Biochemistry Books
De Gruyter Environmental and Biochemical Toxicology: Concepts, Case Studies and Challenges
Book SynopsisThis text coherently links biochemical fundamentals and mechanisms with economic and societal problems of environmental pollution. It addresses interdisciplinary topics such as regulatory problems, sampling and pollutant quantifi cation, model organisms and provides a philosophical perspective on the toxin load on a variety of organisms, including humans in the environment in the Anthropocene. Case studies and exercises illustrate current issues and discuss future aspects.
£73.62
De Gruyter Biomaterial Science: Anatomy and Physiology Aspects
Book SynopsisThis book bridges the gap between a clinician’s and material scientists’ knowledge by elucidating upon the different biomaterials used in anatomical systems and how those materials react to the human body. It explores both established and future prospective of biomaterial types/designs, and considerations in material selection and synthesis, to guide students from non-clinical background in understanding the relations of material science and the human body.
£122.07
De Gruyter Handbook of Nanoethics
Book SynopsisWith nanotechnology being a relatively new field, the questions regarding safety and ethics are steadily increasing with the development of the research. This book aims to give an overview on the ethics associated with employing nanoscience for products with everyday applications. The risks as well as the regulations are discussed, and an outlook for the future of nanoscience on a manufacturer’s scale and for the society is provided. Handbook of Nanoethics is perfect for , academicians and scientist, as well as all other industry professionals and researchers. It is a good introduction for newcomers in the field who do not want to dive deep into the details but are eager to understand the ethical challenges and possible solution related to nanotechnology and ethics.
£65.55
£79.32
De Gruyter Cannabis Chemistry and Biology: Fundamentals
Book SynopsisThis book serves as an introduction to graduate students and early career researchers on chemistry and botany of the cannabis plant. Cannabis botany, propagation, biotechnology, chemistry, cannabinoids and their biosynthesis, chemovars of cannabis and their identification as well as the other chemical classes of compounds known to exist in the plant. Analytical method are discussed to establish identity and Potency changes over the years in the United States. This book will build a base of knowledge on the complexity of cannabis chemistry. Features Introduction to the fundamental chemistry and botany of Cannabis. State of the art research on Cannabis sativa. The history, botany, major chemical classes of cannabis as well as methods of analysis and potency trends over several decades in the United States. Written by prominent scientists in the field of cannabis. The Cannabis Chemistry Subdivision of the American Chemical Society recently founded in 2022 the ElSohly Award sponsored by Heidolph North America in honour of Prof. Mahmoud A. ElSohly. This award provides researchers, students, and industry professionals with resources to present their work at the Spring National Meeting of the American Chemical Society at the ElSohly Award Symposium. More information: https://cann-acs.org/wp-content/uploads/2020/12/CANN-Postcard-Award.pdf
£70.77
De Gruyter Bioinorganic Chemistry: Some New Facets
Book Synopsis The book includes several topics as per Universities curriculum of M.Sc. and M.Phil. course work in Chemistry. This covers different Physiological aspects of Bioinorganic Chemistry in terms of 4 Chapters with in-depth and up-to-date coverage. The book symmetrically presents (i) Coordination chemistry of chlorophylls/bacteriochlophylls and its functional aspects in photosynthesis, (ii) Complexes containing nitric oxide: Synthesis, reactivity, structure, bonding, and therapeutic aspects of nitric oxide releasing molecules (NORMS) in human beings and plants, (iv) Complexes containing carbon monoxide: Synthesis, reactivity, structure, bonding, and therapeutic aspects of carbon monoxide releasing molecules (CORMS) in human beings and plants, and (iv) Advantageous role of gaseous signaling molecule, H2S: Hydrogen sulphide and their respective donors, in ophthalmic diseases and physiological implications in plants. At the end, three relevant topics are included as appendices for updating students and faculty members.
£61.28
£69.35
£56.52
De Gruyter Biomimetic Nanotechnology: Senses and Movement
Book SynopsisThis is an interdisciplinary book for biomimetic nanotechnology, that correlates the biology on the molecular scale with nanotechnology mimicking human senses and movement. The introduction provides the background in life science, chemistry, material science, and engineering needed to understand sensors and movement on the molecular level. The chapters discuss human movement, vision, smell and taste, hearing, and touch. Each chapter explains the sense or movement on the molecular level, then discusses nanotechnology that uses the human molecules or mimics the function of the human sense and movement on the nanoscale. This is an excellent book for senior undergraduates and graduate students in the life sciences, chemistry, material sciences, and engineering. It will also appeal to any reader with an interest in life sciences and nanotechnology.
£65.55
De Gruyter Riedel Moderne Anorganische Chemie
Book Synopsis
£84.55
De Gruyter Biomolecules: From Genes to Proteins
Book Synopsis Biochemistry is the study of the structure and functions of biological macromolecules such as nucleic acids, proteins, carbohydrates and lipids. The book is organized in five chapters which covers the basic concepts and fascinating chemistry of biomolecules. It also exposes students to different metabolic pathways and concept of energy in biological system, and provides valuable material for the students of Chemistry, Biochemistry, Biotechnology and Bioscience.
£54.62
De Gruyter Chemistry and Biochemistry of Food
£86.45
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Molekular- und Zellbiologie: Aktuelle Themen
Book SynopsisTable of ContentsFunktionsanalyse zellulärer Strukturproteine durch Mikroinjektion.- Methoden zur Charakterisierung von membranständigen Rezeptoren: Biochemische Charakterisierung und Reindarstellung des Acetyl-LDL-Rezeptors von Makrophagen.- Isolation und Charakterisierung differenzierungsspezifischer Antigene der Milchdrüse.- Sequenzieren von DNA.- Mathematische und informationstheoretische Hilfsmittel zur DNA-Sequenzierung und Sequenzanalyse.- Vektor-Wirt Systeme zur DNA-Klonierung in E. coli.- Zelloberflächenproteine — Klonierung ihrer Gene durch DNA vermittelten Gentransfer und fluoreszenzaktivierte Zellsortierung.- Linkshelikale Z-DNA: „DNA-Supercoiling“ und Bindung von Anti-Z-DNA Antikörpern.- Mikroklonierung von Chromosomenabschnitten.- Molekular- und Cytogenetik sortierter Methaphasenchromosomen.- Chromosomenspezifische DNA-Bibliotheken in der Humangenetik.- Gen-Injektion und Transkript-Analyse in der Xenopus-Oocyte.- Gentransfer in eukaryotische Seilen.- SV40 als Modellsystem zum Studium eukaryontischer Genregulation.- Hormonal gesteuerte Transkription — Definition der regulatorischen Sequenzen im Genom des Maus-Mammatumorvirus.
