comprehensive yet easy-to-digest guide for both academic and clinical application. Equips healthcare students and practitioners with the necessary information to provide saf
£20.89
Wiley-Blackwell The Male Reproductive System
Book Synopsis
£20.89
Wiley-Blackwell The Musculoskeletal System
Book Synopsis
£20.89
John Wiley & Sons Inc The Skin
Book SynopsisA concise, illustrated, and accessible guide to the skin Each of the twelve volumes in Peate's Body Systems series is rooted in the belief that a deep and thorough understanding of the human body is essential for providing the highest standard of care. Offering clear, accessible and up-to-date information on different body systems, this series bridges the gap between complex scientific concepts and practical, everyday applications in health and care settings. This series makes for an invaluable resource for those committed to understanding the intricacies of human biology, physiology and the various systems that sustain life. The Skin is the perfect companion for students and newly registered practitioners across nursing and allied health fields with an interest in dermatological care, providing a comprehensive yet easy-to-digest guide for both academic and clinical application. Equips healthcare students and practitioners with the necessary information to provide safe and competent ca
£20.89
John Wiley & Sons Inc Ear Nose and Throat
Book SynopsisA concise, illustrated, and accessible guide to the ear, nose and throat Each of the twelve volumes in Peate''s Body Systems series is rooted in the belief that a deep and thorough understanding of the human body is essential for providing the highest standard of care. Offering clear, accessible and up-to-date information on different body systems, this series bridges the gap between complex scientific concepts and practical, everyday applications in health and care settings. This series makes for an invaluable resource for those committed to understanding the intricacies of human biology, physiology and the various systems that sustain life. Ear, Nose and Throat is the perfect companion for students and newly registered practitioners across nursing and allied health fields with an interest in Ear, Nose and Throat (ENT) care, providing a comprehensive yet easy-to-digest guide for both academic and clinical application. Equips healthcare students a
£20.89
Wiley-Blackwell Symptoms in the Pharmacy A Guide to the Managemen
Book Synopsis
£47.49
John Wiley and Sons Ltd Essential Medical Genetics Includes Desktop
Book SynopsisAdopted at Cambridge University Essential Medical Genetics provides students, clinicians, counsellors and scientists with the up-to-date information they need regarding the basic principles underlying medical genetics. It also provides guidance on how to apply current knowledge in clinical contexts, covering a wide variety of topics: from genome structure and function to mutations, screening and risk assessment for inherited disorders. This sixth edition has been substantially updated to include, for instance, the latest information on the Human Genome Project as well as several new molecular genetic and chromosome analysis techniques.In full colour throughout, it includes a number of brand new features, including: a large number of self-assessment questions; ''Essentials'' chapter summaries; further reading suggestions; and case study scenarios introducing clinical situations. An invaluable new section gives illustrated practical advice regarding Trade Review“Essential Medical Genetics is the perfect resource for a course on medical genetics, and is now accompanied by a regularly updated website and the FREE enhanced Wiley Desktop Edition (upon purchase of the book) .” (MedReport, 9 October 2012) “I have watched this textbook from its first inception and was disappointed that there was no new edition for so many years. Having waited, the result now is excellent and it has overcome my preference for Emery's Elements as a basic human genetics text.” Emeritus Professor in Clinical Genetics "I find the reference to electronic resources particularly