Clinical and internal medicine Books

Book SynopsisMore than 85% of people with diabetes receive their diabetes care in the primary care setting. With the busy primary care practitioner in mind, Everyday Diabetes in Primary Care: A Case-Based Approach offers dozens of diabetes cases in an easy-to-digest format—each representing a common clinical question that clinicians face in this common and complex area. For every case, fellowship-trained diabetologist Dr. Jay Shubrook shares his considerable expertise, providing authoritative, real-world guidance for your day-to-day management of patients with diabetes. Uses commonly seen cases to introduce each problem and provide a framework for building a diagnostic or therapeutic plan Explores such key topics as clinical presentation, initial evaluation, engaging the patient in therapeutic lifestyle change, navigating pharmacotherapy, getting ahead of diabetes, and treating across the spectrum of disease Allows clinicians to access specific, relevant topics in a quick-reference, highly focused format Provides high-yield information and guidance from an expert in this complex field Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. Trade Review "A Case-Based Approach is an insightful book on diabetes for the primary care clinician. The clarity of language, thought and organization of the book stands out among academic texts. It is written with the learner in mind. Whether you are a student, resident, or an attending physician there is something in this book for you and you will learn a lot about the care of patients with diabetes. And….it is an enjoyable read!" - Neil  Skolnik,  M.D., Professor  of Family and Community Medicine, Sidney Kimmel  Medical College, Thomas Jefferson University, Associate Director, Family Medicine Residency Program, Jefferson Health - Abington "As a dedicated pediatrician and medical educator, I am always on the lookout for resources that can enhance my understanding and approach to patient care. Everyday Diabetes in Primary Care: A Case-Based Approach has truly exceeded my expectations. The case-based approach is brilliant, as it provides real-world scenarios that resonate with primary care clinicians like myself. Each case is meticulously crafted to encompass the complexities and challenges that we often encounter in our day-to-day interactions with patients. One of the standout features of the book is its practicality. Dr. Shubrook doesn't just present cases; he guides us through the diagnostic and management process, offering insightful strategies and evidence-based recommendations. I particularly appreciate how he addresses the nuances of diabetes care, taking into account individual patient preferences, comorbidities, and cultural considerations. Everyday Diabetes in Primary Care also excels in its readability. Dr. Shubrook has a remarkable ability to explain complex medical concepts in a clear and concise manner, making the book accessible to a wide range of healthcare professionals. Whether you're a seasoned physician or a student in training, you'll find the content engaging and easy to grasp. The book doesn't just stop at clinical cases. It delves into the psychosocial aspects of diabetes, shedding light on the emotional challenges that patients face. This compassionate approach resonates deeply with me. Furthermore, the book stays up-to-date with the latest developments in diabetes management, ensuring that readers receive the most current information. In conclusion, Everyday Diabetes in Primary Care: A Case-Based Approach by Dr. Jay Shubrook is exceptional. Its practicality, readability, and comprehensive coverage make it an invaluable resource for any healthcare professional looking to enhance their diabetes management skills. I wholeheartedly recommend this book to my colleagues and students." Tami Hendriksz, DO, FACOP, FAAP, Dean & Chief Academic Officer, College of Osteopathic Medicine, Touro University California

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Book SynopsisConcise, portable, and user-friendly, The Washington Manual® Pulmonary Medicine Subspecialty Consult, Third Edition, provides quick access to essential information on the diagnosis and management of a variety of acute and chronic lung diseases. Edited by Drs. Adam Anderson, Colleen McEvoy, Mary Clare McGregor, and Shail Mehta, this bestselling manual offers state-of-the-art guidance on the physical exam, diagnosis, management, and treatment follow-up for various pulmonary disorders, including COPD, cystic fibrosis, pulmonary infections, and much more. Ideal for pulmonary medicine fellows, internal medicine residents, advanced practice providers, and medical students rotating on pulmonary subspecialty services, the manual is also useful as a first-line resource for internists and other primary care providers. Enables on-the-spot bedside patient diagnosis and management with quick, efficient answers to your fundamental questions about diagnosing and treating numerous pulmonary diseases and disorders Thoroughly revised to include new content on COVID-19, interstitial lung disease, pulmonary hypertension, asthma, tobacco abuse and vaping lung injury, mycobacterial disease, and pulmonary complications related to anti-neoplastic agents Uses a consistent format throughout and presents symptoms, signs, and problems in quick-reference, bulleted lists for easy, everyday reference Written by specialty fellows and faculty in the Department of Medicine at Washington University School of Medicine in St. Louis The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University.

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Book SynopsisThis brief, clinically-focused volume is informed by Lawrence I. Golbe’s three decades of research and tertiary clinical care in progressive supranuclear palsy, a complex disorder with rapidly changing diagnostic and therapeutic approaches. It is an ideal source for the general neurologist seeking a refresher and the primary care provider, neurological nurse, or physical, occupational or speech therapist who must address their patients’ specialized needs. A Clinician’s Guide to Progressive Supranuclear Palsy emphasizes early diagnostic signs, medication options, non-pharmacologic management and palliative care. It offers a quick overview of the complications of PSP most likely to prompt an ER visit; a widening spectrum of PSP variants; and ample description of the genetics, epidemiology, natural history, pathology, molecular biology and neurochemistry of PSP. The PSP Rating Scale used in the book is a convenient tool for clinicians in routine practice and the leading PSP clinical measure world-wide. Golbe provides a practical and useful guidebook to help all clinicians learn and battle this complex disorder. Trade Review"Lawrence I. Golbe, a distinguished expert on Progressive Supranuclear Palsy, presents a timely guide for practicing clinicians. An essential reading and reliable roadmap in dynamic days." -- Günter U. Höglinger, MD“Professor Golbe’s guide is the story, well told and easily read, of a passionate clinician’s long journey towards understanding of this rare disease. It is comprehensive, a literary landmark of 2018, and it gives optimism about eventual cure." -- John C. Steele * M.D. *Table of ContentsPreface 1. History 2. Descriptive Epidemiology 3. Analytical Epidemiology 4. Clinical Rating Scales for PSP 5. The Clinical Spectrum of PSP 6. Differential Diagnosis 7. Diagnostic Criteria for PSP 8. Diagnosis of Early PSP 9. Cognitive and Behavioral Features 10. Eye movement 11. Dysarthria 12. Dysphagia 13. Physical and Occupational Therapy 14. Palliative care 15. Sleep 16. Imaging 17. Genetics 18. Drug Treatment for General and Motor Features 19. Emergency Management of PSP 20. Organization and Infrastructure of PSP Care 21. What’s Coming? About the Author

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Book SynopsisThis open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model’s scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model’s scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.Table of ContentsPart I. The biopsychosocial model: a diagnostic assessment.- Ch. 1. Much invoked – but deeply flawed?.- Ch.2. Locating the scientific and clinical content.- Ch. 3 The core theory problem: biopsychosocial causal interactions.- Ch. 4 The first step: updating the biomedical model.- Part II. Core non-reductionist concepts in biology and biomedicine.- Ch.5 Biology.- Ch.6 Physicalism.- Part III. Biology opens up to the BioPsychoSocial.- Ch.7 The Biomedical Model opens up to the Biopsychosocial.- Ch.8 The Psychological as Agency.- Ch.9 Conditions of Agency.- Ch.10 The socio-political : who gets to control what?.- Ch.11 Biopsychosocial systems.- Part IV. Biopsychosocial conditions of health and disease.- Chapter 12. Conditions of biological, psychological and social life.- Chapter 13. Biopsychosocial conceptualisation of health conditions.- Chapter 14. Locating causes in biopsychosocial systems.- Chapter 15. Compare and contrast physical and mental health conditions.- Ch.16 Locating the Biopsychosocial Model.

