Molecular biology Books
MIT Press Ltd Quantitative Fundamentals of Molecular and
Book SynopsisA comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena.This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering.The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After i
£68.40
W. W. Norton & Company Zika The Emerging Epidemic
Book Synopsis
£21.21
John Wiley and Sons Ltd Handbook of Molecular Microbial Ecology II
Book SynopsisThe premiere two-volume reference on revelations from studying complex microbial communities in many distinct habitats Metagenomics is an emerging field that has changed the way microbiologists study microorganisms. It involves the genomic analysis of microorganisms by extraction and cloning of DNA from a group of microorganisms, or the direct use of the purified DNA or RNA for sequencing, which allows scientists to bypass the usual protocol of isolating and culturing individual microbial species. This method is now used in laboratories across the globe to study microorganism diversity and for isolating novel medical and industrial compounds. Handbook of Molecular Microbial Ecology is the first comprehensive two-volume reference to cover unculturable microorganisms in a large variety of habitats, which could not previously have been analyzed without metagenomic methodology. It features review articles as well as a large number of case studies, based largely on oTrade Review"Handbook of Molecular Microbial Ecology II is an invaluable reference for researchers in metagenomics, microbial ecology, microbiology; those working on the Human Microbiome Project; microbial geneticists; and professionals in molecular microbiology and bioinformatics." (Bois et Forets des Tropiques, 2011)“Handbook of Molecular Microbial Ecology II is an invaluable reference for researchers in metagenomics, microbial ecology, microbiology; those working on the Human Microbiome Project; microbial geneticists; and professionals in molecular microbiology and bioinformatics.” (Bois et Forets des Tropiques, 2011) Table of ContentsPreface xiii Contributors xv 1. Introduction 1 Frans J. de Bruijn Part 1 Viral Genomes 2. Viral Metagenomics 5 Shannon J. Williamson 3. Methods in Viral Metagenomics 15 Rebecca Vega Thurber 4. Metagenomic Contrasts of Viruses in Soil and Aquatic Environments 25 K. Eric Wommack, Sharath Srinivasiah, Mark R. Liles, Jaysheel Bhavsar, Shellie Bench, Kurt E. Williamson, and Shawn W. Polson 5. Biodiversity and Biogeography of Phages in Modern Stromatolites and Thrombolites 37 Christelle Desnues, Beltran Rodriguez-Brito, Steve Rayhawk, Scott Kelley, Tuong Tran, Matthew Haynes, Hong Liu, Mike Furlan, Linda Wegley, Betty Chau, Yijun Ruan, Dana Hall, Florent E. Angly, Robert A. Edwards, Linlin Li, Rebecca Vega Thurber, R. Pamela Reid, Janet Siefert, Valeria Souza, David L. Valentine, Brandon K. Swan, Mya Breitbart, and Forest Rohwer 6. Assembly of Viral Metagenomes from Yellowstone Hot Springs Reveals Phylogenetic Relationships and Host Co-Evolution 45 Thomas W. Schoenfeld and David Mead 7. Next-Generation Sequencing and Metagenomic Analysis: A Universal Diagnostic Tool in Plant Pathology 63 Ian P. Adams, Rachel H. Glover, Wendy A. Monger, Richard Thwaites, Rick Mumford, Elena Jackeviciene, Meletele Navalinskiene, Marija Samuitiene, and Neil Boonham 8. Direct Metagenomic Detection of Viral Pathogens in Human Specimens Using an Unbiased High-Throughput Sequencing Approach 73 Takaaki Nakaya, Shota Nakamura, Yoshiko Okamoto, Yoshiyuki Nagai, Jun Kawai, Yoshihide Hayashizaki, Tetsuya Iida, and Toshihiro Horii Part 2 The Soil Habitat 9. Soil-Based Metagenomics 83 Rolf Daniel 10. Methods in Metagenomic DNA, RNA, and Protein Isolation from Soil 93 T. Rajesh, J. Rajendhran, P. Lavanya Pushpam, and P. Gunasekaran 11. Soil Microbial DNA Purification Strategies for Multiple Metagenomic Applications 109 Larissa C. Parsley, Chengcang Wu, David Mead, Robert M. Goodman, and