Oncology Books

Book SynopsisThis eighteenth volume of the Evidence-based Clinical Chinese Medicine series aims to provide a multi-faceted 'whole evidence' analysis of the management of pain due to a range of cancers (cancer pain) using integrative Chinese medicine.Beginning with an overview of how cancer pain is conceptualised and managed in conventional medicine, the authors then summarise the differential diagnosis and managment of cancer pain in contemporary Chinese medicine based on clinical guidelines and contemporary books. The third chapter provides detailed analyses of how cancer pain and related disorders were treated with herbal medicine and acupuncture in past eras based on the classical Chinese medical literature.The subsequent chapters comprehensively review the current state of the clinical trial evidence for the integrative application of Chinese herbal medicines (Chapter 5), acupuncture (Chapter 7), other Chinese medicine therapies (Chapter 8) and combination Chinese medicine therapies (Chapter 9) in the management of cancer pain, as well as analyse and evaluate the results of these studies from an evidence-based medicine perspective. Chapter 6 reviews and summarises experimental evidence for the bioactivity of commonly used Chinese herbs and their constituent compounds. The outcomes of these analyses are summarised and discussed in Chapter 10 which alsoidentifies implications for the clinical practice of Chinese medicine and for future research.This book can inform clinicians and students in the fields of integrative medicine and Chinese medicine regarding contemporary practice and the current evidence base for a range of Chinese medicine therapies used in the management of cancer pain, including herbal formulas and acupuncture treatments, in order to assist clinicians in making evidence-based decisions in patient care. It also provides researchers with a comprehensive summary of the state of the field than can inform future.The following features mark the importance of this book in the field:Table of ContentsEvidence-Based Chinese Medicine; Classical Chinese Medicine Literature for Cancer Pain and Associated Disorders; Contemporary Clinical Management of Cancer Pain with Integrative Chinese Medicine; Assessment of the Clinical Trial Evidence for Chinese Herbal Medicine, Acupuncture Therapies, Remedial Massage, and Combinations of Chinese Medicine Therapies in Integrative Cancer Pain Management;

Read more less

Book SynopsisThe 24th volume of this highly successful series includes new contemporary topics such as corrosive injuries of the oesophagus, post-gastrectomy complications, advances in imaging of inflammatory bowel disease, unusual presentations of gallstones, gall bladder cancer with jaundice, minimally invasive pancreatic surgery, and enhanced recovery after surgery. Finally, the chapter on advances in GI surgery, like in each past volume, reviews important new developments in the field. The GI Surgery Annual 24th Volume provides an overall roundup of selected topics that were deemed particularly relevant and topical by the series editors.Table of ContentsCorrosive injuries of the oesophagus.- Post-gastrectomy complications.- Advances in imaging of inflammatory bowel disease.- Unusual presentations of gallstones.- Gall bladder cancer with jaundice: The unscaled frontier.- Minimally invasive pancreatic surgery: What the future holds for this field?.- Enhanced Recovery after Surgery: Applicability and results for abdominal surgery and impediments for universal usage.- Advances in gastrointestinal surgery.

Read more less

Book SynopsisThis book provides a comprehensive and up-to-date overview of major technical advances and research findings in the field of brachytherapy. Especially research conducted on brachytherapy in Japan has made tremendous strides, offering readers valuable insights into new treatment outcomes, evidence and techniques. In the respective chapters, each author elucidates cutting-edge findings, addressing both the basic and clinical aspects including the application to various cancers, and especially focusing on highly valuable data gleaned in Japan. As such, the book will benefit not only radiation oncologists but also basic researchers, radiation technologists, medical physicists and members of medical staff who are involved in the development and utilization of this advanced therapy.Trade Review“It is an informative, easy to follow and very well-written text. … It would be a very interesting read for radiation oncologists and radiotherapy physicists interested in brachytherapy.” (Wojciech Polak, RAD Magazine, September, 2019)Table of ContentsPart I. General.-1. History of Japanese brachytherapy.-2. Japanese brachytherapy in the world.-3. Deformable image registration in brachytherapy: Beyond dose volume histogram.-Part II. Gynecology.-4. Moving on from LDR to HDR.-5. Intracavitary brachytherapy from 2D to 3D.-6. Midline block (Central shield) .-7. Hybrid brachytherapy.-8. Interstitial brachytherapy: radical and salvage.-9. Asian cooperation and global trend.- Part III. Prostate.-10. Prostate brachytherapy: the fact and the way to go.-11. How we led Japanese low-dose-rate brachytherapy to successful practice (Urologist perspecitive).-12. How we led Japanese low-dose-rate brachytherapy to successful practice (Radiation oncologist perspecitive).-13. HDR monotherapy.- 14. Single-fraction boost HDR.- Part IV. Breast.-15. Japanese experience and American trend.-16. Hungarian experience and European trend.- Part V. Head and Neck.-17. Low-dose-rate brachytherapy for oral cancer.-18. High-dose-rate brachytherapy for oral cancer.-19. Eye plaque brachytherapy for retinoblastoma and melanoma.-Part VI. Intraluminal.-20. Intraluminal brachytherapy for endobronchial cancer.-21. Intraluminal brachytherapy for esophageal cancer.-22. Intraluminal brachytherapy for biliary tract cancer.

Read more less

Book SynopsisThis book explores all aspects of preventive oncology of the female genital tract and provides readers with detailed insights on the topic. Preventive oncology has long been recognized as a pressing need, though formally few steps have been taken to actively promote it.The book’s respective chapters holistically cover the concept of cancer prevention for the female genital tract & breast. In addition, it explains the evidence-based value of each screening modality, and the rationale behind the recommended screening guidelines. In closing, the book highlights a wealth of recent evidence-based literature, making it a highly informative resource that will significantly broaden readers’ understanding of preventive oncology.Table of ContentsHPV epidemiology in prevention of cervical cancer.- Cytology versus HPV testing for primary prevention.- Methods of HPV testing: clinical implications.- Novel biomarkers for HPV detection.- Colposcopic principles & tissue basis.- Colposcopic features of cervical intraepithelial lesions.- HPV vaccines.- Cervical cancer screening in pregnancy.- Cervical cancer screening in low resource settings.- Ablative methods for treatment of intraepithelial lesions.- CIN 2 lesions: management dilemmas.- Follow up after treatment of CIN.- Epidemiology/Risk factors of endometrial cancers.- Role of cytology.- Hysteroscopy and cancer prevention.- Premalignant lesions of endometrium? Endometrial hyperplasia.- Hereditary endometrial cancers & prevention.- Chemoprevention of endometrial cancers.- Ovarian malignancy: risk factors.- Role of tumor markers.- Sonographic screening.- Role of prophylactic surgery/oophorectomy.- Risk factors for breast malignancy.- Role of breast examination/CBE.- Facts about mammography.- Cancer risk & genetic testing.- What’s new in breast screening.- Classification of vulval lesions.- Vulvoscopy: the way forward.- Vulval intraepithelial lesions(VIN): diagnosis & management.- Vaginal intraepithelial lesions(VAIN).- Screening guidelines for cervical cancer.- Screening guidelines for endometrial cancer.- Recommendations for ovarian cancer screening.- Breast cancer screening strategies.- Case discussions on various scenarios of different premalignant conditions of cervix, endometrium, breast & ovary.

Read more less

Book SynopsisThis book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.Table of ContentsChapter 1. Cancer of the Skin:Type and Etiology.- Chapter 2. Therapeutic intervention in skin cancer: Future prospects.- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer.- Chapter 4. The Epidemiology of Skin Cancer Worldwide.- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer.- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer.- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy.- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era.- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy.- Chapter 10. Biomedical engineering in cancer diagnosis and therapy.- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology.- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy.- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-

Read more less

Book SynopsisThis atlas describes and illustrates in detail the surgical procedures employed in laparoscopic anatomical liver resection, according to tumor location. The surgical approach and techniques are explained for each type of laparoscopic liver resection based on the involved anatomical segment, section, and hemi-liver. Attention is also drawn to potential complications and the means of preventing and managing them. Beyond anatomical liver resection, guidance is provided on non-anatomical resections that do not pay regard to segmental, sectional, or lobar anatomy. The coverage is completed by the inclusion of useful information on instruments and energy devices as well as the basic skills required for laparoscopic liver resection. In presenting a clear practical approach to each laparoscopic anatomical major and minor resection, the Color Atlas of Laparoscopic Liver Resection will be an invaluable guide for trainees. In addition, it will equip more experienced surgeons with much useful information that will enable them to further improve their technique.Table of Contents1. Introduction.- 2. Instruments and energy devices for laparoscopic liver resection.- 3. Basic skills for laparoscopic liver resection.- 4. Anatomical liver resection.- 5. Non-anatomical liver resection.- 6. Others.

