Metabolism Books
HarperCollins Publishers Good Energy
Book SynopsisTHE NUMBER ONE NEW YORK TIMES BESTSELLER''The best deep dive into the diseases that plague us all today, and what to do to heal.'' Jessie Inchauspe, The Glucose Goddess''A powerful vision for a brighter future for both people and the planet.'' Jay Shetty''A tour de force'' Dr Mark HymanFix your metabolism to feel better today and prevent disease tomorrow. A bold new vision for optimizing our health now and for the future.What if depression, anxiety, infertility, insomnia, heart disease, type 2 diabetes, Alzheimer's, dementia, cancer and many other health conditions actually have the same root cause?Our ability to prevent and reverse these conditions and feel incredible today is under our control and simpler than we think. The key is our metabolic function the most important and least understood factor in our overall health. As Dr Casey Means explains in this groundbreaking book, nearly every health problem we face can be explained by how well the cells in our body create and use en
£17.00
HarperCollins Publishers 5 Appetites Eat Like the Animals for a Naturally
Book SynopsisA New Scientist Best Book of 2020How is it that a baboon and a blob of slime mould instinctively know what to eat for optimal health, balancing their protein, fat and carb intake in perfect proportions?In new, groundbreaking research that is transforming our understanding of nutrition, animals from locusts to lions and yes, humans too, demonstrate the remarkable science behind appetite.Appetite communicates the body''s nutritional needs to the brain, and eating in accordance with your body''s demands, like the animals, should ensure optimal health, but the modern fast food world wreaks havoc on this evolutionarily honed system.In several landmark studies, Raubenheimer and Simpson prove that appetite can be hacked we can eat for optimal health, for increased fertility or for a longer lifespan. Understanding the science of the appetite offers tremendous power in shaping our bodies and controlling our lives.** Previously published as Eat Like the Animals **Trade ReviewPraise for The Five Appetites‘Raubenheimer and Simpson are known for their deep knowledge of biology and its application to areas of nutrition that are of exceptional interest these days: evolution, feeding behavior, proteins, and insects. These, they weave together into a compelling narrative that should fascinate readers concerned about the science of what we eat as well as the influence of our food environment on our biology.’ Marion Nestle, author of What to Eat Praise for David Raubenheimer and Stephen J. Simpson‘This outstanding book provides the first comprehensive theoretical framework for analyzing the roles of nutrition across a huge swath of fields, from ecology and evolution to conservation and human health. The Nature of Nutrition is creative and scholarly yet approachable. I know of no other book like it.’ Bernard J. Crespi, Simon Fraser University ‘Strikingly well-written … The clear language and enlightening examples allow for the educated layman interested in biology to be astonished by the enormous implications of the nature of nutrition.’ American Journal of Human Biology ‘A really good read.’ Bulletin of the British Ecological Society
£9.99
John Wiley and Sons Ltd Metabolism at a Glance
Book SynopsisMetabolism at a Glance presents a concise, illustrated summary of metabolism in health and disease. This essential text is progressively appropriate for introductory through to advanced medical and biochemistry courses.Table of ContentsPreface ix Acknowledgements x Part 1 Energy metabolism 1 Introduction to metabolic pathways 2 2 Biosynthesis of ATP I: ATP, the molecule that powers metabolism 4 3 Biosynthesis of ATP II: mitochondrial respiratory chain 6 4 Oxidation of cytosolic NADH: the malate/aspartate shuttle and glycerol phosphate shuttle 8 5 Metabolism of glucose to provide energy 10 6 Metabolism of one molecule of glucose yields 31 (or should it be 38?) molecules of ATP 12 7 Anaerobic metabolism of glucose and glycogen to yield energy as ATP 14 8 2,3‐Bisphosphoglycerate (2,3‐BPG) and the red blood cell 16 9 Metabolism of triacylglycerol to provide energy as ATP 18 Part 2 Carbohydrate metabolism 10 Metabolism of glucose to glycogen 20 11 Glycogen metabolism I 22 12 Glycogen metabolism II 24 13 Glycogen metabolism III: regulation of glycogen breakdown (glycogenolysis) 26 14 Glycogen metabolism IV: regulation of glycogen synthesis (glycogenesis) 28 15 Pentose phosphate pathway: the production of NADPH and reduced glutathione 30 16 Regulation of glycolysis: overview exemplified by glycolysis in cardiac muscle 32 17 Glycolysis in skeletal muscle: biochemistry of sport and exercise 34 18 Regulation of gluconeogenesis 36 19 Regulation of Krebs cycle 38 20 Mammals cannot synthesize glucose from fatty acids 40 21 Supermouse: overexpression of cytosolic PEPCK in skeletal muscle causes super‐athletic performance 42 22 Sorbitol, galactitol, glucuronate and xylitol 44 23 Fructose metabolism 46 24 Ethanol metabolism 48 Part 3 Fat metabolism 25 Pyruvate/malate cycle and the production of NADPH 50 26 Metabolism of glucose to fat (triacylglycerol) 52 27 Metabolism of glucose to fatty acids and triacylglycerol 54 28 Glycolysis and the pentose phosphate pathway collaborate in liver to make fat 56 29 Esterification of fatty acids to triacylglycerol in liver and white adipose tissue 58 30 Mobilization of fatty acids from adipose tissue I: regulation of lipolysis 60 31 Mobilization of fatty acids from adipose tissue II: triacylglycerol/fatty acid cycle 62 32 Glyceroneogenesis 64 33 Metabolism of protein to fat after feeding 66 34 Elongation and desaturation of fatty acids 68 35 Fatty acid oxidation and the carnitine shuttle 70 36 Ketone bodies 72 37 Ketone body utilization 74 38 β-Oxidation of unsaturated fatty acids 76 39 Peroxisomal β‐oxidation 78 40 α‐ and β‐oxidation 80 41 ω-Oxidation 82 Part 4 Steroid metabolism 42 Cholesterol 84 43 Steroid hormones and bile salts 86 Part 5 Amino acid metabolism 44 Biosynthesis of the non‐essential amino acids 88 45 Catabolism of amino acids I 90 46 Catabolism of Amino Acids II 92 47 Metabolism of amino acids to glucose in starvation and during the period immediately after refeeding 94 48 Disorders of amino acid metabolism 96 49 Phenylalanine and tyrosine metabolism 98 50 Tryptophan metabolism: the biosynthesis of NAD + , serotonin and melatonin 100 51 Ornithine cycle for the production of urea: the ‘urea cycle’ 102 Part 6 Metabolic channelling 52 Metabolic channelling I: enzymes are organized to enable channelling of metabolic intermediates 104 53 Metabolic channelling II: fatty acid synthase 106 Part 7 Purines, pyrimidines and porphyrins 54 Amino acid metabolism, folate metabolism and the ‘1‐carbon pool’ I: purine biosynthesis 108 55 Amino acid metabolism, folate metabolism and the ‘1‐carbon pool’ II: pyrimidine biosynthesis 110 56 Krebs uric acid cycle for the disposal of nitrogenous waste 112 57 Porphyrin metabolism, haem and the bile pigments 114 Part 8 Integration of metabolic pathways and diabetes 58 Metabolic pathways in fasting liver and their disorder in Reye’s syndrome 116 59 Diabetes I: metabolic changes in diabetes 118 60 Diabetes II: types I and II diabetes, MODY and pancreatic β‐cell metabolism 120 61 Diabetes III: type 2 diabetes and dysfunctional liver metabolism 122 Index 125
