Pre-clinical medicine: basic sciences Books

Book SynopsisAbout our authors Elaine Marieb received her Ph.D. in Zoology from the University of Massachusetts at Amherst and joined the faculty of the Biological Science Division of Holyoke Community College. While teaching at Holyoke Community College, where many of her students were pursuing nursing degrees, she developed a desire to better understand the relationship between the scientific study of the human body and the clinical aspects of nursing practice. To that end, while continuing to teach full-time, Dr. Marieb pursued her nursing education, which culminated in a Master of Science degree with a clinical specialization in gerontology from the University of Massachusetts. It is this experience that has informed the development of the unique perspective and accessibility for which her publications are known. Dr. Marieb passed away in 2018 after a lifetime of supporting numerous institutions and programs and providing local philanthropic support toTable of ContentsUNIT 1: ORGANIZATION OF THE BODY The Human Body: An Orientation Chemistry Comes Alive Cells: The Living Units Tissue: The Living Fabric UNIT 2: COVERING, SUPPORT, AND MOVEMENT OF THE BODY The Integumentary System Bones and Skeletal Tissue The Skeleton Joints Muscles and Muscle Tissue The Muscular System UNIT 3: REGULATION AND INTEGRATION OF THE BODY Fundamentals of the Nervous System and Nervous Tissue The Central Nervous System The Peripheral Nervous System and Reflex Activity The Autonomic Nervous System The Special Senses The Endocrine System UNIT 4: MAINTENANCE OF THE BODY Blood The Cardiovascular System: The Heart The Cardiovascular System: Blood Vessels The Lymphatic System and Lymphoid Organs and Tissues The Immune System: Innate and Adaptive Body Defenses The Respiratory System The Digestive System Nutrition, Metabolism, and Body Temperature Regulation The Urinary System Fluid, Electrolyte, and Acid-Base Balance UNIT 5: CONTINUITY The Reproductive System Pregnancy and Human Development Heredity

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Book SynopsisElaine Marieb received her Ph.D. in Zoology from the University of Massachusetts at Amherst and joined the faculty of the Biological Science Division of Holyoke Community College, which led to a Master of Science degree with a clinical specialisation in Gerontology from the University of Massachusetts. Dr. Marieb passed away in 2018 after a lifetime of supporting numerous institutions and programs and providing local philanthropic support to the Florida Gulf Coast University as a long-term investment in education, research, and training. Suzanne M. Keller began her teaching career while she was still in graduate school. An Iowa native, Dr. Keller uses her expertise to teach Microbiology, Anatomy, and Physiology at Indian Hills Community College, where most of her students are studying nursing or other health science programs. Dr.Keller is a member of the Human Anatomy and Physiology Society (HAPS) and the Iowa Academy of ScienceTable of ContentsBrief Contents The Human Body: An Orientation Basic Chemistry Cells and Tissues Skin and Body Membranes The Skeletal System The Muscular System The Nervous System Special Senses The Endocrine System Blood The Cardiovascular System The Lymphatic System and Body Defenses The Respiratory System The Digestive System and Body Metabolism The Urinary System The Reproductive System Appendix A: Answers to Did You Get It? Questions andMultiple Choice ReviewQuestions Appendix B: Word Roots, Prefixes, and Suffixes Appendix C: Periodic Table of theElements* Appendix D: Key Information about Vitamins and Many Essential Minerals Glossary Credits Index

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Book SynopsisElaine Marieb received her Ph.D. in Zoology from the University of Massachusetts at Amherst and joined the faculty of the Biological Science Division of Holyoke Community College, which led to a Master of Science degree with a clinical specialisation in Gerontology from the University of Massachusetts. Dr. Marieb passed away in 2018 after a lifetime of supporting numerous institutions and programs and providing local philanthropic support to the Florida Gulf Coast University as a long-term investment in education, research, and training. Suzanne M. Keller began her teaching career while she was still in graduate school. An Iowa native, Dr. Keller uses her expertise to teach Microbiology, Anatomy, and Physiology at Indian Hills Community College, where most of her students are studying nursing or other health science programs. Dr.Keller is a member of the Human Anatomy and Physiology Society (HAPS) and the Iowa Academy of Science

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Book SynopsisMedicine for MRCP provides a comprehensive review of the material that you need to pass the MRCP Parts 1 and 2 written papers. The twenty-seven chapters mapped out to the RCP syllabus, cover all areas from molecular medicine and genetics, through to medical law and ethics. Written by specialist contributors and educational experts, the content is carefully crafted to build your understanding for both papers. Each chapter begins with the basic science required for Part 1, before covering clinical medicine for Part 1, Part 2 and the PACES examinations. To ensure effective revision, material is presented in short sections with bullet lists, tables, and boxes. Over 150 drawings and photos illustrate key principles and clinical topics making them easier to retain. References to evidence-based protocols and directions to further reading allow for deeper understanding. Candidates can review their progress via the 180 end-of chapter self-assessment questions.Drawing on the authors'' expertise,Trade Review[From the foreword] The editors for this book have enrolled an extensive field of authors who are experts in their fields to provide facts which may be assimilated rapidly and that will be helpful both in revising for the MRCP examinations but also in day to day practice ... It covers aspect of medicine that ... are enormously important in everyday presentations to the acute hospital including obstetric medicine ... this work will help you in studying for the MRCP diploma but if used well will stand the reader in good stead for their future career. * Mike Jones, Consultant Acute Physician, GIRFT National Clinical Lead for Acute and General Medicine *Table of Contents1: Metabolic medicine, bone and calcuim metabolism 2: Molecular medicine and genetics 3: Clinical pharmacology and toxicology 4: Drug development and clinical trials/translational medicine 5: Radiological investigations and applications 6: Immunology 7: GU medicine and HIV 8: Infectious diseases and tropical medicine 9: Haematology 10: Principles of oncology and palliative care 11: Respiratory medicine 12: Critical care 13: Cardiology 14: Gastroenterology 15: Hepatology 16: Nephrology 17: Neurology 18: Ophthalmology 19: Diabetes and endocrinology 20: Rheumatology 21: Dermatology 22: Psychiatric disorders and their treatment 23: Obstetric medicine 24: Environmental medicine 25: Epidemiology and public health 26: Statistics 27: Medical law and ethics

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Book SynopsisTable of Contents1. The Human Body: An Orientation 2. Basic Chemistry 3. Cells and Tissues 4. Skin and Body Membranes 5. The Skeletal System 6. The Muscular System 7. The Nervous System 8. Special Senses 9. The Endocrine System 10. Blood 11. The Cardiovascular System 12. The Lymphatic System and Body Defenses 13. The Respiratory System 14. The Digestive System and Body Metabolism 15. The Urinary System 16. The Reproductive System

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Book SynopsisPart of the popular Board Review Series, BRS Cell Biology and Histology, 9th Edition distills cell biology and histology facts and concepts commonly covered on course and board exams in a portable, quick-reference format ideal for in-class learning or on-the-go review. Beautiful full-color photomicrographs and illustrations, tables, and more than 400 board-style multiple-choice review questions with answers reinforce understanding and ensure readiness for exams. Clinical Pearls, scattered throughout each chapter, emphasize the practical applications of basic science to clinical medicine and the challenges of today’s fast-paced clinical practice.    UPDATED! More than 400 board-style, multiple-choice review and clinical vignette questions—including approximately 95 new questions—reinforce essential high-yield content in clinical context. UPDATED! More than 90-question Comprehensive Exam with new expanded explanations familiarizes you with the board-style exam experience for enhanced confidence on exam day. The proven Board Review Series quick-scan outline format maximizes study time and exam preparation. Clinical Pearls emphasize the practical applications of basic science to clinical medicine. Hundreds of full-color schematic illustrations and photomicrographs, accompanied by electronic micrographs, clarify concepts and clinical details. 

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Book SynopsisDie 3., korrigierte Auflage der bewährten Einführung in die Biochemie präsentiert erneut die Schlüsselkonzepte des Faches in verständlicher Form - kompakt, anschaulich, didaktisch durchdacht. Das bestens eingeführte Lehrbuch richtet sich an Studierende der Medizin, Biologie und Chemie, die einen fundierten und leicht zugänglichen Überblick über das Gesamtgebiet der Biochemie suchen, ohne in der Fülle der modernen biochemisch-molekularbiologischen Erkenntnisse den Boden unter den Füßen zu verlieren. Dem Autor gelingt es, die Grundlagen, Leitmotive und Schlüsselkonzepte der Biochemie herauszuarbeiten und dem Leser somit das Rüstzeug für erfolgreiche Prüfungen wie auch für die spätere Vertiefung in die weiterführende Literatur zu liefern. Konzeptionell durchdacht vermittelt das Buch in fünf Teilen I: Molekulare Architektur des Lebens II: Struktur und Funktion von Proteinen III: Speicherung und Ausprägung von Erbinformation IV: Signaltr ansduktion und zelluläre FunktionV: Energiewandlung und Biosynthesenicht nur das Grundwissen der Biochemie, sondern veranschaulicht auch das Gedankengebäude dieser dynamischen Disziplin. Schlüsselbegriffe und wichtige Biomoleküle sind im Text hervorgehoben. Eine Fülle von Querverweisen schafft Zusammenhänge zwischen den Abschnitten und Kapiteln. Ausformulierte Zwischenüberschriften können als Merksätze zur schnellen Rekapitulation dienen. Maus-Symbole verweisen auf Websites, die in einer umfangreichen Link-Sammlung im Internet zur Verfügung stehen und weiterführende Informationen zu einzelnen Themen liefern. Zahlreiche Exkurse werfen Schlaglichter auf interessante biochemische und pathobiochemische Phänomene - ob es sich um die molekulare Basis menschlicher Krankheiten, wichtige Untersuchungsmethoden, spezielle Molekülstrukturen oder zellbiologische Prozesse handelt. Zur schnellen Orientierung sind die wichtigsten Biomoleküle nach Gruppen geordnet auf 15 ganzseitigen Tafeln dargestellt sowie sämtliche im Buch aufgeführten Hormone mit ihren Rezeptoren und Signalwegen als kompakte Übersicht im Tafelteil präsentiert.Eine Besonderheit des Buches sind die mehr als tausend Grafiken, die eine unverwechselbare Handschrift - plakativ, klar, verständlich - tragen und in dichter Folge die im Text vorgestellten Phänomene und Prozesse veranschaulichen.Die vorgegebenen Ausbildungsinhalte für Mediziner in der Biochemie sind durch das Buch nahezu vollständig abgedeckt. Auch das - in der neuen Approbationsordnung betonte - Zusammenwachsen von Biochemie und Molekularbiologie spiegelt sich im Buch wider.Mit diesem klar gegliederten und verständlich geschriebenen Lehrbuch macht es einfach Spaß, Biochemie zu lernen!Table of ContentsTeil I: Molekulare Architektur des Lebens1. Chemie - Basis des Lebens2. Biomoleküle - Bausteine des Lebens3. Zellen - Organisation des LebensTeil II: Struktur und Funktion von Proteinen4. Proteine - Werkzeuge der Zelle5. Ebenen der Proteinarchitektur6. Proteine auf dem Prüfstand7. Erforschung der Proteinstruktur8. Proteine als Strukturträger9. Proteine als molekulare Motoren10. Dynamik sauerstoffbindender Proteine11. Proteine als molekulare Katalysatoren12. Mechanismen der Katalyse13. Regulation der Enzymaktivität14. Enzymkaskaden des Bluts15. Evolution der ProteineTeil III: Speicherung und Ausprägung von Erbinformation16. Nucleinsäuren - Struktur und Organisation17. Transkription - Umschrift genetischer Information18. Translation - Decodierung genetischer Information19. Posttranslationale Prozessierung und Sortierung von Proteinen20. Kontrolle der Genexpression21. Replikation - Kopieren genetischer Information22. Analyse und Manipulation von Nucleinsäuren23. Veränderung genetischer InformationTeil IV: Signaltransduktion und zelluläre Funktion24. Struktur und Dynamik biologischer Membranen25. Proteine als Funktionsträger von Biomembranen26. Ionenpumpen und Membrankanäle27. Prinzipien der interzellulären Kommunikation 28. Signaltransduktion über G-Protein-gekoppelte Rezeptoren29. Signaltransduktion über enzymgekoppelte Rezeptoren30. Hormonelle Steuerung komplexer Systeme31. Molekulare Physiologie des Gastrointestinaltrakts32. Neuronale Erregung und Transmission33. Struktur und Dynamik des Cytoskeletts34. Zellzyklus und programmierter Zelltod35. Molekulare Basis von Krebsentstehung und Krebsbekämpfung36. Angeborenes und erworbenes Immunsystem37. Erforschung und Entwicklung neuer ArzneistoffeTeil V: Energiewandlung und Biosynthese38. Grundprinzipien des Metabolismus39. Glykolyse - Prototyp eines Stoffwechselwegs40. Citratzyklus - zentrale Drehscheibe des Metabolismus41. Oxidative Phosphorylierung - Elektronentransport und ATP-Synthese42. Pentosephosphatweg - ein adaptives Stoffwechselmodul43. Gluconeogenese und Cori-Zyklus44. Biosynthese und Abbau von Glykogen45. Fettsäuresynthese und ß-Oxidation46. Biosynthese von Cholesterin, Steroiden und Membranlipiden47. Abbau von Aminosäuren und Harnstoffzyklus48. Biosynthese von Aminosäuren und Häm49. Bereitstellung und Verwertung von Nucleotiden50. Koordination und Integration des Stoffwechsels