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Book SynopsisThe second edition of this volume provides insight and practical illustrations on how modern statistical concepts and regression methods can be applied in medical prediction problems, including diagnostic and prognostic outcomes. Many advances have been made in statistical approaches towards outcome prediction, but a sensible strategy is needed for model development, validation, and updating, such that prediction models can better support medical practice.There is an increasing need for personalized evidence-based medicine that uses an individualized approach to medical decision-making. In this Big Data era, there is expanded access to large volumes of routinely collected data and an increased number of applications for prediction models, such as targeted early detection of disease and individualized approaches to diagnostic testing and treatment. Clinical Prediction Models presents a practical checklist that needs to be considered for development of a valid prediction model. Steps include preliminary considerations such as dealing with missing values; coding of predictors; selection of main effects and interactions for a multivariable model; estimation of model parameters with shrinkage methods and incorporation of external data; evaluation of performance and usefulness; internal validation; and presentation formatting. The text also addresses common issues that make prediction models suboptimal, such as small sample sizes, exaggerated claims, and poor generalizability. The text is primarily intended for clinical epidemiologists and biostatisticians. Including many case studies and publicly available R code and data sets, the book is also appropriate as a textbook for a graduate course on predictive modeling in diagnosis and prognosis. While practical in nature, the book also provides a philosophical perspective on data analysis in medicine that goes beyond predictive modeling. Updates to this new and expanded edition include:• A discussion of Big Data and its implications for the design of prediction models• Machine learning issues• More simulations with missing ‘y’ values• Extended discussion on between-cohort heterogeneity• Description of ShinyApp• Updated LASSO illustration• New case studies Trade ReviewTable of ContentsPreface viiAcknowledgements xiChapter 1 Introduction 11.1 Diagnosis, prognosis and therapy choice in medicine 11.1.1 Predictions for personalized evidence-based medicine 11.2 Statistical modeling for prediction 51.2.1 Model assumptions 51.2.2 Reliability of predictions: aleatory and epistemic uncertainty 61.2.3 Sample size 61.3 Structure of the book 81.3.1 Part I: Prediction models in medicine 81.3.2 Part II: Developing internally valid prediction models 81.3.3 Part III: Generalizability of prediction models 91.3.4 Part IV: Applications 9Part I: Prediction models in medicine 11Chapter 2 Applications of prediction models 132.1 Applications: medical practice and research 132.2 Prediction models for Public Health 142.2.1 Targeting of preventive interventions 14*2.2.2 Example: prediction for breast cancer 142.3 Prediction models for clinical practice 172.3.1 Decision support on test ordering 17*2.3.2 Example: predicting renal artery stenosis 172.3.3 Starting treatment: the treatment threshold 20*2.3.4 Example: probability of deep venous thrombosis 202.3.5 Intensity of treatment 21*2.3.6 Example: defining a poor prognosis subgroup in cancer 222.3.7 Cost-effectiveness of treatment 232.3.8 Delaying treatment 23*2.3.9 Example: spontaneous pregnancy chances 242.3.10 Surgical decision-making 26*2.3.11 Example: replacement of risky heart valves 272.4 Prediction models for medical research 282.4.1 Inclusion and stratification in a RCT 28*2.4.2 Example: selection for TBI trials 292.4.3 Covariate adjustment in a RCT 302.4.4 Gain in power by covariate adjustment 31*2.4.5 Example: analysis of the GUSTO-III trial 322.4.6 Prediction models and observational studies 322.4.7 Propensity scores 33*2.4.8 Example: statin treatment effects 342.4.9 Provider comparisons 35*2.4.10 Example: ranking cardiac outcome 352.5 Concluding remarks 35Chapter 3 Study design for prediction modeling 373.1 Studies for prognosis 373.1.1 Retrospective designs 37*3.1.2 Example: predicting early mortality in esophageal cancer 373.1.3 Prospective designs 38*3.1.4 Example: predicting long-term mortality in esophageal cancer 393.1.5 Registry data 39*3.1.6 Example: surgical mortality in esophageal cancer 393.1.7 Nested case-control studies 40*3.1.8 Example: perioperative mortality in major vascular surgery 403.2 Studies for diagnosis 413.2.1 Cross-sectional study design and multivariable modeling 41*3.2.2 Example: diagnosing renal artery stenosis 413.2.3 Case-control studies 41*3.2.4 Example: diagnosing acute appendicitis 423.3 Predictors and outcome 423.3.1 Strength of predictors 423.3.2 Categories of predictors 423.3.3 Costs of predictors 433.3.4 Determinants of prognosis 443.3.5 Prognosis in oncology 443.4 Reliability of predictors 453.4.1 Observer variability 45*3.4.2 Example: histology in Barrett’s esophagus 453.4.3 Biological variability 463.4.4 Regression dilution bias 46*3.4.5 Example: simulation study on reliability of a binary predictor 463.4.6 Choice of predictors 473.5 Outcome 473.5.1 Types of outcome 473.5.2 Survival endpoints 48*3.5.3 Examples: 5-year relative survival in cancer registries 483.5.4 Composite endpoints 49*3.5.5 Example: composite endpoints in cardiology 493.5.6 Choice of prognostic outcome 493.5.7 Diagnostic endpoints 49*3.5.8 Example: PET scans in esophageal cancer 503.6 Phases of biomarker development 503.7 Statistical power and reliable estimation 513.7.1 Sample size to identify predictor effects 513.7.2 Sample size for reliable modeling 533.7.3 Sample size for reliable validation 553.8 Concluding remarks 55Chapter 4 Statistical models for prediction 574.1 Continuous outcomes 57*4.1.1 Examples of linear regression 584.1.2 Economic outcomes 58*4.1.3 Example: prediction of costs 584.1.4 Transforming the outcome 584.1.5 Performance: explained variation 594.1.6 More flexible approaches 604.2 Binary outcomes 614.2.1 R2 in logistic regression analysis 624.2.2 Calculation of R2 on the log likelihood scale 634.2.3 Models related to logistic regression 654.2.4 Bayes rule 654.2.5 Prediction with Naïve Bayes 664.2.6 Calibration and Naïve Bayes 67*4.2.7 Logistic regression and Bayes 674.2.8 Machine learning: more flexible approaches 684.2.9 Classification and regression trees 69*4.2.10 Example: mortality in acute MI patients 694.2.11 Advantages and disadvantages of tree models 704.2.12 Trees versus logistic regression modeling 70*4.2.13 Other methods for binary outcomes 714.2.14 Summary on binary outcomes 724.3 Categorical outcomes 734.3.1 Polytomous logistic regression 734.3.2 Example: histology of residual masses 73*4.3.3 Alternative models 75*4.3.4 Comparison of modeling approaches 764.4 Ordinal outcomes 774.4.1 Proportional odds logistic regression 77* 4.4.2 Relevance of the proportional odds assumption in RCTs 784.5 Survival outcomes 804.5.1 Cox proportional hazards regression 804.5.2 Prediction with Cox models 814.5.3 Proportionality assumption 814.5.4 Kaplan-Meier analysis 81*4.5.5 Example: impairment after treatment of leprosy 824.5.6 Parametric survival 82*4.5.7 Example: replacement of risky heart valves 834.5.8 Summary on survival outcomes 834.6 Competing risks 844.6.1 Actuarial and actual risks 844.6.2 Absolute risk and the Fine&Gray model 844.6.3 Example: Prediction of coronary heart disease incidence 854.6.4 Multi-state modeling 864.7 Dynamic predictions 874.7.1 Multi-state models and landmarking 874.7.2 Joint models 874.8 Concluding remarks 88Chapter 5 Overfitting and optimism in prediction models 915.1 Overfitting and optimism 915.1.1 Example: surgical mortality in esophagectomy 925.1.2 Variability within one center 925.1.3 Variability between centers: noise vs. true heterogeneity 935.1.4 Predicting mortality by center: shrinkage 945.2 Overfitting in regression models 955.2.1 Model uncertainty and testimation bias 955.2.2 Other modeling biases 975.2.3 Overfitting by parameter uncertainty 975.2.4 Optimism in model performance 985.2.5 Optimism-corrected performance 995.3 Bootstrap resampling 1005.3.1 Applications of the bootstrap 1015.3.2 Bootstrapping for regression coefficients 1025.3.3 Bootstrapping for prediction: optimism correction 1025.3.4 Calculation of optimism-corrected performance 103*5.3.5 Example: Stepwise selection in 429 patients 1045.4 Cost of data analysis 105*5.4.1 Degrees of freedom of a model 1055.4.2 Practical implications 1055.5 Concluding remarks 106Chapter 6 Choosing between alternative models 1096.1 Prediction with statistical models 1096.1.1 Testing of model assumptions and prediction 1106.1.2 Choosing a type of model 1106.2 Modeling age – outcome relations 111*6.2.1 Age and mortality after acute MI 111*6.2.2 Age and operative mortality 112*6.2.3 Age – outcome relations in other diseases 1156.3 Head-to-head comparisons 1166.3.1 StatLog results 116*6.3.2 Cardiovascular disease prediction comparisons 117*6.3.3 Traumatic brain injury modeling results 1196.4 Concluding remarks 120Part II: Developing valid prediction models 123Checklist for developing valid prediction models 124Chapter 7 Missing values 1257.1 Missing values and prediction research 1257.1.1 Inefficiency of complete case analysis 1267.1.2 Interpretation of CC Analyses 1277.1.3 Missing data mechanisms 1277.1.4 Missing outcome data 1287.1.5 Summary points 1297.2 Prediction under MCAR, MAR and MNAR mechanisms 1307.2.1 Missingness patterns 1307.2.2 Missingness and estimated regression coefficients 1327.2.4 Missingness and estimated performance 1347.3 Dealing with missing values in regression analysis 1357.3.1 Imputation principle 1357.3.2 Simple and more advanced single imputation methods 1367.3.3 Multiple imputation 1377.4 Defining the imputation model 1387.4.1 Types of variables in the imputation model 138*7.4.2 Transformations of variables 1397.4.3 Imputation models for SI 1397.4.4 Summary points 1397.5 Success of imputation under MCAR, MAR and MNAR 1407.5.1 Imputation in a simple model 1407.5.2 Other simulation results 140* 7.5.3 Multiple predictors 1407.6 Guidance to dealing with missing values in prediction research 1427.6.1 Patterns of missingness 1427.6.2 Simple approaches 1437.6.3 More advanced approaches 1437.6.4 Maximum fraction of missing values before omitting a predictor 1437.6.5 Single or multiple imputation for predictor effects? 1447.6.6 Single or multiple imputation for deriving predictions? 1457.6.7 Missings and predictions for new patients 145*7.6.8 Performance across multiple imputed data sets 1467.6.9 Reporting of missing values in prediction research 1467.7 Concluding remarks 1487.7.1 Summary statements 148*7.7.2 Available software and challenges 149Chapter 8 Case study on dealing with missing values 1518.1 Introduction 1518.1.1 Aim of the IMPACT study 1518.1.2 Patient selection 1528.1.3 Potential predictors 1528.1.4 Coding and time dependency of predictors 1538.2 Missing values in the IMPACT study 1538.2.1 Missing values in outcome 1538.2.2 Quantification of missingness of predictors 1548.2.3 Patterns of missingness 1568.3 Imputation of missing predictor values 1598.3.1 Correlations between predictors 1598.3.2 Imputation model 1608.3.3 Distributions of imputed values 160*8.3.4 Multilevel imputation 1618.4 Predictor effect: adjusted analyses 1628.4.1 Adjusted analysis for complete predictors: age and motor score 1638.4.2 Adjusted analysis for incomplete predictors: pupils 1658.5 Predictions: multivariable analyses 165*8.5.1 Multilevel analyses 1668.6 Concluding remarks 166Chapter 9 Coding of categorical and continuous predictors 1699.1 Categorical predictors 1699.1.1 Examples of categorical coding 1709.2 Continuous predictors 171*9.2.1 Examples of continuous predictors 1719.2.2 Categorization of continuous predictors 1729.3 Non-linear functions for continuous predictors 1739.3.1. Polynomials 1739.3.2. Fractional polynomials (FP) 1749.3.3 Splines 175*9.3.4 Example: functional forms with RCS or FP 1769.3.5 Extrapolation and robustness 1769.3.5 Preference for FP or RCS? 1769.4 Outliers and winsorizing 1779.4.1 Example: glucose values and outcome of TBI 1789.5 Interpretation of effects of continuous predictors 180*9.5.1 Example: predictor effects in TBI 1819.6 Concluding remarks 1829.6.1 Software 183Chapter 10 Restrictions on candidate predictors 18510.1 Selection before studying the predictor – outcome relation 18510.1.1 Selection based on subject knowledge 185*10.1.2 Examples: too many candidate predictors 18510.1.3 Meta-analysis for candidate predictors 186*10.1.4 Example: predictors in testicular cancer 18610.1.5 Selection based on distributions 18610.2 Combining similar variables 18710.2.1 Subject knowledge for grouping 18710.2.2 Assessing the equal weights assumption 18810.2.3 Biologically motivated weighting schemes 18910.2.4 Statistical combination 18910.3 Averaging effects 190*10.3.1 Example: Chlamydia trachomatis infection risks 190*10.3.2 Example: acute surgery risk relevant for elective patients? 190*10.4 Case study: family history for prediction of a genetic mutation 19110.4.1 Clinical background and patient data 19110.4.2 Similarity of effects 19110.4.3 CRC and adenoma in a proband 19410.4.5 Full prediction model for mutations 19610.5 Concluding remarks 197Chapter 11 Selection of main effects 19911.1 Predictor selection 19911.1.1 Reduction before modeling 19911.1.2 Reduction while modeling 20011.1.3 Collinearity 20011.1.4 Parsimony 20011.1.5 Non-significant candidate predictors 20111.1.6 Summary points on predictor selection 20111.2 Stepwise selection 20211.2.1 Stepwise selection variants 20211.2.2 Stopping rules in stepwise selection 20211.3 Advantages of stepwise methods 20311.4 Disadvantages of stepwise methods 20411.4.1 Instability of selection 20411.4.2 Testimation: Biased in selected coefficients 206*11.4.3 Testimation: empirical illustrations 20711.4.4 Misspecification of variability and p-values 20811.5 Influence of noise variables 21011.6 Univariate analyses and model specification 21111.6.1 Pros and cons of univariate pre-selection 211*11.6.2 Testing of predictors in a domain 21211.7 Modern selection methods 212*11.7.1 Bootstrapping for selection 212*11.7.2 Bagging and boosting 212*11.7.3 Bayesian model averaging (BMA) 21311.7.4 Shrinkage of regression coefficients to zero 21311.8 Concluding remarks 214Chapter 12 Assumptions in regression models: Additivity and linearity 21712.1 Additivity and interaction terms 21712.1.1 Potential interaction terms to consider 21812.1.2 Interactions with treatment 21812.1.3 Other potential interactions 219*12.1.4 Example: time and survival after valve replacement 22012.2 Selection, estimation and performance with interaction terms 22012.2.1 Example: age interactions in GUSTO-I 22012.2.2 Estimation of interaction terms 22112.2.3 Better prediction with interaction terms? 22212.2.4 Summary points 22312.3 Non-linearity in multivariable analysis 22312.3.1 Multivariable restricted cubic splines (rcs) 22412.3.2 Multivariable fractional polynomials (FP) 22512.3.3 Multivariable splines in gam 22512.4 Example: non-linearity in testicular cancer case study 226*12.4.1 Details of multivariable FP and gam analyses 227*12.4.2 GAM in univariate and multivariable analysis 228*12.4.3 Predictive performance 229*12.4.4 R code for non-linear modeling in testicular cancer example 23012.5 Concluding remarks 23012.5.1 Recommendations 231Chapter 13 Modern estimation methods 23313.1 Predictions from regression and other models 233*13.1.1 Estimation with other modeling approaches 23413.2 Shrinkage 23413.2.1 Uniform shrinkage 23513.2.2 Uniform shrinkage: illustration 23613.3 Penalized estimation 236*13.3.1 Penalized maximum likelihood estimation 23713.3.2 Penalized ML: illustration 238*13.3.3 Optimal penalty by bootstrapping 23813.3.4 Firth regression 239*13.3.5 Firth regression: illustration 239*13.4.1 Estimation of a LASSO model 24013.5 Elastic net 241*13.5.1 Estimation of Elastic Net model 24113.6 Performance after shrinkage 24213.6.1 Shrinkage, penalization, and model selection 24213.7 Concluding remarks 244Chapter 14 Estimation with external information 247Background 24714.1 Combining literature and individual patient data (IPD) 24714.1.1 A global prediction model 248*14.1.2 A global model for traumatic brain injury 24914.1.3 Developing a local prediction model 24914.1.4 Adaptation of univariate coefficients 250*14.1.5 Adaptation method 1 250*14.1.6 Adaptation method 2 251*14.1.7 Estimation of adaptation factors 251*14.1.8 Simulation results 25214.1.9 Performance of the adapted model 25314.2 Case study: prediction model for AAA surgical mortality 25414.2.1 Meta-analysis 25414.2.2 Individual patient data analysis 25514.2.3 Adaptation and clinical presentation 25614.3 Alternative approaches 25714.3.1 Overall calibration 25714.3.2 Stacked regressions 25714.3.3 Bayesian methods: using data priors to regression modeling 25714.3.4 Example: predicting neonatal death 258*14.3.5 Example: aneurysm study 25814.4 Concluding remarks 258Chapter 15 Evaluation of performance 26115.1 Overall performance measures 26115.1.1 Explained variation: R2 26115.1.2 Brier score 26215.1.3 Performance of testicular cancer prediction model 26315.3.4 Assessment of moderate calibration 28315.3.5 Assessment of strong calibration 28315.3.6 Calibration of survival predictions 28415.3.7 Example: calibration in testicular cancer prediction model 285*15.3.8 R code for assessing calibration 28615.3.9 Calibration and discrimination 28615.4 Concluding remarks 28715.4.1 Bibliographic notes 287Chapter 16 Evaluation of clinical usefulness 28916.1 Clinical usefulness 28916.1.1 Intuitive approach to the cutoff 29016.1.2 Decision-analytic approach: benefit vs harm 29016.1.3 Accuracy measures for clinical usefulness 29116.1.4 Decision curve analysis 29216.1.5 Interpreting net benefit in decision curves 29316.1.6 Example: clinical usefulness of prediction in testicular cancer 29516.1.7 Decision curves for testicular cancer example 29616.1.8 Verification bias and clinical usefulness 297*16.1.9 R code 29816.2 Discrimination, calibration, and clinical usefulness 30016.2.1 Discrimination, calibration, and Net Benefit in the testicular cancer case study 30016.2.2 Aims of prediction models and performance measures 30116.2.2 Summary points 30216.3 From prediction models to decision rules 30316.3.1 Performance of decision rules 30316.3.2 Treatment benefit in prognostic subgroups 30516.3.3 Evaluation of classification systems 30516.4 Concluding remarks 306Chapter 17 Validation of prediction models 30917.1 Internal versus external validation, and validity 30917.1.1 Assessment of internal and external validity 31017.2 Internal validation techniques 31117.2.1 Apparent validation 31117.2.3 Cross-validation 31317.2.4 Bootstrap validation 31417.2.5 Internal validation combined with imputation 31517.3 External validation studies 31517.3.1 Temporal validation 316*17.3.2 Example: validation of a model for Lynch syndrome 31617.3.3 Geographic validation 31717.3.4 Fully independent validation 31917.3.5 Reasons for poor validation 32017.4 Concluding remarks 321Chapter 18 Presentation formats 32318.1 Prediction models versus decision rules 32318.2 Clinical prediction models 32518.2.1 Regression formulas 32518.2.2 Confidence intervals for predictions 32618.2.3 Nomograms 32718.2.4 Score chart 32918.2.5 Tables with predictions 33018.2.6 Specific formats 33118.2.7 Black box presentations 33118.3 Case study: clinical prediction model for testicular cancer model 33318.3.1 Regression formula from logistic model 33318.3.2 Nomogram 334*18.3.3 Score chart 33418.3.4 Summary points 33518.4 Clinical decision rules 33518.4.1 Regression tree 33518.4.2 Score chart rule 33518.4.3 Survival groups 33618.4.4 Meta-model 33718.5 Concluding remarks 338Part III: Generalizability of prediction models 341Chapter 19 Patterns of external validity 34319.1 Determinants of external validity 34319.1.1 Case-mix 34319.1.2 Differences in case-mix 34319.1.3 Differences in regression coefficients 34419.2.1 Simulation set-up 34519.2.2 Performance measures 34719.3 Distribution of predictors 34819.3.1 More or less severe case-mix according to X 348*19.3.2 Interpretation of testicular cancer validation 34919.3.3 More or less heterogeneous case-mix according to X 34919.3.4 More or less severe case-mix according to Z 35019.3.5 More or less heterogeneous case-mix according to Z 35119.4 Distribution of observed outcome y 35319.5 Coefficients β 35419.5.1 Coefficient of linear predictor < 1 35419.5.2 Coefficients β different 35519.6 Summary of patterns of invalidity 35619.6.1 Other scenarios of invalidity 35719.7 Reference values for performance 35819.7.1 Model-based performance: performance if the model is valid 35819.7.2 Performance with refitting 358*19.7.3 Examples: testicular cancer and TBI 359*19.7.4 R code 36019.8 Limited validation sample size 36119.8.1 Uncertainty in validation of performance 361*19.8.2 Estimating standard errors in validation studies 36319.8.3 Summary points 36319.9 Design of external validation studies 36319.9.1 Power of external validation studies 364*19.9.2 Calculating sample sizes for validation studies 36519.9.3 Rules for sample size of validation studies 36619.9.4 Summary points 36719.10 Concluding remarks 368Chapter 20 Updating for a new setting 37120.1 Updating only the intercept 37220.1.1 Simple updating methods 37220.2 Approaches to more extensive updating 37220.2.1 Eight updating methods for predicting binary outcomes 37320.3 Validation and updating in GUSTO-I 37520.3.1 Validity of TIMI-II model for GUSTO-I 37620.3.2 Updating the TIMI-II model for GUSTO-I 37720.3.3 Performance of updated models 378*20.3.4 R code for updating methods 37920.4 Shrinkage and updating 37920.4.1 Shrinkage towards recalibrated values in GUSTO-I 380*20.4.2 R code for shrinkage and penalization in updating 38120.4.4 Bayesian updating 38220.5 Sample size and updating strategy 383*20.5.1 Simulations of sample size, shrinkage, and updating strategy 38420.5.2 A closed test for the choice of updating strategy 38620.6 Validation and updating of tree models 38620.7 Validation and updating of survival models 388*20.7.1 Validation of a simple index for non-Hodgkin's lymphoma 38820.7.2 Updating the prognostic index 38920.7.3 Recalibration for groups by time points 38920.7.4 Recalibration with a Cox or Weibull regression model 39020.7.6 Summary points 39120.8 Continuous updating 392*20.8.1 Precision and updating strategy 392*20.8.2 Continuous updating in GUSTO-I 393*20.8.3 Other dynamic modeling approaches 39420.9 Concluding remarks 396*20.9.1 Further illustrations of updating 397Chapter 21 Updating for multiple settings 40121.1 Differences in outcome 40121.1.1 Testing for calibration-in-the large 401*21.1.2 Illustration of heterogeneity in GUSTO-I 40221.1.3 Updating for better calibration-in-the large 40321.1.4 Empirical Bayes estimates 403*21.1.5 Illustration of updating in GUSTO-I 40421.1.6 Testing and updating of predictor effects 405*21.1.7 Heterogeneity of predictor effects in GUSTO-I 405*21.1.8 R code for random effect analyses in GUSTO-I 40521.2 Provider profiling 40621.2.1 Ranking of centers: the expected rank 407*21.2.2 Example: provider profiling in stroke 408*21.2.4 Estimation and interpreting differences between centers 409*21.2.5 Ranking of centers 410*21.2.6 R code for provider profiling 41121.3 Concluding remarks 412*21.3.1 Further literature 413Part IV: Applications 415Chapter 22 Case study on a prediction of 30-day mortality 41722.1 GUSTO-I study 41722.1.1 Acute myocardial infarction 417*22.1.2 Treatment results from GUSTO-I 41822.1.3 Prognostic modeling in GUSTO-I 41822.2 General considerations of model development 42122.2.1 Research question and intended application 42122.2.2 Outcome and predictors 42122.2.3 Study design and analysis 42122.3 Seven modeling steps in GUSTO-I 42322.3.1 Preliminary 42322.3.2 Coding of predictors 42322.3.3 Model specification 42322.3.4 Model estimation 42322.3.5 Model performance 42422.3.6 Model validation 42422.3.7 Presentation 42522.3.8 Predictions 42622.4 Validity 42822.4.1 Internal validity: overfitting 42822.4.2 External validity: generalizability 42822.4.3 Summary points 42922.5 Translation into clinical practice 42922.5.1 Score chart for choosing thrombolytic therapy 42922.5.2 From predictions to decisions 43022.6 Concluding remarks 432Chapter 23 Case study on survival analysis: prediction of cardiovascular events 43523.1 Prognosis in the SMART study 435*23.1.1 Patients in SMART 43623.2 General considerations in SMART 43823.2.1 Research question and intended application 43823.2.2 Outcome and predictors 43823.2.3 Study design and analysis 43823.3 Preliminary modeling steps in the SMART cohort 44023.3.1 Patterns of missing values 44023.3.2 Imputation of missing values 44123.3.3 R code 44223.4 Coding of predictors 44323.4.1 Extreme values 44323.4.2 Transforming continuous predictors 44423.4.3 Combining predictors with similar effects 44523.4.4 R code 44623.5.1 A full model 44723.5.2 Impact of imputation 44923.5.3 R code for full model and imputation variants 44923.6 Model selection and estimation 45123.6.1 Stepwise selection 45123.6.2 LASSO for selection with imputed data 45223.7 Model performance and internal validation 45323.7.1 Estimation of optimism in performance 45323.7.2 Model presentation 45623.7.3 R code for presentations 45723.8 Concluding remarks 458Chapter 24 Overall lessons and data sets 46124.1 Sample size 46124.1.1 Model selection, estimation, and sample size 46224.1.2 Calibration improvement by penalization 46324.1.3 Poorer performance with more predictors 46424.1.4 Model selection with noise predictors 46524.1.5 Potential solutions 46624.1.6 R code for model selection and penalization 46624.2 Validation 46724.2.1 Examples of internal and external validation 46724.3 Subject matter knowledge versus machine learning 46824.3.1 Exploiting subject matter knowledge 46824.3.2 Machine learning and Big Data 47024.4 Reporting of prediction models and risk of bias assessments 47024.4.1 Reporting guidelines 47024.4.2 Risk of bias assessment 47224.5 Data sets 47324.5.1 GUSTO-I prediction models 47324.5.2 SMART case study 47524.5.3 Testicular cancer case study 47624.5.4 Abdominal aortic aneurysm case study 47824.6 Concluding remarks 481References 483