Read more less

Book SynopsisThis book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. Table of ContentsChapter 1. Obesity induced chronic low-level inflammation and cancers.- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers.- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation.- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer.- Chapter 6. Immune response and oxidative stress in obesity induced cancer.- Chapter 7. Role of gene polymorphism in obesity and cancer.- Chapter 8. Therapeutic role of green tea in obesity and cancer.- Chapter 9. Effect of dietary phytochemicals in obesity and cancer.- Chapter 10. Resveratrol as anti-obesity and anticancer agent.- Chapter 11. EGCG as anti-obesity and anticancer agent.- Chapter 12. miRNAs as therapeutic target in obesity and cancer.- Chapter 13. In silico updates on lead identification for obesity and cancer.- Chapter 14. In vivo models for obesity and obesity related carcinogenesis.- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases.- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.

Read more less

Book SynopsisThis comprehensive book presents the latest evidence-based data on pancreatobiliary malignancies, including the epidemiology, examination, treatment and endoscopic management. It explores a range of topics, such as risk factors, detection strategies, and novel treatment approaches like precision medicine and immunotherapy.Although there have been rapid improvements in the management of these diseases, the survival period has not yet reached a satisfactory level. This book will help those doctors needing to share the latest information with the patients and their families. It provides a wealth of practical information to help surgeons, endoscopists and oncologists as well as physicians, basic researchers and professionals at medical device and pharmaceutical companies broaden their understanding of the current treatment and management strategies for pancreatobiliary malignancies.Table of ContentsPart I Current topics in Epidemiology and Examinations of Pancreatic Cancer and Cholangiocarcinoma 1 Risk Factors for Pancreatic Cancer and Cholangiocarcinoma 2 Detection strategies and examination of early pancreatic cancer 3 Biomarkers for Pancreatic Cancer and Cholangiocarcinoma 4 Recent advances of precision medicine in pancreatic cancer and and cholangiocarcinoma Part II Anti-cancer Treatments for Pancreatic Cancer 5 Chemotherapy for locally advanced and metastatic pancreatic cancer 6 Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer 7 Adjuvant Chemotherapy for Pancreatic Cancer 8 Conversion Surgery in Pancreatic Cancer 9 Radiotherapy for pancreatic cancer Part III Anti-cancer Treatments for Cholangiocarcinoma 10 Chemotherapy for Unresectable Cholangiocarcinoma 11 Adjuvant chemotherapy for cholangiocarcinoma 12 Neoadjuvant therapy and conversion surgery for cholangiocarcinoma 13 Radiotherapy for Cholangiocarcinoma Part IV New Treatment for Pancreatic Cancer and Cholangiocarcinoma 14 Precision medicine for pancreatic cancer and cholangiocarcinoma 15 Immunotherapy for pancreatic cancer and biliary tract cancer 16 Treatment approach for pancreatic ductal adenocarcinoma with peritoneal dissemination 17 Treatment strategies for frail and elderly patients with pancreatic cancer Part V Endoscopic Management of Pancreatic Cancer and Cholangiocarcinoma 18 Endoscopic diagnosis of pancreatic cancer and cholangiocarcinoma 19 Preoperative biliary drainage for pancreatic cancer and cholangiocarcinoma 20 ERCP for malignant biliary obstruction for unresectable pancreatic cancer and cholangiocarcinoma 21 Interventional EUS for pancreatic cancer and cholangiocarcinoma 22 Novel endoscopic focal therapy for pancreatic cancer and cholangiocarcinoma 23 Endoscopic management of gastrointestinal obstruction from pancreaticobiliary cancer 24 Development of Self-expandable Biliary Metal Stents for Pancreatic Cancer and Cholangiocarcinoma

Read more less

Book SynopsisThis highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease. Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars.Table of Contents1 History, Advancements, and Future Strategies 2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis 3 Genetic Testing 4 Variants of uncertain significances in hereditary breast and ovarian cancer 5 Genetic counseling in Hereditary Breast and Ovarian Cancer 6 Hereditary Breast Cancer 7 Hereditary Ovarian Cancer 8 Risk-Based Breast Cancer Screening 9 Chemoprevention for Breast Cancer 10 Chemoprevention for Ovarian Cancer 11 Risk-Reducing Mastectomy (RRM) 12 Risk-reducing salpingo-oophorectomy (RRSO) 13 Panel Testing 14 Germline Findings through Precision Oncology for Ovarian Cancer 15 Germline Findings from Genetic Testing for Breast Cancer 16 Hereditary Breast and Ovarian Cancer (HBOC) Database 17 Ethical Issues: Overview in Genomic analysis and Clinical Context 18 PARP Inhibitors-Mechanism of action 19 PARPi - Efficacy in Hereditary Breast Cancer 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer

Read more less

Book SynopsisThis book presents multiple facets of cancer biology, including cancer diagnosis, therapeutics to the latest developments in cancer informatics, and applications of artificial intelligence for improving oncologic care. The initial section of the book discusses factors contributing to the development and causes of cancer. The subsequent sections discuss the basic principle of imaging and therapeutic techniques, including MRI, CT, and positron emission tomography (PET) Scan. The book further, explores the implications of cancer chemotherapy on the immune system and emphasizes the effective management of cancer-related pain. Towards the end, it covers recent advancements in cancer treatment, including targeted therapy, immunotherapy, interventional radiotherapy, and stem cell-based therapy. Lastly, it summarizes essential strategic elements of cancer informatics for improving patient outcome.Table of ContentsChapter 1_ introductory cancer biology. –Chapter 2_Cancer: Getting informed about the Basics. –Chapter 3_Tumour Biology: An Introduction. –Chapter 4_Role of Angiogenesis in Tumour–Chapter 5_Biology, Chemistry and Physics of Cancer Cell Motility and Metastasis. –Chapter 6_MRI, CT, and PETSCAN: An Engineer’s Perspective. –Chapter 7_Diffusion, MRI, and Cancer Diagnosis: Physicists’ Outlook. –Chapter 8_Oncology: Radiation Oncologist’s View. –Chapter 9_Radiomics: Comprehensive and Advance Image Analysis based Radiological Investigations. –Chapter 10_Oncology: Biochemists’ Perspective. –Chapter 11_Oncology: Pathologist’s View. –Chapter 12_Surgical Oncology: An Overview. –Chapter 13_Medical Oncology in Cancer Treatment. - Chapter 14_Effects of Cancer Chemotherapy on Immune System. –Chapter 15_Side-effects of Cancer Chemotherapy. –Chapter 16_Telomerase and its Therapeutic Implication in Cancer. –Chapter 17_Pain Management in Oncology. –Chapter 18_Other Approaches in Cancer Research: Stem-cell Research, Translational Research, and Immuno-therapy. –Chapter 19_Cancer Cell Lines: It’s Implication in Therapeutics. –Chapter 20_ Genomics of Cancer. –Chapter 21_Diabetes and Cancer Link. –Chapter 22_Cancer Genomics and Diagnostics: Northeast Indian Scenario. –Chapter 23_Oncology Informatics, AI and Drug Discovery. –Chapter 24_Statistics in Cancer: Diagnosis, Disease Progression, Treatment Efficacy and Patient Survival Studies. –Chapter 25_Epidemiology of Cancer: Asian Perspective.