£34.15
Oxford University Press Enzymes
Book SynopsisEnzymes are the astonishing, tiny molecular machines that make life possible. Each one of these small proteins speeds up a single chemical reaction inside a living organism many millionfold. Working together, teams of enzymes carry out all the processes that collectively we recognise as life, from making DNA to digesting food. This Very Short Introduction explains the why and the how of speeding up these reactions - catalysis - before going on to reveal how we have evolved these catalysts of such extraordinary power and exquisite selectivity. Paul Engel shows how X-ray crystallography has revealed the complex molecular shapes that allow enzymes to function at an extraordinarily sophisticated level. He also examines medical aspects of enzymes, both in the way faulty enzymes cause disease and in the way enzymes can be used for diagnosis and therapy. Finally, he looks at the many varied ways in which individual enzymes, taken out of their biological context, are used nowadays as tools - in washing powders, food production, waste treatment, and chemical synthesis.ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.Trade ReviewA fairly comprehensive textbook that provides a decent technical grounding in enzymology and will no doubt teach many professional biologists a thing or two * Nadia Abbott AMRSB, The Biologist *This book would be an excellent accompaniment to an undergraduate biology student or someone with a scientific background who wishes to know more about enzymology. * Lucy Elphick, The Biochemist *It would be perfect for students who want to have a (somewhat more than) basic understanding of the subject before delving deeper ... my overall understanding of the subject is more rounded. Thanks Professor Engel! * Mary Staunton, University College Dublin Today *Table of Contents1: No Enzymes, No Life 2: Making Things Happen - Catalysis 3: The Chemical Nature of Enzymes 4: Structure for Catalysis 5: Enzymes in Action 6: Metabolic Pathways and Enzyme Evolution 7: Enzymes and Disease 8: Enzymes as Tools 9: Enzymes and Genes - New Horizons References Further reading Index
£9.49
Elsevier - Health Sciences Division Adrenal Disorders
Book SynopsisTrade Review"This book provides practical guidance and clinical insight for the assessment and management of a wide variety of adrenal disorders using cased-based learning. It is a helpful resource for practitioners and trainees alike, especially for reviewing rarely seen cases with expert advice." ©Doody's Review Service, 2022, Marcelo Ramirez, M.D. (Cook County Health)Table of ContentsSection A. Incidentally Discovered Adrenal Mass Case #1: 45-Year Old Woman with an Incidentally Discovered Large Adrenal Mass Case #2: Adrenal Mass in a Patient with History of Extra-adrenal Malignancy: the Role of Imaging Case #3: Incidentally Discovered Adrenal Mass in a Patient with History of Extra-adrenal Malignancy: the Role of Adrenal Biopsy Case #4: Nonfunctioning Lipid Rich Adrenocortical Adenoma-Role of Follow-up Case #5: 54-Year Old Woman with an Incidentally Discovered Adrenal Mass and Abnormal Dexamethasone Suppression Test: Role of Adrenalectomy Case #6: Lipid Poor Adrenal Masses-The Case for Aggressive Management Section B. Primary Aldosteronism Case #7: Primary Aldosteronism-When Adrenal Venous Sampling is not Needed Before Unilateral Adrenalectomy Case #8: Primary Aldosteronism with Unilateral Adrenal Nodule on Computed Tomography Case #9: Primary Aldosteronism with Bilateral Adrenal Nodules on Computed Tomography Case #10: Primary Aldosteronism Caused by Unilateral Adrenal Hyperplasia Case #11: Primary Aldosteronism in a Patient with Bilateral Macronodular Adrenal Hyperplasia and Associated Clinically Important Cortisol Co-secretion Case #12: Primary Aldosteronism in a Patient with an Adrenal Macroadenoma and Clinically Important Cortisol Co-secretion Case #13: Primary Aldosteronism in a Patient Treated with Spironolactone Case #14: Failed Catheterization of the Right Adrenal Vein-When Incomplete Adrenal Venous Sampling Data Can Be Used to Direct a Surgical Cure Case #15: Primary Aldosteronism: When Adrenal Venous Sampling Shows Suppressed Aldosterone Secretion From Both Adrenal Glands Section C. ACTH-Independent Cushing Syndrome Case #16: 28-Year-Old Woman with Remote History of Adrenal Mass Presenting with New Onset Hypertension and Weight Gain Case #17: 26-Year-Old Woman with a Discrepant Work-up for Cushing Syndrome Subtype Case #18: 45-Year-Old Woman with Corticotropin-Independent Cushing Syndrome and Bilateral Adrenal Adenomas Case #19: Corticotropin-Independent Cushing Syndrome in a Patient with "Normal Adrenal Imaging Case #20: 66-Year-Old Woman with Corticotropin-Independent Hypercortisolism and Bilateral Macronodular Adrenal Hyperplasia Case #21: 35-Year-Old Woman with Low Bone Density and Fractures Case #22: Carney Triad (Pentad) and Adrenal Adenoma with Clinically Important Cortisol Secretory Autonomy Section D. Adrenal Cortical Carcinoma and Oncocytic Neoplasm Case #23: Adrenal cortical carcinoma in a patient with history of adrenal incidentaloma Case #24: Unexpected Diagnosis of Adrenal Cortical Carcinoma: Role of Urinary Steroid Profiling Case #25: Oncocytic adrenocortical carcinoma Case #26: Mitotane therapy in the ENSAT Stage II Adrenocortical Carcinoma Case #27: Cortisol-Secreting Metastatic Adrenocortical Carcinoma-Role for Surgical Debulking of the Primary Tumor Case #28: Adrenocortical Carcinoma and Severe Cushing Syndrome Case #29: Pure Aldosterone-Secreting Adrenocortical Carcinoma Case #30: Long-standing Primary