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Book SynopsisThis comprehensive third edition provides robust support to clinicians providing perioperative care for patients. Patients with a range of medical conditions undergo surgeries of varying levels of risk, and the evolving field of consult medicine aims to address their needs, whether pre- or post-surgery. This book offers evidence and experience-based information, advice, and guidelines on all aspects of perioperative medicine. Care around surgeries in many major clinical areas are included, including cardiology, pulmonology, gastroenterology, rheumatology, endocrinology, and so on. This new edition has been updated throughout with the latest literature, more visual content (tables and algorithms), and eleven new chapters on topics such as: chronic pain, congestive heart failure, hormone therapy and transgender patients, and postoperative hypoxemia. This new edition focuses on high value care in order to improve outcomes, including minimizing complications and readmissions. It also provides streamlined key points for caring for patients with medical diagnoses that may be especially complicated around surgery. This resource is invaluable for practicing physicians (including medical consultants, surgeons, and anesthesiologists) and other professionals who aim to optimize care of surgical patients.Trade ReviewTable of ContentsIntroduction.- The Preoperative Evaluation.- Perioperative Medication Management.- Anesthesia Fundamentals.- Cardiovascular Risk Stratification.- Ischemic Heart Disease.- Congestive Heart Failure.- Atrial Fibrillation.- Hypertension.- Valvular Heart Disease.- Implantable Cardiac Devices.- Diabetes.- Stress Dose Steroids.- Thyroid Disease.- Hormone Therapy and Transgender Patients.- Liver Disease.- Inflammatory Bowel Disease.- Chronic Anticoagulation.- Disorders of Hemostasis.- Thrombophilias.- Thrombocytopenia.- Anemia.- Sickle Cell Disease.- Venous Thromboembolic Disease.- Cerebrovascular Disease.- Epilepsy and Seizure Disorders.- Parkinson’s Disease.- Spinal Cord Injury.- Chronic Pain.- Pulmonary Risk Assessment and Management.- Asthma and COPD.- Obstructive Sleep Apnea / Obesity Hypoventilation Syndrome.- Pulmonary Hypertension.- Special Topics in Lung Disease: Restrictive, Myesthenia Gravis.- Chronic Kidney Disease.- Acute Kidney Injury.- Rheumatoid Arthritis.- Systemic Lupus Erythematosus.- Gout and Pseudogout.- Decision-Making Capacity.- Elderly Patients and Frailty.- Nutrition.- Patients with Solid Organ Transplant.- Substance Use and Dependence.- Postoperative Evaluation and Care.- Postoperative Fever.- Postoperative Delirium.- Postoperative Ileus.- Postoperative Hypoxemia.- Postoperative Tachycardia.- Postoperative Emergencies.- Postoperative Electrolyte Abnormalities.- Acute Pain Management Pearls.- Surgical Procedures Overview.

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Book SynopsisThis book serves as a tool for general psychiatrists, medical students, residents, and fellows looking for a clinically relevant and high-yield overview of addiction psychiatry in preparation for their board exams – or for everyday clinical practice. Written by expert educators in addiction psychiatry, the text is organized by substances misused and populations affected. This book serves as both a primary learning tool for those new to the field, as well as a reference for those working in addiction treatment. Each chapter begins with summaries of high yield clinical pearls, followed by general information including treatment, and then ends with accompanying board-style review questions. The scope includes understanding substances of misuse and substance use disorders (SUDs), how to evaluate, diagnose, and monitor SUDs, how to treat SUDs both pharmacologically and behaviorally, and critical information for specific populations of patients. Absolute Addiction Psychiatry for Clinical Practice and Review is an excellent resource for all medical students, residents, fellows, and professionals taking certification exams in addiction, including those in psychiatry, addiction medicine, emergency medicine, internal medicine, pain medicine, and others. The chapter "Laboratory Testing for Substance Use Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of ContentsPart 1- Diagnosis, Treatment Modalities and Settings, Recovery 1. Evaluation and diagnosis of Substance Use Disorder 2. Addiction Treatment Settings and Levels of Care 3. Recovery from Addiction and Treatment Moniotring 4. Non-pharmacologic Treatment across Substances 5. Special Focus: Issues in the US Opioid Epidemic Part 2- Substances and their Treatments 6. Nicotine 7. Alcohol 8. Benzodiazepines 9. Cannabis 10. Opioids 11. Stimulants- Cocaine and Amphetamines 12. Steroids, Dissociatives, Club Drugs, Inhalants, Hallucinogens Part 3- Populations 13. Adolescents and Students 14. Women and Pregnancy 15. Lesbian, Gay, Bisexual, Trans (LGBT) 16. Underserved Populations 17. Older Adults 18. Co-occurring Medical Disorders 19. Co-occurring Psychiatric Disorders

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Book SynopsisAdministrators and faculty in medical, nursing and health science programs are witnessing a substantial increase in the number of students with disabilities entering their programs. Concurrently, the benefits of diversity in healthcare are becoming increasingly apparent and important. Provider-patient concordance is a known mechanism for reducing health care disparities. By developing a workforce that mirrors the patient population, we can appropriately inform disability care, reducing health care disparities while embracing the tenets of the Americans With Disabilities Act (ADA), namely equal opportunity, full participation, independent living, and economic self-sufficiency for qualified individuals with disabilities. One in five individuals will experience disability at some point in their lives, making this the largest minority in the US. A commitment to disability inclusion for qualified students should be a high-level goal of nursing, medical, and other health science programs. To support this goal, leaders in these areas must develop robust programs and an understanding of the best practices for inclusion. This first-of-its-kind title is designed to help deans, program directors, faculty, student affairs personnel and disability resource professionals thoughtfully plan for the growing population of health-care professionals with disabilities. The content helps stakeholders contextualize disability inclusion in health-care education as a function of social justice and a mechanism of reducing health care disparities for patients. It offers pragmatic advice, grounded in research, best practice, and case law to address the highly nuanced approach to determining and implementing accommodations in a high-stakes clinical environment. Disability as Diversity connects the moving parts necessary to ensure equal access for qualified students and provides a blueprint for crafting policy, proactive messaging, improving climate, adhering to accreditation standards, addressing licensing and board exams, responding to student failure, all while remaining compliant with the Americans with Disabilities Act (ADA), and applicable Federal regulations. This text provides educators with the perspectives and skills they need to bring disability inclusion to the forefront of health education. Table of ContentsForewordIntroductionChapter 1: Frameworks for InclusionChapter 2: Healthcare Disparities for Individuals with DisabilityChapter 3: Intersectional IdentitiesChapter 4: Creating a program within a culture of inclusionChapter 5: Wellness and disabilityChapter 6: Realizing Academic Success within the Health Science Learning EnvironmentChapter 7: Increasing Accessibility Through Inclusive Instruction and DesignChapter 8: Health Professionals and the Law Chapter 9: Technical StandardsChapter 10: Clinical Accommodations and SimulationChapter 11: When Students Fail: Remediation and Dismissal in Nursing and MedicineChapter 12: Physician Licensing, Career and PracticeChapter 13: Licensing, Career and Practice in Nursing

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Book SynopsisThis book comprehensively addresses female and male fertility preservation. It discusses in detail all major aspects of fertility preservation in both sexes, explains the basis of fertility preservation, and highlights the currently available techniques; further chapters are dedicated to specific diseases. The book offers an essential reference guide for all physicians, specialists or not, seeking to improve their grasp of female and male fertility preservation. Table of ContentsPart I FEMALE FERTILITY PRESERVATION Normal ovarian ageing.- The effect of chemotherapy and radiotherapy on female reproductive tract.- Pediatric cancer and fertility.- ART in cancer survivors: including egg donation.- Fertility sparing surgery in gynecologic cancers.- Ovarian transposition.- Hormonal suppression for ovarian protection.- Oocyte and embryo cryopreservation: methodology and clinical results.- Ovarian stimulation for fertility preservation (different protocols).- In vitro maturation of oocytes.- Ovarian tissue cryopreservation.- Techniques of ovarian transplantation.- Assessing safety in ovarian transplantation.- Whole ovary cryopreservation and transplantation.- Fertility preservation in breast cancer patients.- Fertility preservation and endometriosis.- Fertility preservation in autoimmune diseases.- Fertility preservation in transgender males.- Fertility preservation in Turner syndrome and other gonadal dysgeneses .- Tissue preparation and follicle activation by physical methods .- Fertility preservation in children and adolescents.- Social egg freezing.- Ovarian tissue banking to postpone menopause.- Endometrial stem cells transplantation.- Uterine transplantation.- Surrogacy.- Medical treatments for ovarian protection.- Transplantation of isolated follicles.- In vitro folliculogenesis.- Artificial ovary.- Gamete production from stem cells.- Part II MALE FERTILITY PRESERVATION Impact of cancer treatments on sperm chromatin integrity.- ART in cancer patients including sperm donation.- Sperm cryopreservation.- Indications and methods of Epididymal or Testicular sperm retrieval for cryopreservation.- Testis sparing surgery.- Hormonal suppression for FP in male.- Fertility preservation in hypogonadal men.- Fertility preservation in prepubertal boys.- Fertility preservation in transgender females.- Testicular tissue transplantation.- Removal of malignant cells prior to autotransplantation of spermatogonial stem cells.- Transplantation of cryopreserved spermatogonia.- In vitro spermatogenesis.- Part III FEMALE AND MALE FERTILITY PRESERVATION Psychological aspects of fertility preservation.- Ethical considerations of fertility preservation.- Legal aspects.

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Book SynopsisThis volume focuses on endometriosis from its pathogenesis and the importance of the early diagnosis to treatment, throughout all aspects of femininity that this disease affects, impacting health and quality of life.It also covers treatment strategies for the pain and for the disease management according to the age and needs of the patient, from adolescence to menopause, passing through the fertile age and the consequences that this disease can have on fertility and pregnancy. This book is a useful, clear and up-to-date tool for gynecologists, gynecological surgeons, reproductive medicine and general practitioners and is an important source of information to face this more and more frequent and devastating disease.Table of ContentsChapter 1. Endocrine disruptors and risk of endometriosis.- Chapter 2. Metabolomic characteristics in endometriosis patients.- Chapter 3. Can we diagnose early endometriosis with ultrasound rather than laparoscopy?.- Chapter 4. Neurotrophins and cytokines in endometriosis pain.- Chapter 5. Endometriosis induced pain: the treatment strategy.- Chapter 6. Management of endometriosis in teenagers.- Chapter 7. The etonogestrel contraceptive implant as a therapy for endometriosis.- Chapter 8. Impact of endometrioma surgery on ovarian reserve.- Chapter 9. What is the place of surgery of deep endometriosis in infertile and pelvic pain patients?.- Chapter 10. Endometriosis and Infertility: surgery and IVF: when, why and outcomes.- Chapter 11. ART and Endometriosis : problems and solutions.- Chapter 12. Morphokinetics in embryos from patients with endometriosis.- Chapter 13. Endometriosis and cancer: prevention and diagnosis.- Chapter 14. Medical management of endometriosis, present and future with special reference to MHT in the patient previously diagnosed with endometriosis.- Chapter 15. Endometriosis and Menopause: Realities and Management.