Mark R. Liles 12. Application of PCR-DGGE and MetagenomeWalking to Retrieve Full-Length Functional Genes from Soil 117 Sho Morimoto and Takeshi Fujii 13. Actinobacterial Diversity Associated with Antarctic Dry Valley Mineral Soils 125 Bronwyn M. Kirby, Marilize Le Roes-Hill, S. Craig Cary, Stephanie G. Burton, I. Marla Tuffin, and Don A. Cowan 14. Targeting Major Soil-Borne Bacterial Lineages Using Large-Insert Metagenomic Approaches 135 Anna M. Kielak and George A. Kowalchuk 15. Novelty and Uniqueness Patterns of Rare Members of the Soil Biosphere 143 Mostafa S. Elshahed and Noha H. Youssef 16. Extensive Phylogenetic Analysis of a Soil Bacterial Community Illustrates Extreme Taxon Evenness and the Effects of Amplicon Length, Degree of Coverage, and DNA Fractionation on Classification and Ecological Parameters 151 Sergio E. Morales, Theodore F. Cosart, Jesse V. Johnson, and William E. Holben 17. The Antibiotic Resistome: Origins, Diversity, and Future Prospects 165 Erin L.Westman and Gerard D.Wright Part 3 The Digestive Tract 18. Functional Intestinal Metagenomics 177 Bartholomeus van den Bogert, Milkha M. Leimena, Willem M. de Vos, Erwin G. Zoetendal, and Michiel Kleerebezem 19. Assessment and Improvement of Methods for Microbial DNA Preparation from Fecal Samples 191 Mariko Ueno, Mami Kikuchi, Kenshiro Oshima, Seok-won Kim, Hidetoshi Morita, and Masahira Hattori 20. The Role of Dysbiosis in Inflammatory Bowel Diseases 199 Johan Dicksved and Ben Willing 21. Culture-Independent Analysis of the Human Gut Microbiota and their Activities 207 Jonathan Swann, Selena E. Richards, Qing Shen, Elaine Holmes, Julian R. Marchesi, and Kieran Tuohy 22. Complete Genome of an Uncultured Endosymbiont Coupling Nitrogen Fixation to Cellulolysis within Protist Cells in Termite Gut 221 Yuichi Hongoh 23. Cloning and Identification of Genes Encoding Acidic Cellulases from the Metagenomes of Buffalo Rumen 229 Cheng-Jie Duan, Jun-Liang Liu, and Jia-Xun Feng Part 4 Marines and Lakes 24. Microbial Diversity in the Deep Sea and the Underexplored “Rare Biosphere” 245 David B. Mark Welch and Susan M. Huse 25. Bacterial Community Structure and Dynamics in a Seasonally Anoxic Fjord: Saanich Inlet, British Columbia 253 David A. Walsh and Steven J. Hallam 26. Adaptation to Nutrient Availability in Marine Microorganisms by Gene Gain and Loss 269 Adam C. Martiny, Ying Huang, and Weizhong Li 27. Detection of Large Numbers of Novel Sequences in the Metatranscriptomes of Complex Marine Microbial Communities 277 Jack A. Gilbert, Dawn Field, Ying Huang, Robert A. Edwards, Weizhong Li, Paul Gilna, and Ian Joint 28. Metagenomic Approach Studying the Taxonomic and Functional Diversity of the Bacterial Community in a Lacustrine Ecosystem 287 Didier Debroas, Fran¸cois Enault, Isabelle Jouan-Dufournel, Gis`ele Bronner, and Jean-Fran¸cois Humbert 29. Metagenomics of the Marine Subsurface: The First Glimpse from the Peru Margin, ODP Site 1229 295 Jennifer F. Biddle 30. A Targeted Metagenomic Approach to Determine the “Population Genome” of Marine Synechococcus 301 Sophie Mazard, Martin Ostrowski, Laurence Garczarek, and David J. Scanlan 31. Diversity and Role of Bacterial Integron/Gene Cassette Metagenome in Extreme Marine Environments 309 Hosam Elsaied and Akihiko Maruyama Part 5 Other Habitats 32. The Olavius algarvensis Metagenome Revisited: Lessons Learned from the Analysis of the Low-Diversity Microbial Consortium of a Gutless Marine Worm 321 Manuel Kleiner, Tanja Woyke, Caroline Ruehland, and Nicole Dubilier 33. Microbiome Diversity in Human Saliva 335 Ivan Nasidze and Mark Stoneking 34. Approaches to Understanding Population Level Functional Diversity in a Microbial Community 341 Devaki Bhaya 35. A Functional Metagenomic Approach for Discovering Nickel Resistance Genes from the Rhizosphere of an Acid Mine Drainage Environment 355 Salvador Mirete, Carolina G. de Figueras, and Jose E. Gonz´alez-Pastor 36. The