Books by Leon V Berhardt

Book SynopsisAdvances in Medicine and Biology. Volume 157 opens with a study wherein the authors use guinea pig airway smooth muscle to demonstrate that testosterone blocks L type voltage dependent Ca2+ channels. Furthermore, in vivo experiments with sensitized guinea pigs show that bronchospasm induced by antigenic challenge was abolished by testosterone and its 5α and 5β-dihydrotestosterone metabolites. Following this, the authors evaluate the structural features of skeletal muscles in children and adults with various pathologies of the musculoskeletal system based on ultrasonography, considering periods of natural growth and involutive changes. An overview of the current state of research on fluoxetine for the treatment of anxiety alone or combined with depression is provided, along with its possible side effects. Also provided is scientific information is regarding the neurobiological bases of depression and therapeutic effects of fluoxetine during the different periods of menopause. This information could be useful in pharmacological strategies for the treatment of depression occurring in the menopausal women. One chapter focuses on how improved direct access to the liver protected inside the rib cage can be obtained in laparoscopic liver resection using its specific "Caudal approach", decreasing the risk of refractory ascites and liver failure, especially in hepatocellular carcinoma patients with chronic liver diseases. The nucleolus is packed with proteins involved in ribosome function and biogenesis, as well as other proteins involved in cell-cycle regulation, senescence and stress response. However, little is known about the molecular mechanism of protein turnover in the nucleolus. As such, the authors discuss the nucleolus-localized protein degradation pathway, which is essential to ribosome production and cell-cycle progression. The concluding chapter focuses on the dye Congo red, which is used as a stain in microscopy to detect an abnormal material called amyloid. Amyloid consists of misfolded proteins that form fibrils which bind molecules of Congo red and orientate the molecules parallel to the long axis of the fibrils.Table of ContentsPreface; Industrial Application of Microbial Amylases; Fungal Lipases Production by Solid-State Fermentation: An Opportunity for Increasing Process Profitability; Application of Lipase in Non-Conventional Media Based Catalysis; Production and Applications of Microbial Tannase; Xylanase: An Industrially Important Enzyme; Microbial Alkaline Proteases: Production and Application in the Leather Industry; The Beneficial Role of Microbial Catalyst for Sustainable Environment; Microbial Enzymes: The Types and Roles in the Bio-Control of Fungal Phytopathogens; Enzymes and Their Vital Role in the Food Industry; Potential Application of Enzymes of Lactic Acid Bacteria in the Food Industry; The Potential Application of Microbial Catalyst in Food Biotechnology; Functional, Structural, and Thermodynamic Characteristics of Enzymes from Deep-Sea Microorganisms; Solving the Structure of Amidase-03; An Overview about Our Understanding of Protein Activity, Specificity, Structure and Function; Index.

Read more less

Book SynopsisThis volume discusses the merits and demerits of currently available conventional cholera vaccine delivery systems and therapies, and the potential role of novel nanomaterials-based delivery approaches for the management of cholera. Cholera, the watery diarrhea caused by Vibrio cholerae, is a major public health issue in the developing world. V. cholerae is a gram negative, facultative anaerobic, aquatic bacterium with single polar flagellum and is a member of γ subdivision of the family Proteobacteriaceae. Following this, the structures and functions of human helicases and the 5-upstream regions of the encoding genes are classified for further investigation. Genetic studies have revealed that mutations in some of these genes are associated with certain human diseases, including Xeroderma Pigmentosum, Cockayne Syndrome and Werner Syndrome. The authors describe a practical exercise where the construction of a pharmacophore model is interpreted with the aid of 2-D structures, while the final model is used in a virtual screening to identify potentially active kinase inhibitors. The use of freely available software and web servers makes this exercise a useful and easily implementable resource for almost any undergraduate student. This compilation also addresses how folate intake during pregnancy is essential for adequate fetoplacental development and for the health of the baby. Neural tube defects are a preventable cause of mortality and morbidity, and the prevalence of neural tube defects has significantly decreased worldwide after the fortification of folic acid. Subsequently, the authors describe recent findings in the storage and supply site, localization, and imaging of high-density lipoprotein in human coronary arteries. In an effort to achieve less invasive surgery justified by better outcomes, lower hospital costs, patient recovery time and cosmetic results, the authors also review innovative surgical techniques such as minilaparoscopy, single incision laparoscopic surgery, natural orifice transluminal surgery and others that are being employed or expected to be the future. The concluding chapter describes several cases where Mycoplasma have led to the electronic contamination of prestigious public data stores.Table of ContentsPreface; Potential Treatment Strategies for the Management of Cholera: A Review; An Insight into the Physiological Properties and Virulence of Vibrio cholera; Transcription Regulatory Systems of the Human Helicases; Pharmacophore Perception by Pattern Recognition: Model Contruction, Validation and Application to Virtual Screening in a Practical Exercise; Effects of Folate on the Health of the Fetus and Neonate; Storage and Supply Site, Localization, and Fluorescent Angioscopic Imaging of High-Density Lipoprotein in Human Coronary Plaques; Advances in Cholecystectomy: A Review; Mycoplasma ∪Homo Sapiens: Contamination in E-Science; Index.