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Book SynopsisThis book brings together state of the art endosurgical techniques on abdominal, gastrointestinal, colorectal and thoracic operations in children, as well as operations of upper urological tract. Each chapter is complemented by a corresponding video of the described procedure, featuring critical maneuvers, useful tips, and alternative approaches. The book itself summarizes each operation, containing illustrations about positioning in the operation theatre, the most important steps of the surgical procedures and the managing of possible complications. The videos are accessible through different devices including desktop or laptop computers, tablets, as well as smartphones, allowing both novice and experienced surgeons to review the procedures on the go, during rounds, or in the operating room. The book and accompanying videos are therefore an invaluable guide for pediatric surgeons as well as young surgeons at the start of their career. Videos and more: Download the free Springer Nature More Media App - Scan dedicated images in this book to stream videos or access and download supplementary material.Table of ContentsAppendectomy 3 Trocar.- Intussusception.- Thoracoscopic hyperhydrosis treatment.- Sacrococcygeal teratoma resection.- Laparoscopic Nissen fundoplication.- Fundoplication Tupet.- Nutritional access procedures (gastrostomy, jejunostomy) .- Single Incision Pediatric Endosurgical (SIPES) Appendectomy.- Heller Myotomy.- Splenectomy SILS.- Splenectomy Multitrocar.- Inguinal hernia.- Epigastric hernia.- CDH.- H-Type Fistula.- Management of foregut cystic lesions (including bronchogenic cysts) .- Biopsy of Mediastinal Mass.- Laparoscopic Resection of choledochal cyst with hepaticojejunostomy.- Laparoscopic orchiopexy.- Laparoscopic management in Ulcerative Colitis: staged proctocolectomy with ileoanal pouch anastomosis.- Laparoscopic management in Crohn’s Disease: Ileocecal resection.- General oncologic endosurgical procedures.- Fundoplication Thal.- Pyloromyotomy.- Laparoscopic duodenal atresia repair.- Single-Incision Pediatric Endosurgery (SIPES) Appendectomy .- Laparoscopic Cholecystectomy.- Laparoscopic approach in anorectal malformations.- Laparoscopy for the surgical approach to Hirschsprung Disease.- Pulmonary Sequestration.- Chest wall anomalies.- Laparoscopic Pyeloplasty.- Laparoscopic transperitoneal simple nephrectomy.- Laparoscopic transperitoneal Heminephrectomy .- EXTRAVESICAL URETERAL REIMPLANTATION (LICH-GREGOIR).- Varicocelectomy.- Laparoscopic Adrenalectomy.- Thoracoscopic Lung Biopsy.- TEF Type A.- Ovarian procedures (torsion/ masses).- Thoracoscopic tracheoesophageal fistula and esophageal atresia repair.- VAPES malrotation.- VAPES liver biopsy.- Laparoscopic and open Kasai portoenterostomy for biliary atresia.- Thoracoscopic lung resection.- Thymectomy.- Treatment for Spontaneous Pneumothorax.- Partial Splenectomy.- Laparoscopic management of intra-abdominal testis Shehata Technique.- Two Stage laparoscopic assisted Fowler-Stephens orchidopexy.

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Book SynopsisThis book presents a case based approach to epilepsy management in both diagnostic challenges and treatment of complex cases. Cases reflect “real life” patient scenarios that practitioners encounter with up-to-date terminology and treatment approaches.With 51 chapters, the book presents 51 unique, nuanced cases. Beginning with an initial presentation of a case history, the book opens with a basis for drawing in multiple aspects in the treatment of patients with epilepsy. Each chapter is organized into a clinical history, physical examination results, and ancillary testing to concentrate on differential diagnosis and focus on a definitive procedural approach to the final diagnosis. Subsequent information about the condition expands on the knowledge of the clinical features to a solution of common patient clinical scenarios as it affects people with epilepsy.A comprehensive successor edition, Epilepsy Case Studies is an invaluable resource to clinicians ranging from those looking for a quick review of a topic present in the table of contents, to those crossing disciplines into medical areas where seizures are a symptom of disordered or dysfunctional brain.Table of ContentsCasesNeonatal onset-general (ie spasms)Neonatal onset-focal (hyperglycinemia)Febrile seizuresChildhood onset-general (CAE)Lennox-Gastaut syndromeChildhood onset-focal (BCECTS)Adolescent onset-general (JME)Adolescent onset-focal (unknown cause)Stigmatization Effect (social consequences)Physical and mental well-being (sports and education)Physical Comorbidity (CP)Mental Comorbidity (ADD/Austistic spectrum disorder)Etiologies of a foreign tissue lesion Head trauma Precipitating factors (triggers)Single seizure (treatment focus)Drug cessation (treatment focus)Epilepsy-adult (treatment focus)Epilepsy-elderly (treatment focus)Generic AEDs Side effects Drug interactionsBirth controlHormonal replacementPregnancy (treatment focus)Epileptic panic attacks (diagnosis)Anxiety-DepressionViolence (frontal lobe seizures) PNEA-women (diagnosis focus)PNEA-men (treatment focus)Drug-resistant-neurologically normal (“skip” surgery)Drug-resistant-neurologically normal but complex (invasive EEG)Drug-resistant surgical failure (treatment focus)Work and disabilityMemory lossStatus epilepticus-convulsiveStatus epilepticus-non-convulsiveSUDEPExperimental therapies (treatment)Alternative therapies (treatment)

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Book SynopsisImplementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems.The culture of safety in the care environment and of human factors influencing it should be developed from the beginning of medical studies and in the first years of professional practice, in order to have the maximum impact on clinicians' and nurses' behavior. Medical errors tend to vary with the level of proficiency and experience, and this must be taken into account in adverse events prevention. Human factors assume a decisive importance in resilient organizations, and an understanding of risk control and containment is fundamental for all medical and surgical specialties. This open access book offers recommendations and examples of how to improve patient safety by changing practices, introducing organizational and technological innovations, and creating effective, patient-centered, timely, efficient, and equitable care systems, in order to spread the quality and patient safety culture among the new generation of healthcare professionals, and is intended for residents and young professionals in different clinical specialties.Table of ContentsPart I. Introduction.- 1. Guidelines and Safety Practices for Improving Patient Safety.- 2. Brief story of a clinical risk manager.- 3. Human Error and Patient Safety.- 4. Looking forward to the future.- 5. Safer care: shaping the future.- 6. Patients for Patient Safety.- 7. Human Factors and Ergonomics in Health Care and Patient Safety from the Perspective of Medical Residents.- Part II. Background.- 8. Patient Safety in the World.- 9. Infection Prevention and Control.- 10. The patient journey.- 11. Adverse event investigation and risk assessment.- 12. From theory to real world integration: implementation science and beyond.- Part III. Patient safety in the main clinical specialties.- 13. Intensive care and anesthesiology.- 14. “Safe Surgery Saves Lives” .- 15. Emergency Department Clinical Risk.- 16. Obstetric Safety Patient.- 17. Patient Safety in the main clinical specialties.- 18. Risks in Oncology and Radiation Therapy.- 19. Orthopaedics and Traumatology.- 20.Patient Safety & Risk Management in Mental Health.- 21. Pediatrics.- 22. Patient safety in the main clinical specialties: Radiology.- 23. Organ Donor Risk Stratification in Italy.- 24. Patient Safety in Laboratory Medicine.- 25. Ophthalmology.- IV Healthcare organization.- 26. Community and Primary Care.- 27. Complexity science as a frame for understanding the management and delivery of high quality and safer care.- 28. Measuring clinical workflow to improve quality and safety.- 29. Shiftwork Organization.- 30. Non Technical Skills in Healthcare.- 31. Medication safety.- 32. Digital technology and usabililty and ergonomics of medical devices.- 33. Lessons learned from the Japan Obstetric Compensation System for Cerebral Palsy: A novel system of data aggregation, investigation, amelioration, and no-fault compensation.- 34. Coping with the COVID -19 pandemic: roles and responsibilities for preparedness.

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Book SynopsisThis unique and engaging open access title provides a compelling and ground-breaking account of the patient safety movement in the United States, told from the perspective of one of its most prominent leaders, and arguably the movement’s founder, Lucian L. Leape, MD. Covering the growth of the field from the late 1980s to 2015, Dr. Leape details the developments, actors, organizations, research, and policy-making activities that marked the evolution and major advances of patient safety in this time span. In addition, and perhaps most importantly, this book not only comprehensively details how and why human and systems errors too often occur in the process of providing health care, it also promotes an in-depth understanding of the principles and practices of patient safety, including how they were influenced by today’s modern safety sciences and systems theory and design. Indeed, the book emphasizes how the growing awareness of systems-design thinking and the self-education and commitment to improving patient safety, by not only Dr. Leape but a wide range of other clinicians and health executives from both the private and public sectors, all converged to drive forward the patient safety movement in the US. Making Healthcare Safe is divided into four parts: I. In the Beginning describes the research and theory that defined patient safety and the early initiatives to enhance it. II. Institutional Responses tells the stories of the efforts of the major organizations that began to apply the new concepts and make patient safety a reality. Most of these stories have not been previously told, so this account becomes their histories as well. III. Getting to Work provides in-depth analyses of four key issues that cut across disciplinary lines impacting patient safety which required special attention. IV. Creating a Culture of Safety looks to the future, marshalling the best thinking about what it will take to achieve the safe care we all deserve. Captivatingly written with an “insider’s” tone and a major contribution to the clinical literature, this title will be of immense value to health care professionals, to students in a range of academic disciplines, to medical trainees, to health administrators, to policymakers and even to lay readers with an interest in patient safety and in the critical quest to create safe care.Table of ContentsPart I. IN THE BEGINNING 1. The Hidden Epidemic The Harvard Medical Practice Study 2. It’s Not Bad People Error in Medicine 3. Changing the System The Adverse Drug Events Study 4. Coming Together The Annenberg Conference 5. A Home of Our Own The National Patient Safety Foundation Part II. INSTITUTIONAL RESPONSES 6. We Can Do This The Institute for Healthcare Improvement Adverse Drug Events Collaborative 7. Who Will Lead? The Executive Session 8. A Community of Concern The Massachusetts Coalition for the Prevention of Medical Errors 9. When the IOM Speaks IOM Quality of Care Committee and Report 10. The Government Responds The Agency for Healthcare Research and Quality 11. Setting Standards The National Quality Forum 12. Enforcing Standards The Joint Commission 13. Partners in Progress Patient Safety in the United Kingdom 14. Going Global The World Health Organization 15. Just Do It The Surgical Checklist 16. Spreading the Word The Salzburg Seminar 17. Publish or Perish British Medical Journal Theme issue, New England Journal of Medicine Series Part III. GETTING TO WORK Key issues and how they were dealt with 18. Sleepy Doctors Work hours and the Accreditation Council for Graduate Medical Education 19. A Conspiracy of Silence Disclosure, Apology, and Restitution 20. Who Can I Trust? Ensuring physician competence 21. Everyone Counts Building a culture of respect Part IV. CREATING A CULTURE OF SAFETY 22. Make No Little Plans The Lucian Leape Institute 23. Now the Hard Part Creating a culture of safety

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Book SynopsisThis is the second edition of the book originally published under the title Medical Emergencies Caused by Aquatic Animals: A Zoological and Clinical Guide. Including updated chapters, new content and additional references, it discusses follow-up with patients, describes diseases that are not emergencies and explains procedures that can take place at health stations and outpatient centers, focusing on clinical and biological aspects relevant to researchers and practitioners alike. The chapter on Invertebrate Aquatic Animals presents facts and advances that were left out of the first edition. In addition, it includes improved images. The subtopic on Cnidaria presents recent data on outbreaks and new species identification in unprecedented areas, with a timely discussion on first aid treatment. The chapter on Injuries by Vertebrate Aquatic Animals has been improved, based on continued work with bathers and fishermen. Featuring numerous images and representative clinical cases, it explores the most significant injuries caused by fish around the globe. The chapter on Ingestion of Aquatic Venomous Animals: Toxinology, Clinical Aspects, and Treatment discusses outbreaks of intoxication diseases from eating fish and seafood, drawing on reliable records of serial cases of Haff's syndrome, scombroidism and ciguatera. Further, it examines the indiscriminate consumption of aquatic animals, which the author argues present the same (or even greater) risks of poisoning and infections as terrestrial animals. Lastly, since there is a general lack of awareness of the risk of infections in aquatic environments, the chapter on Bacterial and Fungal Infections in Aquatic Environments describes the symptoms and treatments and highlights preventive measures.Table of Contents1. Introduction 2. Invertebrate Aquatic Animals 3. Injuries caused by Vertebrate Aquatic Animals 4. Ingestion of Aquatic Venomous Animals: Toxinology, Clinical Aspects, and Treatment 5. Bacterial and Fungal Infections in Aquatic Environments

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Book SynopsisLarge, successful organizations only transform after failure. If everything is going well, there is a tendency not to challenge methods. It is only once things have gone radically wrong that a successful organization starts to reexamine their methods and culture. This book is about organizational leadership, but provides a unique spin to promoting innovation, inclusion and transparency among employees.It examines co-author Steven Rotkoff’s experiences as a retired US Army Colonel and Red Team strategies used by the military and the corporate world to make better decisions and improve organizational culture and applies them to nursing in both clinical and academic settings. Centering cases derived from US-based academic and clinical settings, the book discusses how and why some strategies do and others don’t work and examines how these military and corporate strategies apply effectively to nursing settings. Turning a lot of the available literature on its head, this book offers new models and methods to foster better conversations, particularly between managers and staff.Nursing has changed in both academic and clinical settings. Just as military and corporate organizations have had to change their organizational behavior and leadership styles and methods to meet the needs of today’s employees and consumers, the nursing profession must change to meet the needs of faculty, an inter-professional health care environment and our increasingly inclusive and diverse environments.Table of ContentsPart One: Why Red Team?1. Nursing Leadership in a Segmented Discipline2. Why Red Teaming is a Better Way3. The Red Team Toolbox: Improving the conversation and changing the frame of reference4. The Red Team Tool Box: Understanding the Problem and Envisioning the Future5. Applying Red Team Tools Part Two: Cases6. Budget Cuts at Green University 7. Horizontal Violence in Pink Hospital 8. Strategic Planning at Yellow Institute 9. Who’s in Charge at Orange School of Nursing?10. Conflict between the front and back office staff at Purple Clinic11. Hierarchy at Blue University School of Nursing12. What to Build at Turquoise University School of Nursing13. Merging Brown Visiting Nurse Association with Gray Health SystemPart Three: Conclusion14. Conclusion

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Book SynopsisThe Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.Table of ContentsPart I. Respiratory Issues.- Part II. ARDS.- Part III. Biomarkers.- Part IV. Fluids.- Part V. Hemodynamic Management.- Part VI. An unknown pandemics.- Part VII. Covid-19 associated coagulopathy.- Part VIII. Sepsis.- Part IX. Bleeding & Transfusion.- Part X. Prehospital Intervention.- Part XI. Neurological Aspects.- Part XII. Organ Donation.- Part XIII. Oncology.- Part XIV. Severe Complications.- Part XV. Prolonged Critical Illness.- Part XVI. Organizational and Ethical Aspects.- Part XVII. Artificial intelligence in the ICU.- Index.

