Respiratory medicine Books

Book SynopsisTrade Review"In this defining ethnography of China's public health system and its complex relation to epidemics, Katherine Mason brilliantly describes health professionals, their struggles to be effective and ethical, the barriers they face, and how they animate the Chinese public health system as a lived reality. Infectious Change is an impressive contribution to both China studies and to medical anthropology!" -- Arthur Kleinman, Director * Harvard Asia Center *"Meticulously crafted, Infectious Change draws readers into the world of Chinese public health after SARS. Mason documents fundamentally different approaches to epidemic control among global, state, and local practitioners, including management of migratory populations, data collection, and ethics, arguing that global directives often stymie local efforts. This book elucidates why epidemic prevention everywhere must draw on local knowledge and practices." -- Margaret Lock * author of The Alzheimer Conundrum *"Infectious Change brings us for the first time before a hitherto unacknowledged consequence of the 2009 H1N1 crisis, and, at that, in one of the most epidemiologically critical regions of the globe today. It is this invaluable insight that should hold the attention not only of medical anthropologists but also of the wider global health community." -- Christos Lynteris * Medical Anthropology Quarterly *"This is an excellent, thought-provoking book, which will appeal to those with interests in contemporary China, medical anthropology, and histories of health and disease. It yields insights that will illuminate broader debates, such as those that pivot on the challenges inherent in promoting the "global" as a category in health." -- Robert Peckham * Bulletin of the History of Medicine *"Katherine Mason's book is an important contribution to the fields of Chinese studies and anthropology, joining a recent spate of excellent studies using the methods of anthropology to look at the intersections of public health, cultural practices and politics in China...Mason's book reminds us that implementing public health policy is never only about what is technically correct. It is about the cultural values and practices that govern relationships. It is also about understanding the power dynamics of the political system and generating the political will to construct an enabling environment and accountability mechanism to achieve it. In China, the tensions between centre and local are rarely resolved in favour of local and when new criteria for professional advancement are introduced, it results in the type of dysfunction so masterfully described by Mason." -- Joan Kaufman * China Quarterly *"In Infectious Change, Katherine A. Mason provides a captivating analysis of public health in China in the wake of SARS...Infectious Change is an insightful work that would be of interest to scholars of China and global health practitioners while also being accessible to a general academic reader. For China scholars, Mason makes a major contribution to the literature on public health." -- Emilio Dirlikov * Anthropological Quarterly *"Infectious Change presents a rich ethnographic account of how the Tianmai CDC works, how it would like to transform itself, and the barriers to doing so. It will make an excellent addition to courses on the anthropology of China or of global health because of the clarity of its ethnographic account and also because of the questions it opens up."––Elanah Uretsky, Asian MedicinTable of ContentsContents and Abstracts1Introduction chapter abstractThis chapter situates the reader in time and space and lays out the main arguments of the book. The author provides an overview of the recent history of public health in China, and describes the pseudonymous city of Tianmai. The author then suggests that due to key differences between professional responsibility as it is defined in the clinical and public health settings - particularly with regards to the aggregate nature of the public health "client" – a bifurcation of service and governance arose in Tianmai between a "common" being served and local populations being governed. The chapter lays out five "commons" that will be examined in the rest of the book: a civilized immigrant common, a professional common, a transnational scientific common, a global health common, and a global common. It also suggests that the Tianmai case can offer novel insights into the study of global health. 2City of Immigrants chapter abstractThis chapter takes a closer look at the immigrant city of Tianmai, and considers how the modern, cosmopolitan urban paradise that Tianmai's elites were trying to build included some and excluded others. In particular, the chapter examines the relationship – or lack thereof – between Tianmai's public health professionals and the city's enormous "floating population" of rural-to-urban migrants. The author shows how her interlocutors – former migrants themselves – refused to engage with migrant individuals, and actively maintained personal, moral, and professional boundaries between themselves and the floating population. This effectively divulged public health professionals of responsibility for the majority of the people who lived in their city and established them as "biological non-citizens" who had to be governed but could not be served. In doing this public health professionals worked to serve a civilized immigrant common of modern urban subjects that did not include the floating population. 3Relationships, Trust, and Truths chapter abstractThis chapter illustrates how the power to implement any given public health initiative in China was located within the webs of guanxi, or personal relationships, that public health professionals spun anew at the beginning of each project. Drawing on rich ethnographic description, the chapter takes the reader into the banqueting and other entertainment rituals that public health professionals engaged in almost daily in order to create and maintain these networks of reciprocal obligation and personalistic trust. The author then examines how a group of young, highly educated post-SARS reformers attempted to rid the public health system of guanxi, which they regarded as anti-scientific and akin to corruption. These reformers hoped to build a more transparent and reliable system of disease reporting and governance by establishing a professional common grounded in professionalized trust. 4Scientific Imaginaries chapter abstractThis chapter critically examines public health research and science in Tianmai. The author explores the efforts of Chinese public health professionals to advance their careers through scientific research, and discusses how in the wake of SARS, Chinese public health institutions dramatically increased their investments in scientific research – rendering publishable research a major focus of local public health work. Newly hired young people labored to produce the "quality" and "true" data that they associated with good science. They hoped that doing so would give them a chance to "develop themselves" as members of transnational scientific common, and to escape a local moral world that they felt was dominated by mimicry, deception, and instability. The chapter suggests that their approach to research provides a mirror through which public health researchers in other contexts could critically examine their own ethical practices, raising new questions about global research ethics. 5Pandemic Betrayals chapter abstractThis chapter provides an ethnographically rich eyewitness account of Tianmai's response to the 2009 H1N1 influenza pandemic, describing how public health professionals in Tianmai drew upon the lessons of SARS to mount what they thought would be an internationally lauded response to H1N1. In attempting to prove their pandemic preparedness capabilities and ensure a place among the global scientific elite, however, Tianmai's public health professionals instead found that their full admittance into a global health common and a global common remained elusive. The chapter discusses the professionals' difficulties in escaping their perceived status as a source, rather than a victim, of dangerous viruses; their use of disease control tactics that were portrayed abroad as excessive and unsophisticated; and their disappointment with the failure of their leaders and guanxi partners to act in the professional fashion that they had been trying to promote since SARS. 6Conclusion chapter abstractThe concluding chapter returns to the broader question of what professional responsibility can or should mean in public health and beyond, and asks how public health professionals in China could work to reconcile the "common" with the "population," and population needs with individual needs. The author uses the case of HIV/AIDS to examine the ways in which some public health professionals in Tianmai were experimenting with alternative interpretations of public health that broadened the boundaries of the common to allow in otherwise maligned groups, including rural migrants, gay men, and sex workers. The book ends by considering the implications of this ethnography for the study of public health – both local and global – more broadly.

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Book SynopsisTrade Review"In this defining ethnography of China's public health system and its complex relation to epidemics, Katherine Mason brilliantly describes health professionals, their struggles to be effective and ethical, the barriers they face, and how they animate the Chinese public health system as a lived reality. Infectious Change is an impressive contribution to both China studies and to medical anthropology!" -- Arthur Kleinman, Director * Harvard Asia Center *"Meticulously crafted, Infectious Change draws readers into the world of Chinese public health after SARS. Mason documents fundamentally different approaches to epidemic control among global, state, and local practitioners, including management of migratory populations, data collection, and ethics, arguing that global directives often stymie local efforts. This book elucidates why epidemic prevention everywhere must draw on local knowledge and practices." -- Margaret Lock * author of The Alzheimer Conundrum *"Infectious Change brings us for the first time before a hitherto unacknowledged consequence of the 2009 H1N1 crisis, and, at that, in one of the most epidemiologically critical regions of the globe today. It is this invaluable insight that should hold the attention not only of medical anthropologists but also of the wider global health community." -- Christos Lynteris * Medical Anthropology Quarterly *"This is an excellent, thought-provoking book, which will appeal to those with interests in contemporary China, medical anthropology, and histories of health and disease. It yields insights that will illuminate broader debates, such as those that pivot on the challenges inherent in promoting the "global" as a category in health." -- Robert Peckham * Bulletin of the History of Medicine *"Katherine Mason's book is an important contribution to the fields of Chinese studies and anthropology, joining a recent spate of excellent studies using the methods of anthropology to look at the intersections of public health, cultural practices and politics in China...Mason's book reminds us that implementing public health policy is never only about what is technically correct. It is about the cultural values and practices that govern relationships. It is also about understanding the power dynamics of the political system and generating the political will to construct an enabling environment and accountability mechanism to achieve it. In China, the tensions between centre and local are rarely resolved in favour of local and when new criteria for professional advancement are introduced, it results in the type of dysfunction so masterfully described by Mason." -- Joan Kaufman * China Quarterly *"In Infectious Change, Katherine A. Mason provides a captivating analysis of public health in China in the wake of SARS...Infectious Change is an insightful work that would be of interest to scholars of China and global health practitioners while also being accessible to a general academic reader. For China scholars, Mason makes a major contribution to the literature on public health." -- Emilio Dirlikov * Anthropological Quarterly *"Infectious Change presents a rich ethnographic account of how the Tianmai CDC works, how it would like to transform itself, and the barriers to doing so. It will make an excellent addition to courses on the anthropology of China or of global health because of the clarity of its ethnographic account and also because of the questions it opens up."––Elanah Uretsky, Asian MedicinTable of ContentsContents and Abstracts1Introduction chapter abstractThis chapter situates the reader in time and space and lays out the main arguments of the book. The author provides an overview of the recent history of public health in China, and describes the pseudonymous city of Tianmai. The author then suggests that due to key differences between professional responsibility as it is defined in the clinical and public health settings - particularly with regards to the aggregate nature of the public health "client" – a bifurcation of service and governance arose in Tianmai between a "common" being served and local populations being governed. The chapter lays out five "commons" that will be examined in the rest of the book: a civilized immigrant common, a professional common, a transnational scientific common, a global health common, and a global common. It also suggests that the Tianmai case can offer novel insights into the study of global health. 2City of Immigrants chapter abstractThis chapter takes a closer look at the immigrant city of Tianmai, and considers how the modern, cosmopolitan urban paradise that Tianmai's elites were trying to build included some and excluded others. In particular, the chapter examines the relationship – or lack thereof – between Tianmai's public health professionals and the city's enormous "floating population" of rural-to-urban migrants. The author shows how her interlocutors – former migrants themselves – refused to engage with migrant individuals, and actively maintained personal, moral, and professional boundaries between themselves and the floating population. This effectively divulged public health professionals of responsibility for the majority of the people who lived in their city and established them as "biological non-citizens" who had to be governed but could not be served. In doing this public health professionals worked to serve a civilized immigrant common of modern urban subjects that did not include the floating population. 3Relationships, Trust, and Truths chapter abstractThis chapter illustrates how the power to implement any given public health initiative in China was located within the webs of guanxi, or personal relationships, that public health professionals spun anew at the beginning of each project. Drawing on rich ethnographic description, the chapter takes the reader into the banqueting and other entertainment rituals that public health professionals engaged in almost daily in order to create and maintain these networks of reciprocal obligation and personalistic trust. The author then examines how a group of young, highly educated post-SARS reformers attempted to rid the public health system of guanxi, which they regarded as anti-scientific and akin to corruption. These reformers hoped to build a more transparent and reliable system of disease reporting and governance by establishing a professional common grounded in professionalized trust. 4Scientific Imaginaries chapter abstractThis chapter critically examines public health research and science in Tianmai. The author explores the efforts of Chinese public health professionals to advance their careers through scientific research, and discusses how in the wake of SARS, Chinese public health institutions dramatically increased their investments in scientific research – rendering publishable research a major focus of local public health work. Newly hired young people labored to produce the "quality" and "true" data that they associated with good science. They hoped that doing so would give them a chance to "develop themselves" as members of transnational scientific common, and to escape a local moral world that they felt was dominated by mimicry, deception, and instability. The chapter suggests that their approach to research provides a mirror through which public health researchers in other contexts could critically examine their own ethical practices, raising new questions about global research ethics. 5Pandemic Betrayals chapter abstractThis chapter provides an ethnographically rich eyewitness account of Tianmai's response to the 2009 H1N1 influenza pandemic, describing how public health professionals in Tianmai drew upon the lessons of SARS to mount what they thought would be an internationally lauded response to H1N1. In attempting to prove their pandemic preparedness capabilities and ensure a place among the global scientific elite, however, Tianmai's public health professionals instead found that their full admittance into a global health common and a global common remained elusive. The chapter discusses the professionals' difficulties in escaping their perceived status as a source, rather than a victim, of dangerous viruses; their use of disease control tactics that were portrayed abroad as excessive and unsophisticated; and their disappointment with the failure of their leaders and guanxi partners to act in the professional fashion that they had been trying to promote since SARS. 6Conclusion chapter abstractThe concluding chapter returns to the broader question of what professional responsibility can or should mean in public health and beyond, and asks how public health professionals in China could work to reconcile the "common" with the "population," and population needs with individual needs. The author uses the case of HIV/AIDS to examine the ways in which some public health professionals in Tianmai were experimenting with alternative interpretations of public health that broadened the boundaries of the common to allow in otherwise maligned groups, including rural migrants, gay men, and sex workers. The book ends by considering the implications of this ethnography for the study of public health – both local and global – more broadly.