Read more less

Book SynopsisThis book presents original papers reflecting topics featured at the international symposium entitled “Fusion of Mathematics and Biology” and organized by the editor of the book. The symposium, held in October 2020 at Osaka University in Japan, was the core event for the final year of the research project entitled “Establishing International Research Networks of Mathematical Oncology.” The project had been carried out since April 2015 as part of the Core-to-Core Program of Japan Society for the Promotion of Science (JSPS). In this book, the editor presents collaborative research from prestigious organizations in France, the UK, and the USA. By utilizing their individual strengths and realizing the fusion of life science and mathematical science, the project achieved a combination of mathematical analysis, verification by biomedical experiments, and statistical analysis of chemical databases.Mathematics is sometimes regarded as a universal language. It is a valuable property that everyone can understand beyond the boundaries of culture, religion, and language. This unifying force of mathematics also applies to the various fields of science. Mathematical oncology has two aspects, i.e., data science and mathematical modeling, and definitely helps in the prediction and control of biological phenomena observed in cancer evolution.The topics addressed in this book represent several methods of applying mathematical modeling to scientific problems in the natural sciences. Furthermore, novel reviews are included that may motivate many mathematicians to become interested in biological research.Table of ContentsPART 1: Mathematical Modeling: D. Guan, X. Luo, and H. Gao, Constitutive Modelling of Soft Biological Tissue from Ex Vivo to In Vivo: Myocardium as an Example.- T. Colin, T. Michel, and C. Poignard, Mathematical Modeling of Gastro-intestinal Metastasis Resistance to Tyrosine Kinase Inhibitors.- Y. Tanaka and T. Yasugi, Mathematical Modeling and Experimental Verification of the Proneural Wave.- D. Kumakura and S. Nakaoka, Exploring Similarity between Embedding Dimension of Time-series Data and Flows of an Ecological Population Model.- T. Hayashi, Mathematical Modeling for Angiogenesis.- S. Collin, Corridore and C. Poignard, Floating Potential Boundary Condition in Smooth Domains in an Electroporation Context.- N. L. Othman and T. Suzuki, Free Boundary Problem of Cell Deformation and Invasion.- L. Preziosi and M. Scianna, Multi-level Mathematical Models for Cell Migration in Confined Environments.- S. Magi, Mathematical Modeling of Cancer Signaling Addressing Tumor Heterogeneity.- N. Sfakianakis and Mark A.J. Chaplain, Mathematical Modelling of Cancer Invasion: A Review.- T. Williams, A. Wilson, and N. Sfakianakis, The First Step towards the Mathematical Understanding of the Role of Matrix Metalloproteinase-8 in Cancer Invasion.- PART II: Biological Prediction: T. Ito, T. Suzuki, and Y. Murakami, Mathematical Modeling of the Dimerization of EGFR and ErbB3 in Lung Adenocarcinoma.- H. Kubota, Selective Regulation of the Insulin-Akt Pathway by Simultaneous Processing of Blood Insulin Pattern in the Liver.- D. Oikawa, N. Hatanaka, T. Suzuki, and F. Tokunaga, Mathematical Simulation of Linear Ubiquitination in T Cell Receptor-mediated NF-κB Activation Pathway.- Y. Ito, D. Minerva, S. Tasaki, M. Yoshida, T. Suzuki, and A. Goto, Time Changes in the VEGF-A Concentration Gradient Lead Neovasculature to Engage in Stair-like Growth.- N. Hatanaka, M. Futakuchi, and T. Suzuki, Mathematical Modeling of Tumor Malignancy in Bone Microenvironment.- M. Yamamoto and Jun-ichiro Inoue, Signaling Networks Involved in the Malignant Transformation of Breast Cancer.- PART III: Data Science: R. Morishita, H. Takahashi, and T. Sawasaki, Cell-free Based Protein Array Technology.- Y. Nojima and Y. Takeda, Omics Data Analysis Tools for Biomarker Discovery and the Tutorial.- M. Oyama and H. Kozuka-Hata, Integrative Network Analysis of Cancer Cell Signaling by High-resolution Proteomics.- N. Nakamura and R. Yamada, Distance-matrix-based Extraction of Motility Features from Functionally Heterogeneous Cell Populations.- S. Kawasaki, H. Hayashi, and Y. Tominaga, Data Analytic Study of Genetic Mechanism of Ovarian Carcinoma from Single Cell RNA-seq Data.

Read more less

Book SynopsisThis reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​Table of ContentsSection A: Therapeutic implications of natural compounds Chapter 1 Natural dietary alkaloids and its synthetic derivatives as oxidative stress-inducing agents for cancer therapy Chapter 2. Role of antioxidants in the treatment of hepatocellular carcinoma Chapter 3. Antioxidants in cancer prevention Chapter 4. Therapeutic potential of natural agents against oxidative stress influenced colitis-associated cancer. Chapter 5. Prevention of fertility due to chemotherapy-induced ovarian failure: Role of therapeutic antioxidant Chapter 6 Human papiloma virus (HPV) related cancer, redox state and antioxidant therapy. Chapter 7. The effect of antioxidants on chemotherapy-induced apoptosis Chapter 8. Therapeutic potential of Natural antioxidants in Chemotherapeutic Agent Cyclophosphamide Associated Cardiotoxicity Chapter 9. Therapeutic implications of phytochemicals in ROS induced cancer Chapter 10. Nutraceuticals in cancer therapy: challenges and opportunities Chapter 11. Role of dietary antioxidants in chemoprevention of nitrosamines induced carcinogenesis. Chapter 12 Role of Rosmarinus officinalis (rosemary) essential oil in oxidative stress induced brain cancer Chapter 13 Therapeutic Flavonoids in cancer: ROS-mediated mechanisms Chapter 14 Protective effect of Quercetin, Luteolin, and Fisetin via stimulating the p53 mediated signaling in cancer. Section B: Therapeutic implications of synthetic compounds Chapter 15. Nitrogen- and sulfur-containing heterocycles as dual anti-oxidant and anti-cancer agents Chapter 16. Small molecule inhibitors that target signal transduction pathways involved in oxidative stress-induced cancer: current status and future directions. Chapter 17. Polyphenolic acetates as therapeutics and adjuvant in the therapy of Cancer. Chapter 18 Application of Peptides as cancer therapeutic Chapter 19 Retinoids and reactive oxygen species in cancer cell death and therapeutics. Chapter 20. Benzophenone-2 on oxidative stress induced brain cancer Chapter 21 Salubrinal promotes cisplatin resistance in human gastric cancer cells via enhabced xCT expression and glutathione biosynthesis. Chapter 22. Beyond natural antioxidants in cancer therapy: novel synthetic approaches in harnessing oxidative stress. Chapter 23. Evaluation of chalcore-linked pyrazole pyrimidines in oxidative stress induced breast cancer Chapter 24. Engineered biopolymer for post operated cancer wound healing Chapter 25. Role of TNF-α inhibitors in oxidative stress induced ovarian cancer Chapter 26. Oxidative stress induced colon cancer: effect of Tanshienone Chapter 27. PARP inhibitor olaparib in oxidative stress induced colon cancer Chapter 28. Prevention of ROS induced gastrointestinal carcinoma by synthetic compounds Section C : Radiation and photodynamic approaches in ROS induced cancer therapeutics Chapter 29 Radiotherapy and Oxidative Stress Chapter 30. Photodynamic therapy induced oxidative stress for cancer treatment. Chapter 31 Hybrid nanomaterials for photodynamic therapy Chapter 32. Cross-talk between ROS dependent apoptotic and autophagic signalling pathways in Zn(II) pththalalocyanine photodynamic therapy in melanoma Chapter 33 Elevating the reactive oxygen species in cancer cells by photodynamic therapy: Pro-oxidative approach for cancer treatment. Section D: Non-coding RNA in therapeutics of ROS induced cancer Chapter 34 Oxidative stress mediated miRNA regulation in cancer Chapter 35 Non-coding RNAs in the regulation of voltage gated anion channels: An emerging aspect of ROS induced cancer therapeutics Chapter 36. Exosomal non-coding RNAs: A future of therapeutics in regulating oxidative stress induced breast cancer. Chapter 37 Chapter miRNA and oxidative stress cross talk in cancer Chapter 38 miRNA-mediated oxidative stress induction in cancer Chapter 39. miRNA and oxidative stress cross talk in cancer Chapter 40. A Critical approach in the Analysis of lncRNA characteristics for Cancer Therapy Chapter 41. Long non coding RNA acting as therapeutic target for oxidative stress induced pancreatic cancer Chapter 42. Short non-coding RNAs: Emerging molecular players in therapeutics of ROS induced cancer Section E : Stem cells in therapeutics of ROS induced cancer Chapter 43. Colon cancer stem cells: Target for treatment of oxidative stress induced colorectal cancer Chapter 44. Therapeutic modalities regarding ROS in leukemia and hematopoietic stem/progenitor cell perspective Chapter 45.Stemness and stromal niche: Targets in oxidative stress induced oral cancer Chapter 46. Targeting developmental pathways in Stem Cell for the therapy of Cancer Chapter 47. Cancer stem cell oxidative phosphorylation: Target for cancer therapy. Chapter 48. Targeting oxidative stress specific NRF2 in pancreatic cancer stem cells Chapter 49. Stem cells in ROS induced cancer therapy. Section F: Nanotechonology based therapeutics of ROS induced cancer Chapter 50 Role of natural polyphenols against toxicity induced by oxidative stress in cancer cells.Title: The multifaceted function of nanoparticles in modulating oxidative stress for cancer therapy Chapter 51. Emerging role of redox active nanoceria in cancer therapeutics via oxidative stress Chapter 52. Nano technology in ROS induced cancer therapy. Chapter 53. Nanotechnology-based ROS triggered therapeutic strategies in cancer. Chapter 54. Nanotechnology in cancer diagnosis and therapy Chapter 55. Emerging Nano selenium: An insight to its current Status and potentials in ROS induced cancer Prevention and Therapy' Chapter 56. Oxidative Stress-dependent Anticancer Potentiality of Nano-therapeutic Zinc Oxide Section G: Bioinformatics and system biology approach for targeting ROS in cancer therapy Chapter 57 Molecular insights into the roles of E3 ligases in ROS mediated cancer from a bioinformatics perspective Chapter 58 Elucidation of possible role of heat shock protein as potent therapeutic agent in ROS mediated cancer and its assessment through computational biology methods. Chapter 59. Dynamical methods to study interaction in proteins facilitating molecular understanding of ROS induced cancer Chapter 60. Role of Meprin in therapeutics of ROS induced cancer Chapter 61. Different databases and their utilities to in analyzing ROS mediated cancer Section H: Other aspects of therapeutics of ROS induced cancer Chapter 62 A CRISPR-Cas based therapeutics in oxidative stress-induced cancer. Chapter 63. Role of hypoxia in ROS induced cancer therapy Chapter 64. Syed Ehtaishamul Haque < Chapter 65. Molecular mechanism of oxidative stress in cancer and its therapy Chapter 65. Pro-apoptotic effects of dietary flavonoids in oxidative stress-induced cancer. Chapter 66. Redox signalling: hallmarks of cancer progression and resistance to treatments Chapter 67 Mechanistic and therapeutic crosstalk of lipid peroxidation in oxidative stress and breast cancer. Chapter 68. Targeting Myeloid Leukemia via ROS and Oxidative Stress Chapter 69. Immunotherapeutic approaches for treatment of oxidative stress in haematological malignancies Chapter 70 Application of regulating ROS in overcoming cancer multidrug resistance Chapter 71. Y-Box binding protein 1: A promising therapeutic target for cancer relapses. Chapter 72. Microbes induced oxidative stress for cancer development and therapeutic role of probiotics Chapter 73. Implications of ROS in Endometriosis and Ovarian cancer: Potential avenue in cancer therapy. Chapter 74.Implications of oxidative stress in autophagy and its connection with apoptosis in carcinogenesis Chapter 75. Role of Forkhead box proteins regulating epithelial mesenchymal transition in breast cancer.