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Book SynopsisThis updated text provides a concise yet comprehensive and state-of-the-art review of evolving techniques in the new and exciting subspecialty of interventional urology. Significant advances in imaging technologies, diagnostic tools, fusion navigation, and minimally invasive image-guided therapies such as focal ablative therapies have expanded the interventional urologists’ clinical toolkit over the past decade. Organized by organ system with subtopics covering imaging technologies, interventional techniques, recipes for successful practice, pitfalls to shorten the learning curves for new technologies, and clinical outcomes for the vast variety of interventional urologic procedures, this second edition includes many more medical images as well as helpful graphics and reference illustrations. The second edition of Interventional Urology serves as a valuable resource for clinicians, interventional urologists, interventional radiologists, interventional oncologists, urologic oncologists, as well as scientists, researchers, students, and residents with an interest in interventional urology.Table of ContentsSection 1: History.- Section 2: Imaging Theory.- History/Background.- Imaging Theory for each Modality.- CBCT.- Break Downs by Organs.- Section 3: Fusion Theory.- Fusion Technology Basics.- Definitions.- Getting under the Hood.- How and Why we need Fusion.- Getting out of the Rectum.- Fusion Guidance for Focal and Whole Gland Ablation Prostate and Kidney.- Future Applications.- Generalized Applications of Imaging in Urology.- Section 4: Prostate.- Types of Prostate Imaging.- US.- BPH.- Cancer Imaging.- Diseases.- Renal Ablation.- Prostate Ablation.- Section 5: Kidney.- Imaging.- Biopsy.- Drainage VS Aspirations and Why.- Ablations.- Embolization.- Venography/Angiography.- Section 6: Bladder/Diversions/Ureter.- Diseases-Reflux, Cystitses, Bladder Cancer, Foreign Body, Diversions, Ureteral Strictures.- Imaging Correlations.- Treatments.- Section 7: Adrenal.- Diseases.- ACC/Adenoma/Adrenal Myelopoma/BAH/Conns/Cushings/Pheo.- Imaging Correlations.- Treatments.- Varicoceles.- Immuno-Therapy and IU.- Outcome Language/Cost Effectiveness Studies/ and Outcome Measures in IU.

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Book SynopsisThis book provides a clinically useful resource for evaluation and management of the symptoms and issues that burden survivors of breast cancer. Improvements to breast cancer screening and treatment have resulted in more patients than ever before having been cured after local definitive and systemic therapies. Primary care providers and specialists must be increasingly familiar with the issues that breast cancer survivors routinely face. This is the first book to provide a single resource for common issues faced by breast cancer survivors from a truly multidisciplinary perspective; each chapter of this text is coauthored by at least one oncologist and one specialist outside the field of oncology in order to include the perspectives of relevant disciplines. User-friendly and clinically applicable to all specialties, individual chapters also include tables and figures that describe how best to conduct initial evaluation of the given symptom as well as an algorithm, where applicable, outlining the optimal management approach. Common Issues in Breast Cancer Survivors: A Practical Guide to Evaluation and Management empowers non-cancer specialists and practitioners who care for breast cancer survivors to address common issues that impact patient quality of life. Table of ContentsOverview of the National and International Guidelines for Care of Breast Cancer Survivors.- Breast Imaging in Breast Cancer Survivors: Screening for New Breast Cancers and for Cancer Recurrence.- Hot Flashes.- Management of Genital Symptoms in Breast Cancer Survivors.- Sexual and Reproductive Health Concerns in Breast Cancer Survivors.- Arthralgias.- Persistent Breast Pain (PBP).- Common Issues in Breast Cancer Survivors – A Practical Guide to Evaluation and Management of Neuropathy.- Cancer-related Cognitive Impairment.- Cancer-Related Fatigue.- Sleep Issues and Insomnia.- Depressive and Anxiety Symptoms and Disorders in Women with Breast Cancer.- Obesity, Weight Gain and Weight Management in Women with Early Breast Cancer.- Breast Cancer-Related Lymphedema and Shoulder Impairments– Physical Therapy and Plastic Surgery.- Bone Loss in Breast Cancer Survivors.- Cardiovascular Health in Breast Cancer Survivors.- Diabetes and Breast Cancer.- Hair Loss in Breast Cancer Survivors.- Skin Reactions Associated with Breast Cancer Treatment.- Hereditary Cancer Counseling and Germline Genetic Testing.- Common Considerations in Male Breast Cancer Survivors: A Practical Guide to Evaluation and Management.

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Book SynopsisThis book provides a practical overview of osteoporosis for the wide spectrum of clinicians that might encounter the osteoporotic patient. Concise and well-structured chapters examine the public health importance of the condition, the current treatment gap, how to identify individuals who would benefit from treatment, bone turnover and how this can be modified by osteoporosis therapies, adjuvant lifestyle modification, the calcium and vitamin D story, antiresorptive therapies, anabolic therapies, emerging therapies, adherence and compliance with therapy and the perception of fracture risk. Osteoporosis Treatment: A Clinical Overview meets the need for a book that improves awareness of this major public health problem and possible therapeutic approaches. Primary care physicians, endocrinologists, rheumatologists, orthopaedic surgeons and those providing specialist care for the elderly will all benefit from this highly accessible and informative guide to treating osteoporosis.Table of ContentsThe epidemiology of fracture: why treatment matters.- The treatment gap.- How to identify those requiring fracture.- The Bone turnover cycle.- Antiresorptive therapies.- Anabolic therapies.- Emerging therapies.- Improving compliance.- Non-pharmacological therapies.

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Book SynopsisThis book discusses all aspects of non-pharmacologic approaches to primary and secondary CVD prevention. It highlights the strength of evidence for particular diet styles in CVD prevention, including plant-based diets, the Mediterranean diet, the DASH diet, and low-carbohydrate diets. Chapters present evidence and future directions for diet and nutrition in diseases related to CVD, such as dyslipidemia, cardiometabolic disease (pre-diabetes, the metabolic syndrome, type-2 diabetes mellitus), and obesity. Finally, the book reviews novel and emerging aspects of dietary intervention in CVD prevention, such as dietary approaches to inflammation and the role of the microbiome in CVD. Up-to-date, evidence-based, and clinically oriented, Prevention and Treatment of Cardiovascular Disease: Nutritional and Dietary Approaches is an essential resource for physicians, residents, fellows, and medical students in cardiology, clinical nutrition, family medicine, endocrinology, and lipidology.Table of ContentsPreface: Epidemiology and Basic Pathophysiology of Atherosclerosis and CVD Part I. General Considerations for Diet in Cardiovascular Health Chapter 1. Diet and Nutrition in the Prevention of Cardiovascular Disease: A Comprehensive Review of Current Evidence, Controversies, and Advice for the Practicing Clinician Authors: Michael Wilkinson (UCSD), Michael Garshick (NYU), Pam Taub (UCSD) Chapter 2. Role of Dietary Nutrition, Vitamins, and Nutrients in CV Health (Including Biomarkers of Nutrition Penny M. Kris-Etherton (Penn State) Chapter 3. The Mediterranean Diet Emilio Ros (PREDIMED (Hospital Clínic de Barcelona, Servicio de Endocrinología y Nutrición)) Chapter 4. Dietary Approach to Hypertension, Dietary Sodium, and the DASH Diet for CV Health Frank Sacks (Harvard: Chair of the Design Committee of the DASH study, Chair of the Steering Committee for the DASH-Sodium trial) Chapter 5. Diet Trends: Ketogenic Diet, Low-carb Diets, Paleo Diet James O’Keefe Jr (St Luke’s Mid America Heart Institute) Chapter 6. Overview of Plant-based Diets Caldwell Esselstyn (Cleveland Clinic) Chapter 7. Low-fat Diet Styles, Including the Ornish and Pritikin Diets Hannah Lo (UCSD) and Dean Ornish (UCSF) Chapter 8. Plant-based Oils Anne Goldberg (Wash U in St. Louis) Part II. Diet Considerations for Obesity and Cardiometabolic Disease Chapter 9. Dietary Strategies to Promote Weight Loss, Including Caloric Restriction as a Dietary Strategy, Bariatric Surgery, Adiposopathy and Dietary Strategies to Promote Loss of Visceral and Ectopic Fat Jose Aleman (NYU) and Holly Lofton (NYU) Chapter 10. Intermittent Fasting for CV Health Michael Wilkinson (UCSD) and Elizabeth Epstein (UCSD) Chapter 11. Optimal Diet for Metabolic Syndrome to Prevent Progression to Diabetes Larry Sperling (Emory) Chapter 12. Optimal Diet for Diabetes Ira Goldberg (NYU) (Alternate) Amit Majithia (UCSD) Chapter 13. Dietary Approaches to Inflammation Michael Garshick (NYU) with Nehal Mehta (NIH) or Paul Ridker (Brigham and Women’s Hospital) Part III. Dietary Considerations for Common Lipid Disorders Chapter 14. Dietary Approaches to Lowering LDL-C Michael Davidson (U Chicago) and Lane Benes (U Chicago) Chapter 15. Dietary Approaches to Lowering Triglycerides Howard Weintraub (NYU) Part IV. Additional Topics for Diet and Nutrition in Cardiovascular Disease Chapter 16. E-health and the Use of Mobile Devices and Smartphone Apps to Promote Heart-healthy Diets Jonathan Dodson (NYU) Chapter 17. Role of the Microbiome in CV Disease Stanley Hazen (Cleveland Clinic) Chapter 18. Dietary Considerations in CV Diseases: CHF Chapter 19. Dietary Considerations in CV Diseases: Arrhythmia Chapter 20. Dietary Considerations in the Elderly and Cardiovascular Health

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Book SynopsisElectronic cigarettes (E-cigarettes), also known as vape devices or by trade names such as JUUL, are handheld devices that aerosolize liquid commonly containing nicotine, humectants and flavorings. Used by 1 in 5 high school students in 2020, they are the most common tobacco product used by youth. E-cigarette use has been associated with a variety of health issues such as nicotine addiction, e-cigarette or vaping associated lung illness (EVALI), seizures, and increased risk of cardiovascular disease. This first-of-its-kind book begins with an introduction and background on the historical context of tobacco products. The next chapters provide an overview of the e-cigarette landscape and reviews the e-cigarette devices and solutions and the evolution of these products. This is followed by reviews of the health effects of e-cigarettes on users and non-users and includes recommendations for prevention and treatment of youth e-cigarette use. The last few chapters address the public health impact of e-cigarettes with a review of the evidence of e-cigarettes in smoking cessation. The book closes with policy and advocacy approaches and a resource page. E-cigarette and vape device use pose a public health crisis. This book contains succinct practical information and is a key reference for pediatricians as well as clinicians of all specialities. It also serves as a resource for health professionals, including tobacco dependence treatment providers and public health experts.Trade Review“A comprehensive guide to e-cigarettes and vape devices, such as this book, could be a very useful reference for dental professionals trying to increase their knowledge on this complex topic. This book covers a wide range of subjects, from the history and background of tobacco and novel products through to health effects, marketing/advertising, and regulation. … this book presents a very narrow viewpoint on e-cigarettes, generally being very negative towards them.” (Richard Holliday, Evidence-Based Dentistry, Vol. 24 (4), 2023)​Table of Contents

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Book SynopsisThis book provides a practical approach to cardiac perioperative care. The step-by-step format guides readers from basic concepts, such as cardiac physiology and pharmacology, to anesthetic management of specific cardiac surgical procedures, including cardiac percutaneous interventions, management of specific cardiac disease, circulatory support, and organ protection strategies. Written by experienced cardiac anesthesiologists in Europe, USA, Canada and Australia, this book provides an international perspective on the topic with each chapter referring the reader to the relevant key reading.Cardiac Anesthesia and Postoperative Care in the 21st Century is aimed at new consultants in cardiac anesthesia and intensive care, residents, and fellows. It may also be of interest to perfusionists and is a refreshing update for the experienced cardiac anesthesiologist.Table of ContentsPart 1: Basic Concepts.- Anatomy and pathology of the heart.- Cardiovascular physiology.- Cardiovascular pharmacology.- Preoperative assesment and decisions based in test.- Monitoring for cardiac surgery.- Echocardiography.- Angiogram.- Cardiopulmonary bypass.- Pacemaker and other implantable devices.- Hemostasia and coagulation monitoring: Tromboelastogram, ROTEM and platelets mapping.- Part 2: Intraoperative Management.- General principles of anesthesia for adult cardiac surgery.- Fluid management and blood transfusion.- Cardiac electrophysiological interventions.- Myocardial revascularization.- Valvular surgery.- Interventional cardiac procedures.- Aortic arch surgery.- Adult congenital heart disease.- Heart transplantation.- Intra-aortic balloon pump and mechanical circulatory support.- Part 3: Postoperative Care.- Basic concepts of critical care following cardiac surgery.- Issues related to the type of surgery.- Sedation, pain relief and respiratory weaning.- Hemodynamic complications.- Acute kidney injury & management.- Neurocognitive dysfunction and delirium.- Cardiac arrest and post-cardiac arrest management.- Management of mechanical circulatory support.- Management of heart transplant.- Infections and management.

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Book SynopsisThis book provides an unbiased and evidence-based guide to the potential role of interventional pulmonology as an alternative to thoracic surgery. Interventional pulmonology is a new and quickly growing sub-specialty in pulmonary medicine and increasingly more pulmonologists are turning to interventional therapies over the more costly and invasive surgical options. The text thoroughly presents detailed coverage of and diagnostic methods for many diseases and conditions that pulmonologists encounter daily, including: diffuse lung infiltrates, solitary lung nodule, undiagnosed exudative pleural effusion, pneumothorax, hemoptysis, and airway foreign body. Experts then detail treatment options, from both a surgical and interventional perspective, with guidance on: when each procedure is most appropriate, what can be performed by a pulmonologist (with guidelines on how those procedures are done) versus what needs to be referred to a thoracic surgeon or an intervention pulmonologist, and the benefits and disadvantages involved with each option. This is an ideal guide for pulmonologists, trainees, and students to better understand the full scope of possible treatment options for their patients and to make the best informed decision about patient care.Table of ContentsChapter 1. Rigid versus Flexible Bronchoscopy.- Chapter 2. Biopsy for Diffuse Lung Disease: Surgical vs. Cryobiopsy.- Chapter 3. Management of Lung Nodules: A Paradigm Shift.- Chapter 4. Mediastinoscopy: Surgical vs. Medical.- Chapter 5. Airway Foreign Bodies: Rigid vs Flexible Approach.- Chapter 6. Management of Bronchopleural Fistula.- Chapter 7. Management of Acquired Tracheoesophageal Fistula in Adults.- Chapter 8. Lung Volume Reduction: Surgical versus Endobronchial.- Chapter 9. Surgical Versus Medical Management Of Anastomotic Dehiscence.- Chapter 10. Concentric Web Like Stenosis: .- Chapter 11. Hemoptysis.- Chapter 12. Role of Interventional Pulmonology in Miscellaneous Conditions.- Chapter 13. Undiagnosed Exudative Effusion: Thoracoscopy vs. Pleuroscopy.- Chapter 14. Pneumothorax: Large Bore Tubes vs. Pigtail Catheter.- Chapter 15. Pleurodesis: From Thoracic Surgery to Interventional Pulmonology.- Chapter 27. ESD.