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Book SynopsisGeorge Dehner examines the wide disparity in national and international responses to influenza pandemics, from the Russian flu of 1889 to the swine flu outbreak in 2009. He chronicles the technological and institutional progress made along the way and shows how these developments can shape an effective future policy.

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Book SynopsisThe first reports of the successful use of mechanical ventilation to treat respiratory disorders in the neonate were published in the 1960s.Trade Review"Four Stars" "This is a complete overview of every aspect of respiratory interventions and assessments. I am very impressed with the chapters and information available of the new state-of-the-art ventilators and the wider ranges of modalities that are extensively covered. This information may help clinicans narrow the options when faced with so many choices and options in ventilaor management. The binding is also convenient and allows the pages to lay flat. The list of abbreviations is complete. Not only is there a detailed table of contents, but index as well. "I have had 17 years of neonatal experience and I find a great need for a current, updated manual to have as a reference in a Level III NICU. I appreciate involvement that respiratory care practitioners had with the physicians in the development of this manual. These contributors are widely respected and experts in the field." Doody’s Review Service "The manual with its large font size, simple line diagrams and easy to read text makes it a very readable book. It is strongly recommended for residents, consultants and nurses providing active neonatal respiratory support." Indian Paediatrics "The extent of coverage, easy readability, and superb organization in conjunction with the plethora of practical pearls make it worthwhile having access to this book in a bed-side library. For a price tag of $89.00, it is simply a great bargain." Journal of Perinatology "This is a complete book that covers what you need when taking care of critical infants with respiratory disease. It enhances the collaboration of the health care team in the NICU and promotes the team’s efficiency in managing these ill infants. By thoroughly understanding and applying the information in this volume, the survival rate in the NICU may be increased and the complication rate will decrease. Journal of Pediatric NursingTable of ContentsForeword. Alan H. Jobe. Preface. Abbreviations Used in This Book. Section I. Lung Development and Normal Pulmonary Physiology. Chapter 1. Development of the Respiratory System. (Vinod K. Bhutani). Chapter 2. Spontaneous Breathing. (Emidio M. Sivieri, Vinod K. Bhutani). Chapter 3. Pulmonary Gas Exchange. (Vinod K. Bhutani). Chapter 4. Pulmonary Mechanics. (Emidio M. Sivieri, Vinod K. Bhutani). Section II. Assessment of Cardiopulmonary Function. Chapter 5. Clinical Examination. (N.R.C. Roberton). Chapter 6. Radiography. (Lawrence R. Kuhns). Chapter 7. Interpretation of Blood Gases. (David J. Durand). Chapter 8. Neonatal Graphic Monitoring. (Joanne J. Nicks). Chapter 9. Continuous Monitoring Techniques. (Christian F. Poets, David P. Southall). Chapter 10. Echocardiography. (Jonathan P. Wyllie). Section III. Neonatal Respiratory Failure. Chapter 11. Indications for Mechanical Ventilation. (Anne Greenough, Anthony D. Milner). Chapter 12. Mechanisms of Respiratory Failure. (Anne Greenough, Anthony D. Milner). Chapter 13. Tissue Hypoxia. (Anne Greenough, Anthony D. Milner). Chapter 14. Neonatal Resuscitation. (Janet M. Rennie). Section IV. Mechanical Ventilation. Chapter 15. Basic Principles of Mechanical Ventilation. (Waldemar A. Carlo, Namasivayam Ambalavanan, Robert L. Chatburn). Chapter 16. Classification of Mechanical Ventilation Devices. (Waldemar A. Carlo, Namasivayam Ambalavanan, Robert L. Chatburn). Chapter 17 Ventilator Parameters. (Waldemar A. Carlo, Namasivayam Ambalavanan, Robert L. Chatburn). Section V. Conventional Ventilation. Chapter 18. Continuous Positive Airway Pressure. (Colin J. Morley). Chapter 19. Intermittent Mandatory Ventilation. (Cheryll K. Hagus). Chapter 20. Assist/Control Ventilation. (Steven M. Donn, Sunil K. Sinha). Chapter 21. Synchronized Intermittent Mandatory Ventilation. (Steven M. Donn, Sunil K. Sinha). Chapter 22. Volume-Controlled Ventilation. (Steven M. Donn, Kenneth P. Bandy). Chapter 23. Pressure Support Ventilation. (Sunil K. Sinha, Steven M. Donn). Chapter 24. Pressure Control and Pressure-Regulated Volume-Controlled Ventilation. (Mary K. Dekeon). Section VI. Neonatal Ventilator. Chapter 25. VIP BIRD® Infant/Pediatric Ventilator. (Michael A. Becker, Steven M. Donn). Chapter 26. Dräger Babylog 8000 Plus® Infant Care Ventilator. (Donald M. Null, Jr.). Chapter 27. SLE 2000® (HFO) Ventilator. (J. Harry Baumer). Chapter 28. Sechrist Model IV-200 SAVI® Ventilator. (S. David Ferguson). Chapter 29. Newport Wave® Ventilator. (Robert L. Chatburn). Chapter 30. Bear Cub 750 PSV® Infant Ventilator. (Cheryll K. Hagus). Chapter 31. Siemens Servo 300® Ventilator. (Mary K. Dekeon). Chapter 32. Infant Star® Ventilator. (Graham Bernstein). Section VII. Neonatal Apnea. Chapter 33. Apnea Syndromes. (Charles A. Pohl, Alan R. Spitzer). Chapter 34. Diagnosis of Apnea. (Charles A. Pohl, Alan R. Spitzer). Chapter 35. Treatment of Apnea. (Charles A. Pohl, Alan R. Spitzer). Section VIII. High-Frequency Ventilation. Chapter 36. General Concepts of High-Frequency Ventilation. (Bert Bunnell). Chapter 37. High-Frequency Jet Ventilation and the Bunnell Life Pulse® High-Frequency Jet Ventilator. (Martin Keszler). Chapter 38. High-Frequency Oscillatory Ventilation. (Reese H. Clark, Dale R. Gerstmann). Chapter 39. SensorMedics 3100A® High-Frequency Oscillatory Ventilator. (Jeanette M. Asselin). Section IX. Management of Specific Respiratory Disorders. Chapter 40. Respiratory Distress Syndrome. (Steven M. Donn, Sunil K. Sinha). Chapter 41. Meconium Aspiration Syndrome. (Thomas E. Wiswell). Chapter 42. Neonatal Pneumonia. (Roger G. Faix). Chapter 43. Persistent Pulmonary Hypertension of the Newborn. (Robert E. Schumacher, Steven M. Donn). Chapter 44. Neonatal Pulmonary Hemorrhage. (Tonse N.K. Raju). Chapter 45. Thoracic Air Leaks. (Kim K. Tekkanat, Steven M. Donn). Chapter 46. Congenital Diaphragmatic Hernia. (David Field). Chapter 47. Pulmonary Hypoplasia. (David Field). Chapter 48. Bronchopulmonary Dysplasia. (Jonathan M. Davis). Section X. Complications of Mechanical Ventilation. Chapter 49. Airway and Respiratory Complications of Mechanical Ventilation. (Steven M. Donn, Sunil K. Sinha). Chapter 50. Patent Ductus Arteriosus. (Jonathan P. Wyllie). Chapter 51. Neurologic Complications of Mechanical Ventilation. (Jeffrey M. Perlman). Chapter 52. Retinopathy of Prematurity. (Alistair R. Fielder). Section XI. Sedation and Control of Pain. Chapter 53. Assessment of Pain and Sedation. (Susan Kidd, Neil McIntosh). Chapter 54. Pharmacologic Intervention. (Gopi Menon, Christine A. Walker, Neil McIntosh.). Chapter 55. Effects of Inadequate Analgesia or Sedation. (Jan Reiss, Neil McIntosh). Section XII. Weaning from Mechanical Ventilation. Chapter 56. Essentials of Weaning. (Steven M. Donn, Sunil K. Sinha). Chapter 57. Weaning Strategies. (Steven M. Donn, Sunil K. Sinha). Chapter 58. Adjunctive Treatments for Weaning. (Steven M. Donn, Sunil K. Sinha). Chapter 59. Impediments to Weaning. (Steven M. Donn, Sunil K. Sinha). Chapter 60. Extubation and Postextubation Care. (Steven M. Donn, Sunil K. Sinha). Section XIII. Nursing Care. Chapter 61. Nursing Documentation. (Mary E. Linton). Chapter 62. Chest Physiotherapy/Postural Drainage. (Jill M. Neubert). Chapter 63. Endotracheal Tube Suctioning. (Mary E. Linton). Section XIV Special Procedures. Chapter 64. Laryngoscopy and Endotracheal Intubation. (Sam W. J. Richmond). Chapter 65. Replacing the Endotracheal Tube. (Sunil K. Sinha, Jonathan P. Wyllie, Steven M. Donn). Chapter 66. Transillumination. (Kim K. Tekkanat, Steven M. Donn). Chapter 67. Evacuation of Air Leaks. (Kim K. Tekkanat, Steven M. Donn). Chapter 68. Vascular Access. (Steven M. Donn, Kim K. Tekkanat). Chapter 69. Bronchoscopy. (Neil N. Finer). Chapter 70. Tracheostomy. (Steven M. Donn). Section XV. Pharmacologic Agents Used in Respiratory Care. Chapter 71. Surfactants. (Dharmapuri Vidyasagar). Chapter 72. Adjunctive Pharmacologic Agents. (Sam W.J. Richmond). Section XVI. Transport of Ventilated Babies. Chapter 73. Transport Equipment. (Steven M. Donn, Molly R. Gates). Chapter 74. Stabilization of the Transported Newborn. (Steven M. Donn, Molly R. Gates). Chapter 75. Special Considerations. (Steven M. Donn, Molly R. Gates). Section XVII. Alternative Therapies for Intractable Respiratory Failure. Chapter 76. Extracorporeal Membrane Oxygenation. (Robert E. Schumacher). Chapter 77. Inhaled Nitric Oxide Therapy. (Martha Nelson). Chapter 78. Liquid Ventilation for Neonatal Respiratory Failure. (David S. Foley, Ronald B. Hirschl). Section XVIII. Outcome of Neonatal Intensive Care. Chapter 79. Discharge Planning of the NICU Graduate. (Win Tin, Unni Wariyar). Chapter 80. Follow-Up of the NICU. (Graduate.Win Tin, Unni Wariyar). Section XIX. Ethical Considerations. Chapter 81. Initiation of Life Support at the Border of Viability. (Daniel G. Batton, Jeffrey Maisels). Chapter 82. Withdrawal of Ventilatory Support. (Malcolm L. Chiswick). Section XX. Ventilatory Case Studies. Chapter 83. Ventilatory Case Studies. (Marie C. McGettigan, Jay P. Goldsmith). Appendix. Index.

