Biology, life sciences Books

Book SynopsisStretch yourself to achieve the highest grades, with structured syllabus coverage, varied exam-style questions and annotated sample answers, to help you to build the essential skill set for exam success.- Benefit from expert advice and tips on skills and knowledge from experienced subject authors- Effectively manage your revision with a brand-new introduction that clearly outlines what is expected from you in the exam- Keep track of your own progress with a handy revision planner- Use the new glossary-index section to identify and address gaps in knowledge- Consolidate and apply your understanding of key content and skills with short ''Test yourself'' and exam-style questions

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Book SynopsisWith contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues due to legislative directives established over the past ten years.Covering all principal areas of EPA concern, Endocrine Toxicology, Third Edition provides: putative endocrine disruptors and mechanisms of endocrine toxicity the history and status of the regulatory process mechanisms of toxic effects in various hormonal systems comparisons of the endocrine responses in humans, livestock, and wildlife testing methods in mammalian, fish, avian, and amphibian models valuable insight into the approaches of various personnel in the field, iTrade Review "This is an excellent review of the effects of toxic substances on endocrine axes in both humans and wildlife.... The ambitious goals of covering the expanse of molecular toxicology and regulatory action are met by the book's diverse chapters......Because of the array of authors, the book serves as an excellent introduction to many areas related to endocrine toxicology....... The book does an excellent job of covering the topics in endocrine disruption that have become increasingly relevant over the last three decades. The classic mechanisms of endocrine disruption, namely alterations in estrogen and androgen signaling, are covered in two excellent chapters....As a whole, this book offers an excellent review of the effects of toxins on endocrine physiology with a particular strength in its coverage of government programs for monitoring these effects and the subsequent implications for regulatory policy. Because of the burgeoning knowledge in this area, this update is certainly appreciated, and subsequent editions will be welcome as our knowledge of endocrine disruption expands to other areas of endocrine physiology." Weighted Numerical Score: 94 - 4 Stars! [DOODY'S NOTES] [REVIEWER'S EXPERT OPINION]Robert Michael Sargis, M.D., Ph.D.(University of Chicago Medical Center) Table of ContentsRegulation of Endocrine Disruptive Chemicals in the United States. Pursuit of Endocrine Disruptors in Europe - the OECD Component. Impact of Endocrine Disruptor Policies and Regulations. The Hypothalamic-Pituitary-Gonadal Axis in Teleost Fish. The Hypothalamic-Pituitary-Gonadal Axis in Anuran Amphibians. The Hypothalamic-Pituitary-Gonadal Axis in Birds. The Hypothalamic-Pituitary-Gonadal Axis in Mammals. Comparing and Contrasting the Hypothalamic-Pituitary-Gonadal Axis in Different Vertebrate Classes. Male Reproductive Endpoints and the Rodent Hershberger Assay. Review of Bisphenol A by the National Toxicology Program. Pubertal Screening Assays in Rodents. Endocrine Disruption at Neuroendocrine and Neurotransmitter Sites. Endocrine Disruptor Interaction with Estrogen Receptors. Analysis of Endocrine Disruptors with Estrogen Reporter Systems. Time Dependent Embryotoxicity of the Endogenous Luteolysin, Prostaglandin F2alpha, in Ruminants. Actions of Endocrine Disruptors on the Thyroid Axis. Endocrine Disruption of Hormone Storage and Transport. Metal Toxicity in Mammalian Reproduction. Structure-Activity Modeling of Endocrine Disruptors. Overview of Endocrine Disruptor Ecotoxicity in Wildlife. Overview of USEPA Tests with Aquatic Vertebrates for Detecting and Assessing Endocrine Disrupting Chemicals. Biological Activity of Endocrine Disruptors in Aquatic Systems. Impact of Endocrine Disruptors on the Water Industry.

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Book SynopsisBrings together disparate conversations about wildlife conservation and renewable energy, suggesting ways these two critical fields can work hand in hand. Renewable energy is often termed simply green energy, but its effects on wildlife and other forms of biodiversity can be quite complex. While capturing renewable resources like wind, solar, and energy from biomass can require more land than fossil fuel production, potentially displacing wildlife habitat, renewable energy infrastructure can also create habitat and promote species health when thoughtfully implemented. The authors of Renewable Energy and Wildlife Conservation argue that in order to achieve a balanced plan for addressing these two crucially important sustainability issues, our actions at the nexus of these fields must be directed by current scientific information related to the ecological effects of renewable energy production. Synthesizing an extensive, rapidly growing base of research and insights from practitionerTrade ReviewA coming-together of noted authorities in [the energy and conservation] fields seeking a beneficial solution to both their respective purposes is heartening indeed. Given this, and all the information presented in its pages, Renewable Energy and Wildlife Conservation is a book that should be read by all who are professionally involved in both these fields as well as any others who are simply in search of a better understanding of two of the defining challenges of our age.—Johannes E. Riutta, The Well-Read NaturalistTable of ContentsList of ContributorsIntroduction. Renewable Energy and Wildlife ConservationChristopher E. Moorman, Steven M. Grodsky, and Susan P. RuppPART I BIOENERGY AND WILDLIFE CONSERVATION1 Short-Rotation Woody Crops and Wildlife ConservationRachel Greene, James A. Martin, and T. Bently Wigley2 Effects of Harvesting Forest-Based Biomass on Terrestrial WildlifeJessica A. Homyack and Jake Verschuyl3 Impacts on Wildlife of Annual Crops for Biofuel ProductionClint Otto4 Second-Generation Feedstocks from Dedicated Energy Crops:Implications for Wildlife and Wildlife HabitatSusan P. Rupp and Christine A. RibicPART II WIND ENERGY AND WILDLIFE CONSERVATION5 Wind Energy Effects on BirdsRegan Dohm and David Drake6 Wind Energy Effects on BatsCris D. Hein and Amanda M. Hale7 Effects of Wind Energy on Wildlife: Emerging Issues and Underrepresented TaxaNicole M. Korfanta and Victoria H. ZeroPART III SOLAR ENERGY, WATERPOWER, AND WILDLIFE CONSERVATION8 Solar Energy: A Technology with Multi-Scale Opportunities to Integrate Wildlife ConservationBrian B. Boroski9 Waterpower: Hydropower and Marine Hydrokinetic EnergyHenriette I. Jager and Lindsay M. WickmanPART IV THE FUTURE OF RENEWABLE ENERGY AND WILDLIFE CONSERVATION10 Renewable Energy Policy Directives: Implications for Wildlife ConservationEdward B. Arnett11 Renewable Energy Ecology: The Next Frontier in Wildlife ScienceSteven M. Grodsky, Sarah R. Fritts, and Rebecca R. HernandezIndex

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Book SynopsisTrade ReviewA practical and engaging guide for anyone who wants to study the ecology of small mammals....This is an excellent book that should stand the test of time.—Quarterly Review of BiologyWith 15 chapters on topics ranging from trapping and marking through to behavioral and genetic studies, this book acts as a sort of super literature review of approaches to small mammal study.—Community EcologyTable of ContentsAcknowledgmentsChapter 1. IntroductionChapter 2. Passive Methods of Small Mammal ResearchChapter 3. Active Detection TechniquesChapter 4. Lethal and Nonlethal Sampling for Genetics, Disease Studies, and Curatorial CollectionsChapter 5. Methods for MarkingChapter 6. Recording Anatomical and Reproductive FeaturesChapter 7. Design of Trapping StudiesChapter 8. Studying MovementsChapter 9. Estimating Population DemographicsChapter 10. Communities and the EnvironmentChapter 11. Dietary Studies on Small MammalsChapter 12. Small Mammal Behaviors: Personality, Activity, and FearChapter 13. Predator-Mediated Sampling of Small Mammal CommunitiesChapter 14. Ecological and Taxonomic Study of MorphologyChapter 15. Genetic Studies on Small MammalsAbout the AuthorsIndex