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Book SynopsisThis guide walks you through the set-up, supplies, nursing considerations, troubleshooting, and steps to successfully assist during cutting edge interventional Gastroenterological procedures that are being performed to offer patients a safer and more cost effective treatment option. This key resource contributes, as the first of its kind, by helping endoscopic surgical centers to prepare for and train staff in order to offer these new and on the rise procedures to their patients. It goes into detail on each procedure and why a patient would benefit from it. Pictures will be included to demonstrate what the procedure will look like. A detailed step-by-step manual including photos will be put together on each case describing the set-up, pre, intra, and post-procedure care and responsibilities.This step-by-step guide includes a full range of highly advanced procedures that are on the forefront of medicine. It will help Endoscopy nurses and technicians, as well as radiology technicians and endoscopists, who are being trained to perform or assist in these new and complex procedures. Table of ContentsChapter 1: Introduction Chapter 2: GI acronyms Chapter 3: Endoscopic Resection 3.1: Endoscopic Submucosal Dissection Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 3.2: Endoscopic Mucosal Resection Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 3.3: Submucosal Tunneling Endoscopic Resection Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 3.4: Endoscopic Full Thickness Resection Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 4: Endoscopic Myotomy 4.1: ZPOEM Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 4.2: EPOEM Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 4.3: GPOEM Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 5: Anti-Reflex Procedures 5.1: Transoral Incisionless Fundoplication Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 5.2: BARRX Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 6: Endoscopic Retrograde Cholangio-Pancreatography 6.1: Transpapillary ERCP Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 6.2: Endoscopic Ultrasound Guided ERCP Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 6.3: Endoscopic Ultrasound Directed Transgastric ERCP Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 7: Endoscopic Ultrasound Procedures 7.1: Endoscopic Ultrasound guided Liver Biopsy Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 7.2: Celiac Plexus Block Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 7.3: Celiac Plexus Neurolysis Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 7.4: Fine Needle Aspiration/Fine Needle Biopsy Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 7.5: Endoscopic Guided Pancreatic Duct Access Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 7.6: Cyst-Gastrostomy Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 8: Endo-Bariactric Procedures 8.1: Endocopic Sleeve Gastroplasty Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 8.2: Stoma Reduction Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 8.3: Transoral Outlet Reduction Endoscopy Procedure Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up 8.4: Obera Balloon Placement and Removal Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 9: Pancreatic Fluid Collection Procedures Section 1: Necrosectomy Diseases treated and goals of treatment Equipment and supplies needed Set Up Nursing considerations pre, intra and post procedure Patient discharge instructions and follow up Chapter 10: The use of Fluoroscopy during interventional endoscopy Chapter 11: Case Studies

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Book SynopsisThe book discusses the impact of genetics, social determinants of health, the environment, and lifestyle in the burden of cardiometabolic conditions in African American and Hispanic/Latinx populations. It includes fully updated and revised chapters on genetics and CVD risk, epidemiology of cardiovascular health, cardiovascular imaging, dyslipidemias and other emerging risk factors, obesity and metabolic syndrome, heart failure, and genetic variations in CVD. Unique aspects within African American and Hispanic/Latinx populations are explored with suggested appropriate therapeutic interventions. New chapters focus on ASCVD risk assessment, emerging precision medicine concepts, the impact of diabetes, resilience and CVD survival, and lifestyle and dieting considerations. Written by a team of experts, the book examines the degree to which biomedical and scientific literature can clarify the impact of genetic variation and environment on cardiovascular disease. The Second Edition of Cardiovascular Disease in Racial and Ethnic Minority Populations is an essential resource for physicians, residents, fellows, and medical students in cardiology, internal medicine, family medicine, clinical lipidology, and epidemiology.Table of Contents1. Overview and Perspectives: Cardiovascular Disease in Racial/Ethnic Minorities in the era of COVID-19.- 2. Introduction to Precision Medicine: Minority Populations and Cardiovascular Health.- 3. Lipoprotein (a): A Cardiovascular Risk Factor affecting Ethnic Minorities.- 4. Emerging Precision Medicine Concepts and Cardiovascular Health in African Americans and Hispanics.- 5. The Implementation Frontier: Impact on Cardiovascular Health in Racial and Ethnic Minority Populations.- 6. Genomic Approaches to Hypertension.- 7. Heart Failure in African Americans and Hispanic Americans; a persistent and disproportionate burden in under-represented minorities.- 8. Heterogeneity, Nativity, and Disaggregation of Cardiovascular Risk and Outcomes in Hispanic Americans.- 9. Cardiovascular Epidemiology in Hispanics/Latinos: Lessons Learned from HCHS/SOL.- 10. Lessons Learned from the Jackson Heart Study.- 11. Cardiovascular Disease Risk Factors in the Hispanic/Latino Population.- 12. Progress in ASCVD Risk Assessment in African Americans and Hispanic Americans.- 13. CARDIOVASCULAR DISEASE IN MINORITIES - Unique Considerations: Hypertension in African and Hispanic Americans.- 14. Weight Loss, Lifestyle, and Dietary Factors in Cardiovascular Disease in African Americans and Hispanics.- 15. Coronary Calcium Scoring In African American and Hispanic Patients.- 16. Epidemiology of Cardiovascular Disease in African Americans.- 17. Cardiac Amyloid Heart Disease in Racial/Ethnic Minorities: Focus on Transthyretin Amyloid Cardiomyopathy .- 18. Imaging for the Assessment and Management of Cardiovascular Disease in Women and Minority Populations.

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Book SynopsisThis comprehensive book provides detailed practical advice on the diagnosis and surgical management of congenital and acquired conditions in infants and children. Following the great success of the first edition, the new edition has been fully updated to reflect the major developments in the field of the past decade. Advances in prenatal diagnosis, imaging, anaesthesia and intensive care as well as the introduction of new surgical techniques, including minimally invasive surgery and robotic technology that have radically altered surgical conditions are now discussed in the book. In addition new chapters have been added on surgical safety in children, surgical problems of children with disabilities and surgical implications of HIV infection in children among others. This is a superbly structured and richly illustrated guide aimed at trainees, young pediatric surgeons and general surgeons with interest in pediatric surgery. The book also serves as a handy, quick and easy reference for those making decisions in daily practice. Pediatric Surgery, Diagnosis and Management features contributions by leading experts in pediatric surgery and pediatric urology who have unique experience in their respective fields.Table of Contents1 The Epidemiology of Birth Defects.- 2 Prenatal Diagnosis and Fetal Counselling for Surgical Congenital Malformations.- 3 Transport of the Surgical Neonate.- 4 Pre-operative Management and Vascular Access.- 5 Anaesthesia and Analgesia.- 6 Fluid, Electrolyte and Respiratory Management.- 7 Sepsis.- 8 Nutrition.- 9 Access for Enteral Nutrition.- 10 Haematological Problems.- 11 Genetics.- 12 Ethical Considerations in Paediatric Surgery.- 13 Minimally Invasive Surgery in Infants and Children.- 14 Surgical Safety in Children.- 15 Surgical Problems of Children with Disabilities.- 16 Surgical Implications of HIV infection in Children.- Part II Trauma.- 17 Birth Trauma.- 18 Pediatric Thoracic Trauma .- 19 Abdominal and Genitourinary Trauma.- 20 Traumatic Head Injuries.- 21 Paediatric Orthopedic Trauma.- 22 Injuries to the Tendons.- 23 Burns.- 24 Foreign Bodies.- 25 Physical and Sexual Child Abuse.- Part III Head and Neck.- 26 Pierre Robin Sequence.- 27 Choanal Atresia.- 28 Thyroglossal and Branchial Cysts, Sinuses and Fistulas .- 29 Tracheostomy.- Part IV Chest.- 30 Chest Wall Deformities .- 31 Breast Disorders in Children and Adolescents.- 32 Congenital Airway Malformations.- 33 Mediastinal Masses in Children.- 34 Pleural Effusion and Empyema.- 35 Congenital Malformations of the Lung.- 36 Congenital Diaphragmatic Hernia.- 37 Extracorporeal Membrane Oxygenation.- Part V Esophagus .- 38 Esophageal Atresia and Tracheoesophageal Fistula.- 39 Gastroesophageal Reflux Disease.- 40 Achalasia.- 41 Esophageal Perforations and Caustic Injuries in Children.- 42 Esophageal Replacement.- Part VI Gastrointestinal.- 43 Infantile Hypertrophic Pyloric Stenosis.- 44 Gastrostomy and Jejunostomy.- 45 Duodenal Obstruction.- 46 Intestinal Malrotation.- 47 Jejuno-Ileal Atresia.- 48 Meconium Ileus.- 49 Duplications of the Alimentary Tract.- 50 Necrotizing Enterocolitis.- 51 Constipation.- 52 Hirschsprung’s Disease .- 53 Variant Hirschsprung’s Disease.- 54 Anorectal Anomalies.- 55 Appendicitis.- 56 Intussusception.- 57 Omphalomesenteric Duct Remnants.- 58 Hernias.- 59 Short Bowel Syndrome.- 60 Inflammatory bowel disease.- 61 Paediatric Small Bowel Transplantation .- Part VII Liver, Biliary Tract and Pancreas.- 62 Biliary Atresia.- 63 Choledochal Cyst.- 64 Hepatic Cysts and Abscesses.- 65 Portal Hypertension.- 66 Gallbladder Disease.- 67 Pancreatic Disorders.- 68 Splenic Disorders.- 69 Pediatric Liver Transplantation.- Part VIII Anterior Abdominal Wall Defects.- 70 Omphalocele and Gastroschisis.- 71 Bladder Exstrophy.- 72 Cloacal Exstrophy.- 73 Prune Belly Syndrome.- 74 Conjoined Twins.- Part IX Tumors.- 75 Vascular Anomalies .- 76 Congenital Nevi.- 77 Lymphatic Malformations.- 78 Sacrococcygeal Teratoma.- 79 Neuroblastoma.- 80 Wilms’ Tumor.- 81 Soft Tissue Sarcoma.- 82 Hepatic Tumors in Childhood.- 83 Lymphomas.- 84 Ovarian Tumors .- 85 Testis Tumors.- Part X Spina Bifida and Hydrocephalus.- 86 Spina Bifida and Encephalocoele.- 87 Hydrocephalus.- 88 Dermal Sinus and Tethered Cord.- Part XI Genitourinary.- 89 Urinary Tract Infection.- 90 Imaging of the Paediatric Urogenital Tract.- 91 Management of Prenatal Hydronephrosis.- 92 Upper Urinary Tract Obstructions.- 93 Ureteric Duplication Anomalies.- 94 Vesicoureteral Reflux.- 95 Posterior Urethral Valves.- 96 Neuropathic Bladder.- 97 End Stage Renal Disease and Renal Transplantation.- 98 Disorders of Sexual Development.- 99 Cryptorchidism.- 100 Acute Scrotum.- 101 Hypospadias.- 102 Circumcision and Buried Penis.- Part XII Paediatric Gynaecology.- 103 Hydrometrocolpos.- 104 Gynecologic Conditions of Childhood.- Part XIII Long-term Outcomes.- 105 Long-term Outcomes in Pediatric Surgery.

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Book SynopsisThis updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.Table of Contents1. Campylobacter Sophie J. Hedges and Frances M. Colles2. Clostridioides difficile Eliane de Oliveira Ferreira and Gerly Anne de Castro Brito3. CronobacterMarcelo L. L. Brandão and Stephan Forsythe4. Oral and Intestinal Bacteroidetes Marina C. Claros, Zaida C. Claros, Sareh Said Yekta-Michael, and Georg Conrads5. Vibrio choleraeThandavarayan Ramamurthy, Asish K. Mukhopadhyay, Bhabatosh Das, Ranjan K. Nandy, Ankur Mutreja, and G. Balakrish Nair6. Acinetobacter baumanniiDennis Nurjadi and Sébastien Boutin7. EnterococcusLúcia M. Teixeira, Adriana R. Faria, Stephanie S. R. Souza and Vânia Lúcia C. Merquior8. Pseudomonas aeruginosaJunyan Liu, Ruirui Xu, Zerong Lu and Zhenbo Xu9. StaphylococciJoAnn M. McClure and Kunyan Zhang10. BartonellaceaeJoaquim Ruiz, Cláudia Gomes and Maria J.Pons11. BrucellaRoland T. Ashford and Adrian M. Whatmore12. Coxiella burnetiiDimitrios Frangoulidis, Mathias C. Walter, Akinyemi M. Fasemore and Sally J. Cutler

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Book SynopsisThis updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.Table of Contents1. Campylobacter Sophie J. Hedges and Frances M. Colles2. Clostridioides difficile Eliane de Oliveira Ferreira and Gerly Anne de Castro Brito3. CronobacterMarcelo L. L. Brandão and Stephan Forsythe4. Oral and Intestinal Bacteroidetes Marina C. Claros, Zaida C. Claros, Sareh Said Yekta-Michael, and Georg Conrads5. Vibrio choleraeThandavarayan Ramamurthy, Asish K. Mukhopadhyay, Bhabatosh Das, Ranjan K. Nandy, Ankur Mutreja, and G. Balakrish Nair6. Acinetobacter baumanniiDennis Nurjadi and Sébastien Boutin7. EnterococcusLúcia M. Teixeira, Adriana R. Faria, Stephanie S. R. Souza and Vânia Lúcia C. Merquior8. Pseudomonas aeruginosaJunyan Liu, Ruirui Xu, Zerong Lu and Zhenbo Xu9. StaphylococciJoAnn M. McClure and Kunyan Zhang10. BartonellaceaeJoaquim Ruiz, Cláudia Gomes and Maria J.Pons11. BrucellaRoland T. Ashford and Adrian M. Whatmore12. Coxiella burnetiiDimitrios Frangoulidis, Mathias C. Walter, Akinyemi M. Fasemore and Sally J. Cutler