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Book SynopsisMolecular Aspects of Aging: Understanding Lung Aging covers recent research in the mechanisms that contribute to cellular senescence.Table of ContentsContributors xi Preface xiii 1 The Demography of Aging 1 David E. Bloom and Sinead Shannon 1.1 Introduction 1 1.2 Demographic trends 1 1.2.1 Fertility rates 2 1.2.2 Mortality rates and life expectancy 2 1.2.3 Proportion of older people 3 1.3 Impact of aging 4 1.3.1 Noncommunicable disease trends 4 1.3.2 Risk factors 5 1.3.3 Impact of NCDs on health and disability 6 1.3.4 Increase in multimorbidities 7 1.3.5 Impact on expenditure 7 1.4 Policy responses 8 1.4.1 Preventing and managing NCDs 8 1.4.2 Promoting exercise 9 1.4.3 Monitoring health-risk behaviors (and chronic health conditions) 9 1.5 Conclusion 9 References 10 2 The Omics of Aging: Insights from Genomes upon Stress 13 Ismene Karakasilioti, Anna Ioannidou, and George A. Garinis 2.1 Introduction 13 2.2 Safeguarding the nuclear genome 14 2.3 NER progerias and their connection to lifespan regulatory mechanisms 15 2.4 Triggering a survival response in the absence of a DNA repair defect 16 2.5 The omics connection between progeria and longevity 19 2.6 Triggering of systemic versus cell-autonomous features of the survival response 20 2.7 The omics connection between NER progeria, transcription, and longevity 21 2.8 Future perspectives 22 References 22 3 Protein Quality Control Coming of Age 27 Silke Meiners 3.1 Introduction 27 3.2 The aging molecular chaperone network 29 3.3 Protein degradation pathways in aging 30 3.3.1 Lysosomal autophagy pathway 30 3.3.2 Ubiquitin–proteasome system 32 3.4 Compartment-specific protein quality control 34 3.4.1 The aging ER stress response 34 3.5 Conclusion 35 References 35 4 Telomerase Function in Aging 41 Rodrigo T. Calado 4.1 Telomeres 41 4.2 Telomerase 43 4.3 Telomeres and human disease 45 4.3.1 Telomere dysfunction in the lungs 46 4.4 Telomeres biology, aging, and longevity 47 4.5 Conclusion 48 References 48 5 The Cellular Senescence Program 53 Pooja Shivshankar and Claude Jourdan Le Saux 5.1 Cellular senescence and evidence of senescence in a cell 53 5.1.1 Characteristics of senescent cells and the inflammatory microenvironment 53 5.1.2 Detection of senescent cells in vitro and in vivo 54 5.2 Conditions associated with cellular senescence 55 5.2.1 Oxidative stress 55 5.2.2 DNA damage 55 5.2.3 Cell cycle arrest and senescence 56 5.3 Mechanisms/pathways of senescence induction 56 5.3.1 The p53/p21 pathway 56 5.3.2 The p16/pRB pathway 57 5.3.3 Convergence/coactivation of p53/p21 and p16/pRB pathways 57 5.3.4 Induction of senescence via molecular signaling 57 5.4 Cellular senescence in aging and age-related diseases of the lungs 58 5.4.1 Normal aging 59 5.4.2 Pneumonia 59 5.4.3 Chronic obstructive pulmonary disease 60 5.4.4 Idiopathic pulmonary fibrosis 60 5.5 Conclusion 61 References 61 6 Signaling Networks Controlling Cellular Senescence 67 Leena P. Desai, Yan Y. Sanders, and Victor J. Thannickal 6.1 Introduction 67 6.2 Classification of cellular senescence 69 6.2.1 Intrinsic pathway 69 6.2.2 Extrinsic pathway 69 6.2.3 Reversibility of cellular senescence 70 6.3 Cross talk of signaling pathways 70 6.3.1 Protein kinases 70 6.3.2 Metabolic pathways 71 6.3.3 Mitochondria and reactive oxygen species 71 6.3.4 Integrin and focal adhesion signaling 72 6.3.5 Transforming growth factor-β1 73 6.3.6 Epigenetic mechanisms 73 6.4 Conclusion 76 References 77 7 Immune Senescence 85 Kevin P. High 7.1 Introduction 85 7.2 Barrier defenses and innate immunity in older adults 86 7.2.1 Barrier defenses 86 7.2.2 Innate immunity 86 7.3 Adaptive immune responses 88 7.3.1 B cell number and function 88 7.3.2 T cell number, subtypes, and function 89 7.3.3 T cell activation, differentiation, exhaustion, and senescence 90 7.4 Consequences of immune senescence 91 7.4.1 Impaired vaccine responses, increased risk of infection, and age-related illness 91 7.4.2 Immune senescence: A cause of aging itself 93 7.5 Conclusion 94 References 95 8 Developmental and Physiological Aging of the Lung 99 Kent E. Pinkerton, Lei Wang, Suzette M. Smiley-Jewell, Jingyi Xu, and Francis H.Y. Green 8.1 Introduction 99 8.2 The aging lung 99 8.2.1 Alterations in lung function and anatomy 99 8.2.2 Oxidative stress and lung antioxidant defenses 101 8.2.3 Immune system changes with aging 101 8.2.4 Body mass 102 8.2.5 Airway receptor and endocrine changes with aging 103 8.3 An animal model of the aging lung: The rat 104 8.3.1 The tracheobronchial tree and epithelium of the aging rat 104 8.3.2 Parenchymal lung structure in the aging rat 105 8.3.3 Alveolar tissue compartments 106 8.4 Conclusion 110 Acknowledgments 110 References 111 9 Mouse Models to Explore the Aging Lung 117 Mingyi Wang and Deepak A. Deshpande 9.1 Pulmonary changes during aging 117 9.1.1 Advantages of mouse models for studying physiological lung changes 118 9.2 Key findings from mouse models of aging 119 9.2.1 Longevity and lung function in mice 120 9.2.2 Different strains of mice have different alterations in lung mechanics 120 9.2.3 Transgenic mouse model to study aging in the lungs 121 9.3 Age is a risk factor for obstructive pulmonary diseases 123 9.4 Challenges ahead 124 9.5 Conclusion 125 Acknowledgments 126 References 126 10 Evidence for Premature Lung Aging of the Injured Neonatal Lung as Exemplified by Bronchopulmonary Dysplasia 131 Anne Hilgendorff 10.1 Introducing bronchopulmonary dysplasia 131 10.2 Altered pulmonary function in infants with BPD 132 10.3 Response to injury 133 10.3.1 Oxidative stress response 134 10.3.2 Extracellular matrix remodeling 136 10.3.3 Inflammation 136 10.3.4 Morphogenetic response 137 10.4 Prenatal and genetic predisposition 137 10.5 Conclusion 138 References 138 11 Remodeling of the Extracellular Matrix in the Aging Lung 145 Jesse Roman 11.1 Introduction 145 11.2 The aging lung 145 11.3 Activation of tissue remodeling in the senescent lung 146 11.4 The aging lung fibroblast 148 11.5 Potential role of oxidant stress in triggering remodeling in the aging lung 149 11.6 Implications for remodeling of the lung extracellular matrix in the aged lung 150 11.7 Conclusions 152 Acknowledgments 154 References 154 12 Aging Mesenchymal Stem Cells in Lung Disease 159 Maria G. Kapetanaki, Ana L. Mora, and Mauricio Rojas 12.1 Aging and lung diseases 159 12.2 Mesenchymal stem cells (MSCs) 160 12.2.1 Description of MSCs 160 12.2.2 Characterization of MSCs 160 12.2.3 Functional properties of MSCs 161 12.3 Impact of aging on mesenchymal stem cells 162 12.3.1 In vitro aging of MSCs 162 12.3.2 Age-related changes in B-MSCs 163 12.3.3 Aging of B-MSCs versus aging of the organism 163 12.4 B-MSCs in disease 164 12.5 B-MSCs in therapy 166 12.5.1 Ex vivo expansion 166 12.5.2 Conditions affecting the expansion 167 12.5.3 Autologous versus allogeneic B-MSCs 167 12.5.4 Combination of cell preparations 167 12.5.5 Delivery and targeting 167 12.6 Conclusion 167 Acknowledgments 168 References 168 13 COPD as a Disease of Premature Aging 173 Laurent Boyer, Jorge Boczkowski, and Serge Adnot 13.1 Introduction 173 13.2 Senescent cells contribute to the pathogenesis of COPD 174 13.2.1 Accumulation of senescent cells in COPD lungs 174 13.2.2 Inflammation and lung-cell senescence in COPD 175 13.2.3 Emphysema and lung-cell senescence in COPD 176 13.2.4 Pulmonary hypertension and cell senescence in COPD 177 13.3 Lung dysfunction and the general process of premature aging in COPD 179 13.3.1 Clinical manifestations of premature aging in COPD patients 179 13.3.2 Role for lung alterations in systemic premature aging during COPD 180 13.4 Conclusion 181 References 181 14 Lung Infections and Aging 185 Jacqueline M. Kruser and Keith C. Meyer 14.1 Introduction 185 14.2 Aging and immunosenescence 185 14.2.1 Innate immunity 187 14.2.2 Adaptive immunity 188 14.2.3 Autoimmunity 189 14.2.4 Lung-specific changes in immunity with aging 190 14.3 Inflamm-aging and susceptibility to infection 190 14.4 Respiratory infection and regulation of host responses 192 14.5 Preventing respiratory infection 194 14.6 Summary and conclusions 195 References 195 Index 201