useful, especially for people who approach clinical genetics for the first time and are not familiar with these tools." Dr Sixto García-Miñaúr, Imperial College London, and Hospital Universitario La Paz, Madrid, Spain Reviews of the previous edition "This book is an easy to read, well illustrated introduction to medical genetics. It deals nicely with all the classical aspects of the subject..." Black Bag, Medical Students' Society of Bristol University "...a justifiably popular introductory text." The British Medical JournalTable of ContentsPreface vii Acknowledgements ix How to get the best out of your textbook x Part 1: Basic principles 1 1 Medical genetics in perspective 3 Scientific basis of medical genetics 5 Clinical applications of medical genetics 9 2 The human genome 13 Structure and organisation of the genome 14 Gene identification 14 Th e Human Genome Project 14 3 Nucleic acid structure and function 23 Nucleic acid structure 24 Nucleic acid function 26 Gene regulation 29 DNA replication 31 Mutation types, eff ects and nomenclature 32 4 DNA analysis 41 Basic methods 42 Mutation detection 43 Indirect mutant gene tracking 52 Analysis of DNA length polymorphisms 53 Analysis of single-nucleotide polymorphisms 54 5 Chromosomes 57 Chromosome structure 58 Chromosome analysis 59 Chromosome heteromorphisms 65 Chromosomes in other species 66 Mitochondrial chromosomes 68 Mitosis 69 6 Gametogenesis 73 Meiosis 74 Spermatogenesis 76 Oogenesis 78 Fertilisation 78 X-inactivation and dosage compensation 79 Sex chromosome aberrations 80 Sex determination and differentiation 83 Genomic imprinting (parental imprinting) 83 7 Chromosome aberrations 89 Numerical aberrations 90 Structural aberrations 92 Cytogenetic and molecular methods for the detection of chromosomal aberrations 100 Identification of the chromosomal origin of complex structural rearrangements 107 Other aberrations 111 8 Typical Mendelian inheritance 117 Introduction to autosomal single-gene inheritance 118 Autosomal dominant inheritance 118 Autosomal recessive inheritance 120 Introduction to sex-linked inheritance 123 X-linked recessive inheritance 125 X-linked dominant inheritance 127 Y-linked inheritance (holandric inheritance) 128 9 Atypical Mendelian inheritance 131 Genetic anticipation 132 Pseudoautosomal inheritance 134 Autosomal dominant inheritance with sex limitation 134 Pseudodominant inheritance 134 X-linked dominant inheritance with male lethality 135 Mosaicism 135 Modifi er genes and digenic inheritance 135 Uniparental disomy 136 Imprinting disorders 136 10 Non-Mendelian inheritance 141 Multifactorial disorders 142 Somatic cell genetic disorders 147 Mitochondrial disorders 147 11 Medical genetics in populations 151 Selection for single-gene disorders 152 Founder effect and genetic drift for single-gene disorders 153 Altered mutation rate for single-gene disorders 154 Linkage analysis and the International Hapmap Project 154 Human population evolution and migration 155 Part 2: Clinical applications 161 12 Genetic assessment, genetic counselling and reproductive options 163 Communication of advice 164 Special points in counselling 168 Prenatal diagnosis 170 Amniocentesis 170 Chorionic villus sampling 174 Cordocentesis, fetal skin biopsy and fetal liver biopsy 175 Ultrasonography 175 Fetal cells in the maternal circulation 175 Free fetal DNA and RNA detection 175 Preimplantation genetic diagnosis 176 13 Family history of cancer 179 General principles 180 Tumour suppressor genes 181 Genes involved in DNA repair mechanisms 187 Oncogenes 187 Other cancer-related genes 189 Genetic counselling aspects of cancer 189 Common familial cancer predisposition syndromes 189 14 Family history of common adult-onset disorder 199 General principles 200 Diabetes mellitus: common and monogenic forms 200 Dementia: Alzheimer disease, Huntington disease, prion diseases and other causes 202 15 Strong family history – typical Mendelian disease 209 Cystic fibrosis 210 Duchenne and Becker muscular dystrophies 212 Neurofi bromatosis type 1 214 16 Strong family history – other inheritance mechanisms 219 Myotonic dystrophy 