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Book SynopsisThe market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.Trade ReviewThe best general undergraduate textbook on medicinal chemistry. This new edition retains the accessible style of writing, but provides important updates on the topics. * Dr Mark Ashton, School of Pharmacy, Newcastle University, UK *I read this masterpiece to build a strong knowledge of medicinal chemistry and it has helped me a lot. I would definitely recommend it to others. Detailed explanations of enzyme-substrate interactions and much more are very useful. * Jinkal Gondaria, MChem student, Manchester Metropolitan University, UK *A very useful medical chemistry book and teaching tool. Great learning resources and easy to digest content. * Dr Silvia M.M.A. Pereira-Lima, Department of Chemistry, University of Minho, Portugal *Table of Contents1: Drugs and Drug Targets 2: Protein Structure and Function 3: Enzymes: Structure and Function 4: Receptors: Structure and Function 5: Receptors and Signal Transduction 6: Nucleic Acids: Structure and Function 7: Enzymes as Drug Targets 8: Receptors as Drug Targets 9: Nucleic Acids as Drug Targets 10: Miscellaneous Drug Targets 11: Pharmacokinetics and Related Topics Case Study 1: Statins 12: Drug Discovery: Finding a Lead 13: Drug Design: Optimizing Target Interactions 14: Drug Design: Optimizing Access to the Target 15: Getting the Drug to Market Case Study 2: The Design of ACE Inhibitors Case Study 3: Artemisinin and Related Antimalarial Drugs Case Study 4: The Design of Oxamni Case Study 5: Fosfidomycin as an Antimalarial Agent 16: Combinatorial and Parallel Synthesis 17: In Silico Drug Design 18: Quantitative Structure-Activity Relationships Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor 19: Antibacterial Agents 20: Antiviral Agents 21: Anticancer Agents 22: Protein Kinase Inhibitors as Anticancer Agents 23: Antibodies and Other Biologics 24: Cholinergics, Anticholinergics, and Anticholinestarases 25: Drugs Acting on the Adrenergic Nervous System 26: The Opioid Analgesics 27: Anti-Ulcer Agents 28: Cardiovascular Drugs Case Study 7: Steroidal Anti-Inflammatory Agents Case Study 8: Design of a Novel Antidepressant Case Study 9: The Design and Development Of Aliskiren Case Study 10: Factor Xa Inhibitors Case Study 11: Reversible Inhibitors of HCV NS-34A Protease

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Book SynopsisShortlisted for the André Simon Food & Drink Book AwardAn intoxicating interconnected history of booze and medicine, from one of the world's foremost cocktail writers.Consider the Negroni. The bittersweet cocktail dating to the early 1900s is made of equal parts gin, sweet vermouth and Campari. Gin takes its name and flavour from the juniper tree, which medieval doctors burned to ward off bubonic plague and other miasmas. Vermouth' comes from the German word for wormwood, a herb famous for its ability to rid the body of intestinal parasites. Campari is a brand of liqueur dating to 1860 with a secret recipe probably containing gentian (effective against indigestion) and rhubarb root (used as a laxative). The perfect cocktail of curative ingredients is now self-prescribed as an aperitif.The intertwined stories of medicine and alcohol stretch back to the ancient world, and involve alchemy, madness and monks, not to mention microbiology, biochemistry and germ theory. Now, in The Perfect ToTrade Review'In the last decade and a half, few people have documented or contributed more to the growth of cocktail culture than Camper English' Bartender Atlas ‘At last, a definitive guide to the medicinal origins of every bottle behind the bar! From prehistoric beer to exotic French liqueurs, a swig of alcohol has always served as tonic and treatment. With a cocktail nerd’s love of obscure ingredients and a passion for odd historical details, Camper English illuminates the murky, confounding, and even grotesque history of booze as medicine. This is the cocktail book of the year, if not the decade.’ Amy Stewart, author of The Drunken Botanist ‘A cheerfully informative highlights tour — the literary equivalent of a bowl of tasty bar snacks to consume between sips of social history … English’s inclusion of previous pandemic practices gives [The Perfect Tonic] an extra dose of insight into human nature.’ New York Times Book Review ‘A rollicking, quirky story’ Washington Post ‘With immense wit and charm, author Camper English traces millennia to explore how civilizations used fermented and distilled beverages to do everything from hydrating the workforce to fending off the Black Death. English takes a tongue-in-cheek approach to his subject matter, resulting in wildly compelling stories, such as how Buckfast, a tonic wine created by monks to treat colds and influenza, became the “U.K.'s version of Four Loko”. It is every bit as entertaining as it is educational.’ Scientific American ‘Camper English’s exploration of the medicinal history of libations is jam-packed with factoids about the history of distilling and medicine and arranged in thematic and roughly chronological order. The writing is lively and accessible, easily enjoyed by a medical anthropologist, home mixologist, or seasoned bartender.’ Science Magazine

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Book SynopsisElaine N. Marieb For Elaine N. Marieb, taking the student's perspective into account has always been an integral part of her teaching style. Dr. Marieb began her teaching career at Springfield College, where she taught anatomy and physiology to physical education majors. She then joined the faculty of the Biological Science Division of Holyoke Community College in 1969 after receiving her Ph.D. in zoology from the University of Massachusetts at Amherst. While teaching at Holyoke Community College, where many of her students were pursuing nursing degrees, she developed a desire to better understand the relationship be-tween the scientific study of the human body and the clinical aspects of the nursing practice. To that end, while continuing to teach full time, Dr. Marieb pursued her nursing education, which culminated in a Master of Science degree with a clinical specialization in gerontology from the University of Massachusetts. It is this experience that hasTable of ContentsOrientation Exercise 1. The Language of Anatomy Exercise 2. Organ Systems Overview The Microscope and Its Uses Exercise 3. The Microscope The Cell Exercise 4. The Cell: Anatomy and Division Exercise 5. The Cell: Transport Mechanisms and Cell Permeability Histology: Basic Tissues of the Body Exercise 6. Classification of Tissues The Integumentary System Exercise 7. The Integumentary System The Skeletal System Exercise 8. Overview of the Skeleton: Classification and Structure of Bones and Cartilages Exercise 9. The Axial Skeleton Exercise 10. The Appendicular Skeleton Exercise 11. Articulations and Body Movements The Muscular System Exercise 12. Microscopic Anatomy and Organization of Skeletal Muscle Exercise 13. Gross Anatomy of Muscular System Exercise 14. Skeletal Muscle Physiology: Frogs and Human Subjects The Nervous System Exercise 15. Histology of Nervous Tissue Exercise 16. Neurophysiology of Nerve Impulses: Frog Subjects Exercise 17. Gross Anatomy of the Brain and Cranial Nerves Exercise 18. Electroencephalography Exercise 19. The Spinal Cord and Spinal Nerves Exercise 20. The Autonomic Nervous System Exercise 21. Human Reflex Physiology Exercise 22. General Sensation Exercise 23. Special Senses: Anatomy of the Visual System Exercise 24. Special Senses: Visual Tests and Experiments Exercise 25: Special Senses: Hearing and Equilibrium Exercise 26. Special Senses: Olfaction and Taste The Endocrine System Exercise 27. Functional Anatomy of the Endocrine Glands Exercise 28. Endocrine Wet Labs and Human Metabolism The Circulatory System Exercise 29. Blood Exercise 30. Anatomy of the Heart Exercise 31. Conduction System of the Heart and Electrocardiography Exercise 32. Anatomy of Blood Vessels Exercise 33. Human Cardiovascular Physiology: Blood Pressure and Pulse Determinations Exercise 34. Frog Cardiovascular Physiology Exercise 35. The Lymphatic System and Immune Response The Respiratory System Exercise 36. Anatomy of the Respiratory System Exercise 37. Respiratory System Physiology The Digestive System Exercise 38. Anatomy of the Digestive System Exercise 39. Digestive System Processes: Chemical and Physical The Urinary System Exercise 40. Anatomy of the Urinary System Exercise 41. Urinalysis The Reproductive System, Development, and Heredity Exercise 42. Anatomy of the Reproductive System Exercise 43. Physiology of Reproduction: Gametogenesis and the Female Cycles Exercise 44. Survey of Embryonic Development Exercise 45. Principles of Heredity Surface Anatomy Exercise 46. Surface Anatomy Roundup PhysioEx™ 9.1 Computer Simulations Exercise 1. Cell Transport Mechanisms and Permeability Exercise 2. Skeletal Muscle Physiology Exercise 3. Neurophysiology of Nerve Impulses Exercise 4. Endocrine System Physiology Exercise 5. Cardiovascular Dynamics Exercise 6. Cardiovascular Physiology Exercise 7. Respiratory System Mechanics Exercise 8. Chemical and Physical Processes of Digestion Exercise 9. Renal System Physiology Exercise 10. Acid-Base Balance Exercise 11. Blood Analysis Exercise 12: Serological Testing The CAT version of the lab manual will each have the following additional dissection exercises: Cat Dissection Exercises Exercise 1. Dissection and Identification of Cat Muscles Exercise 2. Dissection of Cat Spinal Nerves Exercise 3. Identification of Selected Endocrine Organs of the Cat Exercise 4. Dissection of the Blood Vessels of the Cat Exercise 5. The Main Lymphatic Ducts of the Cat Exercise 6. Dissection of the Respiratory System of the Cat Exercise 7. Dissection of the Digestive System of the Cat Exercise 8. Dissection of the Urinary System of the Cat Exercise 9. Dissection of the Reproductive System of the Cat The PIG version of the lab manual will each have the following additional dissection exercises: Pig Dissection Exercises Exercise 1. Dissection and Identification of Fetal Pig Muscles Exercise 2. Dissection of the Spinal Cord and Spinal Nerves of the Fetal Pig Exercise 3. Identification of Selected Endocrine Organs of the Fetal Pig Exercise 4. Dissection of Blood Vessels and Main Lymphatic Ducts of the Fetal Pig Exercise 5. Dissection of the Respiratory System of the Fetal Pig Exercise 6. Dissection of the Digestive System of the Fetal Pig Exercise 7. Dissection of the Urinary System of the Fetal Pig Exercise 8. Dissection of the Reproductive System of the Fetal Pig