Read more less

Book SynopsisVolume 162 opens with an assessment of the modern available data, as well as the results from the authors' own research, on the neurotropic effects of amino acid L-arginine. The effects of L-arginine and some arginine-containing oligopeptides on pain and pain-induced behavior in rats are examined. Depending on their binding to activate specific receptors, antagonists have selective functions. As such, this compilation details their specificity, mode of interactions and their usefulness and drawbacks for humans. Next, a review on how CD14 interacts with different ligands is discussed, particularly focusing on how CD14 consequently transduces the signaling to induce some relevant diseases. The authors also review some trends in the treatment of anxiety with natural compounds and transition metal-catalyzed couplings for the synthesis of new drugs with anxiolytic properties. Natural products have been widely used in the treatment of anxiety disorders and as a source of bioactive heterocyclic compounds. Methods for improving the perception and attitude of health workers towards generic drugs are proposed, such as putting forward generic drugs as one of the learning topics in college curricula, and conducting scientific discussions and conferences on generic drugs through professional organizations. The penultimate study comprehensively reviews the clinicopathological features of lipoblastomas and emphasizes the importance of accurate diagnosis and the differentiation of lipoblastomas from other histologically similar lipomatous neoplasms. The closing study proposes that the relaxant effects of flavone may be due to the inhibition of enzyme activities and intracellular Ca2+ of the trachealis after increasing these two cyclic nucleotides.Table of ContentsPreface; Neurotropic Effects of Amino Acid L-Arginine and Arginine-Containing Oligopeptides; Agonists: Types and Activity; CD14: Interactions and Functions; An Approach to the Natural Anxiolytics and Catalytic Functionalization; How to Improve the Perception and Attitude of Health Workers towards Generic Drugs; Lipoblastoma; Flavone via Phosphodiesterase Inhibition Leftward Shifted the Log Concentration-Relaxation Curves of Forskolin and Nitroprusside in Isolated Guinea-Pig Trachea; Index.

Read more less

Book SynopsisAdvances in Medicine and Biology. Volume 163 begins by discussing lipidomics, a newly emerging field of biomedical research that uses a mass spectrometry-based tool for the quantitative and qualitative analysis of complex lipids in the biological system. Following this, the authors analyze basic aspects of the cellular processes involved in olfactory signal transduction, focusing on the neurogenic processes of neuronal stem cells from the olfactory neuroepithelium. Recent information from several experimental studies is presented highlighting the application of CCl4 as an inducer of pathophysiological changes in key organs of the body. The preparation, advantages and multi-functionality of nano emulsions is reviewed in the context of their potential applications in targeted drug delivery. The existing preclinical and clinical studies carried out with sacubitril-valsartan (and other drugs with similar pharmacological mechanisms) in heart failure and hypertensive patients are described. The authors go on to explore monoclonal antibodies targeting multiple myeloma, a plasma cell neoplasia accounting for 10% of hemopoietic neoplasias. The closing study examines the various approaches for mitral valve surgery, comparing and contrasting the benefits and drawbacks of each.Table of ContentsFor more information, please visit our website at:https://novapublishers.com/shop/advances-in-medicine-and-biology-volume-163/

Read more less

Book SynopsisAdvances in Medicine and Biology. Volume 164 begins by proposing that first-line chemotherapy of metastatic colorectal cancer consensus molecular subtypes appears to be a prognostic factor that is able to provide information about growth rate. The authors go on to review the current and future applications of bioartificial grafts and conduits in the bridging of peripheral nerve defects. Ginsenoside Rb1 and phosphoramidon are studied in the zebrafish model of diabetic retinopathy, a progressive proliferative and non-proliferative disorder of retina with alterations of the blood-retinal barrier. Basic knowledge on the events from follicle development to implantation crucial to achieve successful conception as well as contraception is presented, describing the mechanism of contraceptive action of Chhaya. Hydroxydaunorubicin, also known as doxorubicin, a metabolite of Streptomyces peucetius and a prominent family member of anthracycline antibiotics is studied. The authors also review the possible mechanisms by which doxorubicin provokes concomitant side effects and clinical disorders, as well as the damage-assaying biochemical markers and the metabolites in these conditions. Updated data with a systematic search through the largest medical information databases is used to assess the therapeutic and preventive role in urinary incontinence of pelvic floor rehabilitation in pregnancy and postpartum. In closing, recent studies on the host and lactic acid bacteria as well as probiotic interactions in terms of molecular and cellular mechanisms of action via signaling pathways, apoptosis, and heat shock proteins are reviewed.