220 Fragile X syndrome 221 Mitochondrial disorder 222 Imprinting-related disorder 223 Chromosomal translocation 224 17 Screening for disease and for carriers 229 Prenatal screening 230 Neonatal screening 233 Carrier detection in the adult population 234 Presymptomatic screening of adults 237 18 Family history of one or more congenital malformations 241 Aetiology 242 Chromosomal disorders 243 Neural tube defects 247 Teratogenic eff ects 250 Multiple malformation syndromes 253 Part 3: Electronic databases – a user's guide 265 19 Electronic databases – a user's guide 267 Finding information regarding specifi c conditions and names of associated genes 268 Laboratories undertaking genetic testing 270 Patient information and support groups 270 Gene- and protein-specifi c sequence, structure, function and expression information 272 Nucleotide sequences and human mutations 281 Automatic primer design tools 281 Displaying map data for genes and markers 287 Online missense mutation analysis tools 288 Computer-aided syndrome diagnosis 293 Professional genetics societies 297 Th e Human Genome Project: ethics and education 297 Self-assessment – answers 305 Appendix 1: Odds, probabilities and applications of Bayes’ theorem 312 Appendix 2: Calculation of the coeffi cients of relationship and inbreeding 314 Appendix 3: Population genetics of single-gene disorders 315 Appendix 4: Legal aspects 317 Glossary 318 Index 324
£42.70
Elsevier - Health Sciences Division Dorlands Illustrated Medical Dictionary
Book SynopsisTrade Review"Dorland's is one of the most comprehensive medical dictionaries on the market." -Iris Kovar-Gough, MA, MLIS(Michigan State University Libraries) Doodys Review Service
£40.84
Kaplan Publishing Clinical Management Complete 2-Book Subject
Book SynopsisThese are the same books used in Kaplan Medical’s courses and trusted by thousands of medical students each year to succeed on the exam. The books are entirely made up of case-based scenarios, with Differential Diagnoses, Testing, Discussion, and Management. Volume 1 cases address Internal Medicine, Psychiatry, and Ethics. Volume 2 cases address Pediatrics, Obstetrics/Gynecology, Surgery, Epidemiology/Biostatistics, Patient Safety. Up-to-date. Updated biannually by Kaplan’s all-star faculty. Complete. Includes basic science correlates likely to be tested on the exam, patient management from the experts, patient safety, and population health.Learner-efficient. Case-based content (250+ in-depth cases) organised in outline format presents material for both the Foundations of Independent Practice (FIP) and Advanced Clinical Medicine (ACM) components of the examTrusted. Used by thousands of students each year to succeed on the USMLE Step 3 and COMLEX-USA Level 3.Clinical Management Review Complete 2-Book Set 2023-2024 assumes mastery of both the preclinical (discipline-based) and clinical sciences, both of which are covered in Kaplan's other bundles.
£93.75
American Society for Microbiology Manual of Clinical Microbiology, 4 Volume Set
Book Synopsis
£289.80
World Scientific Europe Ltd Osces Made Easy A Guide For Medical Students And
Book SynopsisOSCEs Made Easy is tailored for undergraduate medical students and postgraduate medical trainees. It is a practical guide on how to prepare rigorously and systematically for OSCEs, and to secure yourself a high-scoring result. A compilation of personal revision notes combined with stories about what works well, the objective of this book is to provide every final-year medical student with the information we wish we had known going into OSCE revision. For what it is worth, all of us contributing to this book passed the OSCEs with distinctions!This book is not just an exam crammer. It is also an excellent resource for the first years on the clinical wards challenged by a complex patient on the cardiology ward, or for those who forgot how to properly examine a patient with a neurological complaint in the emergency room. The reader of this book will be provided with the resources to take a focused history, perform a proper examination, and prescribe and do basic procedures.