£46.99
VDM Verlag Blood and Tissue Nitric Oxide Products
£46.52
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Lipid Signaling in Plants
Book SynopsisPhospholipidshavelongbeenknownfortheirkeyroleinmaintainingthebilayer structureofmembranesandinphysicallyseparatingthecytosolfromorganelles andtheextracellularspace. Inthepastdecade,acompletelynovelandunexpected functionemerged,full?llingacrucialroleincellsignaling. Itwasthediscoveryin animalcells,thatagonist-activatedcellsurfacereceptorsledtotheactivationofa phospholipase C (PLC), to hydrolyze the minor lipid, phosphatidylinositol 4- bisphosphateintotwosecondmessengers,inositol1,4,5-trisphosphate(InsP)and 3 2+ diacylglycerol(DAG). WhileInsP diffusesintothecytosol,whereitreleasesCa 3 2+ from an intracellular store by activating a ligand-gated Ca -channel, DAG remainsinthemembranetorecruitandactivatemembersoftheproteinkinase Cfamily. Overtheyears,avarietyofotherlipidbased-signalingcascadesweredisc- ered. Theseinclude,phospholipaseA,generatinglyso-phospholipidsandfreefatty acids(tobeconvertedintoprostaglandinsandleukotrienes),phospholipaseD,to generatethelipidsecondmessenger,phosphatidicacid(PA),andphosphoinositide 3-kinase (PI3K), generating a distinct set of polyphosphoinositides (PPI) ph- phorylated at the D3-position of the inositol ring, all with separate signaling functions. Sphingolipids,representinganotherimportantgroupofsignalinglipids, alsocameacross. Themajorityoftheselipid-basedsignalingpathwayshavebeendiscoveredin plantcellstoo. Moreover,theyhavebeenfoundtobeactivatedinresponsetoa widevarietyofbioticandabioticstresssignals,butalsotobebasicallyinvolvedin plantgrowthanddevelopment. Whilemanyoftheenzymes,lipids,andtheirtargets involved arewell conserved, major differences with the mammalian paradigms havealsoemerged. Thisbookhighlightsthecurrentstatusofplantlipidsignaling. Allchaptershave beenwrittenbyexpertsinthe?eldandcoverinformationforbothbeginnersand advancedlipidologists. PartIincludesphospholipases(Chaps. 1-3),partII,lipid kinases (Chaps. 4-7), part III, lipid phosphatases (Chaps. 8-9), part IV, ix x Preface inositolphosphates and PPI metabolism (Chaps. 10-13), part V, PA signaling (Chaps. 14-17),andpartVI,additionallipidsignals,e. g. oxylipins,NAPEand sphingolipids(Chaps18-20). Ithasbeenagreatpleasuretobetheeditorofthis bookandtobeawitnessofthislipid-signalingadventure. Amsterdam,June2009 TeunMunnik Contents PartI Phospholipases PhospholipaseAinPlantSignalTransduction...3 Gu..ntherF. E. Scherer TheEmergingRolesofPhospholipaseCinPlantGrowth andDevelopment...23 PeterE. DowdandSimonGilroy PlantPhospholipaseD...39 WenhuaZhang,XiaoboWan,YueyunHong,WeiqiLi,andXueminWang PartII Kinases Phosphatidylinositol4-PhosphateisRequiredforTip GrowthinArabidopsisthaliana ...65 AmyL. SzumlanskiandErikNielsen PIP-KinasesasKeyRegulatorsofPlantFunction ...79 TillIschebeckandIngoHeilmann PlantPhosphatidylinositol3-Kinase...95 YureeLee,TeunMunnik,andYoungsookLee DiacylglycerolKinase...107 StevenA. AriszandTeunMunnik xi xii Contents PartIII Phosphatases SignalingandthePolyphosphoinositidePhosphatasesfromPlants ...117 GlendaE. Gillaspy PhosphatidicAcidPhosphatasesinSeedPlants...131 YukiNakamuraandHiroyukiOhta PartIV PPIMetabolism InsP inPlantCells ...145 3 YangJuIm,BrianQPhillippy,andImaraYPerera InositolPolyphosphatesandKinases...161 JillStevenson-PaulikandBrianQ. Phillippy PhosphoinositidesandPlantCellWallSynthesis ...175 RuiqinZhong,RyanL. McCarthy,andZheng-HuaYe ImagingLipidsinLivingPlants ...185 JoopE. M. VermeerandTeunMunnik PartV PASignaling PhosphatidicAcid:AnElectrostatic/Hydrogen-BondSwitch?...2 03 EdgarEduardKooijmanandChristaTesterink NitricOxideandPhosphatidicAcidSignalinginPlants...223 AyelenM. Diste'fano,M. LucianaLanteri,ArjentenHave, CarlosGarc?'a-Mata,LorenzoLamattina,andAnaM. Laxalt 3-Phosphoinositide-DependentProteinKinaseisaSwitchboard fromSignalingLipidstoProteinPhosphorylationCascades...243 ChristineZalejskiandLa'szlo'Bo..gre PartVI AdditionalLipidSignals DiacylglycerolPyrophosphate,ANovelPlantSignalingLipid...263 EmmanuelleJeannette,SophieParadis,andChristineZalejski OxylipinSignalingandPlantGrowth...277 AlinaMosblech,IvoFeussner,andIngoHeilmann Contents xiii FattyAcidAmideHydrolaseandtheMetabolismof N-AcylethanolamineLipidMediatorsinPlants...293 KentD. ChapmanandElisonB. Blanca?or SphingolipidSignalinginPlants...307 LouiseV. MichaelsonandJohnathanA. Napier Index ...323 Contributors Steven A. Arisz Section Plant Physiology, Swammerdam Institute for Life Sciences,UniversityofAmsterdam,SciencePark904,NL-1098XH,Amsterdam, TheNetherlands ElisonB. Blanca?or SamuelRobertsNobleFoundation,PlantBiologyDivision, Ardmore,OK73401,USA,eblanca?or@noble.Table of ContentsPhospholipases.- Phospholipase A in Plant Signal Transduction.- The Emerging Roles of Phospholipase C in Plant Growth and Development.- Plant Phospholipase D.- Kinases.- Phosphatidylinositol 4-Phosphate is Required for Tip Growth in Arabidopsis thaliana.- PIP-Kinases as Key Regulators of Plant Function.- Plant Phosphatidylinositol 3-Kinase.- Diacylglycerol Kinase.- Phosphatases.- Signaling and the Polyphosphoinositide Phosphatases from Plants.- Phosphatidic Acid Phosphatases in Seed Plants.- PPI Metabolism.- InsP3 in Plant Cells.- Inositol Polyphosphates and Kinases.- Phosphoinositides and Plant Cell Wall Synthesis.- Imaging Lipids in Living Plants.- PA Signaling.- Phosphatidic Acid: An Electrostatic/Hydrogen-Bond Switch?.- Nitric Oxide and Phosphatidic Acid Signaling in Plants.- 3-Phosphoinositide-Dependent Protein Kinase is a Switchboard from Signaling Lipids to Protein Phosphorylation Cascades.- Diacylglycerol Pyrophosphate, A Novel Plant Signaling Lipid.- Additional Lipid Signals.- Oxylipin Signaling and Plant Growth.- Fatty Acid Amide Hydrolase and the Metabolism of N-Acylethanolamine Lipid Mediators in Plants.- Sphingolipid Signaling in Plants.
£123.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Synergetics: Introduction and Advanced Topics
Book SynopsisThis book is an often-requested reprint of two classic texts by H. Haken: "Synergetics. An Introduction" and "Advanced Synergetics". Synergetics, an interdisciplinary research program initiated by H. Haken in 1969, deals with the systematic and methodological approach to the rapidly growing field of complexity. Going well beyond qualitative analogies between complex systems in fields as diverse as physics, chemistry, biology, sociology and economics, Synergetics uses tools from theoretical physics and mathematics to construct an unifying framework within which quantitative descriptions of complex, self-organizing systems can be made. This may well explain the timelessness of H. Haken's original texts on this topic, which are now recognized as landmarks in the field of complex systems. They provide both the beginning graduate student and the seasoned researcher with solid knowledge of the basic concepts and mathematical tools. Moreover, they admirably convey the spirit of the pioneering work by the founder of Synergetics through the essential applications contained herein that have lost nothing of their paradigmatic character since they were conceived.Table of ContentsAn Introduction.- Advanced Topics.