Read more less

Book SynopsisVolume 165 first presents promising information about the essential goal of effective and safe medication for target patients with the appropriate genotypes. The authors explore the diverse causes of neonatal leukemoid reaction in premature infants proposed by Hill and Duncan in 1941, such as intrauterine infection and maternal steroid administration. This compilation also explores hjypoxia-inducible factor-1, a key gene regulator for cellular adaptation to hypoxia which leads to a transcriptional response under physiological as well as pathological conditions. From a historical perspective, Wilms' tumor treatment is assessed, focusing on the different approaches of the two main groups, the Children's Oncology Group and the International Society of Paediatric Oncology. The genetics and genomics of Plasmodium, which include multiple parameters and factors affecting disease transmission, are assessed in an effort to enhance our knowledge about the disease. Following this, whole slide imaging or virtual microscopy is used for the quantitative evaluation of liver biopsy specimens of patients with chronic hepatitis. The closing study examines data which reveals changes in the functioning of the ceruloplasmin/transferrin system, decreasing the content of toxic ions of Fe2+ in the plasma of patients with Parkinson's disease. These changes are a pathogenetically significant factor of Parkinson's disease at all stages.

Read more less

Book SynopsisIn this compilation, the authors review the available evidence of the benefits of benfotiamine administration, paying particular attention to patients with type 2 diabetes mellitus and diabetic peripheral neuropathy, cardiac autonomic neuropathy and gastrointestinal neuropathy. An overview of cyclic AMP response element binding protein's structure and functions is provided, in addition to a review of its molecular mechanisms and role in disease processes, including neural diseases, diabetes and cancer. Based on bibliographic references and studies carried out by the authors, this work also assesses the problem of modular total hip prostheses, regarded as a closed loop biotribosystem. The best available evidence in the field of dental rehabilitation is discussed, with the goal of constructing a reliable base for the approach of new investigations. In closing, the authors present the synthesis methods and pharmacological properties of triazole-derived heterocyclic systems. Triazoles are an important class of heterocyclic compounds that are five-membered aromatic azole ring with three nitrogen and two carbon atoms.Table of ContentsPreface; Recent Advances in the Treatment of Neuropathies in Type 2 Diabetes Mellitus Patients: Focus on Benfotiamine (Review and Own Data); CREB: Structure, Functions, and Role in Disease; A Suggestive Qualitative Review of the Tribological Implications of Total Hip Prostheses Modularization; Variations of Masticatory Efficiency in Dentate Patients and Those Wearing Implant Overdentures, Fixed-Detachable Hybrid Prostheses, and Complete Dentures With and Without Denture Adhesive; Thiazolidinone-Related Heterocyclic Compounds as Potential Therapeutic Agents; Synthesis and Pharmacological Activities of Triazole Derivatives; Index.

Read more less

Book SynopsisThis compilation opens with a review of the current knowledge regarding the impact of endocrine disruptors on human health, as well as the mechanisms contributing to it. The authors emphasize the evidence of aquaporin modulation by hypoxia and erythropoietin, as these water channels are increasingly valued as potential biomarkers of disease, as well as pharmacological targets for the treatment of brain and renal injuries, cardiovascular disorders and cancer. Later, the safety and tolerability of adalimumab demonstrated in pivotal phase III clinical trials is examined, along with long-term follow up data from open-label extensions and the ESPRIT registry. Adalimumab for the treatment of ankylosing spondylitis and peripheral spondyloarthritis is also discussed. The authors go on to study the types, causes, effect and problems related to polycystic ovary syndrome. The closing study deals with the relationship between reactive oxygen species and male fertility, providing some futuristic approaches for better research in the field.

Read more less

Book SynopsisThe role of CYP2D6 in the pharmacokinetic and/or pharmacodynamic differences in opiates and opioid consumers is discussed, as well as the associated genetic implications and consequences in the scope of clinical and forensic toxicology. Studies conducted on postmortem pharmacogenetic cases are investigated, and the benefits of CYP2D6 profiling during forensic investigations are discussed. The authors discuss recent advances in the split crest technique, underlining the importance of soft tissue management, especially at the level of the upper jaw where bone augmentation may be sufficient to install dental implants, but soft tissue grafting is necessary to achieve adequate aesthetic results. Hyaluronan or hyaluronic acid, an extracellular polysaccharide usually found associated with the cell surfaces, is explored. The subsequent article deals with the various stages, pathology, etiology and recent treatments associated with rheumatoid arthritis. Additionally, a comparative survey of current cardiovascular imaging practices/methodologies is provided, including magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasonography. The closing study highlights the fundamentals of pharmaceutical gels, their morphological and rheological properties, formulation considerations, and analytical and stability aspects.

Read more less

Book SynopsisAdvances in Medicine and Biology. Volume 169 begins with a focus on psoriasis, a chronic inflammatory skin disease that displays autoimmune traits with strong genetic predispositions. Often, psoriasis is associated with significant physical or psychosocial burden, poor quality of life and significant long-lasting impairments. Following this, the authors discuss matrix metalloproteinases, multi-domain proteins with activities regulated by tissue inhibitors of metalloproteinases. Cyptorchidism, a congenital pathological condition characterized by the failure of testes to descend to the scrotum, is also discussed. Exposure to environmental toxicants, pesticides, pharmaceuticals and drugs of abuse can lead to altered reproductive parameters like histopathology of reproductive organs, sperm morphology, altered hormone level, oxidative stress and inflammation. As such, the subsequent study deals with different toxicants and their routes of exposure. The role that endometriosis, polycystic ovary syndrome, endometrial polyps and uterine fibroids may play in female infertility is examined. The authors present three cases of twin pregnancy with complete hydatidiform mole and a coexisting normal fetus. The course of pregnancy, ultrasound findings, and histological and immunohistochemical characteristics are described along with the p57 status. In the closing study, the mode of action, indications, contraindications, side effects, drug-drug interactions and pharmacokinetic parameters of secnidazole are discussed in detail.