£52.25
World Scientific Europe Ltd Revision Guide To Core Clinical Medicine The
Book SynopsisAce your medical exams with The Revision Guide to Core Clinical Medicine!Unlock your medical potential with The Revision Guide to Core Clinical Medicine - the ultimate companion for every aspiring doctor, written by graduates from the University of Cambridge. This comprehensive resource takes students through eight core specialities, from pharmacology and investigations to the diagnosis and management of conditions, helping to save time and reduce levels of stress for medical students.Truly understand and excel in the essential knowledge needed to succeed.Instead of needing multiple books for each subject area - such as different specialities, pharmacology and investigations - this exhaustive revision guide covers the key information in one convenient resource. Packed with vital information across eight core specialities, this unique book will help you ace your clinical exams.All the must-know information in one comprehensive and easy-to-understand book.
£52.25
M&K Update Ltd Self-Assessment in Paediatric Musculoskeletal
Book Synopsis
£37.05
£999.99
Springer Nature Switzerland AG The Biopsychosocial Model of Health and Disease:
Book SynopsisThis open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.Table of ContentsPart I. The biopsychosocial model: a diagnostic assessment.- Ch. 1. Much invoked – but deeply flawed?.- Ch.2. Locating the scientific and clinical content.- Ch. 3 The core theory problem: biopsychosocial causal interactions.- Ch. 4 The first step: updating the biomedical model.- Part II. Core non-reductionist concepts in biology and biomedicine.- Ch.5 Biology.- Ch.6 Physicalism.- Part III. Biology opens up to the BioPsychoSocial.- Ch.7 The Biomedical Model opens up to the Biopsychosocial.- Ch.8 The Psychological as Agency.- Ch.9 Conditions of Agency.- Ch.10 The socio-political : who gets to control what?.- Ch.11 Biopsychosocial systems.- Part IV. Biopsychosocial conditions of health and disease.- Chapter 12. Conditions of biological, psychological and social life.- Chapter 13. Biopsychosocial conceptualisation of health conditions.- Chapter 14. Locating causes in biopsychosocial systems.- Chapter 15. Compare and contrast physical and mental health conditions.- Ch.16 Locating the Biopsychosocial Model.
£19.00
Springer Nature Switzerland AG Absolute Addiction Psychiatry Review: An
Book SynopsisThis book serves as a tool for general psychiatrists, medical students, residents, and fellows looking for a clinically relevant and high-yield overview of addiction psychiatry in preparation for their board exams – or for everyday clinical practice. Written by expert educators in addiction psychiatry, the text is organized by substances misused and populations affected. This book serves as both a primary learning tool for those new to the field, as well as a reference for those working in addiction treatment. Each chapter begins with summaries of high yield clinical pearls, followed by general information including treatment, and then ends with accompanying board-style review questions. The scope includes understanding substances of misuse and substance use disorders (SUDs), how to evaluate, diagnose, and monitor SUDs, how to treat SUDs both pharmacologically and behaviorally, and critical information for specific populations of patients. Absolute Addiction Psychiatry for Clinical Practice and Review is an excellent resource for all medical students, residents, fellows, and professionals taking certification exams in addiction, including those in psychiatry, addiction medicine, emergency medicine, internal medicine, pain medicine, and others. The chapter "Laboratory Testing for Substance Use Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of ContentsPart 1- Diagnosis, Treatment Modalities and Settings, Recovery 1. Evaluation and diagnosis of Substance Use Disorder 2. Addiction Treatment Settings and Levels of Care 3. Recovery from Addiction and Treatment Moniotring 4. Non-pharmacologic Treatment across Substances 5. Special Focus: Issues in the US Opioid Epidemic Part 2- Substances and their Treatments 6. Nicotine 7. Alcohol 8. Benzodiazepines 9. Cannabis 10. Opioids 11. Stimulants- Cocaine and Amphetamines 12. Steroids, Dissociatives, Club Drugs, Inhalants, Hallucinogens Part 3- Populations 13. Adolescents and Students 14. Women and Pregnancy 15. Lesbian, Gay, Bisexual, Trans (LGBT) 16. Underserved Populations 17. Older Adults 18. Co-occurring Medical Disorders 19. Co-occurring Psychiatric Disorders