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Book SynopsisThis new edition of Biological Oceanography has been greatly updated and expanded since its initial publication in 2004. It presents current understanding of ocean ecology emphasizing the character of marine organisms from viruses to fish and worms, together with their significance to their habitats and to each other. The book initially emphasizes pelagic organisms and processes, but benthos, hydrothermal vents, climate-change effects, and fisheries all receive attention. The chapter on oceanic biomes has been greatly expanded and a new chapter reviewing approaches to pelagic food webs has been added. Throughout, the book has been revised to account for recent advances in this rapidly changing field. The increased importance of molecular genetic data across the field is evident in most of the chapters. As with the previous edition, the book is primarily written for senior undergraduate and graduate students of ocean ecology and professional marine ecologists.Trade Review“Due to its comprehensive nature, it is clear that this book will also succeed as a standard text for use in undergraduate and graduate marine science courses.” (Austral Ecology, 10 October 2014) “Overall I found it to be an immensely informative and entertaining read. This book will make an excellent core text for any graduate level course in Biological Oceanography whether introductory or advanced...I also think that every Biological Oceanographer should read it. It is an enlightening experience to view your field through the eyes of two colleagues who have been in this business for a long time. I also found reading this book a humbling experience. Charlie Miller and Pat Wheeler demonstrate an amazing depth and diversity of understanding in almost every topic that is taken up. I hope by the time I get to where they are in their careers I have achieved this level of scholarship in Biological Oceanography.” (Limnology and Oceanography Bulletin, 1 May 2013) “The book is extremely well referenced for further study and the impression is that most of the work cited is from within about the last twenty years. Altogether a worthy addition to any marine departmental library.” (British Ecological Society Bulletin, 1 December 2012)Table of ContentsPreface to the second edition vii Acknowledgements viii 1 Ocean ecology: some fundamental aspects 1 2 The phycology of phytoplankton 19 3 Habitat determinants of primary production in the sea 49 4 Numerical models: the standard form of theory in pelagic ecology 73 5 A sea of microbes: archaea, bacteria, protists, and viruses in the marine pelagial 96 6 The zoology of zooplankton 115 7 Production ecology of marine zooplankton 130 8 Population biology of zooplankton 158 9 Pelagic food webs 181 10 Biogeography of pelagic habitats 202 11 Biome and province analysis of the oceans 230 12 Adaptive complexes of meso- and bathypelagic organisms 276 13 The fauna of deep-sea sediments 292 14 Some benthic community ecology 321 15 Submarine hydrothermal vents 351 16 Ocean ecology and global climate change 367 17 Fisheries oceanography 396 References 427 Index 459

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Book SynopsisIn North America, concepts of Historical Range of Variability are being employed in land-management planning for properties of private organizations and multiple government agencies. The National Park Service, U.S. Fish & Wildlife Service, Bureau of Land Management, U.S. Forest Service, and The Nature Conservancy all include elements of historical ecology in their planning processes. Similar approaches are part of land management and conservation in Europe and Australia. Each of these user groups must struggle with the added complication of rapid climate change, rapid land-use change, and technical issues in order to employ historical ecology effectively. Historical Environmental Variation in Conservation and Natural Resource Management explores the utility of historical ecology in a management and conservation context and the development of concepts related to understanding future ranges of variability. It provides guidance and insights to all those entrusted with managing aTrade Review“The book provides a rich summary and critique of such ideas and approaches that will provide material both for under-graduate courses and for ecologists interested in the theory and practice of understanding historical ecological dynamics.” (Ecological Management & Restoration, 18 May 2015) “But each chapter provides guidance on how historical ecology may be fruitfully applied to specific cases of management giving the reader much hope for the future and for potential course corrections on the landscape.” (Landscape Ecol, 15 January 2015) "Overall, a very useful reference for advanced students in conservation and ecosystem management as well as researchers and managers developing future adaptation plans. Summing Up: Highly recommended. Upper-division undergraduates and above.” (Choice, 1 March 2013)Table of ContentsContributors, vii Foreword, x Preface, xii Acknowledgments, xiv SECTION 1 BACKGROUND AND HISTORY, 1 JOHN A. WIENS 1 Setting the stage: theoretical and conceptual background of historical range of variation, 3 WILLIAM H. ROMME, JOHN A. WIENS, AND HUGH D. SAFFORD 2 Development of historical ecology concepts and their application to resource management and conservation, 19 WAYNE PADGETT, BARBARA SCHRADER, MARY MANNING, AND TIMOTHY TEAR SECTION 2 ISSUES AND CHALLENGES, 29 HUGH D. SAFFORD 3 Challenges in the application of historical range of variation to conservation and land management, 32 GREGORY D. HAYWARD, THOMAS T. VEBLEN, LOWELL H. SURING, AND BOB DAVIS 4 Historical ecology, climate change, and resource management: can the past still inform the future? 46 HUGH D. SAFFORD, GREGORY D. HAYWARD, NICOLE E. HELLER, AND JOHN A. WIENS 5 What is the scope of "history" in historical ecology? Issues of scale in management and conservation, 63 JOHN A. WIENS, HUGH D. SAFFORD, KEVIN MCGARIGAL, WILLIAM H. ROMME, AND MARY MANNING 6 Native Americans, ecosystem development, and historical range of variation, 76 GREGORY J. NOWACKI, DOUGLAS W. MACCLEERY, AND FRANK K. LAKE 7 Conservation and resource management in a changing world: extending historical range of variation beyond the baseline, 92 STEPHEN T. JACKSON SECTION 3 MODELING HISTORIC VARIATION AND ITS APPLICATION FOR UNDERSTANDING FUTURE VARIABILITY, 111 ROBERT E. KEANE 8 Creating historical range of variation (HRV) time series using landscape modeling: overview and issues, 113 ROBERT E. KEANE 9 Modeling historical range of variability at a range of scales: an example application, 128 KEVIN MCGARIGAL AND WILLIAM H. ROMME SECTION 4 CASE STUDIES OF APPLICATIONS, 147 GREGORY D. HAYWARD 10 Regional application of historical ecology at ecologically defi ned scales: forest ecosystems in the Colorado Front Range, 149 THOMAS T. VEBLEN, WILLIAM H. ROMME, AND CLAUDIA REGAN 11 Incorporating concepts of historical range of variation in ecosystem-based management of British Columbia's coastal temperate rainforest, 166 ANDY MACKINNON AND SARI C. SAUNDERS 12 Incorporating HRV in Minnesota national forest land and resource management plans: a practitioner's story, 176 MARY SHEDD, JIM GALLAGHER, MICHAEL JIMÉNEZ, AND DUANE LULA 13 Applying historical fire-regime concepts to forest management in the western United States: three case studies, 194 THOMAS E. DEMEO, FREDERICK J. SWANSON, EDWARD B. SMITH, STEVEN C. BUTTRICK, JANE KERTIS, JEANNE RICE, CHRISTOPHER D. RINGO, AMY WALTZ, CHRIS ZANGER, CHERYL A. FRIESEN, AND JOHN H. CISSEL 14 Using historical ecology to inform wildlife conservation, restoration, and management, 205 BETH A. HAHN AND JOHN L. CURNUTT 15 River floodplain restoration experiments offer a window into the past, 218 RAMONA O. SWENSON, RICHARD J. REINER, MARK REYNOLDS, AND JAYMEE MARTY 16 Streams past and future: fluvial responses to rapid environmental change in the context of historical variation, 232 DANIEL A. AUERBACH, N. LEROY POFF, RYAN R. MCSHANE, DAVID M. MERRITT, MATTHEW I. PYNE, AND THOMAS K. WILDING 17 A framework for applying the historical range of variation concept to ecosystem management, 246 WILLIAM H. ROMME, GREGORY D. HAYWARD, AND CLAUDIA REGAN SECTION 5 GLOBAL PERSPECTIVES, 263 JOHN A. WIENS 18 Ecological history guides the future of conservation: lessons from Africa, 265 A.R.E. SINCLAIR 19 Ecological history has present and future ecological consequences – case studies from Australia, 273 DAVID LINDENMAYER 20 A view from the past to the future, 281 KEITH J. KIRBY 21 Is the historical range of variation relevant to rangeland management? 289 BRANDON T. BESTELMEYER 22 Knowing the Fennoscandian taiga: ecohistorical lessons, 297 YRJÖ HAILA SECTION 6 CHALLENGES FOR THE FUTURE, 305 23 Reflections on the relevance of history in a nonstationary world, 307 JULIO L. BETANCOURT 24 The growing importance of the past in managing ecosystems of the future, 319 HUGH D. SAFFORD, JOHN A. WIENS, AND GREGORY D. HAYWARD Index, 329 Colour plate pages fall between pp. 162 and 163

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Book SynopsisStatistical Foundations of Data Science gives a thorough introduction to commonly used statistical models, contemporary statistical machine learning techniques and algorithms, along with their mathematical insights and statistical theories. It aims to serve as a graduate-level textbook and a research monograph on high-dimensional statistics, sparsity and covariance learning, machine learning, and statistical inference. It includes ample exercises that involve both theoretical studies as well as empirical applications.The book begins with an introduction to the stylized features of big data and their impacts on statistical analysis. It then introduces multiple linear regression and expands the techniques of model building via nonparametric regression and kernel tricks. It provides a comprehensive account on sparsity explorations and model selections for multiple regression, generalized linear models, quantile regression, robust regression, hazards regression, Trade Review"This book delivers a very comprehensive summary of the development of statistical foundations of data science. The authors no doubt are doing frontier research and have made several crucial contributions to the field. Therefore, the book offers a very good account of the most cutting-edge development. The book is suitable for both master and Ph.D. students in statistics, and also for researchers in both applied and theoretical data science. Researchers can take this book as an index of topics, as it summarizes in brief many significant research articles in an accessible way. Each chapter can be read independently by experienced researchers. It provides a nice cover of key concepts in those topics and researchers can benefit from reading the specific chapters and paragraphs to get a big picture rather than diving into many technical articles. There are altogether 14 chapters. It can serve as a textbook for two semesters. The book also provides handy codes and data sets, which is a great treasure for practitioners."~Journal of Time Series Analysis"This text—collaboratively authored by renowned statisticians Fan (Princeton Univ.), Li (Pennsylvania State Univ.), Zhang (Rutgers Univ.), and Zhou (Univ. of Minnesota)—laboriously compiles and explains theoretical and methodological achievements in data science and big data analytics. Amid today's flood of coding-based cookbooks for data science, this book is a rare monograph addressing recent advances in mathematical and statistical principles and the methods behind regularized regression, analysis of high-dimensional data, and machine learning. The pinnacle achievement of the book is its comprehensive exploration of sparsity for model selection in statistical regression, considering models such as generalized linear regression, penalized least squares, quantile and robust regression, and survival regression. The authors discuss sparsity not only in terms of various types of penalties but also as an important feature of numerical optimization algorithms, now used in manifold applications including deep learning. The text extensively probes contemporary high-dimensional data modeling methods such as feature screening, covariate regularization, graphical modeling, and principal component and factor analysis. The authors conclude by introducing contemporary statistical machine learning, spanning a range of topics in supervised and unsupervised learning techniques and deep learning. This book is a must-have bookshelf item for those with a thirst for learning about the theoretical rigor of data science."~Choice Review, S-T. Kim, North Carolina A&T State University, August 2021Table of Contents1. Introduction. 2. Multiple and Nonparametric Regression. 3. Introduction to Penalized Least-Squares. 4. Penalized Least Squares: Properties. 5. Generalized Linear Models and Penalized Likelihood. 6. Penalized M-estimators. 7. High Dimensional Inference 8. Feature Screening. 9. Covariance Regularization and Graphical Models. 10. Covariance Learning and Factor Models. 11. Applications of Factor Models and PCA. 12. Supervised Learning. 13. Unsupervised Learning. 14. An Introduction to Deep Learning.