Read more less

Book SynopsisThis book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.Table of Contents1 Cancer Metabolism and Aggressive Tumor Behaviour.- 2 Immune Cell Metabolism and Function.- 3 Cancer Cell Metabolism Effecting Immune function.- 4 Immune Cell Metabolites as Fuel for Cancer Cells.- 5 Immuno-Onco metabolism and Resistance to Therapy.- 6 Targeting Immuno-Onco metaolism in Cancers.- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.

Read more less

Book SynopsisThis is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine. Special topics of interest and unique to the Arab world are also discussed, such as out of the country’s medical tourism for cancer care and cancer care during war and conflict. Other special chapters include: Cancer research in the Arab world, Radiation therapy in Arab World and Pediatric Oncology in the Arab World Cancer in the Arab World is the first comprehensive book that addresses cancer care in depth in all Arab countries and it is endorsed by the prestigious Emirates Oncology Society.Table of Contents 1 Introduction 2 General Oncology Care in Algeria 3 General Oncology Care in Bahrain 4 General Oncology Care in Egypt 5 General Oncology Care in Iraq 6 General Oncology Care in Jordan 7 General Oncology Care in Kuwait 8 General Oncology Care in Lebanon 9 General Oncology Care in Libya 10 General Oncology Care in Mauritania 11 General Oncology Care in Morocco 12 General Oncology Care in Oman 13 General Oncology Care in Palestine 14 General Oncology Care in the Kingdom of Saudi Arabia 15 General Oncology Care in Somalia 16 General Oncology Care in Sudan 17 General Oncology Care in Syria 18 General Oncology Care in Tunisia 19 General oncology care in the UAE 20 General Oncology Care in the Republic of Yemen 21 General Oncology Care in Qatar, Comoros & Djibouti 22 Breast Cancer in the Arab World 23 Colorectal Cancer in the Arab World 24 Palliative Care in the Arab World 25 Cancer Research in the Arab World 26 Pediatric Oncology in the Arab World 27 Challenges Associated with Medical Travel for Cancer Patients in the Arab World: A Systematic Review 28 Radiation Therapy in Arab World 29 Cancer Care During War and Conflict

Read more less

Book SynopsisThis is an Open Access book. This book is a must-have for healthcare providers and researchers, public health specialists and policy makers who are interested and involved in cancer care in the Arab world. The Arab world consists of 22 countries, which are members of the Arab League and spanning over 13,132,327 km2 with over 423,000,000 population. Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine. Special topics of interest and unique to the Arab world are also discussed, such as out of the country’s medical tourism for cancer care and cancer care during war and conflict. Other special chapters include: Cancer research in the Arab world, Radiation therapy in Arab World and Pediatric Oncology in the Arab World Cancer in the Arab World is the first comprehensive book that addresses cancer care in depth in all Arab countries and it is endorsed by the prestigious Emirates Oncology Society.Table of Contents 1 Introduction 2 General Oncology Care in Algeria 3 General Oncology Care in Bahrain 4 General Oncology Care in Egypt 5 General Oncology Care in Iraq 6 General Oncology Care in Jordan 7 General Oncology Care in Kuwait 8 General Oncology Care in Lebanon 9 General Oncology Care in Libya 10 General Oncology Care in Mauritania 11 General Oncology Care in Morocco 12 General Oncology Care in Oman 13 General Oncology Care in Palestine 14 General Oncology Care in the Kingdom of Saudi Arabia 15 General Oncology Care in Somalia 16 General Oncology Care in Sudan 17 General Oncology Care in Syria 18 General Oncology Care in Tunisia 19 General oncology care in the UAE 20 General Oncology Care in the Republic of Yemen 21 General Oncology Care in Qatar, Comoros & Djibouti 22 Breast Cancer in the Arab World 23 Colorectal Cancer in the Arab World 24 Palliative Care in the Arab World 25 Cancer Research in the Arab World 26 Pediatric Oncology in the Arab World 27 Challenges Associated with Medical Travel for Cancer Patients in the Arab World: A Systematic Review 28 Radiation Therapy in Arab World 29 Cancer Care During War and Conflict

Read more less

Book SynopsisThis book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.Table of ContentsChapter 1. Introduction to microRNAs and cancers.- Chapter 2. microRNAs and cancer signaling pathways.- Chapter 3. Role of microRNAs in cell growth proliferation and tumorigenesis.- Chapter 4. Impact of microRNAs in cell adhesion and tumor angiogenesis.- Chapter 5. Modulation of oxidative stress by microRNAs in cancers.- Chapter 6. microRNAs targeting tumor microenvironment and immune modulation.- Chapter 7. Circulating miRNA in prognosis, diagnosis and their role in controlling the fate of cancer stem cells.- Chapter 8. The role of miRNAs in the regulation of drug resistance among different cancers.- Chapter 9. The mechanisms of miRNA deregulation in cancer outbreak.- Chapter 10. Bioinformatic profiling of miRNAs in Cancers.