Microbiome of Leaf-Cutter Ant Fungus Gardens 367 Garret Suen, Jarrod J. Scott, Frank O. Aylward, and Cameron R. Currie 37. Diversity of Archaea in Terrestrial Hot Springs and Role in Ammonia Oxidation 381 Chuanlun L. Zhang, Brian P. Hedlund, and Jun Meng 38. Colonization of Nascent, Deep-Sea Hydrothermal Vents by a Novel Archaeal and Nanoarchaeal Assemblage 395 Thomas D. Niederberger, Elizabeth A. McCliment, and S. Craig Cary 39. Analysis of the Metagenome from a Biogas-Producing Microbial Community by Means of Bioinformatics Methods 403 Sebastian Jaenicke, Martha Zakrzewski, Sebastian J¨unemann, Alfred P¨uhler, Alexander Goesmann, and Andreas Schl¨uter 40. Amplicon Pyrosequencing Analysis of Endosymbiont Population Structure 415 Frank J. Stewart and Colleen M. Cavanaugh 41. Investigating Bacterial Diversity Along Alkaline Hot-Spring Thermal Gradients by Barcoded Pyrosequencing 423 Scott R. Miller and Michael Weltzer 42. Genetic Characterization of Microbial Communities Living at the Surface of Building Stones 429 Ma¨ıt´e Berdoulay and Jean-Claude Salvado Part 6 Biodegradation 43. Novel Aromatic Degradation Pathway Genes and their Organization as Revealed by Metagenomic Analysis 439 Kentaro Miyazaki 44. Functional Screening a Wide Host-Range Metagenomic Library from a Wastewater Treatment Plant Yields a Novel Alcohol/Aldehyde Dehydrogenase 451 Margaret Wexler, Philip L. Bond, David J. Richardson, and Andrew W. B. Johnston 45. Aromatic Hydrocarbon Degradation Genes from Chronically Polluted Subantarctic Marine Sediments 461 Hebe M. Dionisi, Mariana Lozada, Magal´ı S. Marcos, Walter D. Di Marzio, and Claudia L. Loviso 46. Isolation and Characterization of Alkane Hydroxylases from a Metagenomic Library of Pacific Deep-Sea Sediment 475 Fengping Wang, Meixiang Xu, and Xiang Xiao Part 7 Biocatalysts and Natural Products 47. Emerging Fields in Functional Metagenomics and Its Industrial Relevance: Overcoming Limitations and Redirecting the Search for Novel Biocatalysts 483 Mirjam Perner, Nele Ilmberger, Hans Ulrich K¨ohler, Jennifer Chow, and Wolfgang R. Streit 48. Carboxylesterases and Lipases from Metagenomes 499 Jennifer Chow, Ulrich Krauss, Karl-Erich Jaeger, and Wolfgang R. Streit 49. Expanding Small-Molecule Functional Metagenomics through Parallel Screening of Broad Host-Range Cosmid Environmental DNA Libraries in Diverse Proteobacteria 507 Jeffrey W. Craig and Sean F. Brady 50. Biomedicinals from the Microbial Metagenomes of Marine Invertebrates 517 Walter C. Dunlap, Paul F. Long, and Marcel Jaspars 51. Molecular Characterization of TEM-Type Beta-Lactamases Identified in Cold-Seep Sediments of Edison Seamount (South of Lihir Island, Papua New Guinea) 545 Sang Hee Lee and Jung-Hyun Lee 52. Identification of Novel Bioactive Compounds from the Metagenome of the Marine Sponge Haliclona simulans 553 David P. H. Lejon, Jonathan Kennedy, and Alan D. W. Dobson 53. Functional Viral Metagenomics and the Development of New Enzymes for DNA and RNA Amplification and Sequencing 563 Thomas W. Schoenfeld, Nick Hermersmann, Mike Moser, Darby Renneckar, Vinay Dhodda, and David Mead Part 8 Summary 54. Metagenomics: The Paths Forward 581 C. Titus Brown and James M. Tiedje 55. Darwin in the Twenty-First Century: Natural Selection, Molecular Biology, and Species Concepts 589 Francisco J. Ayala Index 597
£271.65
John Wiley and Sons Ltd Phloem