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Book SynopsisThe first comprehensive overview of an emerging field, Metabolic Medicine and Surgery introduces a new paradigm in patient management that crosses existing subspecialty boundaries. This approach is necessitated by the challenges of treating patients with obesity, metabolic syndrome, cardiovascular disease and prediabetes, as well as those with maldigestion, malabsorption, malnutrition and nutritional deficiencies. This book teaches physicians and surgeons what they need to know about clinical nutrition, metabolism and the metabolic effects of bariatric surgery. It is also applicable to those in primary care, including physicians, residents, medical students, nurses and nurse practitioners, physician assistants and dietitians who are on the front lines of treating patients with obesity, diabetes and cardiovascular disease.The book is presented in four sections: 1. An Overview of Metabolic Medicine and Surgery; 2. Metabolic Syndrome, Insulin Resistance and Obesity; 3. DiTrade Review"… an excellent, if not very dense, book. While this is a very fluid field characterized by important new discoveries and persistent questions, the authors have successfully summarized metabolic medicine, the complications of this condition, and the treatment options for patients. The book is perhaps best suited to bariatricians, but it would be an excellent choice for any individual caring for this patient population. Weighted Numerical Score: 83 - 3 Stars"—Doody’s ReviewTable of ContentsAn Overview of Metabolic Medicine. The Practice of Metabolic Medicine. The Concept of Metabolic Surgery. Metabolic Syndrome. Nonalcoholic Fatty Liver Disease. Insulin, the Glycemic Index, and Carcinogenesis. Nutrition and Cardiovascular Disease. The Risk Relationship between Insulin Resistance, Diabetes, and Atherosclerotic Cardiovascular Disease. Strategies for the Prevention of Type 2 Diabetes. Bariatric Surgery for Type 2 Diabetes Mellitus Resolution. Incretin Response after Bariatric Surgery. Medical Obesity Management. Peripheral Endocrine Response to Weight Loss. An Overview of Surgical Weight Loss Options. Diabetes Surgery. Metabolic Changes Post–Bariatric Surgery. Metabolic Monitoring of the Bariatric Surgery Patient. Hypoglycemia after Roux-en-Y Gastric Bypass Surgery. Micronutrient-Deficient Encephalopathy after Bariatric Surgery. Hyperammonemic Encephalopathy after Roux-en-Y Gastric Bypass Surgery. The Bedside Diagnosis of Malnutrition. Nutritional Support: Enteral and Parenteral Nutrition. Metabolic Effects of Omega-3 Fatty Acids. Nutrition and Gut Immunity. Nutrition Therapy for Inflammatory Bowel Disease. Nutritional Management of Short Bowel Syndrome in the Adult with Crohn’s Disease. Neurological Disease of Metabolism. Nutritional Approaches to Epilepsy. The Role of Nutritional Factors in Multiple Sclerosis. Micromineral Considerations in Alzheimer’s Dementia. Ingestion of Inorganic Copper from Drinking Water and Supplements Is a Major Causal Factor in the Epidemic of Alzheimer’s Disease. Zinc, Health, and Immunity. Index.

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Book SynopsisNeurovirology is an interdisciplinary field representing a melding of virology, clinical neuroscience, molecular pathogenesis, diagnostic virology, molecular biology, and immunology. Neuroviral Infections: General Principles and DNA Viruses covers recent developments in the area of neuroviral infections and discusses their role in related fields such as immunology, cell biology, and molecular biology. It offers a complete discussion of the major neuroviral infections caused by DNA viruses, including information on emerging basic principles, neuroviral infections, and future challenges in virology. Table of ContentsPrinciples of Viral Infections of the Nervous System: Neuroviral Infections: A Historical Perspective. Neuroviral Infections and Immunity. Controlling Neuroinflammation: Lessons from Rabies Virus. Laboratory Diagnosis of CNS Viral Infections. New Trends in Antiviral Therapy of CNS Infections. Animal Models of Viral Encephalitis. Neurotropic DNA Viruses and their Diseases: Herpes Simplex Virus and Human CNS Infections. CNS, Neurological Infections Caused by the Herpesvirus Varicella-Zoster Virus (VZV), and Models of VZV Neurotropism. Epstein–Barr Virus and CNS Infections. Cytomegalovirus (CMV) Infection. Human Herpesvirus 6A, 6B, and 7 Encephalitis. The Human Polyomavirus JC and Progressive Multifocal Leukoencephalopathy.