Read more less

Book SynopsisThe nanotheranostics sector provides a very promising strategy for monitoring drug biodistribution and pathology longitudinal processes by integrating the imaging and drug delivery functions in one single nanoformulation, providing vital insights into the identification of tumour and predicting the efficacy of nanomedicine. For its unique properties, which include their small size and biocompatibility and ability to permeate the cellular membrane with carrying drugs, nanomaterials have been used for various biomedical applications. This book covers the progress made in hormone-related cancer and their management by nonmedicinal therapy for targeting the hormone regulated cancer with their clinical progress and clinical hurdles.Table of ContentsChapter 1. Conventional Treatment Approaches in Hormonal Cancer Treatment and Challenges.- Chapter 2. Concept of Nanomedicine in Endocrine Hormone Cancer Treatment.- Chapter 3. Progress of Cancer Nanomedicine, Clinical Hurdles and Opportunities.- Chapter 4. Emergence of Nanohybrids in Hormonal Cancer Targeted Therapy.- Chapter 5. Conventional to Nanoscale-Based Carrier System in Management of Ovarian Cancer.- Chapter 6. Pancreatic Cancer Nanoparticles Targeted Therapy via Epidermal Growth Factor Receptor.- Chapter 7. Nanocarriers Based Targeted Therapies for Pancreatic Cancer and Challenges Ahead.- Chapter 8. Pancreatic Cancer Treatment by Using of Theranostics Nanoparticles.- Chapter 9. Nanomedicine Based Combinational Therapy for Breast Cancer.- Chapter 10. Nano-Liposomal System for Breast Cancer Therapy.- Chapter 11. Conventional to Nanotherapeutic Strategies against Triple-Negative Breast Cancer.- Chapter 12. Effect of Thymoquinone and Its Delivery Through Using of Nanomedicine in Benign Prostatic Hyperplasia.- Chapter 13. Concept of Nanotechnology in Management of Neuroendocrine Tumours.- Chapter 14. Neurocognitive Underpinning of Neurological Disorders: The Role of Default Mode Network.- Chapter 15. Neuroendocrine Carcinoma of The Endometrium: Conventional Treatment Approach to Nanomedicine.- Chapter 16. Effective Luteinizing Hormone Drug Delivery by Gold Nanoparticles in Hormonal Cancer Treatment.- Chapter 17. Regulatory Landscapes in Approval of Cancer Vaccines.

Read more less

Book SynopsisThis collection of chapters describes in detail the physical therapy research in patients with various types of cancers to help medical professionals and physical therapists help improve the physical function, activity of daily living, quality of life, the survival rate in cancer patients and cancer survivors. It provides not only information on rehabilitation but details on physical therapy cancer research and research methods. The book provides practical skills to treat the patients and to create useful and effective physical therapy programs by giving step-by-step tutorials to help readers learn various techniques. Along with presenting an introduction to physical therapy of cance and new findings, the authors provide recommendations on each cancer therapy. Physical Therapy and Research in Patients with Cancer is aimed at physical therapists and student physical therapists. Undergraduate and postgraduate students also can use our book to understand the basics and get up-to-date information. By sharing the latest research with our readers, the book creates a foundation for further development in this field of study. Table of ContentsPart 1 Physical Function and Health Related Quality of Life Chapter 1 Physical function and health related QOL in cancer survivors Chapter 2 Physical function and health-related quality of life after breast cancer surgery Chapter 3 Physical function and health-related quality of life in patients with gastrointestinal cancer Chapter 4 Physical function and health related QOL in surgically treated patients with malignant pleural mesothelioma Chapter 5 Muscle mass, cachexia, and health-related quality of life in patients with hematologic malignancies Chapter 6 Exercise capacity and health-related quality of life in patients after lung resection for non-small cell lung cancer Part 2 Physical Exercise Chapter 7 Effect of physical exercise on physical function and survival rate in cancer patients Chapter 8 Exercise therapy on muscle mass and physical function in patients undergoing allogeneic hematopoietic stem cell transplantation Chapter 9 Physical exercise and immune function in patients with hematological malignancies Chapter 10 Exercise protocols for counteracting cancer cachexia-related declines in muscle mass and strength and the clinical assessment of skeletal muscle Chapter 11 Physical Exercise and Skeletal Muscle Adaptation in Cancer Cachexia Chapter 12 Physical function and physical activity in patients with advanced lung cancer Chapter 13 Physical Activity in Patients with Breast Cancer Part 3 Physical Function and Other Symptom Chapter 14 Multiple frailty in elderly patients with cancer Chapter 15 Postoperative complications in patients with esophageal cancer Chapter 16 Cancer-related lymphedema and obesity Chapter 17 Cancer-related pain and effects of non-pharmacologic intervention Chapter 18 Nutrition and daily activities in older patients after gastrectomy Chapter 19 Frailty and mental health in older patients with gastrointestinal cancer Chapter 20 Physical function and nutrition in patients with hematological malignancies Chapter 21 Physical Function and Nutrition in Patients with Esophageal Cancer and Head and Neck Cancer Part 4 Skeletal Muscle Chapter 22 Skeletal muscle oxygenation in patients with malignant hematopoietic disease Chapter 23 Sarcopenia and physical performance in patients with cancer Chapter 24 Cachexia and postoperative outcomes in elderly patients with gastrointestinal cancer Chapter 25 Mechanism of skeletal muscle atrophy using a mice cancer cachexia model.

Read more less

Book SynopsisThis book tells the story of the discovery of microRNA (miRNA) quantum code, the basic theory of biological data science for medical investigation with miRNA, to its implementation. It explains the use of a new algorithm called the miRNA entangling target sorter (METS), based on the quantum computation algorithm, to give the etiologic analysis for diseases such as cancer, infectious diseases, and age-related disorders. Providing detailed descriptions to make the METS algorithm simple to grasp, it also explains the accumulated cutting-edged data for human diseases utilizing artificial intelligence (AI) for quantum miRNA language (miRNA qubit) (MIRAI). Further, it describes a discovery story for quantum miRNA surveillance against tumors and quantum miRNA immunity against viruses. Since this is a multidisciplinary field of study, crucial details on physics, mathematics, computer science, data science, virology, immunology, oncology, pathology, and biology are supplied.This book will support professional advancement for scientists, clinicians, educators, students, and science enthusiasts. The reader's knowledge of the subject and its practical medical applications will be enriched by the wealth of informative figures and supporting data.Table of ContentsRNA Controls RNA.- MicroRNA Qubit.- Matrix Multiplication for MicroRNA Qubit.- MicroRNA Quantum Computing.- Vital METS/MIRAI.- Etiologic Analysis for Human cancer.- Encounter with the unknown.- Diabetes Mellitus: Quantum microRNA Language with Artificial Intelligence (MIRAI) as an Early Diagnostic Tool for Type II Diabetes Mellitus for Sustainable Healthcare.- Thyroid Cancer: Quantum microRNA Language/Artificial Intelligence (MIRAI)-Based Etiologic Analysis of Thyroid Cancer by Serum/Plasma miRNA Panel Data.- Metabolic Disease and Alzheimer’s Disease.- Quantum MiRNA Immunity and Quantum MiRNA Surveillance.- Quantum MiRNA code.

Read more less

Book SynopsisThis book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer. ​Table of ContentsChapter 1 An introduction to breast cancer.- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators.- Chapter 4 Cell cycle and cancer.- Chapter 5 cell cycle dysregulation in breast cancer.- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation.- Chapter 7 Breast tumor micro environment and CDks.- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis.- Chapter 9 CDK1 Dysregulation in Breast Cancer.- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers.- Chapter 11 Therapeutic implications of CDKs in Breast Cancer.- Chapter 12 Novel CDK Inhibitors in Breast Cancer.- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach.- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer.- Chapter 15 CDk inhibitor for treatment of breast cancer.- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer.- Chapter 17 Different cyclins and their significance in Breast cancer.

Read more less

Book SynopsisThis book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs.Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes.This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.Table of ContentsStrategies for Cancer Targeting: Novel Drug Delivery Systems Opportunities and Future Challenges.- Implementation of Biomedical Engineering Tools in Targeted Cancer Therapy: Challenges and Opportunities.- Exploration of tissue-engineered systems for cancer research.- Advancement of Tissue Engineered in Cancer treatment.- Immunotherapy: Targeting Cancer Cells.- Bioinformatics Tools to Discover and Validate Cancer Biomarkers.- Application of Biomaterials in Cancer Research.- Engineered Tissue in Cancer Research: Techniques, Challenges and Current status.- CADD for Cancer Therapy: Current and Future Perspective.- Leveraging Advancement in Robotics in the Treatment of Cancer.-Innovative Biomedical Equipment for Diagnosis of Cancer.- Detection of Cancer Biomarker by Advanced Biosensor.- Advancement of Nanocarrier Based Engineering for Specific Drug Delivery for Cancer Therapy.- Nano-Drug Delivery Systems for Tumor-Targeting: Overcoming the Limitations of Chemotherapy.- Microfluidics and cancer treatment: Emerging concept of Biomedical Engineering.- Recent Developments In Two-Dimensional (2D) Inorganic Nanomaterials-Based Photo-Thermal Therapy for Cancer Theranostics.- Cyclodextrins and Cyclodextrin-Based Nanosponges for Anti-Cancer Drug and Nutraceutical Delivery.- Theranostic Approaches for Diagnosis and Treatment of Cancer: An Update.- MicroRNA Biomarkers for Oral Cancer: A Meta-Analytic Review.- Application of Magnetic Nanoparticles in Cancer: Drug Delivery and Therapy.- Vehicles for Delivery of Therapeutic Agent for Cancer Therapy.- Photothermal Therapy for Cancer Treatment.- Tool and Techniques on Computer -Aided Drug Design for Targeted Cancer Therapy.- Importance of Gut Microbiome-based Therapeutics in Cancer Treatment.- Computational Tools for Drug Discovery of Anticancer Therapy.- Stem Cell Therapy in Cancer

Read more less

Book SynopsisThis book discusses the contribution of genetics and epigenetics alterations in the initiation, development, and recurrence of breast cancer. Further, the book explores the potential of epigenetic drugs in treating breast cancer.