£80.99
Springer International Publishing AG The Bethesda System for Reporting Thyroid
Book SynopsisThe previous edition of The Bethesda System for Reporting Thyroid Cytopathology provided important updates and advances in the practice of thyroid cytopathology. It was inspired by new developments in the field of thyroid cytopathology since the publication of the first edition in 2010. These included revised clinical guidelines for the management of patients with thyroid nodules, the introduction of molecular testing as an adjunct to cytopathologic examination, and the reclassification of the non-invasive follicular variant of papillary thyroid carcinoma as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). This new third edition provides updates to the current reporting terminology and diagnostic criteria, including new information on ancillary molecular testing, as well as imaging findings and clinical management. This book provides a more unified approach to diagnosing and reporting thyroid FNA interpretations. It simplifies the reporting structure by settling on just one name for each of the six categories and aligning terminology with the most recent classification of thyroid tumors by the World Health Organization. Written by experts in the field, The Bethesda System for Reporting Thyroid Cytopathology, Third Edition aims to inspire advances in thyroid cytopathologic diagnosis and the betterment of patients with thyroid nodular disease. It serves as a reference guide not just for pathologists, but also endocrinologists, surgeons, and radiologists. Table of Contents
£53.99
Springer International Publishing AG Practical Point-of-Care Medical Ultrasound
a huge range and FREE tracked UK delivery on ALL orders.
£67.49
Springer International Publishing AG Handbook of Clinical Teaching
a huge range and FREE tracked UK delivery on ALL orders.
£62.99
Jaypee Brothers Medical Publishers Acute Rheumatic Fever and Chronic Rheumatic Heart
Book SynopsisTable of Contents1. Lessons Learnt from History of Rheumatic Heart Diseases 2. Rheumatic Fever and Rheumatic Heart Disease: A 4-century Review with Special Reference to India 3. Epidemiology of Group a Streptococcal Infections, Rheumatic Fever, and Rheumatic Heart Disease 4. Can We Change the Epidemiological Trend of Rheumatic Heart Disease in India? 5. Etiopathogenesis and Management of Streptococcal Infection 6. Laboratory Diagnosis of Group A B-hemolytic Streptococcal Infections 7. Etiopathogenesis and Pathology of Carditis in Rheumatic Fever 8. Pathology of Chronic Rheumatic Heart Disease 9. Etiopathogenesis, Clinical Manifestations, and Diagnosis of Acute Rheumatic Fever 10. Cardiac Complications of Acute Rheumatic Fever 11. Role of Echocardiography in Diagnosis of Carditis in Acute Rheumatic Fever 12. Clinical Profile of Rheumatic Heart Disease 13. Role of Echocardiography in Rheumatic Heart Disease 14. Consensus and Controversies in the Management of Acute Rheumatic Fever: Introducing Armor to Prevent and Protect 15. Medical Management of Rheumatic Heart Disease and Management during Pregnancy, Noncardiac Surgery, and Infective Endocarditis 16. Echocardiographic Screening for Rheumatic Heart Disease 17. Prevention and Vaccine for Rheumatic Fever: How Far are We? 18. Natural History of Rheumatic Fever and Rheumatic Heart Disease 19. Nonsurgical Management of Rheumatic Heart Disease 20. Transcatheter Treatment of Rheumatic Mitral Stenosis in Pediatric Age Group 21. Surgical Management of Rheumatic Heart Disease 22. Rheumatic Fever, Rheumatic Heart Disease Registry, and Control Program
£78.85
Jaypee Brothers Medical Publishers Luthra's ECHO Made Easy
Book SynopsisTable of Contents1. What is an Echo? 2. Conventional Echo 3. Color Doppler Echo 4. Echo Windows 5. Normal Views and Values 6. Newer Modalities in Echo 7. Ventricular Dysfunction 8. Cardiomyopathies 9. Coronary Artery Disease 10. Systemic Hypertension 11. Pulmonary Hypertension 12. Diseases of Aorta 13. Congenital Diseases 14. Valvular Diseases 15. Pericardial Diseases 16. Endocardial Diseases 17. Intracardiac Masses 18. Thromboembolic Diseases 19. Systemic Diseases