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Book SynopsisThe State of the Art in Transcriptome Analysis RNA sequencing (RNA-seq) data offers unprecedented information about the transcriptome, but harnessing this information with bioinformatics tools is typically a bottleneck. RNA-seq Data Analysis: A Practical Approach enables researchers to examine differential expression at gene, exon, and transcript levels and to discover novel genes, transcripts, and whole transcriptomes.Balanced Coverage of Theory and Practice.Each chapter starts with theoretical background, followed by descriptions of relevant analysis tools and practical examples. Accessible to both bioinformaticians and nonprogramming wet lab scientists, the examples illustrate the use of command-line tools, R, and other open source tools, such as the graphical Chipster software.The Tools and Methods to Get Started in Your Lab. Taking readers through the whole data analysis workflow, this self-contained guide provides a detailed oveTrade Review"Next-generation sequencing (NGS) is without doubt among the last decade’s most important technological advance in molecular biology, and RNA sequencing is its most common application, rapidly becoming an indispensable tool in drug discovery and biomarker identification. Given the complexity and fast-paced evolution of the NGS methodology, it may seem overwhelming to a novice to figure out where to get started. RNA-seq Data Analysis: A Practical Approach solves this problem: the single volume provides the reader with a wealth of details extending from the very fundamentals of NGS technology to comprehensive hands-on instructions on how to interpret your freshly baked sequencing reads. After reading this book, you will have all the necessary information to start putting RNA-seq to work answering your research questions."—Dr. Satu Nahkuri, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd."This is a fantastic book and a real resource for anyone embarking or already working in RNA-seq data analysis. It is a practical guide that provides layers of information to the reader to comprehend the different steps and options when analysing RNA-seq data. The content and style of the book are great and the authors clearly explain and provide well-rounded examples. This book stands out among others since it is very easy to follow and does not require a strong programming or statistical background. It is obvious the authors have experience with explaining and probably teaching others on how to perform RNA-seq analysis. I highly recommend this book to students, researchers, as well as trainers in RNA-seq data analysis."—Dr. Maria Victoria Schneider (Vicky), The Genome Analysis Centre, UK"It is really a very practical book for both wet lab biologists and computer scientists working on RNA-seq projects. The book is clearly written with a general introduction to RNA-seq in Chapter 1 and a brief description to RNA-seq data analysis in Chapter 2. Detailed information of computational methods, analysis pipelines, and software tools are presented in the remaining chapters with some real examples. I believe that this book will serve not only as a textbook for an introductory course of omics data analysis but also as a guideline for researchers working on RNA-seq projects."—Jingchu Luo, Professor, Peking University"RNA-seq is currently the best method for genome-wide transcriptional profiling of cells in about any organism. This book includes all the key steps, in generally the same organization, that we’ve found to be effective when training biologists and bioinformaticians in RNA-seq analysis. It’s a good guide and reference for RNA-seq that can get analysts started (or keep them going) while avoiding much of the time-consuming literature, documentation, and Web searches at each step of the pipeline. It covers a broad (but not overwhelming) selection of popular methods without the typical bias of an author’s research emphasis."—George W. Bell, Ph.D., Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA"In modern life sciences, it is increasingly the bioinformatics aspect that holds the essential key to successful research projects and discoveries, albeit often poorly understood, or even regarded as a ‘black box.’ This is precisely the point at which RNA-seq Data Analysis: A Practical Approach comes in. This book, a brilliant compilation of all different aspects of RNA-sequencing analyses, opens up this ‘black box’ and reveals all of its inner workings. It covers all the basic principles while maintaining a tight focus on the practical aspects of successful analyses, including discussing caveats and possible pitfalls. Following this spirit throughout, it is intuitively structured and easy to read, making it attractive both for researchers who want to quickly deepen their understanding of RNA-seq processing and for use as teaching material in the classroom for the scientists of the future."—Manfred Grabherr, Department of Medical Biochemistry and Microbiology, Uppsala University"I feel that this is a marvelous book and will be of invaluable use to support bioinformaticians, graduate students, and the occasional user of the RNA-seq technology. It has great depth of content and addresses the key areas of designing your study and making sense of the data. It covers the typical scenarios that a services bioinformatician is likely to encounter and I can see this book having a place on desks of scientists across academia and industry."—Stephen Rudd, Head of Computational Biology, University of Queensland"I strongly recommend RNA-seq Data Analysis: A Practical Approach to any scientist who plans to do sequencing experiments, even if he will not analyze the data by himself. The book gives in the first parts very important outlines of the sequencing technology and how it is working. … Going further, the book covers all state-of-the-art techniques of RNA-seq analysis in a very profound yet clear way and will be of great value even for the advanced bioinformatician as a reference work. … a must-have recommendation to everyone working in the molecular biology field … Even as a bioinformatician with over 15 years of experience in this field, I found many valuable details and some yet not known facts about sequencing data analysis."—Oliver Heil, Bioinformatician, German Cancer Research Center (DKFZ)"Many people are interested in applying RNA-seq to examine the transcriptome of their organism of interest but they are finding it difficult to apply it in their own laboratories. … In this book, RNA-seq is introduced by describing the different platforms and then the reader is taken in a systematic way through the process of analyzing RNA-seq data using several free open source tools. This book will be of interest to people starting with RNA-seq."—Dr. Etienne de Villiers, Bioinformatics Group Leader, KEMRI-Wellcome Trust Research Programme (KWTRP), and Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford"Next-generation sequencing (NGS) is without doubt among the last decade’s most important technological advance in molecular biology, and RNA sequencing is its most common application, rapidly becoming an indispensable tool in drug discovery and biomarker identification. Given the complexity and fast-paced evolution of the NGS methodology, it may seem overwhelming to a novice to figure out where to get started. RNA-seq Data Analysis: A Practical Approach solves this problem: the single volume provides the reader with a wealth of details extending from the very fundamentals of NGS technology to comprehensive hands-on instructions on how to interpret your freshly baked sequencing reads. After reading this book, you will have all the necessary information to start putting RNA-seq to work answering your research questions."—Dr. Satu Nahkuri, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd."This is a fantastic book and a real resource for anyone embarking or already working in RNA-seq data analysis. It is a practical guide that provides layers of information to the reader to comprehend the different steps and options when analysing RNA-seq data. The content and style of the book are great and the authors clearly explain and provide well-rounded examples. This book stands out among others since it is very easy to follow and does not require a strong programming or statistical background. It is obvious the authors have experience with explaining and probably teaching others on how to perform RNA-seq analysis. I highly recommend this book to students, researchers, as well as trainers in RNA-seq data analysis."—Dr. Maria Victoria Schneider (Vicky), The Genome Analysis Centre, UK"It is really a very practical book for both wet lab biologists and computer scientists working on RNA-seq projects. The book is clearly written with a general introduction to RNA-seq in Chapter 1 and a brief description to RNA-seq data analysis in Chapter 2. Detailed information of computational methods, analysis pipelines, and software tools are presented in the remaining chapters with some real examples. I believe that this book will serve not only as a textbook for an introductory course of omics data analysis but also as a guideline for researchers working on RNA-seq projects."—Jingchu Luo, Professor, Peking University"RNA-seq is currently the best method for genome-wide transcriptional profiling of cells in about any organism. This book includes all the key steps, in generally the same organization, that we’ve found to be effective when training biologists and bioinformaticians in RNA-seq analysis. It’s a good guide and reference for RNA-seq that can get analysts started (or keep them going) while avoiding much of the time-consuming literature, documentation, and Web searches at each step of the pipeline. It covers a broad (but not overwhelming) selection of popular methods without the typical bias of an author’s research emphasis."—George W. Bell, Ph.D., Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA"In modern life sciences, it is increasingly the bioinformatics aspect that holds the essential key to successful research projects and discoveries, albeit often poorly understood, or even regarded as a ‘black box.’ This is precisely the point at which RNA-seq Data Analysis: A Practical Approach comes in. This book, a brilliant compilation of all different aspects of RNA-sequencing analyses, opens up this ‘black box’ and reveals all of its inner workings. It covers all the basic principles while maintaining a tight focus on the practical aspects of successful analyses, including discussing caveats and possible pitfalls. Following this spirit throughout, it is intuitively structured and easy to read, making it attractive both for researchers who want to quickly deepen their understanding of RNA-seq processing and for use as teaching material in the classroom for the scientists of the future."—Manfred Grabherr, Department of Medical Biochemistry and Microbiology, Uppsala University"I feel that this is a marvelous book and will be of invaluable use to support bioinformaticians, graduate students, and the occasional user of the RNA-seq technology. It has great depth of content and addresses the key areas of designing your study and making sense of the data. It covers the typical scenarios that a services bioinformatician is likely to encounter and I can see this book having a place on desks of scientists across academia and industry."—Stephen Rudd, Head of Computational Biology, University of Queensland"I strongly recommend RNA-seq Data Analysis: A Practical Approach to any scientist who plans to do sequencing experiments, even if he will not analyze the data by himself. The book gives in the first parts very important outlines of the sequencing technology and how it is working. … Going further, the book covers all state-of-the-art techniques of RNA-seq analysis in a very profound yet clear way and will be of great value even for the advanced bioinformatician as a reference work. … a must-have recommendation to everyone working in the molecular biology field … Even as a bioinformatician with over 15 years of experience in this field, I found many valuable details and some yet not known facts about sequencing data analysis."—Oliver Heil, Bioinformatician, German Cancer Research Center (DKFZ)"Many people are interested in applying RNA-seq to examine the transcriptome of their organism of interest but they are finding it difficult to apply it in their own laboratories. … In this book, RNA-seq is introduced by describing the different platforms and then the reader is taken in a systematic way through the process of analyzing RNA-seq data using several free open source tools. This book will be of interest to people starting with RNA-seq."—Dr. Etienne de Villiers, Bioinformatics Group Leader, KEMRI-Wellcome Trust Research Programme (KWTRP), and Centre for Tropical Medicine, Nuffield Department of Medicine, University of OxfordTable of ContentsIntroduction. Quality Control. Mapping, and Assembly. Differential Expression. Analysis of Small Non-Coding RNAs.

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Book SynopsisExam Board: OCRLevel: A-LevelSubject: BiologyFirst Teaching: September 2015First Exam: Summer 2016With My Revision Notes: OCR A Level Biology A you can:- Manage your own revision with step-by-step support from experienced teacher and examiner Frank Sochacki- Apply biological terms accurately with the help of definitions and key words- Plan and pace your revision with the revision planner- Test understanding with questions throughout the book- Get exam ready with last minute quick quizzes available on the Hodder Education website

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Book SynopsisExam Board: CCEALevel: A-levelSubject: BiologyFirst Teaching: September 2016First Exam: June 2018Reinforce students'' understanding throughout their course; clear topic summaries with sample questions and answers will improve exam technique to achieve higher grades.Written by examiners and teachers, Student Guides: Help students identify what they need to know with a concise summary of the topics examined in the AS and A-level specification Consolidate understanding with exam tips and knowledge check questions Provide opportunities to improve exam technique with sample graded answers to exam-style questions Develop independent learning and research skills Provide the content for generating individual revision notes