Read more less

Book SynopsisGynaecologic oncology is one of the most important subjects in gynaecology and a very challenging field. The management of patients with gynaecological cancers is complex, as the impact of the outcome of such cancers can be critical. This handbook covers the basics of carcinogenesis and the advances in the prevention and management of all gynaecologic cancers, including breast cancer. Gynaecologic oncology has always been perceived as the most difficult subject in obstetrics and gynaecology, but this handbook proves it otherwise. The text is presented in a systematic and easy-to-understand manner and is supplemented by plenty of images and illustrations and up-to-date references from established sources. The book also introduces readers to the new FIGO 2009 staging system and will be a very useful reference for researchers and clinicians.Trade Review"This comprehensive handbook covers the essentials of gynaecological oncology. The text includes all pelvic tumours as well as breast cancer, cancer in pregnancy, and fertility-sparing possibilities. It outlines well the complications of treatment with the basics of radiotherapy and chemotherapy. This is a good book for the aspiring junior doctor to have as a guide for current clinical practice and to review before ‘that exam’. A well-worth buy!"Prof. John H. Shepherd, Royal Marsden Hospital, UK"This book presents a comprehensive collection of information on gynaecologic oncology in a systematic and easy-to-understand manner. I am convinced that students, young gynaecologists, and gynaecologic oncologists will enjoy reading this informative text."Dr. Shingo Fujii, Kitano Hospital, JapanTable of ContentsWorld Cancer Statistics and Burden of Gynae Cancer. Genes and Carcinogenesis. Cancer of Vulva. Cancer of Vagina. Screening for Cervical Cancer. Human Papillomavirus and HPV Vaccine. Management of Pre-invasive Disease of Cervix. Cancer of Cervix. Cancer of Endometrium. Uterine Sarcoma. Cancer of Fallopian tube. Cancer of Ovary (Epithelial). Ovarian Germ Cell Tumours. Ovarian Sex Cord Stromal Tumours. Gestational Trophoblastic Disease. Breast Cancer for Gynaecologic Oncologist. Gynaecologic Cancer in Pregnancy. Tumour Markers in Gynaecologic Oncology. Diagnostic Imaging in Gynaecologic Oncology. Peri-operative Care for Gynaecologic Cancer Patients. Basic Anatomy and Principles of Surgery in Gynae Oncology. Basic Principles of Radiotherapy. Basic Principles of Chemotherapy. Modulating Agents,Response Modifier and Targeted Therapy. Immunotherapy and Hormonal Therapy. Management of Long-term Side Effects of Gynae Cancer Treatment. Nutritional Support For Gynaecologic Cancer Patients. Basic Surgical Procedures in Gynaecologic Oncology. Laparoscopic and Robotic Surgery in Gynaecologic Cancers. Index.

Read more less

Book SynopsisThe main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.Table of ContentsPart 1: Multifunctional Agents for Cancer-Imaging and Photodynamic Therapy: Monomers vs. Polyacrylamide-Based Nanoplatforms (Aimee Marko, Nayan J Patel, Penny Joshi, Joseph R Missert and Ravindra K Pandey); Design and Synthesis of Photosensitizers-peptide conjugates for PDT (Turslai M Williams, Martha Sibrian-Vazquez and M Graca H Vicente); Current Devcelopments in Using Meso (tetra) Substituted Porphyrins in PDT (Yasser M Shaker, Ayman M K Sweed, Claire Moylan, Luke Rogers, Aoife A Ryan, Rosine Petitdemange and Mathias O Senge); (Mike Detty et al.); Phthalocyanines in Cancer-Imaging and Therapy (Hasrat Ali and Johan E van Lier); Molecular Phthalocyanines-Based Photosensitizers for Photodynamic Therapy (Pui-Chi Lo, Sun Y S Chow and Dennis K P Ng); Porphyrin Nanoparticles for cancer Imaging and Photodynamic Therapy (Liyang Cui, Juan Chen and Gang Zheng); Photodynamic Therapy Dosimetry: A to Z (Michael S Patterson); Part 2: PDT: Death and Survival Pathways (David Kessel); Vascular Effect of Photodynamic Therapy of Tumors (Keith A Cengel, Charles B Simone and Theresa M Busch); ETNBS in Photodynamic Therapy (Nicholas H Nowell, Hsin-I Hung, Lauren A Austin and Conor L Evans); Negative Impact of Tumor-Generated Nitric Oxide on Photodtynamic Therapy (Albert W Girotti); On the use of Photodynamic Therapy, as Monotherapy or in Combination, in the Treatment of Polypoidal Choroidal Vasculopathy: an Update (Hubert van den bergh and Patrycja Nowak-Sliwinska); Part 3: Photodynamic Therapy of Head and Neck Cancer - What's Old and What's New (Merrill A Biel); Endoscopic Photodynamic Therapy for Advanced Inoperable Esophageal Cancer; PDT for Lung Cancer (Keishi Ohtani and Norihiko Ikeda); New Developments in Antimicrobial PDT (Wolfgang Baumler by Joerg Lindenmann);

Read more less

Book SynopsisNanomaterials have the potential to shift the paradigm for the diagnosis and treatment of many diseases, especially neoplasms, because of the intriguing behaviors associated with their unique size-/shape-influenced chemical, physical, and physiological features. Currently, there is a huge imbalance between the several nanoplatforms reported in the literature and the few ones approved for clinical applications. This disequilibrium affects, in particular, plasmonic nanomaterials, which present no approved platforms and few candidates in clinical trials. This trend can be reversed by promoting collaborations among scientists from different fields as well as by improving the multidisciplinary background of researchers interested in this area. This book is a collection of must-read peer-reviewed papers focusing on (i) the main behaviors of nanomaterials for nanomedicine, (ii) key features nanomaterials need for successful translation to the clinical setting, and (iii) market analysis of nanomaterials at the bedside or on the way. The main aim of this book is to offer a comprehensive point of view to students and researchers in order to promote the translation of new technologies to patients. It is a unique reference for advanced undergraduate- and graduate-level students of nanotechnology and researchers in materials science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in cancer theranostics.Table of ContentsDetecting and Destroying Cancer Cells in More Than One Way with Noble Metals and Different Confinement Properties on the Nanoscale. Engineered Nanoparticles for Drug Delivery in Cancer Therapy. Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles. Gold Nanomaterials at Work in Biomedicine. The Nanomedicines Alliance: An Industry Perspective on Nanomedicines. Nanomedicine(s) under the Microscope. Imaging Nano–Bio Interactions in the Kidney: Toward a Better Understanding of Nanoparticle Clearance. Nanomaterials for Theranostics: Recent Advances and Future Challenges. Metabolism of Nanomaterials in vivo: Blood Circulation and Organ Clearance.

Read more less

Book Synopsis

Read more less

Book Synopsis.- Chapter 1: Structural features and Signaling mechanisms of Receptor Tyrosine Kinases in Cancer.- Chapter 2: Cell Death Pathways in Cancer and Potential Therapeutic Targets.- Chapter 3: Telomerase as a Target for Cancer Therapy  .- Chapter 4: Molecular targets of epigenetic regulators.- Chapter 5: Signaling Pathways in Cancer Drug Resistance: Potential Targets for Therapeutic Intervention  .- Chapter 6: Targeting Angiogenesis for Cancer Prevention and Therapy     .- Chapter 7: Inflammation as a target in cancer therapy.- Chapter 8: Epithelial-Mesenchymal Transition: Insights into Molecular Pathways and Cancer Therapeutics.- Chapter 9: Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy .- Chapter 10:Genomic instability as a Therapeutic Target: Advancements from Experimental Research to Clinical Application.- Chapter 11:Targeting innate immunity: A New Door to Cancer Therapy .- Chapter 12:Metabolic Targeting in Cancer Therapy: Strategies, Challenges, and Personalized Approaches.

