Cardiovascular medicine Books

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Table of ContentsPart I: Overview 1. Making Cardiomyocytes from Pluripotent Stem Cells Peter Karaginius and Yoshinori Yoshida Part II: Generation of Pluripotent Stem Cell-Derived Cardiomyocytes and Cardiac Tissues 2. A method for Large-Scale Cardiac Differentiation, Purification, and Cardiac Spheroid Production of Human Induced Pluripotent Stem Cells Yuika Morita, Shugo Tohyama, Jun Fujita, and Keiichi Fukuda 3. Large-scale Differentiation of Stem Cell-Derived Cardiomyocytes by Stirring-Type Suspension Culture Nagako Sougawa, Shigeru Miyagawa, and Yoshiki Sawa 4. Efficient Method to Dissociate Induced Pluripotent Stem Cell-derived Cardiomyocyte Aggregates into Single Cells Emiko Ito, Shigeru Miyagawa, Yoshinori Yoshida, and Yoshiki Sawa 5. Isolation of Cardiomyocytes Derived from Human Pluripotent Stem Cells using miRNA switches Kenji Miki, Hirohide Saito, and Yoshinori Yoshida 6. Fabrication of Cardiac Constructs using bio-3D Printer Kenichi Arai, Daiki Murata, Shoko Takao, and Koichi Nakayama 7. Fabrication of Thick and Anisotropic Cardiac Tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium Junjun Li, Li Liu, Itsunari Minami, Shigeru Miyagawa, and Yoshiki Sawa 8. Construction of Three-Dimensional Cardiac Tissues Using Layer by Layer Method Maki Takeda, Shigeru Miyagawa, Mitsuru Akashi, and Yoshiki Sawa 9. Generation of Cylindrical Engineered Cardiac Tissues from human iPS Cell-derived Cardiovascular Cell Lineages Hidetoshi Masumoto Part III: Physiological Mesurements using Pluripotent Stem Cell-Derived Cardiomyocytes 10. Protocol for Morphological and Functional Phenotype Analysis of hiPS-derived Cardiomyocytes Jun LI and Jong-Kook LEE 11. Application of FluoVolt Membrane Potential Dye for Induced Pluripotent Stem Cell-derived Cardiac Single Cells and Monolayers Differentiated via Embryoid Bodies Tadashi Takaki and Yoshinori Yoshida 12. Multi-Electrode Array Assays Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Daisuke Yoshinaga, Yimin Wuriyanghai, and Takeru Makiyama 13. Electrophysiological Analysis of hiPSC-derived Cardiomyocytes Using a Patch-Clamp Technique Yuta Yamamoto, Sayako Hirose, Yimin Wuriyanghai, Daisuke Yoshinaga, and Takeru Makiyama 14. Characterization of Ventricular and Atrial Cardiomyocyte Subtypes from Human Induced Pluripotent Stem Cells Misato Koakutsu, Tadashi Takaki, Kenji Miki, and Yoshinori Yoshida 15. Assessment of Contractility in Human iPS Cell-Derived Cardiomyocytes Using Motion Vector Analysis Yasunari Kanda, Ayano Satsuka, Sayo Hayashi, Mihoko Hagiwara-Nagasawa, and Atsushi Sugiyama 16. Contractile Force Measurement of Engineered Cardiac Tissues Derived from Human iPS Cells Daisuke Sasaki, Katsuhisa Matsuura, and Tatsuya Shimizu 17. A Method for Contraction Force Measurement of iPSC Derived Engineered Cardiac Tissues Yuya Fujiwara, Kohei Deguchi, Kenji Miki, Tomoyuki Nishimoto, and Yoshinori Yoshida Part IV: Transcriptome and Bioinfomatics Analysis 18. Single-cardiomyocyte RNA Sequencing to Dissect the Molecular Pathophysiology of the Heart Manami Kotoh, Seitaro Nomura, Shintaro Yamada,Hiroyuki Aburatani, and Issei Komuro 19. RNA-sequencing Analysis of Differentially Expressed Genes in Human iPSC-derived Cardiomyocytes Chikako Okubo, Megumi Narita, Takuya Yamamoto, and Yoshinori Yoshida 20. Analysis of Transcriptional Profiling of Chamber-specific Human Cardiac Myocytes Derived from Pluripotent Stem Cells Antonio Lucena-Cacace and Yoshinori Yoshida Part V: Gene Editing and CRISPR Technology for Pluripotent Stem Cells 21. Genome Editing in Human Induced Pluripotent Stem Cells (hiPSCs) Shuichiro Higo, Shungo Hikoso, Shigeru Miyagawa, and Yasushi Sakata 22. Generation of Efficient Knock-in Mouse and Human Pluripotent Stem Cells Using CRISPR-Cas9 Tatsuya Anzai, Hiromasa Hara, Chanthra Nawin, Taketaro Sadahiro, Masaki Ieda, Yutaka Hanazono, and Hideki Uosaki 23. CRISPRi/a Screening with Human iPSCs Masataka Nishiga, Lei S. Qi, and Joseph C. Wu Part VI: Transplantation of Pluripotent Stem Cell-Derived Cardiomyocytes 24. Transplantation of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes in a Mouse Myocardial Infarction Model Takeshi Hatani and Yoshinori Yoshida 25. Transplantation of Pluripotent Stem Cell-derived Cardiomyocytes into a Myocardial Infarction Model of Cynomolgus Monkey Hideki Kobayashi, Hajime Ichimura, Noburou Ohashi, and Yuji Shiba