Read more less

Book SynopsisAdvances in Medicine and Biology. Volume 170 begins by presenting the latest evidence that Alzheimer's disease-related proteins and their genes play a role in post-ischemic brain damage, and that an ischemic episode is an essential and leading provider of Alzheimer's disease development. The authors go on to review the pathophysiology, symptoms, epidemiology, analysis, and treatment of Alzheimer's disease. Important issues when appraising and interpreting studies on fertility awareness methods used for avoiding pregnancy are described, and correct clinical applications of fertility awareness methods for contraception are also discussed. The basic molecular pathology of human cancers is discussed, as well as rising technologies for tumour characterization and the role of molecular profiling in identifying potential targets for individualised treatment. Additionally, an overview of the various modalities for assessing the liver functional reserve in patients undergoing hepatic resection is provided. Lastly, data on the linearization of somatic growth plots in humans and rats is discussed, showing the existence of at least two ontogenetic transitions: juvenile and pubertal.Table of ContentsPreface; Brain Ischemia as a Bridge to Alzheimers Disease; An Overview of Alzheimers Disease; Fertility Awareness Methods and Contraception: Evidence and Clinical Application; Molecular Pathology of Cancer; Liver Function: An Overview; Linearized Non-monotonic Growth Plots Reveal Ontogenetic Transitions Probably Related to the Principal Transformation from Development to Aging; Index.

Read more less

Book SynopsisThis compilation begins by examining the use of propofol for end of life sedation. As the use of this medication in end-of-life care is uncommon, providers may lack practical experience and resources that are specific to this specialized application. Following this, the authors describe the role of sperm DNA integrity in miscarriage, including a review of the available DNA fragmentation assays and treatment options for high levels of DNA fragmentation. Mental health literacy is reviewed, particularly focusing on possible reasons for the current illiteracy and aiming to determine how literacy be achieved in the mental health field. The evidence demonstrating that seasonal influenza infection is an additional risk factor for acute vascular events, including both acute myocardial infarction and ischemic stroke, is explored. Some challenging cases of total hip arthroplasty are reviewed in light of recent literature, including: multiple failed hip arthroplasties in a young noncompliant patient, dysplastic hips with insufficient bone stock, acetabular wall defect in an elderly patient, unavoidable intra-operative complications and septic hip complication in childhood. The transversus abdominis plane block, a block in which a local anaesthetic drug is deposited in the plane between two abdominal wall muscles, is surveyed as a promising modality for analgesia. The authors discuss molecular epidemiology in the field of infectious diseases, which points to the detection of genetic polymorphisms based on measures of genetic heterogeneity among strains of microorganisms of clinical importance. In the closing review, a comprehensive look at the current state of knowledge with regard to molecular networks of halotolerance in cyanobacteria is provided, focusing on important components functioning in ion homeostasis, de novo synthesis of novel compatible solutes, and the adaptation of intracellular molecular events by salt-responsible components.

Read more less

Book SynopsisVolume 172 first discusses the advances in formulations for dermal delivery of alpha-tocopherol. Alpha-tocopherol is the major biologically active homolog of vitamin E in human skin, especially the epidermis, and acts as an important antioxidant. Next, the three components that collaboratively engage in the blood epididymal barrier are reviewed, and their individual contribution to protection of the spermatozoa from the immune system is discussed. This compilation includes information regarding the logistics and personal experiences of two separate National Aeronautics and Space Administration (NASA) space missions, Rodent Research-IV and Cell Science-02, as well as for preliminary experiment verification tests and launch simulation testing. Additionally, the authors delve into an International Space Station National Lab Principal investigator''s experiences while working with NASA on the aforementioned space biology research projects. The influence of ancestry in pharmacogenomics is discussed from the past to the present, focusing on ethnic distinct populations and how specific mutations observed in these populations may play an important role. The authors explore the way Aeromonas hydrophila has demonstrated involvement in the nutrient cycles of the aquatic environment and may be considered a potential biotechnological tool in biofactory of nanoparticles, bioleaching or bioremediation. The concluding study focuses on rotavirus A, a major pathogen associated with gastroenteritis of children aged under five which contributes to childhood morbidity and mortality in developing countries.