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Book SynopsisA succinct yet comprehensive overview of respiratory medicine, written for students and professionals Essential Respiratory Medicine is an indispensable text offering an understanding of respiratory conditions and their clinical management within evidence-based guidelines. Containing information on taking a medical history, performing examinations and investigations, diagnosis and the management of respiratory conditions, this comprehensive text was put together by a noted expert in the field. Written in an accessible manner, Essential Respiratory Medicine contains the foundational science associated with respiratory medicine, a wide-variety of practical procedures, helpful diagrams, and self-assessments designed to enhance understanding of the material presented. The text covers a variety of conditions as well as providing suggestions for engaging with patients at different stages of care. This important resource: Demonstrates an effective approach to patients presenting with common respiratory symptoms Includes a description of all key practical procedures with diagramsDiscusses acute management of important respiratory emergenciesCovers both acute and chronic diseaseContains a companion website containing a range of learning materials, including downloadable management summaries and algorithms, an image bank, videos of patient examination, example respiratory sounds and multiple-choice questions Essential Respiratory Medicine is an essential resource for anyone on a clinical placement, rotation, or training programme in respiratory medicine.Table of ContentsAbout the author ix Acknowledgements xi About the companion website xiii 1 Introduction to respiratory medicine 1 2 Embryology, anatomy, and physiology of the lung 5 3 Pharmacology of the lung 29 4 Common respiratory investigations 51 5 Common presentations of respiratory disease 83 6 Obstructive airways disease 105 7 Diffuse parenchymal lung disease 137 8 Respiratory infections 173 9 Lung cancer 205 10 Pleural disease 235 11 Pulmonary embolus, pulmonary hypertension, and vasculitides 267 12 Suppurative lung disease 293 13 Respiratory failure 317 14 Sleep‐related disorders 333 15 Occupational, environmental, and recreational lung disease 353 16 Disorders of the mediastinum 369 17 Acute lung injury and acute respiratory distress syndrome 383 Index 395

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Book SynopsisComprehensive Tracheostomy Care is a resource developed by the UK National Tracheostomy Safety Project (NTSP) to help promote and facilitate the safe management of tracheostomies and laryngectomies.Table of ContentsNTSP Editorial board, vii Preface, ix Acknowledgements, xi Competing interests, xiii Disclaimer, xv Contact details and further information, xvii Executive summary and Key recomendations, xix 1 How the NTSP resources were developed, 1 2 What is a tracheostomy? What is a laryngectomy?, 3 3 Why and how a tracheostomy is performed, 7 4 Different types of tracheostomy tubes, 20 5 Management of the day-to-day needs of the patient with a tracheostomy and laryngectomy, 28 6 Complications, 67 7 Redflags, 72 8 Emergency management of the patient with a tracheostomy or laryngectomy, 74 9 Paediatric tracheostomy care (with Great Ormond Street Hospital, London), 85 10 Infrastructure considerations, 111 11 Competencies for staff caring for patients with tracheostomies or laryngectomies, 117 12 Courses, 122 13 Human factors, 124 Bibliography, 131

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Book SynopsisFrom the publishers of the market leading at a Glance series, and in collaboration with the Association of Respiratory Nurses (ARNS), comes this easy-to-read, highly visual guide bringing together key principles of Respiratory Nursing.Trade ReviewThis text presents information on respiratory conditions in a succinct manner, beginning with an overview of the historical context of respiratory nursing and moving on to discuss anatomy and physiology, epidemiology, exercise, nutrition and pulmonary rehabilitation.There are two particularly good chapters that summarise history-taking and physical assessment, which are skills that nurses are increasinglyexpected to have......The book has a strong nursing focus and provides an excellent overview of the topic. It would be suitable for newly-qualified staff and those with more experience, such as clinical nurse specialists and ward managers. (Nursing Standard- December 2016)Table of ContentsContributors vii Preface viii About ARNS ix Part 1 The context of respiratory nursing 1 1 The origins of respiratory nursing 2 2 Working in secondary care 4 3 Working in primary care 5 4 Ambulatory, intermediate and tertiary care 6 5 The future of respiratory nursing 7 6 Respiratory public health 8 Part 2 Respiratory health 11 7 The respiratory system 12 8 Preventing respiratory disease 14 9 Epidemiology and contributing factors 16 10 Smoking and smoking cessation 18 11 Exercise and pulmonary rehabilitation 20 12 Nutrition and hydration 22 13 The upper airways 24 14 Respiratory disease and sexuality 26 Part 3 Assessment and diagnosis of respiratory disease 29 15 Respiratory history taking 30 16 Respiratory clinical examination 32 17 Measuring dyspnoea 34 18 Sputum assessment 36 19 Pulse oximetry 38 20 Blood gas sampling and analysis 40 21 Spirometry 42 22 Measuring quality in healthcare 44 23 Assessing anxiety and depression 46 Part 4 Respiratory diseases 49 24 Asthma 50 25 Chronic obstructive pulmonary disease 52 26 Pleural disease 54 27 Lung cancer 56 28 Obstructive sleep apnoea syndrome 58 29 Acute respiratory infections 60 30 Cystic fibrosis 62 31 Bronchiectasis 64 32 Occupational and environmental lung disease 66 33 Interstitial lung disease 68 34 Sarcoidosis 70 35 Pulmonary tuberculosis 72 36 Venous thromboembolism and pulmonary embolism 74 37 HIV and respiratory disease 76 Part 5 Models of care 79 38 Care pathways and care bundles 80 39 Self-management in chronic respiratory disease 82 40 Telemedicine and telehealth 84 41 Patient education 86 42 Voluntary organisations and patient support groups 88 Part 6 Respiratory medication 91 43 Pharmacology and prescribing 92 44 Inhaler technique 94 45 Nebuliser therapy 96 46 Emergency oxygen therapy 98 47 Domiciliary oxygen therapy 100 48 Other routes of administration 102 49 Adherence and concordance 103 Part 7 Acute care of the respiratory patient 105 50 Respiratory failure 106 51 Pre-hospital care 108 52 Non-invasive and invasive ventilation 110 53 Pleural procedures and management 112 54 Tracheostomy care and management 114 Part 8 Supportive and palliative care 117 55 Communication 118 56 Psychosocial impact of respiratory disease 120 57 Management of dyspnoea 122 58 Anxiety and depression in respiratory disease 124 59 Other symptom management 126 60 NIV as a domiciliary therapy 128 61 End-of-life care 130 62 Families and carers 132 References 134 Index 139

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Book SynopsisLung Cancer: A Multidisciplinary Approach provides clinicians with a comprehensive text that can be used when caring for patients with lung cancer throughout the entire patient journey. This edited collection explores the aetiology of lung cancer; mesothelioma; the range of available treatments, including chemotherapy and radiotherapy; surgical care; supportive and end-of-life care; quality-of-life issues; and the role of the nurse within the multidisciplinary team. A comprehensive, evidence-based guide to lung cancer Illustrative case studies used throughout Contributions from respected healthcare professionals in the field Interprofessional in focus Lung Cancer: A Multidisciplinary Approach is an essential resource for all nurses and healthcare professionals working with cancer patients.Trade Review“This is a superb book that includes a huge amount of relevant and up-to-date information without appearing to be cumbersome. It will be invaluable to all healthcare professionals caring for patients with lung cancer.” (Nursing Standard, 1 February 2013) “This well-written book can be quite useful as a resource for RNs and other healthcare professionals caring for lung cancer patients.” (Doody's, 3 August 2012) “I recommend this volume as a resource for students, staff new to the field and qualified professionals. It provides a comprehensive overview of the main issues faced by patients diagnosed with this aggressive disease.” (Cancer Nursing Practice, 1 June 2012)Table of ContentsContributors ix Acknowledgements xi 1 Introduction to Lung Cancer and Mesothelioma 1 Alison Leary Introduction 1 Epidemiology and causes of lung cancer 2 Overview of the types of lung cancer 6 Delivering cancer services and the multidisciplinary team 8 Meeting information needs 11 Summary 13 References 13 2 The Presentation and Diagnosis of Lung Cancer and Mesothelioma 15 Neal Navani and Stephen G. Spiro Introduction 15 Clinical features of lung cancer 17 Paraneoplastic syndromes 22 Risk factors for lung cancer 26 Performance status 27 Investigation of lung cancer 28 Staging of lung cancer 38 An algorithm for the diagnosis and staging of non-small-cell lung cancer 41 Mesothelioma 42 Summary 46 References 46 Further reading 47 3 Chemotherapy and Biological Agents 49 Fharat A. Raja and Siow Ming Lee Introduction 49 Chemotherapy 50 Chemotherapy for advanced NSCLC 53 Addition of targeted therapies to chemotherapy in NSCLC 55 Chemotherapy for small-cell lung cancer 57 Mesothelioma 59 Summary 61 References 61 4 Lung Radiotherapy 65 Nita Patel and Dawn Carnell Introduction 65 Principles of radiotherapy 65 The use of radiotherapy in non-small-cell lung cancer 73 The use of radiotherapy in small-cell lung cancer 76 Palliative radiotherapy 78 Management of patients during radiotherapy 80 New techniques under evaluation 83 Summary 84 References 84 5 Surgery for Lung Cancer 87 Neil Cartwright and Aman S. Coonar Introduction 87 The role of the surgeon 89 Reaching decisions about surgery 90 Surgery for cancers of the lung 100 The role of adjuvant treatment in NSCLC 108 Palliative surgical procedures 110 Carcinoid tumours and neuroendocrine cancer 111 Surgery for small-cell lung cancer 112 Bronchoalveolar cell cancer 112 Postoperative complications, rehabilitation follow-up 112 The multidisciplinary team in postsurgical care 115 Summary 116 References 116 6 The Nursing Care of Patients with Lung Cancer 121 Sally Moore Introduction 121 What are the important issues in relation to lung cancer nursing? 122 Context of lung cancer services 123 The challenges of lung cancer 124 The role of the specialist nurse 138 Summary 139 References 139 7 Supportive Care in Lung Cancer 145 Kay Eaton Introduction 145 Supportive care 146 Communicating the 'diagnosis' 147 Attitudes towards cancer 148 Uncertainty 149 Psychological distress 150 A family-centred approach to care 152 Improving the patient experience: care across the pathway 153 Summary 156 References 156 8 End of Life Care 159 Michael Coughlan Introduction 159 Palliative and end of life care 159 Dying in the twenty-first century 160 Diagnosing dying 162 Managing complex ethical dilemmas 163 Planning care for the patient dying from lung cancer 164 Summary 181 References 182 9 Quality of Life in Lung Cancer 189 Alison Leary Introduction 189 Cancer: the journey, the individual and society 190 Doing the work of cancer and quality of life 192 Towards an understanding of the meaning of quality of life in lung cancer 192 Quality of life in advanced lung cancer: instruments used to measure health-related quality of life 197 Summary 199 References 199 Index 203