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Book SynopsisWith more than 50 real-world cases, Clinical Cases in Obstetrics, Gynaecology and Women’s Health 3e covers a range of obstetric and gynaecological problems likely to be encountered by busy junior doctors and general practitioners. Written by experienced obstetricians and gynaecologists and following the core medical school curricula in Australia, New Zealand and the United Kingdom, this pocket-sized book is an invaluable resource for medical students and clinicians. Each case presents a problem-based clinical learning scenario and then encourages readers to think about how they would take appropriate histories and examine, investigate and treat their patients. Using these techniques, students and early career doctors are guided through diagnosis and management of common and important conditions and complications. This learning is then reinforced with more than 100 multiple choice questions and answers for self-assessment.FEATURES•Problem-based learning scenarios encourage critical thinking and demonstrate effective pathways through consultation, investigation and treatment.•The ‘whole woman’ approach goes beyond clinical aspects to consider emotional, social and psychological aspects of care required.•Clinical Comments and Clinical Pearls reinforce key points and expand on important issues.NEW TO THIS EDITION•All cases revised with two NEW cases on contraception and menstrual bleeding•25 existing cases significantly revised•Focus on gender and ethnic diversity among patients and in personal situations•Updates on new treatment options•Over 100 multiple choice questions to reinforce learning from case studiesTable of ContentsPart 1Taking an obstetric or a gynecological historyConducting an examinationPart 2 Clinical Cases in General PracticeCase 1 Kate wants to talk about contraceptionCase 2 Hannah presents for a well-woman checkCase 3 Felicity is recalled after an abnormal cervical screening test reportCase 4 Mai Ling is missing school because of heavy periodsCase 5 Carrie’s periods are becoming heavierCase 6 Chloe has severe period painsCase 7 April is bothered by facial hairCase 8 Michelle still hasn’t started her periodsCase 9 Tracey and Ian are trying for a pregnancyCase 10 Sara would like to be pregnantCase 11 Lara is followed through anormal pregnancyCase 12 Stacey is unsure about having vaccinations in pregnancyCase 13 Diane has diabetes and wants to have a babyCase 14 Maria has a twin pregnancyCase 15 Anula is depressed following the birth of her babyCase 16 Emma comes for a postnatal checkCase 17 Jamie-Lee needs to know about safe sexCase 18 Miranda fears she may be pregnantCase 19 Tammy is unexpectedly pregnantCase 20 Daniela has a molar pregnancyCase 21 Ruth complains of abdominal swellingCase 22 Konstantina complains of an itchCase 23 Patricia complains of hot flushesCase 24 Debbie presents with some irregular bleedingCase 25 Alex presents with annoying menstrual bleedingPart 3 Clinical cases in obstetricsCase 26 Melissa has persistent vomiting in pregnancyCase 27 Klara has been referred to discuss prenatal diagnosisCase 28 Amy wants to try for a natural birth this timeCase 29 Louise requests a caesarean sectionCase 30 Kahlia’s baby seems smallCase 31 Maria is followed through at win pregnancyCase 32 Helen presents with raised blood pressure in pregnancyCase 33 Megan develops pre-eclampsiaCase 34 Zuzanna develops diabetes in pregnancyCase 35 Ranji has diabetes and its pregnancyCase 36 Lisa presents to the birth suite at 28 weeks of pregnancyCase 37 Su San is bleeding at 31 weeks of pregnancyCase 38 Amanda suffers a placental abruptionCase 39 Tayla presents with herpes in pregnancyCase 40 Julia has a breech presentationCase 41 Lucy’s long labour leads to further problemsCase 42 Tegan develops an obstetric emergencyCase 43 Kelly is referred to the emergency department with heavy postpartum bleedingCase 44 Ivana presents a high-risk pregnancy carePart 4 Clinical cases in gynecologyCase 45 Jenny would like a babyCase 46 Tarni presents with irregular periodsCase 47 Rebecca presents with acute abdominal painCase 48 Sharon is bleeding in early pregnancyCase 49 Angie presents with an ectopic pregnancyCase 50 Houda has an ovarian cystCase 51 Vivienne presents with abdominal painCase 52 Marilyn has postmenopausal bleedingCase 53 Barbara is bothered by ‘leaking’

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Book SynopsisTable of ContentsSection I Introduction to Cell Biology 1.Introduction to Cells 2.Evolution of Life on Earth Section II Chemical and Physical Background 3.Molecules: Structures and Dynamics 4.Biophysical Principles 5.Macromolecular Assembly 6.Research Strategies Section III Chromatin, Chromosomes, and the Cell Nucleus 7.Chromosome Organization 8.DNA Packaging in Chromatin and Chromosomes 9.Nuclear Structure and Dynamics Section IV Central Dogma: From Gene to Protein 10.Gene Expression 11.Eukaryotic RNA Processing 12.Protein Synthesis and Folding Section V Membrane Structure and Function 13.Membrane Structure and Dynamics 14.Membrane Pumps 15.Membrane Carriers 16.Membrane Channels 17.Membrane Physiology Section VI Cellular Organelles and Membrane Trafficking 18.Posttranslational Targeting of Proteins 19.Mitochondria, Chloroplasts, Peroxisomes 20.Endoplasmic Reticulum 21.Secretory Membrane System and Golgi Apparatus 22.Endocytosis and the Endosomal Membrane System 23.Processing and Degradation of Cellular Components Section VII Signaling Mechanisms 24.Plasma Membrane Receptors 25.Protein Hardware for Signaling 26.Second Messengers 27.Integration of Signals Section VIII Cellular Adhesion and the Extracellular Matrix 28.Cells of the Extracellular Matrix and Immune System 29.Extracellular Matrix Molecules 30.Cellular Adhesion 31.Intercellular Junctions 32.Connective Tissues Section IX Cytoskeleton and Cellular Motility 33.Actin and Actin-Binding Proteins 34.Microtubules and Centrosomes 35.Intermediate Filaments 36.Motor Proteins 37.Intracellular Motility 38.Cellular Motility 39.Muscles Section X Cell Cycle 40.Introduction to the Cell Cycle 41.G1 Phase and Regulation of Cell Proliferation 42.S Phase and DNA Replication 43.G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis 44.Mitosis and Cytokinesis 45.Meiosis 46.Programmed Cell Death Appendix Cell SnapShots

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Book SynopsisWritten by biomedical scientists and clinicians to disseminate the fundamental scientific principles that underpin clinical medicine, this new edition provides a clear, easily digestible account of basic cell physiology and biochemistry, and an investigation of the traditional piers of medicine.Trade ReviewReview from previous edition I have no doubt that OHMS is one of the best books I have ever bought. * Medical Student, University of Edinburgh *I would certainly recommend this book for clinical students who want to refresh some basic sciences later in their education. This is a reliable reference book which I think will serve me very well into my clinical years and I shall keep by my desk for those moments where I need to find a long-ago learnt and now-forgotten fact! * Cambridge Medicine Journal *This book represents excellent value for money and is a superb offering which is now in a mature third edition. * Dr Harry Brown, Pavilion Health Today *Table of Contents1: Cellular structure and function 2: Cellular metabolism 3: Molecular and medical genetics 4: Nerve and muscle 5: Musculoskeletal system 6: Respiratory and cardiovascular systems 7: Urinary system 8: Digestive system 9: Endocrine organs 10: Reproduction and development 11: Neuroanatomy and neurophysiology 12: Infection and immunity 13: Growth of tissues and organs 14: Medicine and society 15: Techniques of medical sciences

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Book SynopsisChan and Ridley write with an urgency...that inspires gripping depictions of what viruses are, how infectious-disease laboratories work and wonderfully lucid descriptions of bats. . . . They powerfully recount how dangerous pathogens can both leak from a lab and emerge in nature. (New York Times Book Review) Understanding how Covid-19 started is crucial for the future of humankind. Viral is the most incisive and authoritative book about the search for the source of the virus.A new virus descended on the human species in 2019 wreaking unprecedented havoc. Finding out where it came from and how it first jumped into people is an urgent priority, but early expectations that this would prove an easy question to answer have been dashed. Nearly two years into the pandemic, the crucial mystery of the origin of SARS-CoV-2 is not only unresolved but has deepened. In this uniquely insightful book, a scientist an

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Book SynopsisClaudia Neuhauser, PhD, is Associate Vice President for Research and Director of Research Computing in the Office of the Vice President for Research at University of Minnesota. In her role as Director of Research Computing she oversees the University of Minnesota Informatics Institute (UMII), the Minnesota Supercomputing Institute (MSI), and U-Spatial. UMII fosters and accelerates data-intensive research across all disciplines in the University and develops partnership with industry.  Neuhauser's research is at the interface of mathematics and biology, and focuses on the analysis of ecological and evolutionary models and the development of statistical methods in biomedical applications. She received her Diplom in mathematics from the Universität Heidelberg (Germany) in 1988, and a Ph.D. in mathematics from Cornell University in 1990. She is a fellow of the American Association for the Advancement of Science (AAAS) and a fellow of the American MathematicTable of Contents(NOTE: Each chapter concludes with Key Terms and Review Problems.) 1. Preview and Review 1.1 Precalculus Skills Diagnostic Test 1.2 Preliminaries 1.3 Elementary Functions 1.4 Graphing 2. Discrete-Time Models, Sequences, and Difference Equations 2.1 Exponential Growth and Decay 2.2 Sequences 2.3 Modeling with Recurrence Equations 3. Limits and Continuity 3.1 Limits 3.2 Continuity 3.3 Limits at Infinity 3.4 Trigonometric Limits and the Sandwich Theorem 3.5 Properties of Continuous Functions 3.6 A Formal Definition of Limits (Optional) 4. Differentiation 4.1 Formal Definition of the Derivative 4.2 Properties of the Derivative 4.3 Power Rules and Basic Rules 4.4 The Product and Quotient Rules, and the Derivatives of Rational and Power Functions 4.5 Chain Rule 4.6 Implicit Functions and Implicit Differentiation 4.7 Higher Derivatives 4.8 Derivatives of Trigonometric Functions 4.9 Derivatives of Exponential Functions 4.10 Inverse Functions and Logarithms 4.11 Linear Approximation and Error Propagation 5. Applications of Differentiation 5.1 Extrema and the Mean-Value Theorem 5.2 Monotonicity and Concavity 5.3 Extrema and Inflection Points 5.4 Optimization 5.5 L'Hôpital's Rule 5.6 Graphing and Asymptotes 5.7 Recurrence Equations: Stability (Optional) 5.8 Numerical Methods: The Newton - Raphson Method (Optional) 5.9 Modeling Biological Systems Using Differential Equations (Optional) 5.10 Antiderivatives 6. Integration 6.1 The Definite Integral 6.2 The Fundamental Theorem of Calculus 6.3 Applications of Integration 7. Integration Techniques and Computational Methods 7.1 The Substitution Rule 7.2 Integration by Parts and Practicing Integration 7.3 Rational Functions and Partial Fractions 7.4 Improper Integrals (Optional) 7.5 Numerical Integration 7.6 The Taylor Approximation (optional) 7.7 Tables of Integrals (Optional) 8. Differential Equations 8.1 Solving Separable Differential Equations 8.2 Equilibria and Their Stability 8.3 Differential Equation Models 8.4 Integrating Factors and Two-Compartment Models 9. Linear Algebra and Analytic Geometry 9.1 Linear Systems 9.2 Matrices 9.3 Linear Maps, Eigenvectors, and Eigenvalues 9.4 Demographic Modeling 9.5 Analytic Geometry 10. Multivariable Calculus 10.1 Two or More Independent Variables 10.2 Limits and Continuity (optional) 10.3 Partial Derivatives 10.4 Tangent Planes, Differentiability, and Linearization 10.5 The Chain Rule and Implicit Differentiation (Optional) 10.6 Directional Derivatives and Gradient Vectors (Optional) 10.7 Maximization and Minimization of Functions (Optional) 10.8 Diffusion (Optional) 10.9 Systems of Difference Equations (Optional) 11. Systems of Differential Equations 11.1 Linear Systems: Theory 11.2 Linear Systems: Applications 11.3 Nonlinear Autonomous Systems: Theory 11.4 Nonlinear Systems: Lotka - Volterra Model of Interspecific Interactions 11.5 More Mathematical Models (Optional) 12. Probability and Statistics 12.1 Counting 12.2 What Is Probability? 12.3 Conditional Probability and Independence 12.4 Discrete Random Variables and Discrete Distributions 12.5 Continuous Distributions 12.6 Limit Theorems 12.7 Statistical Tools Appendices A: Frequently Used Symbols B: Table of the Standard Normal Distribution Answers to Odd-Numbered Problems References Photo Credits Index

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Book SynopsisFully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers theTrade ReviewThe simple organization, the pertinent historical cues a practitioner should be looking for, the completeness of the descriptions of the physical findings, supported by the excellent graphics, makes this one of the best books on physical examination available. I highly recommend it to medical educators and medical students, residents and attendings. There is much to be learned by those at all levels of training from this well-organized, well-written book... 5 stars! * Doody's Notes *I really like it! I'll definately be referring to this one and recommending to my students. Excellent! * British Medical Association Book Awards Finalist *Table of Contents1. Communication skills ; 2. The history ; 3. General and endocrine examination ; 4. Skin, hair and nails ; 5. The cardiovascular system ; 6. The respiratory system ; 7. The abdomen ; 8. The nervous system ; 9. The eyes ; 10. The locomotor system ; 11. The ear, nose and throat ; 12. The male reproductive system ; 13. The female reproductive system ; 14. The obstetric assessment ; 15. The breast ; 16. The psychiatric assessment ; 17. The paediatric assessment ; 18. Practical procedures ; 19. Clinical data interpretation ; 20. Other investigations