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Book SynopsisNow that state of the art equipment can be carried in ambulances, prehospital emergency staff are able to perform an ECG soon after arrival on scene, enabling the EMS provider to gather important diagnostic information that can not only guide prehospital therapy but also direct hospital-based treatment.Table of ContentsList of Contributors ix Foreword xi Preface xiii Section 1 The ECG in Prehospital Patient Care 1 1 Clinical applications of the electrocardiogram (ECG) 3 Robert C. Schutt William J. Brady and Steven H. Mitchell 2 Clinical impact of the electrocardiogram (ECG) 7 Robert C. Schutt William J. Brady and Steven H. Mitchell 3 Interpretation of the electrocardiogram – single-, multi-, and 12-lead analysis 12 Robert C. Reiser Robert C. Schutt and William J. Brady 4 Variants of the normal, lead misplacement, and electrocardiographic artifact encountered in clinical practice 17 Robert C. Reiser Robert C. Schutt and William J. Brady Section 2 Cardiac Rhythms and Cardiac Dysrhythmias 23 5 Cardiac rhythms with normal rates 25 Korin B. Hudson and William J. Brady 6 Narrow QRS complex tachycardia 29 Courtney B. Saunders and Jeffrey D. Ferguson 7 Wide QRS complex tachycardia 37 Michael Levy and Francis X. Nolan Jr 8 Bradycardia 44 Korin B. Hudson J. Aidan Boswick and William J. Brady 9 Atrioventricular conduction block 50 Steven H. Mitchell Korin B. Hudson and William J. Brady 10 Intraventricular conduction block: bundle branch block and other conduction abnormalities 54 Steven H. Mitchell Richard B. Utarnachitt and William J. Brady 11 Atrial and ventricular ectopic beats 62 Jeffrey D. Ferguson Michael Levy J. Aidan Boswick and William J. Brady Section 3 Acute Coronary Syndrome and the 12-Lead ECG 67 12 Ischemic heart disease: anatomic and physiologic considerations 69 Peter Pollak Peter Monteleone Kelly Williamson David Carlberg and William J. Brady 13 Historical development of the prehospital electrocardiogram (ECG) 76 Erik Iszkula David Carlberg and William J. Brady 14 Electrocardiographic findings in acute coronary syndrome 79 Peter Monteleone Peter Pollak David Carlberg and William J. Brady Section 4 Special Populations High-Risk Presentation Scenarios and Advanced Electrocardiographic Techniques 95 15 The electrocardiogram in the pediatric patient 97 Robert Rutherford Robin Naples and William J. Brady 16 The electrocardiogram in the poisoned patient 104 Steven H. Mitchell Christopher P. Holstege and William J. Brady 17 The electrocardiogram in hyperkalemia 112 Steven H. Mitchell and William J. Brady 18 Life-threatening electrocardiographic patterns 117 Steven H. Mitchell Richard B. Utarnachitt and William J. Brady 19 The electrocardiogram in patients with implanted devices 122 Amita Sudhir and William J. Brady 20 Electrocardiographic tools in prehospital care 127 Robin Naples Alvin Wang and William J. Brady 21 Wolff-Parkinson-White syndrome 134 William J. Brady 22 Cardiac arrest rhythms 138 Amita Sudhir and William J. Brady Section 5 Electrocardiographic Differential Diagnosis of Common ECG Presentations 145 23 Electrocardiographic differential diagnosis of narrow complex tachycardia 147 Megan Starling and William J. Brady 24 Electrocardiographic differential diagnosis of wide complex tachycardia 152 Amita Sudhir and William J. Brady 25 Electrocardiographic differential diagnosis of bradyarrhythmia 161 Megan Starling and William J. Brady 26 Electrocardiographic differential diagnosis of ST segment elevation 165 Megan Starling and William J. Brady 27 Electrocardiographic differential diagnosis of ST segment depression 176 Amita Sudhir and William J. Brady 28 Electrocardiographic differential diagnosis of T wave abnormalities: the prominent T wave and T wave inversions 183 Amita Sudhir and William J. Brady Index 195