Book SynopsisPhloem: Molecular Cell Biology, Systemic Communication, Biotic Interactionsis a timely collection of research on the cellular and molecular biology of this plant vascular tissue. Recent advances in phloem research have revealed the centrality of this plant tissue to whole plant development and physiology. Building on advances made through developments of new analytical technologies, this book will provide readers with a current and comprehensive reference on the role of phloem in plant growth and development. Collecting the work of a global team of leading researchers,Phloem will provide the reader with a valuable synthesis of the latest research in a single volume.Table of ContentsContributors vii Section A Introduction 1 Chapter 1 Phloem, the Integrative Avenue 3 Aart J.E. van Bel and Gary A. Thompson Chapter 2 Cell Biology of Sieve Element–Companion Cell Complexes 8 Rosemary G. White Chapter 3 Fundamentals of Phloem Transport Physiology 30 John W. Patrick Section B Functional Aspects of Structural SE Components 61 Chapter 4 Roles of Plasma Membrane Transporters in Phloem Functions 63 Mechthild Tegeder, Yong-Ling Ruan, and John W. Patrick Chapter 5 Regulation of Sucrose Carrier Activities 102 Christina K¨uhn Chapter 6 Cellular Basis of Electrical Potential Waves along the Phloem and Impact of Coincident Ca2+ Fluxes 122 Jens B. Hafke and Aart J.E. van Bel Chapter 7 Sieve Element Occlusion 141 Michael Knoblauch and Daniel Mullendore Section C Long-Distance Signaling 155 Chapter 8 Sieve Elements: Puzzling Activities Deciphered through Proteomics Studies 157 Sylvie Dinant and William J. Lucas Chapter 9 Endogenous RNA Constituents of the Phloem and Their Possible Roles in Long-Distance Signaling 186 Julia Kehr and Anja Buhtz Chapter 10 The Effect of Long-Distance Signaling on Development 209 David J. Hannapel Chapter 11 Plant Defense and Long-Distance Signaling in the Phloem 227 Frank Gaupels and A. Corina Vlot Section D Biotic Interactions with the Phloem 249 Chapter 12 Role of Phloem Metabolites in Plant Defense 251 Jillian M. Hagel, Akpevwe Onoyovwi, Edward C. Yeung, and Peter J. Facchini Chapter 13 Viroids and Phloem-Limited Viruses: Unique Molecular Probes of Phloem Biology 271 Lucy R. Stewart, Biao Ding, and Bryce W. Falk Chapter 14 Phytoplasmas and Spiroplasmas: The Phytopathogenic Mollicutes of the Phloem 293 Allyson M. MacLean and Saskia A. Hogenhout Chapter 15 Breaching the Sieve Element—The Role of Saliva as the Molecular Interface between Aphids and the Phloem 310 Torsten Will, James C. Carolan, and Thomas L. Wilkinson Chapter 16 Behavioral and Molecular-Genetic Basis of Resistance against Phloem-Feeding Insects 328 Linda L. Walling and Gary A. Thompson Index 353 A color page section appears between pages 40 and 41
£181.40
John Wiley and Sons Ltd Molecular Markers in Plants
Book SynopsisMolecular Markers in Plants surveys an array of technologies used in the molecular analysis of plants. The role molecular markers play in plant improvement has grown significantly as DNA sequencing and high-throughput technologies have matured.Table of ContentsContributors ix Preface xiii 1 Evolution of DNA Marker Technology in Plants 3Robert J. Henry Introduction 4 Early Marker Technologies 4 Evolving Range of Applications of DNA Markers in Plants 12 Applications 13 Future Developments 15 References 15 2 Whole-Genome Sequencing for Marker Discovery 21Mark Edwards Sequencing Strategies 22 Sequencing Technologies 23 Epigenetic Markers 31 Genome-Wide Selection 32 Data Analysis Resources 32 References 33 Color plate section located between pages 34 and 35. 3 Amplicon Sequencing for Marker Discovery 35Timothy R. Sexton and Frances M. Shapter Introduction 36 Background 36 Maximizing Efficiency Through Sample Pooling 38 Limitations of Amplicon-Based MPS 44 Bioinformatics 51 Concluding Remarks 52 Acknowledgments 52 References 53 4 Transcriptome Sequencing for Marker Discovery 57Susan Gillies Introduction 58 Basic Approach 58 Conclusions 64 References 64 5 Molecular Markers in Plant Improvement 67Peter J. Prentis, Edward K. Gilding, Ana Pavasovic, Celine H. Frere, and Ian D. Godwin Introduction 68 Plant Domestication and Traditional Breeding 68 Application of Molecular Markers to Breeding 70 Next-Generation Approaches to QTL Discovery 75 Conclusion 77 References 78 6 Applications of Molecular Markers in Plant Conservation 81Maurizio Rossetto and Paul D. Rymer Introduction 82 Traditional Approaches 86 The Way Forward 91 