Pharmacology Books

Book SynopsisPhytochemical research took shape with the isolation of morphine by F.W. Seturner in 1805. This book includes about 290 phytopharmaceuticals giving their characterization and structure elucidation by modern instrumental methods like UV, IR, HNMR 13C NMR, Ms, HRMS, X-Ray, biosynthesis and synthesis. The book though written for M.Pharm. Pharmacognosy will, however, also found useful as a reference by researchers in natural product chemistry in ICMR units, National Laboratories and pharmaceutical industry the world over.Table of Contents 1. Terpenoids 8. Vitamins and Other Health Products 2. Steroids 9. Antibiotics 3. Flavonoids 10. Lipids 4. Alkaloids 11. Carbohydrates 5. Proteins and Polypeptides 12. Toxins (Aflatoxins) 6. Nucleic Acids 13. Marine Agents 7. Lipoproteins and Amino -Acids

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Book SynopsisGallery of Medicinal Plants (Dravyaguna Vigyan) is an excellent book in its field Ayurvedic Materia Medica which covers all medicinal plants and drugs of animal-origin included in Paper-II of Dravyaguna Vigyan, as per the Central Council of Indian Medicine (CCIM) syllabus. Not only is this book a monograph, but it also serves as a color atlas of medicinal plants. It will be an immensely valuable resource for the students, faculty, academicians, and researchers in Ayurveda, homeopathy, Unani, Siddha, botany, pharmacy, medicinal plants, and other related branches of study at both undergraduate and postgraduate levels. Key Features: Emphasis is laid on the identification of different plants, as the book contains 1000+ colored images of parts of an individual plant The chapters discuss histological, mythological, and spiritual data along with the controversial aspects of medicinal plants Key characters for identification, rasapanchak (Ayurvedic properties), points to ponder, etc. are placed in colored boxes for easy remembrance Folklore and ethnopharmacological uses, own experience, and recent research data are given in addition to classical information Frequently asked questions are also appended at the end of the book Table of ContentsPart I: Detailed Plants Part II: Nondetailed Plants Part III: Jangama Dravya (Drugs of Animal Origin) Part IV: Ahara Dravya

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Book SynopsisThis book is aimed at those in the biomedical community that are interested in the therapeutic applications, pharmacology, biochemistry, toxicology and pharmacokinetics of the title compounds. Recent findings regarding the ability of diethyldithiocarbamate (ditiocarb, Imuthiol®) to delay the progression of HN infections and AIDS, the discovery of its potential as a rescue agent in cancer chemotherapy, and the identification of disulfiram (Antabuse®) regimens that allow alcoholics to achieve abstinence of many months' duration have made writing this book an exciting experience. At the same time the fact that the two drugs differ substantially in their pharmacological effects in spite of their easy interconvertibility has rendered the writing intellec­ tually challenging. Diethyldithiocarbamate, an agent seemingly less toxic than aspirin, rivals it in the multiplicity and diversity of its pharmacological proper­ ties. Notable among these are the manyfold potent immunostimulant effects, and though most of these involve effects on T -cells, the mechanism of diethyldithiocarbamate's action remains far from clear. The drug is also a potent chelator of heavy metals and this has led to a number of clinical applications. As might be expected, it inhibits several important enzymes. Further, it is one of the most effective radioprotective agents; it also protects organisms against a variety of toxic agents.Trade Review...a well written, detailed publication on literally everything the reader would wish to know about disulfiram and its metabolite - British Journal of Psychiatry; This well written and carefully edited volume deserves the interest of toxicologists, pharmacologists, immunologists, biochemists and clinicians. Journal of Applied Toxicology; It is hoped that clinicians and behavioral scientists have read this book for their own education and also to appreciate the advances made in the biochemical pharmacology of DSSD and SSH. This book should capture the interest of medicinal chemists and pharmacologists who are engaged in research in cancer, immunomodulation, HIV, and heavy metal toxicity. Selected chapters are must reading for biomedical scientists pursuing alcoholism research. Journal of Medicinal ChemistryTable of ContentsIntroduction and scope of monograph. Relevant chemical and physical properties. Reactions of disulfiram and diethyldithiocarbamate with blood constituents. Assay methods for disulfiram and metabolites in biological materials. Metabolism of disulfiram and diethyldithiocarbamate. Pharmacokinetic aspects of the disposition of disulfiram and metabolites. Heavy metals: effects of diethyldithiocarbamate and disulfiram administration. Disulfiram and diethyldithiocarbamate as enzyme inhibitors. Inhibition of aldehyde dehydrogenase. The disulfiram-ethanol reaction. Disulfiram therapy of alcohol abuse. Various biological phenomena. Immunomodulatory actions of diethyldithiocarbamate. Clinical status of diethyldithiocarbamate as an immunostimulant. Modulation of various biological phenomena. Modulation of cancer chemotherapy. Toxicology. Bibliography. Index.