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Book SynopsisAnalyzing asthma care in the twenty-first centuryAsthma is not a new problem, but today the disease is being reshaped by changing ecologies, healthcare systems, medical sciences, and built environments. A global epidemic, asthma (and our efforts to control it) demands an analysis attentive to its complexity, its contextual nature, and the care practices that emerge from both. At once clearly written and theoretically insightful, Breathtaking provides a sweeping ethnographic account of asthma’s many dimensions through the lived experiences of people who suffer from disordered breathing, as well as by considering their support networks, from secondary school teachers and coaches, to breathing educators and new smartphone applications designed for asthma control. Against the backdrop of unbreathable environments, Alison Kenner describes five modes of care that illustrate how asthma is addressed across different sociocultural scales. These modes of care often work in combination, building from or preceding one another. Tensions also exist between them, a point reflected by Kenner’s description of the structural conditions and material rhythms that shape everyday breathing, chronic disease, and our surrounding environments. She argues that new modes of distributed, collective care practices are needed to address asthma as a critical public health issue in the time of climate change.Trade Review"This elegant first monograph from the Asthma Files Project is written simply for all audiences and provides five practical recommendations. Breathtaking is social science at its best: experiential, explanatory, critical, and providing ways forward. Alison Kenner herself is an active participant as community social-scientist and as partner to someone who suffers disordered breathing. She guides us vividly across scales and registers."—Michael M.J. Fischer, author of Anthropology in the Meantime"Breathtaking is a sweeping ethnographic account of asthma and its treatments that expertly traverses questions of lived experience, medical technology, and critical ecology as they bear on the epidemic of disordered breathing. Beautifully written and poignant, this book makes a robust contribution to our understanding of the health effects of environmental degradation and climate change, deepens the critiques of biomedicalization, and heralds the promise of complementary and alternative medicine."—Anthony Ryan Hatch, author of Blood Sugar"Breathtaking is an engrossing read."—CHOICE"Breathtaking presents a compelling and very readable ethnographic overview of the ways that asthma is grappled with across a variety of 21st century American contexts. This book offers an insightful and multi-faceted account of a condition that affects so many around the world."—Somatosphere"Overall, Breathtaking takes asthma from the biomedical world, and using a multi-sited ethnography, traces connections between the experience of asthma, the environment and our bodies, allowing us to imagine new carescapes that could make the world more breathable."—LSE Review of Books"In the absence of swift and uncompromising action on the part of US legislators to combat climate change, Kenner advocates democratizing access to affordable health care; integrating breathing training into the doctor’s toolkit; and enacting policy, at all levels of government, to improve the indoor environments in which we spend the majority of our time."—H-EnvironmentTable of ContentsIntroduction1. Attuning to Asthma in Time and Place2. Three Modes of Control as Asthma Care3. Counting on Breath: Making Time with Respiratory Retraining4. The Datafication of Care5. Public Health Carescapes for Climate ChangeConclusionAcknowledgmentsNotesBibliographyIndex

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Book SynopsisThis convenient reference provides clinicians with point-of-care guidance on the assessment and treatment of chronic and acute asthma in infants, toddlers, school-aged children, and young adults. It covers signs and symptoms, triggers, diagnostic considerations, office pulmonary testing, clinical index tools, stepped approaches to treatment by age, maintenance and control, exacerbation assessment, and more.Topics include Approach to Evaluation Diagnosis Office Pulmonary Function Testing Exacerbation Assessment Respiratory Scoring Tools Classifying Severity by Age Intervention Overview NIH/NHLBI Stepwise Approaches to Management GINA Stepped Approaches to Treatment Maintenance and Control SABAs Inhaled Corticosteroids LABAs and LTRAs Inhaled Anticholinergic Agents Systemic Corticosteroids Anti-immunoglobulin E Therapy Other Biologics Trigger Management Exercise-Induced Bronchoconstriction Asthma Control Test Tobacco Use/Vaping and Asthma Get Valid Spirometry Results Every Time Table of Contents Tab 1. Approach to Evaluation Tab 2. Diagnosis Tab 3. Office Pulmonary Function Testing Tab 4. Exacerbation Assessment Tab 5. Respiratory Scoring Tools Tab 6. Classifying Severity by Age Tab 7. Intervention Overview Tab 8. NIH/NHLBI Stepwise Approaches to Management Tab 9. GINA Stepped Approaches to Treatment Tab 10. Maintenance and Control Tab 11. SABAs Tab 12. Inhaled Corticosteroids Tab 13. LABAs and LTRAs Tab 14. Inhaled Anticholinergic Agents Tab 15. Systemic Corticosteroids Tab 16. Anti-immunoglobulin E Therapy Tab 17. Other Biologics Tab 18. Trigger Management Tab 19. Exercise-Induced Bronchoconstriction Tab 20. Asthma Control Test Tab 21. Tobacco Use/Vaping and Asthma Tab 22. Get Valid Spirometry Results Every Time

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Book SynopsisLung cancer is the leading cause of cancer-related death among men and women in the U.S. and worldwide. For many decades, lung cancer was the sole cancer among the deadly four without an evidence-based screening method for decreasing mortality. This changed in November 2011, when findings from the National Lung Cancer Screening Trial showed low-dose lung CT screening was more efficacious in reducing deaths in high-risk individuals than conventional radiography. As such, an ever-increasing number of health organizations now recommend this screening protocol. Lung Cancer Screening by Mark Parker and esteemed VCU Health colleagues, fulfills the dire need for a comprehensive guide explaining the crucial aspects of lung cancer screenings. The first two chapters lay a foundation with discussion of lung cancer epidemiology and risk factors beyond cigarette smoking. Subsequent chapters cover the fundamentals, with clinical pearls on setting up a successful lung cancer screening program, patient eligibility criteria, imaging variances of tumors in the lungs, screening pros and cons, and interpreting/reporting screening results. The evolution and future of lung cancer screenings Detection and management of unexpected incidental pulmonary and non-pulmonary findings Discussion of test cases utilizing the Lung-RADSTM risk-stratifying system for low-dose chest CT screenings Benefits and potential harms associated with mass lung cancer screening programs including false positive, false negative, and over-diagnosis rates This state-of-the-art guide is essential reading for radiologists, oncologists, pulmonologists, and internists. It is a must-have bookshelf reference for hospital radiology and oncology departments, in particular for those setting up new lung cancer screening programs.Table of Contents1 Lung Cancer Epidemiology 2 Risk Factors for Lung Cancer 3 Evolution of Lung Cancer Screening 4 Lung Cancer Screening Pros and Cons 5 Variable Imaging Presentations of Lung Cancer 6 Lung Cancer–Screening Results Reporting 7 Detection and Management of Unexpected Incidental Pulmonary and Nonpulmonary Findings 8 Elements of a Successful Lung Cancer–Screening Program 9 Future of Lung Cancer Screening 10 Test Cases: Applying Lung CT Screening Reporting and Data System (Lung-RADS)

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Book SynopsisThis edition has been extensively rewritten in order to reflect the changes in clinical practice and learning methods which have taken place since the 5th edition was published. The seventeen chapters are divided into three sections: normal voice, descriptions of the various types of voice disorders, and the methods of treating abnormal voice. A profile summary of each voice disorder is provided for easy reference and comparison, and tables are used throughout the text. New laryngeal images and electroglottographic interpretations have also been included. The current emphasis on evidence-based practice is addressed in the review and descriptions of intervention strategies used in voice therapy.Table of ContentsPart I - Communicative functions of the voice: an introduction. The larynx and upper respiratory tract. The lower respiratory tract. Normal voice and phonation. Voice mutation: infancy to senescence. Part II - Voice disorders. Presentation and classification. Hyperfunctional dysphonia. Psychogenic voice disorders. Vocal tract structural abnormalities: congenital and acquired. Neurogenic voice disorders. Laryngeal disease, inflammatory conditions and diseases affecting the vocal tract. Part III - Voice therapy: the process. Analysis and evaluation: perceptual and instrumental. Management and treatment: principles and techniques. Specific techniques. Specific intervention: children, the elderly, singers. Laryngeal carcinoma: presentation and management.

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Book SynopsisThis addition to the field of pulmonary rehabilitation will be used as a practical resource which demonstrates academic insight into new and emerging aspects of Chronic Obstructive Pulmonary Disease (COPD) rehabilitation. This book provides a European perspective with international experts contributing to the various chapters. There have been significant advances in pulmonary rehabilitation in the last decade and this is reflected in the use of up to date research and clinical opinion. Comprehensive chapters address pulmonary rehabilitation from the perspective of the patient, nursing, physio, occupational and medical therapists. Recent evaluations concern nutritional implications in COPD, selection criteria and specificity of exercise. The book examines psycho-social influences on COPD and provides practical "best evidence" treatment advice. An exciting and promising "look to the future" by Professor Calverley concludes the book. Pulmonary Rehabilitation: An Interdisciplinary Approach is an integrated evaluation of the effect of pulmonary rehabilitation on patient care, with critical assessment of outcome tools and the important contribution of an interdisciplinary approach.Table of ContentsDisability and Handicap in Copd. Selection of Patients - who benefits? Health-related Quality of Life and Pulmonary Rehabilitation. Exercise prescription and Training. Assessment of Exercise Performance and Muscle function in Pulmonary Rehabilitation. A Biopsychosocial Approach, Respiritory care at Home. Occupational Therapy in Pulmonary Rehabilitation. Physiotherapy and The Management of Dyspnoea. Cost Effectiveness of Pulmonary Rehabilitation. Future Prospects for Rehabiltation.

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Book SynopsisRemarkable advances have occurred since the Series 3 Fascicle published in 1995 with paradigm shifts in every dimension of our understanding of lung tumors including clinical, radiologic, histopathologic, cytopathologic, immunohistochemical, molecular and therapeutic aspects. The molecular revolution leading to effective targeted therapies and breakthroughs in immunotherapy for lung cancer have led to novel approaches incorporating the concept of personalized medicine for patients who historically had little hope. These advances have strengthened the place of pathologists to play a central role in the multidisciplinary team that is now needed to properly diagnose and manage lung cancer patients.