Aldosteronism in a Patient Diagnosed with Metastatic Adrenocortical Carcinoma Case #31: Adrenocortical Carcinoma Associated with Lynch Syndrome Case #32: Adrenocortical Carcinoma Associated with Multiple Endocrine Neoplasia Type 1 Case #33: Adrenocortical Carcinoma Presenting with Inferior Vena Cava Thrombus Case #34: Management of Mitotane Therapy in Adrenocortical Carcinoma Section E. Pheochromocytoma and Paraganglioma Case #35: Most Pheochromocytomas Grow Slowly Case #36: The "Prebiochemical Pheochromocytoma Case #37: Huge Catecholamine-Secreting Tumor Case#38: Metyrosine Use in a Patient with Metastatic Pheochromocytoma Case #39: Pheochromocytoma in a Patient with Neurofibromatosis Type 1 Case #40: New Diagnosis of Multiple Endocrine Neoplasia Type 2A in a Patient with Bilateral Pheochromocytomas Case #41: Pheochromocytoma in a Patient with von Hippel Lindau Disease Case #42: Bilateral Pheochromocytoma in a Patient with MYC-associated Protein X (MAX) Genetic Predisposition Case #43: The Cystic Pheochromocytoma Case #44: Skull Base and Neck Paragangliomas-Considerations for the Endocrinologist Case #45: Cardiac Paraganglioma. Case #46: Pheochromocytoma in Multiple Endocrine Neoplasia Type 2B Case #47: Metastatic Paraganglioma-An Approach to Management and the Use Serial Imaging to Assess Rate of Tumor Progression Case #48: Metastatic Pheochromocytoma-Role for 68-Ga DOTATATE PET CT Case #49: Carney Triad (Pentad) and Catecholamine-Secreting Paragangliomas Case #50: Metastatic Paraganglioma-Role For Systemic Chemotherapy Case #51: Cryoablation Therapy for Metastatic Paraganglioma Case #52: Paraganglioma in a patient with cyanotic cardiac disease Case #53: Metastatic Paraganglioma-Role For External Beam Radiation Therapy Section F. Corticotropin (ACTH)-Dependent Hypercortisolism Case #54:ACTH-Dependent Cushing Syndrome can be frequently misdiagnosed Case #55: ACTH-Dependent Cushing Syndrome-Role for Inferior Petrosal Sinus Sampling Case #56: ACTH-Dependent Cushing Syndrome-When Inferior Petrosal Sinus Sampling is Not Needed Case #57: Severe ACTH-Dependent Cushing Syndrome Due to a Pituitary Adenoma Ectopic Cushing Syndrome Associated with Multiple Endocrine Neoplasia Type 2B Case #59: Ectopic Cushing Syndrome Treated with Cryoablation Case #60: Cyclical Ectopic Cushing Syndrome Case #61: Mild Cushing Syndrome Associated with Ectopic Corticotropin Secretion Case #62: Bilateral Adrenal Cryoablation in Corticotropin-dependent Cushing Syndrome Case #63: Cushing Syndrome Associated with Ectopic Corticotropin and Corticotropin Releasing Hormone Secreting Pheochromocytoma Case #64: Cushing Syndrome in the Setting of Multiple Endocrine Neoplasia Type 1 Section G. Other Adrenal Masses Case #65: Adrenal Myelolipoma-A Computed Tomography Diagnosis Case #66: Adrenal Schwannoma Case #67: Trauma-Related Unilateral Adrenal Hemorrhage Case #68: Bilateral Adrenal Hemorrhage Case #69: Primary Adrenal Teratoma Case #70: The Adrenal Stone Case #71: Simple Adrenal Cyst Case #72: Adrenal Cystic Lymphangioma Case #73: Adrenal Hemangioma Case #74: Adrenal Ganglioneuroma Case #75: 42-Year-Old Woman with a Large Adrenal Mass Case #76: Primary Adrenal Leiomyosarcoma Case #77: Primary Adrenal Lymphoma Case #78. 39-Year-Old Man with a Large Adrenal Mass Case # 79: 59-Year-Old Man with Enlarging Bilateral Adrenal Masses Case # 80: 65-Year-Old Man with Primary Adrenal Insufficiency Case #81: 47-Year-Old Man with Primary Adrenal Insufficiency Case #82: Bilateral Adrenal Myelolipoma-Think of Congenital Adrenal Hyperplasia Case #83: A Unilateral Lipid Poor Adrenal Mass-An Atypical Presentation of Adrenal Histoplasmosis Case #84: Bilateral Macronodular Adrenal Hyperplasia (BMAH) in the Setting of Multiple Endocrine Neoplasia Type 1 Case #85: Pseudo-Adrenal Masses Section H. Adrenal and Ovarian Hyperandrogenism Case #86: A Huge Adrenal Myelolipoma in a Patient with a Suboptimally Controlled Congenital Adrenal Hyperplasia Case #87: Balancing Glucocorticoid and Androgen Excess in Congenital Adrenal Hyperplasia Case #88: Dehydroepiandrosterone-sulfate (DHEA-S): The "Love it or "Hate it Hormone Case #89: Sorting out the Source of Androgen Excess in a Postmenopausal Woman with an Adrenal and an Ovarian Mass Case #90: Primary Testosterone-Secreting Adrenocortical Carcinoma in a Premenopausal Woman. Case #91: Premenopausal Woman with Testosterone-secreting Ovarian Tumor Case #92: Sorting out the Source of Androgen Excess in a Postmenopausal Woman with an Adrenal Mass Case #93: Testosterone-Secreting Benign Adrenal Adenoma in a Postmenopausal Woman Section I. Adrenal Disorders in Pregnancy Case #94: Malignant Pheochromocytoma in Pregnancy Case #95: Catecholamine-Secreting Paraganglioma in Pregnancy Case #96: The Peripartum Diagnosis of Pheochromocytoma and a Genetic Mystery Solved Case #97. History of Pregnancy in a 41-Year-Old Woman with Undiagnosed Cushing syndrome Case #98: Pregnancy in a Patient with Primary Adrenal Insufficiency Case #99: Pregnancy in a Patient with 21-Hydroxylase Deficiency Case #100: Primary Aldosteronism in Pregnancy
£92.69
Taylor & Francis Ltd Atlas of Clinical Endocrinology and Metabolism
Book SynopsisThis updated text is a pictorial atlas of endocrine and metabolic disorders. Each chapter focuses on providing multiple illustrations as well as a thorough discussion of the diagnosis and management of a variety of endocrine diseases with their appropriate treatment plans. Using updated guidelines, it provides a comprehensive discussion of the latest therapies, including diabetes technology. Presenting a large number of clinical images, including imaging of thyroid ultrasounds, DXA images, bone scans, and new technologies in diabetes mellitus, this atlas aims to provide the reader with the information needed to make accurate diagnoses, making it an updated source of highly illustrated information for endocrinologists, clinicians, residents, fellows and trainees. With new chapters on transgender medicine and obesity, this textbook is a valuable resource for the contemporary endocrine practitioner.Features new chapters such as transgender medicine and inborn errors of metaTable of Contents1. Thyroid Disorders. 2. Diabetes Mellitus. 3. Obesity. 4. Metabolic Bone Disorders. 5. Hypothalamic-pituitary Disorders. 6. Adrenal Disorders. 7. Female Reproductive Disorders. 8. Male Reproductive Disorders. 9. Lipid Disorders. 10. Errors of Inborn Metabolism. 11. Neuroendocrine Tumors. 12. Endocrinologic Care of Transgender Patients. 13. Genetic Endocrine Disorders.