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Book SynopsisThe purpose of this book is to clarify the use of antibiotics in the management of the eommon respiratory illnesses seen in general practiee. The underlying philosophy, whieh embraees the avoidanee of unneeessary use, is that proper use entails a full understanding of the nature of the illness. The eoneept of seleetive antibiotie use reeognizes that respiratory illnesses eommonly eomprise multiple illness features, and that some of these features have a viral cause and some a bacterial one. In assessing antibiotic need, eaeh feature or eomponent part of an illness may be evaluated individually, so enabling adecision for antibiotie use in the illness as a whole. The nature of eaeh individual illness feature with its antibiotic indication is diseussed in sueeessive ehapters, and this aecumulated knowledge is of value in managing the more eomplex PUO and flu-like illnesses whieh are diseussed at the end of the book. The first two ehapters eneompass the principles of antibiotic use and the relationship between antibiotie preseribing and various states of the patient, e.g. allergy, pregnaney ete. An attempt has been made to justify every reeommendation or decision, and non-antibiotic management is diseussed where relevant.Table of Contents1 Antibiotics and the Patient.- Allergy.- Antibiotic Diarrhoea.- The Contraceptive Pill.- Pregnancy.- Lactation.- Neonates.- Children.- The Elderly.- Hepatic and Renal Impairment.- Drug Interactions.- Absorption.- 2 Management Principles.- 3 Pyrexia.- Febrile Convulsions.- Delirium.- Rigors.- Symptomatic Management of Pyrexia.- Antibiotic Use.- 4 Sore Throat, Tonsillitis and Pharyngitis.- Definition.- The Non-inflamed Sore Throat.- The Inflamed Throat.- Referral for Tonsillectomy.- 5 Otitis Media.- Use of the Auroscope.- Clinical Features of Acute Otitis Media.- Bacteria in Acute Otitis Media.- Secretory Otitis Media.- Management and Antibiotic Use.- Chronic Otitis Media.- 6 Sinusitis.- Clinical Features.- Bacteriology.- Management and Antibiotic Use.- 7 Laryngitis.- Croup.- Hoarseness or Loss of Voice.- 8 Coughs and Colds.- The Acute Cough.- Cold in the Nose.- Persistent Cough in Children.- Persistent Cough in Adults.- The Absent Cough.- 9 Wheezy Bronchitis in Children.- The Nature of Wheezy Bronchitis.- Recognition of Asthma.- Management of the Acute Episode.- Longerterm Management.- Differential Diagnosis.- 10 Pneumonia.- Clinical Diagnosis.- Investigation.- Infective Causes.- Management and Antibiotic Use.- Differential Diagnosis.- 11 Bronchitis, Bronchiolitis and Bronchiectasis.- Acute Bronchitis.- Acute Bronchiolitis.- Chronic Bronchitis.- Bronchiectasis.- 12 Vomiting and Diarrhoea.- Non-specific Vomiting.- Gastro-enteritis.- Management.- 13 PUO in Children.- Definition.- Emergent Diagnoses.- Management and Antibiotic Use.- 14 Influenza and the ’Flu-like Illness.- The Influenzal Illness.- Viral Causes.- Differential Diagnosis.- Clinical Assessment of the Patient with ’Flu.- Management and Antibiotic Use.

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Book SynopsisMany drugs used in current anesthetic practice are administered intravenously. An appreciation of their kinetics and dynamics is of great assistance in determining the most appropriate drug to use, and optimal dosage regimens for any given patient. This book is specially oriented to the requirements of anesthesiologists. It will enable the student of those subjects to gain enough knowledge to make these subjects usable in daily anesthetic practice. As such it is intermediate in difficulty between mathematically oriented texts, and those which only offer a very qualitative understanding of these subjects. Practical applications and examples of the uses to which kinetic and dynamic principles can be put in daily practice are emphasized and illustrated. Basic principles and techniques with which the reader can perform kinetic and dynamic calculations are explained simply and demonstrated in detail using examples derived from clinical practice. Two appendices provide kinetic and dynamic data on the most commonly used anesthetic drugs. The last chapters use the principles discussed in the first chapters to show how variations of normal physiology and disease affect drug kinetics and dynamics. This is especially valuable to the clinician as it enables clinically useful, albeit qualitative, predictions to be made of the direction of any change of kinetic and dynamic parameters of drugs due to these factors. Table of ContentsIntroduction. 1. Basic Mathematical Principles. 2. Physiological Aspects of Drug Kinetics and Dynamics. 3. Multicompartment Pharmacokinetic Models. 4. Pharmacodynamics. 5. Practical I. V. Bolus Kinetics & Dynamics. 6. Intravenous Infusions. 7. Body Weight and Composition. 8. Plasma Protein Binding. 9. Cardiac Output. 10. Age. 11. Obesity. 12. Pregnancy Related Problems. 13. Renal Failure. 14. Hepatic Dysfunction. Appendix A: Kinetic and Dynamic Parameters. Appendix B: Physical and Pharmacological Properties. Index.