Read more less

Book SynopsisStress conditions stimulate the accumulation of antioxidants in photosynthetic organisms, but can also restrict their normal growth rate. As such, this compilation opens with a two-stage technique for microalgae cultivation that may resolve this problem by separating biomass accumulation and stimulation biosynthesis of Î-tocopherol. Following this, the authors describe the structural and enzymatic properties of plant PM-H+-ATPases, their regulation and physiological roles. A selective review of the experimental literature concerning the effects of early life stress in brain development is provided, with emphasis on the role of inflammatory responses, the gut microbiome mediating brain and behavioral changes relevant to mental health disorders. The impact of urgency on the temporal organization of prehospital interventions is assessed, analyzing the impact of the characteristics of the patient, the paramedic and the working environment on the sequence and duration of prehospital interventions. The authors shed light on prehospital work by examining how paramedics experience encounters with persons in crisis through a qualitative research approach. Additionally, they aim to assess the association between estimated pulse wave velocity and metabolic biomarkers in patients with albuminuria through a subsequent study. The concluding study focuses on thoroughly revealing the various hallmarks of apoptosis and the overall mechanism which connects these hallmarks.

Read more less

Book SynopsisVolume 174 first provides a systematic review of the synthetic route and biological activities associated with 1,2,4-oxadiazole, 1,2,5-oxadiazole and 1,3,4-oxadiazole derivatives. The authors discuss recent advances in understanding the enantioselective separation and biological activities of the naturally occurring chiral compounds of essential oils. Subsequently, orthobiologics are discussed in the context of their potential in the management of early osteoarthritis, particularly focusing on the treatment of cartilage injuries. Another study aims to improve our understanding of the pathological mechanisms of choroidal neovascularization and approaches how to address the issue in central serous chorioretinopathy. An overview of the lignocellulolytic enzymes secreted by A. fumigatus during biomass conversion is provided, focusing on the quantitative expression of cellulolytic, hemicellulolytic, and ligninolytic enzymes and their synergetic mechanism during biomass degradation. The closing report reviews the current literature on metabolic syndrome, exploring the mechanisms proposed to better understand the role of environmental, genetic, and epigenetic aspects in the pathogenesis of this condition.

Read more less

Book SynopsisIn the first chapter, the authors intend to carry on a critical review of the different methods and approaches to determine the biomechanical output of joint stiffness, designated as dynamic joint stiffness by the authors. The second chapter summarizes several preceding articles on invasive procedures applied with questionable clinical indications in the former Soviet Union. The aim of the third chapter is to give information about how to use tacrolimus, in which type of glomerulonephritis and what are the treatment results, especially remission and relapse rates. In the fourth chapter, a ten-week experiment was conducted to assess the effect of supplementing Synechococcus sp. and Synechocystis sp. on the growth performance, haematology, serology and disease resistance in Oreochromis mossambicus. In the final chapter, discussions of the special properties of endothelial cells and their ability to generate the thrombotic microangiopathic syndrome and ARDS are undertaken based upon current knowledge of the capillary endothelial cells. Attempts are made to address the current pathophysiology of non-idiopathic thrombotic microangiopathy.Table of ContentsPreface; Dynamic Joint Stiffness: A Critical Review; Invasive Procedures with Unproven Efficiency; Glomerulonephritis Treatment and the Era of Tacrolimus; Cyanobacteria as a Dietary Supplement for Oreochromis mossambicus (Peters, 1852); Non-Idiopathic Thrombotic Microangiopathy in Viral Pneumonias and Paraquat Poisoning. Is the Alveolus the Seat of the Primary Event; Index.

Read more less

Book SynopsisThis compilation comprises 8 chapters, each of which details a recent advancement in medicine and biology. Chapter 1 describes innate immune responses and their role in controlling infections, including the relationship between innate and adaptive immune responses during infections. Chapter 2 focuses on the structural characteristics of transforming growth factor beta (TGF-Î) and its diverse biological activities in cancer signalling pathways and presents current information about the role of TGF-Î in cancer cell signalling. Chapter 3 summarises several preceding articles on invasive procedures applied with questionable clinical indications in the former Soviet Union. Chapter 4 provides information about the physical properties, isomerism, synthesis and reactions of thiadiazole, with emphasis placed on the current studies of various syntheses of thiadiazole compounds and their important biological properties. Chapter 5 evaluates the antifungal activity of the leaf ethanolic extract of Persea americana, popularly known as avocado, and its modulatory potential in association with fluconazole to verify its action on Candida micromorphology as well as its chemical characterization. Chapter 6 explores the step-by-step role of TGF-Î during the process of wound healing. Chapter 7 describes hypophosphatasemia, a rare pathophysiological condition that causes various diseases, and includes new information about hypophosphatasemia that has assisted with the diagnosis of Kikuchi Fujimoto disease and can help to predict the outcome of cardiac surgery and septic shock. Finally, Chapter 8 summarizes the evolution of digital holography, including the latest results on visualizing and distinguishing different types of blood cells.