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Book SynopsisA definitive, comprehensive text on the technological developments and clinical applications of this critical subject matter. Written for the entire heart surgery team, this volume covers the physiology of cardiopulmonary bypass, mechanics and components of the heart-lung machine, the conduct of cardiopulmonary bypass in cardiac surgery, non-cardiac applications of cardiopulmonary bypass, and mechanical assistance of the failing heart and lung. The authors also give special consideration to such areas as blood conservation in cardiac surgery, religions objections to blood transfusions, medical-legal aspects and cardiopulmonary bypass, as well as warm blood cardioplegia and normothermic cardiopulmonary bypass.Trade Review"The editor is to be congratulated for a text that reads smoothly without significant repetition or variations in style...The book has excellent references with valuable illustrations and drawings. This reviewer highly recommends this book for reference and review." Anesthesia and AnalgesiaTable of ContentsI. The History of Cardiopulmonary Bypass.- 1. Cardiopulmonary Bypass: The Historical Foundation, the Future Promise.- II. Physiology of Cardiopulmonary Bypass.- 2. The Myocardium: Physiology and Protection During Cardiac Surgery and Cardiopulmonary Bypass.- 3. Hypothermia, Cardiac Surgery, and Cardiopulmonary Bypass.- 4. Pharmacokinetics and Pharmacodynamics During Cardiac Surgery and Cardiopulmonary Bypass.- 5. Hemostasis and Cardiopulmonary Bypass.- 6. The Central Nervous System: Responses to Cardiopulmonary Bypass.- 7. The Respiratory, Renal, and Hepatic Systems: Effects of Cardiac Surgery and Cardiopulmonary Bypass.- 8. The Immunologic System: Perturbations Following Cardiopulmonary Bypass and the Problem of Infection in the Cardiac Surgery Patient.- 9. The Endocrine System: Effects of Cardiopulmonary Bypass.- III. Mechanics and Components of the Heart-Lung Machine.- 10. Oxygenators for Extracorporeal Circulation.- 11. Mechanical Pumps for Extracorporeal Circulation.- 12. Conduits and Filters for Extracorporeal Circulation.- 13. Assembling and Monitoring the Extracorporeal Circuit.- 14. Heat Exchange in Extracorporeal Systems.- IV. Conduct of Cardiopulmonary Bypass for Cardiac Surgery.- 15. Aortoatriocaval Cannulation for Cardiopulmonary Bypass.- 16. Initiation and Maintenance of Cardiopulmonary Bypass.- 17. Discontinuation of Cardiopulmonary Bypass.- 18. Safety and Management of Perturbations During Cardiopulmonary Bypass.- V(a). Cardiopulmonary Bypass in Special Patient Populations.- Complete Cardiopulmonary Bypass.- 19. Pediatric Cardiopulmonary Bypass.- 20. Thoracic Aortic Surgery and Cardiopulmonary Bypass.- 21. Intracranial Surgery with Cardiopulmonary Bypass.- 22. Emergency Coronary Artery Bypass and Cardiopulmonary Bypass.- 23. Chest Trauma and Emergency Cardiopulmonary Bypass.- 24. Pregnancy and Cardiopulmonary Bypass.- V(b). Cardiopulmonary Bypass in Special Patient Populations.- Partial Cardiopulmonary Bypass.- 25. Cardiopulmonary Bypass-Supported Angioplasty.- 26. Closed Chest Bypass for Liver Transplantation.- VI. Mechanical Assist of the Failing Heart and Lung.- 27. Ventricular Assist Devices.- 28. Intraaortic Balloon Pump Counterpulsation.- 29. Extracorporeal Membrane Oxygenation for Severe Cardiorespiratory Failure.- 30. The Intravascular Oxygenator, IVOX®: Augmentation of Blood-Gas Transfer.- VII. Special Considerations in Cardiopulmonary Bypass.- 31. Blood Conservation in Cardiac Surgery.- 32. Religious Objections to Blood Transfusion.- 33. Medical-Legal Aspects of Cardiopulmonary Bypass.- 34. Warm-Blood Cardioplegia and Normothermic Cardiopulmonary Bypass.

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Book SynopsisBrings together the most recent research and current issues facing medical professionals and patients in intensive cardiovascular care to provide the necessary tools and resources for improved health and medical care. It includes chapters on safety, ethics, and specific surgical techniques.

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