£85.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Electrocommunication in Teleost Fishes: Behavior and Experiments
Book SynopsisSome fishes test their environment by generating electric fields outside their bodies (man's first contact with electricity). To send and receive electric signals, one's own or those from a neighbor, is the basis of some bony fishes' unusual sensory capacities that enable them to lead a secret, nocturnal life. This volume provides the reader with a detailed account of these fishes' biology and behavior and their sophisticated sensory capacities. The phylogenetic relationships of the fish taxa involved are discussed as well as the physiology and anatomy of the electrosensory-motor-system and the integration to form an efficient intelligence system. The main emphasis is on the descriptive and experimental analysis of electric communication behavior in a variety of species, including studies of digital signal synthesis. Whenever possible, mechanisms of communication are indicated.Table of Contents1. Taxonomy of Electroreceptive Teleosts.- 1.1 Osteoglossiformes.- 1.2 Mormyriformes.- 1.3 Gymnotiformes.- 1.4 Siluriformes.- 2. Electric Sensori-Motor System.- 2.1 Electroreception in Evolutionary Perspective.- 2.1.1 Cranial Nerves and Somatic Distribution of Electroreceptors in Teleosts.- 2.1.2 Structure of Electroreceptors in Teleosts.- 2.1.3 Modes of Encoding Electrical Stimuli.- 2.1.4 Central Projections of Electroreceptive Afferents (Mormyridae, Gymnotiformes).- 2.2 Electric Organs.- 2.2.1 Structure and Function of Electric Organs.- 2.2.2 Neural Control of Electric Organs.- 2.3 The Electric System in the Aquatic Environment.- 2.3.1 Active Electrolocation.- 2.3.2 Electrocommunication: Spatial Aspects of Sending and Receiving Electric Organ Discharges.- 3. Species Diversity of Electric Organ Discharge Activity.- 3.1 Waveforms of Electric Organ Discharges.- 3.1.1 Mormyriformes.- 3.1.1.1 Mormyriform Pulse Species (Mormyridae).- 3.1.1.2 Mormyriform Wave Species (Gymnarchus).- 3.1.2 Gymnotiformes.- 3.1.2.1 Gymnotiform Pulse Species.- 3.1.2.2 Gymnotiform Wave Species.- 3.1.3 Siluriformes.- 3.2 Patterns of Spontaneous Discharge Rates.- 3.2.1 Mormyriformes.- 3.2.1.1 Mormyriform Pulse Species (Mormyridae).- 3.2.1.2 Mormyriform Wave Species (Gymnarchus).- 3.2.2 Gymnotiformes.- 3.2.2.1 Gymnotiform Pulse Species.- 3.2.2.2 Gymnotiform Wave Species.- 3.2.3 Siluriformes.- 3.3 Responses to Disturbances (or Food Stimuli).- 3.3.1 Mormyriformes.- 3.3.1.1 Mormyriform Pulse Species (Mormyridae).- 3.3.1.2 Mormyriform Wave Species (Gymnarchus).- 3.3.2 Gymnotiformes.- 3.3.2.1 Gymnotiform Pulse Species.- 3.3.2.2 Gymnotiform Wave Species.- 3.3.3 Siluriformes.- 4. Communicating with Electric Organ Discharges.- 4.1 Electrical and Motor Displays of Communicating Fish.- 4.1.1 Mormyriformes.- 4.1.1.1 Mormyriform Pulse Species (Mormyridae).- 4.1.1.2 Mormyriform Wave Species (Gymnarchus).- 4.1.2 Gymnotiformes.- 4.1.2.1 Gymnotiform Pulse Species.- 4.1.2.2 Gymnotiform Wave Species.- 4.2 Experimental Manipulation of the Electrocommunication System.- 4.2.1 Mormyriformes.- 4.2.1.1 Ethological Approach.- 4.2.1.2 Playback of EOD Interval Patterns.- 4.2.1.3 Species Recognition by EOD Interval Pattern (B. Kramer and H. Lücker).- 4.2.1.4 Discrimination of Inter-Pulse Intervals (B. Kramer and U. Heinrich).- 4.2.2 Gymnotiformes.- 4.2.2.1 Electrical Stimulation and Playback of EOD Patterns in Pulse Species.- 4.2.2.2 Electrical Stimulation and Playback of EODs in Wave Species.- Conclusion.- References.- Systematic Index.
£85.49
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Anleitung zur Erkennung, Prüfung und Wertbestimmung der gebräuchlichsten Chemikalien für den technischen, analytischen und pharmaceutischen Gebrauch
Table of ContentsA.- B.- C.- D.- E.- F.- G.- H.- I.- J.- K.- L.- M.- N.- O.- P.- R.- S.- T.- U.- V.- X.- Z.
£45.99
LAP Lambert Academic Publishing Lysozyme Purification from Chicken Egg White and Its Scale-Up Studies
£31.46
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG The Hot-Blooded Insects: Strategies and
Book Synopsis"From one man's persistent and elegant probing of the temperature biology of bees, we have been led to a deeper understanding of the whole biology of many insect taxa, and of their interactions with ecological and environmental stresses: all who work at the interfaces of physiology, ecology and behaviour have cause to be grateful, and all should certainly read this book." (Trends in Ecology & Evolution) "An outstanding source of information, and can be read with profit and satisfaction by the professional biologist and interested amateur alike." (Nature)Trade Review"From one man's persistent and elegant probing of the temperature biology of bees, we have been led to a deeper understanding of the whole biology of many insect taxa, and of their interactions with ecological and environmental stresses: all who work at the interfaces of physiology, ecology and behaviour have cause to be grateful, and all should certainly read this book." (Trends in Ecology & Evolution) "An outstanding source of information, and can be read with profit and satisfaction by the professional biologist and interested amateur alike." (Nature)Table of ContentsPrologue.- 1 Night-Flying Moths.- 2 Butterflies and Wings.- 3 Dragonflies Now and Then.- 4 Grasshoppers and Other Orthoptera.- 5 Beetles Large and Small.- 6 Bumblebees Out in the Cold.- 7 Tropical Bees.- 8 Hot-Headed Honeybees.- 9 The Tolerance of Ants.- 10 Wasps and the Heat of Battle.- 11 Flies of All Kinds.- 12 Sweating Cicadas.- 13 Warm Caterpillars and Hot Maggots.- 14 Fever.- 15 Cold Jumpers.- 16 Social Thermoregulation.- Summary.- References.- Acknowledgments.- Index of Authors Cited.- General Index.
£85.49
World Health Organization Lindane
£17.50
Springer Disulfiram and its Metabolite,
Book SynopsisThis book is aimed at those in the biomedical community that are interested in the therapeutic applications, pharmacology, biochemistry, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram (Antabuse®) regimens that allow alcoholics to achieve abstinence of many months' duration have made writing this book an exciting experience. At the same time the fact that the two drugs differ substantially in their pharmacological effects in spite of their easy interconvertibility has rendered the writing intellec tually challenging. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper ties. Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear. The drug is also a potent chelator of heavy metals and this has led to a number of clinical applications. As might be expected, it inhibits several important enzymes. Further, it is one of the most effective radioprotective agents; it also protects organisms against a variety of toxic agents.Trade Review...a well written, detailed publication on literally everything the reader would wish to know about disulfiram and its metabolite - British Journal of Psychiatry; This well written and carefully edited volume deserves the interest of toxicologists, pharmacologists, immunologists, biochemists and clinicians. Journal of Applied Toxicology; It is hoped that clinicians and behavioral scientists have read this book for their own education and also to appreciate the advances made in the biochemical pharmacology of DSSD and SSH. This book should capture the interest of medicinal chemists and pharmacologists who are engaged in research in cancer, immunomodulation, HIV, and heavy metal toxicity. Selected chapters are must reading for biomedical scientists pursuing alcoholism research. Journal of Medicinal ChemistryTable of ContentsIntroduction and scope of monograph. Relevant chemical and physical properties. Reactions of disulfiram and diethyldithiocarbamate with blood constituents. Assay methods for disulfiram and metabolites in biological materials. Metabolism of disulfiram and diethyldithiocarbamate. Pharmacokinetic aspects of the disposition of disulfiram and metabolites. Heavy metals: effects of diethyldithiocarbamate and disulfiram administration. Disulfiram and diethyldithiocarbamate as enzyme inhibitors. Inhibition of aldehyde dehydrogenase. The disulfiram-ethanol reaction. Disulfiram therapy of alcohol abuse. Various biological phenomena. Immunomodulatory actions of diethyldithiocarbamate. Clinical status of diethyldithiocarbamate as an immunostimulant. Modulation of various biological phenomena. Modulation of cancer chemotherapy. Toxicology. Bibliography. Index.