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Book SynopsisTable of ContentsPart ONE PRINCIPLES OF MOLECULAR STRUCTURE AND FUNCTION 1 Chapter 1 INTRODUCTION TO BIOMOLECULES Water Is the Solvent of Life Water Contains Hydronium Ions and Hydroxyl Ions Ionizable Groups Are Characterized by Their pK Values The Blood pH is Tightly Regulated Acidosis and Alkalosis Are Common in Clinical Practice Bonds Are Formed by Reactions between Functional Groups Isomeric Forms Are Common in Biomolecules Properties of Biomolecules Are Determined by Their Noncovalent Interactions Triglycerides Consist of Fatty Acids and Glycerol Monosaccharides Are Polyalcohols with a Keto Group or an Aldehyde Group Monosaccharides Form Ring Structures Complex Carbohydrates Are Formed by Glycosidic Bonds Polypeptides Are Formed from Amino Acids Nucleic Acids Are Formed from Nucleotides Most Biomolecules Are Polymers Summary Chapter 2 INTRODUCTION TO PROTEIN STRUCTURE Amino Acids Are Zwitterions Amino Acid Side Chains Form Many Noncovalent Interactions Peptide Bonds and Disulfide Bonds Form the Primary Structure of Proteins Proteins Can Fold Themselves into Many Shapes a-Helix and ß-Pleated Sheet Are the Most Common Secondary Structures in Proteins Globular Proteins Have a Hydrophobic Core Proteins Lose Their Biological Activities When Their Higher-Order Structure Is Destroyed The Solubility of Proteins Depends on pH and Salt Concentration Proteins Absorb Ultraviolet Radiation Proteins Can Be Separated by Their Charge or Their Molecular Weight Abnormal Protein Aggregates Can Cause Disease Neurodegenerative Diseases Are Caused by Protein Aggregates Protein Misfolding Can Be Contagious Summary Chapter 3 OXYGEN TRANSPORTERS: HEMOGLOBIN AND MYOGLOBIN The Heme Group Is the Oxygen-Binding Site of Hemoglobin and Myoglobin Myoglobin Is a Tightly Packed Globular Protein Red Blood Cells Are Specialized for Oxygen Transport The Hemoglobins Are Tetrameric Proteins Oxygenated and Deoxygenated Hemoglobin Have Different Quaternary Structures Oxygen Binding to Hemoglobin Is Cooperative 2,3-Bisphosphoglycerate Is a Negative Allosteric Effector of Oxygen Binding to Hemoglobin Fetal Hemoglobin Has a Higher Oxygen-Binding Affinity than Does Adult Hemoglobin The Bohr Effect Facilitates Oxygen Delivery Most Carbon Dioxide Is Transported as Bicarbonate Summary 38 Chapter 4 ENZYMATIC REACTIONS 39 The Equilibrium Constant Describes the Equilibrium of the Reaction The Free Energy Change Is the Driving Force for Chemical Reactions The Standard Free Energy Change Determines the Equilibrium Enzymes Are Both Powerful and Selective The Substrate Must Bind to Its Enzyme before the Reaction Can Proceed Rate Constants Are Useful for Describing Reaction Rates Enzymes Decrease the Free Energy of Activation Many Enzymatic Reactions Can Be Described by Michaelis-Menten Kinetics Km and Vmax Can Be Determined Graphically Substrate Half-Life Can Be Determined for First-Order but Not Zero-Order Reactions Kcat/Km Predicts the Enzyme Activity at Low Substrate Concentration Allosteric Enzymes Do Not Conform to Michaelis-Menten Kinetics Enzyme Activity Depends on Temperature and pH Different Types of Reversible Enzyme Inhibition Can Be Distinguished Kinetically Enzymes Stabilize the Transition State Chymotrypsin Forms a Transient Covalent Bond during Catalysis Summary Chapter 5 COENZYMES Enzymes Are Classified According to Their Reaction Type Adenosine Triphosphate Has Two Energy-Rich Bonds ATP Is the Phosphate Donor in Phosphorylation Reactions ATP Hydrolysis Drives Endergonic Reactions Cells Always Try to Maintain a High Energy Charge Dehydrogenase Reactions Require Specialized Coenzymes Coenzyme A Activates Organic Acids S-Adenosyl Methionine Donates Methyl Groups Many Enzymes Require a Metal Ion Summary Part TWO GENETIC INFORMATION: DNA, RNA, AND PROTEIN SYNTHESIS Chapter 6 DNA, RNA, AND PROTEIN SYNTHESIS All Living Organisms Use DNA as Their Genetic Databank DNA Contains Four Bases DNA Forms a Double Helix DNA Can Be Denatured DNA Is Supercoiled DNA Replication Is Semiconservative DNA Is Synthesized by DNA Polymerases DNA Polymerases Have Exonuclease Activities Unwinding Proteins Present a Single-Stranded Template to the DNA Polymerases One of the New DNA Strands Is Synthesized Discontinuously RNA Plays Key Roles in Gene Expression The S Subunit Recognizes Promoters DNA Is Faithfully Copied into RNA Some RNAs Are Chemically Modified after Transcription The Genetic Code Defines the Structural Relationship between mRNA and Polypeptide Transfer RNA Is the Adapter Molecule in Protein Synthesis Amino Acids Are Activated by an Ester Bond with the 3' Terminus of the tRNA Many Transfer RNAs Recognize More than One Codon Ribosomes Are the Workbenches for Protein Synthesis The Initiation Complex Brings Together Ribosome, Messenger RNA, and Initiator tRNA Polypeptides Grow Stepwise from the Amino Terminus to the Carboxyl Terminus Protein Synthesis Is Energetically Expensive Gene Expression Is Tightly Regulated A Repressor Protein Regulates Transcription of the lac Operon in E. coli Anabolic Operons Are Repressed by the End Product of the Pathway Glucose Regulates the Transcription of Many Catabolic Operons Transcriptional Regulation Depends on DNA-Binding Proteins Summary Chapter 7 THE HUMAN GENOME Chromatin Consists of DNA and Histones The Nucleosome Is the Structural Unit of Chromatin Covalent Histone Modifications Regulate DNA Replication and Transcription DNA Methylation Silences Genes All Eukaryotic Chromosomes Have a Centromere, Telomeres, and Replication Origins Telomerase Is Required (but Not Sufficient) for Immortality Eukaryotic DNA Replication Requires Three DNA Polymerases Most Human DNA Does Not Code for Proteins Gene Families Originate by Gene Duplication The Genome Contains Many Tandem Repeats Some DNA Sequences Are Copies of Functional RNAs Many Repetitive DNA Sequences Are (or Were) Mobile L1 Elements Encode a Reverse Transcriptase Alu Sequences Spread with the Help of L1 Reverse Transcriptase Mobile Elements Are Dangerous Humans Have Approximately 20,000 Genes Transcriptional Initiation Requires General Transcription Factors Genes Are Surrounded by Regulatory Sites Gene Expression Is Regulated by DNA-Binding Proteins Long Non-coding RNAs Play Roles in Gene Expression mRNA Processing Starts during Transcription Translational Initiation Requires Many Initiation Factors mRNA Processing and Translation Are Often Regulated Small RNA Molecules Inhibit Gene Expression Mitochondria Have Their Own DNA Human Genomes Are Very Diverse Human Genomes Have Many Low-Frequency Copy Number Variations Summary Chapter 8 PROTEIN TARGETING AND PROTEOSTASIS A Signal Sequence Directs Polypeptides to the Endoplasmic Reticulum Glycoproteins Are Processed in the Secretory Pathway The Endocytic Pathway Brings Proteins into the Cell Lysosomes Are Organelles of Intracellular Digestion Autophagy Recycles Cellular Proteins and Organelles Poorly Folded Proteins Are Either Repaired or Destroyed Ubiquitin Markes Proteins for Destruction The Proteostatic System Protects Cells from Abnormal Proteins Summary Chapter 9 INTRODUCTION TO GENETIC DISEASES Four Types of Genetic Disease Mutations Occur in the Germline and in Somatic Cells Mutations Are an Important Cause of Poor Health Small Mutations Lead to Abnormal Proteins Most Mutations Are Caused by Replication Errors Mutations Can Be Induced by Radiation and Chemicals Mismatch Repair Corrects Replication Errors Missing Bases and Abnormal Bases Need to Be Replaced Nucleotide Excision Repair Removes Bulky Lesions Repair of DNA Double-Strand Breaks Is Difficult Hemoglobin Genes Form Two Gene Clusters Many Point Mutations in Hemoglobin Genes Are Known Sickle Cell Disease Is Caused by a Point Mutation in the b-Chain Gene SA Heterozygotes Are Protected from Tropical Malaria a-Thalassemia Is Most Often Caused by Large Deletions Many Different Mutations Can Cause ß-Thalassemia Fetal Hemoglobin Protects from the Effects of ß-Thalassemia and Sickle Cell Disease Summary Chapter 10 VIRUSES Viruses Can Replicate Only in a Host Cell Bacteriophage T4 Destroys Its Host Cell DNA Viruses Substitute Their Own DNA for the Host Cell DNA ? Phage Can Integrate Its DNA into the Host Cell Chromosome RNA Viruses Require an RNA-Dependent RNA Polymerase Retroviruses Replicate Through a DNA Intermediate Plasmids Are Small "Accessory Chromosomes" or "Symbiotic Viruses" of Bacteria Bacteria Can Exchange Genes by Transformation and Transduction Jumping Genes Can Change Their Position in the Genome Summary Chapter 11 DNA TECHNOLOGY Restriction Endonucleases Cut Large DNA Molecules into Smaller Fragments Large Probes Are Used to Detect Copy Number Variations Small Probes Are Used to Detect Point Mutations Southern Blotting Determines the Size of Restriction Fragments DNA Can Be Amplified with the Polymerase Chain Reaction PCR Is Used for Preimplantation Genetic Diagnosis Allelic Heterogeneity Is the Greatest Challenge for Molecular Genetic Diagnosis Normal Polymorphisms Are Used as Genetic Markers Tandem Repeats Are Used for DNA Fingerprinting DNA Microarrays Can Be Used for Genetic Screening DNA Microarrays Are Used for the Study of Gene Expression DNA Is Sequenced by Controlled Chain Termination Massively Parallel Sequencing Permits Cost-Efficient Whole-Genome Genetic Diagnosis Gene Therapy Targets Somatic Cells Viruses Are Used as Vectors for Gene Therapy Retroviruses Can Splice a Transgene into the Cell's Genome Genome Editing Is Based on the Making and Healing of DNA Double Strand Breaks Designer Nucleases Are Used for Genome Editing Antisense Oligonucleotides Can Block the Expression of Rogue Genes Genes Can Be Altered in Animals Tissue-Specific Gene Expression Can Be Engineered into Animals Human Germline Genome Editing is Technically Possible Summary Part THREE CELL AND TISSUE STRUCTURE Chapter 12 BIOLOGICAL MEMBRANES Membranes Consist of Lipid and Protein Phosphoglycerides Are the Most Abundant Membrane Lipids Most Sphingolipids Are Glycolipids Cholesterol Is the Most Hydrophobic Membrane Lipid Membrane Lipids Form a Bilayer The Lipid Bilayer Is a Two-Dimensional Fluid The Lipid Bilayer Is a Diffusion Barrier Membranes Contain Integral and Peripheral Membrane Proteins Membranes Are Asymmetrical Membranes Are Fragile Membrane Proteins Carry Solutes across the Lipid Bilayer Transport against an Electrochemical Gradient Requires Metabolic Energy Active Transport Consumes ATP Sodium Cotransport Brings Molecules into the Cell Summary Chapter 13 THE CYTOSKELETON The Erythrocyte Membrane Is Reinforced by a Spectrin Network Keratins Give Strength to Epithelia Actin Filaments Are Formed from Globular Subunits Striated Muscle Contains Thick and Thin Filaments Myosin Is a Two-Headed Molecule with ATPase Activity Muscle Contraction Requires Calcium and ATP The Cytoskeleton of Skeletal Muscle Is Linked to the Extracellular Matrix Microtubules Consist of Tubulin Eukaryotic Cilia and Flagella Contain a 9 + 2 Array of Microtubules Cells Form Specialized Junctions with Other Cells and with the Extracellular Matrix Summary Chapter 14 THE EXTRACELLULAR MATRIX Collagen Is the Most Abundant Protein in the Human Body Tropocollagen Molecule Forms a Long Triple Helix Collagen Fibrils Are Staggered Arrays of Tropocollagen Molecules Collagen Is Subject to Extensive Posttranslational Processing Collagen Metabolism Is Altered in Aging and Disease Many Genetic Defects of Collagen Structure and Biosynthesis Are Known Elastic Fibers Contain Elastin and Fibrillin The Amorphous Ground Substance Contains Hyaluronic Acid Sulfated Glycosaminoglycans Are Covalently Bound to Core Proteins Cartilage Contains Large Proteoglycan Aggregates Proteoglycans Are Synthesized in the ER and Degraded in Lysosomes Mucopolysaccharidoses Are Caused by Deficiency of Glycosaminoglycan-Degrading Enzymes Bone Consists of Calcium Phosphates in a Collagenous Matrix Basement Membranes Contain Type IV Collagen, Laminin, and Heparan Sulfate Proteoglycans Fibronectin Glues Cells and Collagen Fibers Together Summary Part FOUR MOLECULAR PHYSIOLOGY Chapter 15 EXTRACELLULAR MESSENGERS Steroid Hormones Are Made from Cholesterol Progestins Are the Biosynthetic Precursors of All Other Steroid Hormones Thyroid Hormones Are Synthesized from Protein-Bound Tyrosine T4 Becomes Activiated to T3 in the Target Tissues Both Hypothyroidism and Hyperthyroidism Are Common Disorders Insulin Is Released Together with the C-Peptide Proopiomelanocortin Forms Several Active Products Angiotensin Is Formed from Circulating Angiotensinogen Immunoassays Are Used for Determination of Hormone Levels Catecholamines Are Synthesized from Tyrosine Indolamines Are Synthesized from Tryptophan Histamine Is Produced by Mast Cells and Basophils Neurotransmitters Are Released at Synapses Acetylcholine Is the Neurotransmitter of the Neuromuscular Junction There Are Many Neurotransmitters Summary Chapter 16 INTRACELLULAR MESSENGERS Receptor-Hormone Interactions Are Noncovalent, Reversible, and Saturable Many Neurotransmitter Receptors Are Ion Channels Steroid and Thyroid Hormones Bind to Transcription Factors Seven-Transmembrane Receptors Are Coupled to G Proteins Adenylate Cyclase Is Regulated by G Proteins Hormones Can Both Activate and Inhibit the cAMP Cascade Cytoplasmic Calcium Is an Important Intracellular Signal Phospholipase C Generates Two Second Messengers Both cAMP and Calcium Regulate Gene Transcription Muscle Contraction and Exocytosis Are Triggered by Calcium Atrial Natriuretic Factor Acts through a Membrane-Bound Guanylate Cyclase Nitric Oxide Stimulates a Soluble Guanylate Cyclase cGMP Is a Second Messenger in Retinal Rod Cells Receptors for Insulin and Growth Factors Are Tyrosine-Specific Protein Kinases Growth Factors and Insulin Trigger Multiple Signaling Cascades Cytokin Receptors Use the JAK-Stat Pathway Many Receptors Become Desensitized after Overstimulation Summary Chapter 17 PLASMA PROTEINS The Blood pH Is Tightly Regulated Acidosis and Alkalosis Are Common in Clinical Practice Plasma Proteins Are Both Synthesized and Destroyed in the Liver Albumin Prevents Edema Albumin Binds Many Small Molecules Some Plasma Proteins Are Specialized Carriers of Small Molecules Deficiency of a1-Antiprotease Causes Lung Emphysema Levels of Plasma Proteins Are Affected by Many Diseases Blood Components Are Used for Transfusions Blood Clotting Must Be Tightly Controlled Platelets Adhere to Exposed Subendothelial Tissue Insoluble Fibrin Is Formed from Soluble Fibrinogen Thrombin Is Derived from Prothrombin Factor X Can Be Activated by the Extrinsic and Intrinsic Pathways Negative Controls Are Necessary to Prevent Thrombosis Plasmin Degrades the Fibrin Clot Heparin and the Vitamin K Antagonists Are Used as Anticoagulants Clotting Factor Deficiencies Cause Abnormal Bleeding Tissue Damage Causes Release of Cellular Enzymes into Blood Serum Enzymes Are Used for the Diagnosis of Many Diseases Summary Chapter 18 Defense Mechanisms Lipophilic Xenobiotics Are Metabolized to Water-soluble Products Cytochrome P-450 Is Involved in Phase I Metabolism Phase II Metabolism Makes Xenobiotics Water-Soluble for Excretion Phase III Metabolism Excretes Xenobiotic Metabolites Drug Metabolizing Enzymes Are Inducible The Innate Immune System Uses Pattern Recognitino Receptors Infection Triggers Inflammation Lymphocytes Possess Antigen Receptors B Lymphocytes Produce Immunoglobulins Antiboidies Consist of Two Light Chains and Two Heavy Chains Different Immunoglobulin Classes Have Different Properties Adaptive Immune Responses Are Based on Clonal Selection Immunoglobulin genes Are Rearranged During B-Cell Development The T-Cell Receptor Recruits Cytosolic Tyrosine Protein Kinases Mediatros of Inflammation Are Produced form Arachidonic Acid Prostaglandins Are Synthesized in All Tissues Prostanoids Participate in Many Physiological Processes Leukotrienes Are Produced by the Lipoxygenase Pathway Anti-Inflammatory Drugs Inhibit the Synthesis of Eicosanoids Summary Chapter 19 CELLULAR GROWTH CONTROL AND CANCER The Cell Cycle Is Controlled at Two Checkpoints Cells Can Be Grown in Culture Cyclins Play Key Roles in Cell Cycle Control Retinoblastoma Protein Guards the G1 Checkpoint Cell Proliferation Is Triggered by Mitogens Mitogens Regulate Gene Expression Cells Can Commit Suicide Cancers Are Monoclonal in Origin Cancer Is Caused by Activation of Growth-Promoting Genes and Inactivation of Growth-Inhibiting Genes Some Retroviruses Contain an Oncogene Retroviruses Can Cause Cancer by Inserting Themselves Next to a Cellular Proto-Oncogene Many Oncogenes Code for Components of Mitogenic Signaling Cascades Cancer Susceptibility Syndromes Are Caused by Inherited Mutations in Tumor Suppressor Genes Many Tumor Suppressor Genes Are Known Components of the Cell Cycle Machinery Are Abnormal in Most Cancers DNA Damage Causes Either Growth Arrest or Apoptosis Most Spontaneous Cancers Are Defective in p53 Action The P13K/Protein Kinase B Pathway Is Activated in Many Cancers The Products of Some Viral Oncogenes Neutralize the Products of Cellular Tumor Suppressor Genes Tumors Become More Malignant through Darwinian Selection Intestinal Polyps Are Benign Lesions Intestinal Polyps Can Evolve into Colon Cancer Summary Part FIVE METABOLISM Chapter 20 DIGESTIVE ENZYMES Saliva Contains a-Amylase and Lysozyme Protein and Fat Digestion Start in the Stomach The Pancreas Is a Factory for Digestive Enzymes Fat Digestion Requires Bile Salts Some Digestive Enzymes Are Anchored to the Surface of the Microvilli Poorly Digestible Nutrients Cause Flatulence Many Digestive Enzymes Are Released as Inactive Precursors Summary Chapter 21 INTRODUCTION TO METABOLIC PATHWAYS Alternative Substrates Can Be Oxidized in the Body Metabolic Processes Are Compartmentalized Free Energy Changes in Metabolic Pathways Are Additive Most Metabolic Pathways Are Regulated Feedback Inhibition and Feedforward Stimulation Are the Most Important Regulatory Principles Metabolism Is Regulated to Ensure Homeostasis Inherited Enzyme Deficiencies Cause Metabolic Diseases Vitamin Deficiencies, Toxins, and Endocrine Disorders Can Disrupt Metabolic Pathways Summary Chapter 22 GLYCOLYSIS, TRICARBOXYLIC ACID CYCLE, AND OXIDATIVE PHOSPHORYLATION Glucose Uptake into the Cells Is Regulated Glucose Degradation Begins in the Cytoplasm and Ends in the Mitochondria Glycolysis Begins with ATP-Dependent Phosphorylations Most Glycolytic Intermediates Have Three Carbons Phosphofructokinase Is the Most Important Regulated Enzyme of Glycolysis Lactate Is Produced under Anaerobic Conditions Pyruvate Is Decarboxylated to Acetyl-CoA in the Mitochondria The TCA Cycle Produces Two Molecules of Carbon Dioxide for Each Acetyl Residue Reduced Coenzymes Are the Most Important Products of the TCA Cycle Oxidative Pathways Are Regulated by Energy Charge and [NADH]/[NAD+] Ratio TCA Cycle Provides an Important Pool of Metabolic Intermediates Antiporters Transport Metabolites across the Inner Mitochondrial Membrane The Respiratory Chain Channels Electrons fromNADH and FADH2 to Molecular Oxygen Standard Reduction Potential Is the Tendency to Donate Electrons The Respiratory Chain Contains Flavoproteins, Iron-Sulfur Proteins, Cytochromes, Ubiquinone, and Protein-Bound Copper The Respiratory Chain Contains Large Multiprotein Complexes The Respiratory Chain Creates a Proton Gradient The Proton Gradient Drives ATP Synthesis The Efficiency of Glucose Oxidation Is Close to 40% Oxidative Phosphorylation Is Limited by the Supply of ADP Brown Adipose Tissue Contains an Uncoupling Protein Mutations in Mitochondrial DNA Can Cause Disease Summary Chapter 23 Oxygen Deficiency and Oxygen Toxicity Ischemia Leads to Infarction Oxidative Phosphorylation Is Inhibited by Many Poisons Hypoxia Inducible Factor Adjusts Cell Metabolism to Hypoxia Reactive Oxygen Derivatives Are Formed during Oxidative Metabolism The Respiratory Chain Is a Major Source of Superoxide Cells Have Specialized Enzymes to Destroy Reactive Oxygen Species Free Radical Formation Is Affected by Energy Supply and Energy Consumption Some Vitamins and Phytochemicals Can Scavange Free Radicals The NRF2 Transcription Factor Coordinates Defenses against Reactive Oxygen Species Phagocytic Cells Use Reactive Oxygen Species for Intracellular Killing Summary Chapter 24 CARBOHYDRATE METABOLISM An Adequate Blood Glucose Level Must Be Maintained at All Times Gluconeogenesis Bypasses the Three Irreversible Reactions of Glycolysis Fatty Acids Cannot Be Converted into Glucose Glycolysis and Gluconeogenesis Are Regulated by Hormones Glycolysis and Gluconeogenesis Are Fine Tuned by Allosteric Effectors and Hormone-Induced Enzyme Phosphorylations Fructose-2,6-biphosphate Switches the Liver from Gluconeogenesis to Glycolysis Glucokinase Is Regulated by Two Regulatory Proteins Carbohydrate Is Stored as Glycogen Glycogen Is 0Synthesized from Glucose Glycogen Is Degraded by Phosphorolytic Cleavage Glycogen Metabolism Is Regulated by Hormones and Metabolites Glycogen Accumulates in Several Enzyme Deficiencies Fructose Is Channeled into Glycolysis/Gluconeogenesis Excess Fructose Is Problematic Excess Galactose Is Channeled into the Pathways of Glucose Metabolism The Pentose Phosphate Pathway Supplies NADPH and Ribose-5-Phosphate Fructose Is the Principal Sugar in Seminal Fluid Amino Sugars and Sugar Acids Are Made from Glucose Summary Chapter 25 THE METABOLISM OF FATTY ACIDS AND TRIGLYCERIDES Fatty Acids Differ in Their Chain Length and Number of Double Bonds Chylomicrons Transport Triglycerides from the Intestine to Other Tissues Adipose Tissue Is Specialized for the Storage of Triglycerides Fat Metabolism in Adipose Tissue Is under Hormonal Control Fatty Acids Are Transported into the Mitochondrion ß-Oxidation Produces Acetyl-CoA, NADH, and FADH2 Special Fatty Acids Require Special Reactions The Liver Converts Excess Fatty Acids to Ketone Bodies Fatty Acids Are Synthesized from Acetyl-CoA Acetyl-CoA Is Shuttled into the Cytoplasm as Citrate Fatty Acid Synthesis Is Regulated by Hormones and Metabolites AMP-Activated Protein Kinase Adapts Metabolic Pathways to Cellular Energy Status Most Fatty Acids Can Be Synthesized from Palmitate Fatty Acids Regulate Gene Expression Polyunsaturated Fatty Acids Can Be Oxidized Nonenzymatically Summary Chapter 26 THE METABOLISM OF MEMBRANE LIPIDS 000Phosphatidic Acid Is an Intermediate in Phosphoglyceride Synthesis Phosphoglycerides Are Remodeled Continuously Sphingolipids Are Synthesized from Ceramide Deficiencies of Sphingolipid-Degrading Enzymes Cause Lipid Storage Diseases Cholesterol Is the Least Soluble Membrane Lipid Cholesterol Is Derived from Both Endogenous Synthesis and the Diet Cholesterol Biosynthesis Is Regulated at the Level of HMG-CoA Reductase Bile Acids Are Synthesized from Cholesterol Bile Acids Are Subject to Extensive Enterohepatic Circulation Most Gallstones Consist of Cholesterol Summary Chapter 27 LIPID TRANSPORT Most Plasma Lipids Are Components of Lipoproteins Lipoproteins Have Characteristic Lipid and Protein Compositions Dietary Lipids Are Transported by Chylomicrons VLDL Is a Precursor of LDL LDL Is Removed by Receptor-Mediated Endocytosis Cholesterol Regulates Its Own Metabolism HDL Is Needed for Reverse Cholesterol Transport Lipoproteins Can Initiate Atherosclerosis Lipoproteins Respond to Diet and Lifestyle Hyperlipoproteinemias Are Grouped into Five Phenotypes Hyperlipidemias Are Treated with Diet and Drugs Summary Chapter 26 AMINO ACID METABOLISM Amino Acids Can Be Used for Gluconeogenesis and Ketogenesis The Nitrogen Balance Indicates the Net Rate of Protein Synthesis The Amino Group of Amino Acids Is Released as Ammonia Ammonia Is Detoxified to Urea Urea Is Synthesized in the Urea Cycle Hyperammonemia Can Be Treated with Diet and Drugs Some Amino Acids Are Closely Related to Common Metabolic Intermediates Glycine, Serine, and Threonine Are Glucogenic Proline, Arginine, Ornithine, and Histidine Are Degraded to Glutamate Methionine and Cysteine Are Metabolically Related Valine, Leucine, and Isoleucine Are Degraded by Transamination and Oxidative Decarboxylation Phenylalanine and Tyrosine Are Both Glucogenic and Ketogenic Melanin Is Shesized from Tyrosine Lysine and Tryptophan Have Lengthy Catabolic Pathways The Liver Is the Most Important Organ of Amino Acid Metabolism Glutamine Participates in Renal Acid-Base Regulation Summary Chapter 29 METABOLISM OF IRON AND HEME Iron Is Conserved Very Efficiently in the Body Iron Uptake by Cells Is Regulated Dietary Iron Is Absorbed in the Duodenum Dietary Iron Absorption Is Regulated Iron Deficiency Is the Most Common Micronutrient Deficiency Worldwide Bone Marrow and Liver Are the Most Important Sites of Heme Synthesis Heme Is Synthesized from Succinyl-Coenzyme A and Glycine Porphyrias Are Caused by Deficiencies of Heme-Synthesizing Enzymes Heme Is Degraded to Bilirubin Bilirubin Is Conjugated and Excreted by the Liver Elevations of Serum Bilirubin Cause Jaundice Many Diseases Can Cause Jaundice Summary Chapter 30 THE METABOLISM OF PURINES AND PYRIMIDINES Purine Synthesis Starts with Ribose-5-Phosphate Purines Are Degraded to Uric Acid Free Purine Bases Can Be Salvaged Pyrimidines Are Synthesized from Carbamoyl Phosphate and Aspartate DNA Synthesis Requires Deoxyribonucleotides Many Antineoplastic Drugs Inhibit Nucleotide Metabolism Uric Acid Has Limited Water Solubility Hyperuricemia Causes Gout Abnormalities of Purine-Metabolizing Enzymes Can Cause Gout Gout Can Be Treated with Drugs Summary Chapter 31 MICRONUTRIENTS Riboflavin Is a Precursor of Flavin Mononucleotide and Flavin Adenine Dinucleotide Niacin Is a Precursor of NAD and NADP Thiamin Deficiency Causes Weakness and Amnesia Vitamin B6 Plays a Key Role in Amino Acid Metabolism Pantothenic Acid Is a Building Block of Coenzyme A Biotin Is a Coenzyme in Carboxylation Reactions Folic Acid Deficiency Causes Megaloblastic Anemia Vitamin B12 Requires Intrinsic Factor for Its Absorption Vitamin C Is a Water-Soluble Antioxidant Retinol, Retinal, and Retinoic Acid Are the Active Forms of Vitamin A Vitamin D Is a Prohormone Vitamin E Prevents Lipid Oxidation Many Vitamins and Phytochemicals Are Antioxidants Vitamin K Is Required for Blood Clotting Zinc Is a Constituent of Many Enzymes Copper Participates in Reactions of Molecular Oxygen Some Trace Elements Serve Very Specific Functions Summary Chapter 32 INTEGRATION OF METABOLISM Insulin Is Released in Response to Elevated Glucose Insulin Stimulates the Utilization of Nutrients Protein Synthesis Is Coordinated by the mTOR Complex Glucagon Maintains the Blood Glucose Level Catecholamines Mediate the Flight-or-Fight Response Glucocorticoids Are Released in Chronic Stress Energy Is Expended Continuously Stored Fat and Glycogen Are Degraded between Meals Adipose Tissue Is the Most Important Energy Depot The Liver Converts Dietary Carbohydrates to Glycogen and Fat after a Meal The Liver Maintains the Blood Glucose Level during Fasting Ketone Bodies Provide Lipid-Based Energy during Fasting Obesity Is Common in All Affluent Countries Appetite Control Is the Most Important Determinant of Obesity Obesity Is Related to Insulin Resistance Diabetes Is Caused by Insulin Deficiency or Insulin Resistance In Diabetes, Metabolism Is Regulated as in Starvation Diabetes Is Diagnosed with Laboratory Tests Diabetes Leads to Late Complications Many Drugs Are Available for Diabetes Treatment Contracting Muscle Has Three Energy Sources Catecholamines Coordinate Metabolism during Exercise Physical Exercise Leads to Adaptive Changes Ethanol Is Metabolized to Acetyl-CoA in the Liver Liver Metabolism Is Deranged by Alcohol Alcoholism Leads to Fatty Liver and Liver Cirrhosis Most "Diseases of Civilization" Are Caused by Aberrant Livestyles Aging Is the Greatest Challenge for Medical Research Anti-Aging Treatments Are Being Investigated Summary ANSWERS TO QUESTIONS GLOSSARY CREDITS EXTRA ONLINE-ONLY CASE STUDIES {more new Cases to be added, to come} The Mafia Boss Viral Gastroenteritis Death in Installments A Mysterious Death To Treat or Not to Treat? Yellow Eyes An Abdominal Emergency Shortness of Breath Itching Abdominal Pain Rheumatism A Bank Manager in Trouble Kidney Problems Gender Blender Man Overboard! Spongy Bones Blisters The Sunburned Child Too Much Ammonia ANSWERS TO CASE STUDIES