£137.75
John Wiley and Sons Ltd Textbook of Diabetes
Book SynopsisTextbook of Diabetes Classic textbook providing diabetologists and endocrinologists with illustrated and clinically focused content on diabetes Now in its sixth edition, the Textbook of Diabetes has established itself as the modern, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the textbook hosts an unrivalled blend of clinical and scientific content. Written by highly experienced editors and international contributors all of whom have provided insight on new developments in diabetes care. These include the most recent guidelines from the European Association for the Study of Diabetes (EASD), the American Diabetes Association (ADA), Diabetes UK, and the National Institute for Health and Care Excellence (NICE) and information on the latest treatment modalities used around the world. The textbook includes free access to the Wiley Digital Edition which provides easy-to-use searching across the book, the full reference list with web links, illustrations and photographs, and post-publication updates. Sample topics covered in Textbook of Diabetes include: Diabetes in its historical and social context, covering the history of diabetes, past classification and diagnosis of diabetes and the global burden of diabetes Normal physiology, covering glucose homeostasis, islet function and insulin secretion, and glucagon in islet and metabolic regulation Pathogenesis of diabetes, covering genetics of diabetes and obesity, autoimmune type 1 diabetes and other disorders with type 1 diabetes phenotype Other types of diabetes, covering endocrine disorders that cause diabetes, pancreatic diseases and diabetes and drug-induced diabetes Beautifully illustrated with a clinical focus, Textbook of Diabetes provides endocrinologists and diabetologists, both consultants/specialists and those in training, with a fresh and comprehensive clinical resource to consult time and time again. The text is also of value to specialist diabetes nurses and researchers in the field.Table of ContentsList of Contributors, viii Preface, xv List of Abbreviations, xvi Part 1 Diabetes in its Historical and Social Context 1 The History of Diabetes Mellitus, 3Robert B. Tattersall and David R. Matthews 2 Classification and Diagnosis of Diabetes, 22Ambady Ramachandran, Chamukuttan Snehalatha, Arun Raghavan, and Arun Nanditha 3 The Global Burden of Diabetes, 28Jessica L. Harding, Mary Beth Weber, and Jonathan E. Shaw 4 Epidemiology of Type 1 Diabetes, 41Lars C. Stene and Jaakko Tuomilehto 5 Epidemiology of Type 2 Diabetes, 55Ronald C.W. Ma and Peter C.Y. Tong Part 2 Normal Physiology 6 Overview of Glucose Metabolism, 77Richard I.G. Holt 7 Islet Function and Insulin Secretion, 84Peter M. Jones and Shanta J. Persaud 8 Glucagon in Islet and Metabolic Regulation, 99Jonathan E. Campbell and David A. D'Alessio 9 Mechanism of Insulin Action, 111Morris F. White 10 Central Control of Glucose Homeostasis, 128Kimberly M. Alonge, Kendra L. Francis, Nicole E. Richardson, and Michael W. Schwartz 11 Control of Body Weight: How and Why Do We Gain Weight Easier Than We Lose It?, 142Janine Makaronidis and Rachel L. Batterham Part 3 Pathogenesis of Diabetes 12 The Genetics of Diabetes, 157Rashmi B. Prasad 13 Genetics of Obesity, 197I. Sadaf Farooqi 14 Autoimmune Type 1 Diabetes, 203Omar Akel and Ake Lernmark 15 Other Disorders with Type 1 Diabetes and Atypical Phenotypes, 216Alice P.S. Kong, Elaine Y.K. Chow, Andrea O.Y. Luk, and Juliana C.N. Chan 16 Abnormalities of Insulin Secretion and β-Cell Defects in Type 2 Diabetes, 225Stefano Del Prato, Cristina Bianchi, and Giuseppe Daniele 17 Insulin Resistance in Type 2 Diabetes, 238Michael Roden, Kitt Falk Petersen, and Gerald I. Shulman 18 Obesity and Diabetes, 250Nick Finer 19 The Microbiome and Diabetes, 261Amanda J. Cox, Nicholas P. West, and Allan W. Cripps Part 4 Other Types of Diabetes 20 Monogenic Causes of Diabetes, 275Brittany L. Resnick, Maggie H. Shepherd, and Andrew T. Hattersley 21 Drug-Induced Diabetes, 295Charles D. Ponte and Devra K. Dang 22 Diabetes in Hypersecreting Endocrine Disorders, 304Allan A. Vaag, Neil A. Hanley, and Caroline M. Kistorp 23 Pancreatic Disease and Diabetes, 319Ranjit Unnikrishnan and Viswanathan Mohan 24 Clinical Presentations of Diabetes, 330Ee Lin Lim and Roy Taylor Part 5 Managing the Person with Diabetes 25 The Aims of Diabetes Care, 343Katharine D. Barnard-Kelly and Richard I.G. Holt 26 Education to Empower the Person with Diabetes, 354Ingrid Willaing and Michael Vallis 27 Dietary Management of Diabetes, 368Nicola Guess 28 Physical Activities and Diabetes, 382Emma J. Cockcroft and Robert C. Andrews 29 Monitoring Diabetes, 404Emma English 30 Biomarkers and Precision Medicine in Diabetes, 414Sok Cin Tye, Michele Provenzano, and Hiddo J.L. Heerspink Part 6 Treatment of Diabetes 31 Insulin and Insulin Treatment, 431Roman Vangoitsenhoven, Parth Narendran, and Chantal Mathieu 32 New Technologies for Glucose Monitoring, 444Thomas Danne and Olga Kordonouri 33 New Technologies for Insulin Administration, 459Hannah Forde and Pratik Choudhary 34 Whole Pancreas and Islet Cell Transplantation, 473Braulio A. Marfil-Garza, Peter A. Senior, and A.M. James Shapiro 35 Oral Glucose-Lowering Agents, 492Clifford J. Bailey and Andrew J. Krentz 36 Non-insulin Parenteral Therapies, 520Tina Vilsboll, Mikkel Christensen, Andreas Andersen, and Filip K. Knop 37 How to Use Type 2 Diabetes Treatments in Clinical Practice, 534Thomas