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Book SynopsisCompletely revised and updated, Cobert's Manual of Drug Safety and Pharmacovigilance, Third Edition, is a how-to manual for those working in the fields of drug safety, clinical research, pharmacology, regulatory affairs, risk management, quality/compliance, and in government and legal professions.This comprehensive and practical guide discusses the theory and the practicalities of drug safety (also known as pharmacovigilance), and provides essential information on drug safety and regulations in the United States, Europe Union, and more, including: recognizing, monitoring, reporting, and cataloging serious adverse drug reactions.Cobert's Manual of Drug Safety and Pharmacovigilance, Third Edition, teaches the daily practice of drug safety in industry, hospitals, the FDA and other health agencies — both in the United States and around the world — and provides critical information about what to do when confronted with a drug safety problem.Related Link(s)

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Book SynopsisThis highly illustrated volume will describe, through clear diagrams and concise text, how the most prescribed, as well as new medicines, work in the body for a broad range of diseases. By bringing this knowledge together in one place, we will seek to answer the question, 'What is the impact of the accelerating knowledge in biology, drug research and medical sciences on the development and approval of medicines for the treatment of a wide range of diseases'. Furthermore, information on how a successful drug works can make the case for a particular therapy and provide an informed dialog between a patient and physician, or a professor and a student, or a regulator and pharmaceutical scientist.With the continuing explosion of medical information, the book addresses the following themes:This book breaks important new ground by focusing on the cellular biochemistry of selected diseases and how the respective drug works, using a concise, focused and non-technical graphic review.

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Book SynopsisThis volume describes methods and protocols for the fragment-based screening of proteins using Surface Plasmon Resonance (SPR). The initial chapter of the book discusses the principle of SPR for the identification of biomolecular interactions, while the subsequent chapters introduce methods for labelling proteins with different tags including, histidine and biotin tags. It also discusses techniques and factors that affect the amine and biotin-streptavidin coupling and methods to optimize the interactions. Next, it describes fragment preparation for screening in SPR and presents methods to calculate equilibrium dissociation constant (KD) and ligand efficiency (LE). It reviews techniques of next-generation injections that improve the efficiency of the characterization process over traditional SPR by determining the kinetics and affinity in a single step. Finally, the book elucidates a comprehensive yet representative description of challenges associated with the molecular interaction of proteins using SPR.Table of ContentsChapter 1_Introduction to SPR.- Chapter 2_ Principle of SPR (OneStep).- Chapter 3_Identification of Fragment library.- Chapter 4_Preparation of protein with Histidine Tag.- Chapter 5_Preparation of protein with Biotin Tag.- Chapter 6_Protein stability using Thermal Shift Assay (TSA) - pH.- Chapter 7_Protein stability using Thermal Shift Assay (TSA) – DMSO.- Chapter 8_Preparation of Sensor.- Chapter 9_ Optimization and validation of Amine coupling.- Chapter 10_ Optimization and validation of Biotin-strepavidin coupling.- Chapter 11_ Preparation of Fragment for Screening in SPR.- Chapter 12_ Screening of Fragment in SPR.- Chapter 13_ Analysis of Data.- Chapter 14_ Identification and arraying of HITS.- Chapter 15_ Confirmation of Hits – Kinetics (kon, koff, KD, LE).

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Book SynopsisThis book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.Table of Contents1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa.- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds.- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects.- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant.- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana.- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions.- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities.- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production.- 9 Saffron: A prized herb with therapeutic potential against diabetes.- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors.- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future.- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants.- 13 Production of anti-diabetic lignans in flax cell cultures.- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect.- 15 Cryopreservation of Anti-diabetic plants.

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Book SynopsisThis book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.Table of Contents1. Preface2. Introduction2.1. Nanotechnology and its influence2.2. Novel drug delivery systems2.3. Significance of nanomaterials in respiratory diseases3. Nanoparticles in chronic respiratory diseases3.1. Inflammatory respiratory diseases (Asthma, Chronic obstructive pulmonary disease, Tuberculosis, Lung cancer, Cystic fibrosis)3.2. Formulation and role of microparticles, microspheres, microemulsions in respiratory diseases3.3. Formulation and role of polymeric and inorganic nanoparticles3.4. Liposomes, niosomes, and dendrimers targeting in respiratory diseases3.5. Micelle targeting in respiratory diseases4. Targeting immune-system/ cellular level (macrophages & neutrophils) in respiratory diseases using advanced drug delivery systems5. Mucoadhesive drug delivery system in respiratory diseases6. Advancement in translational respiratory research using nanotechnology7. Nanotechnology in pulmonary disease diagnosis8. Clinical trials using in vitro and in vivo models9. Targeting biofilms in respiratory diseases using novel drug delivery systems10. Future prospects and challenges11. Bibliography12. Glossary