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Book SynopsisTrade Review"The book and online features constitute a very comprehensive learning tool for human embryology. This sixth edition is an excellent update of the fifth.” ©Doody's Review Service, 2022, Brian R. MacPherson, PhD (University of Kentucky College of Medicine) Doody's Score: 91 - 4 Stars!Table of ContentsIntroduction Chapter 1 Gametogenesis, Fertilization, and First Week Chapter 2 Second Week: Becoming Bilaminar and Fully Implanting Chapter 3 Third Week: Becoming Trilaminar and Establishing Body Axes Chapter 4 Fourth Week: Forming the Embryo Chapter 5 Principles and Mechanisms of Morphogenesis and Dysmorphogenesis Chapter 6 Fetal Development and the Fetus as a Patient Chapter 7 Development of the Skin and Its Derivatives Chapter 8 Development of the Musculoskeletal System Chapter 9 Development of the Central Nervous System Chapter 10 Development of the Peripheral Nervous System Chapter 11 Development of the Respiratory System and Body Cavities Chapter 12 Development of the Heart Chapter 13 Development of the Vasculature Chapter 14 Development of the Gastrointestinal Tract Chapter 15 Development of the Urinary System Chapter 16 Development of the Reproductive System Chapter 17 Development of the Pharyngeal Apparatus and Face Chapter 18 Development of the Ears Chapter 19 Development of the Eyes Chapter 20 Development of the Limbs Figure Credits

