Pharmacology Books

Book SynopsisThis book is aimed at those in the biomedical community that are interested in the therapeutic applications, pharmacology, biochemistry, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram (Antabuse®) regimens that allow alcoholics to achieve abstinence of many months' duration have made writing this book an exciting experience. At the same time the fact that the two drugs differ substantially in their pharmacological effects in spite of their easy interconvertibility has rendered the writing intellec­ tually challenging. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper­ ties. Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear. The drug is also a potent chelator of heavy metals and this has led to a number of clinical applications. As might be expected, it inhibits several important enzymes. Further, it is one of the most effective radioprotective agents; it also protects organisms against a variety of toxic agents.Trade Review...a well written, detailed publication on literally everything the reader would wish to know about disulfiram and its metabolite - British Journal of Psychiatry; This well written and carefully edited volume deserves the interest of toxicologists, pharmacologists, immunologists, biochemists and clinicians. Journal of Applied Toxicology; It is hoped that clinicians and behavioral scientists have read this book for their own education and also to appreciate the advances made in the biochemical pharmacology of DSSD and SSH. This book should capture the interest of medicinal chemists and pharmacologists who are engaged in research in cancer, immunomodulation, HIV, and heavy metal toxicity. Selected chapters are must reading for biomedical scientists pursuing alcoholism research. Journal of Medicinal ChemistryTable of ContentsIntroduction and scope of monograph. Relevant chemical and physical properties. Reactions of disulfiram and diethyldithiocarbamate with blood constituents. Assay methods for disulfiram and metabolites in biological materials. Metabolism of disulfiram and diethyldithiocarbamate. Pharmacokinetic aspects of the disposition of disulfiram and metabolites. Heavy metals: effects of diethyldithiocarbamate and disulfiram administration. Disulfiram and diethyldithiocarbamate as enzyme inhibitors. Inhibition of aldehyde dehydrogenase. The disulfiram-ethanol reaction. Disulfiram therapy of alcohol abuse. Various biological phenomena. Immunomodulatory actions of diethyldithiocarbamate. Clinical status of diethyldithiocarbamate as an immunostimulant. Modulation of various biological phenomena. Modulation of cancer chemotherapy. Toxicology. Bibliography. Index.

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Book SynopsisMany drugs used in current anesthetic practice are administered intravenously. An appreciation of their kinetics and dynamics is of great assistance in determining the most appropriate drug to use, and optimal dosage regimens for any given patient. This book is specially oriented to the requirements of anesthesiologists. It will enable the student of those subjects to gain enough knowledge to make these subjects usable in daily anesthetic practice. As such it is intermediate in difficulty between mathematically oriented texts, and those which only offer a very qualitative understanding of these subjects. Practical applications and examples of the uses to which kinetic and dynamic principles can be put in daily practice are emphasized and illustrated. Basic principles and techniques with which the reader can perform kinetic and dynamic calculations are explained simply and demonstrated in detail using examples derived from clinical practice. Two appendices provide kinetic and dynamic data on the most commonly used anesthetic drugs. The last chapters use the principles discussed in the first chapters to show how variations of normal physiology and disease affect drug kinetics and dynamics. This is especially valuable to the clinician as it enables clinically useful, albeit qualitative, predictions to be made of the direction of any change of kinetic and dynamic parameters of drugs due to these factors. Table of ContentsIntroduction. 1. Basic Mathematical Principles. 2. Physiological Aspects of Drug Kinetics and Dynamics. 3. Multicompartment Pharmacokinetic Models. 4. Pharmacodynamics. 5. Practical I. V. Bolus Kinetics & Dynamics. 6. Intravenous Infusions. 7. Body Weight and Composition. 8. Plasma Protein Binding. 9. Cardiac Output. 10. Age. 11. Obesity. 12. Pregnancy Related Problems. 13. Renal Failure. 14. Hepatic Dysfunction. Appendix A: Kinetic and Dynamic Parameters. Appendix B: Physical and Pharmacological Properties. Index.