Read more less

Book Synopsis.- Chapter 1_The Microbiome And Cancer: Understanding The Role Of Microorganisms In Tumor Development And Treatment..- Chapter 2_Microbiome And Its Impact On Human Health: Microbiome In Various Body Organs And Its Association With Human Health And Disease..- Chapter 3_Viral Infections And Different Cancers..- Chapter 4_Role Of Hcv In Hepatocellular Carcinoma..- Chapter 5_Cancers Associated With Epstein-Barr Virus..- Chapter 6_Human Papillomavirus Leading To Urogenital, Head And Neck Cancer..- Chapter 7_Kaposi's Sarcoma Associated Herpes Virus..- Chapter 8_Cancer And Fungal Infections..- Chapter 9_Microorganisms And Other Cancers..- Chapter 10_Protists And Cancer..- Chapter 11_Cancer Management And Therapies Related To Microorganisms.

Read more less

Book SynopsisThis book describes the use of stem cells and cancer stem cell generation in the inflammatory microenvironment (cancer-inducing niche) using induced pluripotent stem cells. It provides step-by-step techniques and manuals for studying stem cell and cancer stem cell generation with different applications in cancer research. The development of induced pluripotent stem cells has provided a new approach to studying cancer initiation by producing cancer stem cells without introducing mutations or foreign genes. The book features the research of the authors’ group, which was the first to generate cancer stem cells from stem cells in the presence of inflammatory conditions. The 20 chapters of this book cover topics such as generating pluripotent stem cells, converting normal stem cells to cancer stem cells, enriching, isolating and evaluating cancer stem cells. Methods for evaluating the characteristics of cancer stem cells and possible therapies against them are also discussed. The book provides easy-to-follow protocols that help researchers in the study of cancer stem cells. Illustrations help readers understand how the method of cancer stem cell generation can be applied as an essential method for assessing the carcinogenic potential of various non-mutagenic compounds. It will be a useful resource for graduate students, researchers, technicians, and physicians working in academic, hospital, and pharmaceutical settings. Table of Contents1. On the origin of cancer.- 2. Culture of Cells: Basic Principles .- 3. Stem cell culture from embryos.- 4. Reprogramming of normal cells.- 5. Maintenance of human Pluripotent Stem Cells.- 6. Identification of cancer stem cells by different molecular markers .- 7. Enrichment of Cancer Stem Cell from malignant tumor.- 8. Isolation of single clonal cell from primary cultured cells and establishment of a cancer stem cell line .- 9. Artificial Generation of Cancer Stem Cells from Normal Stem Cells.- 10. Quick method to assess non-mutagenic carcinogens with iPS cells.- 11. Self-renewal potential of caner stem cells.- 12. Differentiation potential of cancer stem cells in vitro.- 13. Tumor Angiogenesis by cancer stem cells in vivo.- 14. Invasion and Metastatic potential of cancer stem cells in vitro.- 15. Metastatic potential of cancer stem cells In Vivo- 16. Anchorage-independent cell growth assay for Cancer Stem Cells: Tumorigenic assay in vitro .- 17. Tumorigenic potential of cancer stem cells in vivo.- 18. Development of immunoliposomes using monoclonal antibodies targeting cancer stem cells .- 19. In-vitro evaluation of anti-cancer stem cell drugs .- 20. In vitro Tumoroid Model Using Cancer Stem Cells.

Read more less

Book SynopsisThis book comprises select proceedings of the workshop “Practical inverse problems and their prospects” held online by zoom, from Mar 2nd to Mar. 4th, 2022, supported by Institute of Mathematics for Industry, Kyushu University focusing on cutting-edge research carried out in the areas of practical inverse problems based on industry-academia and interdisciplinary collaborations.Various themes on practical inverse problems covered in this book are medical imaging, non-destructive and non-invasive inspections, viscoelastic waves, remote sensing, infrared light tomography, maintenance of infrastructure, and so on, and mathematical theories in inverse problems are also handled in these proceedings.All papers in this book are written by qualified authors in the practical inverse problems area and also the papers are newly announced. Readers can get leading-edge information on practical inverse problems.Table of Contents

Read more less

Book SynopsisWritten by experts from the globally renowned Tata Memorial Centre (TMC) in Mumbai, this book provides a crisp and highly distilled review of clinical aspects of oncology, primarily for postgraduate students and fellows. TMC Textbook of Oncology covers the basic principles of oncology, solid tumors, hematologic cancers, and special topics such as oncological emergencies, pain management, intensive care, and the impact of comorbidities. Chapters have been structured uniformly covering epidemiology, clinical presentation and evaluation, principles of multidisciplinary management and stage-wise management and prognosis. Each chapter has been further extensively reviewed by an eminent national or international expert.This textbook is an extension of the annual Evidence Based Meetings that TMC has conducted since 2002, wherein experts have distilled the evidence for diagnostic and therapeutic strategies in oncology not only on strength of evidence but also on applicability in a variety of settings. The Textbook will provide the reader with a glimpse into the clinical decision-making process at TMC, which is an institution that provides cancer care to all sections of the society.An essential read for all students and practitioners in this field as a reference as well as practical aid in clinical decision making. Table of ContentsPart I. Basic Principles.- Chapter 1. Basic and Translational Science in Oncology.- Chapter 2. Principles of Surgical Oncology.- Chapter 3. Radiation Oncology.- Chapter 4. Principles of Systemic Treatment of Cancer.- Chapter 5. General Overview of Pediatric Oncology: Epidemiology and Challenges in Childhood.- Chapter 6. Principles of Oncopathology.- Chapter 7. Oncologic Hematopathology.- Chapter 8. Microbiology in Oncology.- Chapter 9. Principles of Imaging in Oncology.- Chapter 10. Nuclear Medicine in Oncology.- Chapter 11. Interventional Radiology in Oncology.- Chapter 12. Anaesthesia in Oncology.- Chapter 13. Transfusion Medicine in Oncology.- Chapter 14. Palliative Care in Oncology.- Chapter 15. Clinical Pharmacology in Oncology.- Chapter 16. Cancer Staging.- Part II. Public Health.- Chapter 17. Cancer Registration in India: A Tool to Estimate Incidence and Mortality.- Chapter 18. Cancer Screening in India.- Part III. Hematological Malignancies.- Chapter 19. Adult Lymphoblastic Leukemias.- Chapter 20. Adult Lymphomas.- Chapter 21. Adult Myeloproliferative Disorders/ Myelodysplastic Syndromes/Overlap Syndromes.- Chapter 22. Plasma Cell Dyscrasia.- Chapter 23. Immunodeficiency-associated Lymphoproliferative Disorders.- Chapter 24. Histiocytic and Dendritic Cell Neoplasms.- Chapter 25. Pediatric Acute Leukemias.- Chapter 26. Pediatric Hodgkin Lymphoma.- Chapter 27. Pediatric Myeloproliferative Disorders /Myelodysplastic Syndromes/Overlap Syndromes.- Chapter 28. Hematopoietic Stem Cell Transplantation.- Part IV. Solid Tumors.- Chapter 29. Central Nervous System (CNS) Tumours.- Chapter 30. Head and Neck Cancers.- Chapter 31. Thyroid and Parathyroid Cancer.- Chapter 32. Management of Breast Cancer.- Chapter 33. Non-Small Cell Lung Cancer.- Chapter 34. Small Cell Lung Cancer (SCLC).- Chapter 35. Mediastinal Tumours.- Chapter 36. Esophageal Cancer.- Chapter 37. Biliary Tract Cancer.- Chapter 38. Liver Cancer.- Chapter 39. Gastric Cancer.- Chapter 40. Colon Cancer.- Chapter 41. Small Intestine Cancer.- Chapter 42. Anal Canal Cancer.- Chapter 43. Pancreatic Cancer.- Chapter 44. Gastrointestinal Stromal Tumor.- Chapter 45. Gastroentero-pancreatic Neuroendocrine Tumours.- Chapter 46. Rectal Cancer.- Chapter 47. Renal Cancer.- Chapter 48. Adrenal Cancer.- Chapter 49. Urinary Bladder Cancer.- Chapter 50. Upper Tract Urothelial Cancer.- Chapter 51. Prostate Cancer.- Chapter 52. Penile Cancer.- Chapter 53.Testicular Cancer.- Chapter 54. Uterine Cancer.- Chapter 55. Cervical Cancer.- Chapter 56. Vulva and Vaginal Cancers.- Chapter 57. Gestational Trophoblastic Disease.- Chapter 58. Epithelial Ovarian Cancer.- Chapter 59. Non-Epithelial Ovarian Cancer.- Chapter 60. Bone Sarcomas.- Chapter 61. Soft Tissue Sarcoma: Principles of Management.- Chapter 62. Ewing Sarcoma.- Chapter 63. Wilms Tumor.- Chapter 64. Neuroblastoma.- Chapter 65. Retinoblastoma.- Chapter 66. Rare Pediatric Tumors.- Chapter 67. Childhood and Adolescent Extracranial Germ Cell Tumors.- Chapter 68. Hepatoblastoma.- Part V. Special Topics.- Chapter 69. Oncological Emergencies.- Chapter 70. Pain Management in Oncology.- Chapter 71. Intensive Care in Oncology.- Chapter 72. Vascular Access in Oncology.- Chapter 73. Comorbidities in the Cancer Patient.- Chapter 74. Hereditary Cancers: Genetic Counselling, Genetic Testing and Risk Management.- Chapter 75. Library and Information Needs in Oncology: In Pursuit of Information.- Chapter 76. Oncology Training and Education in India: The Tata Memorial Centre (TMC) Perspective.