Read more less

Book SynopsisThis compilation comprises 6 chapters, each detailing a recent advancement in medicine and biology. Chapter 1 deals with tuberculosis (TB), describing current knowledge of disease pathogenesis, epidemiology of TB and drug-resistant TB, evolution and molecular mechanisms of drug resistance, fitness compensatory mechanisms and laboratory methods for the diagnosis of susceptible and drug-resistant TB. Chapter 2 details the use of B cell-targeted therapy for treatment of autoimmune and chronic inflammatory diseases. Chapter 3 concerns peptic ulcer disease and the various therapeutic approaches used to treat ulcers or lesions in the gastrointestinal tract. Chapter 4 discusses the efficacity of in vitro cultures of Astragalus for biomass and secondary metabolite production. Chapter 5 describes the B lymphocyte activation factor (BAFF), a potent cell-survival factor expressed in many hematopoietic cells. Finally, Chapter 6 presents a review of the literature to determine the relationship between non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and hepatocellular carcinoma to establish a guideline for monitoring patients.

Read more less

Book SynopsisThis monograph includes seven chapters that describe recent advances in medicine and biology. Chapter One discusses glutathione transferases (GSTs) from helminth parasites in the host-parasite interaction and candidates for vaccine development targeting parasitic GSTs. Chapter Two reviews the pharmacological and therapeutic effects of onion and its constituents in allergic and immunologic disorders. Chapter Three discusses state-of-the-art knowledge of apolipoprotein E (ApoE) polymorphism to demonstrate its wide biological properties and its effects on how medical conditions can be managed. Chapter Four introduces the antiviral and immunomodulatory effects of macrolides and the associated mechanisms in the human airway and lung cells. Chapter Five evaluates the role of several genes that are likely to be involved in diabetic neuropathy by employing transcriptome analysis. Chapter Six details diagnosis, risk factors, and treatment of nephrotic syndrome, the frequent cause of chronic kidney diseases observed in children and adults. Finally, Chapter Seven describes the characteristics of the Michigan Cancer Foundation-7 (MCF-7) cell line and its significant role in the anticancer research paradigm.

Read more less

Book SynopsisThis book includes five chapters, each representing a recent advancement in medicine and biology. Chapter One discusses future aspects of sports medicine and their applications. Chapter Two deals with clinical visual impairment in the elderly population resulting from neurodegenerative diseases such as Alzheimer's disease. Chapter Three reviews recent promising alternatives to protamine, which is currently used as a heparin antagonist but can cause dangerous side effects. Chapter Four describes the factors responsible for the development of diseases such as SARS, MERS, and Ebola. Finally, Chapter Five discusses the future applications of Drosophila melanogaster in neurobehavioural studies.Table of ContentsPreface; Future Aspects of Sports Medicine; Clinical Visual Impairment in Neurodegenerative Disease; Heparin Antagonists: Alternatives to Protamine; Immunological Responses with Reference to Antibody towards Viruses and Re-Emerging Viruses; Drosophila melanogaster as a Model Organism for Neurobehavioural Studies; Index.

Read more less

Book SynopsisThis edited volume includes eight chapters, each of which describe recent advances in medicine and biology. Chapter One discusses dietary recommendations and beneficial compounds, such as vitamin D, omega-3 fatty acids, antioxidants, and phytochemicals to aid the management of abnormal lipid metabolism in postmenopausal women. Chapter Two discusses the role of viral infection and features from the host that take part in the development of hemophagocytic lymphohistiocytosis (HLH). Chapter Three analyses the effects of caffeine and coffee consumption on airways and lung function, particularly in the case of asthma. Chapter Four describes the use of natural and herbal drugs in the treatment of hepatitis B. Chapter Five presents the results of a genetic survey for carbapenem-resistant Klebsiella pneumoniae (CRKP). Chapter Six describes the treatment of degenerative lumbar spinal stenosis using soft interspinous process device. Chapter Seven reviews the efficacy of tonsillectomy for rheumatic diseases. Finally, Chapter Eight summarises the available literature concerning graft pre-soaking in anterior cruciate ligament reconstructions as a method of reducing the likelihood of post-operative infections, which can lead to septic arthritis.Table of ContentsPreface; What Is Menopause?; Viral Infection and Hemophagocityc Lymphohistiocitosis; Coffee and Caffeine Respiratory Health Benefits: A Review; An Update on Natural or Herbal Drugs against Hepatitis B Virus; Molecular Epidemiology of Klebsiella pneumoniae Producing KPC-17 and NDM-1 Carbapenemases in Southern Taiwan; The Role of Soft Interspinous Process Device Coupled Decompression for the Treatment of Degenerative Lumbar Spinal Stenosis; Tonsillectomy for Rheumatic Diseases; To Soak or Not to Soak? Reducing the Risk of Infection after Anterior Cruciate Ligament Reconstruction with Vancomycin Pre-Soaking; Index.