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Book SynopsisTrade Review".this book enables readers to assess knowledge and guide learning. I particularly like the summaries at the end of each chapter that allow readers to review key facts about each topic.” - ©Doody's Review Service, 2021, Gretchen Irwin, MD, MBA (University of Kansas School of Medicine - Wichita) Doody's Score: 96 - 4 Stars!Table of ContentsPart One: Principles of Family Medicine 1. The Family Physician 2. The Patient-Centered Medical Home 3. Psychosocial Influences on Health 4. Care of the Elderly Patient 5. Care of the Dying Patient 6. Care of the Self 7. Preventive Health Care 8. Behavioral Change and Patient Empowerment 9. Interpreting the Medical Literature: Applying Evidence-Based Medicine in Practice 10. Information Technology 11. Clinical Problem Solving 12. Integrative Medicine 13. Establishing Rapport 14. Interpreting Laboratory Tests Part Two: Practice of Family Medicine 15. Infectious Diseases 16. Pulmonary Medicine 17. Ophthalmology 18. Otorhinolaryngology 19. Allergy 20. Obstetrics 21. Care of the Newborn 22. Growth and Development 23. Behavioral Problems in Children and Adolescents 24. Child Abuse 25. Gynecology 26. Contraception 27. Cardiovascular Disease 28. Common Office Procedures 29. Sports Medicine 30. Common Issues in Orthopedics 31. Neck and Back Pain 32. Rheumatology and Musculoskeletal Problems 33. Dermatology 34. Diabetes Mellitus 35. Endocrinology 36. Obesity 37. Nutrition 38. Gastroenterology 39. Hematology 40. Urinary Tract Disorders 41. Neurology 42. Human Sexuality 43. Clinical Genomics 44. Crisis Intervention, Trauma, and Disasters 45. Patients with Personality Disorders; Difficult Encounters 46. Anxiety and Depression 47. Delirium and Dementia 48. Alcohol Use Disorders 49. Nicotine Addiction 50. Substance Use Disorders

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Book SynopsisTable of Contents1 Spine 2 Shoulder and Humerus 3 Elbow and Forearm 4 Wrist and Hand 5 Pelvis 6 Hip and Femur 7 Knee and Lower Leg 8 Foot and Ankle 9 Pediatrics 10 Orthlopaedic Tumors and Masses 11 Splinting and Casting 12 Wound Care and Suturing

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Book SynopsisTrade Review"As this is the first book on this topic, there are no comparable books. I highly recommend this book to anyone who is in medical education and aims to develop their learners into medical professionals who engage in self-regulated learning and develop adaptive expertise." -© Doody's Review Service, 2021, Jennifer Rockfeld, MD (University of Texas Southwestern Medical Center) Score: 100-5 Stars!Table of Contents1. Who is the Master Adaptive Learner? 2. How does Master Adaptive Learning Advance Expertise Development? 3. The Master Adaptive Learner: A Conceptual Model? 4. What are the four critical personal characteristics that support the Master Adaptive Learning process? 5. Which cognitive processes are involved in the Master Adaptive Learner process? 6. What is the role of self-assessment in the Master Adaptive Learner model? 7. How do you measure the Master Adaptive Learner? 8. How and where do I teach my students about the Master Adaptive Learner model? 9. How will the Master Adaptive Learner process work in the classroom? 10. How will the Master Adaptive Learner process work at the bedside? 11. How Does Master Adaptive Learning Interact with the Learning Environment? 12. How can I best support Master Adaptive Learners using coaching? 13. Can the Master Adaptive Learner process help the struggling learner? 14. How Can the Master Adaptive Learner Model Advance Leadership Development? 15. How Can the Master Adaptive Learner Model and Health Systems Science Collaborate to Improve Health Care? 16. How does Master Adaptive Learning ensure optimal pathways to clinical expertise?