Read more less

Book SynopsisChapter 1. Molecular Biomarkers of Cancer and their Diagnostic Applications.- Chapter 2. Statistical Models in Cancer Management.- Chapter 3. Deep Learning Techniques for Computer Aided Diagnosis of Various Cancers.- Chapter 4. Machine Learning Techniques in Computer Aided Diagnosis for Effective Detection of Malignant Tissues.- Chapter 5. Molecular Mechanisms of Oncogenesis.- Chapter 6. Application of CRISPR in Cancer Research and Treatment.- Chapter 7. Nanobiosensing Platforms for Early Detection of Cancer.- Chapter 8. Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy.- Chapter 9. Central Nervous System Tumors.- Chapter 10. Biomedical Approaches in the Research and Management of Head and Neck Squamous Cell Carcinoma.- Chapter 11. Applications of Molecular Biology and Biomedical Advances in Ocular Oncology.- Chapter 12. Molecular Markers in Oral Cancer.- Chapter 13. MicroRNAs as Tools for Early Diagnosis and Predicting Response to Therapy in Oe

Read more less

Book SynopsisThis book covers a comprehensive update on acute and chronic leukemia. In 54 chapters, authors introduce research progress and clinical trials of acute myeloid leukaemia (AML), acute promyelocytic leukaemia (APL), acute lymphoblastic leukaemia (ALL), myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and chronic myeloid leukemia (CML). The last decade has seen the integration of genetic and clinical information to determine the prognosis and treatment strategies. This book provides practitioners, researchers and graduate students of Hematology and Hematopathology a comprehensive update on the pathobiology, genomics, classification, diagnosis, monitoring, prognostication and therapy of both acute and chronic leukemias.Table of ContentsChapter 1 Basic haematopoiesis and leukemia stem cells Chapter 2 Modern classification of acute and chronic leukemias: integrating biology, clinicopathologic features and genomics Chapter 3 Molecular techniques in the diagnosis and monitoring of acute and chronic leukemias Chapter 4 Flow cytometric techniques in the diagnosis and monitoring of acute leukemias Chapter 5 Genomic Landscape and Risk Stratification of Acute Myeloid Leukemia Chapter 6 Frontline management of acute myeloid leukaemia eligible for intensive chemotherapy Chapter 7 Frontline management of elderly acute myeloid leukemia ineligible for intensive treatment Chapter 8 Management of Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia Chapter 9 Management of relapsed or refractory AML Chapter 10 The Role of BCL-2 / MCL-1 targeting in Acute Myeloid Leukemia Chapter 11 Role of IDH1/IDH2 inhibitors in AML Chapter 12 Next-generation FLT3 inhibitors for the treatment of FLT3-positive AML Chapter 13 Allogeneic hematopoietic stem cell transplantation for AML Chapter 14 Maintenance therapy following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia Chapter 15 Immunotherapeutic targeting of AML Chapter 16 In the pipeline – Emerging therapy for acute myeloid leukaemia Chapter 17 Frontline management of acute promyelocytic leukemia Chapter 18 Management of relapsed acute promyelocyticleukemia and the role of hematopoietic stem cell transplantation Chapter 19 Genomic Landscape of Acute Lymphoblastic Leukaemia (ALL) – Insights to Leukaemogenesis, Prognostications and Treatment Chapter 20 Management of adolescent and young adults with Acute Lymphoblastic Leukaemia Chapter 21 Management of older patients with acute lymphoblastic leukemia Chapter 22 Management of Philadelphia Chromosome-positive Acute Lymphoblastic Leukaemia Chapter 23 Management of Philadelphia Chromosome-like Acute Lymphoblastic Leukemia (Ph-like ALL) Chapter 24 Allogeneic Hematopoietic Stem Cell Transplantation for Acute Lymphoblastic Leukemia Chapter 25 Immunotherapy for ALL Chapter 26 In the Pipeline - Emerging therapy for ALL Chapter 27 Inherited/genetic predisposition to MDS and AML Chapter 28 Clonal hematopoiesis and its functional implications in MDS/AML Chapter 29 Therapy-related MDS/AML and the role of environmental factors Chapter 30 Prognostic indicators in MDS and CMML Chapter 31 Treatment algorithm of myelodysplastic syndromes Chapter 32 Treatment algorithm of CMML and other uncommon MDS/MPN subtypes Chapter 33 Novel strategies to manage cytopenia in low-risk MDS Chapter 34 Allogeneic hematopoietic stem cell transplantation for MDS and CMML: when and how? Chapter 35 In the Pipeline - Emerging therapy for MDS and MDS/MPN Chapter 36 Molecular landscape and personalized prognostic prediction of MPNs Chapter 37 Treatment algorithm of polycythemia Vera Chapter 38 Treatment algorithm of essential thrombocythemia Chapter 39 Prognostic models for primary and secondary myelofibrosis Chapter 40 Treatment algorithm for primary and secondary myelofibrosis Chapter 41 Diagnosis and management of prefibrotic primary myelofibrosis (pre-PMF) Chapter 42 Interferons In myeloproliferative neoplasms Chapter 43 JAK inhibitors for the management of myeloproliferative neoplasms Chapter 44 Allogeneic hematopoietic stem cell transplantation for myelofibrosis – when and how? Chapter 45 Thrombosis and myeloproliferative neoplasms Chapter 46 Eosinophilic disorders and systemic mastocytosis Chapter 47 In the Pipeline - Emerging therapy for classical Ph-negative MPNs Chapter 48 "Current guidelines and treatment algorithm of chronic myeloid leukaemia" Chapter 49 Treatment-free remission in chronic myeloid leukemia Chapter 50 Treatment options in CML resistant or intolerant to second-generation tyrosine kinase inhibitors Chapter 51 Allogeneic hematopoietic cell transplantation in CML: when and how? Chapter 52 In the Pipeline - Emerging therapy for CML

Read more less

Book SynopsisThis book systematically covers diagnostic imaging of lung cancers, including epithelial tumors, mesenchymal tumors, and hematolymphoid tumors, with emphasis on relationship between classification, molecular pathology, clinical findings, imaging manifestations and pathological discussion.

Read more less

Book SynopsisThis book provides a practical overview of a central topic in cervical cancer concerning human papillomavirus (HPV), prevention, cervical cancer screening, diagnosis, and treatment.

Read more less

Book SynopsisThis volume includes eight chapters that describe recent updates in cancer research. Chapter One highlights the benefits of ancillary/consulting care services within pediatric oncology, including social work, psychology, neuropsychology, expressive therapies, child life, chaplaincy, teachers/school liaisons, rehabilitation therapies, nutrition, and palliative care. Chapter Two discusses various generations of chimeric antigen receptors (CAR) and recent efforts in manufacturing CAR T-cells as a therapy for cancer treatment. Chapter Three explores alternative target pathways for putative therapeutic approaches affecting chronic myeloid leukemia cells. Chapter Four reviews research done on the role of epigenetics in the initiation and progression of thyroid cancer. Chapter Five summarizes the literature that implicates the underlying molecular mechanisms of paclitaxel resistance and the potential therapeutic targets to overcome this resistance. Chapter Six deals with the inhibition of autophagy for instigating temozolomide for increasing induction of apoptosis in glioblastoma. Chapter Seven studies the use of vitamin E for leukemic stem cells reprogramming. Finally, Chapter Eight describes new molecular studies for approaches affecting chronic myeloid leukemia cells.

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less

Book Synopsis

Read more less