Read more less

Book SynopsisThis monograph contains six chapters, each of which provides details about recent advancements in the field of medicine and biology. Chapter One describes the discovery of AZQ, a drug specifically designed to shut off genes that cause brain cancer. Chapter Two analyses the structure, stability, adaptation to extreme environments and the catalytic mechanism of α-helical membrane proteins. Chapter Three provides an up-to-date overview of artificial intelligence (AI) in assisted reproductive treatment (ART) clinics and explores how AI learns and develops a dataset to provide clinical guidance. Chapter Four consists of a study focused on the etiopathogenesis of primary open angle glaucoma using laboratory mice. Chapter Five presents and comments on the current evidence regarding diagnostics in patients with metastatic breast cancer based on circulating tumour cells (CTCs). Lastly, Chapter Six reviews the pathogenetic and clinical features of inner ear involvement in congenital cytomegalovirus (cCMV), the most frequent non-genetic cause of permanent sensorineural hearing loss in childhood.Table of ContentsPreface; The Impact of Sequencing Human Genome on Genomic Medicine and the Discovery of AZQ (US Patent 4,146,622) Specifically Designed to Shut Off Genes that Cause Brain Cancer; CU(I)-Transport ATPases. Molecular Architecture, Catalysis and Adaptation to Extreme Environments; The AI Doctor Will See You Now: Are Doctors and Embryologists No Longer Indispensable in Assisted Reproductive Treatment (ART)?; Search for New Theories of Etiopathogenesis of Primary Open Angle Glaucoma: Features of Level of Intraocular Pressure and Number of Retinal Ganglion Cells in Conditions of Genetic Defect of Different Subtypes of A1-Adrenoreceptors; Circulating Tumor Cells in Metastatic Breast Cancer: Ready for Clinical Practice?; Inner Ear Involvement in Congenital Cytomegalovirus Infection; Index.

Read more less

Book SynopsisThis edited volume presents seven chapters detailing recent advancements in the fields of medicine and biology. Chapter One describes the regularities of abzyme production in patients with autoimmune diseases as well as in experimental mice. Chapter Two reviews the partners that assist polytopic membrane proteins in their way to acquiring their final structure. Chapter Three presents an approach for the development of an efficient biological sensor for the detection of biochemicals in large scales. Chapter Four shows the different flavin-based fluorescent proteins and fatty-acid-binding proteins and the advantages and disadvantages of using these anaerobic fluorescent proteins for real-time imaging in complex systems versus aerobic fluorescent proteins. Chapter Five discusses the main benefits of exercise for cirrhotic patients and current exercise prescription guidelines for this population. Chapter Six concerns the role thiamine deficiency plays in causing paediatric lactic acidosis. Finally, Chapter Seven discusses the mechanism of wound healing involving stem cells in IIIa burns and proposes using the state of NC1 conformations as an objective indicator of epidermal restoration and the topology of solenoid chromosome construction as an indicator of dermis restoration.Table of ContentsPreface; The Extreme Diversity of Autoantibodies and Abzymes against Different Antigens in Patients with Various Autoimmune Diseases; The Many Partners of Polytopic Membrane Proteins on their Way to Folding; An Approach for Uric Acid Detection with Cerium Sulphide @ Carbon Nanocomposites; Anaerobic Fluorescent Proteins: Advantages and Applications; Exercise as a Treatment Strategy for Cirrhotic Patients; Thiamine Deficiency as a Cause of Pediatric Lactic Acidosis; Non-invasive Molecular Monitoring of Burn Healing IIIa In Vivo; Index.

Read more less

Book SynopsisThis edited volume contains six chapters that each describe recent advancements in medicine and biology. Chapter One summarizes recent discoveries regarding the immunomodulatory effects of vitamin D3 on human health with an emphasis on the interplay of transcription factors and reviews the most recent recommendations based on new clinical evidence for vitamin D3 dosages for the prevention and treatment of COVID-19. Chapter Two focuses on idiopathic membranous nephropathy, the most common cause of nephrotic syndrome in adults who do not suffer from diabetes mellitus. Chapter Three details the emerging worldwide prevalence of myopathies, their evolving diagnostic parameters, and the newer therapeutic modalities. Chapter Four includes a review of medroxyprogesterone, which is a type of progestin that is used as a long-lasting injectable contraceptive and for the treatment of hormone-dependent tumours. Chapter Five describes synovial fluid, which lubricates and cushions joints during motion, and the effects of visco-supplements on the function of synovial fluid. Lastly, Chapter Six introduces the properties of dopamine acrylamide and discusses its application potential in detail.Table of ContentsPreface; Vitamin D in Transcriptional Regulation of Immune Response and Inflammation; Clinical Picture and Management of Nephrotic Syndrome Due to Membranous Nephropathy; Myopathy: Diagnosis, Prevalence and Treatment; Review on Medroxyprogesterone Acetate and Its Detection; Synovial Fluid: Lubrication Mechanism and Viscosupplements; Development of Bio-Inspired Monomer, Dopamine Acrylamide; Index.