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Book SynopsisTable of ContentsContents [draft of TOC - upon approval, I would seek additional reviews by experts on contents before finalizing, including Dr. Peter Cameron] Top 100 Secrets Section 1 History of Emergency Medical Services History of Emergency Medical Services Section 2 Emergency Medical Services Operations Destination Guidelines and Hospital Designation Emergency Vehicle Operation EMS System Design Media and Public Relations Medical Direction Medicolegal Issues Prehospital Communications Public Health and EMS Quality Improvement Research in EMS Section 3 Personal Safety and Wellness Critical Incident Stress Infectious Disease Exposure Occupational Health Issues in EMS Scene Safety Section 4 Adult Medical Care Decision making and critical interpretation of vital signs Prehospital physical assessment Abdominal pain, vomiting and diarrhea, dehydration Altered mental status Arrhythmias Cardiac arrest, including ECMO Cardiac emergencies - chest pain, STEMI, ACS, CHF Cardiac device emergencies - pacemaker/implanted defibrillator dysfunction, left ventricular assist devices Diabetic emergencies Gastrointestinal hemorrhage Hypotension and shock Infectious disease emergencies/sepsis Psychiatric emergencies/Care of the agitated or suicidal patient Obstetrics and Gynecologic emergencies Overdose Poisonings Renal failure and dialysis Respiratory emergencies - anaphylaxis, COPD, asthma, pneumonia Seizures Stroke and TIA Syncope Section 5 Adult Trauma Care General Adult trauma principles and triage Head injuries and facial trauma Cervical spine and spinal cord injuries Chest, abdominal, and pelvic injuries Extremity injuries Penetrating injuries Thermal burns and inhalational injuries Care of the entrapped patient, including crush injury Section 6 Pediatric Medical Care Decision making and critical interpretation of vital signs Abdominal pain, vomiting and diarrhea, dehydration Altered mental status Cardiac arrest and arrhythmias Chest pain and syncope Infectious disease emergencies/sepsis Prehospital physical assessment Respiratory distress emergencies - asthma, bronchiolitis, croup, pneumonia, anaphylaxis Seizures Shock Technology dependent children Poisonings Section 7 Pediatric Trauma Care General Pediatric trauma principles and triage Head injuries and facial trauma Cervical spine and spinal cord injuries Chest, abdominal, and pelvic injuries Extremity injuries Penetrating injuries Thermal burns and inhalational injuries Section 8 Disaster and Multiple Casualty Incidents General principles in disasters and multiple casualty incidents Prehospital triage for mass casualties Mass casualty evacuation and patient movement Biological terrorism Chemical terrorism Radiation and radiation injury Blast injuries Hazardous materials response Tactical EMS Search and rescue Community disaster preparedness Section 9 Wilderness EMS and Austere medicine General principles in wilderness medicine Bites, stings, and envenomations Decompression illnesses Dysbarisms Heat related illness Hypothermia Lightning and electrical emergencies Submersion injuries/drownings Wilderness survival Section 10 Special Prehospital Situations Interfacility transport, including Ground Critical Care Transport Bariatric emergencies Geriatric emergencies Aeromedical Transport Community Paramedicine Intimate partner violence, sexual assault, and child maltreatment End of life issues Section 11 Prehospital Skills and Procedures Airway Management Analgesia and sedation CPR, AED, mechanical compression Electrocardiogram interpretation Field amputation Hemorrhage control Intravascular/ interosseous access and fluids resuscitation Oxygenation and ventilation Perimortem caesarian section Point of care testing Procedures in the trauma patient Splinting and spinal immobilization Telemedicine and emerging telecommunications Termination of resuscitation Transport of the highly infectious patient

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Book SynopsisTable of ContentsPart 1 Theory 1. Concept of Value-Added Roles: Creating a Community of Practice 2. Current and Emerging Models 3. The Role of Program Evaluation in Valued-Added Medical Education: Overall Outcomes and Connections to the Assessment of Learning Part 2 Practice/Preclerkship, Clerkship, and Longitudinal Experiences 4. Students as Patient Navigators: The Penn State College of Medicine 5. Students as Patient Navigators: Case Western Reserve University School of Medicine 6. Primary Care Quality Improvement: The University of North Carolina at Chapel Hill 7. Household-Centered Service-Learning: Florida International University Herbert Wertheim College of Medicine 8. Early Medical Students as Clinical Microsystem Agents of Change-Improving Quality, Value, and the Patient Experience: University of California, San Francisco, School of Medicine 9. Plan-Do-Study-Act: Vanderbilt University School of Medicine 10. Community Health in Action: A.T. Still University's School of Osteopathic Medicine in Arizona Part 3 Implementation 11. Vision and Planning Value-Added Roles 12. Launching and Sustaining Value-Added Roles 13. Improving and Growing Value-Added Roles

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Book SynopsisTrade Review"This book is a valuable resource for busy clinicians and clinicians-in-training to assess the evidence for common medical practices. It is helpful to learn from our own practice and for medical educators to help teach the "why” of what we do in medicine.” ©Doody's Review Service, 2022, Paul D O'Rourke, MD, MPH (Johns Hopkins University School of Medicine)Table of ContentsIntroduction How to Use this Guide Chapter 1: Evidence-based Medicine Chapter 2: Cardiology Chapter 3: Pulmonology Chapter 4: Gastroenterology Chapter 5: Neurology Chapter 6: Nephrology Chapter 7: Hematology Chapter 8: Oncology Chapter 9: Infectious Diseases Chapter 10: Endocrinology Chapter 11: Psychiatry Chapter 12: Vascular Medicine & Surgery Chapter 13: Primary Care Further Reading Index

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Book SynopsisTable of ContentsIntroduction 1-Introduction II Molecules and cells 2 Amino Acids and Proteins 3- Carbohydrates and Lipids 4- Cells, Membranes and Transport. III. Metabolism 5- Hemoglobin and oxygen transport. 6- Catalytic Proteins - Enzymes 7- Coenzymes Vitamins and Minerals 8- Bioenergetics and Oxidative Metabolism 9- Anaerobic metabolism of glucose carbohydrates in the red blood cell 10-The Tricarboxylic Acid Cycle 11-Oxidative Metabolism of Lipids in Liver and Muscle 12- Biosynthesis and Storage of Carbohydrates in Liver and Muscle: Glycogen metabolism and gluconeogenesis 13- Biosynthesis and Storage of Fatty Acids 14-"Metabolism of cholesterol and steroids". 15- Biosynthesis and Degradation of Amino Acids 16- Biosynthesis and Degradation of Nucleotides. 17- Complex Carbohydrates: Glycoproteins. 18- Complex Lipids 19-The Extracellular Matrix. IV Molecular basis of inheritance 20- Deoxyribonucleic Acid. 21- Ribonucleic Acid. 22- Protein Synthesis and Turnover. 23- Regulation of Gene Expression: Basic Mechanisms 24- Fundamentals of recombinant DNA technology, molecular hybridisation and cloning 25- Genomics, Proteomics and Metabolomics. V Signalling and growth 26- Membrane Receptors and Signal Transduction 27- Neurotransmitters. 28- Biochemical Endocrinology. 29- Cellular Homeostasis: Cell Growth and Cancer. 30- Aging VI. Fuels Nutrients and Minerals 31- Digestion and Absorption of Nutrients: The Gastrointestinal Tract. 32- Glucose Homeostasis and Fuel Metabolism: Diabetes Mellitus. 33- Nutrients and diets, malnutrition and obesity 34- Lipoprotein Metabolism and Atherogenesis. VII. Specialized Tissues and Their Function. 35- The Role of Liver in Metabolism. 36- Kidney: Water and Electrolytes Homeostasis 37- Lung and the Regulation of Hydrogen Ion Concentration (Acid-Base Balance) 38- Energy Metabolism and Contraction Exercise 39- Bone Metabolism and Calcium Homeostasis. 40- Neurochemistry VIII. Blood and immunity. Clinical biochemistry. 41- Blood and Plasma Proteins. 42- Haemostasis and Thrombosis. 43- Oxidative stress and inflammation. 44-The Immune Response: Innate and adaptive immunity. Appendix - selected clinical laboratory reference ranges. Index

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Book SynopsisTable of ContentsPreface to the sixth edition Preface to the seventh edition Acknowledgements Part 1: Introducing clinical biochemistry 1 The clinical biochemistry laboratory 2 The use of the laboratory 3 Interpretation of results: general 4 Interpretation of results: diagnosis 5 Interpretation of results: monitoring 6 Analytical aspects Part 2: Core biochemistry 7 Fluid and electrolytes: basic concepts 8 Water and sodium balance: physiological mechanisms 9 Hyponatraemia: pathophysiology 10 Hyponatraemia: assessment and management 11 Hypernatraemia 12 Hyperkalaemia 13 Hypokalaemia 14 Intravenous fluid therapy 15 Investigation of renal function (1) 16 Investigation of renal function (2) 17 Urinalysis 18 Proteinuria 19 Acute kidney injury 20 Chronic kidney disease 21 Acid-base: concepts and vocabulary 22 Metabolic acid-base disorders 23 Respiratory and mixed acid-base disorders 24 Acid-base disorders: diagnosis and management 25 Proteins and enzymes 26 Immunoglobulins 27 Myocardial infarction 28 Liver function tests 29 Jaundice 30 Liver disease 31 Glucose metabolism and diabetes mellitus 32 Diagnosis and monitoring of diabetes mellitus 33 Diabetic ketoacidosis 34 Hypoglycaemia 35 Calcium regulation and hypocalcaemia 36 Hypercalcaemia 37 Phosphate and magnesium 38 Metabolic bone disease 39 Osteoporosis and fragility fractures Part 3: Endocrinology 40 Endocrine control 41 Dynamic function tests 42 Pituitary function 43 Growth disorders and acromegaly 44 Thyroid pathophysiology 45 Hypothyroidism 46 Hyperthyroidism 47 Adrenocortical pathophysiology 48 Hypofunction of the adrenal cortex 49 Hyperfunction of the adrenal cortex 50 Gonadal function 51 Subfertility Part 4: Specialised investigations 52 Nutritional assessment 53 Nutritional support 54 Parenteral nutrition 55 The metabolic response to injury 56 Gastrointestinal disorders 57 Disorders of the pancreas 58 Iron 59 Zinc and copper 60 Therapeutic drug monitoring 61 Toxicology 62 Metal poisoning 63 Alcohol 64 Ascites 65 Pleural fluid 66 Cerebrospinal fluid 67 Identification of body fluids 68 Lipoprotein metabolism 69 Clinical disorders of lipid metabolism 70 Hypertension 71 Cancer and its consequences 72 Tumour markers 73 Multiple endocrine neoplasia 74 Hyperuricaemia 75 Myopathy 76 Fetal monitoring and prenatal diagnosis 77 Pregnancy 78 Antenatal screening 79 Screening the newborn for disease 80 Paediatric biochemistry 81 Inborn errors of metabolism 82 Methods involving antibodies: immunoassay 83 Methods to separate and identify molecules 84 Selected inherited disorders Case history comments Index

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Book SynopsisTable of ContentsPart I: Phototherapeutics 1. Phototherapy: A critical review 2. Phototherapy for skin diseases 3. Phototherapy: The novel emerging treatment for cancer 4. Fundamentals of photodynamic therapy 5. Photodynamic therapy for cancer treatment 6. Photodiagnostic techniques 7. The role of physics in modern radiotherapy: Current advances and developments 8. Physics in treatment of cancer radiotherapy 9. Role of carbon ion beam radiotherapy for cancer treatment Part II: Nanotherapeutics 10. Nanomaterials physics: A critical review 11. Nanotherapeutic systems for drug delivery to brain tumors 12. Progress in nanotechnology-based targeted cancer treatment 13. Nanotherapeutics for colon cancer 14. Nanoparticles for the targeted drug delivery in lung cancer 15. Role of nanocarriers for the effective delivery of anti-HIV drugs 16. Nanoparticles for rheumatoid arthritis treatment 17. Peptide functionalized nanomaterials as microbial sensors 18. Theranostic nanoagents 19. Improving the functionality of a nanomaterial by biological probes 20. Nanostructures for the efficient oral delivery of chemotherapeutic agents 21. Photo triggered theranostics nanomaterials: Development and challenges in cancer treatment 22. Nanocrystals in the drug delivery system

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Book SynopsisThe central themes of Cell Boundaries concern the structural and organizational principles underlying cell membranes, and how these principles enable function. By building a biological and biophysical foundation for understanding the organization of lipids in bilayers and the folding, assembly, stability, and function of membrane proteins, the book aims to broaden the knowledge of bioscience students to include the basic physics and physical chemistry that inform us about membranes. In doing so, it is hoped that physics students will find familiar territory that will lead them to an interest in biology. Our progress toward understanding membranes and membrane proteins depends strongly upon the concerted use of both biology and physics. It is important for students to know not only what we know, but how we have come to know it, so Cell Boundaries endeavours to bring out the history behind the central discoveries, especially in the early chapters, where the foundation is

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Book SynopsisProteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.Chapter 2 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.Table of ContentsPreface. Contributors. The Editors. Ribosomal Pauses during Translation and Proteostasis. Protein Folding and Misfolding: Deciphering Mechanisms of Age-Related Diseases. Transcriptional Regulation of Proteostatic Mechanisms. MicroRNAs as Central Regulators of Adult Myogenesis and Proteostasis Loss in Skeletal Muscle Aging. mRNA Granules and Proteostasis in Aging and Age-Related Diseases. Phospholipids and the Unfolded Protein Response. Ubiquitin Ligases Involved in Progeroid Syndromes and Age-Associated Pathologies. Role of SUMOylation in Neurodegenerative Diseases and Inflammation. NEDD8 and Oxidative Stress. Structure, Function and Regulators of the 20S Proteasome. Cellular Responses to Proteasome Impairment. Proteasome Fate in Aging and Proteinopathies. The Proteasomal System in Cancer. Proteostasis and Skin Aging. Reactive Oxygen Species and Protein Homeostasis in Skeletal Muscle Regeneration. Protein Degradation in Cardiac Health and Disease. Autophagy in Aging and Oxidative Stress. Autophagy in Aging and Longevity Exemplified by the Aging Heart. Index.