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Book SynopsisLike the best-selling first two editions, A Handbook of Statistical Analyses using R, Third Edition provides an up-to-date guide to data analysis using the R system for statistical computing. The book explains how to conduct a range of statistical analyses, from simple inference to recursive partitioning to cluster analysis.New to the Third Edition Three new chapters on quantile regression, missing values, and Bayesian inference Extra material in the logistic regression chapter that describes a regression model for ordered categorical response variables Additional exercises More detailed explanations of R code New section in each chapter summarizing the results of the analyses Updated version of the HSAUR package (HSAUR3), which includes some slides that can be used in introductory statistics courses Whether you're a data analyst, scientist, or student, this handTrade Review“I truly appreciate how grounded in practicality this book is—and the way its chapters are structured really underlines this. Furthermore, all the datasets are interesting and vary widely in subject matter. If nothing else, this book is an excellent source of examples one might use to illustrate a variety of statistical techniques. … it offers a lot of good places to start if one wants to analyze data. … The book comes hand-in-hand with an R package, HSAUR3, with all the data and the code used in the text. The book is thus fully reproducible. Overall, it provides a great way for a statistician to get started doing a wide variety of things in the R environment. It would be particularly useful, then, for working statisticians looking to change their software. The book cites all the relevant packages one might need, which is quite nice for those attempting to navigate the vast array of packages freely available, and is quite clear in its presentation of the code. Between this and the datasets, it makes for quite a valuable and enjoyable reference.”—The American Statistician, August 2015"… a handy primer for using R to perform standard statistical data analysis. … students, analysts, professors, and scientists: if you are looking to add R to your toolkit for analyzing data statistically, then this book will get you there."—Kendall Giles on his blog, September 2014Praise for the Second Edition:"I find the book by Everitt and Hothorn quite pleasant and bound to fit its purpose. The layout and presentation [are] nice. It should appeal to all readers as it contains a wealth of information about the use of R for statistical analysis. Included seasoned R users: When reading the first chapters, I found myself scribbling small lightbulbs in the margin to point out features of R I was not aware of. In addition, the book is quite handy for a crash introduction to statistics for (well-enough motivated) nonstatisticians."—International Statistical Review (2011), 79"… an extensive selection of real data analyzed with [R] … Viewed as a collection of worked examples, this book has much to recommend it. Each chapter addresses a specific technique. … the examples provide a wide variety of partial analyses and the datasets cover a diversity of fields of study. … This handbook is unusually free of the sort of errors spell checkers do not find."—MAA Reviews, April 2011Table of ContentsAn Introduction to R. Data Analysis Using Graphical Displays. Simple Inference. Conditional Inference. Analysis of Variance. Simple and Multiple Linear Regression. Logistic Regression and Generalized Linear Models. Density Estimation. Recursive Partitioning. Scatterplot Smoothers and Additive Models. Survival Analysis. Quantile Regression. Analyzing Longitudinal Data I. Analyzing Longitudinal Data II. Simultaneous Inference and Multiple Comparisons. Missing Values. Meta-Analysis. Bayesian Inference. Principal Component Analysis. Multidimensional Scaling. Cluster Analysis. Bibliography. Index.

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Book SynopsisThe Physiology of Yoga is an evidence-based look at how yoga influences the body’s systems and positively affects health and well-being. Discover how to evaluate common claims about yoga and decide what works best for your body. Explore meditations, breathing exercises, and asanas as part of your mindful movement practice.Trade Review“This is the book I didn’t know I was waiting for! There are lots of books on yoga and anatomy but very few on yoga and physiology. This book beautifully meets the need. It is extensive and yet very accessible. I am pleased to add it to my library.”—Bernie Clark, Yoga Teacher and Author of the Your Body, Your Yoga Trilogy“At last! A thorough, evidence-based resource (complete with much-needed myth busting!) about the many systems of the body and how a yoga practice interacts with and influences them."—Jenni Rawlings, E-RYT, Cofounder of Strength for Yoga and Cohost of the Yoga Meets Movement Science Podcast“Every now and then, in the 40-odd years I’ve been practising yoga, I come across a book that makes an invaluable contribution to some aspect of my understanding of yoga. The Physiology of Yoga is just such a book. I give this book my highest recommendation; it’s an essential study guide and reference source for serious students and teachers, and it should be on the recommended reading list of every yoga teacher training program.”—Richard Rosen, Yoga Teacher and Author“This title fills a long-standing gap in the essential reading lists for yoga teacher training programs. Hopefully, it will prevent yoga teachers from repeating some of the most commonly held myths and misconceptions about the physiological effects of yoga practice.”—Leslie Kaminoff, Coauthor of Yoga Anatomy “Matthew and Andrew are world-class leaders in the field of yoga anatomy and physiology. Their clear and articulate perspective about the practice is matched only by their passion and undeniable service to teachers and dedicated practitioners worldwide. In the modern era of the yoga practice, it is reassuring to know that we have their work to guide us forward.”—Michael James Wong, Author, Educator, and Founder of Just Breathe and Krama Yoga“Andrew and Matthew have done the work so we can do what we do better. A physiology book for anyone with a keen interest in the body. Full of detailed descriptions, clear illustrations, and beautiful images to inspire you to keep moving.”—Naomi Annand, Yoga Teacher and Author of Yoga: A Manual for Life and Yoga for Motherhood“The Physiology of Yoga sheds light upon the latest scientific research on how yoga affects—or doesn't affect—our bodies. It is a must for the modern yoga teacher or practitioner who seeks to learn more about yoga and anatomy from a fresh perspective.”—Tatiana Avila Bouru, Yoga Teacher and Cofounder of Yoga With Alex and Tatiana“The Physiology of Yoga is a truly evidence-based resource that busts many myths. It delves into some big questions about movement that would be hard to answer accurately on Google! An essential guide for all yoga teachers—new and old—packed full of useful tips and practices.”—Kate Brandon, “The Physio Yogi,” Physiotherapist and Yoga Educator“What a brilliant, witty book! I really loved the dispelling of myths sections and the clear and concise illustrations. It was a sheer pleasure to read. I certainly learned a tremendous amount to update myself on the latest research and current principles of physiology. This book is sure to be a constant companion for an academic doing research in yoga and the avid yogi or yogi in training who wants to take a deeper dive into how yoga affects the body.”—Indira Subramanian, MD, Clinical Professor in the UCLA Department of NeurologyTable of ContentsChapter 1. Musculoskeletal SystemBoneJointsMusclesCartilageTendons, Ligaments, and AponeurosesFasciaThe Science of Stretching and FlexibilityPathologies, Injuries, and ConditionsConclusionChapter 2. Nervous SystemCells of the Nervous SystemCentral Nervous SystemPeripheral Nervous SystemNervous System ConditionsConclusionChapter 3. Respiratory SystemAnatomy and Physiology of the Respiratory SystemThe Biomechanics of Quiet BreathingAll About the DiaphragmForced Exhalation and InhalationAtmospheric Air and Expelled AirGood, Wholesome Oxygen?Ujjayi BreathingNose Breathing and Mouth BreathingThe Psychological and Physiological Effects of Pranayama and Slow BreathingPathologies and Conditions of the Respiratory SystemConclusionChapter 4. Cardiovascular SystemBloodHeartCirculationRole of the Cardiovascular System in Maintaining HomeostasisResting Heart Rate and Cardiac OutputHeart Rate VariabilityBlood PressureCardiovascular ConditionsConclusionChapter 5. Lymphatic and Immune SystemsLymphatic SystemImmune SystemConclusionChapter 6. Endocrine SystemWhat Is a Hormone?Cortisol: The Master HormoneInsulinThyroid HormonesEndorphins: Our Body’s MorphineDopaminePathologiesConclusionChapter 7. Reproductive SystemFemale Reproductive System AnatomyFemale Reproductive System PhysiologyMale Reproductive SystemReproductive System ConditionsConclusionChapter 8. Digestive SystemAnatomy and Physiology of the Digestive SystemDiet and the Digestive SystemPathologies and Gastrointestinal ProblemsConclusionChapter 9. Practice With ConfidenceStrong, Dynamic PracticeSlow Hatha PracticeChair Yoga PracticeRestorative Yoga PracticeConclusion

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Book SynopsisFundamentals of Clinical Psychopharmacology provides up-to-date, evidence-based and unbiased information about psychopharmacology. It spans the range of the discipline, from mode of action and side effects of drugs to meta-analyses of clinical trials. It is anchored to practice guidelines produced by the UK National Institute for Health and Care Excellence (NICE) and the British Association for Psychopharmacology (BAP). Care has been taken to provide an international perspective that makes it equally useful to practitioners in the US and other countries.The book grew out of BAP courses that set the standard for professional psychopharmacological education in the UK. This latest edition is fully updated and provides, in a concise and easy-to-read format, key facts about currently used psychotropic drugs, set in the context of the neuroscience of the disorders they treat. It also includes a new chapter on the principles of psychiatric prescribing. Key references, including the clinical studies discussed, are provided at the end of the chapter along with suggestions for further reading. Intended to be a frequently updated, affordable, concise and practical resource, it meets the needs of trainees and practitioners seeking to keep abreast of the state of the art in psychopharmacology.Trade Review"This is an excellent resource that is easy to read, succinct but complete, and is based solely on research findings. I have read many psychopharmacology books, but this is one of the best because of how well it compiles a vast amount of information in short chapters. While the chapters about specific medications and conditions are well written, the chapters on research and basic prescribing practices are exceptional and complement the other chapters."—Aaron Plattner, MD, Doody’s Book Reviews "Well-designed, well-written and well-edited reference book… a concise reference that achieves its stated aim of delivering an up-to-date review of the most current understanding of the state of psychopharmacology to meet the needs of the busy senior practitioner but also trainees." — (Winner of Psychiatry Category, BMA Medical Book Awards 2016)"This is an excellent resource that is easy to read, succinct but complete, and is based solely on research findings. I have read many psychopharmacology books, but this is one of the best because of how well it compiles a vast amount of information in short chapters. While the chapters about specific medications and conditions are well written, the chapters on research and basic prescribing practices are exceptional and complement the other chapters."—Aaron Plattner, MD, Doody’s Book Reviews Table of ContentsNeuropharmacology and Drug Action. Pharmacokinetics and Pharmacodynamics. Antipsychotics. Antidepressants and ECT. ‘Mood Stabilisers’ and Other Treatments for Bipolar Disorder. Anxiolytic and Hypnotic Drugs. Drugs of Abuse. Drugs for Dementia and Cognitive Impairment. Drugs Used for Personality Disorders and Behavioural Disturbance. Drug Treatments for Child and Adolescent Disorders. Prescribing in Clinical Practice. Clinical Trial Methodology.