Conclusion 95 References 96 7 Molecular Markers for Plant Biosecurity 99Andrew D.W. Geering Introduction 100 The Present—PCR for Specific Diagnosis and for DNA Barcoding 101 The Future—Next-Generation Sequencing Methods to Revolutionize Plant Quarantine Diagnostics 105 Conclusions 110 Acknowledgments 111 References 111 8 Molecular Markers for Harnessing Heterosis 119Gopala S. Krishnan, A.K. Singh, Daniel L.E.Waters, and Robert J. Henry Introduction 120 Molecular Markers for Understanding the Genetic Basis of Heterosis 122 Molecular Diversity and Heterosis—Molecular Markers for Predicting Heterosis 123 Conclusion 131 References 132 9 Genetic Variant Discovery and Its Use in Genome Characterization of Agronomically Important Crop Species 137Stephane Deschamps and Matthew A. Campbell Introduction 138 Sanger Resequencing 140 Single Feature Polymorphisms 140 Next-Generation Sequencing 143 High-Density Genotyping using the Illumina Golden Gate Platform 153 Genotyping by Sequencing 155 Genome Characterization and Haplotypes 157 Conclusions and Perspectives 159 References 160 10 Future Prospects of Molecular Markers in Plants 169Reyazul R. Mir and Rajeev K. Varshney Introduction 170 Molecular Markers: The Past 172 Molecular Markers: The Present 173 Molecular Markers: The Future 175 Novel Approaches or Platforms for Plant Breeding 180 Conclusions 183 Acknowledgments 184 References 184 Index 191
£181.40
John Wiley & Sons Inc Understanding Genetics A Molecular Approach
a huge range and FREE tracked UK delivery on ALL orders.
£104.45
Schiffer Publishing Ltd Hidden Beauty Exploring the Aesthetics of Medical
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£39.09
Sinauer Associates Is an Imprint of Oxford University Press Fundamentals of Molecular Evolution
Book SynopsisPublished by Sinauer Associates, an imprint of Oxford University Press. This book describes the dynamics of evolutionary change at the molecular level, the driving forces behind the evolutionary process, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes, the methodology involved in dealing with molecular data from an evolutionary perspective, and the logic of molecular hypothesis testing. The second edition incorporates newly acquired evolutionary insight from genome projects involving bacteria, plants, and animals, as well as analytical tools that have been developed and perfected in the last decade, and has been brought up to date in line with the many advances in genomics, protein engineering, computational biology, and bioinformatics.The authors explain evolutionary phenomena at the molecular level in a way that can be understood without much prerequisite knowledge of molecular biology, evolution, or mathematics. Both mathematical and intuitive explanations are provided, and examples that support and clarify the many theoretical arguments and methodological discussions are included.Trade ReviewFundamentals Of Molecular Evolution can serve both as an excellent text book for students of different biological disciplines and as a very useful introduction into molecular evolution for professional readers. Undoubtedly, this book should be an essential purchase for all libraries in higher education institutions with biology departments. * V. N. Ksenzenko and Y. A. Trotsenko, Journal of Chemical Technology and Biotechnology *Table of ContentsIntroduction.- Genes, Genetic Codes, and Mutation.- Dynamics of Genes in Populations.- Evolutionary Change in Nucleotide Sequences.- Rates and Patterns of Nucleotide Substitution.- Molecular Phylogenetics.- Gene Duplication, Exon Shuffling, and Concerted Evolution.- Evolution by Transposition.- Genome Evolution.- Appendix I. Timetables of Evolution.- Appendix II. Basics of Probability.- Literature Cited.- Subject Index.- Appendix I: Spatial and Temporal Frameworks of the Evolutionary Process.- Appendix II: Basics of Probability.- Literature Cited.- Index.- Taxonomic Index.