£25.21
Jaypee Brothers Medical Publishers A Practical Guidebook in Femoral Neck Fixation
Book SynopsisThe femur, or thigh bone, is the only bone in the thigh and is the longest bone in the body. It acts as the site of origin and attachment for many muscles and ligaments, and the head forms a ball and socket joint with the hip.The femoral neck connects the femoral shaft with the femoral head. Femoral neck fractures are a type of intracapsular hip fracture the junctional location makes the neck prone to fracture.TheFemoral Neck System(FNS) addresses clinical challenges associated with thefixationoffemoral neckfractures.Authored by a team of highly experienced trauma surgeons and orthopaedic specialists, this book provides a comprehensive overview of the FNS, detailing its design, biomechanical principles, clinical applications, and rehabilitation protocols.The book begins with a detailed examination of femoral neck fractures, including definitions, classifications, epidemiology, and incidence rates, as well as comparative analysis of various fixation methods.The next chapter covers design and components of implants, including screws, plates, and locking mechanisms.The following sections provide step-by-step surgical procedures for femoral neck fracture fixation, explaining positioning, intraoperative considerations, tips for optimal implant placement, and postoperative care and rehabilitation.The book concludes with discussion on common complications and their management, clinical outcomes and studies, and future perspectives and innovations.Compiling the latest data, research and expert opinions, chapters feature anecdotal notes for the fixation system, pearls, charts, figures, and diagrams, to provide an invaluable resource for specialists involved in the management of femoral neck fractures.
£15.00
Jaypee Brothers Medical Publishers Step by Step Chemical Peels
Book SynopsisThe third edition has been fully revised to provide the most recent advances in chemical peeling. Topics new to this edition include lip peels, periocular peels, nail peels, hand peels, and body peels. There is also discussion on combining peels with other procedures such as lasers and microneedling, to optimise results.
£31.35
Jaypee Brothers Medical Publishers OSCE in Critical Care Medicine - 1
Book SynopsisThe OSCEs have become a part of most examinations in Critical Care Medicine. This book will be of great help to the examinees. The contents have been divided into two sections one is Questions and the second is Answers. It contains chapters on Respiratory Medicine, Neurology, Nephrology, Microbiology and Infection Control, Hemodynamics, Drugs, Biochemistry, Miscellaneous, and Case Scenarios. Contains nearly 330 questions with model answers. Questions range from the old tests, new techniques and devices, and results of laboratory and other investigations. Also covers questions on all organ systems and different ways these systems may be affected by the disease. The answers are structured from examination point-of-view. These will help the examinees in developing the skills to face the objective structured clinical examinations (OSCEs) in their examination. Table of ContentsQUESTIONS 1. Respiratory Medicine 2. Neurology 3. Nephrology 4. Microbiology and Infection Control 5. Hemodynamics 6. Drugs 7. Biochemistry 8. Miscellaneous 9. Case Scenarios ANSWERS 1. Respiratory Medicine 2. Neurology 3. Nephrology 4. Microbiology and Infection Control 5. Hemodynamics 6. Drugs 7. Biochemistry 8. Miscellaneous 9. Case Scenarios
£24.70
TFM Publishing Ltd FIBROMYALGIA