£44.99
Springer A Guide to Protein Isolation
Book SynopsisIt is a truism of science that the more fundamental the subject, the more universally applicable it is. Nevertheless, it is important to strike a level of “fundamentalness” appropriate to the task in hand. For -depth study of the mechanics of motor cars would tell one example, an in nothing about the dynamics of traffic. Traffic exists on a different “level” - it is dependent upon the existence of motor vehicles but the physics and mathematics of traffic can be adequately addressed by considering motor vehicles as mobile “blobs”,with no consideration of how they become mobile. To start a discourse on traffic with a consideration of the mechanics of motor vehicles would thus be inappropropriate. In writing this volume, I have wrestled with the question of the appropriate level at which to address the physics underlying many of the techniques used in protein isolation. I have tried to strike a level as would be used by a mechanic (with perhaps a slight leaning towards an engineer) - i.e. a practical level, offering appropriate insight but with minimal mathematics. Some people involved in biochemical research have a minimal grounding in chemistry and physics and so I have tried to keep it as simple as possible.Table of ContentsAcknowledgements. Preface. 1. An overview of protein isolation. 2. Assay, extraction and sub-cellular fractionation. 3. Concentration of the extract. 4. Chromatography. 5. Electrophoresis. 6. Immunological methods. Index.
£44.99
Elsevier Science Handbook of Cell Signaling
Book Synopsis
£280.50
Elsevier Science Publishing Co Inc Introduction to Biomedical Engineering
Book SynopsisOffers a comprehensive survey text for biomedical engineering courses. This book helps biomedical engineers to understand the range of topics such as basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomaterials science and tissue engineering; and medical and engineering ethics.Table of Contents1. Biomedical Engineering: A Historical Perspective 2. Moral and Ethical Issues 3. Anatomy and Physiology 4. Biomechanics 5. Biomaterials 6. Tissue Engineering 7. Compartmental Modeling 8. Biochemical Reactions and Enzyme Kinetics 9. Bioinstrumentation 10. Biomedical Sensors 11. Biosignal Processing 12. Bioelectric Phenomena 13. Physiological Modeling 14. Biomedical Transport Processes 15. Radiation Imaging 16. Medical Imaging 17. Biomedical Optics and Lasers
£97.50
Knopf Doubleday Publishing Group Avoid Boring People
a huge range and FREE tracked UK delivery on ALL orders.
£21.30
Taylor & Francis Ltd Environmental Stress and Cellular Response in
Book SynopsisWhile the subject of environmental stress in animals is broad, the available information is fragmentary and lacks an up-to-date overview and analysis. Environmental Stress and Cellular Response in Arthropods fills these knowledge gaps. Written by three experts from the same institution, the chapters have a consistency not often found in multi-authored or contributed books. The authors describe environmental stress in arthropods, specifically Drosophila and analyze the process in all its aspects, from biochemical mechanisms to effects on the whole organism. Incorporating new information that has become available in recent years, the authors explore hypotheses about the integrated response these systems often have. They explore topics ranging from disturbance of homeostasis, changes in metabolic processes, damage of cellular structures to acquired tolerance, effects on aging processes, and survival and cell death. By analyzing all these aspects in detail at the moleculaTable of ContentsBasal Signal Transduction Systems Involved in Stress Response. The Stress-protein System. The Oxidative Stress Response System. The Metallothionein System. The Mixed Function Oxygenase System. The Role of Cellular Response Systems in Developing Tolerance to Environmental Stress. The Effects of Environmental Stress on Aging and Cell Death. The Integrated Cellular Stress Defense System.
£161.50
Taylor & Francis Ltd The Taiwan Crisis a showcase of the global
Book SynopsisIn the 1950s, the residents of the southwestern coastal areas of Taiwan suffered greatly from Blackfoot disease (BFD) due to the consumption of arsenic-contaminated groundwater. Groundwater with high levels of arsenic in southwestern and northeastern Taiwan received much attention. After arsenic-safe tap water was utilized for drinking instead of groundwater in the 1970s, BFD cases decreased greatly. After 1990, no new BFD cases were reported, and as a consequence, BFD problems disregarded. However, arsenic is still present in the groundwater.This book will improve the knowledge and understanding of the occurrence and genesis of arsenic-rich groundwaters in Taiwan. It deals with constraints on the mobility of arsenic in groundwater, its uptake from soil and water by plants, arsenic-propagation through the food chain, human health impacts, and arsenic-removal technologies. Taiwan case experiences are described in this book and can be applied worldwide.This book is aTable of ContentsTaiwan and the Global Arsenic Problem; Geological Controls of Arsenic Concentrations in Ground- and Surface; Waters History of Blackfoot Disease; Arsenic in Artesian Well Water; Non-Vascular Health Effects of Arsenic in Drinking Water in Taiwan. Arsenic Sources, Occurrences and Mobility in Surface Water, Groundwater and Sediments; Arsenic in Soils and Plants; Potential Threat of the Use of Arsenic Contaminated Water in Aquaculture; Current Solutions to Arsenic Contaminated Water;
£99.75
Elsevier Science Comprehensive Chemometrics
Book Synopsis
£2,700.00
Taylor & Francis Inc Mechanism in Protein Chemistry
Book SynopsisDescribes proteins'' physical and chemical nature and how their molecular structures can be determined experimentally. Intended for upper level undergraduate and graduate students with a background in chemistry or biochemistry.Table of Contents1. Reaction Mechanisms 2. Coenzymes 3. Binding of Substrates to the Active Site 4. Transfer of Protons 5. Intermediates in Enzymatic Reactions 6. Conformational Changes
£175.75
Taylor & Francis Inc Red Blood Cell Substitutes
Book SynopsisDiscusses regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. This text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations.Table of ContentsUtilization - economic and regulatory issues: the impact of blood substitutes on blood banking world wide; potential use of red blood cells substitutes within the military; blood substitutes - unique regulatory aspects. Fundamental principles of oxygen transport : oxygen transport, oxygen carriers, and the transfusion trigger; microcirculatory consequences of blood substitutes with haemoglobin solutions; efficacy of perfluorocarbon-based emulsion as a temporary oxygen carrier; pathophysiology of oxygen utilization in haemorrhagic shock - studies with human recombinant haemoglobin. Interactions with organ systems: immunological alterations following haemorrhagic shock - considerations for resuscitation with blood substitutes; the effect of haemoglobin-based substitutes on kidney function; interactions of haemoglobin with the central nervous system. Interactions with molecular species: interactions between haemoglobin and bacterial endotoxin In Vitro and In Vivo. Alternative strategies and indications: encapsulation of haemoglobin in liposomes; the use of blood substitutes in tumour therapy; human haemoglobin derived from transgenic swine - a starting material for 'blood substitute' formulations. Clinical development: OptroTM (recombinant human haemoglobin) - a therapeutic for the delivery of oxygen and the restoration of blood volume in the treatment of acute blood loss in trauma and surgery; production, characterization, and clinical evaluation of hemolinkTM on o-raffinose cross-linked haemoglobin-based blood substitute; hemassistTM - development and clinical profile; the clinical development of human polymerized haemoglobin; oxypureTM - development of polymerized bovine haemoglobin; febluobronTM - development of an oxygen carrying perfluobronTM - development of an oxygen carrying perfluorocarbon. Future directions: future perspective of red cells substitutes.