£135.99
John Wiley and Sons Ltd Amino Acids and Proteins in Fossil Biominerals
Book SynopsisTable of ContentsPreface vii Acknowledgements ix 1 Biominerals and the Fossil Record 1 Why Study Old Biominerals? 1 What are Biominerals? 4 How and Why are Biominerals Formed? 5 ‘Biomineralization Toolkit’: From Proteins to Proteomes 8 Fossil Biominerals, Fossil Proteomes 12 References 16 2 Mechanisms of Degradation and Survival 23 Introduction 23 Hydrolysis 27 Racemization 31 Decomposition and Other Diagenesis-induced Modifications 35 References 38 3 Proteins in Fossil Biominerals 43 Bone and Other Collagen-based Hard Tissues 43 Tooth 45 Eggshell 47 Mollusc Shell 51 Other Substrates 57 References 63 4 Chiral Amino Acids: Geochronology and Other Applications 71 Dating the Quaternary (Pleistocene and Holocene) 71 Principles of AAR Dating 76 Measuring D/L Values 78 Factors Affecting D/L Values 82 Aminostratigraphy 87 Aminochronology 92 Palaeothermometry 97 Testing the Suitability of Biominerals for Geochemical Analyses 98 Taxonomic Identification 99 Appendix: Practical Tips on How to Plan and Conduct an AAR Study 100 References 104 5 Ancient Protein Sequences 113 Ancient Protein Analysis by Mass Spectrometry 113 Ancient Proteins: Past and Future 120 References 122 Index 127
£79.95
John Wiley and Sons Ltd Zika Virus and Diseases
Book SynopsisCompiles the most current information on the Zika virus and its associated diseases This comprehensive book provides the most up-to-date information for students, medical students, and scientists on Zika virus and its associated diseases. It includes all the information related to the Zika virus since its discovery in 1947; its epidemic outbreak in 2007-2014; how the epidemiology changed in America in 2015-2016; its mode of transmission; how to prevent and treat it; and associated diseases. Zika Virus and Diseases: From Molecular Biology to Epidemiology offers complete and up-to-date coverage in 10 chapters. It presents information from papers that attempted to associate the virus with diseases in Africa until the first animal experiment; discusses its association with Guillain-Barré syndrome and microcephaly; describes the basic mechanisms for Zika (ZIKV) replication, including important differences between Dengue (DENV), West-Nile virus (WNV), and ZIKV;Table of ContentsPreface ix List of Abbreviations xi 1 The History of ZIKV Discovery 1 1.1 ZIKV Isolation from Monkeys and Mosquitos 1 1.2 ZIKV Infection in Humans 6 1.3 ZIKV Infection Spread to Other Hosts and Regions 7 1.4 Cross‐Paths between ZIKV and Other Flaviviruses 9 References 10 2 ZIKV: From Silent to Epidemic 15 2.1 Outbreak in Yap Island (2007) 15 2.2 Outbreak in French Polynesia (2013) 16 2.3 How Did ZIKV Reach Brazil? 18 2.4 Outbreak in Brazil (2015) 18 2.5 ZIKV Spread through South, Central, and North Americas 20 References 22 3 ZIKV Transmission and Prevention 29 3.1 Modes of Transmission 29 3.2 Prevention 37 References 40 4 Association with Guillain‐Barre Syndrome and Microcephaly 49 4.1 Association with Neurological Disorders 49 References 58 5 ZIKV Animal Models 69 5.1 Animal Models: Embryonated Hen Eggs 69 5.2 Animal Models: Landrace Piglet 69 5.3 Animal Models: Mice 70 5.4 Animal Model: Nonhuman Primate 74 References 78 6 Biology of ZIKV 83 6.1 Structural and Physical Properties of ZIKV Virion 84 6.2 Binding and Entry 87 6.3 Genome Structure 89 6.4 Translation and Proteolytic Processing 91 6.5 Features of the Nonstructural Proteins 92 6.6 RNA Replication 100 6.7 Features of the Structural Proteins 104 6.8 Virus Assembly and Release from Virus‐Infected Cells 107 References 109 7 Zika Virus (ZIKV) Strains and Lineages 131 7.1 East and West African Lineage 131 7.2 Africa vs. Asian/American Lineage 132 References 140 8 ZIKV‐Host Interactions 147 8.1 Systematic Studies to Identify ZIKV Affected Functions and Pathways 147 8.2 Induction and Dysregulation of Innate Immune Responses during ZIKV Infection 150 8.3 Induction of Cell Death and Apoptosis by ZIKV 156 8.4 Induction of Autophagy by ZIKV 160 8.5 Dysregulation of Cell Cycle and Induction of Abnormal Mitosis by ZIKV 163 References 164 9 Inhibitors of ZIKV Replication and Infection 179 9.1 Drugs That Lead to the Destruction of ZIKV Virions 179 9.2 Drugs That Inhibit ZIKV Entry and Endocytosis 180 9.3 Drugs That Target ZIKV NS2B‐NS3 Protease Activity 186 9.4 Drugs That Target ZIKV NS5 RNA‐Dependent RNA Polymerase Activity 191 9.5 Neutralizing Antibodies That Target ZIKV Structural Protein 200 9.6 Drugs That Inhibit ZIKV Infection by Targeting Host Machinery 201 9.7 Drugs That Show Neuroprotective Activity but Do Not Suppress ZIKV Replication: Emricasan 205 9.8 Other Drugs That Inhibit ZIKV Infection Identified from a Screening of FDA‐Approved Drugs 206 References 210 10 Long‐Term Care and Perspectives 229 10.1 Prenatal Care and Diagnosis of Abnormal Fetus Development 229 10.2 Long‐Term Care for Patients Affected by ZIKV 230 10.3 Assistance to Families with Children Affected by ZIKV 230 10.4 Perspectives 231 References 232 Index 237