Book SynopsisIn an interesting survey amongst doctors, fibromyalgia was considered the least prestigious disease. Although this survey was done in a Scandinavian country and was done more than 13 years ago, the grim situation is still the same today all over the world. Patients suffering with fibromyalgia feel that they are not believed and they are not listened to. Despite knowledge being gathered on this disease for a few centuries, and having definite diagnostic criteria and management pathways, the healthcare system still fails many patients who are left without a diagnosis or treatment plan. Fibromyalgia is a disease that causes widespread pain in many areas of the body and has significant accompanying symptoms like fatigue, waking unrefreshed and cognitive symptoms. Fibromyalgia affects patients as a whole including their cognitive performance, physical skills, psychological status, ability to work and social life. It can present as a part of the spectrum of functional pain syndromes, often accompanied by other systemic conditions such as irritable bowel syndrome, headaches and chronic fatigue. It is estimated that 1 in 20 can suffer with this debilitating condition. This textbook will cover the condition in great detail and is written in an easy-to-understand style. Doctors, nurses, medical students, physiotherapists, occupational therapists, psychologists, and other healthcare professionals will find this book informative. Patients who suffer from fibromyalgia will also find it useful to understand their medical condition; the book will help to direct them to specific treatment strategies, explaining the benefit and risk in detail. As this is a common chronic pain presentation, it will be of immense use to candidates preparing for examinations conducted by the Royal College of Anaesthetists, UK (FRCA), Faculty of Pain Medicine, UK (FFPMRCA), American Board of Anesthesiology (AB), College of Anaesthesiologists of Ireland (FCAI), European Society of Anaesthesiology and Intensive Care (EDAIC), Australian and New Zealand College of Anaesthetists (FANZA), World Institute of Pain (FIPP/CIPS), Canadian Board exams, National Board of Examinations of India (Dip NB) and other competitive exams across the globe. The author is a senior consultant in pain medicine practising in the United Kingdom and is consulted by thousands of chronic pain patients every year. He has won many educational awards including a national innovative award in pain medicine. One of his innovations is published in the list of examples of excellence by the Faculty of Pain Medicine, London. He has lectured at many international, national and regional meetings, and is a regular invited expert lecturer in public groups and fibromyalgia patient support groups. He has also published many articles and textbooks on pain medicine.
£22.50
Elsevier Health Sciences Braunwalds Heart Disease Single Volume
a huge range and FREE tracked UK delivery on ALL orders.
£211.49
Wiley-Blackwell Lecture Notes Geriatric Medicine and Elderly Care
Book Synopsis
£37.00
Wiley-Blackwell Bone Marrow Pathology 6th Edition
Book Synopsis
£139.45
Johns Hopkins University Press Parkinsons Disease
Book SynopsisRecent innovations, including deep brain stimulation and new medications, have significantly improved the lives of people who have Parkinson's disease. Nevertheless, patients and families continue to face many challenges. This book is suitable for reliable advice about medical, emotional, and physical issues.Trade ReviewThe best comprehensive guide on Parkinson's disease I have ever read. If I were suggesting a book for my primary care physician to read on Parkinson's disease, this would be the one. APDA Young Parkinson's Newsletter Patients and their loved ones will find this practical guide the perfect complement to a physician's care. Publishers WeeklyTable of ContentsPrefacePart I: Introduction1. What Is Parkinson's Disease?2. Who Gets Parkinson's Disease?Part II: Signs and Symptoms of Parkinson's Disease3. Early Symptoms4. Moderate Parkinson's Disease5. Advanced Parkinson's Disease6. Behavioral Changes and Psychiatric Symptoms7. Young-Onset Parkinson's DiseasePart III: Diagnosing Parkinson's Disease8. How a Diagnosis Is Made9. Types of Parkinsonism10. Diagnosing Other Neurologic ProblemsPart IV: Treatment of Parkinson's Disease11. How the Brain Works and How TreatmentWorks12. Choosing the Correct Medications13. Drug Therapies14. Exercise and Rehabilitation Therapy15. Diet and Complementary/AlternativeTherapies16. Surgical TreatmentsPart V: Other Issues17. Illness, Hospitalization, and Parkinson's Disease18. Parkinson's Disease Research19. Questions and AnswersResourcesIndex
£19.95