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a huge range and FREE tracked UK delivery on ALL orders.

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Book SynopsisIntroduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercises, and References.New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of Trade Review"This is the most interesting to read and complete text I have found for senior undergraduate or early graduate-level coverage of protein structure and function, and a great reference book to have on hand. This text is significantly updated and printed in a hardcover format with easy-to-read text (larger font and pages than usual, with margins for note-taking) and comes with annotatable ebook access for free. Overall, this is a significantly enriched 2nd edition of a book we have used successfully for several years now, which I enthusiastically recommend!" --Leslie Kuhn, Departments of Biochemistry & Molecular Biology and Computer Science & Engineering, Michigan State University, USA "I used this book when studying for a course on the Mechanisms of Enzyme Catalysis. The book made everything I was struggling with so clear! It is extremely well organized and very, very thorough which makes studying from it easy! 10/10 would recommend to anyone studying proteins and/or enzymes, or even someone who just wants to learn more. Anyone looking for a supplementary reading for your course should have this text book - even if you think you don't need it, trust me, you do." --Customer review on Amazon.com Praise for the First edition: "This book offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses." --Barry Honig, Columbia University, New York, New York, USA "I’ve just lately used this textbook for a presentation on electrostatics. Although I have an organic background, I discovered that the explanations of electrostatic interactions are very clear and informative. The language isn’t too technical and may be easily understood by biology students. The textbook covers numerous examples and colorful illustrations, which made it easy to understand the principles discussed. The book is well organized in chapters for all the fundamental topics. I feel this book would be appropriate for any undergraduate and graduate scholar who’s keen on proteins. … It’s complete, easy to observe and (something I at least discover uncommon for textbooks) pleasing to read. The authors don’t shrink back from any subjects, but clarify things in a straightforward method supported by ample examples. Highly recommended." --Physics Book Reviews at dowdawgs.com, May 2013 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. …The book is clear, well organized, aptly illustrated in color, and a pleasure to read. The first two chapters are an impressive textbook unto themselves … The book is thoroughly documented with citations to the literature gathered at the end of each chapter. … Overall, this is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, Vol. 40, 2012 "This is an important book. It captures in a very accessible way a growing body of literature on the structure, function and motion of proteins, and links this to more established paradigms such as a reader might find in a mainstream biochemistry text. The text is littered with excellent examples of the wider relevance of the material covered. The book is also exceptionally well written. I learned new things from each chapter. Overall, a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers and instructors involved in structural biology or biophysics courses or in research on protein structure–function relationships. I would recommend it highly." --David Sheehan, ChemBioChem, 2011 "The book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic and includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. It provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. It is also easy for experts to dive into the more specialized aspects quickly. The book provides references to user-friendly web tools in the field. The publisher’s website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure, for parts of freshman biochemistry, and as a supplement for many undergraduate and graduate courses." --Burkhard Rost, Technische Universität München, Germany Table of ContentsIntroduction. Protein Structure. Methods of Structure Determination and Prediction. Energetics and Protein Stability. Protein Dynamics. Intrinsically Unstructured Proteins. Membrane-Bound Proteins. Protein-Ligand Interactions. Enzymatic Catalysis

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Book SynopsisTechniques of Crime Scene Investigation is a staple for any forensic science library and is routinely referenced by professional organizations as a study guide for certifications. It is professionally written and provides updated theoretical and practical applications using real casework. This text is a must-have for any CSI Unit or course teaching Crime Scene Investigation. â Kevin Parmelee, PhD, Detective (ret.), Somerset County, NJ Prosecutorâs OfficeSince the first English-language edition of Techniques of Crime Scene Investigation was published in 1964, the book has continued to be a seminal work in the field of forensic science, serving as a foundational textbook and reference title for professionals.This Ninth Edition includes several new chapters and has been fully updated and organized to present the effective use of science and technology in support of justice. New coverage to this edition addresses the debunking of a few forensTable of ContentsI: The Crime Scene 1. Introduction 2. First on Scene and Crime Scene Personnel 3. Documenting the Crime Scene 4. Physical Evidence Collection 5. Crime Scene Reconstruction II. Physical Evidence 6. Fingerprint Evidence 7. Blood, Forensic Biology, and DNA 8. Forensic Traces 9. Impression Evidence 10. Firearms Examination 11. Arson and Explosives 12. Illicit Drugs and Toxicology 13. Document Evidence III: The Investigation and Special Considerations 14. Ethics in Crime Scene Investigation 15. Sexual Assault Investigation 16. Burglary Investigation 17. Motor Vehicle Investigation 18. Death Investigation 19. Digital Evidence and the Electronic Crime Scene 20. Report Writing, Testimony and The Future App A. Equipment for Crime Scene Investigation App B. Forensic Science Related Websites

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Book SynopsisThose tasked with investigating death scenes come from a variety of backgrounds and varying levels of experience. Whether a homicide detective, crime scene investigator, medico-legal death investigator, coroner or medical examiner, Death Scene Investigation: Procedural Guide, Second Edition provides the investigator best-practice techniques and procedures for almost any death scene imaginable, including for deaths occurring even under the most unusual of circumstances.This Second Edition is fully updated to include new coverage on shallow graves, human remains at crime scenes, poisonings, expanded coverage of projectile weapons, videography, touch DNA, death notifications, and a newly added chapter dedicated to sexual deaths. In addition, the book serves as an on-scene ready reference which includes instructions on procedure including the initial notification of a death, processing the scene and body, the investigator''s role at autopsy, and analyzing Table of ContentsSection 1: Death Scene Investigation 1. Death Scene Response 2. Natural Deaths 3. Accidental Deaths 4. Suicidal Deaths 5. Homicidal Deaths Section 2: The Medicolegal Death Investigation 6. The Role of the Medicolegal Death Investigator 7. The Role of the Coroner 8. The Role of the Medical Examiner 9. Autopsy Protocol and the Investigator’s Role Section 3: Recovery of Human Remains 10. Searching for Human Remains 11. Surface Recovery of Human Remains 12. Recovery of Buried Human Remains 13. Aquatic Recovery of Human Remains 14. Post Mortem Changes Section 4: Wound Dynamics and Mechanisms of Injury 15. Asphyxiation 16. Sharp Force Injuries 17. Blunt Force Injuries 18. Chopping Injuries 19. Firearm Injuries – Rifle and Pistol 20. Firearm Injuries – Shotgun 21. Explosive Injuries 22. Thermal Injuries 23. Electrical Injuries 24. Poisoning 25. Drug Related Deaths Section 5: Special Death Investigations 26. Infant Death 27. Child Deaths 28. Child Sexual Abduction and Murder 29. Sexual Activities Resulting in Death 30. Rape and Sexual Assault Resulting in Death 31. Multiple Victim Death Scenes Section 6: Death Scene Management, Tasks and Responsibilities 32. Death Scene Management 33. Death Scene Sketching 34. Death Scene Photography 35. Death Scene Videography 36. Death Scene Notes and Observation Section 7: Death Scene Evidence Processing 37. Documenting and Processing Bloodstain Patterns at the Scene 38. Documenting and Processing the Shooting Scene 39. Documenting and Processing the Post Blast Scene 40. Entomological Evidence 41. Biological Evidence 42. Trace Evidence 43. Friction Ridge Evidence 44. Impression Evidence Section 8: Death Investigation Checklist Appendix A: Bloodborne Pathogens Appendix B: Bloodstain Pattern Decision Matrix Appendix C: Druggust Fold

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Book SynopsisExam board: International BaccalaureateLevel: IB DiplomaSubject: BiologyFirst teaching: September 2014First exams: Summer 2016Aim for the best Internal Assessment grade with this year-round companion, full of advice and guidance from an experienced IB Diploma Biology teacher.- Build your skills for the Individual Investigation with prescribed practicals supported by detailed examiner advice, expert tips and common mistakes to avoid.- Improve your confidence by analysing and practicing the practical skills required, with comprehension checks throughout.- Prepare for the Internal Assessment report through exemplars, worked answers and commentary. - Navigate the IB requirements with clear, concise explanations including advice on assessment objectives and rules on academic honesty.- Develop fully rounded and responsible learning with explicit reference to the IB learner profile and ATLs.

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Book SynopsisSupports Pearson Edexcel Level 3 Advanced GCE in Biology B (9BI0) specification.Build investigative skills, test understanding and apply biological theory to topical examples with the updated, all-in-one textbook for Years 1 and 2.Combining everything your students need to know for the Pearson Edexcel A level Biology B specification, this revised textbook will:- Support all 16 required practicals with activities and questions to help students explain procedures, analyse data and evaluate results.- Provide clear definitions, as well as explanations, of the meanings of all technical vocabulary needed for the specification.- Help bring students up to speed with a summary of prior knowledge and diagnostic questions at the start of each chapter.- Offer assessment guidance with exam practice questions at the end of each chapter, graded by difficulty to support progression.- Stretch more able students with new extended response and 'Challenge' questions.- Build mathematical skills with a dedicated 'Maths for Biology' chapter and support throughout, explaining key concepts and methods.- Develop and embed understanding with end-of-chapter summaries, free online access to 'Test yourself' answers and an extended glossary.