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Book SynopsisThis book serves as the primary reference for precision medicine in the fields of pulmonary, critical care and sleep medicine by documenting principles written by experts in several aspects of precision medicine. It combines fundamental concepts of the field with state-of-the-art studies and how they translate into individual preventive, diagnostic and therapeutic plans. Precision medicine is focused on the integration of individual variability with disease prevention and treatment principles derived from population studies. This concept has risen to prominence in recent years in parallel with advances in genetics, molecular diagnostics and novel target-specific therapies. This fundamental shift in the approach to treatment has broad implications in how we prevent, diagnose and treat disease. Describing key concepts of precision medicine and relating these to pulmonary, critical care and sleep disorders is essential to educate relevant stakeholders and increase the impact of pulmonary precision medicine. The book is organized into seven sections: introduction; genetics; biomarkers; precise phenotyping; mobile health, wearables and telemedicine; precision therapeutics; and enabling widespread adoption of precision medicine. The chapters are organized with an introduction to the specific theme, followed by its basic concepts. They then delve into how these basic concepts relate to the larger theme of precision medicine, new precision medicine approaches to dealing with these problems, and key takeaway points. Liberally illustrated with images, figures, and tables, the text is thorough and intuitive for clinicians and researchers to learn the processes and applications of precision medicine. This is an ideal guide for clinicians to learn new precision medicine concepts in the fields of genetics, genomics, mobile health, and how they apply to their practice and their patients, as well as researchers seeking a basic understanding of precision medicine to assist in designing future research studies. Table of ContentsIntroduction.- Differential Diagnosis of Diffuse Pulmonary Disorders Using Genetics.- Genetics and Pharmacogenetics of Asthma.- Genetics and Pharmacogenetics of COPD.- The Evolution of Precision Medicine in Cystic Fibrosis.- Genetics of Idiopathic Pulmonary Fibrosis.- Genetics of Lung Cancer.- Chest Imaging for Precision Medicine.- Biobanking for Pulmonary, Critical Care, and Sleep Medicine.- Biomarkers in Obstructive Airway Diseases.- Biomarkers in Interstitial Lung Diseases.- Molecular Diagnostics in Pulmonary Infections.- Biomarkers in Critical Care Illness: ARDS and Sepsis.- Lessons for Precision Medicine from Lung Cancer.- COPD Phenotyping.- Precision Medicine in Pulmonary Hypertension.- Identifying Subtypes of Obstructive Sleep Apnea.- Precision Medicine in Critical Illness: Sepsis and Acute Respiratory Distress Syndrome.- Mobile Applications and Wearables for Chronic Respiratory Diseases Monitoring.- Personal Environmental Monitoring.- Tele-ICU in Precision Medicine: It’s Not What You Do It’s How You Do It.- Lung Transplantation and Precision Medicine.- Precision in Mechanical Ventilation.- Precision Medicine for Cigarette Smoking Addiction.- Implementing COPD Precision Medicine in Clinical Practice .- Precision Medicine For All: Minority Health .- Education for the Practice of Precision Medicine in PCCSM: Creating Tomorrow’s Workforce.- Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care and Sleep Medicine.

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Book SynopsisThis book comprehensively presents all the necessary information health professionals need to become Certified Asthma Educators. Competent asthma educators must possess a number of skills: they must have appropriate and sound medical and pharmaceutical knowledge; be proficient and effective educators who can influence their patients’ behaviors for the better; and, finally, they need the administrative and organizational skills needed to set up and run efficient clinics at their places of work. The book is divided into three sections to meet those needs: Asthma: The Fundamentals; The Role of Education; and, The Effective Asthma Educator. The first section covers clinical knowledge of asthma, with chapters including lung structure and function, clinical presentation of asthma, and environmental issues in asthma management. The second section delves into the role of educating patients and teaches readers how to best do that with an integrated approach between physician, educator, and patient. The third section looks further into educating techniques with a view of the learning process, considerations for instruction locations, and the role the educator plays overall. The final chapter in the book presents example cases for readers to assess the knowledge they have learned throughout. This second edition serves as both textbook and study guide for certification as well as a long-term reference publication. It has been fully updated from the previous edition with the latest treatment guidelines, medications, and disease monitoring methods. This is an ideal guide for asthma educators, those seeking NAECB certification, and any health professional involved with individuals who have asthma.Table of ContentsSection I: Asthma: The Fundamentals.- Asthma: An Overview.- Lung Structure and Function.- Measurements of Lung Function.- Measurements of Lung Function.- Clinical Presentation of Asthma.- Environmental Issues in Asthma Management.- Asthma Management and Use of Medication.- Special Situations in Asthma.- Section II: The Role of Education.- An Integrated Approach to Asthma Management.- Adherence.- Complementary and Alternate Medicine and Asthma.- Frequently Asked Questions.- Section III: The Effective Asthma Educator.- Learning: Theories and Principles.- Teaching the Patient with Asthma.- Clinical Management and Evaluation.- Practice Case Studies.

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Book SynopsisThis book comprehensively covers the microbiome in respiratory disease, from the initial research study to the disease-specific implications and related applications. Research on the respiratory microbiome is increasing in volume and scope. This reflects rapidly growing interest in the study of respiratory disease to understand how microbiota shape mechanisms of disease pathogenesis. The respiratory tract spans the nasal passages, sinus cavities, oropharynx, and the tracheobronchial tree of the lungs. In these compartments of the upper and lower respiratory tract, the microbiota have now been studied in the context of several chronic respiratory conditions. These include chronic sinusitis, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis and pulmonary fibrosis, to name a few. The potential impact of ecological interactions (i.e., between microbes and between microbiota and host) within and across respiratory compartments is increasingly recognized.The book is organized into two main sections. Part I, Principles and Tools, covers conceptual modeling of the respiratory microbiome, experimental methodology with a focus on a priori considerations in study design and sampling, laboratory and computational methods for analysis of respiratory microbiome data, and minimizing interpretive pitfalls. Part II, Applications, discusses the evidence from specific studies that have shed novel insights into the influence of respiratory microbiota on mechanisms or outcomes in specific diseases. Based on current best evidence, disease-specific chapters include chronic rhinosinusitis, asthma (pediatric and adult studies), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), bronchiectasis not due to CF, idiopathic pulmonary fibrosis, and lung transplant.This is an ideal reference for forward-thinking practitioners with interest in novel developments in precision medicine applications in lung disease, as well as translational scientists in the field of microbiology, immunology and lung biology. Table of ContentsSECTION I: Principles and Tools of Respiratory Microbiome Investigation.- Conceptual Framework and Hypothesis Testing.- Study Design and Sampling Considerations.- Laboratory Platforms to Study the Microbiome.- Analysis and Reporting of Microbiome Data.- SECTION II: Applications in the Study of Specific Diseases.- Chronic Rhinosinusitis /Allergic Rhinitis.- Bronchiolitis, Viral Infection and Pediatric Asthma Risk.- Asthma Pheotype.- Cystic Fibrosis.- Bronchiectasis (non-CF).- COPD.- Idiopathic Pulmonary Fibrosis.- Lung Transplantation and Immune Suppression.- The Future: Knowledge gaps and priorities.

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Book SynopsisThis book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation Table of Contents1 Air Matters: The Effect of Ozone and Traffic Related Air Pollution on the Airways 2 Environmental Factors on Lung Healthin Cystic Fibrosis and non-Cystic Fibrosis Bronchiectasis 3 Molds and Respiratory Disease 4 Occupational exposome and lung health 5 Environmental and Pollution Related Risks for Hypersensitivity Pneumonitis 6 Lung cancer in never smokers 7 Acute and chronic lung disease from recreational inhalants 8 Pulmonary Hypertension and Air Pollution 9 Climate Change and the Lung Exposome

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Book SynopsisThis book provides an overview of sleep and sleep disorders for practicing clinicians. Sleep disorders represent a major portion of the chief complaints seen by pulmonologists and other clinicians. Patients with sleep-related conditions often present with non-specific complaints that require a broad and detailed knowledge of the wide range of sleep disorders and their consequences. This concise, evidence-based review of sleep medicine offers a guide to pulmonologists, primary care physicians, and all clinicians involved in caring for patients with sleep disorders. Providing a focused, scientific basis for the effects of sleep on human physiology, especially cardiac and respiratory physiology, chapters also outline a differential diagnosis for common sleep complaints and an evidence-based approach to diagnosis and management. This includes a review of the current standards of practice and of emerging technology and unresolved issues awaiting further research. In all, this book provides a clear diagnostic and management program for all the different sleep disorders and includes key points and summaries. This new edition expands the scope of the previous to include additional sleep disorders and the most affected populations. Six new chapters are added on health disparities in sleep medicine, models of care for patients with sleep disorders/care coordination, sleep disordered breathing in pediatric populations, sleep in hospitalized patients, sleep in pregnancy, and sleep in older patients. Essentials of Sleep Medicine is an invaluable resource for physicians, clinical psychologists, respiratory care practitioners, polysomnographic technologists, graduate students, clinical researchers, and other health professionals seeking an in-depth review of sleep medicine. Table of Contents

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Book SynopsisThis book provides healthcare professionals in Critical Care setting an easy consultation guide to fight against COVID-19. The book is divided into sections: Fundamentals of COVID-19, Pneumological critical care, Neurological manifestations, Cardiovascular manifestations, Renal manifestations, Haemostasis and coagulation, Other multi-organs involvement, Principles of therapy. Each section includes: · brief pathophysiology of COVID-19 (ventilation, neurological, cardiovascular, etc.); · principles of management (enriched with flowcharts and figures); · principles of therapy; · tips and key messages. Readers can find the most updated advices on how to face the ongoing pandemic: from principles of conventional oxygen therapy, assisted and invasive mechanical ventilation in critically ill COVID-19 patients to the complications sometimes underestimated. Tables and flowcharts provided are based on current knowledge in COVID-19 to help the clinician managing COVID-19 patients by a multiple-organs prospective. Written by international key opinion leaders of each field, the book represents a point of reference for all professionals involved in the management of COVID-19 pandemic.Table of Contents

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Book SynopsisThe only curative treatment currently available for chronic thromboembolic pulmonary hypertension (CTEPH) is surgical pulmonary endoarterectomy (PEA). However, several patients may have high risk factors for surgery, or a peripheral disease not amenable to surgical treatment; or else a residual pulmonary hypertension after PEA. Balloon pulmonary angioplasty (BPA) was recently developed to offer an alternative treatment for these patients. Extensive data has since confirmed the efficacy and relative safety of this procedure. However, there are several technical issues that have yet to be resolved. In addition, many cardiologists and pneumologists still know very little about the procedure itself and its potential.Exploring the clinical indications and technical aspects of BPA, this book offers a valuable reference guide for all those who would like to introduce or improve a BPA program, and for all those whose work involves treating this complex patient population.Table of Contents 1 Epidemiology and pathophysiology of CTEPH.- 2 Diagnosis of CTEPH.- 3 Pulmonary Thromboendoaterectomy: the only cure for CTEPH.- 4 Medical treatment of CTEPH.- 5 Development of Balloon Pulmonary Angioplasty in CTEPH: an historical perspective.- 6 Balloon pulmonary angioplasty in CTEPH: modern technique.- 7 Balloon pulmonary angioplasty: clinical outcomes.- 8 Lesion classification in CTEPH with an interventional perspective.- 9 Advanced non-invasive imaging to guide BPA.- 10 Use of intravascular imaging and pressure guide during BPA.- 11 Balloon pulmonary angioplasty in proximal lesions.- 12 Metrics for success of balloon pulmonary angioplasty in CTEPH.- 13 Management of complications during balloon pulmonary angioplasty in CTEPH.- 14 BPA in CTEPH: next steps?.- 15 CTEPH and chronic thromboembolic disease (CTED): clinical and interventional perspective.