£285.00
Taylor & Francis Inc Oxidative Stress Inflammation and Health
Book SynopsisFocusing on the redox regulation of cell signaling responsible for oxidative stress and inflammatory tissue damage, this reference presents a comprehensive overview of research on the intracellular events mediating or preventing oxidative stress and pro-inflammatory processes induced by endogenous and xenobiotic factors.Table of ContentsOxidants and Antioxidants: Mechanism of Action and Regulation of Gene Expression by Bio?avonoids. Transcriptional Regulation of Cellular Antioxidant Defense Mechanisms. Redox Regulation of In?ammatory Tissue Damage by Thioredoxin. Regulation of NF-kB-Driven In?ammatory Genes by Phytoestrogens. Nuclear Factor-kB as Target for Chemoprevention. Heme Oxygenase-1: An Emerging Major Cellular Defense Against Cigarette Smoke-Induced Oxidative Stress and Cytotoxicity. Biphasic Induction of HO-1 in Macrophages Treated with Lipopolysaccharide: Role of HO-1 Induction in Cell Survival from Oxidative Stress. The Role of Ga12 Proteins in the PKC and JNK-Dependent Induction of NOS by Thrombin. Actions of 8-Hydroxyguanine in DNA. Role of Oxidative Stress in Hypercholesterolemia-Induced In?ammation. Oxidative Stress in Rheumatoid Arthritis. Roles of Carbon Monoxide and Nitric Oxide in Liver Damage. Role of Oxidative Stress and In?ammatory Response in Smokers and Chronic Obstructive Pulmonary Disease. Association of Chronic In?ammation with Carcinogenesis: Implications of Anti-In?ammatory Strategies for Cancer Prevention. Molecular In?ammation as an Underlying Mechanism of Aging: The Anti-in?ammatory Action of Calorie Restriction. Oxidative Stress in Mitochondria: The Involvement in Neurodegenerative Diseases. Implications of In?ammatory Stress in Alzheimer's Disease. Biomarkers for Evaluating Antioxidant Effects. Antioxidant and Neuroprotective Potentials. Resveratrol-A Unique Polyphenolic Antioxidant Present in Grape Skins and Red Wine-Is a Preventive Medicine Against a Variety of Degenerative Diseases. Molecular Mechanisms of Prevention Against Allergic Rhinitis by Aller-7, A Novel Polyherbal Formulation. Antioxidant Character of Selenium and Its Survival Signals by Activation of PI3-K/Akt Pathways. Neuroprotection by Rasagiline and Related Propargylamines Is Mediated by Suppression of Mitochondrial Death Signal and Induction of Antiapoptotic Genes. Index.
£237.50
Taylor & Francis Inc Protein Purification Process Engineering 18
Book SynopsisOffers coverage of the development of protein purification processes for large-scale commercial operations, and addresses process development, scale-up, applications and mathematical descriptions. Technologies currently used at the commercial scale are covered in depth.Trade Review"I recommend this thorough and valuable reference. "---BioPharm ". . .strongly recommended. "---European Journal of Pharmaceutics and BiopharmaceuticsTable of Contents"Organization and Strategy, Roger G. Harrison Analytical Considerations in the Development of Protein Purification Processes, Vincent Anicetti and William S. Hancock Cell Breakage, Cady R. Engler Crossflow Membrane Filtration, Zhi-Guo Su and Clark K. Cotton Liquid-Liquid Extraction, Dennis J. Kubek Differential Precipitation of Proteins: Science and Technology, Fred Rothstein Conventional Chromatography, John M. Simpson Biospecific Affinity Chromatography, Nikos K. Harakas Freeze Drying: A Practical Overview, Larry A. Gatlin and Steven L. Nail "
£285.00
Taylor & Francis Inc Directory of Therapeutic Enzymes
Book SynopsisCarefully crafted to provide tightly focused and authoritative information, the Directory of Therapeutic Enzymes covers all approved therapeutic enzymes currently used in medicine. Written mainly by industry experts, the book includes information sourced directly from the company that developed or manufactured the product. It explores major development issues, from manufacturing and marketing to delivery of the finished product.Chapter 1 reviews applied enzymology while chapter 2 delineates theory and applications. Between them, the first two chapters set the appropriate backdrop for the remaining chapters, which focus on actual enzyme products that have gained regulatory approval for general medical use. The chapter authors discuss the biochemistry of the enzymes, the reactions they catalyze, how they are produced or manufactured, and their medical applications. The book highlights the many applications of approved therapeutic enzymes, including use in the treatment of blood-clotting disorders, certain cancers, and a variety of genetic disorders. Illustrated with tables and figures that support the text, the book is a single source of in-depth technical information.Table of ContentsApplied Enzymology, An Introduction. Enzyme Engineering. Tissue Plasminogen Activator (tPA). Urokinase. (Activated) Protein C. Ancrod. Nuclease (Dnase). Glucocerebrosidase. L-Galactosidase. Urate Oxidase. Asparaginase. Factor Ixa. Superoxide Dismutase. Debriding and Anti-Inflammatory Agents. Enzymes as Digestive Aids.
£237.50
Taylor & Francis Inc Molecular and Cellular Methods in Developmental
Book SynopsisThis new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.Table of ContentsPart I. Molecular Techniques -- Chapter 1. Molecular Techniques for Developmental Toxicology: An Introduction/George P Daston -- Chapter 2. Visualization of Gene Expression Patterns by In Situ Hybridization/ Urs Albrecht, Gregor Eichele, Jill A. Helms, and Hui-Chen Lu -- Chapter 3. Utilizing Transgenic Mice to Study Gene Regulation and Function/Michael R. Blackburn and Rodney E. Kellems -- Chapter 4. The Use of Antisense Oligonucleotide Technology and Mouse Whole-Embryo Culture to Study Gene Function During Organogenesis/Linda Foerst Potts and T W. Sadler -- Chapter 5. Nucleic Acid Amplification Technologies/Richard H. Finnell, Scott J. Vacha, and Scott A. Mackler -- Part II. Protein Identification -- Chapter 6. Fundamentals of Protein Identification: Biochemical and Immunological Analysis of Developmentally Altered Protein Expression/Gerald B. Grunwald -- Chapter 7. Immunohistochemistry/Philip E. Mirkes and Sally A Little -- Part III. Cellular Techniques -- Chapter 8. Cellular Techniques for Teratological Cell Death/Thomas B. Knudsen -- Chapter 9. Applications of Flow Cytometry in Developmental and Reproductive Toxicology/Kenneth H. Elstein and Robert M. Zucker -- Chapter 10. Modern Techniques for Cell Labeling in Avian and Murine Embryos/Diana K. Darnell and Gary C. Schoenwolf -- Index.
£114.00
Taylor & Francis Inc Immunotoxicology and Immunopharmacology
Book SynopsisContinuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.Table of ContentsImmunotoxicology and Hazard Identification. Immunopharmacology and Immunotoxicology of Therapeutics. Environmental Agents. Immunotoxicology in the Lung. Developmental Immunotoxicity. Wildlife Immunotoxicology. Autoimmunity and Autoimmune Diseases. Neuroimmunology. Allergy and Hypersensitivity.