Read more less

Book SynopsisThis edited volume contains seven chapters, each detailing recent advancements in medicine and biology. Chapter One presents an overview of drug-related problems in pediatrics. Chapter Two evaluates the role that Maytenus ilicifolia can play in the treatment of melanoma skin cancer. Chapter Three presents a review of biosensors for lipopolysaccharides and assays for studies of lipopolysaccharide binding interactions. Chapter Four presents a literature review of treatment options for carpal tunnel syndrome. Chapter Five describes the application of metabolomics, a science that quantifies and qualifies metabolites in an organism, in bio-medical research. Chapter Six presents the results of a systematic screening that was performed to identify macromolecules that are able to induce accumulation of ascitic fluid in rodents. Finally, Chapter Seven describes a study wherein the method of gravitational mass spectroscopy was used to study the long-range order in an ensemble of atomic nuclei clusters in chicken egg yolk before and after adsorption by beet sugar on the chromosomes.Table of ContentsPreface; An Overview of Drug-Related Problems in Pediatrics; Maytenus ilicifolia as Complementary Alternative for the Treatment of Melanoma Skin Cancer; Biosensors for Lipopolysaccharides and Assays for Studies of Lipopolysaccharide Binding Interactions; Conservative Treatment of the Carpal Tunnel Syndrome A Review of the Literature from the Last 10 Years; Metabolomics in Bio-Medical Research: Challenges and Opportunities; Induction of Inflammatory Ascites with Macromolecules in Mice and Rats; How Beet Sugar Destroys the Basic Topology of Chromosomes; Index.

Read more less

Book Synopsis"Advances in Medicine and Biology" presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. This book presents and discusses topical data including: the use of complementary and alternative medicine among Chinese Canadians; evidence-based diagnostic test interpretation; angiotensin converting enzyme inhibitors for use as antihypertensive agents; membrane protein structure in the vitamin K cycle; the diagnostic value of the visual-vestibular interaction test with rotary chamber in the diagnosis of vertigo; the role of hair in the biological evolution of humans; and others.

Read more less

Book Synopsis"Advances in Medicine and Biology" presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum. This book presents and discusses data on topics such as: physical and bio-medical quantum mechanical information processing; advances in neurosurgical applications of functional magnetic resonance imaging of the human brain; pharmacological intervention in the management of neck pain disorders; affinity labeling as a tool to explore proteomic ensembles of DNA repair; a new topical ectoparasiticide for the control of fleas and ticks; measuring lipid bilayer thickness; treatment of tunga penetrans parasites; post-operative infectious cervical spine discitis; and others.

Read more less

Book Synopsis"Advances in Medicine and Biology" presents original research results on the leading edge of medicine and biology research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.

Read more less

Book Synopsis"Advances in Medicine and Biology" presents original research results on the leading edge of medicine and biology research. Each article has been carefully selected in an attempt to present substantial research results across a broad spectrum.

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. This compilation focuses on stem cell-like cells and plant regeneration; amputations in patients with diabetes mellitus; patient education in the internet age; diet, weight loss and non-alcoholic fatty liver disease; FCY receptors on human neutrophils; virtual nursing care; and digital dermatological photography.

Read more less

Book Synopsis

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include the effects of hypertension in patients with epistaxis; chronic supportive otitis media in children; the effect of menopausal hormone therapy on breast atrophy; therapeutic targets for Huntington''s Disease; catheter-related infections and mortality from congenital malformations in new-borns and infants.

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include serum ascorbic acid levels in selected surgical diseases; liver transplantation and therapy; background of orthodontic treatment; infectious complications in pregnancy; assessment of child dietary intake and the role of endothelin in regulating neutrophil recruitment to the lungs.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include independent macronodular adrenal hyperplasia as a rare cause of Cushing''s Syndrome; the pathophysiology of irritable bowel syndrome; language and literacy in preterm children; unexplained and iron deficiency anemia; adrenaline use in gastrointestinal endoscopy; supplementation with thyroid hormone in cardiac surgery; hormone replacement therapy; juvenile idiopathic arthritis and Short Bowel Syndrome.

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include calcium and cell aging; leptin in lizards; the homeostatic role of chemokines in the central nervous system; urethral lichen sclerosis and Vitamin C absorption and transportation in the body.

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed in this compilation include the electrochemical measurement of blood glucose for diabetic patients; ultrasound during lactation; polyphenols in the human diet; phosphocholine and immunomodulation of the immune system and pediatric outcomes of artificial reproductive technologies.

Read more less

Book Synopsis

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include the study of ceramics in biomedical research applications; HtrA as a chaperone and protease in bacterial pathogenesis; the role of the unfolded protein response in cell physiology, inflammation, hepatic disease, and renal transplantation; stroke prevention after cardiac surgery; recent developments in total hip arthroplasty; the effect of sonar on human hearing and fracture fixation in orthopaedic trauma surgery.

Read more less

Book Synopsis

Read more less

Book SynopsisThis continuing series gathers and presents original research results on the leading edge of medicine and biology. Each article has been carefully selected in an attempt to present substantial topical data across a broad spectrum. Topics discussed include new discoveries in endocrine disruptors; depressed brainstem auditory electrophysiology in cerebral palsy; control of aldosterone synthesis and secretion; health of Latino children of immigrants; biomechanics of the ankle and hindfoot and hypoplasia of the internal carotid artery.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less