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Book SynopsisThis book provides the latest information of life science databases that center in the life science research and drive the development of the field. It introduces the fundamental principles, rationales and methodologies of creating and updating life science databases. The book brings together expertise and renowned researchers in the field of life science databases and brings their experience and tools at the fingertips of the researcher. The book takes bottom-up approach to explain the structure, content and the usability of life science database. Detailed explanation of the content, structure, query and data retrieval are discussed to provide practical use of life science database and to enable the reader to use database and provided tools in practice. The readers will learn the necessary knowledge about the untapped opportunities available in life science databases and how it could be used so as to advance basic research and applied research findings and transforming them to the benefit of human life.Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.Table of ContentsChapter 1: GENCODE Annotation for the Human and Mouse Genome: A User Perspective.- Chapter 2: Genecard a database for gene annotation.- Chapter 3: IHEC: International human epigenome portal.- Chapter 4: Atlas of miRNAs and their Promoters in Human and Mouse.- Chapter 5: RefEX- Reference Expression Dataset.- Chapter 6: The mouse Gene Expression Database.- Chapter 7: ChIP-Atlas.- Chapter 8: Protein structural changes based on structural comparison.- Chapter 9: Single Cell Databases: an Emerging and Essential Tool.- Chapter 10: scIVA: Single Cell Interactive Visualisation and Analysis Data Mining Platform.- Chapter 11: Access and visualise high quality gene expression data with Stemformatics.- Chapter 12: Introduction to Practical Guide to Life Science Databases.

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Book SynopsisThis book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.Table of ContentsSection 1: Diversity, Chemical biology and Ecology of Actinomycetes; and the Discovery of Natural Products Chapter 1: An overview on Natural products from Actinomycetes: their discovery and biosynthesis. Chapter 2: Isolation, identification (cultural and molecular techniques), and systematics of Actinomycetes from various sources (marine, soil, extremophilic environment). Chapter 3: Studies on diversity of nonribosomal peptide synthetase and polyketide synthase gene clusters among taxonomically close Actinomycetes strains. Chapter 4: Chemical elicitors and signaling molecules and their role in elicitation of secondary metabolism in Actinomycetes. Chapter 5: Regulation of antibiotic biosynthesis genes in Actinomycetes at molecular level. Chapter 6: Screening strategies for inhibitors against cancer cells from natural Products repository of Actinomycetes. Chapter 7: Rare and endophytic Actinomycetes in the biosynthesis of bioactive metabolites. Chapter 8: Advances in bioactivity guided isolation of natural products from Actinomycetes. Chapter 9: Natural product discovery from non-Streptomyces Actinomycetes. Chapter 10: Use of high-efficiency CRISPR/Cas9-mediated genome editing to study biology of Actinomycetes. Section 2: Genomic approaches and synthetic biology tools in Actinomycetes drug discovery and industrial compounds Chapter 11: An overview of biomedical, biotechnological and industrial applications of Actinomycetes Chapter 12: Genomics and proteomics approach in natural product discovery in Actinomycetes. Chapter 13: Structural dereplication and strain dereplication strategies and metabolomics in natural product research. Chapter 14: Genome mining of rare Actinomycetes and cryptic pathways for secondary metabolites. Chapter 15: Glycosylated bioactive compound discovery by from Actinomycetes by combination of genome mining, gene inactivation and activation of silent biosynthetic clusters. Chapter 16: Genetic engineering for overproducing bioactive secondary metabolites in Actinomycetes Chapter 17: Transcriptional gene cluster refactoring for increased secondary metabolites production Chapter 18: Synthetic biology in Actinomycetes for natural product discovery Chapter 19: Metabolic engineering of antibiotic factories: new tools for antibiotic production in Actinomycetes Chapter 20: Bioinformatic tools for use in pks and nrps discovery in Actinomycetes.

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Book SynopsisThis volume focuses on the potential use of probiotics in treating metabolic disorders such as diabetes mellitus, metabolic acidosis, and gut dysbiosis. Chapters draw an association between gut microbiota and its diversity with metabolic diseases like diabetes, obesity, related liver and gut disorders; gut-brain axis; increased inflammation, and a compromised immune system resulting from these manifestations and scope of intervention with probiotics. Special attention is laid on describing the mechanisms of action of such beneficial effects of probiotic administration. The ability of probiotics to decrease metabolic endotoxemia by restoring the disrupted intestinal mucosal barrier is also included.The volume is a comprehensive compilation describing the scope and application of probiotic and prebiotic therapy in treating metabolic disorders. Readers will discover how probiotics are not just confined to the microbiology industry but are showing promising results in the medical and pharmaceutical sectors.Table of Contents