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Book SynopsisChapter 1. Introduction to ethnobotany and traditional medicine.- Chapter 2. Evolution of traditional resources and their uses in the field of drug discovery: its present-day impact in society.- Chapter 3. Different tools for modern drug discovery research.- Chapter 4. Phytopharmaceutical drugs from traditional resources.- Chapter 5. Importance of traditional knowledge in modern drug discovery.- Chapter 6. The importance of traditional resources in ethnomedicine.- Chapter 7. Role of Ethnomedicinal resources as therapeutic agents in modern drug development.- Chapter 8. Impact of medicinal plants on modern drug discovery.- Chapter 9.  Importance of biomarkers from natural resources in modern drug discovery.- Chapter 10. Role of metabolomics from traditional resources in modern drugs.- Chapter 11. Importance of Reverse pharmacology from ethnomedicinal studies in drug discovery.-Chapter 12. Poly-pharmacological approach in the study of ethnomedicinal compounds and drug discovery.-Chapter 13. Nutraceutical approach from natural plant-based resources and their significance in modern drugs.-Chapter 14. The importance of natural products in drug discovery opportunities and success.-Chapter 15. The ethnomedicinal value of traditional medicinal herbs.-Chapter 16. Importance of traditional resources in Pharmacological industries.-Chapter 17. Role of ethnomedicinal resources in curing metabolic diseases.-Chapter 18. Modern drug research and its impact on pharmacological industries.-Chapter 19. Economic benefits of natural products concerning modern drug discovery in the 21st century.-Chapter 20. Economic importance of traditional medicinal resources.-Chapter 21. The market value of traditionally used medicinal plants.

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Book SynopsisChapter 1. PEGylated Pharmaceutical Nanocarriers.- Chapter 2. Methods and Protocols for the synthesis of PEGylated Pharmaceutical Nanocarriers.- Chapter 3. Topology and internal structure of PEGylated nanocarriers.- Chapter 4. PEGylated Nanocarriers for Drug delivery applications.- Chapter 5. PEGylated Nanocarriers for Solubilization.- Chapter 6. PEGylation as a tool to alter immunological properties of Nanocarriers.- Chapter 7. PEGylated nanocarrier as a promising tool for site-specific delivery of therapeutics.- Chapter 8. PEGylated Nanocarriers for Gene delivery.- Chapter 9. PEGylated Nanocarrier system for nucleic acid delivery.- Chapter 10. PEGylated Nanocarriers for protein and peptide delivery.- Chapter 11. PEGylation of protein and peptides.- Chapter 12. PEGylated nanocarriers for diagnostic applications.- Chapter 13. Multifunctional PEGylated nanocarriers in theragnosis.- Chapter 14. Reversible PEGylation of nanocarriers.- Chapter 15. Stimuli responsive PEGylated Nanocarriers.- Chapter 16. Beyond PEGylation PEGylation and its alternatives..- Chapter 17. Current status and Regulatory Aspects of PEGylated Nanoproducts.- Chapter 18. Medicinal and Pharmaceutical Applications of PEGylated Nanocarriers.

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Book SynopsisAdvances in Development of Pharmaceutical Products.- Design of Materials and Product Specifications for Pharmaceutical Dosage Forms.- Optimization Techniques for Development of Pharmaceutical Products.- Pharmaceutical Product Development: Formulation Additives.- Advances in Pharmaceutical Oral Solid Dosage Forms.-Advances in Tablet Production and Tablet Coating.- Formulation Evaluation and Development of Specialized Tablets.- Suspensions: Theory, Formulation, Considerations, Flocculated and Deflocculated Suspensions, Evaluation of Suspension Stability.- Liquid and poly-disperse systems: Emulsions.- Sterile Products and Admixtures.- Challenges and Advances in Pharmaceutical Development of Topical and Transdermal Dosage Forms.- Advances in Ophthalmic Formulations Development.- Advances and Developments in Formulation of Drug Nanocrystals.- A Technological Update on Inhalation Drug Delivery Devices.- Herbal Formulations: Development, Challenges, Testing, Stability, and Regulatory Guidelines.- Drug Repurposing and Virtual Screening.- Preclinical and Clinical Studies, Pharmacovigilance, Pharmacogenomics, and Commercialization of Pharmaceutical Products.

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