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Book SynopsisThe Synthetic Biology Handbook explains the major goals of the field of synthetic biology and presents the technical details of the latest advances made in achieving those goals. Offering a comprehensive overview of the current areas of focus in synthetic biology, this handbook: Explores the standardisation of classic molecular bioscience approaches Addresses the societal context and potential impacts of synthetic biology Discusses the use of legacy systems as tools for new product development Examines the design and construction of de novo cells and genetic codes Describes computational methods for designing genes and gene networks Thus, the Synthetic Biology Handbook provides an accurate sense of the scope of synthetic biology today. The handbook also affords readers with an opportunity to scrutinize the underlying scTable of ContentsSynthetic Biology: Culture and Bioethical Considerations. Synthetic Biology Standards and Methods of DNA Assembly. Standardised Genetic Output Measurement. Bacterial Cells as Engineered Chassis. Eukaryotae Synthetica: Synthetic Biology in Yeast, Microalgae, and Mammalian Cells. Synthetic Plants. Theory and Construction of Semi-Synthetic Minimal Cells. Design Tools for Synthetic Biology. New Genetic Codes.

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Book SynopsisAiming to cover the major therapeutic applications of purinergic receptors and reflect the very latest developments in this area of therapeutic research, this book is authored by an international group of contributors who are authorities in the field.Table of ContentsPartial table of contents: HISTORICAL PERSPECTIVE. Purinergic Neurotransmission and Neuromodulation: A HistoricalPerspective (M. Williams & G. Burnstock). MOLECULAR PHARMACOLOGY. Adenosine Receptor Subtypes: New Insights From Cloning andFunctional Studies (G. Stiles). MEDICINAL CHEMISTRY. Development of Selective Purinoceptor Agonists and Antagonists (K.Jacobson & A. van Rhee). THERAPEUTIC IMPLICATIONS. Cardiac Electrophysiology of Adenosine: Antiarrhythmic andProarrhythmic Actions (L. Belardinelli, et al.). The Role of Adenosine in Asthma (M. Jacobson and T. Bai). Psychomotor Aspects of Adenosine Receptor Activation (M.Jarvis). Adenosine Effects in Sleep Apnea (D. Carley & M.Radulovacki). ATP in the Treatment of Cancer (E. Rapaport). Index.

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Book SynopsisTrade Review"Winner of the 2018 Francis L.K. Hsu Book Prize, Society for East Asian Anthropology of the American Anthropological Association"Table of ContentsList of Illustrations ix Acknowledgments xi 1 Introduction 1 I Online Mediations 21 Interlude: Planet Paralyzed 23 2 Mobilizing the Paralyzed Online 25 3 Cyberanatomies of Hope 49 4 Where the Virtual Becomes Visceral 73 II Chinese Experiments 99 Interlude: Ode to Olfactory Ensheathing Cells 101 5 Medical Entrepreneurs 105 6 Borderline Tactics 132 III Heterogeneous Evidence 155 Interlude: Clinical Outcomes 157 7 Seeking Truth from Facts 158 8 i-Witnessing 181 Epilogue: On the Cutting Edge 197 Glossary of Chinese Terms 207 Notes 211 Bibliography 241 Index 287

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Book SynopsisAims to update major areas of biological psychiatry and summarize important research conducted since the 1980s. This title highlights approaches that allow researchers to quantify normal and abnormal brain functions at a high level of precision.Table of ContentsContents. List of Contributors. Introduction (J. Panksepp). Emotion and Therapeutic Change (L.M. Korman and L.S. Greenberg). Emotional and Psychiatric Disorders Associated with Brain Damage (R.G. Robinson). What Functional Imaging Has Revealed about the Brain Basis of Mood and Emotion (M.S. George, T.A. Ketter, T.A. Kimbrell, J.M. Steedman, and R.M. Post). Biological Trait Markers of Depression (L.L. Davis, G.L. Kramer, A.J. Rush, and F. Petty). Sleep Abnormalities in Major Psychiatric Illnesses: Polysomnographic and Clinical Features (A.B. Douglass). Cortico-Straital Substrates of Cognitive, Motor and Sensory Gating: Speculations and Implications for Psychological Function and Dysfunction (N.R. Swerdlow). Modern Approaches to Understanding Fear: From Laboratory to Clinical Practice (J. Panksepp). Index.

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Book SynopsisWolinsky.Trade ReviewAs a model for viral evolution, this book is a gold mine. [It] should be used as a starting point for those who want to browse the huge literature on the subject... [and] to those who devise policies for the containment of the epidemic. European Molecular Biology Organization ReportsTable of ContentsContributorsPrefacePart I: Introduction to HIVChapter 1. Molecular Biology of HIVChapter 2. Global Diversity in HIVPart II: Molecular Methods For Studying HIV DiversityChapter 3. Phylogenetics and the Study of HIVChapter 4. Modeling the Molecular Evolution of HIV SequeuencesChapter 5. Statistical Approaches to Detecting Recombination Chapter 6. The Molecular Population Dynamics of HIV-1Chapter 7. Use of Phylogenetic Inference to Test an HIV Transmission HypothesisChapter 8. Coalescent Approaches to HIV Population GeneticsPart III: Case Studies of HIV EvolutionChapter 9. Levels of Diversity Within and Among Host Individuals Chapter 10. The Phylogenetics of Known Transmission HistoriesChapter 11. HIV Evolution and Disease Progression Via Longitudinal Studies Chapter 12. Perinatal HIV InfectionChapter 13. Determinants of HIV-1 Protein EvolutionChapter 14. Evolution of HIV-1 Resistance to Antiviral AgentsIndex

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Book SynopsisEthnographic analyses of emerging bioscientific enterprises in Asia, including genetically modified foods in China, clinical trials in India, and stem-cell research in Singapore, South Korea, and Taiwan.Trade Review“Asian Biotech is a thoughtful examination of Asia’s biotechnology development. The call to understand this realm in terms of situated ethics and communities of fate is persuasive and invites the analysis of more cases to test the robustness of these concepts.” - Wen-Hua Kuo, The China Quarterly“[W]hat bioethicists could learn from anthropological investigations like those presented in this volume is that one should consider the social and cultural contexts in which the practice to be ethically assessed is embedded in order to understand the the practice more thoroughly. And it is this more thorough understanding which will lead to a more nuanced and better refined ethical judgment.” - Soraj Hongladarom, Genomics, Society, and Policy“I for one would strongly recommend this interesting volume to anyone interested in gaining a better understanding of biotech in Asia.” - Krishna Ravi Srinivas, Asian Biotech and Development Review“[T]his book performs coverage of a region and a complicated sector of the twenty-frst-century economy, and it will certainly prove useful to those interested in globalized medicine and the fast-changing norms regulating research in biomedicine.” - Thomas Cannavino, Cultural Critique“This timely and important collection by science-studies scholars provides fascinating glimpses into the ambitious efforts of several Asian countries to deploy biotechnologies to both generate economic growth and provide biosecurity in this age of global science and technology.” - Doogab Yi, Chemical Heritage“The need in science studies and anthropology for Asian Biotech would be hard to overstate. I was hungry for this book to use in my own teaching and writing, and the meal is as satisfying as I had anticipated. The theoretical framing is astute and generative, and the well-argued and diverse essays are thoroughly fleshed out historically and ethnographically. Nancy N. Chen, Aihwa Ong, and the contributors deserve our thanks. We have just run out of excuses for ongoing Western parochialism in science and technology studies and all of our kindred inquiries into biotechnology.”—Donna Haraway, author of When Species Meet“This exciting collection of ethnographic essays introduces readers to the deployment of specific biotechnologies in Asia, revealing their enmeshment with local and global politics and a situated ethics that extends to the good of families, communities, and nations, and not merely that of individuals. This book, harbinger of impending futures, demands introspection.”—Margaret Lock, author of Twice Dead: Organ Transplants and the Reinvention of Death ”This is the first broad anthropological examination of the biotech movement across Asia. Especially useful are the efforts at understanding how biotechnology affects (and is affected by) major changes in moral experience and ethical imagination that are roiling Asian modernities. A pathbreaking exploration! This collection will be influential.”—Arthur Kleinman, Director, Asia Center, Harvard University“Asian Biotech is a thoughtful examination of Asia’s biotechnology development. The call to understand this realm in terms of situated ethics and communities of fate is persuasive and invites the analysis of more cases to test the robustness of these concepts.” -- Wen-Hua Kuo * The China Quarterly *“[T]his book performs coverage of a region and a complicated sector of the twenty-frst-century economy, and it will certainly prove useful to those interested in globalized medicine and the fast-changing norms regulating research in biomedicine.” -- Thomas Cannavino * Cultural Critique *“What bioethicists could learn from anthropological investigations like those presented in this volume is that one should consider the social and cultural contexts in which the practice to be ethically assessed is embedded in order to understand the the practice more thoroughly. And it is this more thorough understanding which will lead to a more nuanced and better refined ethical judgment.” -- Soraj Hongladarom * Genomics, Society and Policy *“I for one would strongly recommend this interesting volume to anyone interested in gaining a better understanding of biotech in Asia.” -- Krishna Ravi Srinivas * Asian Biotech and Development Review *“This timely and important collection by science-studies scholars provides fascinating glimpses into the ambitious efforts of several Asian countries to deploy biotechnologies to both generate economic growth and provide biosecurity in this age of global science and technology.” -- Doogab Yi * Chemical Heritage *Table of ContentsAcknowledgments Introduction: An Analytics of Ethics and Biotechnology at Multiple Scales / Aihwa Ong 1 Part I. Excess and Opportunity The Experimental Machinery of Global Clinical Trials: Case Studies from India / Kaushik Sunder Rajan 55 Feeding the Nation: Chinese Biotechnology and Genetically Modified Foods / Nancy N. Chen 81 Part II. Bioventures Asian Regeneration? Nationalism and Internationalism in Stem Cell Research in South Korea and Singapore / Charis Thompson 95 Medical Tourism in Thailand / Ara Wilson 118 Near-Liberalism: Global Corporate Citizenship and Pharmaceutical Marketing in India / Stefan Ecks 144 Part III. Communities of Fate Governing through Blood: Biology, Donation, and Exchange in Urban China / Vincanne Adams, Kathleen Erwin, and Phouc V. Le 167 Lifelines: The Ethics of Blood Banking for Family and Beyond / Aihwa Ong 190 Embryo Controversies and Governing Stem Cell Research in Japan: How to Regulate Regenerative Futures / Margaret Sleeboom-Faulkner 215 Part IV. Biosovereignty: Mappings of Chineseness Making Taiwanese (Stem Cells): Identity, Genetics, and Hybridity / Jennifer A. Liu 239 Chinese DNA: Genomics and Bionations / Wen-ching Sung 263 Afterword: Asia's Biotech Bloom / Nancy N. Chen 293 Bibliography 301 Contributors 319 Index 323

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Book SynopsisThe Metal Ions in Biological Systems series is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Written by 36 internationally recognized experts and enriched with nearly 200 illustrations, Volume 40 highlights fast moving research on lanthanides and their interrelations with biosystems and emphasizes their recent impact in biochemical and biological studies, and in medicine. Table of ContentsDistribution of the Lanthanides in the Earth's Crust; Mobilization of Lanthanides through the Terrestrial Biosphere; Complexes of Lanthanide Ions with Amino Acids, Phosphates, and Other Ligands of Biological Interest in Solution; Biologically Relevant Structural Coordination Chemistry of Simple Lanthanide Ion Complexes; Lanthanide Ions as Probes in Studies for Metal Ion-Dependent Enzymes; Lanthanide Chelates as Fluorescence Labels for Diagnostics and Biotechnology; Responsive Luminescent Lanthanide Complexes; Lanthanide Ions as Probes of Electron Transfer in Proteins; Lanthanide Ions as Luminescent Probes of Proteins and Nucleic Acids; Lanthanide-Promoted Peptide Bond Hydrolysis; Lanthanide-Catalyzed Hydrolysis of Phosphate Esters and Nucleic Acids; Sequence-Selective Scission of DNA and RNA by Lanthanides and Their Complexes; Lanthanide Ions as Probes for Metal Ions in the Structure and Catalytic Mechanism of Ribozymes; Lanthanides as Shift and Relaxation Agents in Elucidating the Structure of Proteins and Nucleic Acids; Lanthanide Ions as Magnetic Resonance Imaging Agents. Nuclear and Electronic Relaxation Properties. Applications; Interactions of Lanthanides and Their Complexes with Proteins. Conclusions Regarding Magnetic Resonance Imaging.

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