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Book SynopsisThe book contains review articles providing a comprehensive overview of cannabis/marijuana’s diverse healing aspects in human healthcare (medicinal, nutraceutical, skincare, etc.). The research articles include the role of cannabis in cancer treatment, drug discovery, cosmeceutical potential, prophylactic and therapeutic use for treating neuropathic pain and migraine, pharmacokinetics, safety profile, and issues related to the consumption of cannabis/marijuana. Another salient feature of the book is a complete mapping and region- and sector-wise critical analysis of cannabis/marijuana patents on healthcare and future directions for the benefit of researchers and businesses/entrepreneurs interested in the rapidly advancing area of cannabis. The text describes cannabis/marijuana’s detailed legal aspects, production prospects, and applications for healthcare and recreational purposes in the USA. It traces the traditional roots of cannabis use in Turkey, Israel, the Middle East, Africa, and India. This unique compendium of articles will be useful as a reference book for students, researchers, academics, business houses, and all individuals interested in medicinal, nutraceutical, cosmeceutical, traditional, legal, and commercial aspects of cannabis usage.Table of ContentsChapter 1. A Complete Patent Analysis of Cannabis/Marijuana in Drug Delivery and Disease Conditions.- Chapter 2. Neuropharmacological Approaches to Modulate Cannabinoid Neurotransmission.- Chapter 3. Cannabinoids in Cancer: Cross-talk Between Cannabinoids and miRNAs.- Chapter 4. Cannabis As A Potent Therapeutic Agent For Pharmaceutical Drugs: Recent Advancement In Drug Discovery And Human Healthcare.- Chapter 5. Cannabinoid-Based Innovative Prophylactic and Therapeutic Interventions for Neuropathic Pain and Migraine.- Chapter 6. The Legality of Use and Consumption of Cannabis (Marijuana) in the United States of America.- Chapter 7. Cannabis in Healthcare: Ethnobotanical and Pharmaceutical Perspectives and Legal Status in Turkey and The Middle East.- Chapter 8. Understanding the Pharmacokinetics, Safety Profile, and Scope of the Concerned Issue to Evade the Consumption of Cannabis/Marijuana.- Chapter 9. Traditional Uses of Cannabis in The Middle East and The Pathway to Cannabis-Based Healthcare in Israel.- Chapter 10. Traditional and Modern Health Uses of Cannabis sativa L. in Africa and its Phytochemical and Pharmacological Profile.- Chapter 11. Traditional Claims on Cannabis: An Indian and Global Scenario.- Chapter 12. Cannabis (Bhanga) in Classical Text of Ayurveda: An Evidence-Based Rationale.- Chapter 13. Cannabis-Based Cosmetic Products and Their Uses.- Chapter 14. Cannabis as A Unique and Valuable Nutraceutical Formulation for the Current and Future Global Wellbeing.- Chapter 15. Traditional, Cultural, and Nutraceutical Aspects of Cannabis in India.

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Book SynopsisThe book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.Table of Contentsa. Advances in Microbial Fermentation and Fermented Food product for Health b. Application of Computational Intelligence Techniques for in Prebiotics, Probiotics, and Nutraceuticals. c. Advances in Genetic Engineering technologies leading to the development of Prebiotics, Probiotics, and Nutraceuticals. d.The Commercial Perspective of Prebiotics, Probiotics, and Nutraceuticals components. e. Innovative technologies linked with the Prebiotics, Probiotics and associated elements. f. Benefits of Probiotics components and effects in immunological purposes. g. Emerging prospects and challenges of Probiotics and Prebiotics to human health. h. Wild edible plants the rich source of Nutraceuticals i. Probiotics Microbes and Biomedical Applications j. Marine Probiotics and Prebiotics for therapeutic application k. Recent Trends in Natural Medicines and Nutraceuticals Research l. Prospective of Probiotic, Prebiotic and Synbiotic for sustainable development of aquaculture

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Book Synopsis​This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.Table of ContentsChapter 1_Repurposing of drugs: Introduction to technologies and application. - Chapter 2_The value added medicine: Pharmacovigilance re-evaluated. - Chapter 3_Polypharmacology and drug repurposing. -Chapter 4_Comparative transcriptome analysis for infectious diseases towards the identification of cellular pathways for drug repositioning. -Chapter 5_Repurposing of drugs for the treatment of microbial diseases. -Chapter 6_RNA-dependent RNA polymerase (RdRp) - a potential therapeutic approach for Coronavirus drug repositioning. -Chapter 7_Drug repurposing for emerging and re-emerging infectious diseases. -Chapter 8_Drug repurposing for the control of COVID-19.-Chapter 9_Repurposing of anti-inflammatory agents in the potential treatment of SARS 2CoV -2 infection. -Chapter 10_Repurposing of immune-modulators for the treatment of cancer with a QSAR approach. -Chapter 11_ Repurposing Cancer drugs towards antiviral targets in developing countries. -Chapter 12_Repurposed drugs for hematological malignancies. -Chapter 13_Reverse translational approach in repurposing of drugs for anticancer therapy. -Chapter 14_Repurposing of Minocycline: a tetracycline antibiotic for neurodegenerative disorders. -Chapter 15_Drug repurposing for Neglected diseases: Approaches, challenges and promising candidates. ​