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Book SynopsisThis book provides an extensive overview of the role of imaging in the detection, diagnosis, management, and follow-up of tuberculosis. Chapters cover the disease's epidemiology and pathophysiology, microbiological diagnosis and pathology relevant to radiologists, and the distinct aspects of imaging tuberculosis at various locations and body systems. This book discusses recent advances in imaging pertaining to tuberculosis, and addresses the approach to patients with tuberculosis and HIV co-infection. The final chapter offers an algorithmic approach to the diagnosis and management steps of tuberculosis. Imaging of Tuberculosis is an updated and comprehensive reference source that covers imaging of tuberculosis in a structured fashion and is valuable for radiologists.Table of ContentsPreface.- Epidemiology of Tuberculosis (TB).- Pathophysiology of TB and Microbiological Diagnosis.-. Histological Diagnosis of TB.- Imaging Techniques for TB.- Central Nervous System TB.- Head and Neck TB.- Thoracic TB.- Abdominal Solid Organ and Peritoneal TB.- Gastrointestinal TB.- Genito-urinary TB.- Spinal TB.- Musculoskeletal (Spinal) TB.- TB in AIDS.- Diagnostic Algorithm of TB.

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Book SynopsisPart I: Basic Bronchoscopy.- Tracheobronchial anatomy.- Flexible bronchoscopy.- Ultrathin bronchoscopy: indications and technique.- Rigid bronchoscopy.- Anesthesia for Interventional bronchoscopic procedures.- Evaluating outcomes  after interventional procedures.- Bronchoscopy education: Interventional Pulmonary standardization of training and education.- Part II: Interventional Procedures during the COVID-19 pandemic.- Adaptations in the Interventional Pulmonary department.- Role of bronchoscopy in COVID.- Tracheostomy in COVID.- Part III: Tracheobronchial Obstructions.- Reopening the airway: fast methods.- Cryotherapy and cryospray: applications in the airways.- Endobronchial brachytherapy.- Photodynamic therapy.- Benign Airway stenosis.- Endobronchial prosthesis: old and the new.- Part IV: Lung cancer diagnosis.- Early lung Cancer: methods for detection.- Navigation Bronchoscopy.- Robotic Bronchoscopy.- Tissue acquisition in patients with suspected lung cancer.- Lung cancerscreening: what is new.- Lung cancer epidemiologic changes: implications in diagnosis and therapy.- Patient centered care: lung cancer patients.- Part V: Lung cancer staging.- TNM classification: review and clinical implications.- Lung cancer staging methods: a practical approach.- Mediastinoscopy, its variants and transcervical mediastinal lymphadenectomy.- Endobronchial ultrasound: update.- TBNA in the endobronchial ultrasound.- Part VI: Pleural Conditions.- Pleural anatomy: a pathological and surgical perspective.- Medical thoracoscopy.- Overview of the spectrum of chest tubes with focus on the tunneled pleural catheter: disease-specific selection.- Parapneumonic effusions and empyema.- Management of malignant pleural effusion.- Transthoracic Ultrasound: role in pleural conditions.- Part VII: Interventional Bronchoscopy for specific conditions.- Emphysema: endoscopic methods for lung volume reduction.- Asthma: Bronchial thermoplasty, an update.- Evaluation of Pulmonary solitary nodule: bronchoscopy role.- Interstitial lung disease: role of diagnostic bronchoscopy.- Long term oxygen therapy: review on transtracheal oxygen catheter.- Interventional bronchoscopy in pediatric patients.- Part VIII: Interventional Procedures in critical settings.- Overview of Interventions in the ICU.- Percutaneous tracheostomy.- Foreign bodies in the airway.- Airway fistulas.- Hemoptysis: endoscopic management.- Part IX: Interventions in pulmonary medicine: history and future perspectives.- History of bronchoscopy: the evolution of interventional bronchoscopy. 

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Book SynopsisThis book aims to highlight the importance of the development of health conditions and demand for the application of noninvasive mechanical ventilation (NIMV) outside the intensive care units (ICUs); the diversification of possible scenarios outside the ICUs; the need to establish references that consolidate this phenomenon and the healthcare organizations models.In the last decades the extension of the use of NIMV outside of the ICUs has led to the generation of protocols and to the creation of new in-hospital care models. In this field, the main determining factors are a better knowledge of technique, technological advancement, better monitoring capacity, the creation of multidisciplinary teams adequately trained in their application, and social and health events that have overloaded ICUs. All these elements have promoted the creation of these NIMV units outside ICUs. This new reality entails the need for clarification of concepts, recommendations, and analysis of how to plan NIMV.Although the literature that clearly determine the indications and aids on the use of NIMV is considerable, this volume, pointing out the diversity of different healthcare models to define how to organize NIMV outside the ICUs, shed a light and bring a clear benefit to the scientific community involved.The book is structured in eleven main sections analyzing the epidemiology and trends for NIMV healthcare models and determining factors for these models outside ICUs.The originality of the work, its clear clinical-practical impact and the multidisciplinary approach given by all healthcare professionals involved (intensivists, pneumologists, internal medicine and emergency medicine specialists, geriatricians, chest respiratory therapists, etc.) is very relevant for the thoroughness of the book. Table of ContentsPart 1. Epidemiology, Rationale Equipment, Monitoring and Noninvasive Ventilation Response Outside Intensive Care Unit.- Epidemiology.- Rationale.- Clinical indications and recommendations.- Part 2. Indications for Noninvasive Mechanical ventilation outside ICU.- Classification Respiratory failure – Hypercapnic – Hypoxemic.- Noninvasive mechanical ventilation in Do not intubation order.- Comorbidities.- Part 3-Equipment and options for noninvasive ventilation outside ICU.- Options noninvasive ventilator support (NIMV, nasal high flow oxygen).- Equipments for Noninvasive mechanical ventilation.- Part 4. Monitoring Noninvasive mechanical ventilation outside ICU.- Basic monitoring.- Telemonitoring.- Part 5. Response, complications, safety, supervision, and quality indicators for NIMV outside ICU.- Risk factors failure.- Complications and prevention.- Safety recommendations.- Registration, supervision, and policies.- Quality indicators.- Part 6-Flow chart in noninvasive ventilation outside ICU.- Patients flow charts and models and NIMV: organization in hospital (pre- and beyond ICU).- Discharge planning’s from Intensive Care.- Prevention ICU-readmissions.- Part 7. Models of Noninvasive Mechanical Ventilation Units.- NIMV in the Emergency Room.- NIMV in Step Down units.- NIMV in High dependency Critical Units.- NIMV in Conventional Respiratory ward.- NIMV in Respiratory intermediate care units.- NIMV in Internal Medicine ward.- NIMV in the Perioperative medicine.- NIMV in the Endoscopic wards.- NIMV in Specialized Weaning.- NIMV in Geriatric wards.- NIMV in Hematology - Oncology departments.- NIMV Palliative care and End-stage' NIMV in respiratory rehabilitation unit.- NIMV during intra-hospital transport.- Models of NIMV in Pandemics conditions.- Models of NIMV in Bioterrorism and other catastrophic conditions.- NIMV outside ICU in low-income countries.- Part 8. Respiratory Care, Education, Ethics and Cost of NIMV Outside Intensive Care Unit.- Chest physiotherapy.- Nutrition support.- Psychologic support.- Nurse Planning and family and caregivers support.- Part 9. Education, Ethics and Cost.- Education and accreditation recommendations for NIMV outside ICU.- Ethics and palliative aspects of NIMV outside ICU.- Cost determinants.- Part 10. Noninvasive Ventilation Outside Intensive Care Unit: Discharge Plan From Hospital To Home Care.- Hospital discharge planning for patients requiring NIMV support at home.- Role Respiratory technicians in discharge program from hospital to home.- Part 11. Outcome and Long Term Follow Up in NIMV Outside ICU.- Clinical determinants hospital outcome noninvasive ventilatory support outside ICU.- Long term follow up patients receiving home NIMV.

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Book SynopsisThis atlas is designed as an easy-to-use reference guide that identifies and illustrates the key patterns of diffuse lung diseases observed on high-resolution computed tomography (HRCT) and then documents in more detail the characteristics and appearances of the individual diseases, grouped on the basis of their prevalent pattern. A further feature of the book is its interdisciplinary nature: contributions from experts in various specialties are tightly interwoven throughout and many pathologic correlations are included. Less experienced readers will find that this atlas, with its wealth of figures and helpful color coding, steers them towards correct interpretation when confronted by the multiplicity and complexity of these diseases; those who are already experts, on the other hand, will benefit from the detailed coverage of individual diseases, which will deepen their understanding. At the end of the book, a graphically appealing and practice-oriented illustrated glossary with tips and tricks offers a further highly effective educational tool. Given the clinical spectrum of diseases covered, this atlas will prove invaluable for a wide range of healthcare workers, especially radiologists, pulmonologists, and pathologists.Table of ContentsAnatomy.- Secondary Lobule.- Thinking through Pathology.- Elementary Lesions.- How to approach the Diseases.- Key HRCT Patterns.- Septal Pattern.- Fibrosing Pattern.- Nodular Pattern.- Alveolar Pattern.- Cystic Pattern.- Dark Lung Pattern.- Septal Diseases.- Fibrosing Diseases.- Nodular Diseases.- Alveolar Diseases.- Cystic Diseases.- Dark Lung Diseases.- Case-Based Glossary with Tips & Tricks.

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Book SynopsisThis book is a practical and easily understandable guide for mechanical ventilation. With a focus on the basics, this text begins with a detailed account of the mechanisms of spontaneous breathing as a reference point to then describe how a ventilator actually works and how to effectively use it in practice. The text then details: the various modes of ventilation commonly used in clinical practice; patient-ventilator interactions and dyssynchrony; how to approach a patient on the ventilator with respiratory decompensation; the optimal ventilator management for common disease states like acute respiratory distress syndrome and obstructive lung disease; the process of ventilator weaning; and hemodynamic effects of mechanical ventilation. Written for medical students, residents, and practicing physicians in a variety of different specialties (including internal medicine, critical care, surgery and anesthesiology), this book will instruct readers on how to effectively manage a ventilator, as well as explain the underlying interactions between it and the critically ill patient.Trade Review“The book is written for clinicians such as physicians, respiratory technicians, and nurses. … This book presents basic principles of mechanical ventilation essentials for clinicians working in critical care settings in a precise and easy-to-understand way. Illustrations and key points make the material easy to read and remember.” (Muhammad K Hayat Syed, Doody's Book Reviews, February, 2019)​Table of ContentsIntroduction.- Respiratory Mechanics of Spontaneous Breathing.- Phase Variables.- Basic Modes of Ventilation.- Evaluating the Patient on the Ventilator with Acute Respiratory Decompensation.- Patient-Ventilator Dyssynchrony.- Hemodynamic Consequences of Mechanical Ventilation.- Ventilator Strategies in Acute Respiratory Distress Syndrome.- Ventilator Strategies in Obstructive Lung Diseases.- Ventilator Weaning Strategies.