£103.50
OM Book Service Loose Leaf for Concepts of Genetics
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£136.60
McGraw-Hill Companies Loose Leaf for Genetics Analysis and Principles
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£140.40
WW Norton & Co Dark and Magical Places The Neuroscience of
Book SynopsisHow the brain helps us to understand and navigate space—and why, sometimes, it doesn’t work the way it should.Trade Review"Christopher Kemp may not be able to find his way out of a stairwell, but he has quickly and with no false turns made his way to the top of my list of favorite science writers. For all his navigational shortcomings, Kemp is an expert guide to the most complex landscape of all: the human brain. He’s a natural storyteller, a deft explainer, and a terrific and funny writer." -- Mary Roach, author of Fuzz"Christopher Kemp’s brilliant and beguiling new book reveals that behind the curtain of the seemingly quotidian act of traversing space lies an array of intricate neuroscientific magic tricks, temporal feats of strength, hiccups, and elusive mysteries. Like the brain itself, Kemp’s wild writing quakes and sparks, uncovering the lyric lurking in the neuroscientific, the hilarious in the incantatory." -- Matthew Gavin Frank, author of Flight of the Diamond Smugglers"A dazzling—at times dizzying—exploration of brains and places, how they trouble one another and how they give one another meaning." -- Robert Moor, author of On Trails"A fascinating and sneakily amusing book. Kemp is an elegant and quick-witted writer who, feeling perpetually and hopelessly lost himself, is perfectly qualified to lead us through some of the most complicated and discombobulating corners of human cognition." -- John Mooallem, author of Wild Ones and This Is Chance!"A modern look inside the brain, written as beautifully as a long-form poem. Don’t miss this opportunity to let Kemp show you the how and why of where." -- David Eagleman, Stanford neuroscientist, author of Incognito and Livewired"As both scientist and scribe, Kemp brings his gifts of curiosity and intelligence to bear on the topic of navigation and shows us that there is no shame in being lost. On the contrary, Kemp demonstrates that to be continuously and authentically in search of our place on Earth is a wondrous thing." -- M. R. O’Connor, author of Wayfinding"Finding our way is a basic necessity of life, yet it is mostly taken for granted. Kemp effectively explains just how complex and astonishing that task really is." -- Tony Miksanek - Booklist"An intense lesson in the neuroscience of getting around." -- Kirkus"This tome is no textbook. It is designed to be accessible to a large audience: Nonscientists will benefit from Kemp’s capacity to render vivid representations of the complexity of living organisms, but scientists, too, are likely to gain something from reading this book." -- Marcia Bécu and Christian F. Doeller - Science"Kemp debunks numerous myths, including the idea that females possess poorer navigational skills than males, and reflects on the difference between the navigational abilities of modern humans versus those of Neanderthals. What separates the two, he suggests, is the use of the subjunctive form, which led to humans being better at navigating. Kemp peppers in accounts of his own poor navigational abilities and colorful stories of people getting lost, which keep things moving along. The result is both enjoyable and accessible." -- Publishers Weekly
£14.39
Basic Books Life as We Made It: How 50,000 Years of Human
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£22.50
American Society for Microbiology Principles of Microbial Diversity
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£85.44
American Society for Microbiology Medical Biotechnology
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£85.50
American Society for Microbiology Antibodies for Infectious Diseases
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£102.60