Karagiannis, Aris Liakos, and Apostolos Tsapas 38 Weight Management and Metabolic Surgery, 551Alexis Sudlow, Dimitri J. Pournaras, and Carel W. le Roux 39 In-Hospital Treatment and Surgery in People with Diabetes, 559Ketan Dhatariya, Philip Newland-Jones, and Mayank Patel 40 Hypoglycaemia in Diabetes, 579Ahmed Iqbal, Elaine Y.K. Chow, Timothy W. Jones, and Simon R. Heller 41 Acute Metabolic Complications of Diabetes: Diabetic Ketoacidosis and the Hyperosmolar Hyperglycaemic State in Adults, 602Philip Newland-Jones, Mayank Patel, and Ketan Dhatariya Part 7 Microvascular Complications in Diabetes 42 Pathogenesis of Microvascular Complications, 615Allan Flyvbjerg 43 Diabetic Retinopathy, 629Toke Bek 44 Diabetic Nephropathy, 640Peter Rossing and Allan Flyvbjerg 45 Diabetic Neuropathy, 655Shazli Azmi, Uazman Alam, and Rayaz A. Malik Part 8 Macrovascular Complications in Diabetes 46 Pathogenesis of Macrovascular Complications in Diabetes, 681Jakob A. Ostergaard, Tomasz J. Block, Sophia Dahm, Waheed Khan, and Karin A.M. Jandeleit-Dahm 47 Hypertension and Diabetes, 700Peter M. Nilsson 48 Dyslipidaemia and Diabetes, 713Adie Viljoen, Ahmed Handhle, and Anthony S. Wierzbicki 49 Ischaemic Heart Disease in Diabetes, 724Michael Lehrke and Nikolaus Marx 50 Heart Failure and Diabetes, 732Ambarish Pandey, Kershaw V. Patel, and Subodh Verma 51 Cerebrovascular Disease and Diabetes, 745Colum F. Amory, Jesse Weinberger, and Travis S. Smith 52 Peripheral Vascular Disease, 755Henrik H. Sillesen Part 9 Other Complications of Diabetes 53 Foot Problems in People with Diabetes, 771Frank L. Bowling, Keeley J. Foley, and Andrew J.M. Boulton 54 Sexual Function in Men and Women with Diabetes, 780Kirsty Winkley, Camilla Kristensen, Jackie Fosbury, and David Price 55 Gastrointestinal Manifestations of Diabetes, 796Michael Camilleri and Adil E. Bharucha 56 Diabetes and Oral Health, 810Palle Holmstrup, Christian Damgaard, and Allan Flyvbjerg 57 Diabetes and Non-alcoholic Fatty Liver Disease, 820Alessandro Mantovani, Giovanni Targher, and Christopher D. Byrne 58 The Skin in Diabetes, 838Paul Devakar Yesudian 59 Bone and Rheumatic Disorders in Diabetes, 853Andrew Grey and Nicola Dalbeth 60 Diabetes and Cancer: Risk, Outcomes, and Clinical Implications, 867Ellena Badrick, Emily J. Gallagher, and Andrew G. Renehan 61 Diabetes and Infections, 878Andrea O.Y. Luk and Clive S. Cockram 62 Sleep and Diabetes, 897Sonya Deschênes, Amy McInerney, and Norbert Schmitz Part 10 Psychosocial Aspects of Diabetes 63 Psychosocial and Behavioural Aspects of Diabetes, 907Frans Pouwer and Jane Speight 64 Role of Cognitive Function in Managing People with Diabetes, 922Tamsin Santos, Chelsea Baird, Sally Eastwood, Kerrie Shiell, and Joseph E. Ibrahim 65 Mental Disorders and Diabetes, 933Najma Siddiqi, Marietta Stadler, and Richard I.G. Holt 66 Social Aspects of Diabetes, 956Brian M. Frier and Mark W.J. Strachan 67 Social Determinants of Diabetes, 973Keri F. Kirk, Gerald McKinley, Briana Mezuk, and Erica Spears Part 11 Diabetes in Special Groups 68 Ethnic, Cultural, and Religious Aspects to the Management of Diabetes, 987Wasim Hanif, Sarah N. Ali, and Vinod Patel 69 Diabetes in Childhood, 999Jennifer M. Ikle, Ananta Addala, and David M. Maahs 70 Adolescence and Emerging Adulthood: Diabetesin Transition, 1019Charlotte W. Chen and Lori M.B. Laffel 71 Diabetes in Pregnancy, 1034David R. McCance and Laura Cassidy 72 Diabetes in Old Age, 1072Ahmed H. Abdelhafiz and Alan J. Sinclair 73 Diabetes at the End of Life, 1085Trisha Dunning and June James Part 12 Delivery and Organization of Diabetes Care 74 The Role of the Multidisciplinary Team across Primary and Secondary Care, 1097Samuel Seidu and Kamlesh Khunti 75 Models of Diabetes Care in Low-and Middle-Income Countries, 1107David Beran, Sigiriya Aebischer Perone, and Maria Lazo-Porras Part 13 Future Directions 76 Immunotherapies for Type 1 Diabetes, 1125Jesper Johannesen and Flemming Pociot 77 Stem Cell Therapy in Diabetes, 1137Angelo Avogaro and Gian Paolo Fadini 78 Gene Therapy for Diabetes, 1144Veronica Jimenez and Fatima Bosch 79 Future Drug Treatments for Type 2 Diabetes, 1154Clifford J. Bailey Index, 1167
£193.46
Morgan James Publishing llc The Diabetes LIFEMAP: Data Driven Diabetes Care
Book SynopsisThe Diabetes LIFEMAP changes the way chronic diabetes care is delivered forever. The LIFEMAP raises diabetes care for the primary care and ancillary healthcare provider to the level of world renown diabetes expert, David Bleich, MD. For patients, the LIFEMAP provides real-time diabetes care that changes a “tough-to-manage” disease into a shared, personal, and efficient management experience. The LIFEMAP can be used as a stand-alone diabetes management tool or can be combined with our cloud based LIFEMAP platform through GoMo Health. Now care can be delivered seamlessly at home for both provider and patient. The Diabetes LIFEMAP is the playbook for 21st century diabetes care. It starts with an understanding of the basic principles of insulin secretion and moves to a discussion of how the LIFEMAP evolved and why it is such a powerful management tool. Finally, case studies are provided to reinforce basic concepts of LIFEMAP diabetes care with real world examples. Taken together, The Diabetes LIFEMAP succeeds in helping healthcare providers overcome a difficult to manage disease and provides patients with an optimal diabetes outcome with the least amount of effort necessary to achieve high level results.