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Book SynopsisPocket-sized reference covers all pertinent aspects of gastrointestinal endoscopy. Provides discussions on informed concept, conscious sedation and monitoring, basic principles, the benign and malignant esophagus, gastrointestinal foreign bodies, lasers in endoscopy, and more.Table of ContentsInformed consent; conscious sedation and monitoring; cleaning and disinfection of endoscopes and accessories; antibiotic prophylaxis; principles of electrocautery; EGD - benign oesophagus; EGD - malignant oesophagus; EGD - stomach; oesophageal manometry; 24-hour pH testing; foreign bodies in the GI tract; endoscopic management of non-variceal upper GI bleeding; endoscopic management of lower GI bleeding; endoscopic management of variceal bleeding; lasers in endoscopy; endoscopy of the pregnant patient; PEG/PEJ; small bowel endoscopy; flexible sigmoidoscopy; colonoscopy; ERCP - introduction, equipment, normal anatomy; ERCP - benign diseases of the gall bladder and bile ducts; ERCP - malignant diseases of the pancreas, gall bladder and bile ducts; ERCP in benign pancreatic disease; endoscopic ultrasound - tumour staging; endoscopic ultrasound - submucosal tumours and thickened gastric folds; endoscopic ultrasound of the gall bladder and pancreas; liver biopsy; endoscopy of the paediatric patient.

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Book SynopsisAlthough many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory and applications. It also focuses on the assorted challenges that arise in analyzing longitudinal data.After discussing historical aspects, leading researchers explore four broad themes: parametric modeling, nonparametric and semiparametric methods, joint models, and incomplete data. Each of these sections begins with an introductory chapter that provides useful background material and a broad outline to set the stage for subsequent chapters. Rather than focus on a narrowly defined topic, chapters integrate important research discussions from the statistical literature. They seamlessly blend theory with applications and include examples and case studies from various disciplines. Destined to become a landmark publication in the field, this carefully edited collection emphasizes statistical models and methods likely to endure in the future. Whether involved in the development of statistical methodology or the analysis of longitudinal data, readers will gain new perspectives on the field.Trade ReviewThe scope is remarkable, and the degree of integration and polish is admirable. The contributors include many of the most innovative researchers in the field, and happily, many of the clearest writers as well. … a lively text with clear-eyed positions and well-argued recommendations on how to analyze data of specific structures. … [material] is all accessible, well explained, and well illustrated using examples … a very good book … an excellent resource for a graduate class for statisticians or biostatisticians, and as a reference for quantitatively minded researchers.—Statistics in Medicine, 2011The volume’s editors have assembled a world-class panel of contributors; many have made seminal contributions to the field (this includes the editors themselves). Immediately apparent is the uniformity of notation and writing style not typically found in volumes of this kind. The editors clearly have taken great care to ensure a whole document rather than a disjointed patchwork typical of similar collections. Chapters reflect contributor diversity while suppressing distracting idiosyncrasies. … Experienced researchers and those new to the field will find useful material here. … several chapters provide fresh insights. For graduate students and new researchers, the book provides a useful introduction and comprehensive reference material for the topics it covers. Case studies and software enable readers to implement some methods described in the book, with supplemental datasets and programs appearing on a useful website. … A strong inaugural volume for Chapman & Hall’s new series on modern statistical methods, Longitudinal Data Analysis provides an outstanding model for future entries.—Biometrics, September 2010… Longitudinal Data Analysis is the first book to collect and sort through many of the most important developments. The authors make clear the assumptions of the statistical methods and their consequences. Coupled with an abundance of examples, the book guides the practitioner about when to apply one method as opposed to another. The book has remarkable breadth and contains material that would likely be new even to those that analyze longitudinal data on a regular basis. Longitudinal Data Analysis would be useful for applied statisticians looking to expand their analytical toolkit and statistical researchers familiar with the area but looking for a good reference. …an excellent text for a special topics course for Ph.D. students in statistics. It has a good balance of statistical theory and applications, with a large number of real data examples and case studies to illustrate how to use the methods described therein. …a well organized, excellent overview of the state of the art in modeling longitudinal data and would make a useful supplement to the library of anyone that analyzes this type of data.—Journal of the American Statistical Association, June 2010…a concise but complete encyclopedia on longitudinal data analysis. The editors have made a great effort to produce a volume providing a comprehensive and up-to-date view of the theory and application of longitudinal data analysis. … One of the strengths of the book is the organizational structure and the fact that the book has been written by well-known experts in the field. … I find this book very useful for statisticians and researchers in many fields where the interest relies on studying the change of an outcome or multiple outcomes over time. Many of the chapters include examples and case studies in different disciplines and some of this material can be found in the website of this book (http://www.biostat.harvard.edu/ fitzmaur/lda). I would like to congratulate the editors and all the contributing authors for preparing this comprehensive handbook on many interesting and complementary aspects of the theory and applications of longitudinal data analysis. This handbook will have, without any doubt, an important place on the shelf of those statisticians and applied researchers working with longitudinal data.—Journal of Applied Statistics, Vo. 36, No. 10, October 2009This is public-service broadcasting at its best. Many of the leading internationally recognized experts in the field have been assembled to write a series of expository articles on an important area of modern statistics. … Care has clearly been taken to make the book hang together—it’s not like some ‘edited tomes’ consisting of a set of papers stapled together. There is a mixture of theory and applications with real data, some of which is available on a website. In my opinion the book will be a must-have for anyone seriously involved with repeated measures or longitudinal data.—International Statistical Review, 2009Other longitudinal data books do not have the breadth of this one. … I highly recommend this book to anyone interested in learning about modern methods for longitudinal data analysis. I think it would make a particularly good book for a Ph.D.-level reading course or as a supplement to a longitudinal data textbook in a graduate-level course. I especially recommend this book to statistical researchers, as it makes a great reference book.—Journal of Biopharmaceutical Statistics, Issue 4, 2009Table of ContentsIntroduction and Historical Overview. Parametric Modeling of Longitudinal Data. Nonparametric and Semiparametric Methods for Longitudinal Data. Joint Models for Longitudinal Data. Incomplete Data. Index.

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Book SynopsisApoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer''s disease and cancer. A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals.

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book Synopsis

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Book SynopsisIn nature, as in society, the parasites outnumber the hosts. John Janovy Jr. offers the parasites'' view of this situation. The result is smart, funny, and all too revealing. Elizabeth Kolbert, staff writer for The New Yorker and New York Times bestselling author of The Sixth ExtinctionThe answers to life's biggest questions can be found by looking at the little things Though you may not be able to see them with the naked eye, parasitesminuscule life forms that live inside other organismsinhabit our everyday lives. From headlice to bird droppings, litterboxes to unfiltered water, you have brushed up against the most common way of life on our planet.In this unique book, John Janovy Jr., one of the world's preeminent experts on parasites, reveals what humans can learn from the most reviled yet misunderstood animals on Earth: lice, tapeworms, flukes, and maggots that can eat a lizard from the inside, and how these lessons help us

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Book SynopsisThis popular resource has been comprehensively updated to cover the current CCEA A2 level Biology specification. Following the same content as the specification, the book is presented in full colour with over two hundred illustrations. This bright and clear layout will aid students’ understanding of the course. Sample examination questions are also provided throughout to reinforce learning and aid preparation for the exam. New material addressing the practical work in the A2 3 paper has been added to this edition. The author, Dr James Napier, is a well-known Biology author and a former teacher in a Northern Ireland Grammar School. Contents A2 1 Physiology, Co-ordination and Control, and Ecosystems Chapter 1 – Homeostasis and the Kidney Chapter 2 – Immunity Chapter 3 – Coordination and Control in Plants Chapter 4 – Neurones and Synapses Chapter 5 – The Eye and Muscle Chapter 6 – Populations and Communities Chapter 7 – Ecological Energetics and Nutrient Cycling A2 2 Biochemistry, Genetics and Evolutionary Trends Chapter 8 – Respiration Chapter 9 – Photosynthesis Chapter 10 – DNA as the Genetic Code (Protein Synthesis) Chapter 11 – Gene Technology Chapter 12 – Genes and Patterns of Inheritance Chapter 13 – Population Genetics Chapter 14 – The Plant and Animal Kingdoms Chapter 15 – StatisticsTable of ContentsContents: 1. Homeostasis and the Kidney 2. Immunity 3. Coordination and Control in Plants 4. Neurones and Synapses 5. The Eye and Muscle 6. Populations and Communities 7. Ecological Energetics and Nutrient Cycling 8. Respiration 9. Photosynthesis 10. DNA as the Genetic Code (Protein Synthesis) 11. Gene Technology 12. Genes and Patterns of Inheritance 13.Population Genetics 14. The Plant and Animal Kingdoms 15. Statistics