American Society for Microbiology Molecular Microbiology: Diagnostic Principles and
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£151.00
American Society for Microbiology Paleomicrobiology of Humans
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£65.08
American Society for Microbiology Mobile DNA III
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£121.00
American Society for Microbiology Virulence Mechanisms of Bacterial Pathogens
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£108.90
Oxford University Press Inc The Cell: A Molecular Approach
Book SynopsisEven the most experienced instructor can find teaching cell biology daunting, and most cell biology texts are bogged down in detail or background information. Lost in all the details are the more fascinating material and contemporary advances that represent this rapidly moving field. With so much to cover, creating a classroom around active learning may be difficult or nearly impossible. The Cell: A Molecular Approach, Eighth Edition, endeavors to address those issues with succinct writing, incorporation of current research, a test bank that encourages critical thinking, and an active learning framework. With just enough detail for a one-semester, sophomore/junior level course, the text presents fundamental concepts and current research, including chapters on Genomics and Transcriptional Regulation and Epigenetics, and new in-text boxed features on Molecular Medicine and Key Experiments. Instructors will appreciate updates to the eighth edition test bank, such as raising the Bloom's level of questions overall, and giving instructors the ability to select questions based on level. Finally, for instructors who want to flip their classrooms or just get students more engaged, The Cell, Eighth Edition, is the only cell biology text that is accompanied by an Active Learning Guide. This chapter-by-chapter playbook shows instructors how to create a dynamic learning environment with in-class exercises, clicker questions, and links to relevant media, animations, testing, and self-quizzing, all aligned with the new in-text learning objectives, wherever appropriate. This text provides the right level of detail, student engagement, and instructor support for the modern cell biology classroom.Trade Review"I like the level of detail, modularity, resources and questions, and supplementary materials. I think the students like the clarity that the book provides. It is taught on a good level for undergraduates, especially those interested in medicine (teaching to the level of detail in the MCATs is always a good idea in my course)." -Nathan Jebbett, University of Vermont "I have not been able to find any other textbook that provides the key essential information related to this complex scientific area with the simplicity and depth provided in this textbook." -Germán Rosas-Acosta, The University of Texas at El Paso "This textbook is not too advanced for the medical students. Other textbooks (such as The Cell by Alberts) are more appropriate for PhD-level students with more details, but The Cell is a good, solid textbook for students in healthcare professions, with the 'right' amount of details." -Nancy Bae, Midwestern University "A formidable text on the molecular aspects of biology, biochemistry, cell function and regulation." -Floyd C. Knoop, Creighton UniversityTable of ContentsPart I: Fundamentals and FoundationsChapter 1. Introduction to Cells and Cell ResearchChapter 2. Molecules and MembranesChapter 3. Bioenergetics and MetabolismChapter 4. Fundamentals of Molecular BiologyChapter 5. Genomics, Proteomics, and Systems BiologyPart II: The Flow of Genetic InformationChapter 6. Genes and GenomesChapter 7. Replication, Maintenance, and Rearrangements of Genomic DNAChapter 8. RNA Synthesis and ProcessingChapter 9. Transcriptional Regulation and EpigeneticsChapter 10. Protein Synthesis, Processing, and RegulationPart III: Cell Structure and FunctionChapter 11. The NucleusChapter 12. Protein Sorting and TransportChapter 13. Mitochondria, Chloroplasts, and PeroxisomesChapter 14. The Cytoskeleton and Cell MovementChapter 15. The Plasma MembraneChapter 16. Cell Walls, the Extracellular Matrix, and Cell InteractionsPart IV: Cell RegulationChapter 17. Cell SignalingChapter 18. The Cell CycleChapter 19. Cell Renewal and Cell DeathChapter 20. Cancer
£181.58
Cold Spring Harbor Laboratory Press,U.S. Restriction Enzymes: A History
Book Synopsis
£49.18
American Society for Microbiology The Power of Plagues
Book Synopsis
£31.30