£166.25
Taylor & Francis Inc Protein Nutrition and Mineral Absorption
Book SynopsisThis volume presents information regarding the mechanisms of protein absorption under normal and pathologic conditions, in addition to reviewing changes that occur at various stages of life. General modifiers of intestinal absorption, such as the processing of foods, the nutritional status of the individual, and disease, are explored with reference to both proteins and minerals. Inorganic macronutrients, namely calcium, magnesium and phosphorus, are discussed in relation to protein ingestion. The book also explores the concept of essential trace elements (e.g., iron, zinc, copper, and iodine) and their link to protein sufficiency. The relationship of ultratrace elements with the content of proteins in food is examined, and the book offers a fresh view of the role of certain elements, particularly zinc, on the conformation of proteins linked to DNA, hormone receptors, and gene products. Protein Nutrition and Mineral Absorption is packed with 2,300 references, 100 figures and graphs, pluTrade Review"This is a wonderful volume. It will be of great use to all of us involved in clinical nutrition and will serve as an excellent starting point for anyone wishing an introduction to this important field."-Journal of Parenteral and Enteral NutritionTable of ContentsMECHANISMS OF PROTEIN ABSORPTION. HISTORICAL PERSPECTIVE. AMINO ACID VS. OLIGOPEPTIDE ABSORPTION. SMALL PEPTIDES AS THE MAJOR SUBSTRATES OF PROTEIN ABSORPTION. ABSORPTION OF INTACT PROTEINS. REFERENCES. EFFECT OF NUTRITIONAL STATUS AND DISEASE ON PROTEIN ABSORPTION. INTRODUCTION. EFFECT OF PROTEIN DEFICIENCY ON AMINO ACID AND OLIGOPEPTIDE ABSORPTION. DIETARY AND METABOLIC REGULATION OF AMINO ACID ABSORPTION. ABSORPTION OF INTACT PROTEINS IN NUTRITIONAL DEPRIVATION. EFFECT OF MATERNAL PROTEIN RESTRICTION ON NEONATAL PROTEIN ABSORPTION. ABSORPTION OF PROTEIN IN ACQUIRED DISEASE. General Considerations. Celiac Disease (Sprue). Renal Disease. ABSORPTION OF PROTEIN IN CONGENITAL DISEASE. General Considerations. Cystinuria. Familial Protein Intolerance. Hyperdibasic Aminoaciduria. Neutral Amino Acid Malabsorption Syndromes. Iminoglycinuria. Lowe's Syndrome. Congenital Agammaglobulinemia. Peptiduria Associated with Aminopeptidase-P Deficiency. REFERENCES. DEVELOPMENTAL FACTORS IN PROTEIN AND MINERAL ABSORPTION. INTRODUCTION. ONTOGENY OF THE GASTROINTESTINAL TRACT. Morphology. Development of the Gastrointestinal Mucosal Barrier. Membrane Composition and Rheologic Properties. DEVELOPMENT OF PROTEIN ABSORPTION MECHANISMS. Enzymatic Ontogeny. The Mammalian Intestine. Ontogeny of Human Protein Absorptive Mechanisms. Ontogeny of Amino Acid and Dipeptide Absorptive Mechanisms. Hormonal Control of Enzymatic Maturation. Role of Diet in the Development of Intestinal Absorptive Function. ONTOGENY OF MINERAL ABSORPTION. General Considerations. Calcium, Magnesium, Phosphorus. Iron. Zinc and Copper. Other Elements. PROTEIN AND MINERAL ABSORPTION LATE IN LIFE. Protein. Minerals. REFERENCES. EFFECT OF FOOD SOURCES AND PROCESSING ON PROTEIN AND MINERAL ABSORPTION. GENERAL. IMPORTANCE OF FOOD SOURCES. PHYSICAL TREATMENTS. Milling, Polishing, and Other Mechanical Processes. Heating. Cooking. Dehydration. Water Extraction. Leaching. Washing. Freezing/Thawing. Osmotic Alteration. Storage (Aging). Packaging. Emulsification, Homogenization, Gellification. CHEMICAL TREATMENTS. Oxidation, Reduction. Schiff Base Formation. Maillard Reactions. Browning. Acidification. Alkalinization. Sequestration. Natural Chelating Agents. Chemical Processing with Macro-Additives: Salt, Curing. REFERENCES. CALCIUM, MAGNESIUM, AND PHOSPHORUS ABSORPTION, NUTRITIONAL STATUS AND EFFECT OF PROTEINS. NUTRITIONAL ASPECTS OF CALCIUM ABSORPTION. Calcium in Foods and Its Bioavailability. Mucosal Receptors at the Brush Border Mucosa. Transcellular Transport of Calcium. Effects of Protein Nutrition on Calcium Metabolic Balance. Protein-Calcium-Phosphorus Interactions. Osteoporosis. Overview of Calcium-Protein-Phosphate Interactions. NUTRITIONAL ASPECTS AND MECHANISMS OF MAGNESIUM ABSORPTION. Magnesium Requirements and Absorption. Protein-Energy Malnutrition and Magnesium Sufficiency. Studies Relating Protein and Magnesium Absorption and Sufficiency. Magnesium and Calcium Imbalances in Metabolic Disease. PHOSPHATE ABSORPTION, CATION BALANCE REGULATION, AND PROTEIN INTAKE. Dietary Phosphate and Intestinal Absorptive Mechanisms. The Phosphate-Calcium-Protein Connection. REFERENCES. NUTRITIONAL FACTORS, PROTEINS, AND THE ABSORPTION OF IRON AND COBALT. IRON CHEMISTRY AND DETERMINANTS OF THE SOLUBILITY OF THE ELEMENT. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF IRON. Luminal Factors. Mucosal Factors. Corporeal Factors. PROTEIN DERIVED PRODUCTS AND IRON ABSORPTION. Historical Background. Animal Proteins. Amino Acids. Peptides. PROTEIN NUTRITIONAL STATUS AND INTERACTIONS WITH IRON ABSORPTION. DEFECTS IN THE INTESTINAL ABSORPTION OF IRON. Idiopathic Hemochromatosis. Iron Malabsorption. PROTEIN AND NUTRITIONAL FACTORS IN THE ABSORPTION OF COBALT. Cobalt as a Possible Essential Trace Element. Essentiality of Cobalt and Cobalamines. Absorption of Vitamin B12 and of Cobalt. Attempts at Pharmacologic Uses of Cobalt. Toxicity of Cobalt. REFERENCES. ZINC ABSORPTION AND SUFFICIENCY AS AFFECTED BY PROTEIN AND OTHER NUTRIENTS. SIGNIFICANCE OF ZINC AS AN ESSENTIAL NUTRIENT. Requirements of Zinc by Vegetables and in the Animal Kingdom. Role of Zinc in Biological Processes. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF ZINC. Luminal and Dietary Factors. Mucosal Factors. Corporeal Factors. PROTEIN-DERIVED PRODUCTS AND ZINC ABSORPTION. Introduction. Amino Acids. Peptides. Proteins. ZINC MALABSORPTION. Congenital Conditions. Acquired Malabsorption. REFERENCES. COPPER ABSORPTION AND BODY DISTRIBUTION: ROLE OF PROTEIN AND OTHER NUTRIENTS. ROLE OF COPPER IN BIOLOGICAL SYSTEMS. Biological Roles of Copper. MECHANISMS FOR THE LUMINAL REMOVAL OF COPPER AND TISSUE DISTRIBUTION. Transport Across Membranes. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF COPPER. Ecological and Geographical Considerations. Luminal Factors. Mucosal Factors. Somatic Factors. PROTEIN-DERIVED PRODUCTS AND COPPER ABSORPTION. Amino Acid Participation in Copper Transport Mechanisms. Effect of Proteins and Protein Breakdown Products. INTERACTION OF OTHER ELEMENTS ON COPPER ABSORPTION. Inhibition of Copper Absorption by Zinc. Copper-Zinc Imbalance, Cholesterol, and Chronic Degenerative Diseases. GENETIC DISEASES OF COPPER ABSORPTION AND HOMEOSTASIS. Defects in Copper Uptake, Distribution, and Excretion. REFERENCES. NUTRITIONAL, ENVIRONMENTAL, AND PHYSIOLOGIC FACTORS AFFECTING SELENIUM, CHROMIUM, AND NICKEL SUFFICIENCY. SELENIUM. Selenium as a Nutrient and as a Potential Toxic Agent. FACTORS INVOLVED IN THE INTESTINAL ABSORPTION OF SELENIUM. SELENIUM ADSORPTION FROM HIGH PORTEIN PRODUCTS. CHROMIUM. Chromium Chemistry and the Evidence of Nutritional Essentiality. Chromium Absorption and Tissue Distribution. Biological Roles of Chromium. Chromium Nutrition in Protein-Energy Malnutrition, Stress, and TPN. NICKEL. REFERENCES. NUTRITIONAL STATUS AND THE EFFECT OF PROTEIN AND OTHER FOODSTUFFS ON THE ABSORPTION OF MANGANESE, MOLYBDENUM, AND VANADIUM. MANGANESE. Role of Manganese in Biological Processes. Nutritional Requirements in Man and Animals. Manganese Deficiency and Toxicity. Factors Involved in the Intestinal Absorption of Manganese. Protein-Derived Products and Manganese Absorption. MOLYBDENUM. Occurrence of Molybdenum in Nature. Its Passage Through the Food Chain. Role of Molybdenum in Biological Processes. Nutritional