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Book SynopsisThis book provides a comprehensive overview of medicinal plants and their interaction with abiotic stress in terms of morphological, physiological, biochemical, and molecular variations, and explains the adaptation and tolerance mechanisms involved. It presents various mechanisms that become operative in medicinal plants to combat stressful situations. The book discusses the secondary metabolites and/or bioactive compounds produced in medicinal plants under abiotic stress conditions, and the use of biostimulants and/or phytoprotectants to alleviate the adverse effects of abiotic stresses on medicinal plants. Additionally, it is likely to address opportunities and challenges in molecular and omics studies of medicinal plants under abiotic stress conditions. Overall, the chapters are developed by eminent subject experts with due care and clarity and cover an up-to-date literature review with relevant illustrations. The book would cater to the need of graduate and post-graduate students, researchers as well as scientists, and may attract the attention of pharmaceutical companies/industrialists and health policymakers.Table of ContentsChapter 1. Medicinal plants and abiotic stress: An overview.- Chapter 2. Medicinal plants proteomics in response to abiotic stresses.- Chapter 3. Medicinal plants metabolomics in response to abiotic stresses.- Chapter 4. Secondary metabolite production in medicinal plants under abiotic stress.- Chapter 5. Effect of temperature (cold and hot) stress on medicinal plants.- Chapter 6. Effect of water stress (drought and waterlogging) on medicinal plants.- Chapter 7. Effects of gaseous pollutants on medicinal plants.- Chapter 8. Impact of salinity stress on medicinal plants.- Chapter 9. Impact of aridity on specialized metabolism: Concentration of natural products in plants.- Chapter 10.The role of PGPRs in medicinal plants under abiotic stress.- Chapter 11. Effect of mineral nutrition and PGRs on biosynthesis and distribution of secondary plant metabolites under abiotic stress.- Chapter 12. Impact of phytoprotectants on growth and yield of medicinal plants under abiotic stress.- Chapter 13. Biostimulants and phytohormones improve productivity and quality of medicinal plants under abiotic stress.- Chapter 14. Light (high light/UV radiation) modulates adaptation mechanisms and secondary metabolite production in medicinal plants.- Chapter 15. Recent Strategies to engineer alkaloid biosynthesis in medicinal plants.- Chapter 16. Genome-editing strategies for enhanced stress tolerance in medicinal plants.- Chapter 16. Phytoremediation potential of medicinal plants.- Chapter 17. Phytoremediation potential of medicinal plants.

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Book SynopsisThis book presents the major therapeutic applications of modified rice bran arabinoxylan compound (RBAC) in cancer as well as other chronic inflammatory diseases. Written by active researchers and clinicians in the field of RBAC, the chapters cover the basic science that defines the unique function of RBAC as well as the clinical evidence derived through human studies. Particular focus is on recent findings from research over the past decades. This book is both practical and evidence based. It will be a core resource for researchers, students, and practitioners of nutrition and natural medicine, as well as be of value to all healthcare professionals with interest in integrative medicine. Table of ContentsAttached

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Book SynopsisThis book presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology. The book offers a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, and the pharmaceutical sciences. The main purpose of the present book is to draw on the rich culture, folklore, and biodiversity of immunity-boosting medicinal plants of the Western Himalayas, with particular emphasis on the Indian Trans-Himalayan and Western Himalayan region. All the plants included in the present book are extensively used by the local tribes and people for their health-promoting properties from ancient times. This book will be a substantial contribution to the knowledge of the region and the country. Also, the book will be very useful to scientists, graduates, and undergraduates, along with researchers in the fields of natural products, herbal medicines, ethnobotany, pharmacology, chemistry, and biology. Further, it is an equally significant resource for a person working in different traditional medicinal systems; doctors (especially those engaged in Ayurveda, Chinese traditional medicinal system, Amchi, and allopathy); the pharmaceutical industry (for drug design and synthesis); biochemistry and biotechnology sciences; and the agricultural sciences. Table of Contents1. Introduction to Western Himalayas.- 2. Achillea millefolium L., Common Yarrow.- 3. Arisaema jacquemontii Blume, Jacquemont's Cobra Lily.- 4. Species of Arnebia genus found in the western Himalayas.- 5. Species of the Berberis genus found in the western Himalayas.- 6. Dactylorhiza hatagirea (D.Don) Soo – Himalayan Marsh Orchid.- 7. Fritillaria roylei Hook.f.: Himalayan Fritillary.- 8. Gentiana kurroo Royle: Himalayan Gentian.- 9. Habenaria intermedia D.Don and Habenaria edgeworthii Hook., f. ex Collett.: The Western Himalayan medicinal Plants.- 10. Humulus lupulus L.: Beer plant.- 11. Inula racemosa Hook. f. – Puskarmool: Its ethnobotanical uses, phytochemicals and pharmacological activities.- 12. Juniperus recurva Buch.-Ham. ex D.Don and Juniperus squamata D. Don: Himalayan Juniper.- 13. Lancea tibetica Hook.f. & Thomson: Ethnobotany, phytochemistry and pharmacology.- 14. Malaxis muscifera (Lindley) O. Kuntze. and Malaxis acuminata D. Don.: Jeevak.- 15. Picrorhiza kurroa Royle ex Benth.: Kutki.- 16. Species of the genus Polygonatum found in the Western Himalayas.- 17. Species of the genus Rhodiola found in the Western Himalayas.- 18. Saussurea lappa C.B. Clarke: Kushta/Kut.- 19. Saussurea lappa C.B. Clarke: Kushta/Kut.- 20. Species of the genus Selinum found in the western Himalayas.- 21. Swertia chirayita (Roxb. ex Flem.): Chirayata/Chiretta.- 22. Taxus wallichiana Zucc.: The Himalayan yew.- 23. Tribulus terrestris L.: Gokshur /Gokharu.- 24. Species the Genus Viola found in Western Himalayas.