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Book SynopsisDermatology is the science responsible for the study of the skin, mucous membranes (oral and genital) and cutaneous appendages, while dermatopathology focuses on its microscopic study. Although the two fields are closely related, in many cases the identification of dermatological diseases is mainly clinical and depends on the physician’s ability and experience. The purpose of this atlas, which collects over 900 clinical and histological photographs in high resolution, is to illustrate and describe the most frequent skin diseases on the basis of clinical cases. Offering a complete guide to the etiology, epidemiology, clinical features, histologic findings and diagnosis of the main skin diseases divided into three subgroups (inflammatory, infectious, or tumoral), it represents an invaluable resource for all medical students, residents, clinicians, and investigators learning dermatology.Table of ContentsI. INFLAMMATORY SKIN DISEASESChapter 1. Papulosquamous and eczematous dermatoses 1. Dermatitis or eczema a. Contact dermatitis i. Allergic contact dermatitis ii. Irritant contact dermatitis b. Atopic dermatitis c. Aesteatotic dermatitis d. Nummular dermatitis e. Gravitational Dermatitis f. Seborrheic dermatitis g. Palmoplantar vesicular dermatitis i. Ponfólix ii. Chronic vesicle-bullous dermatitis of the hands iii. Hyperkeratotic dermatitis of the hand iv. Ide reaction h. Autosensitization dermatitis i. Herpetic eczema or varicelliform eruption of Kaposi j. Infectious dermatitis k. Chronic simple liquor l. Nodular prurigo m. Plantar Juvenile Dermatosis 2. Psoriasis a. Psoriasis vulgaris or plaques b. Guttate Psoriasis c. Pustular psoriasis i. Located 1. Palmoplantar Pustulosis 2. Continuous acrodermatitis of Hallopau ii. Generalized 1. Acute generalized pustulose (von Zumbusch) 2. Annular pustular d. Inverse psoriasis e. Scalp Psoriasis f. Genital Psoriasis g. Erythrodermic psoriasis h. Nail Psoriasis i. Psoriatic arthropathy j. HIV-associated psoriasis 3. Lichen and lichenoid ​​reactions a. Lichen planus i. Lichen planus pillar ii. Oral lichen planus iii. Actinic lichen planus iv. Lichen planus pigmentosa v. Acute exanthematic flat lichen vi. Lichen inverse plane vii. Genital lichen planus viii. Hypertrophic lichen planus ix. Bullous or pemphigid lichen planus x. Annular lichen planus xi. Linear lichen planus xii. Ungular lichen planus xiii. Ulcerative lichen planus b. Lichenoid reaction c. Fixed pigmented erythema d. Lichen Crisp e. Lichen striatum f. Persistent dyschromic erythema g. Chronic Lichenoid Keratosis Chapter 2. Other Papular, erythematous and scaly diseases1. Pityriasis Lichenoid2. Pityriasis liquenoid and acute varioliform3. Pityriasis, chronic lichenoid4. Pityriasis liquenoid leukcomelandermal5. Pityriasis rubra pilaris6. Pityriasis rosea7. Pityriasis rotunda8. Granular Parakeratosis Chapter 3. Inflammatory diseases of pilose follicle1. Alopecia a. Non-scarring i. Alopecia areata ii. Alopecia universalis iii. Alopecia totalis iv. Patchy alopecia areata v. Diffuse Alopecia areata vi. Ophiasis alopecia vii. Sisaifo or reverse ophiasis alopecia viii. Androgenic Alopecia ix.Telogen effluvium x. Trichotillomania xi. Traction alopecia xii. Temporal triangular alopecia xiii. Lipedematous Alopecia b. Scarring i. Central centrifugal scarring alopecia ii. Lichen planus pilaris 1. Classic type 2. Fibrosing frontal alopecia 3. Graham-Little-Piccardi syndrome iii. Mucinous Alopecia iv. Discoid lupus v. Keloid acne of the neck vi. Decalvating folliculitis vii. Dissecting folliculitis 2. Inflammatory folliculitis a. Pseudofolliculitis of the beard b. Other follicular disorders c. Suppurative Hydradenitis Chapter 4. Inflammatory diseases of the sebaceous and apocrine glands 1. Acne a. Degrees of severity: mild, moderate and severe b. Acne conglobata c. Acne fulminans d. Acne necroticans e. Acne ointment or cosmetic f. Steroid or medication-induced acne g. Hormonal acne h. Neonatal acne i. Childhood acne j. Excoriated acne k. Occupational acne l. Radiation acne2. Rosacea a. Erythematous-telangiectatic rosacea b. Papulopustular rosacea c. Phymatous rosacea d. Ocular rosacea e. Rosaceiform Dermatitis3. Perioral dermatitis Chapter 5. Inflammatory skin diseases induced by drugs1. Drug reactions a. Morbilliform rash b. Erythema multiforme c. Steven-Johnson syndrome d. Toxic epidermal necrolysis e. Drug reaction with eosinophilia and systemic symptoms f. Acute generalized exanthematous pustulosis Chapter 6. Inflammatory diseases of the blood vessels with cutaneous involvement1. Vasculitis a. Small vessel vasculitis i. Leukocytoclastic vasculitis ii. Henoch-Schonlein purple iii. Acute hemorrhagic edema of childhood iv. Erythema elevatum diutinum b. Mixed vasculitis i. Cryoglobulinemia ii. Associated with ANCA antibodies iii. Microscopic polyangiitis iv. Wegener granulomatosis v. Churg-Strauss syndrome c. Secondary i. Septic vasculitis ii. Vasculitis associated with inflammatory disorders (disseminated intravascular coagulation) d. Medium vessel vasculitis i. Polyarteritis nodosa e. Vasculitis of large vessels i. Temporal arteritis ii. Takayasu arteritis Chapter 7. Inflammatory diseases affecting melanocytes 1. Inflammatory diseases that occur with hyperpigmentation a. Post-inflammatory hyperpigmentation b. Persistent dyschromic erythema c. Lichen planus pigmentosa d. Melasma e. Flagellated Erythema f. Confluent and reticulated papillomatosis of Gougerot and Carteaud g. Erythema ab igne 2. Inflammatory diseases that occur with hypopigmentation a. Vitiligo b. Post-inflammatory hypopigmentation c. Lichen sclerosus and atrophic d. Lichen striatum e. Pityriasis alba Chapter 8. Bullous vesicular inflammatory diseases 1. Pemphigus a. Pemphigus vulgaris i. Mucocutaneous ii. Vegetant b. Pemphigus foliaceus i. Seborrheic or classic ii. Fogo type selvagem iii. Senear syndrome - Usher c. Paraneoplastic Pemphigus2. Dermatitis herpetiformis3. Linear IgA dermatosis4. Bullous Pemphigoid5. Scarring pemphigoid6. Pemphigoid gestationis7. Epidermolysis bullosa acquired Chapter 9. Inflammatory skin diseases presented as erythema, urticaria and purpura 1. Urticaria a. Allergic urticaria b. Physical urticaria c. Cold and heat urticaria d. Cholinergic urticaria e. Vasculitic urticaria 2. Figurate erythemas a. Annular Erythema Centrifugal b. Erythema gyratum repens c. Migratory Necrolytic Erythema d. Migratory erythema e. Married Erythema 3. Purples a. Purple Pigments i. Progressive pigmentary dermatosis of Schamberg ii. Majocchi telangiectodes annular purpura iii. Gougerot and Blum pigmentary purpuraica lichenoid dermatitis iv. Lichen aureus v. Pruritic purpura or eczematoid of Doucas and Kapetanakis Chapter 10. Inflammatory connective tissue diseases 1. Cutaneous lupus a. Acute lupus erythematosus b. Subacute lupus erythematosus (SCLE) i. Annular SCLE ii. Papulosquamous/psoriasiform SCLE c. Chronic cutaneous lupus i. Chronic discoid lupus erythematosus 1. Located 2. Disseminated ii. Hypertrophic iii. Lupus panniculitis iv. Lupus Childblain v. Lupus tumidus vi. Bullous lupus d. Other variants i. Rowell syndrome ii. Neonatal Lupus 2. Dermatomyositis3. Scleroderma4. Morphea5. Scleredema6. Recurrent Polychondritis7. Rheumatoid arthritis8. Graft versus host disease Chapter 11. Granulomatous inflammatory diseases1. Sarcoidosis2. Annular granuloma3. Lipoid Necrobiosis4. Giant cell annular elastotic granuloma5. Crohn's disease of the skin Chapter 12. Inflammatory diseases induced by ultraviolet radiation 1. Immunologically mediated dermatoses a. Polymorphic luminic eruption b. Actinic prurigo c. Chronic actinic dermatitis d. Solar urticaria e. Hydroa vacciniform2. Photodermatosis secondary to exogenous agents a. Photocontact dermatitis b. Phototoxic and photoallergic dermatitis 3. Photodermatosis secondary to endogenous agents a. Congenital erythropoietic porphyria b. Erythropoietic Protoporphyria c. Cutaneous porphyria takes d. Pseudoporphyria e. Hepatoerythropoietic porphyria 4. Diseases caused by defects in DNA repair a. Xeroderma pigmentoso b. Trichotiodystrophy 5. Photogravure disorders (present in each respective section) a. Lupus erythematosus b. Dermatomyositis c. Rosacea d. Atopic dermatitis e. Seborrheic dermatitis Chapter 13. Neutrophilic and eosinophilic inflammatory diseases 1. Neutrophilic Infiltrates a. Acute febrile neutrophilic dermatosis (Sweet syndrome) b. Pyoderma gangrenosum c. Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) d. Behcet's disease e. Neutrophilic dermatosis of the back of the hands f. Ecrine Neutrophilic Hydradenitis g. Rheumatoid Neutrophilic Dermatitis 2. Eosinophilic Infiltrates a. Facial granuloma b. Eosinophilic pustular folliculitis c. Eosinophilic cellulitis d. Eosinophilic Fasciitis Chapter 14. Inflammatory diseases of subcutaneous cell tissue 1. Lobular Panniculitis a. Indurated Bazin Erythema or Nodular Vasculitis b. Pancreatic panniculitis c. Scleredema neonatorum d. Fat necrosis of the newborn e. Post-steroid panniculitis f. Lupus panniculitis g. Panniculitis due to dermatomyositis h. Lipodystrophic Panniculitis i. Cold panniculitis j. Sclerosing Lipogranuloma k. Paniculitis from injected substances l. Lipodermatosclerosis2. Septal panniculitis a. Paniculitis due to alpha 1 antitrypsin deficiency b. Erythema nodosum II. INFECTIOUS SKIN DISEASES Chapter 15. Bacterial infections 1. Staphylococcal and streptococcal infections a. Impetigo b. Ectima c. Erysipelas d. Cellulitis e. Acute lymphangitis f. Necrotizing Fasciitis g. Folliculitis, boil, anthrax h. Acute paronychia2. Staphylococcal and streptococcal toxin syndromes a. Scalded skin syndrome b. Toxic Shock Syndrome c. Toxic Streptococcal Shock Syndrome d. Scarlet fever e. Erysipeloid f. Corinebacterial Infections g. Erythrasma h. Keratolysis punctata3. Gram-negative infections a. Gangrenous Ectima b. Infections caused by Bartonella c. Disease cat scratch d. Bacillary Angiomatosis e. Bacteria previously classified as fungi f. Actinomycosis g. Nocardiosis Chapter 16. Mycobacterial Infections 1. Leprosy a. Cutaneous tuberculosis b. Tubercle chancre c. Bazin indurated erythema d. Escrofuloderma e. Lichen scrofulosorum f. Lupus vulgaris2. Acute disseminated miliary tuberculosis3. Papulonecrotic tuberculosis4. Tuberculosis verrucous complexion5. Non-tuberculous mycobacteria Chapter 17. Fungal infections 1. Superficial mycoses a. Dermatophytosis or ringworm i. Tinea capitis ii. Tinea Faciei iii. Ringworm of the beard iv. Tinea corporis v. Inguinal ringworm vi. Tinea Pedis vii. Tinea Incognita b. Cutaneous Candidiasis i. Oral and perioral candidiasis ii. Pseudomembranous iii. Perleche (angular cheilitis) iv. Atrophic oral candidiasis v. Hypertrophic oral candidiasis vi. Genital candidiasis vii. Candidiasic Intertrigo viii. Candidatic Perionixix c. Onychomycosis d. Pityriasis versicolor e. Black ringworm2. Deep mycoses a. Chromomycosis b. Mycetoma c. Sporotrichosis d. Lobomycosis 3. Systemic mycoses a. Blastomycosis b. Coccidiodomycosis c. Histplasmosis d. Paracoccidiodomycosis Chapter 18. Virus infections 1. Enterovirus a. Hand-foot-mouth disease b. Herpangina c. Pseudoangiomatosis eruptive 2. Herpesvirus (VHH) a. VHH 1 AND 2: Herpes simplex virus (HSV) types 1 and 2 i. Herpetic gingivostomatitis ii. Genital herpes iii. Herpetic eczema iv. Herpetic Panadizo v. Herpes gladiatorum vi. Herpetic folliculitis vii. Herpes simplex hypertrophic b. VHH 3: Varicella zoster virus i. Chickenpox ii. Congenital chickenpox iii. Herpes zoster c. VHH 4: epstein-barr virus i. Hairy leukoplakia ii. Ulcers of lipschütz iii. Hydroa vacciniforme d. VHH 5: Cytomegalovirus e. VHH 6: Herpesvirus type 6 i. Exanthem Subitum f. VHH 7: Herpes virus type 7i. Pityriasis rosea g. VHH 8: Herpesvirus type 8 i. Kaposi's sarcoma 3. Papillomavirus a. Vulgar warts b. Flat warts c. Accumulated condyloma d. Bowenoid Papulosis e. Heck disease 4. Poxvirus a. Molluscum contagiosum b. Orf nodule c. Milkman's Node5. Other virus diseases a. Chikungunya b. Infectious erythema c. Unilateral laterothoracic rash d. Roseola e. Rubella f. Measles g. Gianotti-crosti syndrome Chapter 19. Sexually transmitted diseases 1. Syphilis2. Gonorrhea3. Chancroid4. Venereal lymphogranuloma5. Inguinal granuloma Chapter 20. Infections by parasites 1. Protozoa a. Leishmaniasis2. Helminths a. Cutaneous Migrans Larva b. Filariasis3. Infestations a. Scabiosis b. Pediculosis c. Tungiasis d. Cutaneous myiasis III. NEOPLASTIC SKIN DISEASES Chapter 21. Benign neoplasms 1. Benign epidermal tumors and proliferations a. Seborrheic keratosis b. Lichenoid Keratosis c. Estucokeratosis d. Poroqueratosis e. Papular nigrans dermatosis f. Verruciform Acrokeratosis g. Cutaneous horn h. Clear cell acanthoma i. Acanthoma Acanthoma j. Epidermolytic acanthoma k. Large cell acanthoma l. Inverted follicular keratosis m. Epidermal nevus n. Linear Verrucous Epidermal Nevus o. Flegel disease (hyperkeratosis lenticularis perstans) p. Comedogenic Nevus q. Acanthosis nigricans r. Confluent and cross-linked papillomatosis s. Clear cell papulosis 2. Cysts with stratified squamous epithelium a. Epidermoid cyst b. Winer's dilated pore and pillar sheath cliff c. Millium Cyst d. Triquilemal cyst e. Proliferating epidermoid cyst f. Cyst hair vellus g. Steatocistoma h. Keratocysts i. Follicular Hybrid Cyst j. Dermoid cyst k. Pre-auricular cyst l. Pilonidal cyst Chapter 22. Skin adnexal neoplasms 1. Hair follicle nevus2. Trichofolliculoma3. Sebaceous Nevus4. Tricoepitelioma / tricoblastoma5. Desmoplastic trichoepithelioma6. Pilomatricoma7. Pilmatrical carcinoma8. Triquilemoma9. Triquilemal Carcinoma10. Tumor of the follicular infundibulum11. Tricoadenoma12. Proliferating pillar tumor13. Sebaceous gland hyperplasite14. Sebaceous adenoma-sebaceous epithelioma, sebaceoma15. Sebaceous carcinoma16. Syringoma17. Poroma18. Hydradenoma19. Apocrine adenoma20. Papilliferous Syringocystodenoma21. Spiroadenoma22. Cylindroma23. Porocarcinoma24. Ecrine Nevus25. Sirigofibroadenoma26. Papillary adenoma and adenocarcinoma Chapter 23. Muscle, adipose tissue and cartilaginous neoplasms 1. Leiomyoma2. Leiomyosarcoma3. Smooth muscle hamartoma4. Lipoma5. Angiolipoma6. Hibernoma7. Superficial lipomatous nevus8. Lipoblastoma9. Liposarcoma10. Chondrome Chapter 24. Vascular malformations 1. Capillaries: a. Klippel syndrome - Trenaunay b. Porto wine stain2. Arterial: Angiohistiocytoma a. Telangiectasias b. Cutist congenital telangiectatic marmorata c. Angiokeratomas3. Venous: a. Venous Cephalic Malformation b. Glomus-venous4. Lymphatic: hemangiolinphangioma5. Other vascular malformations: a. Anemic nevus b. Venous lake c. Cherry anigoma d. Telangiectatic granuloma 6. Infantile hemangioma Chapter 25. Fibrous and fibrohystiocytic proliferations of skin and tendons 1. Dermatofibromas2. Angiofibromas3. Loose fibroma4. Superficial fibromatosis: Juvenile plantar fibromatosis: Plantar fibromatosis Ledderhose disease5. Acral fibrokeratoma6. Superficial acral fibromxoma7. Pleomorphic skin fibroma8. Giant cell tumors of the tendon sheath9. Tendon sheath fibroma10. Nodular fasciitis11. Connective tissue nevus12. Children's digital fibroma13. Childhood Myofibromatosis14. Aponeurotic calcifying fibroma15. Atypical fibroxanthoma16. Dermatofibrosarcoma protuberans17. Giant cell fibroblastoma Chapter 26. Congenital melanocytic nevus and acquired1. Congenital melanocytic nevus2. Acquired melanocytic nevus: union, compound, intradermal3. Ungular matrix melanocytic nevus4. Spilus nevus5. Miescher's Nevus6. Spitz nevus7. Meyerson Nevus8. Sutton nevus or halo nevus9. Becker's Nevus10. Dysplastic or Clark's Nevus11. Blue nevus Chapter 27. Neural and neuroendocrine neoplasms1. Neurofibroma2 Neurothecoma3. Schwanoma4. Granular cell tumor5. Perineuroma6. Tumor of the malignant peripheral nerve sheath7. Merkel cell carcinoma8. Nasal glioma Chapter 28. Disorders of cells of langerháns and macrophages1. Langerhans cell histiocytosis2. Histiocytosis of non-Langerhans cells3. Xanthomas Chapter 29. Malignant neoplasms1. Actinic Keratosis2. Adenoescamous carcinoma3. Basal cell carcinoma4. Basescamosal carcinoma5. Keratoacanthoma6. Bowen's disease7. Queyrat Erythroplasia8. Squamous cell carcinoma9. Bowen's disease10. Mastocytosis11. Melanoma12. Skin metastasis13. Paget's disease 14. T-cell Lymphoma a. Lymphomatoid papulosis b. Leukemia / T-cell lymphoma c. Mycosis fungoides d. Primary gamma / delta cutaneous T-cell lymphoma e. CD8 positive aggressive epidermotropic cytotoxic T cell lymphoma f. Nasal extraganglionic T / NK cell lymphoma g. Paniculitis like T-cell lymphoma15. B-cell Lymphoma a. Primary cutaneous B-cell lymphoma of the marginal zone b. Primary cutaneous central follicle lymphoma c. Diffuse giant B-cell cutaneous lymphoma type leg d. Intravascular diffuse giant B-cell lymphoma e. B cell precursor lymphoblastic leukemia / lymphoma Chapter 30. Other lymphoproliferative disorders 1. Plasmocytoid dendritic cell neoplasia2. Jessner lymphocytic infiltrate3. Lymphocytoma cutis4. Extramedullary hematopoiesis5. Leukemia complexion6. Hodgkin's disease7. Lymphomatoid granulomatosis