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Book SynopsisHigh throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.Table of ContentsPerspective/overview: State of the art in HTS at the academic-industry interface; Assay design and optimization; Assessment of available compound collections; Novel approaches to discovery and analysis of interesting compound combinations; Modern biophysical methods in target-based screening; Genetic perturbation methods; Understanding luminescence-based screens; Measuring interactions in live cells; Approaches to high-content imaging and multi-feature analysis; Profiling of genetically characterized cell systems; Multidimensional profile-based screening; Using biological systems that better recapitulate physiology; Phenotypic screens with model organisms; Encoded libraries; Modern virtual screening; Research data management; Small molecule bioactivity databases; Chemical biology in a pharma environment; Practical aspects of funding and executing high-throughput screens;

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Book SynopsisProvocative, ground-breaking and entertaining, the world’s leading expert on sexuality and the ovulation cycle reveals the hidden intelligence of hormones. In this paradigm-shifting book, Martie Haselton explains how hormonal intelligence works - both its strengths and its weaknesses - and shows women how to track and understand their desires, fears and perceptions with a radical new understanding of the biological processes that profoundly influence our behaviour. Rigorously researched, entertaining and empowering, Hormonal offers women deep new insights into their bodies, brains and relationships, and will encourage women everywhere to embrace the genius of female biology.Trade Review‘Such common sense is, sadly, remarkable.’ * Evening Standard *'Haselton is part of a new conversation that is emerging; she is a pioneering researcher pushing the politics of hormones in a new direction.' * Observer *'In her book she shows that there are no simple answers, but lots of fascinating possibilities, when we start to think about the biological aspects of our sexual lives.' * The Sunday Times *‘What a refreshing book. Finally, a feminist with the courage to discuss women not as victims of their hormones but as elegantly built captains of their minds and lives.’ * Helen Fisher, author of The First Sex and Why Him? Why Her? *'A very detailed and fascinating book which explores hormones to different level. Many women (and men) should read this to understand how women’s hormones can have both negative and positive effects on our lives.' * Dr Louise Newson, the Menopause Doctor *'Anchored in deep science, Haselton takes the reader on a mesmerizing tour from the stirrings of puberty to the aftermath of menopause, from sexual fantasies to the ways in which women often call the shots in the game of mating.' * David M. Buss, author of The Evolution of Desire *'Haselton shows there are no simple answers - but lots of fascinating possibilities - when we start to think about the biological aspects of our sexual lives.’ * Alice Dreger, author of Galileo's Middle Finger *'In Hormonal, Martie Haselton gives us a brave and fascinating tour of what we know we know about sex differences, but are often afraid to discuss. Read it, whether or not you have a uterus.' * am Harris, author of five New York Times bestsellers and host of the Waking Up podcast *'This book is essential reading for both women and men...Hormonal is engaging, clever, very funny at times, and always scientifically impeccable.' * Barbara Natterson-Horowitz, author of New York Times bestseller Zoobiquity *‘Your hormones have a lot to answer for, and you'll struggle to find someone to give you a better schooling than UCLA professor Martie Haselton.’ * Women's Health *'Deep, thoughtful, and eye-opening, this book teaches us that the more we know about hormones, the more we can manage our lives.' * Maria Shriver, author of I've Been Thinking... *'A smart and engaging scientific story about the amazing molecules that drive our behaviour.' * Daniel Gilbert, author of Stumbling on Happiness *'Written with passion and wit, Hormonal provides important insights about the female experience.' * Joan Silk, professor, School of Human Evolution and Social Change, Arizona State University, and co-author of How Humans Evolved *

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Book SynopsisWhere rivers flow over rock, the combined action of water and sediment can create intricate and beautiful natural sculptures. Some of the most striking forms are potholes: roughly circular depressions carved into the rocky beds of turbulent, upland rivers.

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Book SynopsisHuman biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine and blood. The analytical methods for detection of substances in biological media have considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and currently used in surveillance programs all over the world. This two volume set provides an overview of current available biomarkers and human biomonitoring programs in environmental health, which is timely given the present debate on adverse health effects from environmental exposures. The books decribe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume one describes current human biomonitoring programs in Germany, Romania, France, Canada, India and Belgium, providing convincing evidence of a global decline in human exposures to lead and increasing concern from exposure to endocrine disruptors and the genotoxic compound. Biomarkers of specific exposures to a wide range of widely used everyday compounds such as phthalates, PFCs, bisphenol A, brominated flame retardants, PAHs, dioxins, mercury and arsenic are also discussed. Volume two decribes human biomonitoing of exposures to environmental tobacco smoke, mycotoxins, physiological stress, hormone activity, oxidative stress and ionizing radiation, as well as effect biomarkers of hemoglobin adducts, germ cells, micronuclei and individual susceptability. The books will be essential reading for toxicologists, environmental scientists and all those working in the safety and risk assessment of chemicals.Table of ContentsBiomarkers of exposure - Hemoglobin adducts; Biomarkers of human exposure to environmental tobacco smoke (ETS); Biomarkers of exposure û mycotoxins: aflatoxin, deoxynivalenol and fumonisins; Biological measures and the psychosocial working environment; Micronuclei for human biomonitering; Biomarkers of individual susceptibility: genetic polymorphisms and their interplay with micronucleus frequencies Biomarker of effects on hormone functions; Biomarkers of Exposure - Oxidative Stress to DNA and Lipids û Relation to Air Pollution; Male and female germ cell biomarkers Biomarkers of exposure and effect: ionizing radiation; Ethics and data protection in human biomarker studies

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Book SynopsisPatent Transactions in the Life Sciences is designed to provide guidance on the structure and detail of those agreements in the life sciences sector that are based on its most import assets - patents and know-how. As a companion to Intellectual Property in the Life Sciences, it is intended to cover the practical what, where, why and when of patent transactions in this sector, under the leading legal regimes. The book explains the rights that underpin life sciences transactions and describes the architecture, features and purpose of those transactions. It covers issues from the basics of a licence and assignment to complex agreements. The book also explores the types of deal that commonly feature in the industry at the corporate level and how patents fit in. Associated issues of licence disputes, competition rules, securitisation, insolvency and taxation are also examined. This new guide will be a valuable resource for lawyers, in-house counsel and other professionals advising on transactions in the life sciences industry, particularly where they have global reach.Table of ContentsIntroduction 5 Paul England Taylor Wessing Looking ahead to 13 the unitary patent Paul England Taylor Wessing Belgium 19 Philippe de Jong Christophe Ronse ALTIUS Canada 35 Rory Cattanach Kevin Fritz Wildeboer Dellelce LLP Noel Courage Bereskin & Parr LLP China and Hong Kong 51 Joanna Chan Lewis Ho Monique Lee Dechert LLP Denmark 85 Klaus Ewald Madsen Christian Bennet Rosenbak Bech-Bruun France 99 Laetitia Benard Allen & Overy LLP Germany 121 Nicole Battistini-Kohler Manja Epping Michael Gaul Christof Hohne Matthias Hulsewig Anja Lunze Steffen Wirsing Taylor Wessing India 153 Disket Angmo Fiona Desouza Jose Madan Khaitan & Co Israel 169 Uri Fruchtman Liad Whatstein Dr Shlomo Cohen & Co Italy 191 Luca Trevisan Trevisan & Cuonzo Japan 209 Frederick Ch'en Eiichiro Kubota Hogan Lovells Netherlands 237 Carreen Shannon Deterink South Korea 255 Mikyung Choe H Joon Chung Yoon Young Huh Ji Eun Kim Jongguk Pak Kim & Chang Sweden 271 Jennie Klingberg Odd Swarting Setterwalls Switzerland 285 David Broenimann Christoph Heiz Simon Holzer Kilian Scharli Andrea Sieber Meyerlustenberger Lachenal United Kingdom 303 Malcolm Bates Colin McCall Louisa Penny James Stewart Tim Worden Taylor Wessing LLP United States 343 Chuck Larsen Anita Varma Ropes & Gray LLP About the authors 373

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Book SynopsisThis book is aimed at those who wish to understand more about the molecular basis of life and how life on earth may change in coming centuries. Readers of this book will gain knowledge of how life began on Earth, the natural processes that have led to the great diversity of biological organisms that exist today, recent research into the possibility of life on other planets, and how the future of life on earth faces unprecedented pressures from human-made activities. Readers will obtain a perspective on the potential risks of chemical or nuclear warfare, and the ever-increasing risks from human activities that are causing pollution and climate change with global heating. Readers will also learn about ongoing research efforts to generate “designer lifeforms” through synthetic biology and applications of artificial intelligence. The book makes an integrated, up-to-date, overview of topics often considered as separate fields. It should be valuable to students, teachers, and people who are concerned about the future of life.Table of ContentsIntroduction.- Early Ideas About the Origin of Life.- The Scientific View of the Origin of Life.- Biological Evolution.- Manipulated Evolution and Artificial Life.- Natural Risks to Life.- Human-made Risks from Nuclear and Chemical Warfare.- Human-made Risks and Climate Change with Global Heating.- Artificial Intelligence: Opportunity or Risk?- Life on Other Planets.- Outlook.

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