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Book SynopsisNobel laureate Tu Youyou won the 2015 prize for Medicine/Physiology for the discovery of artemisinin, a drug therapy for malaria that has saved millions across the globe.This book traces the path of discovery beginning with Chairman Mao's 1964 instruction to Chinese researchers to find a cure for malaria, a disease that plagued the military and civilians alike in endemic regions. It chronicles the years of painstaking research to find effective anti-malarial drugs, and how an entry in a collection of traditional Chinese medicine prescriptions gave Tu Youyou the clue which led her to successfully extract artemisinin from the plant, Artemisia annua.Gathering together information from a variety of sources including first-hand accounts, this book describes the contributions of the many organisations, scientists, doctors and countless others who played a part in the process of discovery and clinical testing. It also provides insights into the challenges of carrying out such an extensive research project with limited resources during the upheavals of the Cultural Revolution. An inspirational read for young scientists.Includes the translation of Professor Tu Youyou's 2015 Nobel Lecture.

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Book SynopsisThis book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. Table of Contents

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Book SynopsisThis book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.Trade ReviewThe development of the Handbook of Personalized Medicine is timely. Medicine and health have evidently moved on and continue to progress and develop at a pace. Gone are the days, perhaps, when medical treatments for patients were developed and designed as a ‘one size fits all’ solution. Much more is now understood about individual differences in the way in which diseases develop and specifically also about individual differences in response to treatments. ... This book represents an exceedingly comprehensive and detailed account of these developments, with the aim of integrating certain of these approaches into every day clinical practice. ... its structure is clearly laid out, contributing authors clearly stated and the periodic use of comprehensive tables, graphs, and colour figures undoubtedly improve its understanding. ... This book has been a massive undertaking to produce and portrays a journey from the most basic considerations through to the medical practice of the future."—David Fishwick, Occupational Medicine JournalTable of ContentsImplementation of Pharmacogenetics in Evidence-Based Medicine. Pharmacotyping-Based Drug Prescription. Pharmacogenetics-Guided Antithrombotic Therapy. Translational Bioinformatics and Systems Biology. Predictive Genomic Signatures. Personalizing Stem Cell Therapeutic Potential. RNAi Nanomedicines. Nanotechnology Advancements for Personalized Medicine. Pharmacogenetics and Pharmacovigilance. Genetic Variability of Cytochrome P450 Drug Metabolizing Enzymes. Developmental Pharmacology and Pediatric Drug Dosing. Functional Mapping of drug response; Predictive molecular signatures; Information-based medicine; Simcyp population-based ADME Simulator. The Coriell Personalized Medicine Collaborative. Drug Bioavailability and Gene Profiling. Safety Assessment in Nanotechnology. In Vivo Pharmacology. Biostatistics and Text Mining. Intersection of Pharmacology, Imaging, and Genetics. Boron Neutron Capture Therapy. Personalized Medicine in Breast Cancer. Personalized Therapy of Metabolic Diseases. Molecular Biomarkers and Imaging. Pharmacogenomics of Drug-Induced Hepatotoxicity. Education Programs for Pharmacogenomics. Computerized Clinical Decision Support Systems for Prescribing; Therapeutic Drug Monitoring. Cost-Effectiveness of Pharmacogenomics; Ethical and Legal Pharmacogenomics Issues.

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Book SynopsisThis book focuses on applications of compound library design and virtual screening to expand the bioactive chemical space, to target hopping of chemotypes to identify synergies within related drug discovery projects or to repurpose known drugs, to propose mechanism of action of compounds, or to identify off-target effects by cross-reactivity analysis. Both ligand-based and structure-based in silico approaches, as reviewed in this book, play important roles for all these applications. Computational chemogenomics is expected to increase the quality and productivity of drug discovery and lead to the discovery of new medicines.Table of ContentsForeword. Chemogenomics Approaches for the Quantitative Comparison of Biological Targets. Considerations on the Drug-like Chemical Space. Chemogenomic Protein-Family Methods in Drug Discovery: Profile-QSAR and Kinase-Kernel. Virtual Screening and Target Fishing for Natural Products Using 3D Pharmacophores. Computational Analysis of Ligand Binding Pockets. Binding Site Similarity Search to Identify Novel Target-Ligand Complexes. ChemProt: A Disease Chemical Biology Database. Scientific Requirements for the Next Generation Semantic Web-based Chemogenomics and Systems Chemical Biology Molecular Information System OPS. Index.