£12.30
Penguin Young Readers Mastering Diabetes
Book SynopsisThe instant New York Times bestseller.A groundbreaking method to master all types of diabetes by reversing insulin resistance. Current medical wisdom advises that anyone suffering from diabetes or prediabetes should eat a low-carbohydrate, high-fat diet. But in this revolutionary book, Cyrus Khambatta, PhD, and Robby Barbaro, MPH, rely on a century of research to show that advice is misguided. While it may improve short-term blood glucose control, such a diet also increases the long-term risk for chronic diseases like cancer, high blood pressure, high cholesterol, chronic kidney disease, and fatty liver disease.The revolutionary solution is to eat a low-fat plant-based whole-food diet, the most powerful way to reverse insulin resistance in all types of diabetes: type 1, type 1.5, type 2, prediabetes, and gestational diabetes.As the creators of the extraordinary and effective Mastering Diabetes Method, Khambatta and Barbaro lay out a
£17.00
Georg Thieme Verlag Vademecum Metabolicum Diagnosis and Treatment of
Book Synopsis
£26.01
John Wiley & Sons Inc Iron Metabolism
Book SynopsisIron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health.The 4th edition of Iron Metabolism is written in a lively style by oTrade Review'This textbook is clearly a milestone which should be to hand for every researcher and scholar working on or interested in the biochemistry and clinical aspects of iron. Those needing to go further in depth on some specific aspects will find not only an excellent starting point but also their pathway through the impressive list of references at the end of each chapter.' Acta Cryst (International Union of Crystallography), November 2017Table of ContentsPreface xii 1 Solution Chemistry of Iron 1 1.1 Iron Chemistry 1 1.2 Interactions of Iron with Dioxygen and Chemistry of Oxygen Free Radicals 2 1.3 Hydrolysis of Iron Salts 5 1.4 Formation and Characterisation of Ferrihydrite 7 1.5 Ageing of Amorphous Ferrihydrite to more Crystalline Products 10 1.6 Biomineralisation 11 1.7 Magnetite Biomineralisation by Magnetotactic Bacteria 13 1.7.1 Biogenesis of the Magnetosome Membrane 15 1.7.2 Protein Sorting 15 1.7.3 Chain Formation 16 1.7.4 Biomineralisation 16 1.7.5 A Model for Magnetosome Formation 17 References 18 2 The Essential Role of Iron in Biology 22 2.1 Introduction: Iron an Essential Element in Biology 22 2.2 Physical Techniques for the Study of Iron in Biological Systems 25 2.3 Classes of Iron Proteins 29 2.4 Haemoproteins 29 2.4.1 Oxygen Carriers 30 2.4.2 Activators of Molecular Oxygen 34 2.4.3 Electron Transport Proteins 38 2.5 Iron–Sulphur Proteins 41 2.6 Non]haem, Non]Fe–S Proteins 48 2.6.1 Mononuclear Non]haem Iron Enzymes 48 2.6.1.1 Extradiol]cleaving Catechol Dioxygenases 49 2.6.1.2 Rieske Oxygenases 49 2.6.1.3 α]Ketoglutarate]dependent Enzymes 52 2.6.1.4 Pterin]dependent Hydroxylases 54 2.6.1.5 Miscellaneous Enzymes 55 2.6.2 Dinuclear Non]haem Iron Proteins 55 2.6.3 Proteins of Iron Storage, Transport and Metabolism 61 2.7 The Dark Side of Iron: Ros , Rns and Ntbi 62 2.7.1 ROS and RNS 63 2.7.2 NTBI and LPI 64 References 64 3 Microbial Iron Uptake 71 3.1 Introduction 71 3.2 Iron Uptake from Siderophores 74 3.2.1 Siderophores 74 3.2.2 Iron Transport across the Outer Membrane in Gram]negative Bacteria 78 3.2.3 Transport across the Periplasm and Cytoplasmic Membrane in Gram]negative Bacteria 86 3.2.4 Iron Uptake by Gram]positive Bacteria 92 3.3 Fe2+ Transport Systems 93 3.4 Iron Release from Siderophores in the Cytoplasm 97 3.5 Intracellular Iron Metabolism 98 3.6 Control of Gene Expression by Iron 101 References 108 4 Iron Acquisition by Pathogens 120 4.1 Introduction 120 4.2 Host Defence Mechanisms, Nutritional Immunity 121 4.3 Pathogenicity and PAIs 123 4.4 Pathogen]specific Iron Uptake Systems 125 4.4.1 Siderophores Associated with Virulence 125 4.4.2 Transferrin/lactoferrin Iron Uptake 126 4.4.3 Haem Iron Uptake 133 4.4.4 Ferrous Iron Uptake 138 4.4.5 Ferric Citrate Uptake by Bacillus cereus 141 4.5 Role of Fur and Fur Homologues in Virulence 141 4.6 Role of Pathogen Ecf Sigma Factors 141 4.7 Fungal Pathogens 143 References 146 5 Iron Uptake by Plants and Fungi 155 5.1 Iron Uptake by Plants 155 5.1.1 Introduction 155 5.1.2 Genome Sequencing 157 5.1.2.1 Quantitative Trait Loci 158 5.1.3 Iron Acquisition by the Roots of Plants 160 5.1.3.1 Non]graminaceous Plants 161 5.1.3.2 Graminaceous Plants 164 5.1.4 Long]distance Iron Transport 166 5.2 Iron Metabolism and Homeostasis in Plants 169 5.2.1 New Tools in Plant Research 169 5.2.2 Intracellular Iron Metabolism 170 5.2.3 Plant Iron Homeostasis 171 5.2.4 Diurnal Regulation of Iron Homeostasis 176 5.3 Iron Uptake, Metabolism and Homeostasis in Fungi 178 5.3.1 Introduction 178 5.3.2 High] and Low]affinity Iron Uptake Pathways 179 5.3.3 Siderophore]mediated Iron Uptake 184 5.3.4 Intracellular Iron Metabolism 185 5.3.5 Iron Homeostasis 186 References 190 6 Cellular Iron Uptake and Export in Mammals 205 6.1 The Transferrins 205 6.1.1 Introduction 205 6.1.2 The Transferrin Family 206 6.1.3 Structure of Transferrins 211 6.1.4 Transferrin iron Binding 