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Book SynopsisThis book is a comprehensive guide to our current understanding of idiopathic pulmonary fibrosis (IPF), its disease pathogenesis, genetic underpinnings, diagnosis, and management. Since the first edition, many new developments have occurred in the understanding and management of this serious disease, revising our understanding of how it presents, manifests, and reacts to certain treatments. This second edition is fully updated with six new chapters by our team of international, expert authors. New topics include: classification of interstitial lung disease, pulmonary function tests in IPF, biomarkers, clinical phenotypes, mimics, and a discussion of clinical trials. Each chapter additionally includes a brief summary of ongoing research and potential future directions. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide, Second Edition is an invaluable resource for clinicians who desire a deeper understanding of IPF in order to better help their patients.Trade Review“This is likely one of the most comprehensive and complete books on idiopathic pulmonary fibrosis currently available, and it should be extremely useful to pulmonologists and researchers who are interested in the pathogenesis, diagnosis, and treatment of this fatal disease.” (Santosh Dhungana, Doody's Book Reviews, April 26, 2019)Table of Contents1. Classification and Nomenclature of Interstitial Lung Disease 2. Epidemiology and Natural History of IPF 3. Histopathology of IPF and Related Disorders 4. Imaging of IPF 5. Pulmonary Function Tests in Idiopathic Pulmonary Fibrosis 6. The Role of Immunity & Inflammation in IPF Pathogenesis 7. Mechanisms of Fibrosis in IPF 8. The Genetics of Pulmonary Fibrosis 9. Genomics and Epigenetics of Pulmonary Fibrosis 10. Biomarkers and IPF 11. Clinical Phenotypes and Co-morbidities in IPF 12. The Keys to Making a Confident Diagnosis of IPF 13. Pharmacologic Treatment of IPF 14. Mimics of IPF 15. Gastroesophageal Reflux and IPF 16. The Role of Pulmonary Rehabilitation and Oxygen Therapy 17. Acute Exacerbations of IPF 18. Lung Transplantation for IPF 19. Clinical Trials in IPF: What Are the Best Endpoints? 20. Future Directions for IPF Research

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Book SynopsisIn diesem Buch können Eltern zusammen mit ihren erkrankten Kindern allgemeinverständliche, aber umfassende Informationen über Asthma bronchiale nachlesen und erhalten wertvolle Tipps für den Umgang mit der Erkrankung. Gespickt mit vielen Illustrationen für Kinder, erklärt das Buch alles, was sie und ihre Eltern über Asthma wissen müssen.Die Autoren klären viele alltagsrelevante Fragen und helfen damit den Erziehungsberechtigten, über die Therapie mit zu bestimmen und so zu vermeiden, dass die Lebensqualität der betroffenen Kinder vermindert ist. Dieser Asthmaratgeber berücksichtigt die neuesten Therapiekonzepte und enthält ein Asthmalexikon mit Erklärungen medizinischer Fachbegriffe sowie nützliche Adressen und Links. Table of Contents

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Book SynopsisThis book will help the reader confused by a multiplicity of diseases responsible for similar symptoms in different patients. The chapters are noticeably sign-oriented rather than disease-oriented, each dealing with one of the four cardinal modalities of HRCT presentation. Each chapter is introduced by a list of diseases, immediately followed by a detailed description of each disease, and the chapters are illustrated with enlarged images giving rhythm to the written text.Trade Review The book is well organized with color coded sections, excellent summary charts and quality coned down HRCT images illustrating the salient radiographic findings.... I found it easy to find pertinent information rapidly. I like the way the book is organized. As a radiologist, I really enjoyed the clinical and pathologic aspects included in a concise fashion. The layout and organization is quite unique compared to other texts on this subject. The authors have succeeded in making a user-friendly, thorough, and well structured guide for the evaluation of patients with diffuse lung disease. I would highly recommend this to physicians from the resident level to the specialist, including radiologists, pulmonologists, internists, and pathologists. (Michael Farah, Doody's Review) "...The size and layout of the book means that it is relatively portable and easy to read. For those radiologists who do not have the time to read the book from cover to cover, there a numerous simplified tables, incorporating disease patterns and suggested diagnoses. These act as a good quick reference guide. Overall, this is a well-written book, which serves both the interested and inexperienced reporter of HRCT. Not only does it act as a useful introduction to diffuse lung disease, but it would be an immensely valuable addition to any CT reporting bench. In addition, the book is entirely relevant to interested thoracic physicians and pathologists." (A. Devaraj, Clin radiol, December 2006) Table of ContentsAnatomy. Bronchovascular bundles. Bronchi, arteries and veins. Secondary lobule. Definition. Centrilobular interstitium. Intralobular interstitium. Perilobular interstitium. Pleural-parenchymal interface. Pleura and subpleural space.- Key Pattern: Reticular pattern. Definition. Smooth. Nodular. Irregular. Nodular pattern. Definition. Centrilobular. Random. Perilymphatic. Alveolar pattern. Definition. Mixed-density, acute. Mixed-density, chronic. Mosaic oligemia with air-trapping. Tree-in-bud. Cystic pattern. Definition. Clusters of grapes. String of pearls. Honeycombing. Random cysts.- Reticular Diseases. Amyloidosis, interstitial. Asbestosis, early. Collagen vascular diseases, early. Drug toxicity. HP, chronic. LC. NSIP. PE, interstitial. Sarcoidosis, fibrosing. UIP, early.- Nodular Diseases. HP, subacute. LCH, early. LIP. Metastases. RB-ILD. Sarcoidosis, granulomatous. Silicosis. TB, miliary. Large rounded opacities.-Alveolar Diseases. AIP. ARDS. BAC. CB. CEP. DAH. DIP. Drug toxicity. HP, acute. Infections, endobronchial. MALToma. OP. PAP. PCP. PE, alveolar.- Cystic Diseases. Asbestosis, advanced . Bronchiectasis, cystic. CF. Collagen vascular diseases, advanced. Emphisema. LAM. LCH, advanced. UIP, advanced.- Glossary.- Subject Index.-

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Book SynopsisPart 1 Epidemiology and social issues.- 1 Epidemiology of Sleep Apnea Syndrome in Adult - How much is  the prevalence of adult patients with sleep apnea at present?.- 2 Epidemiology of SAS in children - What should we know about the prevalence of patients in children with sleep apnea at present?.- 3 OSA, morphology and pathophysiology - Why is the morphology so important in the pathophysiology of obstructive sleep apnea?.- 4 Obstructive sleep apnea and lifestyle diseases - Is there a correlation between sleep apnea and lifestyle diseases?.- Part 2 Treatment and the related problems.- 5 Weight loss and positional therapy - Is it effective weight loss or positional therapy for patients with OSA.- 6 Effect of CPAP therapy on weight changes - How to understand weight changes in patients with OSA following CPAP treatment?.- 7 Comparison of oral appliance and CPAP and problems - What is the position of oral appliance for the treatment of obstructive sleep apnea?.- 8 Implantable Therapy - What is the position of implantable equipment in the treatments for OSA.- 9 Telemedicine in clinical practice of obstructive sleep apnea patients - Is the telemedicine effective in the treatment of OSA patients?.- Part 3 SAS in patients with CVD.- 10 Sleep apnea in patients with atrial fibrillation and heart failure - What should we know about the correlation between sleep apnea syndrome and AF or heart failure?.- 11 SAS in coronary artery disease and stroke - What is known about a possible association between coronary artery disease or stroke and SAS?.- Part 4 The Social issue.- 12 Use of hypnotics - Do you subscribe sleeping pills for insomnia in OSA patients?.- 13 SAS and Driving - What should we know about patients with OSAS and driving?.- Part 5 Topics.-  14 CCHS and PHOX2B - What should we know about the diagnosis and management of patients with CCHS including PHOX2B gene?.- 15 Sleep-disordered breathing associated with neuromuscular diseases - What should we know about sleep-disordered breathing in patients with  neurological disorders?.- 16 Blood pressure, nocturia, and obstructive sleep apnea - What we know about their relationships?.

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Book SynopsisThis book discusses the role of epigenetics in pathogenesis of different pulmonary diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary tuberculosis, idiopathic pulmonary fibrosis and pulmonary infections. It also explores post-translational modifications in DNA and histones for improving the understanding of lung diseases. This book helps in understanding the epigenetic mechanisms towards the development of novel diagnostic and therapeutic approaches. Further, the book provides insight into the underlying molecular mechanisms involved in the epigenetic regulation of inflammation, which may have novel implications in designing small molecule inhibitors that target the epigenetic machinery for the effective treatment of a variety of inflammation‑related diseases. This book is a valuable resource for academics, research and industry professionals working in respiratory biology.Table of ContentsChapter 1. Introduction to Lung Diseases.- Chapter 2. Introduction to Epigenetics.- Chapter 3._Epigenetic mechanisms in Inflammation.- Chapter 4. Epigenetic regulator of inflammatory gene expression.- Chapter 5. Epigenetics of Asthma.- Chapter 6_. Epigenetic optimization in chronic obstructive pulmonary disease (COPD.- Chapter 7. Epigenetics of Lung Cancer.- Chapter 8. Epigenetics of Pulmonary Tuberculosis.- Chapter 9. Epigenetics of Idiopathic Pulmonary Fibrosis.- Chapter 10. Epigenetics of influenza-A virus infection.- Chapter 11. Epigenetics of rhinovirus.- Chapter 12. Epigenetics of SARS-Cov2 (Covid-19).- Chapter 13. Epigenetics of Haemophilus Influenzae.- Chapter 14. Future Prospects and Challenges.- Chapter 15. Targeting epigenetics in pulmonary arterial hypertension. ​

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Book SynopsisTuberculosis is among the top 10 causes of death worldwide.The WHO clearly proposed that drug-resistant tuberculosis is one of the three major challenge in tuberculosis prevention and control .The book consists of detection of drug-resistant TB and its epidemics, laboratory examination for drug-resistant tubercle bacillus, pathogenic mechanism of drug-resistant TB and its diagnosis, differential diagnosis, treatment, prevention and prognosis of drug-resistant pulmonary TB. This book also focuses on the information of classic cases of drug-resistant TB, including mono-drug-resistant (including Rifampicin resistance, etc.), multidrug-resistant, poly-drug-resistant, extensive-drug-resistant (pre-extensive-drug-resistant), drug-resistant bronchial TB, and pediatric drug-resistant, as well as AIDS complicated with drug-resistant TB, and diagnosis and treatment of drug-resistant cervical TB lymphadenitis. The book also provided a comprehensive description and in-depth analysis for each selec

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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a huge range and FREE tracked UK delivery on ALL orders.

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Ultrasound is the most reliable, easily available, fast, non-invasive technique to study diaphragm function, and is an irreplaceable tool to diagnose, monitor, and follow -up critical respiratory patients. This essential guide analyses every aspect of ultrasound of the diaphragm and respiratory muscles, a reliable assessment whose function is vital to delivering the most suitable treatment. Ultrasound of the Diaphragm and the Respiratory Muscles also provides insight to diagnosing diaphragmatic dysfunction or paralysis following surgery or neuromuscular diseases, to follow the muscular activity and the time-course of atrophy during mechanical ventilation, and to monitor the weaning phase. It is ideal for professionals and trainees practicing ultrasound in a clinical setting.Key Features Sets the standard for training and competency of this emerging, yet scientifically approved non-invasive technique of ultrasound with all the essential in

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