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Book SynopsisHydrogels are an emerging area of interest in medicine as well as pharmaceutics, and their physico-chemical characterization is fundamental to their practical applications. Compared with synthetic polymers, polysaccharides that are widely present in living organisms and come from renewable sources are extremely advantageous for hydrogel formation. Furthermore, polysaccharides are usually non-toxic and biocompatible and show a number of peculiar physico-chemical properties that make them suitable for a wide variety of biomedical applications. This book bridges the gap between the preparation of hydrogels and their characterization techniques. It aims to offer a valid support that can help the readers find appropriate keys to open the doors to the complex world of polysaccharide hydrogels.Trade Review"This book unveils the secrets of polysaccharide hydrogels that make them invaluable tools in the biomedical field. It presents elegant approaches to preparing hydrogels, techniques for a very detailed characterization of polysaccharides and their hydrogels, and recent applications."— Prof. Carmen Alvarez-Lorenzo, University of Santiago de Compostela, Spain"This book is one of the first to cover all the aspects of polysaccharide hydrogels from the basic aspects of chemistry and characterization to their biological relevance and medical applications and is a great and comprehensive answer to the first questions concerning hydrogels."— Prof. Pierre Weiss, University of Nantes, France"‘The gel is easier to recognize than to define (Dorothy Jordan Lloyd, 1926). This book gives significant answers to this ‘old’ but still intriguing statement as it brings together most of the up-to-date information on the hot topic of hydrogels obtained from polysaccharides, and their preparation, characterization and application in the field of pharmaceutics."— Prof. Gaetano Giammona, University of Palermo and The Biophysics Institute, ItalyTable of ContentsIntroduction. Hydrogels. Rheological Characterization of Hydrogels. Hydrogel Mesh Size Evaluation. Dynamic Light Scattering. NMR Methodologies in the Study of Polysaccharides. Small-Angle Neutron Scattering of Polysaccharide Hydrogels. The Method of Small-Angle X-ray Scattering and Its Application to the Structural Analysis of Oligo- and Polysaccharides in Solution. Stimuli Responsive Polysaccharide-Based Hydrogels. Properties and Biomedical Applications of Gellan Gum Hydrogels. Polysaccharide Hydrogels with Magnetic Nanoparticles. Physical and Chemical Hyaluronic Acid hydrogels and Their Biomedical Applications. Alginate Hydrogels: Properties and Applications. Polysaccharide Hydrogels: The Present and the Future.

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Book SynopsisChapter 1. Tropane Alkaloids: A Biologically Important Group of Nitrogen Containing Heterocyclic Phyto-Secondary Metabolites.- Chapter 2. Plant Sources of Tropane Alkaloids.- Chapter 3. Chemistry of Tropane Alkaloids: A Comprehensive Study of Biologically Important Group of Nitrogen Containing Heterocyclic Phyto-Secondary Metabolites.- Chapter 4. Biosynthesis of Tropane Alkaloids.- Chapter 5. Pharmacology of Tropane alkaloids.- Chapter 6. Tropane alkaloids in food commodities - occurrence in food and feed.- Chapter 7. Edible plant sources containing low and non-toxic levels of tropane and nortropane alkaloids.- Chapter 8. Tropane Alkaloids: Biosimilar and Biopharmaceutics.- Chapter 9. Tropane Alkaloids in vitro production, Current status, and Perspectives.- Chpter 10. Production of Important Pharmaceutical Compound, Tropane Alkaloids through Metabolic Engineering.- Chapter 11. Cultivation of Tropane Alkaloid yielding plants.- Chapter 12. Micropropagation of Tropane Alkaloid Yielding plants.- Chapter 13. Cocaine – a stimulant tropane alkaloid drug and its regulation.

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Book SynopsisChapter 1_ Introduction to Exosome and its role in Brain disorders.- Chapter 2_ Exosomes: Biogenesis, Composition and Synthesis.- Chapter 3_ Therapeutic Impact of Exosomes in Stroke and Transient Ischemic Attack (TIA).- Chapter 4_ Role of exosomes in Multiple Sclerosis.- Chapter 5_ Therapeutic impact of exosomes Stroke and Transient Ischemic Attack (TIA).- Chapter 6_ Role of exosomes in Parkinson's and Alzheimer's diseases.- Chapter 7_ Role of exosomes in Epilepsy and other Seizure Disorders.- Chapter 8_ Role of exosomes in management of depression.- Chapter 9_ Role of Microbiota-Derived Exosomes in Gut-Brain Communication for the treatment of brain disorders.- Chapter 10_ Advancement of Engineered Exosomes to deliver therapeutic protein cargos in brain disorders.- Chapter 11_ Correlation between exosomes and neuro inflammation in various brain disorders.- Chapter 12_ Recent challenges of exosomes as novel carrier in various brain disorders.- Chapter 13_Advancement of radiolabeled exosomes in brain disorders.- Chapter 14_ Exosomes as future diagnostic tool for brain disorders.- Chapter 15_ Toxicity studies of exosomes and the potential overcome approaches.

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Book SynopsisExplores the benefits, risks, and growing acceptance of modern psychedelic therapy

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