215 6.1.5 Binding of other Metals by Transferrin 218 6.2 Cellular Iron Uptake 219 6.2.1 The Transferrin Receptors 219 6.2.2 The Transferrin to Cell Cycle and Iron Release 222 6.2.3 Iron Uptake from other Sources 228 6.3 Cellular Iron Export 230 References 236 7 Mammalian Iron Metabolism and Dietary Iron Absorption 247 7.1 An overview of Mammalian Iron Metabolism 247 7.1.1 Introduction 247 7.1.2 The Way Different Cells Handle Iron 249 7.2 Mammalian Iron Absorption 251 7.2.1 Introduction 251 7.2.2 The Intestinal Mucosa 252 7.2.3 Sources of Dietary Iron 253 7.2.4 Iron Loss and Effects on Uptake 255 7.3 Molecular Mechanisms of Mucosal Iron Absorption 256 7.3.1 Iron Uptake at the Apical Pole 256 7.3.2 Iron Transit through and Storage in Enterocytes 259 7.3.3 Iron Efflux across the Basolateral Membrane 259 7.3.4 Regulation of Iron Uptake by the Enterocyte 261 References 261 8 Intracellular Iron Utilisation 265 8.1 Intracellular Iron Pools 265 8.1.1 Introduction 265 8.1.2 The Cytosolic Labile Iron Pool (LIP) 266 8.1.3 Distribution of Iron in the Cytosol 268 8.1.4 Other Intracellular Iron Pools 269 8.2 Mitochondrial Iron Metabolism 271 8.2.1 Mitochondrial Iron Uptake and Storage 271 8.2.2 Mitochondrial Fe–S Protein Biogenesis 271 8.2.3 Maturation of Cytosolic and Nuclear Fe–S Proteins 275 8.2.4 Haem Biosynthesis 283 8.3 Haem Oxygenase 287 8.3.1 Structure and Catalytic Cycle 287 8.3.2 Activation of Haem Oxygenase 1 (HO]1) 292 References 292 9 Iron Storage Proteins 300 9.1 Introduction 300 9.2 The Ferritin Superfamily and Haemosiderins 301 9.2.1 The Ferritin Superfamily 301 9.2.2 Structure of Vertebrate and Invertebrate Ferritins 304 9.2.3 Plant and Bacterial Ferritins 308 9.2.4 Dps Proteins and Rubrerythrins 313 9.2.5 The Mineral Core 319 9.2.6 Haemosiderins 319 9.3 Iron Uptake and Release from Ferritin 320 9.3.1 Iron Uptake in Ferritins 320 9.3.1.1 Entry of Fe(II) into the Protein Shell 321 9.3.1.2 Oxidation of Fe2+ by Ferroxidase Sites 323 9.3.1.3 Mineralisation of the Iron Core 325 9.3.2 Iron Uptake in Dps Proteins 333 9.3.3 Iron Release from Ferritin 333 9.4 Biotechnological Applications of Ferritins 335 References 336 10 Cellular and Systemic Iron Homeostasis 346 10.1 Cellular Iron Homeostasis 346 10.1.1 Translational Control of Protein Synthesis 346 10.1.2 The IRE/IRP System 347 10.1.3 The IREs – distribution and Structure 348 10.1.4 Structural Features of IRP1 and 2 351 10.1.5 The IRE/IRP System Revisited – Iron Controls Iron 353 10.1.6 Metabolic Consequences of Mutations in Ires 357 10.2 Systemic Iron Homeostasis 357 10.2.1 Introduction 357 10.2.2 Hepcidin, the Key Player 358 10.2.3 Factors which Regulate Hepcidin Synthesis 360 10.2.3.1 Iron Availability 361 10.2.3.2 Inflammatory Stimuli 364 10.2.3.3 Erythropoietic Demand 364 10.2.3.4 Hypoxia 365 10.2.3.5 Endocrine Signals 366 10.3 Integration of Iron Homeostatic Systems 367 References 367 11 Iron Deficiency, Iron Overload and Therapy 376 11.1 Iron]deficiency Anaemia (Ida) 376 11.1.1 Introduction – The Size of the Problem 376 11.1.2 Causes of Ida 378 11.1.3 Clinical Stages and Diagnosis of Ida 380 11.1.4 Therapeutic Approaches 383 11.1.5 Anaemia of Chronic Disease (Acd ), Iron Refractory Ida (Irida ) and Anaemia of Chronic Kidney Disease (Ckd) 384 11.2 Hereditary Iron Overload 386 11.2.1 Introduction 386 11.2.2 Hereditary Haemochromatosis (Hh) 386 11.2.3 Causes of HH 387 11.2.4 Types of Haemochromatosis 388 11.2.4.1 Hfe]related (Type 1) Haemochromatosis 388 11.2.4.2 Juvenile (Type 2) Haemochromatosis 390 11.2.4.3 Tfr2]related (Type 3) Haemochromatosis 390 11.2.4.4 Ferroportin Disease 390 11.2.5 Therapy of Hereditary Haemochromatosis 391 11.3 Acquired Iron Overload 395 11.3.1 Introduction – Causes of Acquired Iron Overload 395 11.3.2 Mechanisms of Iron Toxicity 397 11.3.3 Evaluation of Iron Overload 398 11.3.4 Chelation Therapy for Acquired Iron Overload 400 11.3.5 Other Therapeutic Approaches 405 References 406 12 Iron and Immunity 418 12.1 Introduction 418 12.1.1 Innate Immunity 419 12.2 The Key Role of Macrophages 422 12.2.1 Overview 422 12.2.2 Macrophage Phenotypes 425 12.2.3 Microglia 426 12.3 Effect of Iron Status on Phagocytic Cell Function 429 12.3.1 Iron Deficiency 429 12.3.2 Iron Overload 430 12.4 Effect of Phagocytic Cell Function on Iron Metabolism 431 12.4.1 The IRE–Iron Regulatory Protein (IRP) System 431 12.5 Effector Molecules of the Innate Immune System 433 12.5.1 Toll]like Receptors 433 12.5.2 NF]κB 433 12.5.3 Hypoxia]Inducible Factor 1 (Hif 1) 434 12.5.4 Haem Oxygenase 435 12.5.5 DMT1, Nramp1 437 12.6 Adaptive Immunity 437 12.6.1 Cd8+ Lymphocytes and Cytotoxicity 438 12.6.2 CD4+ lymphocytes 438 12.7 Immune Function and other Factors 438 12.7.1 Iron Supplementation and Immune Function 438 12.7.2 Immune Function in the Elderly Population 439 12.7.3 Iron Overload and Immune Function 439 12.7.4 Thalassaemia 440 12.8 Concluding Remarks 440 References 440 13 Iron and Oxidative Stress 444 13.1 Oxidative stress 444 13.1.1 Introduction – Milestones in the History of Life 444 13.1.2 Reactive Oxygen Species (Ros ) and Reactive Nitrogen Species (Rns) 447 13.1.3 Cellular Defence Mechanisms Against Oxidative Stress 