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Book SynopsisThis book covers the scope of cranial nerve monitoring of all cranial nerves that are of practical importance in head, neck, and thyroid surgery. It discussed enhanced patient outcomes in a wide array of surgical procedures in the head and neck that require the maintenance of complex regional functions by protecting cranial nerve integrity.Organized into four parts, the book begins with Part I offering historical perspectives on the subject while simultaneously reviewing various basic and advanced electrophysiology. Part II thoroughly reviews the extra-temporal bone facial nerve (CN VII), Glossopharyngeal Nerve (CN IX), Vagal/Recurrent Laryngeal Nerve (CN X), Spinal Accessory Nerve (CN XI), and Hypoglossal Nerve (CN XII). Subsequent chapters in Part III provide a complete and applied understanding of the neurophysiological principles that facilitate the surgeon’s ability to monitor any nerve and intraoperative neural stimulation and nerve monitoring. The book presents various techniques as the standard of care to provide optimal neural detection, understand the neural functional real-time status during surgery and optimize specific surgical outcomes such as thyroid surgical outcomes. Closing chapters offer essential conversations regarding ethical considerations in nerve monitoring and medical malpractice.Filling a gap in the literature, Intraoperative Cranial Nerve Monitoring in Otolaryngology: Head and Neck Surgery provides a single source for surgeons who wish to optimize their outcomes in patient care and accelerate their learning curve to the level of more experienced surgeons.Table of ContentsPart I: Nerve Monitoring Principles.- Historical Perspective on Nerve Monitoring during Head and Neck Surgery.- Basic and Advanced Electrophysiology.- Anesthesia Considerations and Set-up.- Neural Injury Mechanisms.- Education.- Part II: Vagus/Recurrent Laryngeal Nerve Monitoring.- Rationale and Indications for Vagus/Recurrent Laryngeal Nerve Monitoring.- methods for Vagus/Recurrent Nerve Monitoring.- Monitoring of the Superior Laryngeal Nerve.- Continuous Intraoperative Neuromonitoring (CIONM).- Emerging Trends for Vagus/Recurrent Laryngeal Nerve Monitoring.- Troubleshooting System Integrity.- Managing Loss of Signal.- Incorporating Never Monitoring into the Intraoperative Management of Invasive Thyroid Cancer.- Nerve Monitoring in Remote Access Thyroid Surgery.- Nerve Monitoring in Parathyroid Surgery.- Part III: Facial Nerve, Glossopharyngeal Nerve, Hypoglossal Nerve Monitoring.- Facial Nerve Monitoring, Extratemporal Facial Nerve.- Spinal Accessory Nerve Monitoring.- Glossopharyngeal Nerve and Hypoglosssal Nerve Monitoring.- Part IV: Miscellaneous Nerve Monitoring Considerations.- Documentation and Reimbursement.- Ethical Considerations in Nerve Monitoring.- Nerve Monitoring and Medical Malpractice.

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Book SynopsisThis book provides a concise yet comprehensive resource on Diabetic Kidney Disease. Similar to the previous edition, the book reviews the most up-to-date research on diabetic nephropathy, the current understanding of its pathophysiology, renal structural alterations and clinical features, and summarizes recent evidence-based clinical treatment modalities for the prevention and management of diabetic kidney disease. General clinical aspects are also covered, as well as an overview to the novel approaches being designed by leading researchers in the field.A convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, Diabetes and Kidney Disease, 2e is also a handy resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.Table of Contents Historical Background of Diabetic Kidney Disease Review of Clinical Practice Guidelines I. Natural Course, Pathogenesis, Morphology and Genetics Diabetic Kidney Disease: Scope of the Problem Natural Course Pathogenesis: Hemodynamic alterations Pathogenesis: Structural Changes in the Kidneys in Type 1 and Type 2 Diabetes Diabetes in Children and Adolescents II. Clinical Presentation and Associated Conditions Screening, Early Diagnosis, Genetic markers and Predictors of Progression Atypical Presentations Albuminuria and Proteinuria Hypertension and Diabetes Obesity and Metabolic Syndrome Anemia and Diabetes Carvdiovascular Disease and Diabetes Dyslipidemia and Diabetes Bone Disease and Diabetes Diabetic Retinopathy Pregnancy and Diabetes Kidney Transplantation and Kidney Pancreas Transplantation Diabetic Kidney Disease and Covid-19 III. Treatment and Prognosis Glycemic Control Computerized Clinical Decision Support Antihypertensive therapies Metformin Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors Glucagon-like Peptide-1 Receptor Agonists (GLP1-RA) Dipeptidyl Peptidase-4 (DPP4) Inhibitors Novel Treatments and the Future of DKD: What is on the Horizon? Putting it All Together: Practical Approach to the Patient with Diabetic Kidney Disease

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Book SynopsisThis book chronicles the life and accomplishments of Dorothy Hansine Andersen, a pioneering American pathologist and pediatrician who was the first person to define, diagnose, and treat cystic fibrosis.Divided into three parts, the book begins by detailing Anderson’s early life, including being orphaned as an adolescent, her college career, and her laborious start in the medical field. Part II then examines Andersen’s role in defining the new disease “cystic fibrosis of the pancreas” and her career of active engagement in various clinical pursuits and research, both in pathology and pediatrics. Chapters in this section also discuss the numerous attempts made by others to minimize Andersen’s work through gender bias and the Matilda Effect. The book concludes by reviewing the foundations laid for CF, Andersen’s legacy, and her terminal illness. Featuring an engaging narrative style, Dorothy Hansine Andersen is a historically relevant, invaluable text for anyone interested in the life of Dorothy Anderson and the nascence of cystic fibrosis diagnoses.Table of ContentsTable of Contents:Introduction Part I: Life before Babies Hospital Chapter 1: A beginning Chapter 2: Orphaned Chapter 3: College and medical school Chapter 4: False start Chapter 5: A reboot Part II: Babies Hospital during the McIntosh Era Chapter 6: Historical perspectives Chapter 7: Synergy Chapter 8: Andy’s abandoned farm Chapter 9: Scoring the first goal Chapter 10: CF firsts Chapter 11: “To Dr. Andersen who has pulled me through many a tough year” Chapter 12: McIntosh, pediatric pathology, and Columbia University Chapter 13: CF sweat and the Matilda Effect Chapter 14: Glycogen storage diseases Chapter 15: Celiac disease Chapter 16: Randomized, controlled trials Chapter 17: Babies Hospital siblings Chapter 18: A last decade of CF research Chapter 19: Pediatric heart diseases Part III: Beyond Babies Hospital and the McIntosh Era Chapter 20: Time to enjoy the view Chapter 21: A foundation and a club for CF Chapter 22: The end of an era Chapter 23: Cancer Afterword

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Book SynopsisThis textbook addresses the growing international need for a practical manual that teaches physicians how to apply cold atmospheric pressure plasma (CAP) in the day‐to‐day provision of patient healthcare.The book introduces readers to the concept of CAP, how it works, and how safe it is, before describing several diseases and other medical indications for its application. The book subsequently provides guidelines for daily clinical practice, e.g. for treating chronic wounds, decontaminating infected skin lesions, and rendering multi-resistant bacteria inert, as well as a detailed overview of plasma devices. In closing, it addresses organizational aspects, which are essential to cultivating and maintaining quality standards in the application of cold medical plasma.This textbook offers a unique educational resource and provides relevant information on plasma medicine as an emerging multidisciplinary discipline. Practitioners will appreciate this integrated, comprehensive guide, which is also suitable for advanced students of medicine and dentistry, and for nurses serving on plasma-assisted medical teams.Table of ContentsIntroduction.- Leap innovation in basic research for patient benefit.-Concept.- What´s this, cold physical plasma?.-How does cold plasma work in medicine?.-Landmarks to differentiate between reliable and questionable devices for application in plasma medicine.-How safe is clinical plasma medicine?.-The Patient's View at Basic Principles.-The Patient´s View at Basic Clinical Principles.-Treatment Tailored to Indications.-Cold plasma treatment for chronic wounds.- Cold plasma treatment for acute wounds.-Cold plasma treatment for infected wounds.-Cold plasma treatment for contaminated cancer ulcerations.-Cold plasma treatment of surgical site infections and surgical sites at risk.-Cold plasma treatment for an artificial fistula at risk.-Cold plasma treatment and aesthetic medicine .-Cold plasma treatment for dental aesthetics.-Devices.- Basic principles and future developments in cold plasma therapy.-kINPen MED®.-PlasmaDerm® FLEX and Dress.- Steriplas® and PlasmaTact®.-Plasma care®.-Organization.- Who belongs to a good cold plasma practice team?.-How to assure good clinical practice in cold plasma therapy?.-What are the requirements of a cold plasma medicine clinic?

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Book SynopsisThis book by leading international experts provides an evidence-based approach to electrical stimulation of the upper airway, beginning with patient selection, implant techniques, trouble shootings, patient pathways, titrations during daytime and sleep as also new innovative techniques such as stimulation of the ansa cervicalis and the phrenic nerve. Key Features: · Superbly illustrated schematic drawings and full-colored photographs; · Step-by-step description of surgical concepts and techniques on all of the market available systems (Inspire, Nyxoah, LivaNova, Remede); · Complete online media library with videos on the surgical procedures; · New surgical steps presented for well established procedures (e.g. 2-incicions technique); · Discussion of outcomes, success rates, risks, and potential troubleshooting’s, where evidenced-based data are not available, expert opinion is provided. Upper Airway Stimulation in Obstructive Sleep Apnea will be welcomed by residents, fellows, and board-certified surgeons in otorhinolaryngology and head and neck surgery.Table of Contents1. The burden of obstructive sleep apnea: A clarion call to act. 2. Treatment options in Sleep Apnea. 3. Effect of Hypoglossal Nerve Stimulation on Cardiovascular Outcomes.4. History of electrical stimulation in sleep apnea. 5. Embryology of the Hypoglossal nerve. 6. Considerations of Facial Skeletal Morphology to Optimize Upper Airway Stimulation. 7. The Hypoglossal nerve and its anatomical variability. 8. Patient Selection, including drug induced sleep endoscopy. 9. Overview of different HN-Stimulation systems.10. Inspire:11. Livanova: 12. Nyxoah: 13. Upper Airway Stimulation Therapy: an evaluation of outcomes. 14. Surgical techniques in upper airway stimulation.15. Treatment pathway.16. Trouble shooting. 17. Hypoglossal Nerve Stimulator in Pediatric Down Syndrome Patients. 18. Daytime polysomnography in upper airway stimulation. 19. Phrenic Nerve Stimulation in central apnea. 20. Stabilizing sleep through closed-loop acoustic stimulation; implications for obstructive sleep apnea treatment. 21. Special cases. 22. Ansa cervicalis stimulation for obstructive sleep apnea.23. Future Perspective of electrical stimulation in sleep apnea.

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Book SynopsisThis comprehensive source on the pathogenic origins of neuropathic pain covers the detailed molecular bases of the currently known neuropathies as classified by their pathogenic origins.Filling a critical need, this book fills the need for a resource on a syndrome that demands improved understanding by clinicians and researchers alike so that treatment options for patients are not categorically limited to a pill or a needle. If the clinician understands the origins of a patients' neuropathic pain, they can work cooperatively toward improving it with tailored therapies that don't create societal diseconomies and that ultimately are effective in helping patients.The book presents in detail the molecular bases of some currently known neuropathies by their pathogenetic origins, allowing clinicians to tailor more specific and more effective treatment regimens for their patients. For basic researchers, this book is a general resource to better direct research on neuropathy-specific molecular mechanisms. The improved understanding of the pathogenesis of neuropathic pain can then be used to develop more specific and more effective manipulations of these pathways.Table of Contents

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