Requirements in Man and Animals. Molybdenum Deficiency and Toxicity. Factors Involved in the Intestinal Absorption of Molybdenum. Protein-Derived Products and Molybdenum Absorption. VANADIUM. Role of Vanadium in Biological Processes. Intestinal Absorption of Vanadium. REFERENCES. THE ABSORPTION OF ARSENIC, BORON, SILICON, ALUMINUM, TIN, IODINE, AND FLUORINE: INTERACTIONS WITH PROTEINS AND OTHER NUTRIENTS. NUTRIENT VARIABLES AND THE ABSORPTION OF ARSENIC. Man and Its Relationship with Arsenic. Presentation of the Element in Nature. Arsenic as an Essential Trace Element. Role of Arsenic in Biological Processes. Arsenic in the Food Chain. Absorption of Arsenic. Metabolism of Protein and Amino Acids and Arsenic Nutrition. BIOLOGICAL AND NUTRITIONAL FACTORS IN BORON SUFFICIENCY. Boron in Nature and Its Role in Biological Processes. Boron in the Food Chain and Metabolic Fate of Ingested Boron. Metabolic Effects of Boron. Interaction with Vitamin D and Other Minerals. Role of Certain Amino Acids. SILICON AS A NUTRIENT. INTERACTIONS WITH PROTEINS AND OTHER DIETARY PRODUCTS. Silicon in Nature and in the Human Food Chain. Biological Role of Silicon. Interaction of Silicon with Other Nutrients. NUTRITIONAL AND TOXIC ASPECTS OF ALUMINUM IN THE DIET AND THE ENVIRONMENT. Aluminum in Nature and in the Food Chain. Intestinal Absorption of Aluminum. Toxicity of Aluminum. Factors Affecting the Oral Absorption of Aluminum. TIN IN THE DIET AND THE ENVIRONMENT. ITS INTERACTION WITH OTHER NUTRIENTS. Tin in Nature and in the Food Chain. The Question of Tin Essentiality. Intestinal Absorption of Tin. Interaction of Tin with Other Nutrients. PROTEIN AND OTHER NUTRITIONAL FACTORS IN THE METABOLISM AND ABSORPTION OF IODINE. Iodine in Nature. Chemical Characteristics. Role and Metabolism of Iodine. Essentiality of Iodine. Requirements. Nutritional Deficit and Toxicity. Iodine in Foods. Relation with Nutritional Status and Protein Sufficiency. NUTRITIONAL FACTORS IN THE ABSORPTION OF FLUORINE. Role of Fluorine Compounds in Calcified Tissue and Dental Integrity. Possible Essentiality of Fluorine. Metabolic Effects. Fluorine in the Diet. Absorption and Excretion. Relationship of Fluorine with Macronutrients. Interactions with Other Minerals. REFERENCES. "FINGERS", "KNUCKLES", "HANDS", "FISTS", "SIGNATURES", AND OTHER STRUCTURAL MOTIFS IN PROTEINS INVOLVING ZINC AND OTHER ESSENTIAL ELEMENTS. ZINC "FINGERS" AND THEIR ROLE IN BIOLOGICALLY ACTIVE PROTEINS. Transcription Factors. Zinc Fingers in Hormone Receptors. Finger Loops and Oncogenes. BINDING OF ZINC TO OTHER PROTEINS. DEVELOPMENT OF CATALYTIC PROPERTIES. DIFFERENT "SIGNATURES". COPPER "FISTS", METALLOTHIONEINS, AND GENE EXPRESSION. PROTEIN STRUCTURE DESIGN: "HELICES", "HANDS", "GREEK KEYS", "b-BARRELS", "SHEETS", "COILS", AND "ZIPPERS". REFERENCES. OVERVIEW.
£427.50
Taylor & Francis Inc Xenobiotic Metabolism and Disposition
Book SynopsisThis publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.Table of ContentsSECTION 1: INTRODUCTION, Chapter 1 The Rationale for and Timing of Drug Metabolism Studies, SECTION 2: IN VIVO BIOLOGICAL STUDIES, Chapter 2 Aims, Chapter 3 Balance Studies, Chapter 4 Whole Body Autoradiography, Chapter 5 Surgical Techniques Used in Disposition and Metabolism Studies, Chapter 6 Afterword, SECTION 3: EXTRAPOLATION OF DATA AND STUDIES IN MAN, Chapter 7 Studies in Man with Potential Therapeutic Agents, Chapter 8 Pharmacokinetics and Its Application to Drug Development, SECTION 4: METABOLITE IDENTIFICATION AND IN VITRO STUDIES, Chapter 9 Analytical Procedures for Metabolites: Metabolite Profiling and the Isolation and Identification of Metabolitesm, Chapter 10 In Vitro Studies on Metabolism, Chapter 11 Biochemical Studies on Induction, Inhibition, and Activation, Index
£308.75
Taylor & Francis Inc Proteins and Nonprotein Nitrogen in Human Milk
Book SynopsisFor the first time, an entire publication has been dedicated to providing a critical review of the identification and analysis of the milk specific proteins such as lactalbumin, lactoferrin and casein; the non-milk specific proteins such as plasma and membrane proteins; and the minor nitrogen-containing components such as enzymes, hormones, and growth factors. Biological roles, whether nutritional, endocrinological or immunological, of the specific nitrogen compounds in mammary milk production and/or growth and development of the breast-fed infant are also presented. Identification of the molecular weight compounds that have led to questions about their function in milk and their inclusion in modern infant formulas is thoroughly discussed and of great value to scientists in sub-specialties of biochemistry, nutrition, physiology and immunology, as well as to pediatric practitioners with primary interests in the infant food industry, academia, or clinical nutrition. The thoroughness oTable of ContentsSection A: Overview, Chapter 1 Overview: The Biochemistry of Nitrogen-Containing Compounds in Human Milk and Their Physiological Significance, Section B: Proteins in Human Milk, Chapter 2 Casein Micelles and Casein Subunits in Human Milk, Chapter 3 Whey Proteins in Human Milk, Chapter 4 Immunoglobulins in Human Milk, Chapter 5 Peptide Hormones and Hormone-Like Substances in Milk, Chapter 6 Enzymes in Human Milk, Chapter 7 Growth Factors in Human Milk: Sources and Potential Physiological Roles, Chapter 8 Fat Globule Proteins, Section C: Non-Protein Nitrogen in Human Milk, Chapter 9 Non-Protein Nitrogen Components in Human Milk: Biochemistry and Potential Functional Role, Section D: Physiological Significance of the Nitrogen Composition of Human Milk, Chapter 10 Protein Quantity and Whey-Casein Ratio in Infant Formulas, Chapter 11 Is Taurine an Essential Nutrient for Neonates?, Chapter 12 Excretion of Human Milk Proteins by Term and Premature Infants, Chapter 13 Amino Acid Metabolism in Human Milk-Fed and Formula-Fed Term Infants, Chapter 14 Amino Acid Metabolism and Requirements of the Premature Infant: Is Human Milk the “Gold Standard”?, Chapter 15 Nonimmunoglobulin Components in Human Milk — Candidates for Prophylaxis Against Infantile Infections, Chapter 16 Milk Lipases and In Vivo Lipolysis, Index
£475.00
Taylor & Francis Inc Toxicants of Plant Origin
Book SynopsisThis comprehensive treatise offers an in-depth discussion of natural toxicants in plants, emphasizing their effects as defenses against herbivory. Coevolution of plants and her-bivores are covered with a detailed treatment of toxicant metabolism and systemic effects in mammalian tissues. Con-sideration of the economic importance of plant toxins, modi-fication by plant breeding, management of toxico-sis, and toxicant problems in various geographic areas are in-cluded. Each volume offers an extensive description of chemistry, biosynthesis, analysis, distribution in plants, metabolism in mam-mals and insects, and practical problems in humans and livestock.Table of ContentsVOLUME I: ALKALOIDS Pyrrolizidine Al-kaloid Toxicity and Metabolism in Laboratory Animals and Live-stock. Metabolism of Pyrrolizidine Alkaloids. Human Health Impli-cations of Pyrrolizidine Alkaloids and Herbs Containing Them. Nicotiana Alkaloids. Piperidine Al-kaloids of Poison Hemlock (Conium maculatum). Quinolizidine Alkaloids in Range and Grain Lupins. Indole Alkaloids from Phalaris and Other Gramineae. Solanum Glycoalka-loids. Swain-sonine: A Toxic Indolizidine Alkaloid. Slaframine: Occur-rence, Chemistry, and Physiological Activity. Toxic Alka-loids Associated with Tall Fescue Toxicosis. Toxicology of Diterpenoid Alkaloids in Rangeland Larkspur (Delphinium spp.). Index. c. 336 pp., 7x10, due July 1989, ISBN-0-8493-6990-8.