450 13.1.4 Role of ROS and RNS in Cell Signalling 460 13.1.5 ROS, RNS and Oxidative Damage 466 References 476 14 Interactions between Iron and other Metals 482 14.1 Introduction 482 14.2 Iron Interactions with Essential Metals 483 14.2.1 Copper 483 14.2.1.1 Introduction 483 14.2.1.2 Copper Acquisition and Metabolism 485 14.2.1.3 Copper Chaperones 486 14.2.1.4 Iron–copper Interactions 487 14.2.2 Zinc 494 14.2.2.1 Introduction 494 14.2.2.2 Iron–zinc Interactions 496 14.2.3 Cobalt 497 14.2.3.1 Introduction 497 14.2.3.2 Iron–cobalt Interactions 498 14.2.4 Manganese 500 14.2.4.1 Iron–manganese Interactions 500 14.2.5 Calcium 501 14.2.5.1 Iron–calcium Interactions 501 14.3 Iron Interactions with Toxic Metals 502 14.3.1 Lead 502 14.3.2 Cadmium 503 14.3.3 Aluminium 505 References 507 15 Iron Homeostasis and Neurodegeneration 516 15.1 Introduction 516 15.2 Brain iron 517 15.2.1 Brain Iron Homeostasis 517 15.2.2 Aging and Brain Iron Content 518 15.3 Iron and Neurodegeneration 522 15.3.1 Introduction 522 15.3.2 Adverse Effects of Iron in Neurodegeneration 522 15.3.2.1 Toxicity of ROS and RNS 522 15.3.2.2 Iron and Mitochondrial Function 523 15.3.2.3 Protein Aggregation 523 15.4 Neurodegeneration with Brain Iron Accumulation 524 15.4.1 Aceruloplasminaemia 524 15.4.2 Neuroferritinopathy 526 15.4.3 Other NBIAs 528 15.5 Other Monogenic Neurodegenerative Diseases 530 15.5.1 Huntington’s Disease 530 15.5.2 Friedreich’s Ataxia 532 15.6 Neurodegeneration Involving Multiple Genes 533 15.6.1 Parkinson’s Disease (PD) 533 15.6.2 Alzheimer’s Disease (AD) 535 15.6.3 Multiple Sclerosis (MS) 537 15.7 Intracerebral Haemorrhage 538 References 539 Concluding Remarks 544 Index 547
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Nova Science Publishers Inc Neurochemistry of Metabolic Diseases: Lysosomal
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Book SynopsisThe literature concerning muscle Glycogenoses reflects a world-wide interest which has been greatly intensified, mainly over the last ten years. To a large extent, this renewed interest is due to recent advances in diagnosing and treating the Lysosomal disease named Glycogenosis II or Pompe disease (GSD II). The new therapeutic approaches must induce us to make a great effort in order to better diagnose, treat and follow correctly the patients with Pompe disease. This book is a comprehensive text which covers all of the aspects regarding this disease, from pathogenic to clinical and therapeutic features.
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Book SynopsisThe literature concerning muscle Glycogenoses reflects a world-wide interest which has been greatly intensified, mainly over the last ten years. To a large extent, this renewed interest is due to recent advances in diagnosing and treating the Lysosomal disease named Glycogenosis II or Pompe disease (GSD II). The new therapeutic approaches must induce us to make a great effort in order to better diagnose, treat and follow correctly the patients with Pompe disease. This book is a comprehensive text which covers all of the aspects regarding this disease, from pathogenic to clinical and therapeutic features.
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Oxford University Press, USA Hans Krebs Volume 2 Architect of Intermediary Metabolism 19331937 Monographs on the History and Philosophy of Biology
Book SynopsisThis second and final volume of the biography of Hans Krebs covers his early years in England, 1933-1937, when he laid the foundations of our modern understanding of intermediary metabolism.Trade Review'This is not only a study of Krebs's research, it is also a comprehensive biography of Krebs's personal as well as scientific life ... These two volumes represent an extraordinary achievement, as a biography of a man, living in a time of turmoil and upheaval, who emerged as a great scientists. The story of both the man and the science is full and rewarding. Among studies of biochemists, I know of nothing in the least comparable with Holmes's achievement here, in its depth and breadth.' John T. Edsall, Harvard University, Nature, Vol. 366, December 1993'This is the second and concluding volume of Holmes' biography of Hans Krebs ... a remarkable ad detailed account of a significant period in the development of biochemistry, reflected in the work of a major "architect."' Nathaniel I. Berlin, University of Miami, JAMA, Vol. 271, No. 14, 1994'Tis is a substantial scientific biography covering four years of the life of Krebs ... There is an enormous amount of detail and the book will be of interest mainly to scientific historians.' Aslib Book Guide, Vol. 59, No. 6, June 1994Table of ContentsIntroduction ; 1. A new home for a career ; 2. Laboratory life in Cambridge ; 3. Progress under pressure ; 4. New moves ; 5. Arrivals and partings ; 6. The "Great Work" ; 7. Relocations and dismutations ; 8. Main routes and carriers ; 9. Full circle ; 10. Reflections ; Guide to structural formulas ; Notes
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Taylor & Francis Ltd Muscle Metabolism 4 Frontiers in Animal Diabetes
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