£570.00
Taylor & Francis Ltd (Sales) Dermal and Ocular Toxicology Fundamentals and Methods
a huge range and FREE tracked UK delivery on ALL orders.
£315.00
Taylor & Francis Inc Ecosystem Responses to Mercury Contamination
Book SynopsisAs rising levels of mercury in the environment pose an increasing threat of toxicity to humans and wildlife, several laws already call for industries to reduce mercury emissions at the source. Ecosystem Responses to Mercury Contamination: Indicators of Change outlines the infrastructure and methods needed to measure, monitor, and regulate the concentration of mercury present in the environment. This book draws on the knowledge of forty international experts in the fields of atmospheric transport and deposition, mercury cycling in terrestrial and aquatic ecosystems, and mercury bioaccumulation in aquatic foodwebs and wildlife. The authors propose a set of indicators to use as a measure of changing mercury concentrations in the environment. Next, they recommend a monitoring strategy and offer guidance for determining systematic changes in concentration. Then the authors examine additional monitoring strategies to relate observed changes in concentration to regulatory controls onTable of ContentsIntroduction. Airsheds and watersheds. Monitoring and evaluating trends in sediment and water indicators. Monitoring and evaluating trends in methylmercury accumulation in aquatic biota. Wildlife indicators. An integrated framework for ecological mercury assessments.
£175.75
Taylor & Francis Ltd Engineering Tools for Environmental Risk
Book SynopsisThis is the third volume of the five-volume book series âœEngineering Tools for Environmental Risk Managementâ. The book series deals with the following topics:â Environmental deterioration and pollution, management of environmental problemsâ Environmental toxicology â a tool for managing chemical substances and contaminated environmentâ Assessment and monitoring tools, risk assessmentâ Risk reduction measures and technologiesâ Case studies for demonstration of the application of engineering toolsThe authors aim to describe interactions and options in risk management by providing a broad scientific overview of the environment, its human uses and the associated local, regional and global environmental problems; interpreting the holistic approach used in solving environmental protection issues; striking a balance between natureâs needs and engineering capabilities; understanding interactions between regulation, management and engineering; obtaining informTable of ContentsIntegrated and efficient characteriaation of contaminated sitesMonitoring and early warning in environmental managementIn situ and real-time measurements in water monitoringIn situ and real-time measurements for effective soil and contaminated site managementDynamic site characterization for brownfield risk managementEnvironmental geochemistry modeling: Methods and applicationsPotential of cyclodextrins in risk assessment and monitoring of organic contaminants
£147.25
Taylor & Francis Ltd The Inhibitor Index
Book SynopsisMetabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers. Trade Review"Purich has compiled this handy reference tool listing approximately 7,800 biologically significant molecules that inhibit the action of enzymes or block cellular receptors...The list of targets enables laboratory researchers to choose the most specific and selective inhibitors or blockers for their experiments, and to remain alert to off-target effects. This unique desk reference will be useful for advanced undergraduate students, graduate students, and researchers devising laboratory research in cellular biochemistry and new drug development."-CHOICE, February 2018 Vol. 55 No. 6Table of ContentsNo TOC, it is an alphabetical listing of compounds.
£204.25
Macmillan Learning Lehninger Biochemistry Core Concepts and
Book Synopsis
£71.24
Taylor & Francis Inc Genomic Approaches for CrossSpecies Extrapolation
Book SynopsisThe latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from the experience of thirty-five scientists and professionals from diverse fields including environmental toxicology and chemistry, biomedical toxicology, molecular biology, genetics, physiology, bioinformatics, computer science, and statistics. The book introduces genomic, transcriptomic, proteomic, and metabolomic technologies. It describes the advantages and challenges associated with these approaches compared to traditional methodologies, particularly from the perspective of cross-species extrapolation within human and environmental toxicology, and explores solutions that will facilitate the incorporation of these technologies into Table of Contents"Omic" Approaches in the Context of Environmental Toxicology. Selection of Surrogate Animal Species for Comparative Toxicogenomics. Species Differences in Response to Toxic Substances: Shared Pathways of Toxicity. Bioinformatic Approaches and Computational Models for Data Integration and Cross-Species Extrapolation in the Post-Genomic Era. The Extension of Molecular and Computational Information to Risk Assessment and Regulatory Decision-Making.
£137.75
Taylor & Francis Inc Veterinary Medicines in the Environment
Book SynopsisExamine the Current State of the ScienceSurface water sampling programs across the globe have shown the presence of many different classes of medicines. The potential risks associated with the release of these medicines into the environment have become an increasingly important issue for environmental regulators. Effects of Veterinary Medicines in the Environment examines the current state of the science in evaluating the potential risks of veterinary medicines to aquatic and terrestrial ecosystems.International Panel Provide Guidance The book brings together more than 30 experts, from eight countries, with expertise in risk assessment, environmental toxicology and chemistry, and environmental policy and regulation. These experts provide guidance, based on standard risk assessment approaches, on how to assess the environmental effects of veterinary medicines. The text discusses pathTable of ContentsIntroduction. Use of Veterinary Medicines in the Environment. Environmental Risk Assessment and Management of Veterinary Medicines. Exposure Assessment of Veterinary Medicines in Aquatic Systems. Assessing the Aquatic Hazards of Veterinary Medicines. Exposure Assessment of Veterinary Medicines in Terrestrial Systems. Assessing the Effects of Veterinary Medicines on the Terrestrial Environment. Workshop Conclusions and Recommendations. Index.
£142.50
Taylor & Francis Inc Chemical Genomics and Proteomics
Book SynopsisSince the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice, which utilize the concepts of chemical genomics.The text provides an overview of the strategies and methodologies of chemical genomics, focusing on emerging technologies and recent applications in the areas of combination chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the development and application of novel analytical methods used in lTrade ReviewPraise for the First Edition"I thoroughly enjoyed this book and have already had to retrieve it from my PhD students who are anxious to read it ...make sure your library has a copy!"—Journal of Chemical Technology and Biotechnology, Vol. 80, Issue 8, August 2005"[This book] is the first book dedicated solely to chemical genomics. It presents the most important research and developments in chemical genomics … The plentiful tables and figures are well-designed and effectively support the content. … highly recommended for academic and special libraries with relevant programs, and for research scientists in the field."—E-StreamsTable of ContentsUtilizing small molecules in chemical genomics: Toward high-throughput approaches. Development and application of novel analytical methods in lipidomics. From chemical genomics to chemical proteomics: The power of microarray technology. Genomic and proteomic biomarkers in the drug R&D process. Quo vadis biomedical sciences in the omics era: Toward computational biology and medicine. Novel chemogenomic approaches to drug design.
£175.75
